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Bipolar differential

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https://www.readbyqxmd.com/read/29759822/multivariate-relationships-between-cognition-and-brain-anatomy-across-the-psychosis-spectrum
#1
Amanda L Rodrigue, Jennifer E McDowell, Neeraj Tandon, Matcheri S Keshavan, Carol A Tamminga, Godfrey D Pearlson, John A Sweeney, Robert D Gibbons, Brett A Clementz
BACKGROUND: Cognitive and structural brain abnormalities range from mild to severe in psychosis. The relation of specific cognitive functions to specific brain structures across the psychosis spectrum is less certain. METHODS: Participants (n = 678) with bipolar, schizoaffective, or schizophrenia psychoses and healthy control subjects were recruited via the Bipolar-Schizophrenia Network for Intermediate Phenotypes. The Schizo-Bipolar Scale was used to create a psychosis continuum (from purely affective to purely nonaffective)...
March 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29747500/reversible-negative-resistive-switching-in-an-individual-fe-al2o3-hybrid-nanotube-for-nonvolatile-memory
#2
Yalong Ye, Jie Zhao, Li Xiao, Baochang Cheng, Yanhe Xiao, Shuijin Lei
Hybrid nanostructures can show enormous potential in different areas due to their unique structural configurations. Herein, Fe@Al2O3 hybrid nanotubes are constructed via a homogeneous coprecipitation method followed by subsequent annealing at reducing atmosphere. The introduction of zero bandgap Fe nanocrystals in the wall of ultrawide bandgap Al2O3 insulator nanotubes results in the formation of charge trap centers, and correspondingly a single hybrid nanotube-based two-terminal device can show reversible negative resistive switching (RS) characteristics with symmetrical negative differential resistance (NDR) at relatively high operation bias voltages...
May 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29745862/novel-functional-variants-at-the-gwas-implicated-loci-might-confer-risk-to-major-depressive-disorder-bipolar-affective-disorder-and-schizophrenia
#3
Leonid O Bryzgalov, Elena E Korbolina, Ilja I Brusentsov, Elena Y Leberfarb, Natalia P Bondar, Tatiana I Merkulova
BACKGROUND: A challenge of understanding the mechanisms underlying cognition including neurodevelopmental and neuropsychiatric disorders is mainly given by the potential severity of cognitive disorders for the quality of life and their prevalence. However, the field has been focused predominantly on protein coding variation until recently. Given the importance of tightly controlled gene expression for normal brain function, the goal of the study was to assess the functional variation including non-coding variation in human genome that is likely to play an important role in cognitive functions...
April 19, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29739866/region-specific-regulation-of-presynaptic-dopamine-homeostasis-by-d2-autoreceptors-shapes-the-in-vivo-impact-of-the-neuropsychiatric-disease-associated-dat-variant-val559
#4
Raajaram Gowrishankar, Paul J Gresch, Gwynne L Davis, Rania M Katamish, Justin R Riele, Adele M Stewart, Roxanne A Vaughan, Maureen K Hahn, Randy D Blakely
Disruptions of dopamine (DA) signaling contribute to a broad spectrum of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), addiction, bipolar disorder and schizophrenia. Despite evidence that risk for these disorders derives from heritable variation in DA-linked genes, a better understanding is needed of the molecular and circuit context through which gene variation drives distinct disease traits. Previously, we identified the DA transporter (DAT) variant Val559 in subjects with ADHD and established that the mutation supports anomalous DAT-mediated DA efflux (ADE)...
May 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29737181/comparative-familial-aggregation-of-bipolar-disorder-in-patients-with-bipolar-i-and-bipolar-ii-disorders
#5
Gordon B Parker, Mia Romano, Rebecca K Graham, Tahlia Ricciardi
OBJECTIVE: We sought to quantify the prevalence and differential prevalence of a bipolar disorder among family members of patients with a bipolar I or II disorder. METHODS: The sample comprised 1165 bipolar and 1041 unipolar patients, with the former then sub-typed as having either a bipolar I or II condition. Family history data was obtained via an online self-report tool. RESULTS: Prevalence of a family member having a bipolar disorder (of either sub-type) was distinctive (36...
May 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29734096/does-recent-mania-affect-response-to-antidepressants-in-bipolar-disorder-a-re-analysis-of-step-bd-data
#6
Zahra Mousavi, Sheri Johnson, Descartes Li
BACKGROUND: One previous study suggested that the presence of a manic episode before bipolar depression is related to worse response to antidepressants. METHOD: To examine this effect in a larger sample, we used data from the large, multi-site STEP-BD study. We hypothesized that among persons treated with antidepressants for bipolar depression, manic or mixed episodes before depression onset (as compared to euthymia) would predict lower rate of recovery, more sustained depressive symptoms and higher rate of switching into mania/hypomania after antidepressant treatment of bipolar depression...
April 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29734005/complexity-analysis-of-spontaneous-brain-activity-in-mood-disorders-a-magnetoencephalography-study-of-bipolar-disorder-and-major-depression
#7
Alberto Fernández, Ali H Al-Timemy, Francisco Ferre, Gabriel Rubio, Javier Escudero
BACKGROUND AND PURPOSE: The lack of a biomarker for Bipolar Disorder (BD) causes problems in the differential diagnosis with other mood disorders such as major depression (MD), and misdiagnosis frequently occurs. Bearing this in mind, we investigated non-linear magnetoencephalography (MEG) patterns in BD and MD. METHODS: Lempel-Ziv Complexity (LZC) was used to evaluate the resting-state MEG activity in a cross-sectional sample of 60 subjects, including 20 patients with MD, 16 patients with BD type-I, and 24 control (CON) subjects...
April 26, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29723656/white-matter-microstructure-alterations-correlate-with-terminally-differentiated-cd8-effector-t-cell-depletion-in-the-peripheral-blood-in-mania-combined-dti-and-immunological-investigation-in-the-different-phases-of-bipolar-disorder
#8
Paola Magioncalda, Matteo Martino, Samuele Tardito, Bruno Sterlini, Benedetta Conio, Valentina Marozzi, Giulia Adavastro, Laura Capobianco, Daniel Russo, Alessia Parodi, Francesca Kalli, Giorgia Nasi, Tiziana Altosole, Niccolò Piaggio, Georg Northoff, Daniela Fenoglio, Matilde Inglese, Gilberto Filaci, Mario Amore
BACKGROUND: White matter (WM) microstructural abnormalities and, independently, signs of immunological activation were consistently demonstrated in bipolar disorder (BD). However, the relationship between WM and immunological alterations as well as their occurrence in the various phases of BD remain unclear. METHOD: In 60 type I BD patients - 20 in manic, 20 in depressive, 20 in euthymic phases - and 20 controls we investigated: (i) diffusion tensor imaging (DTI)-derived fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD) using a tract-based spatial statistics (TBSS) approach; (ii) circulating T cell subpopulations frequencies, as well as plasma levels of different cytokines; (iii) potential relationships between WM and immunological data...
April 30, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29721110/use-of-microelectrode-near-field-signals-to-determine-catheter-contact
#9
Mathew R Levy, Faisal M Merchant, Jonathan J Langberg, David B Delurgio
Background: The utility of standard distal bipolar electrograms (sEGMs) for assessing catheter-tissue contact may be obscured by the presence of far-field signals. Microelectrode electrograms (mEGMs) may overcome this limitation. Methods: We compared 5 mEGM characteristics (amplitude, frequency content, temporal signal variability, presence of injury current, and amplitude differential between bipoles) with the sEGM for determining tissue contact in 20 patients undergoing ablation of typical atrial flutter...
February 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29717657/bone-marrow-cd133-stem-cells-ameliorate-visual-dysfunction-in-streptozotocin-induced-diabetic-mice-with-early-diabetic-retinopathy
#10
Liyuan Rong, Xianliang Gu, Jing Xie, Yuxiao Zeng, Qiyou Li, Siyu Chen, Ting Zou, Langyue Xue, Haiwei Xu, Zheng Qin Yin
Diabetic retinopathy (DR), one of the leading causes of vision loss worldwide, is characterized by neurovascular disorders. Emerging evidence has demonstrated retinal neurodegeneration in the early pathogenesis of DR, and no treatment has been developed to prevent the early neurodegenerative changes that precede detectable microvascular disorders. Bone marrow CD133+ stem cells with revascularization properties exhibit neuroregenerative potential. However, whether CD133+ cells can ameliorate the neurodegeneration at the early stage of DR remains unclear...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29704413/difficulties-to-differentiate-mood-disorders-co-occurring-with-compulsive-gambling-discussion-based-on-a-case-study
#11
REVIEW
Anna Pilszyk, Andrzej Silczuk, Bogusław Habrat, Janusz Heitzman
Contemporary literature does not take a clear position on the issue of determining civil and criminal liability of persons diagnosed with pathological gambling, and all the more so in case of possible comorbidity of or interference with other mental disorders. Diagnostic difficulties are demonstrated by a clinical picture of a patient with problem gambling who underwent forensic and psychiatric assessments to evaluate the process of making informed (and independent) decisions in view of numerous concluded civil law (mainly financial) agreements...
February 28, 2018: Psychiatria Polska
https://www.readbyqxmd.com/read/29702176/bipolar-affective-disorder-and-borderline-personality-disorder-differentiation-based-on-the-history-of-early-life-stress-and-psychoneuroendocrine-measures
#12
Angela Kaline Mazer, Anthony J Cleare, Allan H Young, Mario F Juruena
INTRODUCTION: Borderline Personality Disorder (BPD) and Bipolar Affective Disorder (BD) have clinical characteristics in common which often make their differential diagnosis difficult. The history of early life stress (ELS) may be a differentiating factor between BPD and BD, as well as its association with clinical manifestations and specific neuroendocrine responses in each of these diagnoses. OBJECTIVE: Assessing and comparing patients with BD and BPD for factors related to symptomatology, etiopathogenesis and neuroendocrine markers...
April 24, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29691917/an-immunological-age-index-in-bipolar-disorder-a-confirmatory-factor-analysis-of-putative-immunosenescence-markers-and-associations-with-clinical-characteristics
#13
Lucas B Rizzo, Walter Swardfager, Pawan Kumar Maurya, Maiara Zeni Graiff, Mariana Pedrini, Elson Asevedo, Ana Cláudia Cassinelli, Moisés E Bauer, Quirino Cordeiro, Jan Scott, Elisa Brietzke, Hugo Cogo-Moreira
OBJECTIVES: The study aims to generate an immunological age (IA) trait on the basis of immune cell differentiation parameters, and to test whether the IA is related to age and disease characteristics. METHODS: Forty-four euthymic type I bipolar disorder patients were included in this study. Five immunosenescence-related parameters were assessed: proportions of late-differentiated cells (e.g., CD3+CD8+CD28-CD27- and CD3-CD19+IgD-CD27-), and the expression of CD69, CD71, and CD152 after stimulation...
April 25, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29689499/is-subthreshold-bipolar-ii-disorder-more-difficult-to-differentiate-from-borderline-personality-disorder-than-formal-bipolar-ii-disorder
#14
Adam Bayes, Rebecca K Graham, Gordon B Parker, Stacey McCraw
Recent research indicates that borderline personality disorder (BPD) can be diagnostically differentiated from the bipolar disorders. However, no studies have attempted to differentiate participants with sub-threshold bipolar disorder or SubT BP (where hypomanic episodes last less than 4 days) from those with a BPD. In this study, participants were assigned a SubT BP, bipolar II disorder (BP II) or BPD diagnosis based on clinical assessment and DSM-IV criteria. Participants completed self-report measures and undertook a clinical interview which collected socio-demographic information, a mood history, family history, developmental history, treatment information, and assessed cognitive, emotional and behavioural functioning...
April 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29685287/the-circulating-levels-of-cd4-t-helper-cells-are-higher-in-bipolar-disorder-as-compared-to-major-depressive-disorder
#15
Karlijn Becking, Bartholomeus C M Haarman, Laura Grosse, Willem A Nolen, Stephan Claes, Volker Arolt, Robert A Schoevers, Hemmo A Drexhage
INTRODUCTION: Clinical differentiation between bipolar disorder (BD) and major depressive disorder (MDD) is difficult. Research has therefore focused on discriminatory biological markers. Previous studies in MDD reported T cell deficits, while the limited studies in BD reported T cell activation. Studies directly comparing circulating numbers of T cells and T cell subsets between BD and MDD are lacking. The studies in the MOODINFLAME consortium make such a comparison possible. METHODS: The number of circulating leukocyte populations (lymphocytes, monocytes, NK cells, B cells, T cells, CD3+CD8+ T cytotoxic cells, CD3+CD4+ T helper cells, Th1, Th2, Th17 and T regulatory cells) was determined using FACS technology in a cohort of 83 euthymic BD patients, 8 BD patients with a current mood episode and 165 healthy controls (HC)...
June 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29681025/major-differences-in-neurooxidative-and-neuronitrosative-stress-pathways-between-major-depressive-disorder-and-types-i-and-ii-bipolar-disorder
#16
Michael Maes, Kamila Landucci Bonifacio, Nayara Rampazzo Morelli, Heber Odebrecht Vargas, Décio Sabbatini Barbosa, André F Carvalho, Sandra Odebrecht Vargas Nunes
Accumulating evidence indicates that oxidative and nitrosative stress (O&NS) pathways play a key role in the pathophysiology of bipolar disorder (BD) and major depressive disorder (MDD). However, only a handful of studies have directly compared alterations in O&NS pathways among patients with MDD and BD types I (BPI) and BPII. Thus, the current study compared superoxide dismutase (SOD1), lipid hydroperoxides (LOOH), catalase, nitric oxide metabolites (NOx), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) between mood disorder patients in a clinically remitted state...
April 21, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29669557/discovery-biology-of-neuropsychiatric-syndromes-dbns-a-center-for-integrating-clinical-medicine-and-basic-science
#17
Biju Viswanath, Naren P Rao, Janardhanan C Narayanaswamy, Palanimuthu T Sivakumar, Arun Kandasamy, Muralidharan Kesavan, Urvakhsh Meherwan Mehta, Ganesan Venkatasubramanian, John P John, Odity Mukherjee, Meera Purushottam, Ramakrishnan Kannan, Bhupesh Mehta, Thennarasu Kandavel, B Binukumar, Jitender Saini, Deepak Jayarajan, A Shyamsundar, Sydney Moirangthem, K G Vijay Kumar, Jagadisha Thirthalli, Prabha S Chandra, Bangalore N Gangadhar, Pratima Murthy, Mitradas M Panicker, Upinder S Bhalla, Sumantra Chattarji, Vivek Benegal, Mathew Varghese, Janardhan Y C Reddy, Padinjat Raghu, Mahendra Rao, Sanjeev Jain
BACKGROUND: There is emerging evidence that there are shared genetic, environmental and developmental risk factors in psychiatry, that cut across traditional diagnostic boundaries. With this background, the Discovery biology of neuropsychiatric syndromes (DBNS) proposes to recruit patients from five different syndromes (schizophrenia, bipolar disorder, obsessive compulsive disorder, Alzheimer's dementia and substance use disorders), identify those with multiple affected relatives, and invite these families to participate in this study...
April 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29666833/resolving-the-coffey-paradox-what-does-the-androgen-receptor-do-in-normal-vs-malignant-prostate-epithelial-cells
#18
REVIEW
John T Isaacs
Donald Straley Coffey completed his 85 year life's journey on November 9, 2017. In his wake, he left a legion of inspired and loyal students, fellows, and faculty colleagues from all over the world to carry on his passion both for life in general and his 50 year quest to conquer cancer. Early in his career, Dr. Coffey developed a series of animal models to study how androgen regulates the growth of both normal and abnormal prostatic epithelium. As part of these early studies, Dr. Coffey uncovered a paradox in that anti-androgen treatment given at the "wrong" time paradoxically enhanced, not inhibited, normal prostate growth...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29643331/electroencephalographic-delta-alpha-frequency-activity-differentiates-psychotic-disorders-a-study-of-schizophrenia-bipolar-disorder-and-methamphetamine-induced-psychotic-disorder
#19
REVIEW
Fleur M Howells, Hendrik S Temmingh, Jennifer H Hsieh, Andrea V van Dijen, David S Baldwin, Dan J Stein
Electroencephalography (EEG) has been proposed as a neurophysiological biomarker to delineate psychotic disorders. It is known that increased delta and decreased alpha, which are apparent in psychosis, are indicative of inappropriate arousal state, which leads to reduced ability to attend to relevant information. On this premise, we investigated delta/alpha frequency activity, as this ratio of frequency activity may serve as an effective neurophysiological biomarker. The current study investigated differences in delta/alpha frequency activity, in schizophrenia (SCZ), bipolar I disorder with psychotic features and methamphetamine-induced psychosis...
April 12, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29621482/large-scale-crispr-mediated-somatic-mutagenesis-identifies-a-signaling-pathway-that-guides-retinal-development
#20
Olga Minkina, Claude Desplan
As the mammalian outer retina develops, rod and cone photoreceptors synapse with their respective bipolar cells. Sarin et al. (2018) develop a somatic CRISPR technique to determine how genes differentially expressed among the four cell types mediate outer retina development.
April 4, 2018: Neuron
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