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Depression subtypes

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https://www.readbyqxmd.com/read/28219707/22-azidosalvinorin-a-exhibits-antidepressant-like-effect-in-mice
#1
James Oluwagbamigbe Fajemiroye, Polepally Reddy Prabhakar, Carlos Luiz da Cunha, Elson Alves Costa, Jordan K Zjawiony
The increasing cases of depression has made the searches for new drugs and understanding of the underligning neurobiology of this psychiatric disorder a necessity. Here, we modified the structure of salvinorin A (a known halucinogen) and investigated antidepressant-like activity of its four derivatives; 22-methylsulfanylsalvinorin A(SA1), 2-O-cinnamoylsalvinorin B (CSB), 22-azidosalvinorin A (SA2), and 2-O-(4(')-azidophenylsulfonyl)salvinorin B (SA3). Prior to behavioural tests (Irwin test, open field test - OFT, forced swimming test - FST and tail suspension test - TST), SA1 was prepared by reacting salvinorin B and methylthioacetic acid with 89% yield; CSB was obtained from the reaction of salvinorin B and cinnamic acid with 92% yield; SA2 was obtained from the reaction of salvinorin B and azidoacetic acid with 81% yield; and SA3 was prepared by reacting salvinorin B with 4-azidophenylsulfonyl chloride with 80% yield...
February 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28207917/the-role-of-ect-in-posttraumatic-stress-disorder-a-systematic-review
#2
Nagy A Youssef, W Vaughn McCall, Chittaranjan Andrade
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with a high burden of disability and mortality and frequently is treatment resistant. There is little to offer patients who are not responding to standard interventions. Thus, the objective of this report is to systematically review human data on whether electroconvulsive therapy (ECT) is effective in PTSD. METHODS: We performed a systematic literature review from 1958 through August 2016 for clinical studies and case reports published in English examining the efficacy of ECT in improving PTSD symptoms...
February 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28203083/sexual-dimorphism-in-parkinson-s-disease-differences-in-clinical-manifestations-quality-of-life-and-psychosocial-functioning-between-males-and-females
#3
Farzaneh Farhadi, Kia Vosoughi, Gholam Ali Shahidi, Ahmad Delbari, Johan Lökk, Seyed-Mohammad Fereshtehnejad
INTRODUCTION: Sex-related differences in clinical manifestations and consequences of Parkinson's disease (PD) have been poorly explored. Better understanding of sexual dimorphism in neurologic diseases such as PD has been announced as a research priority. The aim of our study was to determine independent sex differences in clinical manifestations and subtypes, psychosocial functioning, quality of life (QoL) and its domains between male and female individuals with PD. PATIENTS AND METHODS: A comprehensive list of demographics, motor symptoms and subtypes, nonmotor features, health-related quality of life (HRQoL), psychosocial functioning and general aspects of daily life was assessed in 157 individuals (108 males and 49 females) with idiopathic PD...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28194935/a-potential-pet-radiotracer-for-the-5-ht2c-receptor-synthesis-and-in-vivo-evaluation-of-4-3-18-f-fluorophenethoxy-pyrimidine
#4
Juhyeon Kim, Byung Seok Moon, Byung Chul Lee, Ho-Young Lee, Hak Joong Kim, Hyunah Choo, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min
The serotonin 2C receptor subtype (5-HT2C) is an excitatory 5-HT receptor widely distributed throughout the central nerve system. As the 5-HT2C receptor displays multiple actions on various neurotransmitter systems including glutamate, dopamine, epinephrine and -aminobutyric acid (GABA), abnormalities of the 5-HT2C receptor are associated with psychiatric diseases such as depression, schizophrenia, drug abuse, and anxiety. Up to date, three kinds of 5-HT2C PET radiotracers such as [11C]N-methylated arylazepine (1), [11C]WAY-163909 (2), [18F]fluorophenylcyclopropane (3) have been developed, but they may not be suitable for in vivo 5-HT2C imaging study due to their modest specific binding...
February 14, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28187293/assessing-the-contributions-of-childhood-maltreatment-subtypes-and-depression-case-control-status-on-telomere-length-reveals-a-specific-role-of-physical-neglect
#5
John Vincent, Iiris Hovatta, Souci Frissa, Laura Goodwin, Matthew Hotopf, Stephani L Hatch, Gerome Breen, Timothy R Powell
BACKGROUND: Studies have provided evidence that both childhood maltreatment and depressive disorders are associated with shortened telomere lengths. However, as childhood maltreatment is a risk factor for depression, it remains unclear whether this may be driving shortened telomere lengths observed amongst depressed patients. Furthermore, it's unclear if the effects of maltreatment on telomere length shortening are more pervasive amongst depressed patients relative to controls, and consequently whether biological ageing may contribute to depression's pathophysiology...
February 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28178703/the-impact-of-depression-on-the-development-of-mild-cognitive-impairment-over-3-years-of-follow-up-a-population-based-study
#6
Elvira Lara, Ai Koyanagi, Joan Domènech-Abella, Marta Miret, Jose Luis Ayuso-Mateos, Josep Maria Haro
BACKGROUND/AIMS: In the absence of effective treatments for dementia, major efforts are being directed towards identifying the risk factors of the prodromal phase of the disease. We report the incidence rates of mild cognitive impairment (MCI) in a Spanish population sample and assess the effect of depression at baseline on incident MCI (or MCI subtypes) at a 3-year follow-up. METHODS: A total of 1,642 participants (age ≥50 years) were examined as part of a Spanish nationally representative longitudinal study...
February 9, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28176009/dopamine-and-serotonin-modulation-of-motor-and-non-motor-functions-of-the-non-human-primate-striato-pallidal-circuits-in-normal-and-pathological-states
#7
REVIEW
Véronique Sgambato-Faure, Léon Tremblay
Thanks to the non-human primate (NHP), we have shown that the pharmacological disturbance of the anterior striatum or of external globus pallidus triggers a set of motivation and movement disorders, depending on the functional subterritory involved. One can, therefore, assume that the aberrant activity of the different subterritories of basal ganglia (BG) could lead to different behavioral disorders in neuropsychiatric disorders as Tourette's syndrome and Parkinson's disease. We are now addressing in the NHP the impact of modulating dopamine or serotonin within the BG on behavioral disorders...
February 7, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28170383/erratum-resting-state-connectivity-biomarkers-define-neurophysiological-subtypes-of-depression
#8
Andrew T Drysdale, Logan Grosenick, Jonathan Downar, Katharine Dunlop, Farrokh Mansouri, Yue Meng, Robert N Fetcho, Benjamin Zebley, Desmond J Oathes, Amit Etkin, Alan F Schatzberg, Keith Sudheimer, Jennifer Keller, Helen S Mayberg, Faith M Gunning, George S Alexopoulos, Michael D Fox, Alvaro Pascual-Leone, Henning U Voss, B J Casey, Marc J Dubin, Conor Liston
No abstract text is available yet for this article.
February 7, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28163934/enhancing-nmda-receptor-function-recent-progress-on-allosteric-modulators
#9
REVIEW
Lulu Yao, Qiang Zhou
The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer's disease. Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs. In light of the discovery of NMDAR hypofunction in psychiatric disorders and perhaps Alzheimer's disease, efforts in boosting NMDAR activity/functions have surged in recent years...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28160607/overlap-between-irritable-bowel-syndrome-and-functional-dyspepsia-including-subtype-analyses
#10
Yoon Jin Choi, Nayoung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Yong Sung Kim, Dong Ho Lee, Hyun Chae Jung
BACKGROUND AND AIM: Coexistent gastrointestinal symptom profiles and prevalence or associated factors for the overlap between each functional dyspepsia (FD) and irritable bowel syndrome (IBS) group remain unclear. Thus, the aim of the present study was to evaluate the clinicodemographic features of FD, IBS, and IBS-FD overlap and assess the risk factors thereof, including subtype and genetic polymorphisms for IBS-FD. METHODS: Consecutive patients were enrolled from the outpatient Gastroenterology clinics of Bundang Seoul National University Hospitals in Korea...
February 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28155205/a-pilot-study-to-determine-whether-combinations-of-objectively-measured-activity-parameters-can-be-used-to-differentiate-between-mixed-states-mania-and-bipolar-depression
#11
Jan Scott, Arne E Vaaler, Ole Bernt Fasmer, Gunnar Morken, Karoline Krane-Gartiser
BACKGROUND: Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studies that assessed activity parameters reported only mean levels rather than complexity or predictability of activity. We identified cases presenting in one of three acute phases of bipolar disorder and examined whether the application of non-linear dynamic models to the description of objectively measured activity can be used to predict case classification...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28150939/antinociceptive-effects-of-a-novel-%C3%AE-2-%C3%AE-3-subtype-selective-gabaa-receptor-positive-allosteric-modulator
#12
Lakeisha A Lewter, Janet L Fisher, Justin N Siemian, Kashi Reddy Methuku, Michael M Poe, James M Cook, Jun-Xu Li
Pain remains a challenging clinical condition and spinal GABAA receptors are crucial modulators of pain processing. α2/α3-subtype GABAA receptors mediate the analgesic actions of benzodiazepines. Positive allosteric modulators (PAMs) at α2/α3-subtype GABAA receptors may have analgesic potential. Here we report a new selective α2/α3-subtype GABAA receptor PAM in in vitro and in vivo pain assays. KRM-II-81 demonstrated similar efficacy at α1/α2/α3 GABAA receptors and negligible efficacy at α4/α5/α6 GABAA receptors, with α2 and α3-subtypes being 17- and 28-fold more potent than α1 subtypes in HEK-293T cells expressing GABAA receptors with different α subunits...
February 2, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28144891/the-course-of-anxiety-depression-and-unmet-needs-in-survivors-of-diffuse-large-b-cell-lymphoma-and-multiple-myeloma-in-the-early-survivorship-period
#13
Devesh Oberoi, Victoria White, John Seymour, H Miles Prince, Simon Harrison, Michael Jefford, Ingrid Winship, David Hill, Damien Bolton, Anne Kay, Jeremy Millar, Nicole Wong Doo, Graham Giles
PURPOSE: The purpose of the study is to examine the course of anxiety, depression and unmet needs in diffuse large B cell lymphoma (DLBCL) and multiple myeloma (MM) survivors in the first 2 years post diagnosis. METHODS: DLBCL and MM survivors, recruited through the Victorian Cancer Registry, completed two interviews approximately 7 and 15 months post diagnosis. Hospital Anxiety and Depression Scale (HADS) and Supportive Care Needs Survey (SCNS-SF34) were completed at both interviews...
January 31, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28142081/heterogeneity-in-patterns-of-dsm-5-posttraumatic-stress-disorder-and-depression-symptoms-latent-profile-analyses
#14
Ateka A Contractor, Michelle E Roley-Roberts, Susan Lagdon, Cherie Armour
BACKGROUND: Posttraumatic stress disorder (PTSD) and depression co-occur frequently following the experience of potentially traumatizing events (PTE; Morina et al., 2013). A person-centered approach to discern heterogeneous patterns of such co-occurring symptoms is recommended (Galatzer-Levy and Bryant, 2013). We assessed heterogeneity in PTSD and depression symptomatology; and subsequently assessed relations between class membership with psychopathology constructs (alcohol use, distress tolerance, dissociative experiences)...
January 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28137342/differential-effects-of-patient-symptom-subtypes-on-informal-hospice-caregiver-depression
#15
Chelsey M Wilkes, Karla T Washington, William M Palmer, Debra Parker Oliver, George Demiris, Kevin Craig
OBJECTIVE: Researchers sought to determine the extent to which burden related to patients' symptom subtypes could predict informal hospice caregiver depression, and to illustrate the differences between caregivers who experience suicidal ideation and those who do not. METHOD: Informal caregivers recruited from a not-for-profit community-based hospice agency participated in a cross-sectional survey. Self-report questionnaires assessed caregiver burden associated with patient symptomatology (via a modified version of the Memorial Symptom Assessment Scale-Short Form) and caregiver depressive symptoms, including suicidal ideation (measured by the Patient Health Questionnaire-9)...
January 31, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28133972/phenotypes-of-sleeplessness-stressing-the-need-for-psychodiagnostics-in-the-assessment-of-insomnia
#16
Merijn van de Laar, Tim Leufkens, Bart Bakker, Dirk Pevernagie, Sebastiaan Overeem
Insomnia is a too general term for various subtypes that might have different etiologies and therefore require different types of treatment. In this explorative study we used cluster analysis to distinguish different phenotypes in 218 patients with insomnia, taking into account several factors including sleep variables and characteristics related to personality and psychiatric comorbidity. Three clusters emerged from the analysis. The 'moderate insomnia with low psychopathology'-cluster was characterized by relatively normal personality traits, as well as normal levels of anxiety and depressive symptoms in the presence of moderate insomnia severity...
January 30, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28131002/an-exploratory-study-of-the-heterogeneity-of-the-jealousy-phenomenon-and-its-associations-with-affective-temperaments-and-psychopathological-dimensions-in-a-large-brazilian-sample
#17
Amanda B Lima, Cristiano A Köhler, Brendon Stubbs, João Quevedo, Thomas N Hyphantis, Ai Koyanagi, Donatella Marazziti, Jair C Soares, Eduard Vieta, André F Carvalho
BACKGROUND: Jealousy is a heterogenous emotion on a spectrum from normality to psychopathology. The relationship between different jealousy subtypes/dimensions and affective temperaments remain unknown. In addition, few large surveys have investigated the associations between jealousy subtypes and psychopathological dimensions. METHODS: A Brazilian Portuguese version of the "Questionario della Gelosia" (QUEGE) was developed. We obtained data from an anonymous web-based research platform...
January 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28128231/body-mass-index-moderates-the-relationship-between-c-reactive-protein-and-depressive-symptoms-evidence-from-the-china-health-and-retirement-longitudinal-study
#18
Tingting Qin, Wenhua Liu, Minghui Yin, Chang Shu, Mingming Yan, Jianyuan Zhang, Ping Yin
The present study aimed to investigate the role of abnormal body mass index (BMI, kg/m(2)) in the depression-CRP (C-reactive protein) relationship in a healthy middle-aged and elderly Chinese population. Analytical samples were drawn from the China Health and Retirement Longitudinal Study (CHARLS), and participants were categorized by different BMI levels. Depressive subtypes were evaluated both at baseline and follow-up using the Center for Epidemiology Studies Depression scale. Hs-CRP and other variables were measured at baseline...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28124233/american-tertiary-clinic-referred-bipolar-ii-disorder-versus-bipolar-i-disorder-associated-with-hastened-depressive-recurrence
#19
Bernardo Dell'Osso, Saloni Shah, Dennis Do, Laura D Yuen, Farnaz Hooshmand, Po W Wang, Shefali Miller, Terence A Ketter
BACKGROUND: Bipolar disorder (BD) is a chronic, frequently comorbid condition characterized by high rates of mood episode recurrence and suicidality. Little is known about prospective longitudinal characterization of BD type II (BD II) versus type I (BD I) in relation to time to depressive recurrence and recovery from major depressive episode. We therefore assessed times to depressive recurrence/recovery in tertiary clinic-referred BD II versus I patients. METHODS: Outpatients referred to Stanford BD Clinic during 2000-2011 were assessed with Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation and with Clinical Monitoring Form during up to 2 years of naturalistic treatment...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28121394/symptoms-of-major-depression-their-stability-familiality-and-prediction-by-genetic-temperamental-and-childhood-environmental-risk-factors
#20
Kenneth S Kendler, Steven H Aggen
BACKGROUND: Psychiatry has long sought to develop biological diagnostic subtypes based on symptomatic differences. This effort assumes that symptoms reflect, with good fidelity, underlying etiological processes. We address this question for major depression (MD). METHODS: We examine, in twins from a population-based registry, similarity in symptom endorsement in individuals meeting criteria for last-year MD at separate interview waves and in concordant twin pairs...
January 25, 2017: Depression and Anxiety
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