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Bipolar prodromal

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https://www.readbyqxmd.com/read/28503109/parental-reports-of-prodromal-psychopathology-in-pediatric-bipolar-disorder
#1
Mariely Hernandez, Ciro Marangoni, Marie C Grant, Jezelle Estrada, Gianni L Faedda
OBJECTIVES: Early psychopathology in children diagnosed with Bipolar Disorder (BD) remains poorly characterized. Parental retrospective reports provide helpful details on the earliest manifestations and their evolution over time. These symptoms occur early in the course of BD, often before a formal diagnosis is made and/or treatment is implemented, and are of great importance to early recognition and prevention. METHODS: Parents of pre-pubertal children and adolescents with DSM-IV diagnoses of BD attending an outpatient mood disorders clinic provided retrospective ratings of 37 symptoms of child psychopathology...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28499209/precursors-in-adolescence-of-adult-onset-bipolar-disorder
#2
Ayako Hiyoshi, Julia A Sabet, Hugo Sjöqvist, Carren Melinder, Robert J Brummer, Scott Montgomery
BACKGROUND: Although the estimated contribution of genetic factors is high in bipolar disorder, environmental factors may also play a role. This Swedish register-based cohort study of men examined if physical and psychological characteristics in late adolescence, including factors previously linked with bipolar disorder (body mass index, asthma and allergy), are associated with subsequent bipolar disorder in adulthood. Unipolar depression and anxiety are analysed as additional outcomes to identify bipolar disorder-specific associations...
April 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28437056/psychotic-and-bipolar-disorders-schizophrenia
#3
Alaina L Edmunds
Schizophrenia is the most common psychotic illness, typically appearing between the late teenage years and the mid-30s. The first episode of psychosis may be preceded by a prodromal period. Schizophrenia symptoms fall into six common symptom clusters: delusions and hallucinations, disorganization of speech, cognitive dysfunction, negative symptoms, affective symptoms, and motor system abnormalities. The diagnosis is based on criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, including exclusion of other possible medical or psychiatric etiologies of psychosis...
April 2017: FP Essentials
https://www.readbyqxmd.com/read/28396906/the-lausanne-geneva-cohort-study-of-offspring-of-parents-with-mood-disorders-methodology-findings-current-sample-characteristics-and-perspectives
#4
Caroline L Vandeleur, Marie-Pierre F Strippoli, Enrique Castelao, Mehdi Gholam-Rezaee, François Ferrero, Pierre Marquet, Jean-Michel Aubry, Martin Preisig
PURPOSE: Studies focusing on the offspring of affected parents utilize the well-established familial aggregation of mood disorders as a powerful tool for the identification of risk factors, early clinical manifestations, and prodromes of mood disorders in these offspring. The major goals of the Lausanne-Geneva mood cohort study are to: (1) assess the familial aggregation of bipolar and unipolar mood disorders; (2) prospectively identify risk factors for mood disorders as well as their early signs and prodromes; (3) identify their endophenotypes including cognitive features, alterations in brain structure, HPA-axis dysregulation, and abnormalities of the circadian rhythm of activity...
April 10, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28376919/eye-movement-desensitization-and-reprocessing-therapy-versus-supportive-therapy-in-affective-relapse-prevention-in-bipolar-patients-with-a-history-of-trauma-study-protocol-for-a-randomized-controlled-trial
#5
Ana Moreno-Alcázar, Joaquim Radua, Ramon Landín-Romero, Laura Blanco, Mercè Madre, Maria Reinares, Mercè Comes, Esther Jiménez, Jose Manuel Crespo, Eduard Vieta, Victor Pérez, Patricia Novo, Marta Doñate, Romina Cortizo, Alicia Valiente-Gómez, Walter Lupo, Peter J McKenna, Edith Pomarol-Clotet, Benedikt L Amann
BACKGROUND: Up to 60% of patients with bipolar disorder (BD) have a history of traumatic events, which is associated with greater episode severity, higher risk of comorbidity and higher relapse rates. Trauma-focused treatment strategies for BD are thus necessary but studies are currently scarce. The aim of this study is to examine whether Eye Movement Desensitization and Reprocessing (EMDR) therapy focusing on adherence, insight, de-idealisation of manic symptoms, prodromal symptoms and mood stabilization can reduce episode severity and relapse rates and increase cognitive performance and functioning in patients with BD...
April 4, 2017: Trials
https://www.readbyqxmd.com/read/28373798/the-turkish-adaptation-validity-and-reliability-of-the-internal-states-scale
#6
Zeynep Maçkali, Cengiz Akkaya, Ömer Aydemir
INTRODUCTION: The Internal State Scale (ISS) was developed to simultaneously assess manic and depressive symptoms in bipolar disorder. In the present study, the validity and reliability of the Turkish version of ISS (ISS-TR) were examined. The present study aimed to present the psychometric properties of this scale. METHODS: The sample consisted of 200 outpatients with bipolar disorder and 49 healthy controls. Participants completed the Turkish Internal State Scale (ISS-TR), the Brief Psychiatric Rating Scale (BPRS), the Hamilton Depression Rating Scale (HDRS), and the Young Mania Rating Scale (YMRS)...
September 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28365466/early-clinical-predictors-and-correlates-of-long-term-morbidity-in-bipolar-disorder
#7
G Serra, A Koukopoulos, L De Chiara, A E Koukopoulos, G Sani, L Tondo, P Girardi, D Reginaldi, R J Baldessarini
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD). METHODS: We analyzed factors associated with total, depressive and mania-related long-term morbidity and their ratio D/M, as %-time ill between a first-lifetime major affective episode and last follow-up of 207 BD subjects. Bivariate comparisons were followed by multivariable linear regression modeling...
February 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28287195/-pilot-study-on-nutritional-and-eating-disorders-in-children-and-mood-disorders-comorbidity-or-prodromal-traits
#8
Paola Cimbolli, Álvaro Quiñones, Carla Ugarte, Adele De Pascale
INTRODUCTION: Both children affected by nutritional and eating disorders (ED) and adults with bipolar disorder (BD) display symptoms of deficient emotional self-regulation, which can present in different forms. If we observe the clinical and developmental histories of individuals affected by EDs and BD, based on a cognitive systemic post-rationalist approach, we can hypothesise a continuum between the two disorders. The aim of this pilot study is to support the hypothesis - from an explanatory rather than a non-descriptive approach - that EDs and BD are the possible result of issues tied to biological and psychological self-regulation...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28283835/a-developmental-approach-to-dimensional-expression-of-psychopathology-in-child-and-adolescent-offspring-of-parents-with-bipolar-disorder
#9
María Goretti Morón-Nozaleda, Covadonga M Díaz-Caneja, Elisa Rodríguez-Toscano, Celso Arango, Josefina Castro-Fornieles, Elena de la Serna, Ana Espliego, Vanessa Sanchez-Gistau, Soledad Romero, Immaculada Baeza, Gisela Sugranyes, Carmen Moreno, Dolores Moreno
The aim of this is to describe psychopathology, functioning and symptom dimensions accounting for subthreshold manifestations and developmental status in child and adolescent offspring of parents with bipolar disorder ("high-risk offspring"). The study population comprised 90 high-risk offspring (HR-offspring) and 107 offspring of community control parents (CC-offspring). Direct clinical observations and parental and offspring reports based on selected standardized clinical scales were used to assess offspring threshold and subthreshold diagnoses, symptoms and functioning...
March 10, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28155207/prodrome-or-risk-syndrome-what-s-in-a-name
#10
Pierre Alexis Geoffroy, Jan Scott
BACKGROUND: In the last decade, an increasing number of publications have examined the precursors of bipolar disorders (BD) and attempted to clarify the early origins and illness trajectory. This is a complex task as the evolution of BD often shows greater heterogeneity than psychosis, and the first onset episode of BD may be dominated by depressive or manic features or both. To date, most of the published reviews have not clarified whether they are focused on prodromes, risk syndromes or addressing both phenomena...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27993232/cortical-morphology-characteristics-of-young-offspring-of-patients-with-schizophrenia-or-bipolar-disorder
#11
Gisela Sugranyes, Cristina Solé-Padullés, Elena de la Serna, Roger Borras, Soledad Romero, Vanessa Sanchez-Gistau, Clemente Garcia-Rizo, Jose Manuel Goikolea, Nuria Bargallo, Dolores Moreno, Inmaculada Baeza, Josefina Castro-Fornieles
OBJECTIVE: Cortical surface area and thickness abnormalities have been observed in patients with schizophrenia and bipolar disorders; however, no study thus far has examined cortical morphologic measurements in children and adolescents at genetic risk for the disorders comparatively. METHOD: One hundred thirty-seven participants, including 36 offspring of patients with schizophrenia (SzO), 54 offspring of patients with bipolar disorder (BpO), and 47 offspring of community controls (CcO), 6 to 17 years old, were assessed with clinical and neuroimaging methods...
January 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27993229/development-of-two-dimensional-measures-of-restricted-and-repetitive-behavior-in-parents-and-children
#12
David W Evans, Mirko Uljarević, Laina G Lusk, Eva Loth, Thomas Frazier
OBJECTIVE: Restricted and repetitive behaviors (RRBs) are a heterogeneous set of behaviors common across a wide range of neurodevelopmental disorders (NDDs) and neuropsychiatric disorders (NPDs) that extend well into the general population. This study introduces 2 dimensional measurements of RRBs for use in typical and clinical populations from infancy to adulthood. METHOD: The Childhood Routines Inventory-Revised (CRI-R) and the Adult Routines Inventory (ARI) were created and administered online to a nationally representative cohort of 3,108 parents with 3,032 children (range 12 months to 17 years 11 months)...
January 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27830449/understanding-early-age-of-onset-a-review-of-the-last-5%C3%A2-years
#13
REVIEW
Gabrielle A Carlson, Caroly Pataki
The age at onset of bipolar disorder ranging from childhood to adolescent to adult has significant implications for frequency, severity and duration of mood episodes, comorbid psychopathology, heritability, response to treatment, and opportunity for early intervention. There is increasing evidence that recognition of prodromal symptoms in at-risk populations and mood type at onset are important variables in understanding the course of this illness in youth. Very early childhood onset of symptoms including anxiety/depression, mood lability, and subthreshold manic symptoms, along with family history of a parent with early onset bipolar disorder, appears to predict the highest risk of early onset disorder with the most severe course...
December 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27806866/neurofunctional-differences-among-youth-with-and-at-varying-risk-for-developing-mania
#14
Jeffrey A Welge, Lawrence J Saliba, Jeffrey R Strawn, James C Eliassen, L Rodrigo Patino, Caleb M Adler, Wade Weber, Marguerite Reid Schneider, Drew H Barzman, Stephen M Strakowski, Melissa P DelBello, Robert K McNamara
OBJECTIVE: To examine prefrontal and amygdala activation during emotional processing in youth with or at varying risk for developing mania to identify candidate central prodromal risk biomarkers. METHOD: Four groups of medication-free adolescents (10-20 years old) participated: adolescents with first-episode bipolar I disorder (BP-I; n = 32), adolescents with a parent with bipolar disorder and a depressive disorder (at-risk depressed [ARD]; n = 32), healthy adolescents with a parent with bipolar disorder (at-risk healthy [ARH]; n = 32), and healthy adolescents with no personal or family history of psychiatric illness (healthy comparison [HC]; n = 32)...
November 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27802240/bipolar-disorder-and-frontotemporal-dementia-an-intriguing-association
#15
Apostolos Papazacharias, Madia Lozupone, Maria Rosaria Barulli, Rosa Capozzo, Bruno P Imbimbo, Federica Veneziani, Roberto De Blasi, Marcello Nardini, Davide Seripa, Francesco Panza, Giancarlo Logroscino
Bipolar disorder (BD) could represent a prodromal state of frontotemporal dementia (FTD). Two patients affected by lifelong BD with a progressive decline of cognitive functions, behavioral, and neurological signs, reached the early diagnosis of FTD before the age of 60. They were diagnosed as affected by primary progressive aphasia and FTD with parkinsonism, respectively. A diagnosis of FTD should therefore be taken into account, in case of unexpected cognitive and behavioral decline in patients with a long history of BD...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27737475/pharmacotherapy-in-children-and-adolescents-at-clinical-high-risk-for-psychosis-and-bipolar-disorder
#16
REVIEW
M Lambert, V Niehaus, C Correll
This review aims to describe the importance of i) detecting individuals at clinical high-risk for psychosis (schizophrenia) or bipolar disorder, especially in children and adolescents, in order to enable early intervention, and ii) evaluating different intervention strategies, especially pharmacotherapy, during the subsyndromal or "prodromal" stages of these severe and often debilitating disorders. The different approaches regarding the psychotic and bipolar clinical high-risk state are discussed, including reasons and evidence for early (pharmacological) intervention and risks of treatment vs...
November 2016: Pharmacopsychiatry
https://www.readbyqxmd.com/read/27522263/characterizing-psychosis-risk-traits-in-africa-a-longitudinal-study-of-kenyan-adolescents
#17
Daniel Mamah, Abednego Musau, Victoria N Mutiso, Akinkunle Owoso, Arbi Ben Abdallah, Linda B Cottler, Catherine W Striley, Elaine F Walker, David M Ndetei
The schizophrenia prodrome has not been extensively studied in Africa. Identification of prodromal behavioral symptoms holds promise for early intervention and prevention of disorder onset. Our goal was to investigate schizophrenia risk traits in Kenyan adolescents and identify predictors of psychosis progression. 135 high-risk (HR) and 142 low-risk (LR) adolescents were identified from among secondary school students in Machakos, Kenya, using the structured interview of psychosis-risk syndromes (SIPS) and the Washington early recognition center affectivity and psychosis (WERCAP) screen...
October 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27488129/parental-reports-of-prodromal-psychopathology-in-pediatric-bipolar-disorder
#18
Mariely Hernandez, Ciro Marangoni, Marie C Grant, Jezelle Estrada, Gianni L Faedda
OBJECTIVES: Objectives: Early psychopathology in children diagnosed with Bipolar Disorder (BD) remains poorly characterized. Parental retrospective reports provide helpful details on the earliest manifestations and their evolution over time. These symptoms occur early in the course of BD, often before a formal diagnosis is made and/or treatment is implemented, and are of great importance to early recognition and prevention. METHODS: Parents of pre-pubertal children and adolescents with DSM-IV diagnoses of BD attending an outpatient mood disorders clinic provided retrospective ratings of 37 symptoms of child psychopathology...
August 1, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27344625/affective-disorders-as-potential-complication-of-anti-acne-treatment-with-isotretinoin-a-case-series
#19
Karakula-Juchnowicz Hanna, Kowal-Popczak Agnieszka, Dzikowski Michal, Juchnowicz Dariusz, Dzikowska Izabela, Makarewicz Agata, Dubas-Slemp Halina
OBJECTIVE: To analyse cases of 9 patients (18-27 yo) who were consequently admitted to our department and treated with affective disorders (AD) while undergoing isotretinoin (INN) therapy. METHODS: A semi-structured questionnaire designed by the authors was used to analyse many variables related to demographic characteristics, dermatologic and psychiatrics symptoms, AD course and treatment, family history of mental disorders, building on medical histories of patients and their families, and available medical records...
November 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27343882/the-bipolar-prodrome-meta-analysis-of-symptom-prevalence-prior-to-initial-or-recurrent-mood-episodes
#20
REVIEW
Anna R Van Meter, Coty Burke, Eric A Youngstrom, Gianni L Faedda, Christoph U Correll
OBJECTIVE: The aim of this study was to meta-analyze the prevalence of symptoms before an initial mood episode of bipolar disorder (BD) and the prevalence of subthreshold symptoms before a BD mood episode recurrence, to facilitate early identification and prevention. METHOD: Systematic literature reviews were conducted in PsycINFO and PubMed for prospective or retrospective studies reporting on the prevalence and longest duration of symptoms before an initial or recurrent mood episode of BD...
July 2016: Journal of the American Academy of Child and Adolescent Psychiatry
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