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https://www.readbyqxmd.com/read/28723229/the-formation-of-nucleobases-from-the-ultraviolet-photoirradiation-of-purine-in-simple-astrophysical-ice-analogues
#1
Christopher K Materese, Michel Nuevo, Scott A Sandford
Nucleobases are the informational subunits of RNA and DNA and are essential to all known forms of life. The nucleobases can be divided into two groups of molecules: the pyrimidine-based compounds that include uracil, cytosine, and thymine, and the purine-based compounds that include adenine and guanine. Previous work in our laboratory has demonstrated that uracil, cytosine, thymine, and other nonbiological, less common nucleobases can form abiotically from the UV photoirradiation of pyrimidine in simple astrophysical ice analogues containing combinations of H2O, NH3, and CH4...
July 19, 2017: Astrobiology
https://www.readbyqxmd.com/read/28715606/enzymatic-mechanisms-of-biological-magnetic-sensitivity
#2
Ulyana G Letuta, Vitaly L Berdinskiy, Chikako Udagawa, Yoshifumi Tanimoto
Primary biological magnetoreceptors in living organisms is one of the main research problems in magnetobiology. Intracellular enzymatic reactions accompanied by electron transfer have been shown to be receptors of magnetic fields, and spin-dependent ion-radical processes can be a universal mechanism of biological magnetosensitivity. Magnetic interactions in intermediate ion-radical pairs, such as Zeeman and hyperfine (HFI) interactions, in accordance with proposed strict quantum mechanical theory, can determine magnetic-field dependencies of reactions that produce biologically important molecules needed for cell growth...
July 17, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28711404/penile-plication-with-or-without-degloving-of-the-penis-results-in-similar-outcomes
#3
Rustam Kadirov, Burhan Coskun, Onur Kaygisiz, Kadir Omur Gunseren, Yakup Kordan, Ismet Yavascaoglu, Hakan Kilicarslan
BACKGROUND: Penile plication techniques with or without degloving offer a minimally invasive option for the treatment of penile curvature. AIM: To review the outcomes of penile plication surgery and patient satisfaction with and without degloving of the penis. METHODS: We conducted a retrospective analysis of 52 patients who underwent penile plication for the treatment of Peyronie disease or congenital penile curvature. OUTCOMES: Surgical success rates, complications, and patient satisfaction determined with the Treatment Benefit Scale were compared between groups...
July 13, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28711223/role-of-sexuality-in-body-integrity-identity-disorder-biid-a%C3%A2-cross-sectional-internet-based-survey-study
#4
Rianne M Blom, Sija J van der Wal, Nienke C Vulink, Damiaan Denys
BACKGROUND: Body integrity identity disorder (BIID)-a strong desire for amputation or paralysis-is often accompanied by feelings and cognitions of sexual arousal, although this sexual component has been largely neglected in the recent literature. AIM: To examine the presence of BIID-related sexual arousal in subjects with BIID and explore clinical and demographic variables of subjects with BIID who do and do not possess this sexual arousal. METHODS: Eighty individuals with BIID responded to an internet-based survey we created...
July 13, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28709890/a-novel-collaborative-protocol-for-successful-management-of-penile-pain-mediated-by-radiculitis-of-sacral-spinal-nerve-roots-from-tarlov-cysts
#5
Irwin Goldstein, Barry R Komisaruk, Rachel S Rubin, Sue W Goldstein, Stacy Elliott, Jennifer Kissee, Choll W Kim
INTRODUCTION: Since 14 years of age, the patient had experienced extreme penile pain within seconds of initial sexual arousal through masturbation. Penile pain was so severe that he rarely proceeded to orgasm or ejaculation. After 7 years of undergoing multiple unsuccessful treatments, he was concerned for his long-term mental health and for his future ability to have relationships. AIM: To describe a novel collaboration among specialists in sexual medicine, neurophysiology, and spine surgery that led to successful management...
July 12, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28709874/analysis-of-hospital-readmissions-after-prosthetic-urologic-surgery-in-the-united-states-nationally-representative-estimates-of-causes-costs-and-predictive-factors
#6
Filippo Pederzoli, Meera R Chappidi, Sarah Collica, Max Kates, Gregory A Joice, Nikolai A Sopko, Francesco Montorsi, Andrea Salonia, Trinity J Bivalacqua
BACKGROUND: The surgical treatment of urinary incontinence and erectile dysfunction by prosthetic devices has become part of urologic practice, although sparse data exist at a national level on readmissions and hospital costs. AIM: To assess causes and costs of early (≤30 days) and late (31-90 days) readmissions after implantation of penile prostheses (PPs), artificial urinary sphincters (AUSs), or PP + AUS. METHODS: Using the 2013 and 2014 US Nationwide Readmission Databases, sociodemographic characteristics, hospital costs, and causes of readmission were compared among PP, AUS and AUS + PP surgeries...
July 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28708419/mechanisms-of-the-formation-of-adenine-guanine-and-their-analogues-in-uv-irradiated-mixed-nh3-h2o-molecular-ices-containing-purine
#7
Partha P Bera, Tamar Stein, Martin Head-Gordon, Timothy J Lee
We investigated the formation mechanisms of the nucleobases adenine and guanine and the nucleobase analogues hypoxanthine, xanthine, isoguanine, and 2,6-diaminopurine in a UV-irradiated mixed 10:1 H2O:NH3 ice seeded with precursor purine by using ab initio and density functional theory computations. Our quantum chemical investigations suggest that a multistep reaction mechanism involving purine cation, hydroxyl and amino radicals, together with water and ammonia, explains the experimentally obtained products in an independent study...
July 14, 2017: Astrobiology
https://www.readbyqxmd.com/read/28708412/digital-holographic-microscopy-a-method-for-detection-of-microorganisms-in-plume-samples-from-enceladus-and-other-icy-worlds
#8
Manuel Bedrossian, Chris Lindensmith, Jay L Nadeau
Detection of extant microbial life on Earth and elsewhere in the Solar System requires the ability to identify and enumerate micrometer-scale, essentially featureless cells. On Earth, bacteria are usually enumerated by culture plating or epifluorescence microscopy. Culture plates require long incubation times and can only count culturable strains, and epifluorescence microscopy requires extensive staining and concentration of the sample and instrumentation that is not readily miniaturized for space. Digital holographic microscopy (DHM) represents an alternative technique with no moving parts and higher throughput than traditional microscopy, making it potentially useful in space for detection of extant microorganisms provided that sufficient numbers of cells can be collected...
July 14, 2017: Astrobiology
https://www.readbyqxmd.com/read/28704064/nucleic-acid-extraction-from-synthetic-mars-analog-soils-for-in-situ-life-detection
#9
Angel Mojarro, Gary Ruvkun, Maria T Zuber, Christopher E Carr
Biological informational polymers such as nucleic acids have the potential to provide unambiguous evidence of life beyond Earth. To this end, we are developing an automated in situ life-detection instrument that integrates nucleic acid extraction and nanopore sequencing: the Search for Extra-Terrestrial Genomes (SETG) instrument. Our goal is to isolate and determine the sequence of nucleic acids from extant or preserved life on Mars, if, for example, there is common ancestry to life on Mars and Earth. As is true of metagenomic analysis of terrestrial environmental samples, the SETG instrument must isolate nucleic acids from crude samples and then determine the DNA sequence of the unknown nucleic acids...
July 13, 2017: Astrobiology
https://www.readbyqxmd.com/read/28700105/dante-s-inferno-canto-xxx-imaginary-or-real-liver-disease
#10
Luigi Roffi
This image (Figure 1) shows a glimpse of Hell (Divine Comedy), when Dante Alighieri encounters Master Adam (who, having counterfeited the Florentine money, was burned at the stake in Florence in 1281), and Sinon (who tricked the Trojans with the wooden horse filled with Achaean warriors). Master Adam, an Englishman (magistro Adam de Anglia) (1) has the shape of a lute, a rotting face, and an abdomen bloated by a disease called 'dropsy' ("…And one I saw, who like a lute were shaped / if he had only had his groin cut off / down in the region where a man is forked / The heavy dropsy which unmates the limbs / in such a way with ill-digested humor / that face and paunch no longer correspond…/ Divine Comedy, Inferno XXX, 49-54) (2)...
July 12, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28697408/a-finding-in-genetic-polymorphism-analysis-study-a-case-of-non-mosaic-47-xxx-without-manifestations
#11
Xingyi Yang, Zilan Ye, Xiaofang Zhang, Huijun Wang, Chao Liu
Trisomy X (47, XXX) is a sex chromosome aneuploidy condition in which females have an extra X chromosome, compared to the 46, XX karyotype in typical females. There is considerable variation in the phenotype, with some individuals very mildly affected and others with more significant physical and psychological features. However, the trisomy X in this case, without any of these phenotype, is rarely reported. Here, we report a case found during DNA sample collection in a study of genetic polymorphism analysis of loci in Chinese ethnic group, of a female with neither laboratory or clinical signs of Triple X syndrome...
June 30, 2017: Legal Medicine
https://www.readbyqxmd.com/read/28692793/rare-x-chromosome-abnormalities-in-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome
#12
Rohan Sharma, Valerie M Harris, Joshua Cavett, Biji T Kurien, Ke Liu, Kristi A Koelsch, Anum Fayaaz, Kaustubh S Chaudhari, Lida Radfar, David Lewis, Donald U Stone, C Erick Kaufman, Shibo Li, Barbara Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Jennifer A Kelly, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Ilias Alevizos, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gang Xie, Gunnel Nordmark, Sara Magnusson Bucher, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Marie Wahren-Herlenius, Torsten Witte, Marta Alarcon-Riquelme, Xavier Mariette, Christopher J Lessard, John B Harley, Wan-Fai Ng, Astrid Rasmussen, Kathy L Sivils, R Hal Scofield
BACKGROUND: Sjögren's syndrome and systemic lupus erythematosus (SLE) are related by clinical and serological manifestations as well as genetic risks. Both diseases are more commonly found in women compared to men at a ratio of about 10 to 1. Common X chromosome aneuploidies, 47,XXY and 47,XXX, are enriched among men and women, respectively, in either disease suggesting a dose effect on the X chromosome. METHODS: We examined cohorts of Sjögren's syndrome or SLE patients with intensity plots of X chromosome single nucleotide polymorphism (SNP) alleles along with karyotype of selected subjects...
July 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28692303/searching-for-biosignatures-in-exoplanetary-impact-ejecta
#13
Gianni Cataldi, Alexis Brandeker, Philippe Thébault, Kelsi Singer, Engy Ahmed, Bernard L de Vries, Anna Neubeck, Göran Olofsson
With the number of confirmed rocky exoplanets increasing steadily, their characterization and the search for exoplanetary biospheres are becoming increasingly urgent issues in astrobiology. To date, most efforts have concentrated on the study of exoplanetary atmospheres. Instead, we aim to investigate the possibility of characterizing an exoplanet (in terms of habitability, geology, presence of life, etc.) by studying material ejected from the surface during an impact event. For a number of impact scenarios, we estimate the escaping mass and assess its subsequent collisional evolution in a circumstellar orbit, assuming a Sun-like host star...
July 10, 2017: Astrobiology
https://www.readbyqxmd.com/read/28682665/can-life-begin-on-enceladus-a-perspective-from-hydrothermal-chemistry
#14
David Deamer, Bruce Damer
Enceladus is a target of future missions designed to search for existing life or its precursors. Recent flybys of Enceladus by the Cassini probe have confirmed the existence of a long-lived global ocean laced with organic compounds and biologically available nitrogen. This immediately suggests the possibility that life could have begun and may still exist on Enceladus. Here we will compare the properties of two proposed sites for the origin of life on Earth-hydrothermal vents on the ocean floor and hydrothermal volcanic fields at the surface-and ask whether similar conditions could have fostered the origin of life on Enceladus...
July 6, 2017: Astrobiology
https://www.readbyqxmd.com/read/28676223/prevalence-of-peyronie-s-disease-like-symptoms-in-men-presenting-with-dupuytren-contractures
#15
Alan W Shindel, Genevieve Sweet, William Thieu, Blythe Durbin-Johnson, Jennifer Rothschild, Robert Szabo
INTRODUCTION: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism. AIM: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC. METHODS: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. The survey assessed several basic demographic and sexual health factors and included items from the International Index of Erectile Function and the Erection Hardness Scale...
July 1, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28666836/flibanserin-efficacy-and-safety-in-premenopausal-women-with-generalized-acquired-hypoactive-sexual-desire-disorder
#16
REVIEW
William A Fisher, Robert E Pyke
INTRODUCTION: Flibanserin is a postsynaptic 5-HT-1A agonist and 5-HT-2A antagonist for the treatment of generalized acquired hypoactive sexual desire disorder in premenopausal women. AIM: To review and evaluate the efficacy and safety of flibanserin. METHODS: We review and critique the appropriateness of the co-primary and secondary end points used in the flibanserin pivotal trial research program. We review the efficacy and safety parameters of this drug based on the published literature and related sources...
June 27, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28666657/body-esteem-as-a-common-factor-of-a-tendency-toward-binge-eating-and-sexual-dissatisfaction-among-women-the-role-of-dissociation-and-stress-response-during-sex
#17
Giovanni Castellini, Carolina Lo Sauro, Valdo Ricca, Alessandra H Rellini
BACKGROUND: Several studies have suggested a relevant overlap between eating disorders and sexual dysfunction involving the emotional component of body image esteem and dissociative experiences. AIM: To evaluate the common maintaining factors of sexual dysfunction and vulnerability to pathologic eating behaviors and their relation to a physiologic stress response. METHODS: In the present cross-sectional study, we evaluated a non-clinical sample of 60 heterosexual women (25-35 years old) for dissociation during sex with a partner, body image disturbance, and tendency toward pathologic eating behaviors...
June 27, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28666656/reasons-for-and-experiences-with-surgical-interventions-for-female-genital-mutilation-cutting-fgm-c-a-systematic-review
#18
REVIEW
Rigmor C Berg, Sølvi Taraldsen, Maryan A Said, Ingvil Krarup Sørbye, Siri Vangen
BACKGROUND: Because female genital mutilation/cutting (FGM/C) leads to changes in normal genital anatomy and functionality, women are increasingly seeking surgical interventions for their FGM/C-related concerns. AIM: To conduct a systematic review of empirical quantitative and qualitative research on interventions for women with FGM/C-related complications. METHODS: We conducted systematic searches up to May 2016 in 16 databases to obtain references from different disciplines...
June 27, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28665680/detecting-darwinism-from-molecules-in-the-enceladus-plumes-jupiter-s-moons-and-other-planetary-water-lagoons
#19
Steven A Benner
To the astrobiologist, Enceladus offers easy access to a potential subsurface biosphere via the intermediacy of a plume of water emerging directly into space. A direct question follows: If we were to collect a sample of this plume, what in that sample, through its presence or its absence, would suggest the presence and/or absence of life in this exotic locale? This question is, of course, relevant for life detection in any aqueous lagoon that we might be able to sample. This manuscript reviews physical chemical constraints that must be met by a genetic polymer for it to support Darwinism, a process believed to be required for a chemical system to generate properties that we value in biology...
June 30, 2017: Astrobiology
https://www.readbyqxmd.com/read/28647404/patient-centered-outcomes-and-treatment-preferences-regarding-sexual-problems-a-qualitative-study-among-midlife-women
#20
Holly N Thomas, Megan Hamm, Rachel Hess, Sonya Borrero, Rebecca C Thurston
BACKGROUND: Sexual dysfunction is common in midlife women and can have a significant negative impact on quality of life. Although treatments exist, there is little research on which sexual function outcomes and treatments midlife women prefer. AIM: To better understand the sexual function outcomes that were most important to sexually active women 45 to 60 years old and the types of treatments they would prefer from individual interviews and focus groups. METHODS: Twenty individual interviews and three focus groups (N = 39) were led by a trained facilitator, audio recorded, and transcribed...
June 21, 2017: Journal of Sexual Medicine
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