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Mark D Ericson, Zoe M Koerperich, Katie T Freeman, Katlyn A Fleming, Carrie Haskell-Luevano
The melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R), endogenous agonists derived from the proopiomelanocortin gene transcript, and naturally-occurring antagonists agouti and agouti-related protein (AGRP) have been linked to biological pathways associated with energy homeostasis. The active tripeptide sequence of AGRP, Arg111-Phe112-Phe113, is located on a hypothesized β-hairpin loop. Herein, stereochemical modifications of the Arg-Phe-Phe sequence were examined in the octapeptide AGRP-derived macrocyclic scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was Asn or diaminopropionic acid (Dap)...
June 20, 2018: ACS Chemical Neuroscience
Marta Mateus, Marcus M Ilg, William J Stebbeds, Nim Christopher, Asif Muneer, David J Ralph, Selim Cellek
BACKGROUND: Peyronie's disease (PD) is a chronic fibrotic disease of the penis affecting a significant number of men worldwide without effective medical treatments. Myofibroblasts are pivotal in the pathogenesis of PD. Adenosine and adenosine receptors have been suggested to be involved in the pathophysiology of fibrosis. AIM: To understand the role of adenosine receptors in myofibroblast transformation in PD. METHODS: Fibroblasts were isolated from the non-PD tunica albuginea (TA) tissue and PD plaque tissue and were transformed into myofibroblasts using transforming growth factor (TGF)-β1...
June 8, 2018: Journal of Sexual Medicine
Miriam Hadj-Moussa, Dana A Ohl, William M Kuzon
BACKGROUND: Gender dysphoria is the experience of marked distress due to incongruence between genetically determined gender and experienced gender. Treatment of gender dysphoria should be individualized and multidisciplinary, involving a combination of psychotherapy, social gender transition, cross-sex hormone therapy, gender-affirming surgery, and/or ancillary procedures and services. The goal of all treatment modalities is to alleviate distress and affirm the patient's experienced gender identity...
June 8, 2018: Sexual Medicine Reviews
Alexander C Wilson, Dorothy V M Bishop
AIM: To test the hypothesis that sex chromosome trisomies (SCTs) are associated with reduced left lateralization for language. METHOD: Using a cross-sectional design, language laterality was measured during an animation description task using functional transcranial Doppler ultrasonography. Data were available for 75 children with an SCT (47,XXX females [n=26], 47,XXY males [n=25], 47,XYY males [n=24]; mean age 11y 4mo [SD 3y 10mo]) and 132 comparison children with typical karyotypes (69 males, 63 females; mean age 9y 1mo [SD 1y 7mo])...
June 10, 2018: Developmental Medicine and Child Neurology
Bing Liu, Linxin Zhu, Jingxiang Zhong, Guohua Zeng, Tuo Deng
INTRODUCTION: Phosphodiesterase type 5 inhibitors (PDE5-Is) are first-line drugs for erectile dysfunction. Non-arteritic anterior ischemic optic neuropathy (NAION) has been linked with PDE5-I use. However, no meta-analysis or conclusive review has explored the association between NAION and PDE5-I use. AIM: To investigate the association between PDE5-I use and risk of NAION. METHODS: A comprehensive literature search was conducted using online databases in October 2017 to obtain studies researching the association between PDE5-I application and occurrence of NAION...
June 5, 2018: Sexual Medicine
Michael Saheb Kashaf, Peter R Butler, Billy H Cordon-Galiano, Amin S Herati
BACKGROUND: The Institute of Medicine Report and Department of Health and Human Services Healthy People 2020 Initiative have called for steps to address health disparities facing sexual minorities. AIM: We sought to characterize the practice patterns of sexual health specialists as they relate to men who have sex with men (MSM). METHODS: Surveys were electronically mailed to 696 members of the Sexual Medicine Society of North America (SMSNA)...
June 5, 2018: Journal of Sexual Medicine
Eugene Shkolyar, Shufeng Li, Jean Tang, Michael L Eisenberg
BACKGROUND: Phosphodiesterase type 5 inhibitors (PDE5is), a treatment for erectile dysfunction, pulmonary hypertension (pHTN), and lower urinary tract symptoms (LUTS), have been implicated in melanoma development. AIM: We sought to determine the association between PDE5i use and melanoma development among patients with erectile dysfunction, pHTN, and LUTS. METHODS: This was a retrospective cohort study of subjects contained within the Truven Health MarketScan claims database, which provides information on insurance claims in the United States for privately insured individuals, from 2007-2015...
June 5, 2018: Journal of Sexual Medicine
Nannan Thirumavalavan, Billy H Cordon, Martin S Gross, Jeffrey Taylor, Jean-Francois Eid
BACKGROUND: Rear tip extenders (RTEs) are used commonly in penile prostheses, but their effect on erectile rigidity has not been extensively studied. AIM: To determine whether RTEs affect erectile rigidity in inflatable penile prostheses and determine what length of RTE should be used for a given corporal length-in this case, 22 cm. METHODS: To assess the effect of RTEs on erectile rigidity, we created a penile model simulating 2 corpora cavernosa that accommodated cylinders of varying lengths...
June 5, 2018: Journal of Sexual Medicine
Andréa Cronemberger Rufino, Alberto Madeiro, Adriana Silva Trinidad, Raiza Rodrigues Dos Santos, Isadora Freitas
BACKGROUND: Evidence shows that women who have sex with women (WSW) face disparities in access to health care when compared to heterosexual women in several countries. AIM: To investigate the experiences WSW have after disclosure of sexual orientation during gynecological care in Brazil. METHODS: We performed a qualitative study using content analysis. We recorded and transcribed interviews with 34 WSW from the 5 regions in Brazil. Data were analyzed using descriptive content analysis...
June 5, 2018: Journal of Sexual Medicine
Marc Neveu, Lindsay E Hays, Mary A Voytek, Michael H New, Mitchell D Schulte
We describe the history and features of the Ladder of Life Detection, a tool intended to guide the design of investigations to detect microbial life within the practical constraints of robotic space missions. To build the Ladder, we have drawn from lessons learned from previous attempts at detecting life and derived criteria for a measurement (or suite of measurements) to constitute convincing evidence for indigenous life. We summarize features of life as we know it, how specific they are to life, and how they can be measured, and sort these features in a general sense based on their likelihood of indicating life...
June 4, 2018: Astrobiology
Müjde Özer, Garry L S Pigot, Mark-Bram Bouman, Tim C van de Grift, Lian Elfering, Norah M van Mello, Hoda H M Al-Itejawi, Marlon E Buncamper, Margriet G Mullender
BACKGROUND: As genital gender-affirming surgery (GAS) is a demanding and life-changing intervention, transmen should be able to make choices about the surgical treatment based on outcomes that are most important to them, while taking into consideration the concomitant risks involved. AIM: Develop a decision aid (DA) for genital surgery in transmen (DA-GST) that can assist both transmen and health care professionals (HCPs) in making a well-informed decision about the surgical treatment...
May 31, 2018: Journal of Sexual Medicine
Desania Raquel Govender, Walter Wilhelm Focke, Shepherd Masimba Tichapondwa, William Edward Cloete
The energetics of cast calcium sulfate dihydrate-aluminium thermites was investigated. The casts were prepared form water slurries with a solids content of xxx wt-%. The base case thermite comprised 60 wt-% calcium sulfate dihydrate as the oxidiser with 40 wt-% aluminium as fuel. The heat of hydration of the base case was 59 ± 8 kJkg-1 and the setting time was zzz min. The compressive strength reached 2.9 ± 0.2 MPa after three days drying in ambient air. The open air burn rate was 12.0 ± 1.6 mm s-1 and a maximum surface temperature of 1370 ± 64 °C was recorded with a pyrometer...
May 29, 2018: ACS Applied Materials & Interfaces
Prapimporn Chattranukulchai Shantavasinkul, Michael J Muehlbauer, James R Bain, Olga R Ilkayeva, Damian M Craig, Christopher B Newgard, Laura P Svetkey, Svati H Shah, Alfonso Torquati
BACKGROUND: Gastric bypass surgery for weight reduction often corrects dysglycemia in diabetic patients, but a full understanding of the underlying biochemical pathways continues to be investigated. OBJECTIVES: To explore the effects of weight loss by surgical and dietary interventions on plasma metabolites using both targeted and discovery-oriented metabolomics platforms. SETTING: An academic medical center in the United States. METHODS: Improvement in homeostatic model assessment for insulin resistance (HOMA-IR), as an index of insulin resistance, was compared at 6 months in 11 patients that underwent Roux-en-Y gastric bypass against 11 patients that were matched for weight loss in the Weight Loss Maintenance (WLM) program...
April 17, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Paolo Verze, Davide Arcaniolo, Alessandro Palmieri, Tommaso Cai, Roberto La Rocca, Marco Franco, Luca Venturino, Marco De Sio, Vincenzo Mirone
INTRODUCTION: There is a great variability in the prevalence of premature ejaculation (PE) worldwide and only few data are available about the Italian population. AIM: To determine the prevalence of PE in the adult male population in Italy. METHODS: Adult men 18 to 80 years old who were sexually active were randomly sampled from patient lists of general practitioners in Italy and were included in this observational, non-interventional, cross-sectional epidemiologic study from January to July 2015...
May 23, 2018: Sexual Medicine
Alexander K Chow, Steven A Sidelsky, Laurence A Levine
BACKGROUND: There are limited data in the literature that describe the management of Peyronie's disease (PD) with severe compound curvature, which often requires additional straightening procedures after plaque excision and grafting (PEG) to achieve functional penile straightening (<20 degrees). AIM: This study highlights the clinical distinction and our experience with men with PD and severe compound curvature treated with PEG and supplemental tunica albuginea plication (TAP)...
May 22, 2018: Journal of Sexual Medicine
Leona K Shum, Mohamed A Bedaiwy, Catherine Allaire, Christina Williams, Heather Noga, Arianne Albert, Sarka Lisonkova, Paul J Yong
INTRODUCTION: Deep dyspareunia occurs in half of women with endometriosis, a condition present in 10% of reproductive-age women and associated with negative effects on sexual quality of life (SQoL). However, women with endometriosis can have other clinical factors (eg, superficial dyspareunia, other pelvic pains, and psychological or pain conditions) possibly affecting SQoL. AIMS: To determine whether deep dyspareunia is associated with SQoL in women with endometriosis, independent of potential confounders...
May 22, 2018: Sexual Medicine
Klaus Klarskov, Hugo Gagnon, Mathieu Racine, Pierre-Luc Boudreault, Chad Normandin, Eric Marsault, Gerald J Gleich, Stephen Naylor
The eosinophilia-myalgia syndrome (EMS) outbreak that occurred in the USA and elsewhere in 1989 was caused by the ingestion of Showa Denko K.K. (SD) L-tryptophan (L-Trp). "Six compounds" detected in the L-Trp were reported as case-associated contaminants. Recently the final and most statistically significant contaminant, "Peak AAA" was structurally characterized. The "compound" was actually shown to be two structural isomers resulting from condensation reactions of L-Trp with fatty acids derived from the bacterial cell membrane...
May 22, 2018: Toxicology Letters
Venkataswamy Eshwarachary, Priya Kadam, Sireesha Movva, Shruthi Lingaiah, Riyaz M Akther, Franics X Kidangan, Kiran C Gowda, Rudra R K Golakoti, Meena Lall, Surbhi Mahajan, Pushpa Saviour, Ratna Puri, Ishwar C Verma, Ramprasad L Vedam
INTRODUCTION: Non invasive prenatal testing (NIPT) is a reliable screening method for fetal aneuploidy detection of trisomy 18, 13, 21 along with few sex chromosome abnormalities monosomy X, XXX, XXY (Klinefelter), XYY (Jacob) syndromes and certain microdeletions which include cri-du-chat, DiGeorge, 1p36, Angelman and Prader-Willi syndromes in comparison to the available screening methods. Prenatal screening of Turners syndrome is possible by ultrasound in certain conditions only if there is complete loss of X chromosome...
May 24, 2018: Journal of Maternal-fetal & Neonatal Medicine
Fanjing Kong, Mianping Zheng, Bin Hu, Alian Wang, Nina Ma, Pablo Sobron
Since 2008, we have been studying a saline lake, Dalangtan (DLT) Playa, and its surroundings in a hyperarid region of the Qaidam Basin on the Tibetan Plateau as a potential Mars analog site. We describe the evolution of saline deposits in the Qaidam Basin (including DLT), based on investigative findings accumulated over the course of 60 years of geological surveys. In addition, we report regional meteorological patterns recorded for the past 32 years along with meteorological station recorded data at DLT since 2012...
May 24, 2018: Astrobiology
Jordan Rullo, Stephanie S Faubion, Rose Hartzell, Sue Goldstein, Deborah Cohen, Karla Frohmader, Ashley G Winter, Kristin Mara, Darrell Schroeder, Irwin Goldstein
BACKGROUND: Sexual dysfunction is often complex and biopsychosocial. Traditional sexual health care management involves individual providers not in a multi-disciplinary setting. A multi-disciplinary team may consist of a medical provider, pelvic floor physical therapist, and sex therapist. AIM: The aim was to explore the patient perceptions of benefit from management of their sexual dysfunction by a biopsychosocial multi-disciplinary team. METHODS: A survey was e-mailed to women patients seen by multi-disciplinary teams at 2 different settings: San Diego Sexual Medicine or Mayo Clinic Women's Health Clinic during a 27-month period...
May 19, 2018: Sexual Medicine
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