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REVIEW
Yuejin Ji, Hongxiao Li, Guoliang Dai, Xu Zhang, Wenzheng Ju
BACKGROUND AND AIM: Depression is highly prevalent in patients with inflammatory bowel disease (IBD), which may affect the prognosis of IBD. This aimed to investigate the impact of depression on prognosis in IBD. METHODS: A systematic literature search was performed in four databases (Medline, Embase, Web of Science, and PsycINFO) up to December 31, 2023. Studies were included if they investigated the impact of depression on prognosis in IBD. The primary outcome was flare in IBD, and secondary outcomes were hospitalization, readmission, emergency visits, surgery, and escalation of medical therapy...
April 24, 2024: Journal of Gastroenterology and Hepatology
#2
JOURNAL ARTICLE
Lara-Lynn Hautle, Jennifer Kurath, Lena Jellestad, Antonia M Lüönd, Tanja S H Wingenbach, Billy Jansson, Monique C Pfaltz
Previous studies report a preference for larger comfortable interpersonal distance (CIPD) in individuals with child maltreatment (CM) when being approached by others. Yet, research on approaching others, as opposed to being approached, as well as on potential effects of social anxiety and depression is lacking. We investigated if CM and depressive symptoms influence CIPD and if social anxiety mediates the possible association of CM and CIPD when approaching a female stranger. One hundred ten participants with CM (CM) and 58 participants without CM (non-CM) experiences performed the stop-distance paradigm and stopped first when feeling uncomfortable (D1) and again when feeling very uncomfortable (D2)...
April 23, 2024: British Journal of Psychology
#3
JOURNAL ARTICLE
Chantal P Delaquis, Nathalie Godart, Caroline Barry, Damien Ringuenet, Anne-Solène Maria, Isabelle Nicolas, Sylvie Berthoz
OBJECTIVE: Previous studies have highlighted the relevance of perfectionism, self-esteem, and anxio-depressive symptoms in anorexia nervosa (AN). However, the relationships between these factors and cardinal eating disorders (ED) symptoms remain unclear, particularly in AN subtypes. This study aimed to examine their interconnections using network analysis. METHOD: The sample included n = 338 inpatients with AN who completed the Eating Disorder Examination Questionnaire, Frost Multidimensional Perfectionism Scale, Rosenberg Self-Esteem Scale, and Hospital Anxiety and Depression Scale...
April 22, 2024: Journal of Clinical Psychology
#4
JOURNAL ARTICLE
Alice Di Paolo, Valentina Membrino, Sonila Alia, Laura Nanetti, Lucia Emanuela Svarca, Massimo Leone Perrone, Luca Aquilanti, Laura Mazzanti, Arianna Vignini, Eleonora Salvolini, Michele Severini
Anorexia nervosa (AN) is a complex disorder affecting mainly, but not only, teenagers. Researchers agree that AN is deeply associated with a pro-inflammatory state following an impaired immune system, resulting from altered levels of cytokines such as IL-1β and TNF-α, also impacted by the frequent depressive states. Thus, the aim of the present case-control study was to evaluate the relationship between patients suffering from AN undergoing specialized eating disorder (ED) treatment for AN and pro-inflammatory cytokines...
April 19, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
#5
JOURNAL ARTICLE
Alicia Alpuente, Victor J Gallardo, Laila Asskour, Edoardo Caronna, Marta Torres-Ferrus, Patricia Pozo-Rosich
BACKGROUND: Migraine is a complex neurological disorder with significant heterogeneity in its clinical presentation and molecular mechanisms. Calcitonin gene-related peptide (CGRP) has emerged as a key player in migraine pathophysiology, but challenges remain in its utilization as a biomarker. This study aimed to investigate salivary CGRP levels during migraine attacks across the frequency spectrum and explore associations with clinical variables. METHODS: A prospective longitudinal pilot study was conducted, recruiting migraine patients from an outpatient headache clinic...
April 18, 2024: Journal of Headache and Pain
#6
JOURNAL ARTICLE
Sophie Breunig, Jeremy M Lawrence, Isabelle F Foote, Hannah J Gebhardt, Erik G Willcutt, Andrew D Grotzinger
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with diagnostic criteria requiring symptoms to begin in childhood. We investigated whether individuals diagnosed as children differ from those diagnosed in adulthood with respect to shared and unique architecture at the genome-wide and gene expression level of analysis. METHODS: We used genomic structural equation modeling (SEM) to investigate differences in genetic correlations ( r g ) of childhood-diagnosed ( n cases = 14,878) and adulthood-diagnosed ( n cases = 6961) ADHD with 98 behavioral, psychiatric, cognitive, and health outcomes...
May 2024: Biol Psychiatry Glob Open Sci
#7
JOURNAL ARTICLE
Yuhan Zhang, Wei Xu, Dean McDonnell, Jin-Liang Wang
BACKGROUND: While childhood maltreatment is understood to be a significant risk factor for adolescent internalizing problems (depression and anxiety), underlying mechanisms linking each type of maltreatment to internalizing problems in adolescents remain unclear. Moreover, the current state of knowledge regarding the associations between maladaptive cognitive emotion regulation strategies and each type of maltreatment, as well as their impact on adolescent internalizing problems, is limited...
April 16, 2024: Child Abuse & Neglect
#8
JOURNAL ARTICLE
Jon Berner, Animesh Acharjee
Depression is a disorder with variable presentation. Selecting treatments and dose-finding is, therefore, challenging and time-consuming. In addition, novel antidepressants such as ketamine have sparse optimization evidence. Insights obtained from metabolomics may improve the management of patients. The objective of this study was to determine whether compounds in the cerebrospinal fluid (CSF) metabolome correlate with scores on questionnaires and response to medication. We performed a retrospective pilot study to evaluate phenotypic and metabolomic variability in patients with treatment-resistant depression using multivariate data compression algorithms...
April 17, 2024: Discov Ment Health
#9
JOURNAL ARTICLE
Cynthia Yi-An Chen, Chih-Chiang Chiu, Cho-Yin Huang, Ying-Chih Cheng, Ming-Chyi Huang, Po-Hsiu Kuo, Wen-Yin Chen
BACKGROUND: Cognitive impairment is a growing problem with increasing burden in global aging. Older adults with major depressive disorder (MDD) have higher risk of dementia. Neurofilament light chain (NfL) has been proven as a potential biomarker in neurodegenerative disease, including dementia. We aimed to investigate the association between cognitive deficits and NfL levels in older adults with MDD. METHODS: In this cross-sectional study, we enrolled 39 MDD patients and 15 individuals with mild neurocognitive disorder or major neurocognitive disorder, Alzheimer's type, as controls, from a tertiary psychiatric hospital...
April 16, 2024: BMC Geriatrics
#10
REVIEW
Anne Duffy, Paul Grof
BACKGROUND: Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research. Prospective studies of well-characterized patients and their family members have identified lithium responsive (LiR) and lithium non-responsive (LiNR) subtypes that hold promise for advancement. METHOD: In this narrative review, relevant observations from published longitudinal studies of well-characterized bipolar patients and their families spanning six decades are highlighted...
April 12, 2024: International Journal of Bipolar Disorders
#11
JOURNAL ARTICLE
Facundo Pereyra, Luis María Bustos Fernández, Francisco Schlottmann, Rafael Zamora, Agustina Marconi, Leandro Steinberg, Lisandro Pereyra
BACKGROUND: Irritable bowel syndrome (IBS) is a functional disorder commonly associated with extra-intestinal symptoms. However, the prevalence of these symptoms according to IBS subtype is not well established. AIM: To compare the prevalence of extra-intestinal symptoms among patients with different subtypes of IBS. METHODS: A descriptive cross-sectional study including patients with IBS according to Rome IV criteria was performed between July 2022 and April 2023...
April 12, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#12
JOURNAL ARTICLE
Shengkai Ji, Chen Chen
INTRODUCTION: Preschool teachers' mental health may be a critical factor in their job performance, which in turn can influence the quality of early childhood education. However, little is known about its development. Childhood maltreatment, as a chronic form of childhood stress, may influence later mental health development. Although large, comprehensive research has been undertaken on childhood maltreatment and mental health, the associations between these two variables need further exploration...
2024: Frontiers in Psychology
#13
JOURNAL ARTICLE
Kosuke Hagiwara, Chong Chen, Ryo Okubo, Sumiyo Okawa, Shin Nakagawa, Takahiro Tabuchi
BACKGROUND: Mother-to-infant bonding (MIB) is foundational for nurturing behaviors and an infant's development. Identifying risk factors for difficulties or problems in MIB is vital. However, traditional research often dichotomizes MIB using cutoff thresholds, overlooking its underlying complexities. This research utilizes latent profile analysis (LPA) to discern MIB subtypes in a nationwide Japanese dataset. METHODS: We conducted LPA on data from the Mother-to-Infant Bonding Scale (MIBS), collected from 3,877 postpartum women within one year of childbirth...
April 11, 2024: Archives of Women's Mental Health
#14
JOURNAL ARTICLE
Jing-Yi Long, Kun Qin, Nanfang Pan, Wen-Liang Fan, Yi Li
BACKGROUND: Major depressive disorder (MDD) has been increasingly understood as a disruption of brain connectome. Investigating grey matter structural networks with a large sample size can provide valuable insights into the structural basis of network-level neuropathological underpinnings of MDD. AIMS: Using a multisite MRI data-set including nearly 2000 individuals, this study aimed to identify robust topology and connectivity abnormalities of grey matter structural network linked to MDD and relevant clinical phenotypes...
April 11, 2024: British Journal of Psychiatry
#15
REVIEW
Mounica Thootkur, Binx Yezhe Lin, Akhil S Pola, Alexander Zhang, Zhengshan Liu, Michael Greenage, Justin White, Mamta Sapra
As global aging becomes more prominent, neurocognitive disorders (NCD) incidence has increased. Patients with NCD usually have an impairment in one or more cognitive domains, such as attention, planning, inhibition, learning, memory, language, visual perception, and spatial or social skills. Studies indicate that 50-80% of these adults will develop neuropsychiatric symptoms (NPS), such as apathy, depression, anxiety, disinhibition, delusions, hallucinations, and aberrant motor behavior. The progression of NCD and subsequent NPS requires tremendous care from trained medical professionals and family members...
April 4, 2024: Psychopharmacology Bulletin
#16
JOURNAL ARTICLE
Yoshikazu Maeno, Manabu Fuchikami, Koichiro Fujimaki, Israel Liberzon, Shigeru Morinobu
Handling human remains is extremely difficult and stressful task, and it can contribute to the development of stress-related mental health problems. To prevent disaster from the development of mental disorders in first responders, it will be important to elucidate factors sustaining psychological well-being following the events requiring handling of human remains. Japanese Ground Self-Defense Forces (JGSDF) first responders (n = 146), involved in human remains recovery after the Great East Japan Earthquake (GEJE) participated...
March 24, 2024: Journal of Psychiatric Research
#17
JOURNAL ARTICLE
Felix Waitzmann, Yue Kris Wu, Julijana Gjorgjieva
Cortical dynamics and computations are strongly influenced by diverse GABAergic interneurons, including those expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP). Together with excitatory (E) neurons, they form a canonical microcircuit and exhibit counterintuitive nonlinear phenomena. One instance of such phenomena is response reversal, whereby SST neurons show opposite responses to top-down modulation via VIP depending on the presence of bottom-up sensory input, indicating that the network may function in different regimes under different stimulation conditions...
April 16, 2024: Proceedings of the National Academy of Sciences of the United States of America
#18
JOURNAL ARTICLE
Jin-Jie Xu, Xue-Quan Zhu, Shuang Liu, Lu-Yu Ding, Bing-Bing Fu, Cong-Cong Sun, Yan-Li Pan, Wei Wang, Ling Zhang
BACKGROUND: Rapid cycling bipolar disorder (RCBD), characterized by four or more episodes per year, is a complex subtype of bipolar disorder (BD) with poorly understood characteristics. METHOD: This multicenter, observational, longitudinal cohort study enrolled 520 BD patients across seven psychiatric institutions in China from January 2013 to January 2014. Participants were divided into RCBD and non-RCBD (NRCBD) groups based on the frequency of mood episodes in the preceding year...
April 9, 2024: International Journal of Bipolar Disorders
#19
JOURNAL ARTICLE
Lily D Yan, Rodney Sufra, Reichling St Sauveur, Marie Christine Jean-Pierre, Alexandra Apollon, Rodolphe Malebranche, Michel Théard, Gerard Pierre, Jessy Dévieux, Jennifer Lau, Nour Mourra, Nicholas L S Roberts, Rehana Rasul, Denis Nash, Altaf M Pirmohamed, Richard B Devereux, Myung Hee Lee, Gene F Kwan, Monika M Safford, Lauré Adrien, Jean Patrick Alfred, Marie Deschamps, Patrice Severe, Daniel W Fitzgerald, Jean W Pape, Vanessa Rouzier, Margaret L McNairy
BACKGROUND: Eighty percent of global cardiovascular disease (CVD) is projected to occur in low- and middle -income countries (LMICs), yet local epidemiological data are scarce. We provide the first population-based, adjudicated CVD prevalence estimates in Port-au-Prince, Haiti to describe the spectrum of heart disease and investigate associated risk factors. METHODS: Demographic, medical history, clinical, imaging and laboratory data were collected among adults recruited using multistage random sampling from 2019 to 2021...
May 2024: Lancet Reg Health Am
#20
JOURNAL ARTICLE
Felicity Liew, Claudia Efstathiou, Sara Fontanella, Matthew Richardson, Ruth Saunders, Dawid Swieboda, Jasmin K Sidhu, Stephanie Ascough, Shona C Moore, Noura Mohamed, Jose Nunag, Clara King, Olivia C Leavy, Omer Elneima, Hamish J C McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Victoria C Harris, Linzy Houchen-Wolloff, Neil J Greening, Nazir I Lone, Matthew Thorpe, A A Roger Thompson, Sarah L Rowland-Jones, Annemarie B Docherty, James D Chalmers, Ling-Pei Ho, Alexander Horsley, Betty Raman, Krisnah Poinasamy, Michael Marks, Onn Min Kon, Luke S Howard, Daniel G Wootton, Jennifer K Quint, Thushan I de Silva, Antonia Ho, Christopher Chiu, Ewen M Harrison, William Greenhalf, J Kenneth Baillie, Malcolm G Semple, Lance Turtle, Rachael A Evans, Louise V Wain, Christopher Brightling, Ryan S Thwaites, Peter J M Openshaw
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1 . Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment...
April 2024: Nature Immunology
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