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https://www.readbyqxmd.com/read/29674982/delusional-themes-across-affective-and-non-affective-psychoses
#1
Angelo Picardi, Laura Fonzi, Mauro Pallagrosi, Antonella Gigantesco, Massimo Biondi
The current debate about the diagnostic significance of delusion revolves around two positions. The neurocognitive position conceives delusion as a non-specific, though polymorphic, symptom. The psychopathological position views features of delusion such as content and structure as having meaningful connections with diagnostic entities. This study aims at contributing to this debate by examining the association between delusional themes and diagnosis in a sample of 830 adult psychotic patients. All diagnoses were made by experienced psychiatrists according to DSM-IV or ICD-10 criteria, and in 348 patients were established with the SCID-I...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29671754/a-review-of-physiological-and-behavioral-monitoring-with-digital-sensors-for-neuropsychiatric-illnesses
#2
Erik Reinertsen, Gari D Clifford
Physiological, behavioral, and psychological changes associated with neuropsychiatric illness are reflected in several related signals, including actigraphy, location, word sentiment, voice tone, social activity, heart rate, and responses to standardized questionnaires. These signals can be passively monitored using sensors in smartphones, wearable accelerometers, Holter monitors, and multimodal sensing approaches that fuse multiple data types. Connection of these devices to the internet has made large scale studies feasible and is enabling a revolution in neuropsychiatric monitoring...
April 19, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29659789/bipolar-disorder-in-primary-care-a-qualitative-study-of-clinician-and-patient-experiences-with-diagnosis-and-treatment
#3
Joseph M Cerimele, John C Fortney, Jeffrey M Pyne, Geoffrey M Curran
Objective: To understand primary care patients' and clinicians' experiences with diagnosis and treatment of patients with bipolar disorder in primary care. Methods: We conducted a qualitative study using thematic content analysis of individual interviews with nine primary care clinicians and six patients from Federally Qualified Health Centers to understand their experiences with the diagnosis and treatment of bipolar disorder. Results: Themes of bipolar disorder detection, referral to specialty mental health care and medication treatment emerged from individual interviews with primary care patients and clinicians...
April 5, 2018: Family Practice
https://www.readbyqxmd.com/read/29659209/improving-the-diagnosis-and-treatment-of-pediatric-bipolar-disorder
#4
Robert L Findling, Kiki D Chang
​​Reconsidering Insomnia as a Disorder Rather Than Just a Symptom in Psychiatric Practice Click to enlarge page Awareness of the prevalence and impact of bipolar disorder in pediatric patients has grown in recent years. Youths with this disorder are at risk for poor long-term outcomes, but with careful screening, clinicians may be able to detect early signs or subthreshold symptoms and provide a timely diagnosis and effective treatment. Although several pharmacologic options are available for patients aged 10 years and up, they differ in their safety and tolerability profiles...
March 27, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29655654/factorial-structure-and-familial-aggregation-of-the-hypomania-checklist-32-hcl-32-results-of-the-nimh-family-study-of-affective-spectrum-disorders
#5
Jennifer Glaus, Anna Van Meter, Lihong Cui, Ciro Marangoni, Kathleen R Merikangas
BACKGROUND: There is substantial evidence that bipolar disorder (BD) manifests on a spectrum rather than as a categorical condition. Detection of people with subthreshold manifestations of BD is therefore important. The Hypomania Checklist-32 (HCL-32) was developed as a tool to identify such people. PURPOSE: The aims of this paper were to: (1) investigate the factor structure of HCL-32; (2) determine whether the HCL-32 can discriminate between mood disorder subtypes; and (3) assess the familial aggregation and cross-aggregation of hypomanic symptoms assessed on the HCL with BD...
April 3, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29650011/physical-activity-and-chronic-diseases-among-older-people-in-a-mid-size-city-in-china-a-longitudinal-investigation-of-bipolar-effects
#6
Peiling Zhou, Anne K Hughes, Sue C Grady, Li Fang
BACKGROUND: While previous studies have shown that regular physical activity can delay the onset of certain chronic diseases; less is known about the changes in physical activity practices following chronic disease diagnoses. China is experiencing a rapid aging transition, with physical activity an important routine in many older people's lives. This study utilizes the Health Belief Model to better understand the bidirectional relationships and bipolar effects between physical activity and chronic disease burden in Huainan City, a mid-sized city in China...
April 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29643331/electroencephalographic-delta-alpha-frequency-activity-differentiates-psychotic-disorders-a-study-of-schizophrenia-bipolar-disorder-and-methamphetamine-induced-psychotic-disorder
#7
REVIEW
Fleur M Howells, Hendrik S Temmingh, Jennifer H Hsieh, Andrea V van Dijen, David S Baldwin, Dan J Stein
Electroencephalography (EEG) has been proposed as a neurophysiological biomarker to delineate psychotic disorders. It is known that increased delta and decreased alpha, which are apparent in psychosis, are indicative of inappropriate arousal state, which leads to reduced ability to attend to relevant information. On this premise, we investigated delta/alpha frequency activity, as this ratio of frequency activity may serve as an effective neurophysiological biomarker. The current study investigated differences in delta/alpha frequency activity, in schizophrenia (SCZ), bipolar I disorder with psychotic features and methamphetamine-induced psychosis...
April 12, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29625762/effectiveness-of-preventive-cognitive-therapy-while-tapering-antidepressants-versus-maintenance-antidepressant-treatment-versus-their-combination-in-prevention-of-depressive-relapse-or-recurrence-drd-study-a-three-group-multicentre-randomised-controlled-trial
#8
Claudi L H Bockting, Nicola S Klein, Hermien J Elgersma, Gerard D van Rijsbergen, Christien Slofstra, Johan Ormel, Erik Buskens, Jack Dekker, Peter J de Jong, Willem A Nolen, Aart H Schene, Steven D Hollon, Huibert Burger
BACKGROUND: Keeping individuals on antidepressants after remission or recovery of major depressive disorder is a common strategy to prevent relapse or recurrence. Preventive cognitive therapy (PCT) has been proposed as an alternative to maintenance antidepressant treatment, but whether its addition would allow tapering of antidepressants or enhance the efficacy of maintenance antidepressant treatment is unclear. We aimed to compare the effectiveness of antidepressants alone, with PCT while tapering off antidepressants, or PCT added to antidepressants in the prevention of relapse and recurrence...
April 3, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29608925/transdiagnostic-and-diagnosis-specific-dynamic-functional-connectivity-anchored-in-the-right-anterior-insula-in-major-depressive-disorder-and-bipolar-depression
#9
Yajing Pang, Heng Chen, Yifeng Wang, Zhiliang Long, Zongling He, Huangbin Zhang, Wei Liao, Qian Cui, Huafu Chen
Dysfunctional and abnormal functional connectivity in the right anterior insula (rAI) may underlie the pathophysiology of depression episode in bipolar disorder (BD) and of major depressive disorder (MDD). In this study, we examined the dynamic functional connectivity (dFC) of the rAI of 30 patients with BD, 30 patients with MDD, and 30 healthy controls. In the functional separation of rAI, the right dorsal AI (rdAI) and ventral AI (rvAI) were defined as seed regions. Sliding-window correlation of rAI subregions was implemented to measure the variance of dFC...
March 30, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29601407/effect-of-valproate-and-antidepressant-drugs-on-clozapine-metabolism-in-patients-with-psychotic-mood-disorders
#10
Donatella Marazziti, Lionella Palego, Laura Betti, Gino Giannaccini, Enrico Massimetti, Stefano Baroni, Antonio Ciapparelli, Antonio Lucacchini, Federico Mucci, Liliana Dell'Osso
BACKGROUND: The aim of the present study was to appraise retrospectively the influence of valproate (VPA) and antidepressants (ADs) on the steady-state plasma concentrations of clozapine (CLZ), the prototype of various second-generation antipsychotics (SGAs), norclozapine (NCLZ, its main metabolite), and their ratio (NCLZ/CLZ). METHODS: Sixty-seven psychotic patients with a prevalent diagnosis of bipolar disorder (BD) were studied. We then analyzed data altogether and subdivided them into four groups, according to pharmacological treatments: #1 CLZ (n=21), #2 CLZ plus antidepressants (ADs) (n=13), #3 CLZ plus VPA (n=16), and #4 CLZ plus ADs plus VPA (n=17)...
March 29, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29587954/-psychiatric-symptoms-in-patients-with-huntington-s-disease
#11
Rasmus Nejst Jensen, Tom Bolwig, Sven Asger Sørensen
Huntington's disease is an inherited neuropsychiatric disorder characterized by a triad of symptoms: motor, cognitive and psychiatric. Psychiatric symptoms occur prior to the motor symptoms in approximately 50% of the cases, and knowledge of the psychiatric symptoms is essential in making an early diagnosis. In this article, we argue that further knowledge of the genetic background of Huntington's disease may contribute to a better understanding of the polygenetic psychiatric diseases such as schizophrenia and bipolar affective disorder...
March 26, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29580906/post-traumatic-psychiatric-disorders-ptsd-is-not-the-only-diagnosis
#12
Yann Auxéméry
Traumatic events and their consequences are often hidden or minimised by patients for reasons linked to the post-traumatic stress disorder itself (inexpressibility, shame, depressive thoughts, fear of stigmatisation, etc.). Although post-traumatic stress disorder (PTSD) remains the most widely known disorder, chronic post-traumatic psychiatric disorders are many and varied. After a trauma, the practitioner has to check for the different clinical forms of post-traumatic psychological consequences: PTSD is not the only diagnosis...
March 23, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29580768/functional-connectivity-between-anterior-insula-and-key-nodes-of-frontoparietal-executive-control-and-salience-networks-distinguish-bipolar-depression-from-unipolar-depression-and-healthy-control-subjects
#13
Kristen K Ellard, Jared P Zimmerman, Navneet Kaur, Koene R A Van Dijk, Joshua L Roffman, Andrew A Nierenberg, Darin D Dougherty, Thilo Deckersbach, Joan A Camprodon
BACKGROUND: Patients with bipolar depression are characterized by dysregulation across the full spectrum of mood, differentiating them from patients with unipolar depression. The ability to switch neural resources among the default mode network, salience network, and executive control network (ECN) has been proposed as a key mechanism for adaptive mood regulation. The anterior insula is implicated in the modulation of functional network switching. Differential connectivity between anterior insula and functional networks may provide insights into pathophysiological differences between bipolar and unipolar mood disorders, with implications for diagnosis and treatment...
February 7, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29580740/negative-voice-content-as-a-full-mediator-of-a-relation-between-childhood-adversity-and-distress-ensuing-from-hearing-voices
#14
Cherise Rosen, Simon McCarthy-Jones, Nev Jones, Kayla A Chase, Rajiv P Sharma
A key predictor of whether or not an individual who hears voices (auditory verbal hallucinations; AVH) meets criteria for a psychiatric diagnosis is the level of negative content of the voices (e.g., threats, criticism, abuse). Yet the factors that contribute to negative voice-content are still not well understood. This study aimed to test the hypotheses that levels of childhood adversity would predict levels of negative voice-content, and that negative voice-content would partially mediate a relation between childhood adversity and voice-related distress...
March 23, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29579109/using-data-linkage-to-electronic-patient-records-to-assess-the-validity-of-selected-mental-health-diagnoses-in-english-hospital-episode-statistics-hes
#15
Katrina Alice Southworth Davis, Oliver Bashford, Amelia Jewell, Hitesh Shetty, Robert J Stewart, Cathie L M Sudlow, Matthew Hugo Hotopf
BACKGROUND: Administrative data can be used to support research, such as in the UK Biobank. Hospital Episode Statistics (HES) are national data for England that include contain ICD-10 diagnoses for inpatient mental healthcare episodes, but the validity of these diagnoses for research purposes has not been assessed. METHODS: 250 peoples' HES records were selected based on a HES recorded inpatient stay at the South London and Maudsley NHS Foundation Trust with a diagnosis of schizophrenia, a wider schizophrenia spectrum disorder, bipolar affective disorder or unipolar depression...
2018: PloS One
https://www.readbyqxmd.com/read/29576229/are-post-acute-patients-with-behavioral-health-disorders-admitted-to-lower-quality-nursing-homes
#16
Helena Temkin-Greener, Lauren Campbell, Xuyea Cai, Michael J Hasselberg, Yue Li
OBJECTIVES: We measured the proportion of new post-acute nursing home admissions with behavioral health diagnoses and examined whether patients with these disorders (schizophrenia/psychosis, bipolar, depression/anxiety, personality disorder, and substance abuse) faced disparities in access to high quality facilities. SETTING/PARTICIPANTS: The analytical sample included 3,729,282 admissions to 15,600 facilities nationwide for 2012-2014. MEASUREMENT: Quality was measured for overall and staffing domains reported by the Centers for Medicare and Medicaid Services in the Five-Star Quality Rating System...
February 28, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29565503/study-on-the-epigenetic-methylation-modification-of-bipolar-disorder-major-genes
#17
H-S Zhang, X-Y Ke, L-L Hu, J Wang, L-S Gao, J Xie
OBJECTIVE: We aimed to study changes and possible roles of epigenetic modification of candidate genes in the pathogenesis of bipolar disorder, and provide the basis for clinical diagnosis and analysis. PATIENTS AND METHODS: A total of 150 patients with bipolar disorder were enrolled in this study from January 2014 to June 2015; also, 50 healthy subjects were enrolled as control group. The patients were followed up for 18 months and followed up once every 3 months to review the methylation status...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29544775/a-yinyang-bipolar-fuzzy-cognitive-topsis-method-to-bipolar-disorder-diagnosis
#18
Ying Han, Zhenyu Lu, Zhenguang Du, Qi Luo, Sheng Chen
BACKGROUND AND OBJECTIVE: Bipolar disorder is often mis-diagnosed as unipolar depression in the clinical diagnosis. The main reason is that, different from other diseases, bipolarity is the norm rather than exception in bipolar disorder diagnosis. YinYang bipolar fuzzy set captures bipolarity and has been successfully used to construct a unified inference mathematical modeling method to bipolar disorder clinical diagnosis. Nevertheless, symptoms and their interrelationships are not considered in the existing method, circumventing its ability to describe complexity of bipolar disorder...
May 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29544167/glutamatergic-hypofunction-in-medication-free-major-depression-secondary-effects-of-affective-diagnosis-and-relationship-to-peripheral-glutaminase
#19
Toby Wise, Matthew J Taylor, Andres Herane-Vives, Antonella Marino Gammazza, Francesco Cappello, David J Lythgoe, Steve Cr Williams, Allan H Young, Anthony J Cleare, Danilo Arnone
BACKGROUND: There is uncertainty as to whether alterations in glutamatergic function in affective disorders differ between unipolar and bipolar disorders and between depressive and euthymic states. Additionally, there are currently no available blood-based markers of central glutamatergic function to support clinical diagnosis and aid brain based investigations. METHODS: In this study, we measured levels of glutamate in the dorsal anterior cingulate cortex in-vivo using 1H-Magnetic Resonance Spectroscopy in medication free unipolar and bipolar patients (n = 29, 20 unipolar and 9 bipolar) experiencing a major depressive episode, in comparison with a group of matched healthy controls (n = 20)...
February 27, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29542331/suprasensory-phenomena-in-those-with-a-bipolar-disorder
#20
Gordon Parker, Amelia Paterson, Mia Romano, Isabelle Granville Smith
OBJECTIVES: To increase awareness of the sensory changes experienced during hypo/manic and depressive states by those with a bipolar disorder and determine if the prevalence of such features is similar across differing bipolar sub-types. METHODS: We interviewed 66 patients who acknowledged sensory changes during hypo/manic states. They were allocated to bipolar I, bipolar II and soft bipolar diagnostic categories and the prevalence of 10 differing sensory changes was quantified during hypo/manic and depressive phases...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
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