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Esther Gil-Barrionuevo, José Maria Balibrea, Enric Caubet, Oscar Gonzalez, Ramón Vilallonga, José Manuel Fort, Andrea Ciudin, Manel Armengol
INTRODUCTION: Pheochromocytomas are infrequent tumors arised from the chromaphine cells of the adrenal sympathetic system. The excess of circulating catecholamines may lead to different cardiovascular disorders from silent alterations of the myocardial conduction to different forms of cardiomyopathy. The onset as cardiogenic shock is exceptional. PRESENTATION OF CASE: A 35-year-old male, with a known history of acute myopericarditis of unknown origin which debuted as acute pulmonary edema, was admitted with dyspnea in the context of a new heart failure episode with pulmonary edema...
June 27, 2018: International Journal of Surgery Case Reports
Kevin R Duque, Alejandro L Escalaya, Willy Zapata, Jorge G Burneo, Javier A Bustos, Isidro Gonzales, Herbert Saavedra, E Javier Pretell, Hector H Garcia
OBJECTIVE: Discordances between imaging findings of parenchymal neurocysticercosis and seizure expression have been reported, and as such the possibility that neurocysticercosis and seizures may frequently coexist by chance has been raised. In this study, we evaluate the topographic relationship between seizure foci based on semiology and electroencephalography with the location of parenchymal neurocysticercotic lesions. METHODS: Seizure information, neuroimaging (computed tomography and magnetic resonance imaging [MRI]) and electroencephalographic data from three randomized clinical trials of individuals with parenchymal neurocysticercosis and focal seizures were analyzed...
June 28, 2018: Epilepsy Research
Richard L Hesketh, Kevin M Brindle
Hyperpolarization of 13 C-labeled substrates can increase their 13 C NMR signal by more than 10000-fold, which has allowed magnetic resonance imaging (MRI) of metabolic reactions in vivo. This has already provided a unique insight into the dysregulated metabolic pathways and microenvironment of tumors. Perhaps the best known of the cancer-associated metabolic aberrations is the Warburg effect, which has been imaged in patients using hyperpolarized [1-13 C]pyruvate. In clinical oncology there is a requirement to diagnose tumors earlier, better determine their aggressiveness and prognosis, identify novel treatment targets and detect response to treatment earlier...
July 11, 2018: Current Opinion in Chemical Biology
Prasath Sathiah, Priyadarshini Dehuri, Debasis Gochhait
A 32 year old male patient presented at the fine needle aspiration (FNA) clinic with slow progressive swellings on bilateral Achilles tendon (Figure: 1 Left larger than right) for more than 3 years. The clinical diagnosis was bilateral giant cell tumor of tendon sheath. The patient also carried an MRI report (performed elsewhere- T2 weighted image) which highlighted the soft tissue lesions in the bilateral tendon with speckled hyperintensity and focal thickening (Figure II). This article is protected by copyright...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Rachel B Ger, Jinzhong Yang, Yao Ding, Megan C Jacobsen, Carlos E Cardenas, Clifton D Fuller, Rebecca M Howell, Heng Li, R Jason Stafford, Shouhao Zhou, Laurence E Court
PURPOSE: Magnetic resonance imaging (MRI) provides non-invasive evaluation of patient's anatomy without using ionizing radiation. Due to this and the high soft-tissue contrast, MRI use has increased and has potential for use in longitudinal studies where changes in patients' anatomy or tumors at different time points are compared. Deformable image registration can be useful for these studies. Here we describe two data sets that can be used to evaluate the registration accuracy of systems for MR images, as it cannot be assumed to be the same as that measured on CT images...
July 14, 2018: Medical Physics
Kurt G Schilling, Yurui Gao, Matthew Christian, Vaibhav Janve, Iwona Stepniewska, Bennett A Landman, Adam W Anderson
The squirrel monkey (Saimiri sciureus) is a commonly-used surrogate for humans in biomedical research. In the neuroimaging community, MRI and histological atlases serve as valuable resources for anatomical, physiological, and functional studies of the brain; however, no digital MRI/histology atlas is currently available for the squirrel monkey. This paper describes the construction of a web-based multi-modal atlas of the squirrel monkey brain. The MRI-derived information includes anatomical MRI contrast (i...
July 13, 2018: Neuroinformatics
Marco Ertreo, Hailey Choi, David Field, Jonathan W Lischalk, Emil Cohen, George E Lynskey, Theresa Caridi, Donna Buckley, Keith Unger, Alexander Y Kim
PURPOSE: To compare the use of cone-beam computed tomography versus contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the calculation of liver volume and planned dose for yttrium-90 radioembolization. MATERIALS AND METHODS: The study retrospectively assessed 47 consecutive patients who underwent resin Y-90 radioembolization consecutively over a 2-year period at a single center. Volume calculation software was used to determine perfused lobar liver volumes from cone-beam CT (CBCT) images obtained during mapping angiography...
July 13, 2018: Cardiovascular and Interventional Radiology
Takahiro Sueoka, Keizo Tanitame, Yukiko Honda, Takeshi Shoji, Takuma Yamasaki, Nobuo Adachi, Awai Kazuo
OBJECTIVES: To assess the utility of the radial reformation of three-dimensional fat-suppressed multi-echo gradient-recalled-echo (3D FS me-GRE) for evaluating acetabular labral injuries and femoroacetabular impingement (FAI). MATERIALS AND METHODS: A total of 25 patients with suspected acetabular labral injuries were examined using 3D FS me-GRE and radial 2D T2*-weighted imaging (T2*WI) on a 3-T magnetic resonance imaging (MRI) scanner. The range of acetabular labral injuries was evaluated by radial reformation through the center of the acetabulum perpendicular to the plane across the entire acetabular rim (type 1 radial reformation) of 3D FS me-GRE and radial 2D T2*WI...
July 13, 2018: Skeletal Radiology
Lesley J Scott
Intravenous gadobutrol [Gadovist™ (EU); Gadavist® (USA)] is a second-generation, extracellular non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is approved for use in paediatric (including term neonates) and adult patients undergoing diagnostic contrast-enhanced (CE) MRI for visualization of pathological lesions in all body regions or for CE MRA to evaluate perfusion and flow-related abnormalities. Its unique physicochemical profile, including its high thermostability and proton relaxation times, means that gadobutrol is formulated at twice the gadolinium ion concentration of other GBCAs, resulting in a narrower bolus and consequently, improved dynamic image enhancement...
July 13, 2018: Clinical Drug Investigation
Chao Miao, Lei Zhang, Ming Sun, Chao Ma
A 3 years old boy was hospitalized with a month's history of polydipsia, polyuria and low fever. There was no relevant family history. This is a rare case of Langerhans cell histiocytosis (LCH) with both bone and pituitary infiltration shown on the technetium-99m methylene diphosphonate (99m Tc-MDP) scan and brain magnetic resonance imaging (MRI). Sagittal and coronal T1-weighted images on MRI showed the typical lack of high signal intensity of the posterior pituitary which corresponded to the central signs of diabetes insipidus (DI)...
July 12, 2018: Hellenic Journal of Nuclear Medicine
Seol H Park, Minjung Seo, Hye-Jeong Choi, Kyungkyg Bae, Minseo Bang, Sungmin Jun
OBJECTIVE: To evaluate the reliability of a method using the peri-tumoral halo layer (PHL) for assessing tumor size in breast cancer patients on the fluorine-18-fluorodeoxy glucose positron emission tomography/computed tomography (18 F-FDG PET/CT) scan compared to MRI and pathology. SUBJECTS AND METHODS: Among 121 patients with breast cancer who underwent both 18 F-FDG PET/CT and MRI between March 2013 and June 2016, 59 patients were included in this study. Exclusion criteria were as follows: history of neoadjuvant therapy, history of pre-operative mammotome, insufficient pathologic/radiologic size report, clustered tumor, positive tumor resection margin, 18 F-FDG non-avid tumor...
July 12, 2018: Hellenic Journal of Nuclear Medicine
Ali Caglar Özen, Ergin Atalar, Jan G Korvink, Michael Bock
Magnetic resonance imaging (MRI) provides excellent cross-sectional images of the soft tissues in patients. Unfortunately, MRI is intrinsically slow, it exposes patients to severe acoustic noise levels, and is limited in the visualization of certain tissues such as bone. These limitations are partly caused by the timing structure of the MRI exam which first generates the MR signal by a strong radio-frequency excitation and later acquires the weak MRI signal. Concurrent excitation and acquisition (CEA) can overcome these limitations, but is extremely challenging due to the huge intensity difference between transmit and receive signal (up to 100 dB)...
July 13, 2018: Scientific Reports
Christine Muench, Melanie Schwandt, Jeesun Jung, Carlos R Cortes, Reza Momenan, Falk W Lohoff
Alcohol dependence (AD) frequently co-occurs with major depressive disorder (MDD). While this comorbidity is associated with an increase in disease burden, worse treatment outcomes, and greater economic costs, the underlying neurobiology remains poorly understood. A recent large-scale GWAS of MDD has identified a locus in the TMEM161B-MEF2C region (rs10514299) as a novel risk variant; however, the biological relevance of this variant has not yet been studied. Given previous reports of disrupted reward processing in both AD and MDD, we hypothesized that rs10514299 would be associated with differences in striatal BOLD responses during reward/loss anticipation in AD...
July 13, 2018: Translational Psychiatry
Michael Benson, Sang Lee, Ratul Bhattacharya, Valentino Vasy, Jamshed Zuberi, Sayeeda Yasmeen, Mutahar Ahmed, Moneer K Hanna
OBJECTIVE: To discuss the presenting features, imaging findings and recommended management of patients with Metanephric adenoma (MA) focusing on the diagnostic challenges and indications for follow up. MATERIALS AND METHODS: In this case report, we present a case of a 10-year-old female with MA who eventually underwent nephron sparing surgery with a partial nephrectomy. We performed a literature review of previous cases of metanephric adenoma and their respective management and follow-up...
July 10, 2018: Urology
Dimitri Martel, Benjamin Leporq, Mary Bruno, Ravinder Regatte, Stephen Honig, Gregory Chang
OBJECT: To quantify and compare subregional proximal femur bone marrow fat composition in premenopausal and postmenopausal women using chemical shift-encoded-MRI (CSE-MRI). MATERIALS AND METHODS: A multi gradient-echo sequence at 3 T was used to scan both hips of premenopausal (n = 9) and postmenopausal (n = 18) women. Subregional fat composition (saturation, poly-unsaturation, mono-unsaturation) was quantitatively assessed in the femoral head, femoral neck, Ward's triangle, greater trochanter, and proximal shaft in bone marrow adipose tissue and separately within red and yellow marrow adipose tissue...
July 10, 2018: Magnetic Resonance Imaging
H Acosta, A Jansen, B Nuscheler, T Kircher
The successful recovery from affective loss (i.e. bereavement, relationship breakup) has been linked to Adult Attachment Style (AAS), a personality trait. Up to now, the association between AAS, affective loss experiences and brain gray matter volume is unclear. In 192 healthy subjects we investigated the association between MRI brain gray matter volume, applying voxel based morphometry, AAS (Relationship Scales Questionnaire, subscales "avoidance" (AV) and "anxiety" (ANX)), and number of affective losses within the last 5 years (AL; List of Threatening Experiences Questionnaire)...
July 10, 2018: Neuroscience
Ying Lin, Junji Ma, Yue Gu, Shen Yang, Liman Man Wai Li, Zhengjia Dai
A wealth of research on resting-state functional MRI (R-fMRI) data has revealed modularity as a fundamental characteristic of the human brain functional network. The modular structure has recently been suggested to be overlapping, meaning that a brain region may engage in multiple modules. However, not only the overlapping modular structure remains inconclusive, the topological features and functional roles of overlapping regions are also poorly understood. To address these issues, the present work utilized the maximal-clique based multiobjective evolutionary algorithm to explore the overlapping modular structure of the R-fMRI data obtained from 57 young healthy adults...
July 10, 2018: NeuroImage
Irene Toldo, Claudia Maria Bonardi, Elisa Bettella, Roberta Polli, Giacomo Talenti, Alberto Burlina, Stefano Sartori, Alessandra Murgia
BACKGROUND: The ALDH7A1 gene is known to be responsible for autosomal recessive pyridoxine-dependent epilepsy (OMIM 266100). The phenotypic spectrum of ALDH7A1 mutations is very heterogeneous ranging from refractory epilepsy and neurodevelopmental delay, to multisystem neonatal disorder. AIM: The present study aims at describing the phenotype associated with a novel homozygous ALDH7A1 mutation and the spectrum of brain malformations associated with pyridoxine-dependent epilepsy...
July 3, 2018: European Journal of Paediatric Neurology: EJPN
Heather I Greenwood, Katerina Dodelzon, Janine T Katzen
New emerging breast imaging techniques have shown great promise in breast cancer screening, evaluation of extent of disease, and response to neoadjuvant therapy. Tomosynthesis, allows 3-dimensional imaging of the breast, and increases breast cancer detection. Fast abbreviated MRI has reduced time and costs associated with traditional breast MRI while maintaining cancer detection. Diffusion-weighted imaging is a functional MRI technique that does not require contrast and has shown potential in screening, lesion characterization and also evaluation of treatment response...
August 2018: Surgical Clinics of North America
Nathan Truex, Travis J Menge
This report discusses an unusual case of bilateral chronic exertional compartment syndrome (CECS) of the lower leg, a syndrome found mainly in young athletes. Pathophysiology includes exercise-induced muscle expansion against noncompliant fibro-osseous membranes separating compartments of the lower leg. A 24-year-old female distance runner with a history significant for misdiagnosed shin splints and tibial stress fracture presented with acute-on-chronic right lower leg pain. History revealed exertional pain and numbness, alleviated by rest...
July 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
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