keyword
MENU ▼
Read by QxMD icon Read
search

"Endurant"

keyword
https://www.readbyqxmd.com/read/28944867/succinate-promotes-skeletal-muscle-protein-synthesis-via-erk1-2-signaling-pathway
#1
Yexian Yuan, Yaqiong Xu, Jingren Xu, Bingqing Liang, Xingcai Cai, Canjun Zhu, Lina Wang, Songbo Wang, Xiaotong Zhu, Ping Gao, Xiuqi Wang, Yongliang Zhang, Qingyan Jiang, Gang Shu
It is well known that endurance training is effective to attenuate skeletal muscle atrophy. Succinate is a typical TCA metabolite, of which exercise could dramatically increase the content. The present study aimed to investigate the effect of succinate on protein synthesis in skeletal muscle, and try to delineate the underlying mechanism. The in vitro study revealed that succinate dose‑dependently increased protein synthesis in C2C12 myotube along with the enhancement of phosphorylation levels of AKT Serine/Threonine Kinase 1(Akt), mammalian target of rapamycin, S6, eukaryotic translation initiation factor 4E, 4E binding protein 1 and forkhead box O (FoxO) 3a...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944813/transparent-amorphous-strontium-titanate-resistive-memories-with-transient-photo-response
#2
Taimur Ahmed, Sumeet Walia, Jeeson Kim, Hussein Nili, Rajesh Ramanathan, Edwin L H Mayes, Desmond W M Lau, Omid Kavehei, Vipul Bansal, Madhu Bhaskaran, Sharath Sriram
Transparent non-volatile memory devices are desirable for realizing visually-clear integrated systems for information storage. Optical transparency provides advantages in applications such as smart glass electronic devices and wearable electronics. However, achieving high transparency limits the choice of active layers as well as the electrodes; thereby, constraining device processing and performance. Here, we demonstrate bilayer transparent memory cells using room temperature deposited amorphous strontium titanate as the functional material and indium tin oxide electrodes...
September 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28944273/defining-the-determinants-of-endurance-running-performance-in-the-heat
#3
Carl A James, Mark Hayes, Ashley G B Willmott, Oliver R Gibson, Andreas D Flouris, Zachary J Schlader, Neil S Maxwell
In cool conditions, physiologic markers accurately predict endurance performance, but it is unclear whether thermal strain and perceived thermal strain modify the strength of these relationships. This study examined the relationships between traditional determinants of endurance performance and time to complete a 5-km time trial in the heat. Seventeen club runners completed graded exercise tests (GXT) in hot (GXTHOT; 32°C, 60% RH, 27.2°C WBGT) and cool conditions (GXTCOOL; 13°C, 50% RH, 9.3°C WBGT) to determine maximal oxygen uptake (V̇O2max), running economy (RE), velocity at V̇O2max (vV̇O2max), and running speeds corresponding to the lactate threshold (LT, 2 mmol...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28944269/sports-and-environmental-temperature-from-warming-up-to-heating-up
#4
REVIEW
Sébastien Racinais, Scott Cocking, Julien D Périard
Most professional and recreational athletes perform pre-conditioning exercises, often collectively termed a 'warm-up' to prepare for a competitive task. The main objective of warming-up is to induce both temperature and non-temperature related responses to optimize performance. These responses include increasing muscle temperature, initiating metabolic and circulatory adjustments, and preparing psychologically for the upcoming task. However, warming-up in hot and/or humid ambient conditions increases thermal and circulatory strain...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28944268/shivering-thermogenesis-in-humans-origin-contribution-and-metabolic-requirement
#5
REVIEW
François Haman, Denis P Blondin
As endotherms, humans exposed to a compensable cold environment rely on an increase in thermogenic rate to counteract heat lost to the environment, thereby maintaining a stable core temperature. This review focuses primarily on the most important contributor of heat production in cold-exposed adult humans, shivering skeletal muscles. Specifically, it presents current understanding on (1) the origins of shivering, (2) the contribution of shivering to total heat production and (3) the metabolic requirements of shivering...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28944229/targeting-trisomic-treatments-optimizing-dyrk1a-inhibition-to-improve-down-syndrome-deficits
#6
REVIEW
Megan Stringer, Charles R Goodlett, Randall J Roper
Overexpression of Dual-specificity tyrosine-phosphorylated regulated kinase 1A (DYRK1A), located on human chromosome 21, may alter molecular processes linked to developmental deficits in Down syndrome (DS). Trisomic DYRK1A is a rational therapeutic target, and although reductions in Dyrk1a genetic dosage have shown improvements in trisomic mouse models, attempts to reduce Dyrk1a activity by pharmacological mechanisms and correct these DS-associated phenotypes have been largely unsuccessful. Epigallocatechin-3-gallate (EGCG) inhibits DYRK1A activity in vitro and this action has been postulated to account for improvement of some DS-associated phenotypes that have been reported in preclinical studies and clinical trials...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28943974/relationships-between-self-perceptions-and-physical-activity-behaviour-fear-of-falling-and-physical-function-among-older-adults
#7
Myrla Sales, Pazit Levinger, Remco Polman
BACKGROUND: There has been a lack of research examining the relationship among self-perceptions, behaviour, cognitions and functioning in older adults. This study, therefore, examined the relationship between global and physical self-perceptions, physical activity behaviour, and fear of falling taking into considerations objective measures of physical functioning in community dwelling older adults. METHODS/DESIGN: Sixty-six participants between 60 and 90 years old (71...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28943486/endovascular-treatment-of-complex-aortic-disease-with-parallel-graft-endovascular-aneurysm-repair-retrospective-analysis-of-a-single-center-experience-and-midterm-results
#8
Adovasio Roberto, Chiarandini Stefano, Calvagna Cristiano, D'Oria Mario, Zamolo Francesca, Pipitone Marco Damiano, Sgorlon Giada
OBJECTIVES: We sought to evaluate the midterm results of parallel-graft-endovascular aneurysm repair (pg-EVAR) for complex aortic anatomy in high-risk candidates for open surgical repair of abdominal aortic aneurism (AAA). MATERIALS AND METHODS: Clinical and radiographic information on 35 patients treated by pg-EVAR between March 2010 and December 2015 was retrospectively reviewed and analyzed. All patients presented with symptomatic aneurysms and were treated within 3 days of clinical presentation...
September 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28943061/nutritional-strategies-in-ruminants-a-lifetime-approach
#9
REVIEW
Joseph McGrath, Stéphane M Duval, Luis F M Tamassia, Maik Kindermann, René T Stemmler, Vinícius N de Gouvea, Tiago S Acedo, Irmgard Immig, Scot N Williams, Pietro Celi
This review examines the role of nutritional strategies to improve lifetime performance in ruminants. Strategies to increase ruminants' productive longevity by means of nutritional interventions provide the opportunity not only to increase their lifetime performances and their welfare, but also to decrease their environmental impact. This paper will also address how such nutritional interventions can increase herd efficiency and farm profitability. The key competencies reviewed in this article are redox balance, skeletal development and health, nutrient utilization and sustainability, which includes rearing ruminants without antibiotics and methane mitigation...
September 12, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28942002/long-enduring-primary-hepatocyte-based-co-cultures-improve-prediction-of-hepatotoxicity
#10
Eric I Novik, Jacquelyn Dwyer, James K Morelli, Amit Parekh, Cheul Cho, Eitan Pludwinski, Anil Shrirao, Robert M Freedman, James S MacDonald, Zaid Jayyosi
The failure of drug candidates during clinical trials and post-marketing withdrawal due to Drug Induced Liver Injury (DILI), results in significant late-stage attrition in the pharmaceutical industry. Animal studies have proven insufficient to definitively predict DILI in the clinic, therefore a variety of in vitro models are being tested in an effort to improve prediction of human hepatotoxicity. The model system described here consists of cryopreserved primary rat, dog or human hepatocytes co-cultured together with a fibroblast cell line, which aids in the hepatocytes' maintenance of more in vivo-like characteristics compared to traditional hepatic mono-cultures, including long term viability and retention of activity of cytochrome P450 isozymes...
September 20, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28941809/lc-hrms-based-metabolomic-approach-for-the-detection-of-cera-s-effects-in-horse-doping-control
#11
Céline Joré, Benoît Loup, Patrice Garcia, Anne-Christelle Paris, Marie-Agnès Popot, Michel Audran, Yves Bonnaire, Emmanuelle Varlet-Marie, Ludovic Bailly-Chouriberry
Erythropoiesis Stimulating Agents (ESAs) were developed for therapeutic purposes to stimulate red blood cell (RBC) production. Consequently, tissue oxygenation is enhanced as athlete's endurance and ESAs misuse now benefits doping. Our hypothesis is that most of ESAs should have similar mechanisms and thus have the same effects on metabolism. Studying the metabolome variations could allow suspecting the use of any ESAs with a single method by targeting their effects. In this objective, a metabolomic study was carried out on 3 thoroughbred horses with a single administration of 4...
September 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28940820/non-invasive-ventilation-during-cycle-exercise-training-in-patients-with-chronic-respiratory-failure-on-long-term-ventilatory-support-a-randomized-controlled-trial
#12
Michele Vitacca, Dicle Kaymaz, Barbara Lanini, Guido Vagheggini, Pınar Ergün, Francesco Gigliotti, Nicolino Ambrosino, Mara Paneroni
BACKGROUND AND OBJECTIVE: The role of non-invasive ventilation (NIV) during exercise training (ET) in patients with chronic respiratory failure (CRF) is still unclear. The aim of this study was to test whether NIV during ET had an additional effect in increasing the 6-min walking distance (6MWD) and cycle endurance time compared with ET alone. METHODS: All patients underwent 20 sessions of cycle training over 3 weeks and were randomly assigned to ET with NIV or ET alone...
September 22, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28940309/-it-felt-like-violence-indigenous-knowledge-traditions-and-the-postcolonial-ethics-of-academic-inquiry-and-community-engagement
#13
Joseph P Gone
In a 2014 presentation at an academic conference featuring an American Indian community audience, I critically engaged the assumptions and commitments of Indigenous Research Methodologies. These methodologies have been described as approaches and procedures for conducting research that stem from long-subjugated Indigenous epistemologies (or "ways of knowing"). In my presentation, I described a Crow Indian religious tradition known as a skull medicine as an example of an indigenous way of knowing, referring to a historical photograph of a skull medicine bundle depicted on an accompanying slide...
September 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28939734/juvenile-solitary-confinement-as-a-form-of-child-abuse
#14
Andrew B Clark
Placing incarcerated juveniles into solitary confinement continues to occur in certain states of the United States, despite the accumulating evidence that it may cause substantial psychological damage to the teenagers who must endure it. The practice has been widely condemned by professional and human rights organizations, amid a growing appreciation of the immaturity and vulnerability of the adolescent brain. Although several states and the federal government have been successful in abolishing or dramatically reducing the use of juvenile solitary confinement, it remains common practice in many facilities...
September 2017: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/28939713/trends-in-racial-ethnic-disparities-in-cardiovascular-health-among-us-adults-from-1999-2012
#15
Lindsay R Pool, Hongyan Ning, Donald M Lloyd-Jones, Norrina B Allen
BACKGROUND: In the United States, there are persistent racial and ethnic disparities in cardiovascular disease morbidity and mortality. National efforts have focused on reducing these disparities; however, little is known about the long-term trends in racial/ethnic disparities in cardiovascular health (CVH). METHODS AND RESULTS: We included 11 285 adults aged ≥20 years from the National Health and Nutrition Examination Surveys survey cycles 1999/2000 through 2011/2012...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28939592/%C3%AE-ketoglutarate-prevents-skeletal-muscle-protein-degradation-and-muscle-atrophy-through-phd3-adrb2-pathway
#16
Xingcai Cai, Yexian Yuan, Zhengrui Liao, Kongping Xing, Canjun Zhu, Yaqiong Xu, Lulu Yu, Lina Wang, Songbo Wang, Xiaotong Zhu, Ping Gao, Yongliang Zhang, Qingyan Jiang, Pingwen Xu, Gang Shu
Skeletal muscle atrophy due to excessive protein degradation is the main cause for muscle dysfunction, fatigue, and weakening of athletic ability. Endurance exercise is effective to attenuate muscle atrophy, but the underlying mechanism has not been fully investigated. α-Ketoglutarate (AKG) is a key intermediate of tricarboxylic acid cycle, which is generated during endurance exercise. Here, we demonstrated that AKG effectively attenuated corticosterone-induced protein degradation and rescued the muscle atrophy and dysfunction in a Duchenne muscular dystrophy mouse model...
September 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28937802/epidemiology-of-stress-fractures-in-collegiate-student-athletes-2004-2005-through-2013-2014-academic-years
#17
Katherine H Rizzone, Kathryn E Ackerman, Karen G Roos, Thomas P Dompier, Zachary Y Kerr
CONTEXT:   Stress fractures are injuries caused by cumulative, repetitive stress that leads to abnormal bone remodeling. Specific populations, including female athletes and endurance athletes, are at higher risk than the general athletic population. Whereas more than 460 000 individuals participate in collegiate athletics in the United States, no large study has been conducted to determine the incidence of stress fractures in collegiate athletes. OBJECTIVE:   To assess the incidence of stress fractures in National Collegiate Athletic Association (NCAA) athletes and investigate rates and patterns overall and by sport...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28934747/untangling-longevity-dauer-and-healthspan-in-caenorhabditis-elegans-insulin-igf-1-signalling
#18
Collin Yvès Ewald, Jorge Iván Castillo-Quan, T Keith Blackwell
The groundbreaking discovery that lower levels of insulin/IGF-1 signaling (IIS) can induce lifespan extension was reported 24 years ago in the nematode Caenorhabditis elegans. In this organism, mutations in the insulin/IGF-1 receptor gene daf-2 or other genes in this pathway can double lifespan. Subsequent work has revealed that reduced IIS (rIIS) extends lifespan across diverse species, possibly including humans. In C. elegans, IIS also regulates development into the diapause state known as dauer, a quiescent larval form that enables C...
September 22, 2017: Gerontology
https://www.readbyqxmd.com/read/28934562/the-enduring-legacy-of-250-years-of-pharmacology-in-edinburgh
#19
John S Kelly, Angus V P Mackay
Two hundred fifty years ago, the University of Edinburgh appointed Francis Home to the first chair of materia medica, the accumulated knowledge of materials used in healing. Francis Home and his colleagues were determined to improve the quality of medical training in Edinburgh by introducing a final examination and compiling a catalog of medicines validated by the Royal College of Physicians of Edinburgh. The catalog, known as the Edinburgh Pharmacopoeia, was a great success, partly due to the orderly nature of its contents, its routine editing to eliminate worthless entries, and the introduction of new treatments whose preparation was precisely documented...
September 13, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28933843/cspb0-9sn0-1ibr2-based-all-inorganic-perovskite-solar-cells-with-exceptional-efficiency-and-stability
#20
Jia Liang, Peiyang Zhao, Caixing Wang, Yanrong Wang, Yi Hu, Guoyin Zhu, Lianbo Ma, Jie Liu, Zhong Jin
The emergence of perovskite solar cells (PSCs) has generated enormous interests in the photovoltaic research community. Recently, cesium metal halides (CsMX3, M = Pb or Sn; X = I, Br, Cl or mixed halides) as a class of inorganic perovskites showed great promise for PSCs and other optoelectronic devices. However, CsMX3-based PSCs usually exhibit lower power conversion efficiencies (PCEs) than organic-inorganic hybrid PSCs, due to the unfavorable bandgaps. Herein, a novel mixed-Pb/Sn mixed-halide inorganic perovskite, CsPb0...
September 21, 2017: Journal of the American Chemical Society
keyword
keyword
86421
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"