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Variant angina

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https://www.readbyqxmd.com/read/27928223/impact-of-old-age-on-clinical-and-angiographic-characteristics-of-coronary-artery-spasm-as-assessed-by-acetylcholine-provocation-test
#1
Woong Gil Choi, Soo Hyun Kim, Seung-Woon Rha, Kang-Yin Chen, Yong-Jian Li, Byoung Geol Choi, Se Yeon Choi, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
BACKGROUND: Smoking and other risk factors have been well known as important factors of variant angina or coronary artery spasm (CAS). However, clinical features related to age on coronary artery spasm have been rarely evaluated. METHODS: We evaluated 3155 consecutive patients with insignificant coronary artery lesion. Patients underwent Acetylcholine (Ach) provocation test for induction of CAS. CAS was defined as > 70% luminal narrowing of coronary arteries during Ach provocation test...
October 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27921167/the-real-world-in-the-clinic-before-and-after-the-establishment-of-guidelines-for-coronary-artery-spasm-a-questionnaire-for-members-of-the-japanese-cine-angio-association
#2
Shozo Sueda, Hiroaki Kohno, Hideaki Yoshino
We investigated the clinical situations and the present knowledge of Japanese cardiologists about coronary artery spasm before and after the establishment of guidelines for this condition in the real world. A questionnaire was developed regarding the number of cases of coronary angiography, percutaneous coronary intervention, and invasive/non-invasive spasm provocation tests before (2008) and after (2014) the establishment of the Japanese Circulation Society (JCS) guidelines for coronary artery spasm and the status of spasm provocation tests...
December 5, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27904031/variant-aldehyde-dehydrogenase-2-aldh2-2-in-east-asians-interactively-exacerbates-tobacco-smoking-risk-for-coronary-spasm%C3%A3-possible-role-of-reactive-aldehydes
#3
Yuji Mizuno, Seiji Hokimoto, Eisaku Harada, Kenji Kinoshita, Michihiro Yoshimura, Hirofumi Yasue
BACKGROUND: Coronary spastic angina (CSA) is common among East Asians and tobacco smoking (TS) is an established risk factor for CSA. Aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing reactive toxic aldehydes and a deficient variant ALDH2 genotype (ALDH2*2) is prevalent among East Asians. We examined the interaction between TS andALDH2*2as a risk factor for CSA to better understand the disease pathogenesis.Methods and Results:The study subjects comprised 410 patients (258 men, 152 women; mean age, 66...
November 29, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27762117/bilateral-coronary-artery-fistula
#4
Abraham Speedie, Cinosh Mathew, Rashmi Kerr, Rajneesh Calton
Coronary artery anomalies include anomalies of origin, termination, structure or course. Coronary artery fistulae (CAF) are classified as abnormalities of termination and are considered a major congenital anomaly. A coronary artery fistula involves a sizable communication between a coronary artery, bypassing the myocardial capillary bed and entering either a chamber of the heart (coronary-cameral fistula) or a great vessel. Bilateral coronary artery fistula, are a rare variant. We describe a bilateral CAF with angina and significant coronary artery disease requiring percutaneous coronary intervention...
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27703634/cardiac-arrest-after-sugammadex-administration-in-a-patient-with-variant-angina-a-case-report
#5
Myoung Jin Ko, Yong Han Kim, Eunsu Kang, Byeong-Cheol Lee, Sujung Lee, Jae-Wook Jung
A 76-year-old man with no notable medical history was scheduled for a robot-assisted radical prostatectomy. After the operation, he was given sugammadex. Two minutes later, ventricular premature contraction bigeminy began, followed by cardiac arrest. Cardiac arrest occurred three times and cardiopulmonary resuscitation was done. The patient recovered after the third cardiopulmonary resuscitation and was transferred to the intensive care unit. Coronary angiography was done on postoperative day 1. The patient was diagnosed with variant angina and discharged uneventfully on postoperative day 8...
October 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27663770/association-of-cyp2c19-variants-and-epoxyeicosatrienoic-acids-on-patients-with-microvascular-angina
#6
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Yasuhiro Ogata, Kunihiko Matsui, Seiji Hokimoto
Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the association of CYP2C19 polymorphisms and EETs on microvascular angina (MVA) caused by coronary microvascular dysfunction. We examined CYP2C19 genotypes in patients with MVA (n = 71) and healthy subjects as control (n = 71)...
December 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27589045/a-subset-of-type-i-variant-kounis-syndrome-allergic-angina-syndrome-and-persistent-presence-of-coronary-spasm
#7
Hyung Il Kim, Kyoung Chul Cha, Yong Sung Cha, Oh Hyun Kim, Hyun Kim, Kang Hyun Lee, Min Soo Ahn, Jun Won Lee, Sung Oh Hwang
No abstract text is available yet for this article.
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27568854/development-of-protocatechualdehyde-proliposomes-based-sustained-release-pellets-with-improved-bioavailability-and-desired-pharmacokinetic-behavior-for-angina-chronotherapy
#8
Shuangshuang Zhang, Hongxiang Yan, Panpan Yu, Yulong Xia, Wenli Zhang, Jianping Liu
The present study was aimed to develope a proliposomal formulation to decrease the hepatic first-pass metabolism of protocatechualdehyde (PD), followed by pellet coating to modify the drug release for angina chronotherapy. PD proliposomes were prepared by depositing PD-phospholipid complex on mannitol powders to improve the drug encapsulation. Afterwards, the PD proliposomes were prepared into pellet cores via extrusion-spheronization using 10% κ-carrageenan as pelletization aid prior to the development of PD sustained-release pellets (PD-SRPs)...
October 10, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27494404/hdac9-variant-rs2107595-modifies-susceptibility-to-coronary-artery-disease-and-the-severity-of-coronary-atherosclerosis-in-a-chinese-han-population
#9
Xue-Bin Wang, Ya-di Han, Shrestha Sabina, Ning-Hua Cui, Shuai Zhang, Ze-Jin Liu, Cong Li, Fang Zheng
A previous genome-wide association study showed that a single nucleotide polymorphism (SNP) rs2107595 in histone deacetylase 9 (HDAC9) gene was associated with large artery stroke (LAS) in Caucasians. Based on the similar atherosclerotic pathogenesis between LAS and coronary artery disease (CAD), we aimed to evaluate the associations of SNP rs2107595 with CAD risk and the severity of coronary atherosclerosis in a Chinese Han population, and explore the potential gene-environment interactions among SNP rs2107595 and conventional CAD risk factors...
2016: PloS One
https://www.readbyqxmd.com/read/27484640/new-congenital-coronary-artery-anomaly-double-supply-of-single-left-anterior-descending-coronary-artery-from-the-left-and-right-coronary-sinuses-a-case-report
#10
Yunis Daralammouri, Malik Ghannam, Bernward Lauer
BACKGROUND: A normal anatomy of coronary arteries is important to have adequate cardiac muscle blood supply especially during extraneous physical activities. This case report describes a rare coronary anomaly in which the accessory coronary artery arose from the right coronary artery, reentered the left anterior descending coronary artery, and then ran as a single vessel. CASE PRESENTATION: We present a case of a coronary anomaly in a 47-year-old white man who presented with atypical angina...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27481084/a-patient-with-mushroom-allergy-a-new-etiological-agent-of-kounis-syndrome
#11
Fatma Merve Tepetam, Bahadır Dağdeviren, İsmet Bulut, Can Yücel Karabay, Safa Barış, Elif Aydıner Karakoç
Kounis syndrome (KS) is a rarely diagnosed condition which should always be kept in mind when an acute myocardial infarction (AMI) happens in the context of anaphylactic reactions. We report a case of a 31-year old female; 2 hours after the ingestion of the mushroom (Pleurotus ostreatus); she experienced nausea, stomachache, vomiting, dyspnea and chest pain. Electrocardiogram (ECG) showed an ST segment elevation in D1, AVL, precordial leads V1-V4. The blood analysis revealed high levels of CK-MB fraction and troponin T values...
December 0: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/27424315/stress-cardiomyopathy-is-it-limited-to-takotsubo-syndrome-problems-of-definition
#12
REVIEW
Petr A Sarapultsev, Alexey P Sarapultsev
In 2006, Takotsubo syndrome (TTC) was described as a distinct type of stress-induced cardiomyopathy (stress cardiomyopathy). However, when thinking about Takotsubo cardiomyopathy from the viewpoints of the AHA and ESC classifications, 2 possible problems may arise. The first potential problem is that a forecast of disease outcome is lacking in the ESC classification, whereas the AHA only states that 'outcome is favorable with appropriate medical therapy'. However, based on the literature data, one can make a general conclusion that occurrence of myocardial lesions in TTC (i...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27397091/polymorphism-in-endothelin-1-gene-an-overview
#13
Musa A Ahmed, Abir Rghigh
Endothelin-1, (ET-1, EDN1) is endogenous polypeptide demonstrates dominant vasoconstriction activity and mitogenic effect, on the heart it has positive inotropic and chronotropic properties, stimulates the sympathetic and the renin-angiotensin-aldosterone systems and modify homeostasis. The human ET-1 gene which consists of 6836 nucleotides located on chromosome 6p23-p24 produces Pre-pro-ET-1, which consequently cleaved to big-ET-1. The mature 21-amino acid ET-1 is generated by subsequent enzymatic cleavage of the big-ET-1...
June 30, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27386767/true-or-false-prognosis-is-excellent-for-sudden-cardiac-death-survivors-due-to-variant-angina
#14
EDITORIAL
Julia H Indik
No abstract text is available yet for this article.
July 12, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27386766/prognosis-of-variant-angina-manifesting-as%C3%A2-aborted-sudden-cardiac-death
#15
Jung-Min Ahn, Ki Hong Lee, Sang-Yong Yoo, Young-Rak Cho, Jon Suh, Eun-Seok Shin, Jae-Hwan Lee, Dong Il Shin, Sung-Hwan Kim, Sang Hong Baek, Ki Bae Seung, Chang-Wook Nam, Eun-Sun Jin, Se-Whan Lee, Jun-Hyok Oh, Jae Hyun Jang, Hyung Wook Park, Nam Sik Yoon, Jeong Gwan Cho, Cheol Hyun Lee, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Jun Kim, Young-Hak Kim, Ki-Byung Nam, Cheol Whan Lee, Kee-Joon Choi, Jae-Kwan Song, You-Ho Kim, Seong-Wook Park, Seung-Jung Park
BACKGROUND: The long-term prognosis of patients with variant angina presenting with aborted sudden cardiac death (ASCD) is unknown. OBJECTIVES: The purpose of this study was to evaluate the long-term mortality and ventricular tachyarrhythmic events of variant angina with and without ASCD. METHODS: Between March 1996 and September 2014, 188 patients with variant angina with ASCD and 1,844 patients with variant angina without ASCD were retrospectively enrolled from 13 heart centers in South Korea...
July 12, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27245239/clinical-spectrum-and-outcome-of-patients-with-non-st-segment-elevation-acute-coronary-syndrome-and-no-obstructive-coronary-atherosclerosis
#16
Gaetano A Lanza, Giulia Careri, Alessandra Stazi, Angelo Villano, Antonio De Vita, Cristina Aurigemma, Filippo Crea
BACKGROUND: Because approximately 10% of patients with no-ST-segment elevation acute coronary syndrome (NSTE-ACS) show no obstructive coronary artery disease (NOCAD) on angiography, we assessed the spectrum of diagnoses and the predictors of outcome of these patients. METHODS AND RESULTS: We studied 178 patients admitted to a coronary care unit with an initial diagnosis of NSTE-ACS, based on clinical, ECG and laboratory data, but found to have NOCAD. The final diagnosis in these patients was heterogeneous; true NSTE-ACS (ie, coronary thrombosis on an unstable plaque) was ascertained in 1 patient (0...
June 24, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27086958/-a-case-of-aspirin-exacerbated-respiratory-disease-complicated-by-refractory-variant-angina-which-showed-excellent-response-to-steroid-treatment
#17
Tatsuo Naito
A 47-year-old woman with aspirin-exacerbated respiratory disease visited our hospital complaining of persistent chest pain that manifested in the evenings and early mornings. Holter monitoring revealed ST elevation during chest pain and coronary angiography showed coronary vasospasm, which led to the diagnosis of variant angina. Chest pain persisted despite administration of a coronary vasodilator. The patient experienced an increase in peripheral blood eosinophils during the clinical course and received prednisolone for the same, which resulted in the resolution of her chest pain...
March 2016: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/27043695/incidence-and-risk-factors-associated-with-hospitalization-for-variant-angina-in-korea
#18
Hack-Lyoung Kim, Sang Hyung Lee, Jayeun Kim, Hyun Joo Kim, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim, Jin Yong Lee
This study aimed to determine the incidence and the risk factors of hospitalization for variant angina (VA) in Korean patients. Using the National Inpatient Sample (NIS) database, manufactured and released by the Health Insurance Review and Assessment Service (HIRA) in Korea, the incidence of hospitalization and rehospitalization for VA were calculated. The numbers of patients hospitalized for VA were estimated to be 14,362 in 2009, 17,492 in 2010, and 20,592 in 2011. The standardized incidence rates of hospitalization for VA were 31...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26995421/recurrent-chest-pain-after-treatment-of-spontaneous-coronary-artery-dissection-an-enigma
#19
Dheeraj D Bhatt, Ranjan Kachru, Sanjay Gupta, Upendra Kaul
Spontaneous coronary artery dissection (SCAD) is a rare entity. It has been described in various settings like pregnancy, collagen vascular diseases, cocaine abuse, heavy exercise, variant angina, eosinophilic arteritis, or fibro muscular dysplasia. It is also easy to miss a dissection during angiography, as the typical radiolucent lumen seen in coronary angiography may be absent in many cases. In this report, we describe the case of a 35-year-old female who presented with acute ST elevation myocardial infarction due to spontaneous coronary dissection...
December 2015: Indian Heart Journal
https://www.readbyqxmd.com/read/26966931/kounis-syndrome-an-update-on-epidemiology-pathogenesis-diagnosis-and-therapeutic-management
#20
Nicholas G Kounis
Kounis syndrome has been established as a hypersensitivity coronary disorder induced by various conditions, drugs, environmental exposures, foods and coronary stents. Allergic, hypersensitivity, anaphylactic and anaphylactoid reactions are associated with this syndrome. Vasospastic allergic angina, allergic myocardial infarction and stent thrombosis with occluding thrombus infiltrated by eosinophils and/or mast cells constitute are the three reported, so far, variants of this syndrome. Apart from coronary arteries, it affects the cerebral and mesenteric arteries...
October 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
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