Ellen Doney, Laurence Dion-Albert, Francois Coulombe-Rozon, Natasha Osborne, Renaud Bernatchez, Sam E J Paton, Fernanda Neutzling Kaufmann, Roseline Olory Agomma, José L Solano, Raphael Gaumond, Katarzyna A Dudek, Joanna Kasia Szyszkowicz, Manon Lebel, Alain Doyen, Audrey Durand, Flavie Lavoie-Cardinal, Marie-Claude Audet, Caroline Menard
BACKGROUND: Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestine, where absorption of most foods and drugs takes place...
January 2024: Biol Psychiatry Glob Open Sci