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https://www.readbyqxmd.com/read/27830449/understanding-early-age-of-onset-a-review-of-the-last-5%C3%A2-years
#1
REVIEW
Gabrielle A Carlson, Caroly Pataki
The age at onset of bipolar disorder ranging from childhood to adolescent to adult has significant implications for frequency, severity and duration of mood episodes, comorbid psychopathology, heritability, response to treatment, and opportunity for early intervention. There is increasing evidence that recognition of prodromal symptoms in at-risk populations and mood type at onset are important variables in understanding the course of this illness in youth. Very early childhood onset of symptoms including anxiety/depression, mood lability, and subthreshold manic symptoms, along with family history of a parent with early onset bipolar disorder, appears to predict the highest risk of early onset disorder with the most severe course...
December 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27806866/neurofunctional-differences-among-youth-with-and-at-varying-risk-for-developing-mania
#2
Jeffrey A Welge, Lawrence J Saliba, Jeffrey R Strawn, James C Eliassen, L Rodrigo Patino, Caleb M Adler, Wade Weber, Marguerite Reid Schneider, Drew H Barzman, Stephen M Strakowski, Melissa P DelBello, Robert K McNamara
OBJECTIVE: To examine prefrontal and amygdala activation during emotional processing in youth with or at varying risk for developing mania to identify candidate central prodromal risk biomarkers. METHOD: Four groups of medication-free adolescents (10-20 years old) participated: adolescents with first-episode bipolar I disorder (BP-I; n = 32), adolescents with a parent with bipolar disorder and a depressive disorder (at-risk depressed [ARD]; n = 32), healthy adolescents with a parent with bipolar disorder (at-risk healthy [ARH]; n = 32), and healthy adolescents with no personal or family history of psychiatric illness (healthy comparison [HC]; n = 32)...
November 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27802240/bipolar-disorder-and-frontotemporal-dementia-an-intriguing-association
#3
Apostolos Papazacharias, Madia Lozupone, Maria Rosaria Barulli, Rosa Capozzo, Bruno P Imbimbo, Federica Veneziani, Roberto De Blasi, Marcello Nardini, Davide Seripa, Francesco Panza, Giancarlo Logroscino
Bipolar disorder (BD) could represent a prodromal state of frontotemporal dementia (FTD). Two patients affected by lifelong BD with a progressive decline of cognitive functions, behavioral, and neurological signs, reached the early diagnosis of FTD before the age of 60. They were diagnosed as affected by primary progressive aphasia and FTD with parkinsonism, respectively. A diagnosis of FTD should therefore be taken into account, in case of unexpected cognitive and behavioral decline in patients with a long history of BD...
October 11, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27737475/pharmacotherapy-in-children-and-adolescents-at-clinical-high-risk-for-psychosis-and-bipolar-disorder
#4
M Lambert, V Niehaus, C Correll
This review aims to describe the importance of i) detecting individuals at clinical high-risk for psychosis (schizophrenia) or bipolar disorder, especially in children and adolescents, in order to enable early intervention, and ii) evaluating different intervention strategies, especially pharmacotherapy, during the subsyndromal or "prodromal" stages of these severe and often debilitating disorders. The different approaches regarding the psychotic and bipolar clinical high-risk state are discussed, including reasons and evidence for early (pharmacological) intervention and risks of treatment vs...
October 13, 2016: Pharmacopsychiatry
https://www.readbyqxmd.com/read/27522263/characterizing-psychosis-risk-traits-in-africa-a-longitudinal-study-of-kenyan-adolescents
#5
Daniel Mamah, Abednego Musau, Victoria N Mutiso, Akinkunle Owoso, Arbi Ben Abdallah, Linda B Cottler, Catherine W Striley, Elaine F Walker, David M Ndetei
The schizophrenia prodrome has not been extensively studied in Africa. Identification of prodromal behavioral symptoms holds promise for early intervention and prevention of disorder onset. Our goal was to investigate schizophrenia risk traits in Kenyan adolescents and identify predictors of psychosis progression. 135 high-risk (HR) and 142 low-risk (LR) adolescents were identified from among secondary school students in Machakos, Kenya, using the structured interview of psychosis-risk syndromes (SIPS) and the Washington early recognition center affectivity and psychosis (WERCAP) screen...
October 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27488129/parental-reports-of-prodromal-psychopathology-in-pediatric-bipolar-disorder
#6
Mariely Hernandez, Ciro Marangoni, Marie C Grant, Jezelle Estrada, Gianni L Faedda
OBJECTIVES: Objectives: Early psychopathology in children diagnosed with Bipolar Disorder (BD) remains poorly characterized. Parental retrospective reports provide helpful details on the earliest manifestations and their evolution over time. These symptoms occur early in the course of BD, often before a formal diagnosis is made and/or treatment is implemented, and are of great importance to early recognition and prevention. METHODS: Parents of pre-pubertal children and adolescents with DSM-IV diagnoses of BD attending an outpatient mood disorders clinic provided retrospective ratings of 37 symptoms of child psychopathology...
August 1, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27344625/affective-disorders-as-potential-complication-of-anti-acne-treatment-with-isotretinoin-a-case-series
#7
Karakula-Juchnowicz Hanna, Kowal-Popczak Agnieszka, Dzikowski Michal, Juchnowicz Dariusz, Dzikowska Izabela, Makarewicz Agata, Dubas-Slemp Halina
OBJECTIVE: To analyse cases of 9 patients (18-27 yo) who were consequently admitted to our department and treated with affective disorders (AD) while undergoing isotretinoin (INN) therapy. METHODS: A semi-structured questionnaire designed by the authors was used to analyse many variables related to demographic characteristics, dermatologic and psychiatrics symptoms, AD course and treatment, family history of mental disorders, building on medical histories of patients and their families, and available medical records...
November 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27343882/the-bipolar-prodrome-meta-analysis-of-symptom-prevalence-prior-to-initial-or-recurrent-mood-episodes
#8
REVIEW
Anna R Van Meter, Coty Burke, Eric A Youngstrom, Gianni L Faedda, Christoph U Correll
OBJECTIVE: The aim of this study was to meta-analyze the prevalence of symptoms before an initial mood episode of bipolar disorder (BD) and the prevalence of subthreshold symptoms before a BD mood episode recurrence, to facilitate early identification and prevention. METHOD: Systematic literature reviews were conducted in PsycINFO and PubMed for prospective or retrospective studies reporting on the prevalence and longest duration of symptoms before an initial or recurrent mood episode of BD...
July 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27310243/do-the-trajectories-of-bipolar-disorder-and-schizophrenia-follow-a-universal-staging-model
#9
Anne Duffy, Gin S Malhi, Paul Grof
OBJECTIVE: The purpose of this study is to address the question of whether a universal staging model of severe psychiatric disorders is a viable direction for future research by examining the extant literature. METHOD: A narrative review was conducted of the relevant historical, conceptual, and empirical literature pertaining to the clinical trajectory of bipolar disorder and schizophrenia and issues relevant to staging. RESULTS: There is substantive evidence that classic recurrent bipolar disorder is separable from schizophrenia on the basis of family history, developmental and clinical course, treatment response, and neurobiological findings...
May 4, 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27267294/depression-with-melancholic-features-is-associated-with-higher-long-term-risk-for-dementia
#10
Frederico Simões do Couto, Nuno Lunet, Sandra Ginó, Catarina Chester, Vanda Freitas, Carolina Maruta, Maria Luísa Figueira, Alexandre de Mendonça
BACKGROUND: Depression has been reported to increase the risk of subsequently developing dementia, but the nature of this relation remains to be elucidated. Depression can be a prodrome/manifestation of dementia or an early risk factor, and the effect may differ according to depression subtypes. Our aim was to study the association between early-onset depression and different depression subtypes, and the later occurrence of dementia. METHODS: We conducted a cohort study including 322 subjects with depression, recruited between 1977 and 1984...
September 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27161263/-stress-and-psychotic-transition-a-literature-review
#11
B Chaumette, O Kebir, C Mam Lam Fook, J Bourgin, B P Godsil, R Gaillard, T M Jay, M-O Krebs
BACKGROUND: Psychiatric disorders are consistent with the gene x environment model, and non-specific environmental factors such as childhood trauma, urbanity, and migration have been implicated. All of these factors have in common to dysregulate the biological pathways involved in response to stress. Stress is a well-known precipitating factor implicated in psychiatric disorders such as depression, bipolar disorder, anxiety, and possibly schizophrenia. More precisely, psychosocial stress induces dysregulation of the hypothalamic-pituitary-adrenal axis (HPA) and could modify neurotransmission, which raises the question of the involvement of stress-related biological changes in psychotic disorders...
August 2016: L'Encéphale
https://www.readbyqxmd.com/read/27114621/subjective-symptoms-in-euthymic-bipolar-disorder-and-remitted-schizophrenia-patients-a-comparative-study
#12
Manish Kumar, Vinod Kumar Sinha, Anwesha Mondal
BACKGROUND: Subjective experience means subtle, not yet psychotic abnormalities of experience that might be present during remitted phase and also in prodromal phase of schizophrenia and might be accurately efficient in identifying individuals at risk of eminent psychosis (Parnas et al., 2003). Apart from schizophrenic patients, bipolar patients also experience certain subjective symptoms in their euthymic state. They often experience subtle cognitive impairment and functional disturbances during their euthymic states...
March 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27066819/association-between-childhood-dimensions-of-attention-deficit-hyperactivity-disorder-and-adulthood-clinical-severity-of-bipolar-disorders
#13
Bruno Etain, M Lajnef, J Loftus, C Henry, A Raust, S Gard, J P Kahn, M Leboyer, J Scott, F Bellivier
BACKGROUND: Clinical features of attention deficit hyperactivity disorder can be frequently observed in cases with bipolar disorders and associated with greater severity of bipolar disorders. Although designed as a screening tool for attention deficit hyperactivity disorder, the Wender Utah Rating Scale could, given its factorial structure, be useful in investigating the early history of impulsive, inattentive or mood-related symptoms among patients with bipolar disorders. METHODS: We rated the Wender Utah Rating Scale in 276 adult bipolar disorder cases and 228 healthy controls and tested its factorial structure and any associations with bipolar disorder phenomenology...
April 11, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/26893233/is-there-a-bipolar-prodrome-among-children-and-adolescents
#14
Jeffrey Hunt, Charlotte M Schwarz, Paul Nye, Elisabeth Frazier
Bipolar disorder in youth substantially impairs behavior, family, and social functioning and interferes with developmental course. There is increasing interest in defining a bipolar prodrome similar to that reported in early-onset psychosis that will allow for earlier intervention and reduction in overall morbidity and mortality. Several lines of research have addressed this important issue including studies of offspring of bipolar parents, high-risk cohorts, and longitudinal follow-up of subjects with major depressive disorder (MDD), ADHD, and bipolar spectrum disorder...
April 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/26892940/toward-the-definition-of-a-bipolar-prodrome-dimensional-predictors-of-bipolar-spectrum-disorders-in-at-risk-youths
#15
Danella M Hafeman, John Merranko, David Axelson, Benjamin I Goldstein, Tina Goldstein, Kelly Monk, Mary Beth Hickey, Dara Sakolsky, Rasim Diler, Satish Iyengar, David Brent, David Kupfer, Boris Birmaher
OBJECTIVE: The authors sought to assess dimensional symptomatic predictors of new-onset bipolar spectrum disorders in youths at familial risk of bipolar disorder ("at-risk" youths). METHOD: Offspring 6-18 years old of parents with bipolar I or II disorder (N=359) and community comparison offspring (N=220) were recruited. At baseline, 8.4% of the offspring of bipolar parents had a bipolar spectrum disorder. Over 8 years, 14.7% of offspring for whom follow-up data were available (44/299) developed a new-onset bipolar spectrum disorder (15 with bipolar I or II disorder)...
July 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/26692432/early-stages-of-bipolar-disorder-characterization-and-strategies-for-early-intervention
#16
REVIEW
Adiel C Rios, Mariane N Noto, Lucas B Rizzo, Rodrigo Mansur, Flávio E Martins, Rodrigo Grassi-Oliveira, Christoph U Correll, Elisa Brietzke
OBJECTIVE: To characterize the early stages of bipolar disorder (BD), defined as the clinical prodrome/subsyndromal stage and first-episode phase, and strategies for their respective treatment. METHODS: A selective literature search of the PubMed, Embase, PsycINFO, and ISI databases from inception until March 2014 was performed. Included in this review were articles that a) characterized prodromal and first-episode stages of BD or b) detailed efficacy and safety/tolerability of interventions in patients considered prodromal for BD or those with only one episode of mania/hypomania...
October 2015: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/26692427/clinical-characteristics-and-influence-of-childhood-trauma-on-the-prodrome-of-bipolar-disorder
#17
Mariane N Noto, Cristiano Noto, André C Caribé, Ângela Miranda-Scippa, Sandra O Nunes, Ana C Chaves, Denise Amino, Rodrigo Grassi-Oliveira, Christoph U Correll, Elisa Brietzke
OBJECTIVES: To describe the onset pattern, frequency, and severity of the signs and symptoms of the prodrome of the first hypomanic/manic episode and first depressive episode of bipolar disorder (BD) and to investigate the influence of a history of childhood maltreatment on the expression of prodromal symptoms. METHODS: Using a semi-structured interview, the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R), information regarding prodromal symptoms was assessed from patients with a DSM-IV diagnosis of BD...
October 2015: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/26671170/adolescents-and-adults-at-clinical-high-risk-for-psychosis-age-related-differences-in-attenuated-positive-symptoms-syndrome-prevalence-and-entanglement-with-basic-symptoms
#18
M Gerstenberg, A Theodoridou, N Traber-Walker, M Franscini, D Wotruba, S Metzler, M Müller, D Dvorsky, C U Correll, S Walitza, W Rössler, K Heekeren
BACKGROUND: The attenuated positive symptoms syndrome (APSS) is considered an at-risk indicator for psychosis. However, the characteristics and developmental aspects of the combined or enriched risk criteria of APSS and basic symptom (BS) criteria, including self-experienced cognitive disturbances (COGDIS) remain under-researched. METHOD: Based on the Structured Interview of Prodromal Syndromes (SIPS), the prevalence of APSS in 13- to 35-year-old individuals seeking help in an early recognition program for schizophrenia and bipolar-spectrum disorders was examined...
April 2016: Psychological Medicine
https://www.readbyqxmd.com/read/26604770/early-stages-of-pediatric-bipolar-disorder-retrospective-analysis-of-a-czech-inpatient-sample
#19
Michal Goetz, Tomas Novak, Marie Vesela, Zdenek Hlavka, Martin Brunovsky, Michal Povazan, Radek Ptacek, Antonin Sebela
BACKGROUND: Approximately 30%-60% of adults diagnosed with bipolar disorder (BD) report onset between the ages 15 and 19 years; however, a correct diagnosis is often delayed by several years. Therefore, investigations of the early features of BD are important for adequately understanding the prodromal stages of the illness. METHODS: A complete review of the medical records of 46 children and adolescents who were hospitalized for BD at two psychiatric teaching centers in Prague, Czech Republic was performed...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/26578415/-description-of-clinical-and-neurocognitive-profiles-in-offspring-of-bipolar-type-i-parents-from-a-multimodal-intervention-program-prisma
#20
Juan David Palacio-Ortíz, Esteban Uribe-Villa, Paula Duque-Ríos, Paola Gutiérrez-Briceño, Violeta Zapata-Henao, Cristian Esteban Peña-Quintero, Carlos López-Jaramillo
INTRODUCTION: Offspring of bipolar parents are a high risk population for the develop of mental diseases, their study allow determining the genetic risk, early symptoms, prodromes and psychopathology of bipolar disorder. OBJECTIVE: To describe the psychopathological characteristics and neurocognitives profiles of the offspring of bipolar type I parents. And to identify the presence of sub-syndromal symptoms in all the symptom domains. METHODS: A descriptive and cross-sectional study was conducted on 110 offspring between 6 and 30 years old...
July 2015: Revista Colombiana de Psiquiatría
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