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https://www.readbyqxmd.com/read/29342363/differential-effects-of-inhibitory-g-protein-isoforms-on-g-protein-gated-inwardly-rectifying-k-currents-in-adult-murine-atria
#1
Muriel Nobles, David Montaigne, Sonia Sebastian, Lutz Birnbaumer, Andrew Tinker
G-protein gated inwardly rectifying K+ (GIRK) channels are the major inwardly rectifying K+ currents in cardiac atrial myocytes and an important determinant of atrial electrophysiology. Inhibitory G-protein alpha subunits can both mediate activation via acetylcholine but can also supress basal currents in the absence of agonist. We studied this phenomenon using whole cell patch clamping in murine atria from mice with global genetic deletion of Gαi2, combined deletion of Gαi1/Gαi3 and littermate controls...
January 17, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29342313/collagen-xii-myopathy-with-rectus-femoris-atrophy-and-collagen-xii-retention-in-fibroblasts
#2
Nanna Witting, Thomas Krag, Ulla Werlauff, Morten Duno, Sofie Thuroe Oestergaard, Julia Rebecka Dahlqvist, John Vissing
INTRODUCTION: Mutation in the collagen XII gene (COL12A1) was recently reported to induce Bethlem myopathy. We describe a family affected by collagen XII-related myopathy in 3 generations. METHODS: Systematic interview, clinical examination, skin biopsies and MRI muscle. RESULTS: The phenotype was characterized by neonatal hypotonia, contractures and delayed motor development followed by resolution of contractures and a motor performance limited by reduced endurance...
January 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29342262/preliminary-study-of-1940-nm-thulium-laser-usage-in-peroral-endoscopic-myotomy-for-achalasia
#3
J Liu, Y Jiao, Y Niu, L Yu, M Ji, S Zhang
Esophageal achalasia is a type of motility disorder characterized by incomplete relaxation of lower esophageal sphincter (LES) and absence of esophageal peristalsis. Peroral endoscopic myotomy (POEM) is a new treatment option for achalasia that is less invasive, more effective, and safe as compared to surgery. High-frequency electrotome is commonly used in POEM, but takes longer time to make the tunnel in the esophagus and causes many complications. The thulium laser decreases the risk of bleeding and perforation in endoscopy but has not been reported in digestive diseases, especially in POEM...
January 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29342236/magnamwar-an-r-package-for-genome-wide-association-studies-of-bacterial-orthologs
#4
Corinne E Sexton, Hayden Z Smith, Peter D Newell, Angela E Douglas, John M Chaston
Summary: Here we report on an R package for genome-wide association studies of orthologous genes in bacteria. Before using the software, orthologs from bacterial genomes or metagenomes are defined using local or online implementations of OrthoMCL. These presence-absence patterns are statistically associated with variation in user-collected phenotypes using the Mono-Associated GNotobiotic Animals Metagenome-Wide Association R package (MAGNAMWAR). Genotype-phenotype associations can be performed with several different statistical tests based on the type and distribution of the data...
January 12, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29342192/white-matter-tract-specific-quantitative-analysis-in-multiple-sclerosis-comparison-of-optic-radiation-reconstruction-techniques
#5
Chenyu Wang, Alexander Klistorner, Linda Ly, Michael H Barnett
The posterior visual pathway is commonly affected by multiple sclerosis (MS) pathology that results in measurable clinical and electrophysiological impairment. Due to its highly structured retinotopic mapping, the visual pathway represents an ideal substrate for investigating patho-mechanisms in MS. Therefore, a reliable and robust imaging segmentation method for in-vivo delineation of the optic radiations (OR) is needed. However, diffusion-based tractography approaches, which are typically used for OR segmentation are confounded by the presence of focal white matter lesions...
2018: PloS One
https://www.readbyqxmd.com/read/29342177/a-new-fluorescent-dye-accumulation-assay-for-parallel-measurements-of-the-abcg2-abcb1-and-abcc1-multidrug-transporter-functions
#6
Edit Szabó, Dóra Türk, Ágnes Telbisz, Nóra Kucsma, Tamás Horváth, Gergely Szakács, László Homolya, Balázs Sarkadi, György Várady
ABC multidrug transporters are key players in cancer multidrug resistance and in general xenobiotic elimination, thus their functional assays provide important tools for research and diagnostic applications. In this study we have examined the potential interactions of three key human ABC multidrug transporters with PhenGreen diacetate (PGD), a cell permeable fluorescent metal ion indicator. The non-fluorescent, hydrophobic PGD rapidly enters the cells and, after cleavage by cellular esterases, in the absence of quenching metal ions, PhenGreen (PG) becomes highly fluorescent...
2018: PloS One
https://www.readbyqxmd.com/read/29342050/intraoperative-cochlear-implant-device-testing-utilizing-an-automated-remote-system-a-prospective-pilot-study
#7
Amanda R Lohmann, Matthew L Carlson, Douglas P Sladen
INTRODUCTION: Intraoperative cochlear implant device testing provides valuable information regarding device integrity, electrode position, and may assist with determining initial stimulation settings. Manual intraoperative device testing during cochlear implantation requires the time and expertise of a trained audiologist. The purpose of the current study is to investigate the feasibility of using automated remote intraoperative cochlear implant reverse telemetry testing as an alternative to standard testing...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29342028/lymphedema-distichiasis-syndrome-in-a-male-patient-followed-for-16-years
#8
Ana Beatriz D Grisolia, Christine C Nelson
Distichiasis is a challenging condition that may require multiple surgical interventions. Besides ophthalmologic concerns in children, distichiasis may be part of the lymphedema-distichiasis syndrome, which presents with lymphedema of variable time of onset. Other significant systemic disorders such as coarctation of the aorta and varicose veins have been reported in association with this syndrome and must be reviewed for proper patient care. The authors report the case of a 22-year-old male patient who had been treated for distichiasis and followed for 16 years...
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29341953/lethality-among-patients-with-hiv-aids-monitored-in-the-clinic-of-infectious-diseases-in-st-george-university-hospital-plovdiv-2010-2014
#9
Mariyana V Stoycheva, Nikolay T Vatev, Vania B Georgieva, Antonina P Dineva, Maria V Atanasova, Tatiana A Popova
BACKGROUND: The introduction of complex antiretroviral therapy has resulted in signifi cant decrease in the mortality rate of HIV positive patients, but it still remains unacceptably high, especially in some groups of patients. AIM: To investigate the death rate in patients with HIV/AIDS, lethality and mortality in co-infection, and the most common causes and predictors of fatal outcome, focused on early diagnosis and appropriate therapy. MATERIALS AND METHODS: The study included 53 deceased patients with HIV/AIDS, monitored at the Clinic of Infectious Diseases in St George University Hospital, Plovdiv between 01...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29341932/synthetic-extracellular-matrix-mimic-hydrogel-improves-efficacy-of-mesenchymal-stromal-cell-therapy-for-ischemic-cardiomyopathy
#10
Maria Chiara Ciuffreda, Giuseppe Malpasso, Cindy Chokoza, Deon Bezuidenhout, Kyle P Goetsch, Manuela Mura, Federica Pisano, Neil H Davies, Massimiliano Gnecchi
BACKGROUND: Mesenchymal stromal cells (MSC) repair infarcted hearts mainly through paracrine mechanisms. Low cell engraftment limits the release of soluble paracrine factors (SF) over time and, consequently, MSC efficacy. We tested whether a synthetic extracellular matrix mimic, a hydrogel containing heparin (H-HG), could ameliorate MSC engraftment and binding/release of SF, thus improving MSC therapy efficacy. METHODS AND RESULTS: In vitro, rat bone-marrow MSC (rBM-MSC) were seeded and grown into H-HG...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29341911/an-efficient-pegylated-gene-delivery-system-with-improved-targeting-synergism-between-octaarginine-and-a-fusogenic-peptide
#11
Ikramy A Khalil, Hideyoshi Harashima
Because of their ability to translocate different cargos into cells, arginine-rich cell penetrating peptides (CPPs) are promising vehicles for drug and gene delivery. The use of CPP-based carriers, however, is hampered by the lack of specificity and by interactions with negative serum components. Polyethylene glycol (PEG) is used to decrease such non-specific interactions, albeit its use is associated with reduced transfection efficiency. In this study, we describe the development of PEGylated CPP-based gene carrier with an improved targeting and a high transfection activity...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341868/transcriptional-evidence-for-crosstalk-between-ja-and-et-or-sa-during-root-knot-nematode-invasion-in-tomato
#12
Wenchao Zhao, Xiaoxuan Zhou, Hui Lei, Jingwei Fan, Rui Yang, Zilong Li, Canli Hu, Mengyan Li, Fukuan Zhao, Shaohui Wang
Previous studies have demonstrated that jasmonic acid (JA) reduces root-knot nematode (RKN) infections in tomato plants. RKN invasion is sensed by roots, and root-derived JA signaling activates systemic defense responses, though this is poorly understood. Here, we investigate variations in the RKN-induced transcriptome in scion phloem between two tomato plant grafts: CM/CM (Lycopersicum esculentum Mill. cv. Castlemart) and CM/spr2 (a JA-deficient mutant). A total of 8,716 genes were differentially expressed in the scion phloem of the plants with JA-deficient rootstock...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29341734/vapor-induced-motion-of-liquid-droplets-on-an-inert-substrate
#13
Xingkun Man, Masao Doi
Evaporating droplets are known to show complex motion that has conventionally been explained by the Marangoni effect (flow induced by the gradient of surface tension). Here, we show that the droplet motion can be induced even in the absence of the Marangoni effect due to the gradient of the evaporation rate. We derive an equation for the velocity of a droplet subject to the nonuniform evaporation rate and nonuniform surface tension placed on an inert substrate, where the wettability is uniform and unchanged...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341708/high-precision-probe-of-the-fully-sequential-decay-width-of-the-hoyle-state-in-12-c
#14
D Dell'Aquila, I Lombardo, G Verde, M Vigilante, L Acosta, C Agodi, F Cappuzzello, D Carbone, M Cavallaro, S Cherubini, A Cvetinovic, G D'Agata, L Francalanza, G L Guardo, M Gulino, I Indelicato, M La Cognata, L Lamia, A Ordine, R G Pizzone, S M R Puglia, G G Rapisarda, S Romano, G Santagati, R Spartà, G Spadaccini, C Spitaleri, A Tumino
The decay path of the Hoyle state in ^{12}C (E_{x}=7.654  MeV) has been studied with the ^{14}N(d,α_{2})^{12}C(7.654) reaction induced at 10.5 MeV. High resolution invariant mass spectroscopy techniques have allowed us to unambiguously disentangle direct and sequential decays of the state passing through the ground state of ^{8}Be. Thanks to the almost total absence of background and the attained resolution, a fully sequential decay contribution to the width of the state has been observed. The direct decay width is negligible, with an upper limit of 0...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341690/anomalous-nonlocal-resistance-and-spin-charge-conversion-mechanisms-in-two-dimensional-metals
#15
Chunli Huang, Y D Chong, Miguel A Cazalilla
We uncover two anomalous features in the nonlocal transport behavior of two-dimensional metallic materials with spin-orbit coupling. First, the nonlocal resistance can have negative values and oscillate with distance, even in the absence of a magnetic field. Second, the oscillations of the nonlocal resistance under an applied in-plane magnetic field (the Hanle effect) can be asymmetric under field reversal. Both features are produced by direct magnetoelectric coupling, which is possible in materials with broken inversion symmetry but was not included in previous spin-diffusion theories of nonlocal transport...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341671/ab%C3%A2-initio-exchange-correlation-free-energy-of-the-uniform-electron-gas-at-warm-dense-matter-conditions
#16
Simon Groth, Tobias Dornheim, Travis Sjostrom, Fionn D Malone, W M C Foulkes, Michael Bonitz
In a recent Letter [T. Dornheim et al., Phys. Rev. Lett. 117, 156403 (2016)PRLTAO0031-900710.1103/PhysRevLett.117.156403], we presented the first quantum Monte Carlo (QMC) results for the warm dense electron gas in the thermodynamic limit. However, a complete parametrization of the exchange-correlation free energy with respect to density, temperature, and spin polarization remained out of reach due to the absence of (i) accurate QMC results below θ=k_{B}T/E_{F}=0.5 and (ii) QMC results for spin polarizations different from the paramagnetic case...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341661/entanglement-hamiltonians-for-chiral-fermions-with-zero-modes
#17
Israel Klich, Diana Vaman, Gabriel Wong
In this Letter, we study the effect of topological zero modes on entanglement Hamiltonians and the entropy of free chiral fermions in (1+1)D. We show how Riemann-Hilbert solutions combined with finite rank perturbation theory allow us to obtain exact expressions for entanglement Hamiltonians. In the absence of the zero mode, the resulting entanglement Hamiltonians consist of local and bilocal terms. In the periodic sector, the presence of a zero mode leads to an additional nonlocal contribution to the entanglement Hamiltonian...
September 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341651/lattice-homotopy-constraints-on-phases-of-quantum-magnets
#18
Hoi Chun Po, Haruki Watanabe, Chao-Ming Jian, Michael P Zaletel
The Lieb-Schultz-Mattis (LSM) theorem and its extensions forbid trivial phases from arising in certain quantum magnets. Constraining infrared behavior with the ultraviolet data encoded in the microscopic lattice of spins, these theorems tie the absence of spontaneous symmetry breaking to the emergence of exotic phases like quantum spin liquids. In this work, we take a new topological perspective on these theorems, by arguing they originate from an obstruction to "trivializing" the lattice under smooth, symmetric deformations, which we call the "lattice homotopy problem...
September 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341446/carboxytherapy-for-treatment-of-localized-chronic-plaque-psoriasis-clinical-and-histopathologic-evaluation
#19
Abeer Mostafa Kamel, Rania Abdelghani
BACKGROUND: Multiple treatment options are introduced in treatment of chronic localized plaque psoriasis but with poor adherence and poor patients' satisfaction resulting in poor treatment outcome. OBJECTIVE: In this pilot study, we investigated the safety and efficacy of carboxytherapy in treatment of chronic localized plaque psoriasis. METHODS: Thirty adult patients with chronic localized plaque psoriasis were enrolled in this study. The patients received carboxytherapy injection once/week for 8 weeks...
January 17, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29341419/fatty-liver-index-predicts-incident-diabetes-in-a-japanese-general-population-with-and-without-impaired-fasting-glucose
#20
Aya Hirata, Daisuke Sugiyama, Kazuyo Kuwabara, Takumi Hirata, Hiromi Tsutatani, Mika Funamoto, Kouiti Watanabe, Naomi Miyamatsu, Tomonori Okamura
AIM: Fatty liver is associated with the development of diabetes. However, to our knowledge, no study has examined the relationship between the fatty liver index (FLI), calculated scores of hepatic steatosis, and the development of diabetes among individuals without impaired fasting glucose (IFG). We aimed to examine whether FLI predicts the development of diabetes in individuals with and without IFG in a Japanese general population. METHODS: We selected 1,498 males and 2,941 females who participated in Specific Health Checkups in Japan...
January 17, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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