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Kerri Wade, Shelly Summar, Emily Dewit
Childhood obesity is epidemic in the United States. School nurses are in a unique position to address weight with the students they serve. This article provides tools for school nurses to be able to conduct an obesity screening, demonstrate the basic skills of motivational interviewing in treatment of obesity in a school age child, and utilize the 12345 Fit-Tastic program in their practice. This article is the seventh and final article in a series on the topic of childhood obesity and the accompanying comorbidities...
March 2016: NASN School Nurse
Anish Thomas, Yuanbin Chen, Tinghui Yu, Ammara Gill, Vinay Prasad
Although considered a disease of the elderly, a subset of patients with mesothelioma are young (<40 years). The goal of this study was to understand their characteristics and outcomes. The Surveillance, Epidemiology, and End Results (SEER) database was used to extract mesothelioma cases (1990-2010). We modeled Kaplan-Meyer survival curves stratified by site of disease, and age of presentation. 2% (207 of 12345) of mesothelioma patients are young. Sex distribution is comparable among the young (51% males, 49% females); males predominated (78%, 22%) in the older cohort...
June 30, 2015: Oncotarget
Dusanee Thanaboripat, Chitti Thawai, Chokchai Kittiwongwattana, Chamroon Laosinwattana, Prommart Koohakan, Nonglak Parinthawong
An actinobacterial strain, DCWR9-8-2(T), was isolated from a leaf of Thai upland rice (Oryza sativa) collected in Chumporn province, Thailand. Strain DCWR9-8-2(T) is Gram-stain-positive aerobic bacteria that produce single spores directly on the vegetative hypha. Cell wall peptidoglycan of this strain exhibits meso-diaminopimelic acid and glycine, the reducing sugars of whole-cell hydrolysate are arabinose, glucose, ribose, xylose and small amount of mannose. The phospholipid profiles in the membrane are comprised of phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol, phosphatidylinositol mannosides...
November 2015: Journal of Antibiotics
Yan Zheng, Bing Yu, Danny Alexander, Teri A Manolio, David Aguilar, Josef Coresh, Gerardo Heiss, Eric Boerwinkle, Jennifer A Nettleton
Heart failure is more prevalent among African Americans than in the general population. Metabolomic studies among African Americans may efficiently identify novel biomarkers of heart failure. We used untargeted methods to measure 204 stable serum metabolites and evaluated their associations with incident heart failure hospitalization (n = 276) after a median follow-up of 20 years (1987-2008) by using Cox regression in data from 1,744 African Americans aged 45-64 years without heart failure at baseline from the Jackson, Mississippi, field center of the Atherosclerosis Risk in Communities (ARIC) Study...
August 15, 2013: American Journal of Epidemiology
Saori Kashima, Etsuji Suzuki, Toshiharu Okayasu, Razafimahatratra Jean Louis, Akira Eboshida, S V Subramanian
OBJECTIVE: To evaluate the association between proximity to a health center and early childhood mortality in Madagascar, and to assess the influence of household wealth, maternal educational attainment, and maternal health on the effects of distance. METHODS: From birth records of subjects in the Demographic and Health Survey, we identified 12565 singleton births from January 2004 to August 2009. After excluding 220 births that lacked global positioning system information for exposure assessment, odds ratios (ORs) and their 95% confidence intervals (CIs) for neonatal mortality and infant mortality were estimated using multilevel logistic regression models, with 12345 subjects (level 1), nested within 584 village locations (level 2), and in turn nested within 22 regions (level 3)...
2012: PloS One
Jeremy Michael Van Raamsdonk, Siegfried Hekimi
Reactive oxygen species (ROS) are toxic oxygen-containing molecules that can damage multiple components of the cell and have been proposed to be the primary cause of aging. The antioxidant enzyme superoxide dismutase (SOD) is the only eukaryotic enzyme capable of detoxifying superoxide, one type of ROS. The fact that SOD is present in all aerobic organisms raises the question as to whether SOD is absolutely required for animal life and whether the loss of SOD activity will result in decreased lifespan. Here we use the genetic model organism Caenorhabditis elegans to generate an animal that completely lacks SOD activity (sod-12345 worms)...
April 10, 2012: Proceedings of the National Academy of Sciences of the United States of America
Jiewei Wang, Jianli Zhang, Huancheng Pang, Yabo Zhang, Yuyi Li, Jinping Fan
A Gram-stain-negative, rod-shaped bacterium, designated strain Y9(T), was isolated from a soil sample collected in Ningxia Province in China and was characterized to determine its taxonomic position. Strain Y9(T) contained Q-8 as the predominant ubiquinone. Major fatty acid components were summed feature 3 (C(16:1)ω7c and/or iso-C(15:0) 2-OH) and C(16:0). The major polar lipids were phosphatidylethanolamine, phosphatidylglycerol and diphosphatidylglycerol. The G+C content of the genomic DNA of strain Y9(T) was 68...
March 2012: International Journal of Systematic and Evolutionary Microbiology
Apakorn Songsumanus, Somboon Tanasupawat, Chitti Thawai, Khanit Suwanborirux, Takuji Kudo
A novel actinomycete, strain P0402(T), was isolated from peat swamp forest soil collected in Thailand. Its taxonomic position was determined by using a polyphasic taxonomic approach. The chemotaxonomic characteristics of this strain matched those of the genus Micromonospora, i.e. the presence of meso-diaminopimelic acid and N-glycolyl muramic acid in the peptidoglycan, whole-cell sugar pattern D, phospholipid type II, and cellular fatty acid type 3b. Phylogenetic analysis based on 16S rRNA gene sequences revealed a close relationship between strain P0402(T) and Micromonospora coxensis JCM 13248(T) (99...
May 2011: International Journal of Systematic and Evolutionary Microbiology
Mike Reppert, Valter Zazubovich, Nhan C Dang, Michael Seibert, Ryszard Jankowiak
The CP43 protein complex of the core antenna of higher plant photosystem II (PSII) has two quasidegenerate "red" absorption states. It has been shown in the accompanying paper I (Dang, N. C., et al. J. Phys. Chem. B 2008, 112, 9921.) that the site distribution functions (SDFs) of red-states A and B are uncorrelated and the narrow holes are burned in subpopulations of chlorophylls (Chls) from states A and B that are the lowest-energy pigments in their particular CP43 complexes and cannot further transfer energy downhill...
August 14, 2008: Journal of Physical Chemistry. B
Nhan C Dang, Valter Zazubovich, Mike Reppert, Bhanu Neupane, Rafael Picorel, Michael Seibert, Ryszard Jankowiak
The CP43 core antenna complex of photosystem II is known to possess two quasi-degenerate "red"-trap states (Jankowiak, R. et al. J. Phys. Chem. B 2000, 104, 11805). It has been suggested recently (Zazubovich, V.; Jankowiak, R. J. Lumin. 2007, 127, 245) that the site distribution functions of the red states (A and B) are uncorrelated and that narrow holes are burned in the subpopulations of chlorophylls (Chls) from states A and B that are the lowest-energy Chl in their complex and previously thought not to transfer energy...
August 14, 2008: Journal of Physical Chemistry. B
Eric A Noe, Diwakar M Pawar, Frank R Fronczek
In the title compound, C(21)H(32)N(4)O(4), no disorder is present in the 15-membered hydrocarbon ring, which exists in an unsymmetrical quinquangular [12345] conformation. The 2,4-dinitrophenylhydrazone group is approximately perpendicular to the C(15) ring, with a dihedral angle of 84.66 (1) degrees between their best planes.
March 2008: Acta Crystallographica. Section C, Crystal Structure Communications
Vincenzo Triggiani, Edoardo Guastamacchia, Ivan Lolli, Giuseppe Troccoli, Francesco Resta, Carlo Sabbà, Nadia Ruggieri, Emilio Tafaro
There are few cases described in the world literature reporting an association of thymoma (with myasthenia gravis or not) with hyperparathyroidism. In these cases the hyperparathyroidism was due to the presence of an adenoma or hyperplasic parathyroid tissue either in the cervical region or in an ectopic intrathymic location.(12345) In other cases the syndrome of hypercalcemia was due to the secretion of parathyroid-related protein (PTHRP) (6) or parathyroid hormone (PTH) (7) by the thymoma itself. We report the first case, at the best of our knowledge, of a wide invasive malignant thymoma (type B3), associated with myasthenia gravis and hyperparathyroidism caused by parathyroid adenoma...
2006: Immunopharmacology and Immunotoxicology
Irena Gribovskaja, Kaleb C Brownlow, Sam J Dennis, Andrew J Rosko, Michael A Marletta, Regina Stevens-Truss
Like that of the neuronal nitric oxide synthase (nNOS), the binding of Ca(2+)-bound calmodulin (CaM) also regulates the activity of the inducible isoform (iNOS). However, the role of each of the four Ca(2+)-binding sites of CaM in the activity of iNOS is unclear. Using a series of single-point mutants of Drosophila melanogaster CaM, the effect that mutating each of the Ca(2+)-binding sites plays in the transfer of electrons within iNOS has been examined. The same Glu (E) to Gln (Q) mutant series of CaM used previously [Stevens-Truss, R...
May 24, 2005: Biochemistry
John A Monro
Faecal bulk may play an important role in preventing a range of disorders of the large bowel, but as yet there is little information available on the relative faecal bulking capacities of various foods. Breakfast cereals are often promoted as a good source of potential bulk for 'inner health' because they provide dietary fibre, but their relative abilities to provide faecal bulk per se have not been described. The faecal bulking efficacy of 28 representative Australasian breakfast cereals was therefore measured...
2002: Asia Pacific Journal of Clinical Nutrition
Keith H Christoffers, Arshia Khokhar, Kirti Chaturvedi, Richard D Howells
We reported recently that the ubiquitin-proteasome pathway is involved in agonist-induced down regulation of mu and delta opioid receptors [J. Biol. Chem. 276 (2001) 12345]. While evaluating the effects of various protease inhibitors on agonist-induced opioid receptor down regulation, we observed that while the peptide aldehyde, leupeptin (acetyl-L-Leucyl-L-Leucyl-L-Arginal), did not affect agonist-induced down regulation, leupeptin at submillimolar concentrations directly inhibited radioligand binding to opioid receptors...
April 15, 2002: Regulatory Peptides
L H Wang, R G Kalb, S M Strittmatter
M-SemF is a membrane-associated, neurally enriched member of the semaphorin family of axon guidance signals. We considered whether the cytoplasmic domain of M-SemF might possess a signaling function and/or might control the distribution of M-SemF on the cell surface. We identify a PDZ-containing neural protein as an M-SemF cytoplasmic domain-associated protein (SEMCAP-1). SEMCAP-2 is a closely related nonneuronal protein. SEMCAP-1 has recently also been identified as GIPC, by virtue of its interaction with the RGS protein GAIP in vitro (De Vries, L...
May 14, 1999: Journal of Biological Chemistry
B Wallace, C Tennant
OBJECTIVE: The aim of this study was to determine the need for nutrition intervention in a group of people living in mental health residential houses in the Northern Sydney Area. METHOD: A nutrition assessment was conducted by the researcher using a face-to-face interview with mental health residents and a survey on medical background completed by case managers. RESULTS: The prevalence of overweight and obesity was significantly greater than that reported for the general population...
February 1998: Australian and New Zealand Journal of Psychiatry
M A Lemmon, D Pinchasi, M Zhou, I Lax, J Schlessinger
Most growth factors and cytokines activate their receptors by inducing dimerization upon binding. We have studied binding of the dimeric cytokine stem cell factor (SCF) to the extracellular domain of its receptor Kit, which is a receptor tyrosine kinase similar to the receptors for platelet-derived growth factor and colony-stimulating factor-1. Calorimetric studies show that one SCF dimer binds simultaneously to two molecules of the Kit extracellular domain. Gel filtration and other methods show that this results in Kit dimerization...
March 7, 1997: Journal of Biological Chemistry
J S Franzen, M Zhang, T R Chay, C L Peebles
Conformational changes often accompany biological catalysis. Group II introns promote a variety of reactions in vitro that show an unusually sharp temperature dependence. This suggests that the chemical steps are accompanied by the conversion of a folded-but-inactive form to a differently folded active state. We report here the kinetic analysis of 5'-splice-junction hydrolysis (SJH) by E1:12345, a transcript containing the 5'-exon plus the first five of six intron secondary structure domains. The pseudo-first-order SJH reaction shows (1) activation by added KCl to 1...
September 20, 1994: Biochemistry
M J Dickerman
No abstract text is available yet for this article.
November 1968: NACDL Journal
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