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JOURNAL ARTICLE
Fangming Xu, Yu Su, Xiaobo Wang, Tianle Zhang, Tingting Xie, Yumei Wang
STUDY DESIGN: A prospective study. BACKGROUND: This study aims to investigate the relationship between different states of bipolar disorder (BD) and plasma inflammatory proteins, which may be used as their biomarkers. MATERIALS AND METHODS: We totally collected admission plasma from 16 healthy subjects and 32 BD patients, including 16 patients with BD manic episodes (BD-M) and 16 patients with BD depressive episodes (BD-D). Ten samples in each group were analyzed by proximity extension assays of 92 inflammation-related proteins, and all samples were verified by ELISA...
March 13, 2024: International Immunopharmacology
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JOURNAL ARTICLE
Shiv Verma, Vaibhav Singh, VijayKrishna Nagampalli, Lee E Ponsky, Chiang-Shan R Li, Herta Chao, Sanjay Gupta
Men with prostate cancer are at increased risk of developing cognitive decline by the use of second-generation androgen signaling inhibitors. To date, reliable and sensitive biomarkers that could distinguish men at high risk of cognitive dysfunction under androgen deprivation therapy (ADT) have not been characterized. We used high-throughput transcriptional profiling utilizing human prostate cancer cell culture models mimicking ADT, biomarker selection using minimal common oncology data elements-cytoscape, and bioinformatic analyses employing Advaita® iPathwayGuide and DisGeNET for identification of disease-related gene associations...
March 14, 2024: Molecular Carcinogenesis
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JOURNAL ARTICLE
Shant Tamazian, Cory L Simpson
Darier disease is an autosomal dominant blistering disorder linked to mutation of the endoplasmic reticulum calcium pump, SERCA2, which compromises keratinocyte adhesion and differentiation. Beyond the typical keratotic and eroded skin lesions, patients with Darier disease often present with psychiatric co-morbidities. Herein, we present a biopsy-confirmed case of Darier disease in a patient with bipolar disorder, whose cutaneous disease dramatically worsened upon initiation of lithium therapy. In consultation with the patient's psychiatrist, lithium was tapered, leading to rapid improvement in her skin...
October 15, 2023: Dermatology Online Journal
#24
JOURNAL ARTICLE
Magdalena Brunner, Luisa Lang, Louisa Künkel, Dido Weber, Motahareh Solina Safari, Gabriele Baier-Bitterlich, Stephanie Zur Nedden
We recently identified PKN1 as a developmentally active gatekeeper of the transcription factor neuronal differentiation-2 (NeuroD2) in several brain areas. Since NeuroD2 plays an important role in amacrine cell (AC) and retinal ganglion cell (RGC) type formation, we aimed to study the expression of NeuroD2 in the postnatal retina of WT and Pkn1-/- animals, with a particular focus on these two cell types. We show that PKN1 is broadly expressed in the retina and that the gross retinal structure is not different between both genotypes...
February 29, 2024: International Journal of Molecular Sciences
#25
REVIEW
R Chancel, J Lopez-Castroman, E Baca-Garcia, R Mateos Alvarez, Ph Courtet, I Conejero
PURPOSE OF REVIEW: Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and "Aged, 80 and over". Studies were included if they met the following criteria: (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers...
March 12, 2024: Current Psychiatry Reports
#26
JOURNAL ARTICLE
Brianna Costales, Natalie E Slama, Robert B Penfold, Joshua R Nugent, Scott R Spalding, Stacy A Sterling, Esti Iturralde
OBJECTIVE: This study examined atypical antipsychotic prescribing by FDA approved-use (on-label) status for adolescents before and during the Covid-19 pandemic. METHODS: Retrospective data were collected from electronic health records (EHRs) of adolescents aged 10-17 years in Kaiser Permanente Northern California. New outpatient atypical antipsychotic prescription orders during 2013-2021 were evaluated. Prescriptions were categorized as on-label if linked in EHRs to autism, psychosis, bipolar disorder, or Tourette's diagnoses; otherwise, they were potentially off-label (herein, off-label)...
March 6, 2024: Academic Pediatrics
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JOURNAL ARTICLE
Jeanne Leseur, Charlotte Boiret, Alix Romier, Balthazar Bazin, Louise Basquin, Emilie Stern, Guillaume Pineau, Michel Lejoyeux, Pierre A Geoffroy, Julia Maruani
Currently, there is a major challenge in distinguishing between unipolar and bipolar major depressive episode. A significant body of research has been dedicated to identifying biomarkers that can aid in this differentiation due to its crucial implications, particularly for therapeutic and prognostic purposes. Among the biomarkers of interest, markers related to sleep and circadian rhythms show promise and could potentially aid in making this distinction. Nevertheless, no study has simultaneously examined sleep-wake disorders, circadian rhythms, and seasonal patterns using both subjective and objective measures...
February 20, 2024: Psychiatry Research
#28
JOURNAL ARTICLE
Johanna Heider, Aaron Stahl, Denise Sperlich, Sophia-Marie Hartmann, Sabrina Vogel, Ricarda Breitmeyer, Markus Templin, Hansjürgen Volkmer
BACKGROUND: Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previous studies have mainly used animal models or rather heterogeneous populations of iPSC-derived neurons, generated by undirected differentiation, to study the effects of DISC1 disruption. Since major hypotheses to explain neurodevelopmental, psychiatric disorders rely on altered neuronal connectivity observed in patients, an ideal iPSC-based model requires accurate representation of the structure and complexity of neuronal circuitries...
March 4, 2024: BMC Neuroscience
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JOURNAL ARTICLE
Luana Spano, Cynthia Marie-Claire, Ophélia Godin, Apolline Lebras, Cindie Courtin, Jean-Louis Laplanche, Marion Leboyer, Bruno Aouizerate, Antoine Lefrere, Raoul Belzeaux, Philippe Courtet, Emilie Olié, Caroline Dubertret, Raymund Schwan, Valérie Aubin, Paul Roux, Mircea Polosan, Ludovic Samalin, Emmanuel Haffen, Frank Bellivier, Bruno Etain
Bipolar disorder (BD) has been associated with premature cellular aging with shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals with prematurely shortened TL. The aims of the present study were to replicate this observation in a larger sample and analyze the expression levels of genes associated with age or TL in a subsample of these individuals. TL was measured on peripheral blood DNA using quantitative polymerase chain reaction in a sample of 542 individuals with BD and clustering analyses were performed...
March 1, 2024: Translational Psychiatry
#30
JOURNAL ARTICLE
Qian Xiao, Gui Zhang, Yuan Zhong
BACKGROUND: The symptoms of pediatric bipolar disorder (PBD)-I and PBD-II differ, but accurate identification at an early stage is difficult and may prevent effective treatment of this disorder. Therefore, it is urgent to elucidate a biological marker based on objective imaging indicators to help distinguish the two. Therefore, this research aims to compare the functional connectivity between PBD-I patient and PBD-II patient in different brain networks. METHODS: Our study enrolled 31 PBD-I and 23 PBD-II patients from 12 to 17 years of age...
February 23, 2024: Psychiatry Research. Neuroimaging
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JOURNAL ARTICLE
Tian Li, Ruinan Li, Lei Zhao, Yue Sun, Chuanyue Wang, Qijing Bo
PURPOSE: This cross-sectional study aimed to compare the personality traits of patients with major depressive disorder (MDD) and bipolar disorder (BD) with those of healthy individuals. The goal was to gain insight into the potential impact of personality traits on the development and manifestation of mood disorders. METHODS: One hundred seventy-eight patients with mood disorders were analyzed as either MDD or BD, with each group containing euthymic and depressive members: e-MDD, d-MDD, e-BD, and d-BD...
2024: Neuropsychiatric Disease and Treatment
#32
JOURNAL ARTICLE
Xinyu Li, Jiakuai Yu, Shuo Jiang, Liang Fang, Yifei Li, Shuangshuang Ma, Hui Kong, Ximing Qin, Daomin Zhu
BACKGROUND: Mood disorders are strongly associated with melatonin disturbances. However, it is unclear whether there is a difference in melatonin concentrations and melatonin circadian rhythm profiles between depression and bipolar disorder. In addition, the relationship between anhedonia, a common symptom of affective disorders, and its melatonin circadian rhythm remains under-investigated. METHODS: Thirty-four patients with depression disorder, 20 patients diagnosed with bipolar disorder and 21 healthy controls participated in this study...
February 27, 2024: BMC Psychiatry
#33
Identifying genetic differences between bipolar disorder and major depression through multiple GWAS.
Georgia Panagiotaropoulou, Kajsa-Lotta Georgii Hellberg, Jonathan R I Coleman, Darsol Seok, Janos Kalman, Philip B Mitchell, Peter R Schofield, Andreas J Forstner, Michael Bauer, Laura J Scott, Carlos N Pato, Michele T Pato, Qingqin S Li, George Kirov, Mikael Landén, Lina Jonsson, Bertram Müller-Myhsok, Jordan W Smoller, Elisabeth B Binder, Tanja M Brückl, Darina Czamara, Sandra Van der Auwera, Hans J Grabe, Georg Homuth, Carsten O Schmidt, James B Potash, Raymond J DePaulo, Fernando S Goes, Dean F MacKinnon, Francis M Mondimore, Myrna M Weissman, Jianxin Shi, Mark A Frye, Joanna M Biernacka, Andreas Reif, Stephanie H Witt, René R Kahn, Marco M Boks, Michael J Owen, Katherine Gordon-Smith, Brittany L Mitchell, Nicholas G Martin, Sarah E Medland, Lisa Jones, James A Knowles, Douglas F Levinson, Michael C O'Donovan, Cathryn M Lewis, Gerome Breen, Thomas Werge, Andrew J Schork, Roel Ophoff, Stephan Ripke, Loes Olde Loohuis
BACKGROUND: Accurate diagnosis of bipolar disorder (BD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A key reason is that the first manic episode is often preceded by a depressive one, making it difficult to distinguish BD from unipolar major depressive disorder (MDD). AIMS: Here, we use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores that may aid early differential diagnosis...
January 30, 2024: medRxiv
#34
JOURNAL ARTICLE
Yang Huang, Jingbo Zhang, Kewei He, Xue Mo, Renqiang Yu, Jing Min, Tong Zhu, Yunfeng Ma, Xiangqian He, Fajin Lv, Du Lei, Mengqi Liu
Major depressive disorder (MDD) and bipolar disorder (BD) share clinical features, which complicates their differentiation in clinical settings. This study proposes an innovative approach that integrates structural connectome analysis with machine learning models to discern individuals with MDD from individuals with BD. High-resolution MRI images were obtained from individuals diagnosed with MDD or BD and from HCs. Structural connectomes were constructed to represent the complex interplay of brain regions using advanced graph theory techniques...
February 10, 2024: Diagnostics
#35
JOURNAL ARTICLE
Selena Aranda, Gerard Muntané, Elisabet Vilella
DDR1 has been linked to schizophrenia (SCZ) and bipolar disorder (BD) in association studies. DDR1 encodes 58 distinct transcripts, which can be translated into five isoforms (DDR1a-e) and are expressed in the brain. However, the transcripts expressed in each brain cell type, their functions and their involvement in SCZ and BD remain unknown. Here, to infer the processes in which DDR1 transcripts are involved, we used transcriptomic data from the human brain dorsolateral prefrontal cortex of healthy controls (N = 936) and performed weighted gene coexpression network analysis followed by enrichment analyses...
February 23, 2024: Translational Psychiatry
#36
JOURNAL ARTICLE
Eun Namgung, Eunji Ha, Sujung Yoon, Yumi Song, Hyangwon Lee, Hee-Ju Kang, Jung-Soo Han, Jae-Min Kim, Wonhye Lee, In Kyoon Lyoo, Seog Ju Kim
BACKGROUND: The presence of psychiatric disorders is widely recognized as one of the primary risk factors for suicide. A significant proportion of individuals receiving outpatient psychiatric treatment exhibit varying degrees of suicidal behaviors, which may range from mild suicidal ideations to overt suicide attempts. This study aims to elucidate the transdiagnostic symptom dimensions and associated suicidal features among psychiatric outpatients. METHODS: The study enrolled patients who attended the psychiatry outpatient clinic at a tertiary hospital in South Korea (n = 1, 849, age range = 18-81; 61% women)...
February 17, 2024: Comprehensive Psychiatry
#37
Tanvi Jha, Anil Sharma, Sankar Kalakkunath, Shalini Mullick, Ekta Rahul, Mallika Dixit
Follicular dendritic cell sarcoma (FDCS) is a rare, mesenchymal neoplasm that may be nodal or extranodal in location. Lung involvement is rare. It is a slow-growing, painless tumor with a frequent capacity to recur and metastasize. We present a case of extranodal FDCS of the lung with an unusual presentation. A 34-year-old man presented with the complaints of haemoptysis and chest pain. A large left perihilar mass with endobronchial component was found on radiological evaluation. On endobronchial biopsy and mediastinal tru-cut biopsy, differential diagnoses of an inflammatory myo-fibrohistiocytic lesion and leiomyosarcoma were provided on the basis of morphological features of bipolar spindled cells arranged in intersecting fascicles and storiform patterns and immunophenotyping...
March 2024: Indian Journal of Thoracic and Cardiovascular Surgery
#38
JOURNAL ARTICLE
Shiyi Xiong, Jincan He, Hao Qiu, Cornelis A M van Gestel, ErKai He, Zhengdong Qiao, Liang Cao, Jing Li, Guangquan Chen
Microplastics (MPs) and nanoplastics (NPs) are widely spreading in our living environment, accumulating in the human body and potentially threating human health. The retina, which is a terminally differentiated extension of the central nervous system, is essential for the visual system. However, the effects and molecular mechanisms of MPs/NPs on retina development and function are still unclear. Here, we investigated the effects and modes of action of polystyrene NPs (PS-NPs) on the retina using mice as a mammalian model species...
February 20, 2024: Chemosphere
#39
JOURNAL ARTICLE
Joanna Pawlak, Aleksandra Szczepankiewicz, Maria Skibińska, Beata Narożna, Paweł Kapelski, Przemysław Zakowicz, Karolina Gattner, Dominik Spałek, Łukasz Mech, Monika Dmitrzak-Węglarz
PURPOSE: Bipolar affective disorder (BP) causes major functional impairment and reduced quality of life not only for patients, but also for many close relatives. We aimed to investigate mRNA levels in BP patients to find differentially expressed genes linked to specific clinical course variants; assuming that several gene expression alterations might indicate vulnerability pathways for specific course and severity of the disease. MATERIALS: We searched for up- and down-regulated genes comparing patients with diagnosis of BP type I (BPI) vs type II (BPII), history of suicide attempts, psychotic symptoms, predominance of manic/hypomanic episodes, and history of numerous episodes and comorbidity of substance use disorders or anxiety disorders...
February 17, 2024: Advances in Medical Sciences
#40
JOURNAL ARTICLE
Arsen Arakelyan, Susanna Avagyan, Aleksey Kurnosov, Tigran Mkrtchyan, Gohar Mkrtchyan, Roksana Zakharyan, Karine R Mayilyan, Hans Binder
The molecular events underlying the development, manifestation, and course of schizophrenia, bipolar disorder, and major depressive disorder span from embryonic life to advanced age. However, little is known about the early dynamics of gene expression in these disorders due to their relatively late manifestation. To address this, we conducted a secondary analysis of post-mortem prefrontal cortex datasets using bioinformatics and machine learning techniques to identify differentially expressed gene modules associated with aging and the diseases, determine their time-perturbation points, and assess enrichment with expression quantitative trait loci (eQTL) genes...
February 17, 2024: Schizophrenia (Heidelb)
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