keyword
MENU ▼
Read by QxMD icon Read
search

Sex differences, animals, depression

keyword
https://www.readbyqxmd.com/read/29858858/sex-differences-in-stress-responses-a-critical-role-for-corticotropin-releasing-factor
#1
REVIEW
Debra A Bangasser, Kimberly R Wiersielis
Rates of post-traumatic stress disorder, panic disorder, and major depression are higher in women than in men. Another shared feature of these disorders is that dysregulation of the stress neuropeptide, corticotropin-releasing factor (CRF), is thought to contribute to their pathophysiology. Therefore, sex differences in responses to CRF could contribute to this sex bias in disease prevalence. Here, we review emerging data from non-human animal models that reveal extensive sex differences in CRF functions ranging from its presynaptic regulation to its postsynaptic efficacy...
March 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29803894/impact-of-selective-serotonin-reuptake-inhibitors-ssris-during-pregnancy-and-lactation-a-focus-on-short-and-long-term-vascular-effects
#2
REVIEW
S Zullino, T Simoncini
SSRIs are the first choice for the treatment of mood disorders during pregnancy and lactation. Despite the known side effects, the benefits/risks balance suggests their use. Hypertensive disorders of pregnancy (HDP) and Intrauterine growth restriction (IUGR) are the main vascular effects of these drugs, with mechanisms that involves endothelial dysfunction in feto-placental system. These data are supported by animal models, even if preliminary findings are not yet adequately supported by molecular and clinical data...
May 24, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29800644/sex-specific-effects-of-cacna1c-haploinsufficiency-on-object-recognition-spatial-memory-and-reversal-learning-capabilities-in-rats
#3
Moria D Braun, Theresa M Kisko, Débora Dalla Vecchia, Roberto Andreatini, Rainer K W Schwarting, Markus Wöhr
The CACNA1C gene is strongly implicated in the etiology of multiple major neuropsychiatric disorders, such as bipolar disorder, major depression, and schizophrenia, with cognitive deficits being a common feature. It is unclear, however, by which mechanisms CACNA1C variants advance the risk of developing neuropsychiatric disorders. This study set out to investigate cognitive functioning in a newly developed genetic Cacna1c rat model. Specifically, spatial and reversal learning, as well as object recognition memory were assessed in heterozygous Cacna1c+/- rats and compared to wildtype Cacna1c+/+ littermate controls in both sexes...
May 22, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29791834/molecular-and-functional-sex-differences-of-noradrenergic-neurons-in-the-mouse-locus-coeruleus
#4
Bernard Mulvey, Dionnet L Bhatti, Sandeep Gyawali, Allison M Lake, Skirmantas Kriaucionis, Christopher P Ford, Michael R Bruchas, Nathaniel Heintz, Joseph D Dougherty
Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders. Such disorders are often treated by drugs targeting the CNS norepinephrine system. Despite roles for noradrenergic neurons in behavior and neuropsychiatric disease models, their molecular characterization has lagged. We profiled mouse noradrenergic neurons in vivo, defining over 3,000 high-confidence transcripts expressed therein, including druggable receptors...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29764242/morbidity-and-mortality-resulting-from-acute-inhalation-exposures-to-hydrogen-fluoride-and-carbonyl-fluoride-in-rats
#5
Adolph J Januszkiewicz, Matthew A Bazar, Lee C B Crouse, Michael A Chapman, Steven E Hodges, Steven J McCormick, Arthur J O'Neill
OBJECTIVE: Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF2 ). METHODS: Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF2 . Respiration was monitored before, during, and after exposure. Animals were observed up to 6 days post-exposure. Terminal blood samples were collected for routine clinical chemistry and hematology...
May 15, 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29685134/oral-sensitization-to-whey-proteins-induces-age-and-sex-dependent-behavioral-abnormality-and-neuroinflammatory-responses-in-a-mouse-model-of-food-allergy-a-potential-role-of-mast-cells
#6
Danielle L Germundson, Nicholas A Smith, Lane P Vendsel, Andrea V Kelsch, Colin K Combs, Kumi Nagamoto-Combs
BACKGROUND: Growing evidence has strengthened the association of food allergy with neuropsychiatric symptoms such as depression, anxiety, and autism. However, underlying mechanisms by which peripheral allergic responses lead to behavioral dysfunction are yet to be determined. Allergen-activated mast cells may serve as mediators by releasing histamine and other inflammatory factors that could adversely affect brain function. We hypothesized that eliciting food allergy in experimental animals would result in behavioral changes accompanied by mast cell accumulation in the brain...
April 23, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29678754/sex-and-age-dependent-effects-of-orexin-1-receptor-blockade-on-open-field-behavior-and-neuronal-activity
#7
Shannon R Blume, Hannah Nam, Sandra Luz, Debra A Bangasser, Seema Bhatnagar
Adolescence is a sensitive and critical period in brain development where psychiatric disorders such as anxiety, depression and post-traumatic stress disorder are more likely to emerge following a stressful life event. Females are two times more likely to suffer from psychiatric disorders than males. Patients with these disorders show alterations in orexins (also called hypocretins), important neuropeptides that regulate arousal, wakefulness and the hypothalamic-pituitary-adrenal axis activity. Little is known on the role of orexins in mediating arousal behaviors in male and female rats during adolescence or adulthood...
June 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29544105/pharmacokinetic-differences-of-mifepristone-between-sexes-in-animals
#8
Wenge Chen, Yunlong Cheng, Jianzhong Chen, Jiahang Chen, Kai Jiang, Yuyang Zhou, Lee Jia
Mifepristone (RU486) is developed originally as a contraceptive used by hundreds of millions of women world-wide, and also reported as a safe and long-term psychotic depressant, or as a cancer chemotherapeutic agent used by both sexes. In our preliminary study aimed at developing mifepristone as a cancer metastatic chemopreventive, we coincidentally observed that blood mifepristone concentrations in female rats seem to be higher than those in male ones post administration. To substantiate if the pharmacokinetic differences between sexes exist, we established a fast UPLC-MS/MS method to determine mifepristone concentrations in plasma, and analyzed blood concentrations of mifepristone over time in rats and dogs of both sexes...
May 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29476894/sex-differences-in-the-neuroadaptations-of-reward-related-circuits-in-response-to-subchronic-variable-stress
#9
Song Zhang, Hongxing Zhang, Stacy M Ku, Barbara Juarez, Carole Morel, Nikos Tzavaras, Sarah Montgomery, Georgia E Hodes, Anna Brancato, Scott J Russo, Jun-Li Cao, Ming-Hu Han
Women are twice as likely to be diagnosed with major depressive disorder. However, fewer studies in rodent models of depression have used female animals, leading to a relative lack of understanding of the female brain's response to stress, especially at a neural circuit level. In this study, we utilized a 6-day subchronic variable stress (SCVS) mouse model and measured novelty suppressed feeding as behavioral criteria to evaluate susceptibility to SCVS in male and female mice. First, we showed that SCVS induced a decrease in latency to eat (susceptible phenotype) in female mice, but not in males (resilient phenotype)...
April 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29430564/sensory-symptom-profiles-differ-between-trigeminal-and-thoracolumbar-postherpetic-neuralgia
#10
Stefanie Rehm, Moritz Groβkopf, Maria Kabelitz, Thomas Keller, Rainer Freynhagen, Thomas R Tölle, Ralf Baron
Introduction: Animal experimental evidence suggests that mechanisms of pain generation and response to treatment differ between neuropathic pain in the cephalic and the extracephalic innervation territories. Objectives: The objective of the study was to examine whether in humans an identical peripheral painful neuropathy is associated with different pain qualities and sensory abnormalities in the face as compared with the thoracic region. Methods: We retrospectively analysed epidemiological and clinical data of 639 patients with postherpetic neuralgia (PHN) in the face and at the trunk who were collected within a cross-sectional cohort survey and compared the respective sensory symptom profiles captured with the painDETECT questionnaire...
January 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29241126/the-chronic-exposure-to-abamectin-causes-spatial-memory-deficit-and-depressive-behavior-in-mice
#11
Wellington Alves Mizael da Silva, Abraão Tiago Batista Guimarães, Mateus Flores Montalvão, Bruna de Oliveira Mendes, Aline Sueli de Lima Rodrigues, Guilherme Malafaia
It is known that abamectin (ABA), which is a component belonging to the group of avermectins, has been broadly used as biopesticide. Although its effect on non-target aquatic organisms is known, knowledge about its impacts on terrestrial animals such as mammals remains incipient. Thus, we aim at investigating the effects (phycical and neural-behavioral) from the chronic exposure (90 days) to ABA (1/10 of LD50 ) on Swiss and C57Bl/6J mice from both sexes. Accordingly, at the end of the experimental period the animals were subjected to the following tests: Novel Object Recognition Test (NORT), Morris Water Maze (MWM), Tail Suspension Test (TST), and Forced Swimming Test (FST)...
March 2018: Chemosphere
https://www.readbyqxmd.com/read/29187314/what-is-stressful-for-females-differential-effects-of-unpredictable-environmental-or-social-stress-in-cd1-female-mice
#12
Harold Dadomo, Laura Gioiosa, Jenny Cigalotti, Graziano Ceresini, Stefano Parmigiani, Paola Palanza
Stressful life events are a major factor in the etiology of several diseases, such as cardiovascular, inflammatory and psychiatric disorders (i.e., depression and anxiety), with the two sexes greatly differing in vulnerability. In humans and other animals, physiological and behavioral responses to stress are strongly dependent on gender, and conditions that are stressful for males are not necessarily stressful for females. Hence the need of an animal model of social chronic stress specifically designed for females...
February 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29128294/behavioral-depression-is-associated-with-increased-vagally-mediated-heart-rate-variability-in-adult-female-cynomolgus-monkeys-macaca-fascicularis
#13
Marc N Jarczok, Julian Koenig, Carol A Shively, Julian F Thayer
INTRODUCTION: Depressive symptoms (DS) in humans are associated with decreased resting state vagal activity, but sex seems to moderate this association. Recently, in human females DS have been associated with greater or similar cardiac vagal activity compared to men in both, clinical and non-clinical samples. A previously validated animal model of behavioral depression was used in the present study to investigate the association of DS and cardiac vagal activity in non-human primates. METHODS: The root mean square of successive differences between adjacent heart beats (RMSSD) was used as an indicator of vagally-mediated heart rate variability in 24h heart rate recordings collected via telemetry in 42 adult female cynomolgus monkeys (Macaca fascicularis)...
November 8, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29077998/a-pilot-study-of-reduced-olfactory-bulb-volume-as-a-marker-of-ptsd-in-childhood-trauma-exposed-adult-hiv-infected-patients
#14
Evaristus A Nwulia, Narayan Rai, Kamyar Sartip, Maria Mananita S Hipolito, Charlee K McLean, Kyla Flanagan, Flora Hamilton, Sharon Lambert, Huynh-Nhu Le, John VanMeter, Suad Kapetanovic
Evidence suggests that olfactory bulb (OB), a key structure in odor processing, may also be involved in mechanisms of traumatic stress. In animals, chronic stress reduces OB plasticity, and olfactory bulbectomy results in stress-enhanced startle reflex and autonomic dysregulation. However, OB morphometry has not been adequately studied in the development of stress disorders following childhood trauma in humans. The researchers conducted a pilot study evaluating the relationships between OB volume, childhood trauma, and lifetime posttraumatic stress disorder (PTSD) in a sample of 16 HIV-positive individuals, 13 of whom were exposed to childhood trauma of 9 developed PTSD...
October 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29030008/assessment-of-leukocyte-activity-in-mice-devoid-of-the-glucocorticoid-receptor-in-the-noradrenergic-system-gr-dbhcre
#15
Adam Roman, Justyna Kuśmierczyk, Grzegorz Kreiner, Irena Nalepa
Disturbances in brain monoamines, overactivity of the hypothalamo-pituitary adrenal (HPA) axis and pro-inflammatory tendency in the immune system are the key features of depressive disorders. Recently, several murine lines with mutations in glucocorticoid receptors (GRs) have been generated and these animals may be utilized for study depressive-like disorders. In the present study, we have investigated whether selective ablation of GRs in noradrenergic neurons affects functional properties of leukocytes and redirects them towards pro-inflammatory activity...
October 8, 2017: Immunobiology
https://www.readbyqxmd.com/read/28992584/ogt-related-mitochondrial-motility-is-associated-with-sex-differences-and-exercise-effects-in-depression-induced-by-prenatal-exposure-to-glucocorticoids
#16
Weina Liu, Hongmei Wang, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi, Liu Ji
BACKGROUND: Prenatal exposure to glucocorticoids (GCs) has been found to trigger abnormal behaviors and deleterious neurological effects on offspring both in animals and in humans. The sex differences in depression have been replicated in numerous studies across cultures, persisting throughout the reproductive years. As an X-linked gene in rodents and in humans, O-GlcNAc transferase (OGT) may provide a novel perspective for the sex differences in depression. METHODS: In the last third of pregnancy (gestational day 14-21), rats were subcutaneously administered either 0...
September 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28970177/long-lasting-effects-of-early-life-intervention-in-mice-on-adulthood-behaviour-gaba-a-receptor-subunit-expression-and-synaptic-clustering
#17
Kelly J Skilbeck, Graham A R Johnston, Tina Hinton
Variations in the early postnatal environment of rodents produce long-term changes in responses to stress that may underlie neuropsychiatric diseases such as anxiety, depression and schizophrenia. GABAA receptors undergo marked changes in their subunit composition during this period, involving a regionally-dependent replacement of α2 with α1 subunits, the so-called α-subunit switch. In this study we examined the effects of early-life environment on adulthood GABAA receptor α1 and α2 subunit expression and the synaptic clustering of GABAA receptors...
February 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28760765/high-sex-ratios-in-rural-china-declining-well-being-with-age-in-never-married-men
#18
Xudong Zhou, Therese Hesketh
In parts of rural China male-biased sex ratios at birth, combined with out-migration of women, have led to highly male-biased adult sex ratios, resulting in large numbers of men being unable to marry, in a culture where marriage and reproduction are an expectation. The aim of this study was to test the hypotheses that older unmarried men are more predisposed to depression, low self-esteem and aggression than both those who are married, and those who are younger and unmarried. Self-completion questionnaires were administered among men aged 20-40 in 48 villages in rural Guizhou province, southwestern China...
September 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28755980/profiling-coping-strategies-in-male-and-female-rats-potential-neurobehavioral-markers-of-increased-resilience-to-depressive-symptoms
#19
Molly Kent, Massimo Bardi, Ashley Hazelgrove, Kaitlyn Sewell, Emily Kirk, Brooke Thompson, Kristen Trexler, Brennan Terhune-Cotter, Kelly Lambert
Coping strategies have been associated with differential stress responsivity, perhaps providing a valuable neurobiological marker for susceptibility to the emergence of depressogenic symptoms or vulnerability to other anxiety-related disorders. Rats profiled with a flexible coping phenotype, for example, exhibit increased neurobiological markers of emotional regulation compared to active and passive copers (Bardi et al., 2012; Lambert et al., 2014). In the current study, responses of male and female rats to prediction errors in a spatial foraging task (dry land maze; DLM) were examined after animals were exposed to chronic unpredictable stress (CUS)...
September 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28698378/haploid-selection-within-a-single-ejaculate-increases-offspring-fitness
#20
Ghazal Alavioon, Cosima Hotzy, Khriezhanuo Nakhro, Sandra Rudolf, Douglas G Scofield, Susanne Zajitschek, Alexei A Maklakov, Simone Immler
An inescapable consequence of sex in eukaryotes is the evolution of a biphasic life cycle with alternating diploid and haploid phases. The occurrence of selection during the haploid phase can have far-reaching consequences for fundamental evolutionary processes including the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutations, as well as for applied research into fertilization technology. Although haploid selection is well established in plants, current dogma assumes that in animals, intact fertile sperm within a single ejaculate are equivalent at siring viable offspring...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
86423
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"