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https://www.readbyqxmd.com/read/29243932/role-of-aromatic-crosslinks-in-structure-and-dynamics-of-model-three-stranded-%C3%AE-sheet-peptides
#1
David Scheerer, Heng Chi, Dan McElheny, Ayesha Samer, Timothy A Keiderling, Karin Hauser
A series of closely related peptide sequences that form triple-strand structures were designed with a variation of cross-strand aromatic interactions and spectroscopically studied as models for β-sheet formation and stabilities. Structures of the three-strand models were determined with NMR methods and temperature-dependent equilibrium studies carried out using CD and FTIR spectroscopies. Our equilibrium data show that the presence of a direct cross-strand aromatic contact in an otherwise folded peptide does not automatically result in an increased thermal stability, and can even distort the structure...
December 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29241992/educational-content-and-the-use-of-social-media-at-us-departments-of-surgery
#2
Vahagn C Nikolian, Meredith Barrett, Valeria S Valbuena, Andrew M Ibrahim, Hassan Eidy, Mohamed H Ghandour, Amir A Ghaferi
BACKGROUND: The growth of the social media platform Twitter has prompted many to consider its potential as an educational tool. Little is known about how surgery training programs are utilizing this resource and whether this platform can provide educational content effectively. We sought to determine national utilization of Twitter by departments of surgery in the United States and evaluate if educationally driven content heightened engagement with the Twitter followers. METHODS: We conducted a cross-sectional analysis of social media presence for all Accreditation Council for Graduation Medical Education accredited general surgery training programs between October 1, 2016 and December 31, 2016...
December 11, 2017: Surgery
https://www.readbyqxmd.com/read/29241989/similar-degree-of-intimal-hyperplasia-in-surgically-detected-stenotic-and-nonstenotic-arteriovenous-fistula-segments-a-preliminary-report
#3
Juan C Duque, Marwan Tabbara, Laisel Martinez, Angela Paez, Guillermo Selman, Loay H Salman, Omaida C Velazquez, Roberto I Vazquez-Padron
BACKGROUND: Intimal hyperplasia has been historically associated with improper venous remodeling and stenosis after creation of an arteriovenous fistula. Recently, however, we showed that intimal hyperplasia by itself does not explain the failure of maturation of 2-stage arteriovenous fistulas. We seek to evaluate whether intimal hyperplasia plays a role in the development of focal stenosis of an arteriovenous fistula. METHODS: This study compares intimal hyperplasia lesions in stenotic and nearby nonstenotic segments collected from the same arteriovenous fistula...
December 11, 2017: Surgery
https://www.readbyqxmd.com/read/29229223/genders-and-individual-treatment-progress-in-non-binary-trans-individuals
#4
Andreas Koehler, Jana Eyssel, Timo O Nieder
BACKGROUND: Health care for transgender and transsexual (ie, trans) individuals has long been based on a binary understanding of gender (ie, feminine vs masculine). However, the existence of non-binary or genderqueer (NBGQ) genders is increasingly recognized by academic and/or health care professionals. AIM: To gain insight into the individual health care experiences and needs of binary and NBGQ individuals to improve their health care outcomes and experience. METHODS: Data were collected using an online survey study on experiences with trans health care...
December 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29227145/transport-induced-spatial-patterns-of-sulfur-isotopes-%C3%AE-34s-as-biosignatures
#5
Muammar Mansor, Khadouja Harouaka, Matthew S Gonzales, Jennifer L Macalady, Matthew S Fantle
Cave minerals deposited in the presence of microbes may host geochemical biosignatures that can be utilized to detect subsurface life on Earth, Mars, or other habitable worlds. The sulfur isotopic composition of gypsum (CaSO4·2H2O) formed in the presence of sulfur-oxidizing microbes in the Frasassi cave system, Italy, was evaluated as a biosignature. Sulfur isotopic compositions (δ34SV-CDT) of gypsum sampled from cave rooms with sulfidic air varied from -11 to -24‰, with minor deposits of elemental sulfur having δ34S values between -17 and -19‰...
December 11, 2017: Astrobiology
https://www.readbyqxmd.com/read/29224707/wide-variation-in-cost-of-surgical-care-for-parathyroidectomy-is-there-a-need-for-standardization-of-practice
#6
Samuel Jang, Meagan Mandabach, Zviadi Aburjania, Courtney J Balentine, Herbert Chen
BACKGROUND: Identifying hospital and provider variation in surgical cost is a potent method for controlling rising healthcare expenditure and delivering cost-effective care. The purpose of this study was to examine the variation of hospital cost by providers for parathyroidectomy in a single academic institution. METHODS: We retrospectively evaluated 894 consecutive parathyroidectomies under 8 surgeons in our institution between September 2011 and July 2016. Total duration of stay and cost were evaluated using nonparametric tests...
December 7, 2017: Surgery
https://www.readbyqxmd.com/read/29223771/comparative-studies-of-social-buffering-a-consideration-of-approaches-terminology-and-pitfalls
#7
REVIEW
Yasushi Kiyokawa, Michael B Hennessy
KIYOKAWA, Y. and HENNESSY, M.B. Social buffering of stress responses: A consideration of approaches, terminology, and pitfalls…NEUROSCI BIOBEHAV REV XXX-XXX, .- Over the past decades, there has been an increasing number of investigations of the impact of social variables on neural, endocrine, and immune outcomes. Among these are studies of "social buffering"-or the phenomenon by which affiliative social partners mitigate the response to stressors. Yet, as social buffering studies have become more commonplace, the variety of approaches taken, definitions employed, and divergent results obtained in different species can lead to confusion and miscommunication...
December 6, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29223328/shared-decision-making-during-surgical-consultation-for-gallstones-at-a-safety-net-hospital
#8
Krislynn M Mueck, Isabel M Leal, Charlie C Wan, Braden F Goldberg, Tamara E Saunders, Stefanos G Millas, Mike K Liang, Tien C Ko, Lillian S Kao
BACKGROUND: Understanding patient perspectives regarding shared decision-making is crucial to providing informed, patient-centered care. Little is known about perceptions of vulnerable patients regarding shared decision-making during surgical consultation. The purpose of this study was to evaluate whether a validated tool reflects perceptions of shared decision-making accurately among patients seeking surgical consultation for gallstones at a safety-net hospital. METHODS: A mixed methods study was conducted in a sample of adult patients with gallstones evaluated at a safety-net surgery clinic between May to July 2016...
December 6, 2017: Surgery
https://www.readbyqxmd.com/read/29223327/restoration-of-motor-function-after-operative-reconstruction-of-the-acutely-transected-spinal-cord-in-the-canine-model
#9
Zehan Liu, Shuai Ren, Kuang Fu, Qiong Wu, Jun Wu, Liting Hou, Hong Pan, Linlin Sun, Jian Zhang, Bingjian Wang, Qing Miao, Guiyin Sun, Vincenzo Bonicalzi, Sergio Canavero, Xiaoping Ren
BACKGROUND: Cephalosomatic anastomosis or what has been called a "head transplantation" requires full reconnection of the respective transected ends of the spinal cords. The GEMINI spinal cord fusion protocol has been developed for this reason. Here, we report the first randomized, controlled study of the GEMINI protocol in large animals. METHODS: We conducted a randomized, controlled study of a complete transection of the spinal cord at the level of T10 in dogs at Harbin Medical University, Harbin, China...
December 6, 2017: Surgery
https://www.readbyqxmd.com/read/29208538/sleep-related-painful-erections-a-meta-analysis-on-the-pathophysiology-and-risks-and-benefits-of-medical-treatments
#10
REVIEW
Sanne Vreugdenhil, Alida Cornelia Weidenaar, Igle Jan de Jong, Mels Frank van Driel
BACKGROUND: Patients with sleep-related painful erections (SRPEs) have frequent awakenings from deep penile pain during nocturnal erections. This results in severe sleep deprivation. AIM: To review the current literature on SRPEs and discuss the pathophysiologic theories and risks and benefits of medical treatments. METHODS: PubMed was searched using the terms sleep-related painful erections, nocturnal priapism, treatment, and sleep-related erections...
December 2, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29203286/an-opportunity-for-improvement-in-trauma-care-8-week-booster-vaccination-adherence-among-patients-after-trauma-splenectomy
#11
Aaron R Alvarado, Kahdi Udobi, Stepheny Berry, Jaynell Assmann, Tracy McDonald, Robert D Winfield
BACKGROUND: Splenectomies are common after abdominal trauma, and measures must be taken to prevent infection, namely, the administration of available conjugate vaccinations against encapsulated organisms. While initial immunization is frequently completed prior to discharge, the Advisory Council on Immunization Practices recommends administration of an 8-week vaccination booster against S. pneumoniae, and compliance with this practice is unknown. We hypothesized that patients undergoing splenectomy for trauma would not routinely receive the recommended immunization and subsequent booster...
December 1, 2017: Surgery
https://www.readbyqxmd.com/read/29203284/intermediate-term-survival-and-quality-of-life-outcomes-in-patients-with-advanced-colorectal-liver-metastases-undergoing-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#12
Kerollos Nashat Wanis, Victoria Ardiles, Fernando A Alvarez, Mauro Enrique Tun-Abraham, David Linehan, Eduardo de Santibañes, Roberto Hernandez-Alejandro
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an innovative, 2-staged hepatectomy which has elicited controversy within the international hepatobiliary community. Uptake of ALPPS has been limited due to concerns related to evidence of high morbidity and mortality and scant oncologic and quality of life outcome data and quality of life (Ool). Demonstrating reasonable long-term benefits with a short-term risk is necessary to support more widespread endorsement of ALPPS...
December 1, 2017: Surgery
https://www.readbyqxmd.com/read/29199096/sexual-recovery-following-prostate-cancer-recommendations-from-2%C3%A2-established-canadian-sexual-rehabilitation-clinics
#13
REVIEW
Stacy Elliott, Andrew Matthew
INTRODUCTION: Supportive sexual health care is much-needed adjuvant care to oncologic management for men with prostate cancer (PCa). AIM: To inspire the initiation of biopsychosocial sexual health programming where it does not exist and to inform program enhancement in existing sexual rehabilitation clinics (SRCs). METHODS: This article reviews the combined 30-year experience of 2 well-established Canadian SRCs for men and their partners after PCa treatments, interwoven with empirical evidence...
November 30, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29198770/preoperative-enteral-access-is-not-necessary-prior-to-multimodality-treatment-of-esophageal-cancer
#14
Thomas K Jenkins, Alexandra N Lopez, George A Sarosi, Kfir Ben-David, Ryan M Thomas
BACKGROUND: Surgical enteral access prior to multimodality treatment for esophageal cancer is controversial as dysphagia is often used for feeding tube referral. We hypothesized that enteral access before neoadjuvant chemoradiation for esophageal cancer provides no benefit compared to that placed during definitive esophagectomy. METHODS: Patients undergoing esophagectomy for esophageal malignancy from 2007 - 2014 were retrospectively identified. Clinicopathologic factors were recorded including preoperative enteral access, weight change, nutritional laboratory works, and perioperative complications...
November 30, 2017: Surgery
https://www.readbyqxmd.com/read/29198769/subtyping-of-primary-aldosteronism-with-adrenal-vein-sampling-hormone-and-side-specific-effects-of-cosyntropin-and-metoclopramide
#15
Giacomo Rossitto, Giuseppe Maiolino, Livia Lenzini, Valeria Bisogni, Teresa Maria Seccia, Maurizio Cesari, Maurizio Iacobone, Gian Paolo Rossi
BACKGROUND: Cosyntropin and metoclopramide can affect the subtyping of primary aldosteronism when used with adrenal vein sampling by exerting hormone- and side-specific effects on cortisol and aldosterone secretion. We investigated how these stimuli affect the selectivity index, the relative aldosterone secretion index, and the lateralization index in consecutive primary aldosteronism patients submitted to adrenal vein sampling. METHODS: We recruited 171 patients; of these, 149 underwent adrenal vein sampling before and after stimulation with cosyntropin (250 µg intravenous bolus, n= 53, 73% with an aldosterone-producing adenoma) or with metoclopramide (10 mg intravenous bolus, n= 96, 65% aldosterone-producing adenoma), and 32 with an aldosterone-producing adenoma were investigated for the relative gene expression of dopamine, melanocortin 2, and 5-hydroxytryptamine (serotonin) 4 receptor with microarrays...
November 30, 2017: Surgery
https://www.readbyqxmd.com/read/29198748/microparticles-from-stored-red-blood-cells-promote-a-hypercoagulable-state-in-a-murine-model-of-transfusion
#16
Young Kim, Brent T Xia, Andrew D Jung, Alex L Chang, William A Abplanalp, Charles C Caldwell, Michael D Goodman, Timothy A Pritts
BACKGROUND: Red blood cell-derived microparticles are biologically active, submicron vesicles shed by erythrocytes during storage. Recent clinical studies have linked the duration of red blood cell storage with thromboembolic events in critically ill transfusion recipients. In the present study, we hypothesized that microparticles from aged packed red blood cell units promote a hypercoagulable state in a murine model of transfusion. METHODS: Microparticles were isolated from aged, murine packed red blood cell units via serial centrifugation...
November 29, 2017: Surgery
https://www.readbyqxmd.com/read/29198342/management-of-salivary-gland-malignant-tumor-the-policlinico-umberto-i-sapienza-university-of-rome-head-and-neck-unit-clinical-recommendations
#17
REVIEW
Francesca De Felice, Marco de Vincentiis, Valentino Valentini, Daniela Musio, Silvia Mezi, Luigi Lo Mele, Marco Della Monaca, Vittorio D'Aguanno, Valentina Terenzi, Martina Di Brino, Edoardo Brauner, Nadia Bulzonetti, Gianluca Tenore, Giulia Pomati, Andrea Cassoni, Mario Tombolini, Andrea Battisti, Antonio Greco, Giorgio Pompa, Antonio Minni, Umberto Romeo, Enrico Cortesi, Antonella Polimeni, Vincenzo Tombolini
Salivary gland malignant tumor (SGMT) is a malignant disease requiring multidisciplinary approach. The rare incidence and the consequent lack of robust evidence-based medicine has called for a comprehensive update to draw recommendations for clinical practice. This paper is a summary of the XXX Head and Neck Unit guidelines regarding the management of SGMT. Recommendations include the indications for exclusive and adjuvant therapy, as well as metastatic management, for both major and minor SGMT.
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29190078/cu-ii-binding-to-the-peptide-ala-his-his-a-chimera-of-the-canonical-cu-ii-binding-motifs-xxx-his-and-xxx-zzz-his
#18
Paulina Gonzalez, Bertrand Vileno, Karolina Bossak, Youssef El Khoury, Petra Hellwig, Wojciech Bal, Christelle Hureau, Peter Faller
Peptides and proteins with the N-terminal motifs NH2-Xxx-His and NH2-Xxx-Zzz-His form well-established Cu(II) complexes. The canonical peptides are Gly-His-Lys and Asp-Ala-His-Lys (from the wound healing factor and human serum albumin, respectively). Cu(II) is bound to NH2-Xxx-His via three nitrogens from the peptide and an external ligand in the equatorial plane (called 3N form here). In contrast, Cu(II) is bound to NH2-Xxx-Zzz-His via four nitrogens from the peptide in the equatorial plane (called 4N form here)...
November 30, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29189043/an-antarctic-extreme-halophile-and-its-polyextremophilic-enzyme-effects-of-perchlorate-salts
#19
Victoria J Laye, Shiladitya DasSarma
Effects of perchlorate salts prevalent on the surface of Mars are of significant interest to astrobiology from the perspective of potential life on the Red Planet. Halorubrum lacusprofundi, a cold-adapted halophilic Antarctic archaeon, was able to grow anaerobically on 0.04 M concentration of perchlorate. With increasing concentrations of perchlorate, growth was inhibited, with half-maximal growth rate in ca. 0.3 M NaClO4 and 0.1 M Mg(ClO4)2 under aerobic conditions. Magnesium ions were also inhibitory for growth, but at considerably higher concentrations, with half-maximal growth rate above 1 M...
November 30, 2017: Astrobiology
https://www.readbyqxmd.com/read/29189040/organic-haze-as-a-biosignature-in-anoxic-earth-like-atmospheres
#20
Giada Arney, Shawn D Domagal-Goldman, Victoria S Meadows
Early Earth may have hosted a biologically mediated global organic haze during the Archean eon (3.8-2.5 billion years ago). This haze would have significantly impacted multiple aspects of our planet, including its potential for habitability and its spectral appearance. Here, we model worlds with Archean-like levels of carbon dioxide orbiting the ancient Sun and an M4V dwarf (GJ 876) and show that organic haze formation requires methane fluxes consistent with estimated Earth-like biological production rates...
November 30, 2017: Astrobiology
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