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Bipolar differential

Danella Hafeman, Genna Bebko, Michele A Bertocci, Jay C Fournier, Henry W Chase, Lisa Bonar, Susan B Perlman, Michael Travis, Mary Kay Gill, Vaibhav A Diwadkar, Jeffrey L Sunshine, Scott K Holland, Robert A Kowatch, Boris Birmaher, David Axelson, Sarah M Horwitz, L Eugene Arnold, Mary A Fristad, Thomas W Frazier, Eric A Youngstrom, Robert L Findling, Mary L Phillips
OBJECTIVE: Both bipolar spectrum disorders (BPSD) and attention deficit hyperactivity disorder (ADHD) present with emotion-regulation deficits, but require different clinical management. We examined how the neurobiological underpinnings of emotion regulation might differentiate youth with BPSD versus ADHD (and healthy controls, HCs), specifically assessing functional connectivity (FxC) of amygdala-prefrontal circuitry during an implicit emotion processing task. METHODS: We scanned a subset of the Longitudinal Assessment of Manic Symptoms (LAMS) sample, a clinically recruited cohort with elevated behavioral and emotional dysregulation, and age/sex-ratio matched HCs...
October 11, 2016: Journal of Affective Disorders
Roscoe O Brady, Neeraj Tandon, Grace A Masters, Allison Margolis, Bruce M Cohen, Matcheri Keshavan, Dost Öngür
BACKGROUND: This study aimed to identify how the activity of large-scale brain networks differs between mood states in bipolar disorder. The authors measured spontaneous brain activity in subjects with bipolar disorder in mania and euthymia and compared these states to a healthy comparison population. METHODS: 23 subjects with bipolar disorder type I in a manic episode, 24 euthymic bipolar I subjects, and 23 matched healthy comparison (HC) subjects underwent resting state fMRI scans...
October 6, 2016: Journal of Affective Disorders
Roshan Chudal, Andre Sourander, Heljä-Marja Surcel, Dan Sucksdorff, Susanna Hinkka-Yli-Salomäki, Alan S Brown
OBJECTIVES: C-reactive protein (CRP) is a well-established general marker of inflammation from both infectious and noninfectious exposures. Previous studies have shown that maternal CRP is associated with an increased risk of autism and schizophrenia. The aim of this study was to examine the association between early to mid-gestational serum CRP levels, prospectively assayed in maternal sera, and the risk of bipolar disorder (BPD). METHODS: This study is derived from the Finnish Prenatal Study of Bipolar Disorder (FIPS-B), based on a nested case-control study design...
October 11, 2016: Journal of Affective Disorders
Terry Lee
The diagnosis of bipolar disorder (BD) in youth is confusing and controversial. Controversy notwithstanding, youth diagnosed with BD have high behavioral health needs and are at elevated risk for problematic long-term psychosocial functioning and complex psychiatric medication regimens. Pediatricians and other primary care providers (PCPs) can play an important role in the assessment and treatment of youth diagnosed with BD and the recently created and also controversial diagnosis of disruptive mood dysregulation disorder (DMDD)...
October 1, 2016: Pediatric Annals
Angela H Boal, Daniel J Smith, Linsay McCallum, Scott Muir, Rhian M Touyz, Anna F Dominiczak, Sandosh Padmanabhan
Major depressive and bipolar disorders predispose to atherosclerosis, and there is accruing data from animal model, epidemiological, and genomic studies that commonly used antihypertensive drugs may have a role in the pathogenesis or course of mood disorders. In this study, we propose to determine whether antihypertensive drugs have an impact on mood disorders through the analysis of patients on monotherapy with different classes of antihypertensive drugs from a large hospital database of 525 046 patients with follow-up for 5 years...
November 2016: Hypertension
Boyin Liu, Torsten Bossing
We removed single identified neurons from living Drosophila embryos to gain insight into the transcriptional control of developing neuronal networks. The microarray analysis of the transcriptome of two sibling neurons revealed seven differentially expressed transcripts between both neurons (threshold: log21.4). One transcript encodes the RNA splicing factor B52. Loss of B52 increases growth of axon branches. B52 function is also required for Choline acetyltransferase (ChAT ) splicing. At the end of embryogenesis, loss of B52 function impedes splicing of ChAT, reduces acetylcholine synthesis, and extends the period of uncoordinated muscle twitches during larval hatching...
October 11, 2016: Scientific Reports
Merel M Schreuder, Christiaan H Vinkers, Esther Mesman, Stephan Claes, Willem A Nolen, Manon H J Hillegers
Children of a parent with bipolar disorder (bipolar offspring) have an increased risk for mood disorders. While genetic factors play a significant role in this population, susceptibility to environmental stress may also significantly contribute to this vulnerability for mood disorders. Childhood trauma has consistently been found to increase the risk for mood disorders, with persisting consequences for hypothalamic-pituitary-adrenal (HPA) axis functionality. However, it is currently unknown whether childhood trauma specifically affects HPA axis activity in individuals with a familial risk for bipolar disorder...
September 24, 2016: Psychoneuroendocrinology
E S Gouvea, V K Ota, C Noto, M L Santoro, L M Spindola, P N Moretti, C M Carvalho, G Xavier, A C Rios, J R Sato, M A F Hayashi, E Brietzke, A Gadelha, R A Bressan, Q Cordeiro, S I Belangero
Psychotic disorders affect ~3% of the general population and are among the most severe forms of mental diseases. In early stages of psychosis, clinical aspects may be difficult to distinguish from one another. Undifferentiated psychopathology at the first-episode of psychosis (FEP) highlights the need for biomarkers that can improve and refine differential diagnosis. We investigated gene expression differences between patients with FEP-schizophrenia spectrum (SCZ; N=53) or FEP-Mania (BD; N=16) and healthy controls (N=73)...
October 4, 2016: Translational Psychiatry
Mavi Deniz Ozel, Mehmet Emin Onder, Ali Sazci
The transcription factor 4 (TCF4) gene encodes a helix-loop-helix transcription factor protein, which initiates neuronal differentiation and is primarily expressed during nervous system development. The aim of the present study is to investigate the association of the TCF4 rs9960767 polymorphism and bipolar disorder, which is highly heritable. DNA isolation was performed on 95 patients with bipolar disorder and 108 healthy control subjects to examine the TCF4 rs9960767 polymorphism. Genotypic and allelic frequencies were determined using the polymerase chain reaction-restriction fragment length polymorphism method designed in our laboratory...
October 2016: Biomedical Reports
Jing Hu, Jinyuan Xu, Lin Pang, Hongying Zhao, Feng Li, Yulan Deng, Ling Liu, Yujia Lan, Xinxin Zhang, Tingting Zhao, Chaohan Xu, Chun Xu, Yun Xiao, Xia Li
Schizophrenia (SZ) and bipolar disorder (BD) are severe neuropsychiatric disorders with serious impact on patients, together termed "major psychosis". Recently, long intergenic non-coding RNAs (lincRNAs) were reported to play important roles in mental diseases. However, little was known about their molecular mechanism in pathogenesis of SZ and BD. Here, we performed RNA sequencing on 82 post-mortem brain tissues from three brain regions (orbitofrontal cortex (BA11), anterior cingulate cortex (BA24) and dorsolateral prefrontal cortex (BA9)) of patients with SZ and BD and control subjects, generating over one billion reads...
September 19, 2016: Oncotarget
Luz H Ospina, Manuela Russo, George M Nitzburg, Armando Cuesta-Diaz, Megan Shanahan, Mercedes M Perez-Rodriguez, Meaghan Mcgrath, Hannah Levine, Sandra Mulaimovic, Katherine E Burdick
OBJECTIVES: Several studies have documented the prevalence and effects of cigarette smoking on cognition in psychotic disorders; fewer have focused on bipolar disorder (BD). Cognitive and social dysfunction are common in BD, and the severity of these deficits may be related both to illness features (e.g., current symptoms, psychosis history) and health-related behaviors (e.g., smoking, alcohol use). The current study assessed the influence of cigarette smoking on general and social cognition in a BD cohort, accounting for illness features with a focus on psychosis history...
September 21, 2016: Bipolar Disorders
Sy-Jye Leu, Yi-Yuan Yang, Hsing-Cheng Liu, Chieh-Yu Cheng, Yu-Chen Wu, Ming-Chyi Huang, Yuen-Lun Lee, Chi-Ching Chen, Winston W Shen, Ko-Jiunn Liu
Valproic acid (VPA), with inhibition activity mainly towards histone deacetylase (HDAC) and Glycogen Synthase Kinase (GSK)-3, and lithium, with inhibition activity mainly toward GSK-3, are both prescribed in clinical as mood-stabilizers and anticonvulsants for the control of bipolar disorder. This study aims to compare the immuno-modulation activities of VPA and lithium, especially on the differentiation and functions of dendritic cells (DC). Our data show that treatment with VPA or lithium effectively alleviated the severity of collagen-induced arthritis triggered by LPS in mice...
September 17, 2016: Journal of Cellular Physiology
Douglas Gunzler, Martha Sajatovic, Richard McCormick, Adam Perzynski, Charles Thomas, Stephanie Kanuch, Kristin A Cassidy, Edna Fuentes-Casiano, Neal Dawson
OBJECTIVE: Care for people with serious mental illness and diabetes is complicated by clinical heterogeneity. This cross-sectional analysis of 200 individuals with comorbid serious mental illness and diabetes explored differentiation between patient subgroups that were characterized on the basis of selected dimensions within a biopsychosocial framework. METHODS: Relationships between self-efficacy, treatment expectation, social support, and depression were first assessed via bivariate Spearman correlations among 200 individuals participating in a randomized controlled trial who had diabetes along with major depression, bipolar disorder, or schizophrenia...
September 15, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
Kukju Kweon, Hyun-Jeong Lee, Kee Jeong Park, Yeonho Joo, Hyo-Won Kim
OBJECTIVE: We aimed to evaluate the Child Behavior Checklist (CBCL) profiles in youths with bipolar and depressive disorders. METHODS: Seventy-four subjects with a mean age of 14.9±1.6years (36 boys) with mood disorders and their parents were recruited from September 2011 to June 2013 in the Department of Psychiatry, Asan Medical Center, Seoul, Korea. Diagnosis of mood disorder and comorbid psychiatric disorder was confirmed by child psychiatrists using the Schedule for Affective Disorders and Schizophrenia for School Age Children - Present and Lifetime version (K-SADS-PL)...
October 2016: Comprehensive Psychiatry
Sophia Frangou, Danai Dima, Jigar Jogia
Improved clinical care for Bipolar Disorder (BD) relies on the identification of diagnostic markers that can reliably detect disease-related signals in clinically heterogeneous populations. At the very least, diagnostic markers should be able to differentiate patients with BD from healthy individuals and from individuals at familial risk for BD who either remain well or develop other psychopathology, most commonly Major Depressive Disorder (MDD). These issues are particularly pertinent to the development of translational applications of neuroimaging as they represent challenges for which clinical observation alone is insufficient...
September 10, 2016: NeuroImage
Guoqing Zhao, Chen Zhang, Jun Chen, Yousong Su, Rubai Zhou, Fan Wang, Weiping Xia, Jia Huang, Zuowei Wang, Yingyan Hu, Lan Cao, Xiaoyun Guo, Chengmei Yuan, Yong Wang, Zhenghui Yi, Weihong Lu, Yan Wu, Zhiguo Wu, Wu Hong, Daihui Peng, Yiru Fang
There is a high rate of misdiagnosis between major depressive disorder (MDD) and bipolar disorder (BD) in clinical practice. Our previous work provided suggestive evidence for brain-derived neurotrophic factor (BDNF) in differentiating BD from MDD. In this study, we aimed to investigate the role of mature BDNF (mBDNF) and its precursor (proBDNF) in distinguishing bipolar depression (BP) from MDD during acute depressive episode. A total of 105 participants, including 44 healthy controls, 37 MDD patients and 24 BP patients, were recruited...
September 9, 2016: Molecular Neurobiology
P A Vöhringer, S A Barroilhet, K Alvear, S Medina, C Espinosa, K Alexandrovich, P Riumallo, F Leiva, M E Hurtado, J Cabrera, M Sullivan, N Holtzman, S N Ghaemi
OBJECTIVE: The differential diagnosis of bipolar illness vs. borderline personality is controversial. Both conditions manifest impulsive behavior, unstable interpersonal relationships, and mood symptoms. This study examines whether and which mood clinical features can differentiate between both conditions. METHOD: A total of 260 patients (mean ± standard deviation age 41 ± 13 years, 68% female) attending to a mood clinic were examined for diagnosis of bipolar illness and borderline personality disorder using SCID-I, SCID-II, and clinical mood criteria extracted from Mood Disorder Questionnaire (MDQ)...
September 9, 2016: Acta Psychiatrica Scandinavica
Zhong Sheng, Yun Wang, Weiqian Zhao, Lirong Qiu, Yingbin Sun
Based on the optical arrangement of a bipolar differential confocal microscopy (BDCM), laser differential fitting confocal microscopy (DFCM) is proposed in this paper using the feature of BDCM that a zero-crossing point (ZCP) of the axial response curve precisely corresponds to the focus of the system objective. A linear segment of the DFCM axial response around the ZCP is used to fit a straight line. Focus can be determined by solving the equations of the fitting lines, and then, the sample surface could be measured and reconstructed with a high resolution...
September 1, 2016: Applied Optics
Peter M Thompson, Dianne A Cruz, Elizabeth A Fucich, Dianna Y Olukotun, Masami Takahashi, Makoto Itakura
SNAP-25 is a neurotransmitter vesicular docking protein which has been associated with brain disorders such as attention deficit hyperactivity disorder, bipolar disorder and schizophrenia. In this project, we were interested if clinical factors are associated with differential SNAP-25 expression. We examined the SNAP-25 isoform mRNA and protein levels in postmortem cortex Brodmann's area 9 (BA9) and BA24 (n = 29). Subjects were divided by psychiatric diagnosis, clinical variables including mood state in the last week of life and lifetime impulsiveness...
December 2015: Molecular Neuropsychiatry
Ling Z Morgan, Brandi Rollins, Adolfo Sequeira, William Byerley, Lynn E DeLisi, Alan F Schatzberg, Jack D Barchas, Richard M Myers, Stanley J Watson, Huda Akil, William E Bunney, Marquis P Vawter
Genome-wide association studies of schizophrenia encompassing the major histocompatibility locus (MHC) were highly significant following genome-wide correction. This broad region implicates many genes including the MHC complex class II. Within this interval we examined the expression of two MHC II genes (HLA-DPA1 and HLA-DRB1) in brain from individual subjects with schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and controls by differential gene expression methods. A third MHC II mRNA, CD74, was studied outside of the MHC II locus, as it interacts within the same immune complex...
2016: Microarrays
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