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Sex differences, animals, depression

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https://www.readbyqxmd.com/read/28698378/haploid-selection-within-a-single-ejaculate-increases-offspring-fitness
#1
Ghazal Alavioon, Cosima Hotzy, Khriezhanuo Nakhro, Sandra Rudolf, Douglas G Scofield, Susanne Zajitschek, Alexei A Maklakov, Simone Immler
An inescapable consequence of sex in eukaryotes is the evolution of a biphasic life cycle with alternating diploid and haploid phases. The occurrence of selection during the haploid phase can have far-reaching consequences for fundamental evolutionary processes including the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutations, as well as for applied research into fertilization technology. Although haploid selection is well established in plants, current dogma assumes that in animals, intact fertile sperm within a single ejaculate are equivalent at siring viable offspring...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28695280/effect-of-post-weaning-isolation-on-anxiety-and-depressive-like-behaviors-of-c57bl-6j-mice
#2
Qian Huang, Ying Zhou, Lin-Yun Liu
Effects of post-weaning isolation on depressive- and anxiety-like behaviors in rodents have been well studied in the past. However, few studies included both sexes in a single experiment to study the sex difference in this animal model. The present study investigated the effect of post-weaning isolation on anxiety- and depressive-like behaviors in both male and female C57BL/6 J mice. Mice were individually or grouped housed from postnatal day 21 for 5 weeks until behavioral tests began. The results showed that social isolation resulted in increased anxiety in the open field...
July 10, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28527954/sex-differences-in-the-effect-of-chronic-mild-stress-on-mouse-prefrontal-cortical-bdnf-levels-a-role-of-major-ovarian-hormones
#3
Bhanu Chandra Karisetty, Pranav Chintamani Joshi, Arvind Kumar, Sumana Chakravarty
Depression induced by stress is affected by sex, age and hormonal status of the animal and also by duration and type of the stressors. Moreover, higher prevalence of depression and comorbidities in women than men implies the need to include the sex variable in studies on animal models of depression. The present study was therefore initiated to evaluate the effect of sex and ovarian hormones on depression-like phenotypes in mice exposed to a 21-day Chronic Variable Mild Stress (CVMS) paradigm. Adult male, intact female and, ovariectomized (OVX) female mice exposed to CVMS displayed despair behavior, a depression-like phenotype, in all the groups...
May 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28462362/early-life-stress-leads-to-developmental-and-sex-selective-effects-on-performance-in-a-novel-object-placement-task
#4
Kevin G Bath, Arielle Schilit Nitenson, Ezra Lichtman, Chelsea Lopez, Whitney Chen, Meghan Gallo, Haley Goodwill, Gabriela Manzano-Nieves
Disruptions in early life care, including neglect, extreme poverty, and trauma, influence neural development and increase the risk for and severity of pathology. Significant sex disparities have been identified for affective pathology, with females having an increased risk of developing anxiety and depressive disorder. However, the effects of early life stress (ELS) on cognitive development have not been as well characterized, especially in reference to sex specific impacts of ELS on cognitive abilities over development...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28324704/bxd-recombinant-inbred-strains-participate-in-social-preference-anxiety-and-depression-behaviors-along-sex-differences-in-cytokines-and-tactile-allodynia
#5
Caridad López-Granero, Alessandra Antunes Dos Santos, Beatriz Ferrer, Megan Culbreth, Sudipta Chakraborty, Angel Barrasa, Maria Gulinello, Aaron B Bowman, Michael Aschner
Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers...
June 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28323008/sub-chronic-variable-stress-induces-sex-specific-effects-on-glutamatergic-synapses-in-the-nucleus-accumbens
#6
Anna Brancato, Dana Bregman, H Francisica Ahn, Madeline L Pfau, Caroline Menard, Carla Cannizzaro, Scott J Russo, Georgia E Hodes
Men and women manifest different symptoms of depression and under current diagnostic criteria, depression is twice as prevalent in woman. However, little is known of the mechanisms contributing to these important sex differences. Sub-chronic variable stress (SCVS), a rodent model of depression, induces depression-like behaviors in female mice only, modeling clinical evidence of higher susceptibility to mood disorders in women. Accumulating evidence indicates that altered neuroplasticity of excitatory synapses in the nucleus accumbens (NAc) is a key pathophysiological feature of susceptibility to social stress in males...
May 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28302071/sex-differences-in-the-molecular-signature-of-the-developing-mouse-hippocampus
#7
Joseph L Bundy, Cynthia Vied, Richard S Nowakowski
BACKGROUND: A variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, major depressive disorder, dyslexia and autism, are differentially prevalent between females and males. To better understand the possible molecular basis for the sex-biased nature of neurological disorders, we used a developmental series of female and male mice at 1, 2, and 4 months of age to assess both mRNA and protein in the hippocampus with RNA-sequencing and mass-spectrometry, respectively...
March 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28205080/assessment-of-cu-zn-edta-parenteral-toxicity-in-calves
#8
Luis Emilio Fazzio, Diana Esther Rosa, Sebastian Julio Picco, Guillermo Alberto Mattioli
Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Zn EDTA appears as an alternative; however, data about its toxicity is unknown. The aim of this study was to assess toxicity risk of different doses of Cu-Zn EDTA in calves. Thirty two Aberdeen Angus calves of 162 (±20) kg BW were assigned to 4 groups (n = 8), homogeneous in weight, sex, and age...
February 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28088551/individual-and-sex-differences-in-high-and-low-responder-phenotypes
#9
María B Carreira, Ricardo Cossio, Gabrielle B Britton
Individual differences in responses to a novel environment are an important tool to predict predisposition to neuropsychiatric disorders. One way to examine individual differences involves classifying animals based on locomotion in a novel context. In this study we focused on individual and sex differences by categorizing female and male mice as high (HR) or low responders (LR) on the basis of open field locomotion. We then assessed whether groups differed on behavioral measures of spontaneous alternations, anxiety, depression and contextual fear conditioning...
March 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28017851/immediate-and-delayed-anxiety-and-depression-like-profiles-in-the-adolescent-wistar-kyoto-rat-model-of-endogenous-depression-following-postweaning-social-isolation
#10
Reshma A Shetty, Monika Sadananda
In order to understand links that exist between inherited risk or predisposition, brain and behavioural development, endocrine regulation and social/environmental stimuli, animal models are crucial. The Wistar-Kyoto (WKY) rat has been shown to have validity as a model of adult and adolescent depression. While sex- and age-specific differences in some of the face, predictive and construct validities of the model such as depression-like behaviours have been established, anhedonia and anxiety using other induced anxiety paradigms such as elevated plus maze remain equivocal...
December 23, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/28008793/social-isolation-alters-central-nervous-system-monoamine-content-in-prairie-voles-following-acute-restraint
#11
Neal McNeal, Eden M Anderson, Deirdre Moenk, Diane Trahanas, Leslie Matuszewich, Angela J Grippo
Animal models have shown that social isolation and other forms of social stress lead to depressive- and anxiety-relevant behaviors, as well as neuroendocrine and physiological dysfunction. The goal of this study was to investigate the effects of prior social isolation on neurotransmitter content following acute restraint in prairie voles. Animals were either paired with a same-sex sibling or isolated for 4 weeks. Plasma adrenal hormones and ex vivo tissue concentrations of monoamine neurotransmitters and their metabolites were measured following an acute restraint stressor in all animals...
January 9, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/27932080/vitamin-c-impacts-anxiety-like-behavior-and-stress-induced-anorexia-relative-to-social-environment-in-smp30-gnl-knockout-mice
#12
Miwako Koizumi, Yoshitaka Kondo, Ayumi Isaka, Akihito Ishigami, Emiko Suzuki
The role of endogenous vitamin C (VC) in emotion and psychiatric measures has long been uncertain. We aimed to investigate how an individual's VC status impacts his or her mental health. Our hypothesis is that body VC levels modulate anxiety, anorexia, and depressive phenotypes under the influence of psychosocial rearing environments and sex. The VC status of senescence marker protein-30/gluconolactonase knockout mice, which lack the ability to synthesize VC, were continuously shifted from adequate (VC+) to depleted (VC-) by providing a water with or without VC...
December 2016: Nutrition Research
https://www.readbyqxmd.com/read/27917785/dipyrone-ameliorates-behavioural-changes-induced-by-unpredictable-chronic-mild-stress-gender-differences
#13
Olcay E Kiroğlu, Kübra E Demirkol, Fatih Berktaş, Arash A Yegani, Ayşegül Kirpik, Erkan Maytalman, Mahmut Ünverdi, Fazilet Aksu
PURPOSE: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects. METHODS: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27894930/sex-dependent-influence-of-chronic-mild-stress-cms-on-voluntary-alcohol-consumption-study-of-neurobiological-consequences
#14
Eva M Marco, Javier Antonio Ballesta, Carlos Irala, María-Donina Hernández, María Elisa Serrano, Virginia Mela, Meritxell López-Gallardo, María-Paz Viveros
Alcohol use disorder and depression are highly comorbid, and both conditions exhibit important sexual dimorphisms. Here, we aimed to investigate voluntary alcohol consumption after 6weeks of chronic mild stress (CMS) in Wistar rats - employed as an animal model of depression. Male and female rats were investigated, and changes in several molecular markers were analysed in frontal cortex (FCx) and hippocampal formation (HF). CMS induced depressive-like responses in the forced swimming test - increased immobility time - in male and female animals, without affecting anhedonia (sucrose preference test) nor motor activity (holeboard); body weight gain and food intake were diminished only among CMS males...
January 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27870451/preclinical-sex-differences-in-depression-and-antidepressant-response-implications-for-clinical-research
#15
REVIEW
Nikolaos Kokras, Christina Dalla
Women suffer from depression and anxiety disorders more often than men, and as a result they receive antidepressants to a greater extent. Sex differences in antidepressant response in humans have been modestly studied, and results have been controversial. At the same time, preclinical studies on animal models of depression and antidepressant response have provided insights with regard to sex differences that could be useful for the design and interpretation of future clinical trials. This Mini-Review discusses such sex-differentiated findings with regard to the presentation of depression, endophenotypes, and antidepressant response...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27870419/sex-differences-in-brain-derived-neurotrophic-factor-signaling-and-functions
#16
REVIEW
Chi Bun Chan, Keqiang Ye
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family that plays a critical role in numerous neuronal activities. Recent studies have indicated that some functions or action mechanisms of BDNF vary in a sex-dependent manner. In particular, BDNF content in some brain parts and the tendency to develop BDNF deficiency-related diseases such as depression are greater in female animals. With the support of relevant studies, it has been suggested that sex hormones or steroids can modulate the activities of BDNF, which may account for its functional discrepancy in different sexes...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27746208/analysis-of-inflammation-induced-depression-of-home-cage-wheel-running-in-rats-reveals-the-difference-between-opioid-antinociception-and-restoration-of-function
#17
Ram Kandasamy, Jonas J Calsbeek, Michael M Morgan
Opioids are effective at inhibiting responses to noxious stimuli in rodents, but have limited efficacy and many side effects in chronic pain patients. One reason for this disconnect is that nociception is typically assessed using withdrawal from noxious stimuli in animals, whereas chronic pain patients suffer from abnormal pain that disrupts normal activity. We hypothesized that assessment of home cage wheel running in rats would provide a much more clinically relevant method to assess opioid efficacy to restore normal behavior...
January 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27742580/mechanical-allodynia-corresponds-to-oprm1-downregulation-within-the-descending-pain-network-of-male-and-female-rats-exposed-to-neonatal-immune-challenge
#18
Siyang Yan, Amanda C Kentner
Exposure to painful procedures and/or stressors during the early neonatal period can reprogram the underlying neurocircuitry involved in nociception and neuropathic pain perception. The reprogramming of these systems can result in an enduring elevation in sensitivity towards mechanical and thermal stimuli. Recent evidence suggests that exposure to mild inflammatory mediators during the neonatal period can induce similar pain responses in both adolescent and adult rats. Therefore, we sought to profile changes in the expression of several genes across brain areas involved in the active modulation of nociception and neuropathic pain using a well-recognized model of neonatal inflammation...
October 11, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27696737/highly-polygenic-architecture-of-antidepressant-treatment-response-comparative-analysis-of-ssri-and-nri-treatment-in-an-animal-model-of-depression
#19
Karim Malki, Maria Grazia Tosto, Héctor Mouriño-Talín, Sabela Rodríguez-Lorenzo, Oliver Pain, Irfan Jumhaboy, Tina Liu, Panos Parpas, Stuart Newman, Artem Malykh, Lucia Carboni, Rudolf Uher, Peter McGuffin, Leonard C Schalkwyk, Kevin Bryson, Mark Herbster
Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized, with many genetic variants interacting in yet unclear ways. In this study we used methods that can automatically learn to detect patterns of statistical regularity from a sparsely distributed signal across hippocampal transcriptome measurements in a large-scale animal pharmacogenomic study to uncover genomic variations associated with AD. The study used four inbred mouse strains of both sexes, two drug treatments, and a control group (escitalopram, nortriptyline, and saline)...
April 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27567117/short-and-long-term-effects-of-stress-during-adolescence-on-emotionality-and-hpa-function-of-animals-exposed-to-alcohol-prenatally
#20
Charlis Raineki, Leanne Chew, Perry Mok, Linda Ellis, Joanne Weinberg
Prenatal alcohol exposure (PAE) is associated with extremely high rates of psychopathologies, which may be mediated by the hypothalamic-pituitary-adrenal (HPA) dysregulation observed in exposed individuals. Of relevance, PAE carries an increased risk of exposure to stressful environments throughout life. Importantly, stressful experiences during adolescence increase vulnerability to psychopathologies. However, little is known about how adolescent stressful experiences in the context of PAE-induced HPA dysregulation may further alter the developmental trajectory and potentially contribute to the disproportionally high rate of psychopathologies observed in this population...
December 2016: Psychoneuroendocrinology
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