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https://www.readbyqxmd.com/read/28099138/role-of-glial-cell-line-derived-neurotrophic-factor-in-the-pathogenesis-and-treatment-of-mood-disorders
#1
Anton S Tsybko, Tatiana V Ilchibaeva, Nina K Popova
Glial cell line-derived neurotrophic factor (GDNF) is widely recognized as a survival factor for dopaminergic neurons, but GDNF has also been shown to promote development, differentiation, and protection of other central nervous system neurons and was thought to play an important role in various neuropsychiatric disorders. Severe mood disorders, such as primarily major depressive disorder and bipolar affective disorder, attract particular attention. These psychopathologies are characterized by structural alterations accompanied by the dysregulation of neuroprotective and neurotrophic signaling mechanisms required for the maturation, growth, and survival of neurons and glia...
January 18, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28095742/lithium-response-in-bipolar-disorders-and-core-clock-genes-expression
#2
Pierre A Geoffroy, Emmanuel Curis, Cindie Courtin, Jeverson Moreira, Thomas Morvillers, Bruno Etain, Jean-Louis Laplanche, Frank Bellivier, Cynthia Marie-Claire
OBJECTIVES: We examine if the lithium response is associated with changes in core clock genes expressions. METHODS: The effect of a therapeutic concentration of lithium (1mM) on the expression levels of 17 circadian genes, was examined in lymphoblastoid cell lines (LCLs) derived from two well-characterized groups of BD patients, defined as lithium non-responders (NR, n = 20) or excellent responders (ER, n = 16). Quantitative real-time PCR (qRT-PCR) were conducted at 2, 4 and 8 days (d2, d4, d8) with and without lithium exposure...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28093821/decreasing-rates-of-pediatric-bipolar-within-an-outpatient-practice
#3
Daniel Wesemann
PROBLEM: Pediatric bipolar disorder (PBD) prevalence is estimated to be 1-3%. Nationally and internationally, rates of PBD have increased by over 400%. However, in Iowa and at one psychiatric clinic in Iowa, from 2008-2013, there was a decrease in PBD diagnosis of 33 and 51.2% respectively. This study examined the diagnosing practices of PBD by local providers in one outpatient mental health center. METHOD: Parents completed a screening packet to differentiate between PBD and attention deficit hyperactivity disorder (ADHD) using three tools: Child Mania Rating Scale (CMRS), Child Behavior Checklist-Mania Scale (CBCL-MS), and the NICHQ Vanderbilt...
January 16, 2017: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/28093238/a-model-of-the-mitochondrial-basis-of-bipolar-disorder
#4
REVIEW
Gerwyn Morris, Ken Walder, Sean L McGee, Olivia M Dean, Susannah J Tye, Michael Maes, Michael Berk
BACKGROUND: Bipolar disorder phenomenologically is a biphasic disorder of energy availability; increased in mania and decreased in depression. In consort, there is accumulating evidence indicating increased mitochondrial respiration and ATP production in bipolar mania which contrasts with decreased mitochondrial function in patients in the euthymic or depressive phase of the illness. Consequently, the central thesis of this paper is that bipolar disorder is due to a phasic dysregulation of mitochondrial biogenergetics...
January 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28070258/a-scientific-correlation-between-dystemprament-in-unani-medicine-and-diseases-a-systematic-review
#5
REVIEW
Sepideh Miraj, Sara Kiani
BACKGROUND: Temperament or mezaj refers to four different humors differentiating in individuals and, as a result, proposes specific therapy for their diseases. OBJECTIVE: The aim of this study was to overview the scientific correlation between temperaments in Unani medicine and diseases. METHODS: This study was carried out from March 2015 to February 2016. A computerized search of published articles was performed using PubMed, Google Scholar, Scopus and Web of Science, and Medline databases as well as local and regional resources between 1983 and 2014...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28063207/lithiumeter-version-2-0
#6
Gin S Malhi, Samuel Gershon, Tim Outhred
BACKGROUND: The Lithiumeter was developed as a visual and practical guide for determining lithium levels in the management of bipolar disorder (BD). It appears to have been well received, as evidenced by its increasing popularity amongst doctors as a deskside clinical aide, and adoption and reproduction of the schematic in clinical guidelines and texts. However, since its publication 5 years ago, key basic neuroscience and clinical research developments pertaining to lithium have significantly advanced our understanding, necessitating further refinement of guidance concerning the practicalities of lithium therapy...
December 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/28051268/immunoregulatory-effect-of-neuronal-like-cells-in-inducting-differentiation-of-bone-marrow-mesenchymal-stem-cells
#7
J Xu, H Lu, Z-N Miao, W-J Wu, Y -Z Jiang, F Ge, W-F Fang, A-H Zhu, G Chen, J-H Zhou, Y-Z Lu, Z-F Tang, Y Wang
OBJECTIVE: To evaluate the immune activity of bone marrow mesenchymal stem cells (BMSCs), and explore the biological characteristics and capabilities of BMSCs and the potential to be differentiated into neuronal cells in vitro. MATERIALS AND METHODS: The BMSCs were isolated and proliferated in vitro to generate the xenogeneic mixed lymphocyte reaction. Moreover, peripheral BMSCs (pBMSCs) were added according to different ratios, which methods were stated as follows: 1: Dulbecco's Modified Eagle Medium (DMEM) + 10% Fetal Bovine Serum (FBS) + 1 μmol/L all-trans-retinoic acid (ATRA) + 20 μg/L basic fibroblast growth factor (bFGF) + 20 μg/L epidermal growth factor (EGF); 2: DMEM + 2% dimethyl sulfoxide (DMSO) + 100 μmol/L butylated hydroxyanisole (BHA)...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28049086/structural-and-metabolic-differentiation-between-bipolar-disorder-with-psychosis-and-substance-induced-psychosis-an-integrated-mri-pet-study
#8
A C Altamura, G Delvecchio, G Marotta, L Oldani, A Pigoni, V Ciappolino, E Caletti, C Rovera, C Dobrea, C Arici, B Benatti, G Camuri, C Prunas, R A Paoli, B Dell'osso, C Cinnante, F M Triulzi, P Brambilla
BACKGROUND: Bipolar disorder (BD) may be characterized by the presence of psychotic symptoms and comorbid substance abuse. In this context, structural and metabolic dysfunctions have been reported in both BD with psychosis and addiction, separately. In this study, we aimed at identifying neural substrates differentiating psychotic BD, with or without substance abuse, versus substance-induced psychosis (SIP) by coupling, for the first time, magnetic resonance imaging (MRI) and positron emission tomography (PET)...
December 30, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28045094/building-a-genetic-risk-model-for-bipolar-disorder-from-genome-wide-association-data-with-random-forest-algorithm
#9
Li-Chung Chuang, Po-Hsiu Kuo
A genetic risk score could be beneficial in assisting clinical diagnosis for complex diseases with high heritability. With large-scale genome-wide association (GWA) data, the current study constructed a genetic risk model with a machine learning approach for bipolar disorder (BPD). The GWA dataset of BPD from the Genetic Association Information Network was used as the training data for model construction, and the Systematic Treatment Enhancement Program (STEP) GWA data were used as the validation dataset. A random forest algorithm was applied for pre-filtered markers, and variable importance indices were assessed...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28040657/neuropsychological-profiles-of-major-depressive-disorder-and-bipolar-disorder-during-euthymia-a-systematic-literature-review-of-comparative-studies
#10
REVIEW
Alejandro G Szmulewicz, Marina P Valerio, José M Smith, Cecilia Samamé, Diego J Martino, Sergio A Strejilevich
Bipolar disorder and major depressive disorder have been shown to be associated with neurocognitive abnormalities during periods of clinical remission. However, at present, there is no consensus on whether these disorders have distinctive cognitive profiles. The aim of this study was to provide an updated systematic review of studies comparing neuropsychological functioning between bipolar disorder and major depressive disorder during remission. Main findings included the following: 1) no differences regarding performances in measures of attention and processing speed, executive functions and theory of mind were found between both patient groups and 2) regarding verbal memory, preliminary evidence points towards a more defective performance in patients with bipolar disorder than those with major depressive disorder...
December 24, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28039552/cerebrospinal-fluid-microglia-and-neurodegenerative-markers-in-twins-concordant-and-discordant-for-psychotic-disorders
#11
Viktoria Johansson, Joel Jakobsson, Rebecca G Fortgang, Henrik Zetterberg, Kaj Blennow, Tyrone D Cannon, Christina M Hultman, Lennart Wetterberg, Mikael Landén
Schizophrenia and bipolar disorder are debilitating psychiatric disorders with partially shared symptomatology including psychotic symptoms and cognitive impairment. Aberrant levels of microglia and neurodegenerative cerebrospinal fluid (CSF) markers have previously been found in schizophrenia and bipolar disorder. We aimed to analyze familial and environmental influences on these CSF markers and their relation to psychiatric symptoms and cognitive ability. CSF was collected from 17 complete twin pairs, nine monozygotic and eight dizygotic, and from one twin sibling...
December 30, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28038685/grafted-c-kit-ssea1-eye-wall-progenitor-cells-delay-retinal-degeneration-in-mice-by-regulating-neural-plasticity-and-forming-new-graft-to-host-synapses
#12
Xi Chen, Zehua Chen, Zhengya Li, Chen Zhao, Yuxiao Zeng, Ting Zou, Caiyun Fu, Xiaoli Liu, Haiwei Xu, Zheng Qin Yin
BACKGROUND: Despite diverse pathogenesis, the common pathological change observed in age-related macular degeneration and in most hereditary retinal degeneration (RD) diseases is photoreceptor loss. Photoreceptor replacement by cell transplantation may be a feasible treatment for RD. The major obstacles to clinical translation of stem cell-based cell therapy in RD remain the difficulty of obtaining sufficient quantities of appropriate and safe donor cells and the poor integration of grafted stem cell-derived photoreceptors into the remaining retinal circuitry...
December 30, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28035686/interaction-between-atypical-antipsychotics-and-the-gut-microbiome-in-a-bipolar-disease-cohort
#13
Stephanie A Flowers, Simon J Evans, Kristen M Ward, Melvin G McInnis, Vicki L Ellingrod
OBJECTIVES: The atypical antipsychotic (AAP) class is often associated with metabolic disease, but the mechanistic underpinnings of this risk are not understood. Due to reports linking gut bacteria function to metabolic disease, we hypothesize that AAP-treatment in adults results in gut dysbiosis potentiating metabolic criteria. This report describes recent findings linking AAP-treatment with differences in gut microbiota communities in a human cohort with bipolar disorder (BD). METHODS: In a cross- sectional design, we obtained 16S ribosomal sequences from 117 BD patients (49 AAP-treated, 68 non-AAP treated)...
December 30, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/28029428/the-serotonin-transporter-gene-5-httlpr-polymorphism-is-associated-with-affective-psychoses-but-not-with-schizophrenia-a-large-scale-study-in-the-russian-population
#14
Vera Golimbet, Galina Korovaitseva, Tatyana Lezheiko, L I Abramova, V G Kaleda
BACKGROUND: Affective syndrome is thought to be a key feature that differentiates schizophrenia from schizoaffective disorder (SA) and bipolar disorder with psychotic features (BDP). However genetic underpinnings of these differences remain unresolved. OBJECTIVES: We compared clinical variables of affective psychoses (SA, BDP and schizophrenia with affective symptoms (AFF SCZ)) and schizophrenia without affective symptoms (non-AFF SCZ) and searched for a genetic variant that may differentiate affective psychosis from non-AFF SCZ...
October 26, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28025071/th17-cells-correlate-positively-to-the-structural-and-functional-integrity-of-the-brain-in-bipolar-depression-and-healthy-controls
#15
Sara Poletti, Harm de Wit, Elena Mazza, Annemarie J M Wijkhuijs, Clara Locatelli, Veronica Aggio, Cristina Colombo, Francesco Benedetti, Hemmo A Drexhage
: Abnormalities of T cell-mediated immune activation, in the absence of active somatic immune diseases, have consistently been reported in mood disorders. Apart from being important players in the regulation of cells of the immune system, T cells are essential for normal brain development. We here report studies on the relationship between circulating levels of T helper cells and structural and functional brain imaging in depressed bipolar patients. Since the CCL20-CCR6 axis is an important entry to the brain we differentiated the various T helper cell subpopulations on the basis of their chemokine receptor expression...
December 23, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28011626/meningeal-retinoic-acid-contributes-to-neocortical-lamination-and-radial-migration-during-mouse-brain-development
#16
Carole Haushalter, Brigitte Schuhbaur, Pascal Dollé, Muriel Rhinn
Retinoic acid (RA) is a diffusible molecule involved in early forebrain patterning. Its later production in the meninges by the retinaldehyde dehydrogenase RALDH2 coincides with the time of cortical neuron generation. A function of RA in this process has not been adressed directly as Raldh2(-/-) mouse mutants are embryonic lethal. Here we used a conditional genetic strategy to inactivate Raldh2 just prior to its onset of expression in the developing meninges. This inactivation does not affect the formation of the cortical progenitor populations, their rate of division, or timing of differentiation...
December 23, 2016: Biology Open
https://www.readbyqxmd.com/read/28008851/functional-dichotomy-and-distinct-nanoscale-assemblies-of-a-cell-cycle-controlled-bipolar-zinc-finger-regulator
#17
Johann Mignolet, Seamus Holden, Matthieu Bergé, Gaël Panis, Ezgi Eroglu, Laurence Théraulaz, Suliana Manley, Patrick H Viollier
Protein polarization underlies differentiation in metazoans and in bacteria. How symmetric polarization can instate functional asymmetry remains elusive. Here, we show by super-resolution photo-activated localization microscopy and edgetic mutations that the bitopic zinc-finger protein ZitP implements specialized developmental functions - pilus biogenesis and multifactorial swarming motility - while shaping distinct nanoscale (bi)polar architectures in the asymmetric model bacterium Caulobacter crescentus. Polar assemblage and accumulation of ZitP and its effector protein CpaM are orchestrated in time and space by conserved components of the cell cycle circuitry that coordinate polar morphogenesis with cell cycle progression, and also act on the master cell cycle regulator CtrA...
December 23, 2016: ELife
https://www.readbyqxmd.com/read/27999805/efficiency-of-human-epiphyseal-chondrocytes-with-differential-replication-numbers-for-cellular-therapy-products
#18
Michiyo Nasu, Shinichiro Takayama, Akihiro Umezawa
The cell-based therapy for cartilage or bone requires a large number of cells; serial passages of chondrocytes are, therefore, needed. However, fates of expanded chondrocytes from extra fingers remain unclarified. The chondrocytes from human epiphyses morphologically changed from small polygonal cells to bipolar elongated spindle cells and to large polygonal cells with degeneration at early passages. Gene of type II collagen was expressed in the cells only at a primary culture (Passage 0) and Passage 1 (P1) cells...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27997229/incidence-of-mental-health-diagnoses-in-veterans-of-operations-iraqi-freedom-enduring-freedom-and-new-dawn-2001-2014
#19
Christine Ramsey, James Dziura, Amy C Justice, Hamada Hamid Altalib, Harini Bathulapalli, Matthew Burg, Suzanne Decker, Mary Driscoll, Joseph Goulet, Sally Haskell, Joseph Kulas, Karen H Wang, Kristen Mattocks, Cynthia Brandt
OBJECTIVES: To evaluate gender, age, and race/ethnicity as predictors of incident mental health diagnoses among Operations Iraqi Freedom, Enduring Freedom, and New Dawn veterans. METHODS: We used US Veterans Health Administration (VHA) electronic health records from 2001 to 2014 to examine incidence rates and sociodemographic risk factors for mental health diagnoses among 888 142 veterans. RESULTS: Posttraumatic stress disorder (PTSD) was the most frequently diagnosed mental health condition across gender and age groups...
February 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27992854/differential-associations-of-affective-temperaments-and-diagnosis-of-major-affective-disorders-with-suicidal-behavior
#20
Ross J Baldessarini, Marco Innamorati, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi, Maurizio Pompili
BACKGROUND: Affective temperaments are associated with suicidal risk, but their predictive value relative to diagnosis of major affective disorder is uncertain. METHODS: We compared diagnoses, affective-temperament ratings (TEMPS-A), and other potential risk factors in 956 psychiatric inpatients, using bivariate analyses and multivariable logistic regression modeling for associations with suicidal status. RESULTS: Lifetime suicide-attempt rates were high (43...
December 13, 2016: Journal of Affective Disorders
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