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Bipolar differential

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https://www.readbyqxmd.com/read/29145062/differentiating-multiple-vs-single-lifetime-suicide-attempters-with-bipolar-disorders-a-retrospective-study
#1
Chiara Arici, Laura Cremaschi, Cristina Dobrea, Matteo Vismara, Benedetta Grancini, Beatrice Benatti, Massimiliano Buoli, Shefali Miller, Terence A Ketter, A Carlo Altamura, Bernardo Dell'Osso
BACKGROUND: The risk of suicide in Bipolar Disorder (BD) has been estimated up to 20-30 times higher compared with the general population. Previous suicide attempts (SAs) represent a well-established risk factor for further attempts and for death by suicide in patients with psychiatric disorders. However, little is known about the socio-demographic and clinical profile of BD patients with a history of multiple SAs (MSAs). The present study sought to characterize BD patients with MSAs versus single suicide attempt (SSA) within a large Italian sample...
October 19, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29141073/forces-of-tool-tissue-interaction-to-assess-surgical-skill-level
#2
Taku Sugiyama, Sanju Lama, Liu Shi Gan, Yaser Maddahi, Kourosh Zareinia, Garnette R Sutherland
Importance: The application of optimal forces between surgical instruments and tissue is fundamental to surgical performance and learning. To date, this force has not been measured clinically during the performance of microsurgery. Objectives: To establish a normative catalog of force profiles during the performance of surgery, to compare force variables among surgeons with different skill levels, and to evaluate whether such a force-based metric determines or differentiates skill level...
November 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29139167/the-zinc-finger-gene-nolz1-regulates-the-formation-of-retinal-progenitor-cells-and-suppresses-the-lim3-lhx3-phenotype-of-retinal-bipolar-cells-in-chicken-retina
#3
Maria K E Blixt, Dardan Konjusha, Henrik Ring, Finn Hallböök
BACKGROUND: The zinc-finger transcription factor Nolz1 regulates spinal cord neuron development by interacting with the transcription factors Isl1, Lim1 and Lim3, which are also important for photoreceptors, horizontal and bipolar cells during retinal development. We therefore studied Nolz1 during retinal development. RESULTS: Nolz1 expression was seen in two waves during development: one early (peak at embryonic day 3-4.5) in retinal progenitors and one late (embryonic day 8) in newly differentiated cells in the inner nuclear layer...
November 15, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29137925/polycomb-repression-complex-2-is-required-for-the-maintenance-of-retinal-progenitor-cells-and-balanced-retinal-differentiation
#4
Naoko Fujimura, Andrea Kuzelova, Anja Ebert, Hynek Strnad, Jitka Lachova, Ondrej Machon, Meinrad Busslinger, Zbynek Kozmik
Polycomb repressive complexes maintain transcriptional repression of genes encoding crucial developmental regulators through chromatin modification. Here we investigated the role of Polycomb repressive complex 2 (PRC2) in retinal development by inactivating its key components Eed and Ezh2. Conditional deletion of Ezh2 resulted in a partial loss of PRC2 function and accelerated differentiation of Müller glial cells. In contrast, inactivation of Eed led to the ablation of PRC2 function at early postnatal stage...
November 11, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29116664/unraveling-the-biology-of-bipolar-disorder-using-induced-pluripotent-stem-derived-neurons
#5
REVIEW
Nathaniel D Miller, John R Kelsoe
OBJECTIVES: Bipolar disorder has been studied from numerous angles, from pathological studies to large-scale genomic studies, overall making moderate gains toward an understanding of the disorder. With the advancement of induced pluripotent stem (iPS) cell technology, in vitro models based on patient samples are now available that inherently incorporate the complex genetic variants that largely are the basis for this disorder. A number of groups are starting to apply iPS technology to the study of bipolar disorder...
November 8, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29109536/self-patterning-of-rostral-caudal-neuroectoderm-requires-dual-role-of-fgf-signaling-for-localized-wnt-antagonism
#6
Nozomu Takata, Eriko Sakakura, Mototsugu Eiraku, Takeya Kasukawa, Yoshiki Sasai
The neuroectoderm is patterned along a rostral-caudal axis in response to localized factors in the embryo, but exactly how these factors act as positional information for this patterning is not yet fully understood. Here, using the self-organizing properties of mouse embryonic stem cell (ESC), we report that ESC-derived neuroectoderm self-generates a Six3(+) rostral and a Irx3(+) caudal bipolarized patterning. In this instance, localized Fgf signaling performs dual roles, as it regulates Six3(+) rostral polarization at an earlier stage and promotes Wnt signaling at a later stage...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29107522/-silent-nmda-synapses-enhance-motion-sensitivity-in-a-mature-retinal-circuit
#7
Santhosh Sethuramanujam, Xiaoyang Yao, Geoff deRosenroll, Kevin L Briggman, Greg D Field, Gautam B Awatramani
Retinal direction-selective ganglion cells (DSGCs) have the remarkable ability to encode motion over a wide range of contrasts, relying on well-coordinated excitation and inhibition (E/I). E/I is orchestrated by a diverse set of glutamatergic bipolar cells that drive DSGCs directly, as well as indirectly through feedforward GABAergic/cholinergic signals mediated by starburst amacrine cells. Determining how direction-selective responses are generated across varied stimulus conditions requires understanding how glutamate, acetylcholine, and GABA signals are precisely coordinated...
October 25, 2017: Neuron
https://www.readbyqxmd.com/read/29106556/location-matters-distinct-dna-methylation-patterns-in-gabaergic-interneuronal-populations-from-separate-microcircuits-within-the-human-hippocampus
#8
W Brad Ruzicka, Sivan Subburaju, Joseph T Coyle, Francine M Benes
Recent studies describe distinct DNA methylomes among phenotypic subclasses of neurons in the human brain, but variation in DNA methylation between common neuronal phenotypes distinguished by their function within distinct neural circuits remains an unexplored concept. Studies able to resolve epigenetic profiles at the level of microcircuits are needed to illuminate chromatin dynamics in the regulation of specific neuronal populations and circuits mediating normal and abnormal behaviors.The Illumina HumanMethylation450 BeadChip was used to assess genome-wide DNA methylation in stratum oriens GABAergic interneurons sampled by laser-microdissection from two discrete microcircuits along the trisynaptic pathway in postmortem human hippocampus from eight control, eight schizophrenia, and eight bipolar disorder subjects...
November 2, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29105664/brain-behavior-participant-similarity-networks-among-youth-and-emerging-adults-with-schizophrenia-spectrum-autism-spectrum-or-bipolar-disorder-and-matched-controls
#9
Laura Stefanik, Lauren Erdman, Stephanie H Ameis, George Foussias, Benoit H Mulsant, Tina Behdinan, Anna Goldenberg, Lauren J O'Donnell, Aristotle N Voineskos
There is considerable heterogeneity in social cognitive and neurocognitive performance among people with schizophrenia spectrum disorders (SSD), autism spectrum disorders (ASD), bipolar disorder (BD), and healthy individuals. This study used Similarity Network Fusion (SNF), a novel data-driven approach, to identify participant similarity networks based on relationships among demographic, brain imaging, and behavioral data. T1-weighted and diffusion-weighted magnetic resonance images were obtained for 174 adolescents and young adults (aged 16-35 years) with an SSD (n=51), an ASD without intellectual disability (n=38), euthymic BD (n=34), and healthy controls (n=51)...
November 6, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29102835/the-differential-association-between-history-of-childhood-sexual-abuse-and-body-mass-index-in-early-and-late-stages-of-bipolar-disorder
#10
Emilie Leclerc, Rodrigo B Mansur, Rodrigo Grassi-Oliveira, Quirino Cordeiro, Flavio Kapczinski, Roger S McIntyre, Elisa Brietzke
BACKGROUND: History of distal stressors such as childhood trauma is a well-established, non-specific vulnerability factor for multiple mental illnesses. The objective of this study was to investigate the possible association between history of childhood trauma and body mass index (BMI) in individuals in early and late stages of bipolar disorder (BD) and to verify is there was any difference in the association of sexual abuse history and obesity in early versus late stages of BD. METHODS: Seventy-one euthymic BD-type I patients and eighty-one healthy controls were evaluated using the Childhood Trauma Questionnaire (CTQ) and body mass index (BMI)...
October 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29102659/regulation-of-inflammatory-pathways-in-schizophrenia-a-comparative-study-with-bipolar-disorder-and-healthy-controls
#11
L García-Álvarez, J R Caso, M P García-Portilla, L de la Fuente-Tomás, L González-Blanco, P Sáiz Martínez, J C Leza, J Bobes
BACKGROUND: Immune-inflammatory processes have been implicated in schizophrenia (SCH), but their specificity is not clear. MAIN AIM: To identify potential differential intra-/intercellular biochemical pathways controlling immune-inflammatory response and their oxidative-nitrosative impact on SCH patients, compared with bipolar disorder (BD) patients and healthy controls (HC). METHODS: Cross-sectional, naturalistic study of a cohort of SCH patients (n=123) and their controls [BD (n=102) and HC (n=80)]...
October 18, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29101589/the-behavioral-approach-system-bas-model-of-vulnerability-to-bipolar-disorder-evidence-of-a-continuum-in-bas-sensitivity-across-adolescence
#12
Richard T Liu, Taylor A Burke, Lyn Y Abramson, Lauren B Alloy
Behavioral Approach System (BAS) sensitivity has been implicated in the development of a variety of different psychiatric disorders. Prominent among these in the empirical literature are bipolar spectrum disorders (BSDs). Given that adolescence represents a critical developmental stage of risk for the onset of BSDs, it is important to clarify the latent structure of BAS sensitivity in this period of development. A statistical approach especially well-suited for delineating the latent structure of BAS sensitivity is taxometric analysis, which is designed to evaluate whether the latent structure of a construct is taxonic (i...
November 4, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29073747/psychometric-properties-of-the-hypomania-checklist-32-in-korean-patients-with-mood-disorders
#13
Bo-Hyun Yoon, Jules Angst, Won-Myong Bahk, Hee Ryung Wang, Seung-Oh Bae, Moon-Doo Kim, Young-Eun Jung, Kyung Joon Min, Hwang-Bin Lee, Seunghee Won, Jeongwan Hong, Myong Su Choi, Duk-In Jon, Young Sup Woo
Objective: The aim of this study was to examine the validity of the Korean version of the Hypomania Checklist-32, second revision (HCL-32-R2) in mood disorder patients. Methods: A total of 454 patients who diagnosed as mood disorder according to Structured Clinical Interview for DSM-IV Axis I Disorders, clinician version (SCID-CV) (bipolar disorder [BD] I, n=190; BD-II, n=72; and major depressive disorder [MDD], n=192) completed the Korean module of the HCL-32-R2 (KHCL-32-R2)...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29071714/dner-and-nfia-are-expressed-by-developing-and-mature-aii-amacrine-cells-in-the-mouse-retina
#14
Patrick W Keeley, Benjamin E Reese
The present study has taken advantage of publicly available cell type specific mRNA expression databases in order to identify potential genes participating in the development of retinal AII amacrine cells. We profile two such genes, Delta/Notch-like EGF repeat containing (Dner) and nuclear factor I/A (Nfia), that are each heavily expressed in AII amacrine cells in the mature mouse retina, and which conjointly identify this retinal cell population in its entirety when using antibodies to DNER and NFIA. DNER is present on the plasma membrane, while NFIA is confined to the nucleus, consistent with known functions of each of these two proteins...
October 26, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29067888/lithium-induced-gene-expression-alterations-in-two-peripheral-cell-models-of-bipolar-disorder
#15
Sarah Kittel-Schneider, Max Hilscher, Claus-Jürgen Scholz, Heike Weber, Lena Grünewald, Ricarda Schwarz, Andreas G Chiocchetti, Andreas Reif
OBJECTIVES: The aim of our study was to investigate molecular mechanisms of lithium action by studying the gene expression profile of peripheral cell models generated from bipolar patients (BD) and healthy controls (HC). METHODS: EBV-immortalized lymphoblastoid cells (LCLs) and fibroblast cells from BD and HC were incubated with either lithiumchloride or plain medium for 3 weeks. We first conducted a microarray gene expression study. The most promising differentially regulated genes in terms of lithium-associated or disorder-associated pathways were then replicated by quantitative Real Time PCR (qRT PCR)...
October 25, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29029678/positive-and-negative-affect-as-links-between-social-anxiety-and-depression-predicting-concurrent-and-prospective-mood-symptoms-in-unipolar-and-bipolar-mood-disorders
#16
Jonah N Cohen, M Taylor Dryman, Amanda S Morrison, Kirsten E Gilbert, Richard G Heimberg, June Gruber
The co-occurrence of social anxiety and depression is associated with increased functional impairment and a more severe course of illness. Social anxiety disorder is unique among the anxiety disorders in sharing an affective profile with depression, characterized by low levels of positive affect (PA) and high levels of negative affect (NA). Yet it remains unclear how this shared affective profile contributes to the covariation of social anxiety and depressive symptoms. We examined whether self-reported PA and NA accounted for unique variance in the association between social anxiety and depressive symptoms across three groups (individuals with remitted bipolar disorder, type I [BD; n = 32], individuals with remitted major depressive disorder [MDD; n = 31], and nonpsychiatric controls [n = 30]) at baseline and follow-ups of 6 and 12 months...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29017764/dna-methylation-and-antipsychotic-treatment-mechanisms-in-schizophrenia-progress-and-future-directions
#17
REVIEW
Ellen S Ovenden, Nathaniel W McGregor, Robin A Emsley, Louise Warnich
Antipsychotic response in schizophrenia is a complex, multifactorial trait influenced by pharmacogenetic factors. With genetic studies thus far providing little biological insight or clinical utility, the field of pharmacoepigenomics has emerged to tackle the so-called "missing heritability" of drug response in disease. Research on psychiatric disorders has only recently started to assess the link between epigenetic alterations and treatment outcomes. DNA methylation, the best characterised epigenetic mechanism to date, is discussed here in the context of schizophrenia and antipsychotic treatment outcomes...
October 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28993200/pax6-is-essential-for-the-generation-of-late-born-retinal-neurons-and-for-inhibition-of-photoreceptor-fate-during-late-stages-of-retinogenesis
#18
Liv Aleen Remez, Akishi Onishi, Yotam Menuchin-Lasowski, Assaf Biran, Seth Blackshaw, Karl J Wahlin, Donlad J Zack, Ruth Ashery-Padan
In the developing retina, as in other regions of the CNS, neural progenitors give rise to individual cell types during discrete temporal windows. Pax6 is expressed in retinal progenitor cells (RPCs) throughout the course of retinogenesis, and has been shown to be required during early retinogenesis for generation of most early-born cell types. In this study, we examined the function of Pax6 in postnatal mouse retinal development. We found that Pax6 is essential for the generation of late-born interneurons, while inhibiting photoreceptor differentiation...
October 7, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28981913/olfactory-functioning-in-first-episode-psychosis
#19
Vidyulata Kamath, Patricia Lasutschinkow, Koko Ishizuka, Akira Sawa
BACKGROUND: Though olfactory deficits are well-documented in schizophrenia, fewer studies have examined olfactory performance profiles across the psychosis spectrum. The current study examined odor identification, discrimination, and detection threshold performance in first-episode psychosis (FEP) patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depression with psychotic features, and other psychotic conditions. METHOD: FEP patients (n = 97) and healthy adults (n = 98) completed birhinal assessments of odor identification, discrimination, and detection threshold sensitivity for lyral and citralva...
August 31, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28976732/atomic-monolayer-two-dimensional-lateral-quasi-heterojunction-bipolar-transistors-with-resonant-tunneling-phenomenon
#20
Che-Yu Lin, Xiaodan Zhu, Shin-Hung Tsai, Shiao-Po Tsai, Sidong Lei, Ming-Yang Li, Yumeng Shi, Lain-Jong Li, Shyh-Jer Huang, Wen-Fa Wu, Wen-Kuan Yeh, Yan-Kuin Su, Kang L Wang, Yann-Wen Lan
High-frequency operation with ultra-thin, lightweight and extremely flexible semiconducting electronics are highly desirable for the development of mobile devices, wearable electronic systems and defense technologies. In this work, the first experimental observation of quasi-heterojunction bipolar transistors utilizing a monolayer of the lateral WSe2-MoS2 junctions as the conducting p-n channel is demonstrated. Both lateral n-p-n and p-n-p heterojunction bipolar transistors are fabricated to exhibit the output characteristics and current gain...
October 4, 2017: ACS Nano
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