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https://www.readbyqxmd.com/read/28325536/self-reported-neuropathic-pain-characteristics-of-women-with-provoked-vulvar-pain-a-preliminary-investigation
#1
Emma Dargie, Ian Gilron, Caroline F Pukall
BACKGROUND: Provoked vestibulodynia (PVD) is a common chronic genital pain condition affecting approximately 12% of premenopausal women. Although parallels have been drawn between PVD and neuropathic pain (NP), no studies have examined self-reported NP characteristics in PVD. AIM: To explore pain symptoms that resemble NP reported by those with PVD and compare responses with those with an established NP condition. METHODS: Women with provoked vulvar pain (PVP; n = 65) completed online questionnaires designed to assess characteristics of NP...
March 15, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28325535/age-is-just-a-number-wpath-affiliated-surgeons-experiences-and-attitudes-toward-vaginoplasty-in-transgender-females-under-18-years-of-age-in-the-united-states
#2
Christine Milrod, Dan H Karasic
BACKGROUND: A rising number of female-affirmed transgender adolescents are being treated with gonadotropin-releasing hormone analogues and subsequently cross-sex hormones at early or mid-puberty, with vaginoplasty as the presumed final step in their physical transition. But, despite the minimum age of 18 years defining eligibility to undergo this irreversible procedure, anecdotal reports have shown that vaginoplasties are being performed on minors by surgeons in the United States, thereby contravening the World Professional Association for Transgender Health (WPATH) standards of care (SOC)...
March 16, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28323456/stratosphere-conditions-inactivate-bacterial-endospores-from-a-mars-spacecraft-assembly-facility
#3
Christina L Khodadad, Gregory M Wong, Leandro M James, Prital J Thakrar, Michael A Lane, John A Catechis, David J Smith
Every spacecraft sent to Mars is allowed to land viable microbial bioburden, including hardy endospore-forming bacteria resistant to environmental extremes. Earth's stratosphere is severely cold, dry, irradiated, and oligotrophic; it can be used as a stand-in location for predicting how stowaway microbes might respond to the martian surface. We launched E-MIST, a high-altitude NASA balloon payload on 10 October 2015 carrying known quantities of viable Bacillus pumilus SAFR-032 (4.07 × 10(7) spores per sample), a radiation-tolerant strain collected from a spacecraft assembly facility...
March 21, 2017: Astrobiology
https://www.readbyqxmd.com/read/28316320/critical-flicker-frequency-test-for-diagnosing-minimal-hepatic-encephalopathy-in-patients-with-cirrhosis
#4
Banu Demet Özel Coşkun, Mustafa Özen
BACKGROUND/AIMS: The critical flicker frequency (CFF) and psychometric hepatic encephalopathy score (PHES) are commonly proposed tests for detecting minimal hepatic encephalopathy (MHE); however, no studies have examined their value for detecting MHE in Turkey. MATERIALS AND METHODS: A total of 70 patients with cirrhosis without overt HE, 205 controls for PHES, and 100 controls for the CFF test were included. All the patients underwent the PHES and CFF tests during the same session...
March 17, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28282220/identification-and-characterization-of-early-mission-phase-microorganisms-residing-on-the-mars-science-laboratory-and-assessment-of-their-potential-to-survive-mars-like-conditions
#5
Stephanie A Smith, James N Benardini, David Anderl, Matt Ford, Emmaleen Wear, Michael Schrader, Wayne Schubert, Linda DeVeaux, Andrzej Paszczynski, Susan E Childers
Planetary protection is governed by the Outer Space Treaty and includes the practice of protecting planetary bodies from contamination by Earth life. Although studies are constantly expanding our knowledge about life in extreme environments, it is still unclear what the probability is for terrestrial organisms to survive and grow on Mars. Having this knowledge is paramount to addressing whether microorganisms transported from Earth could negatively impact future space exploration. The objectives of this study were to identify cultivable microorganisms collected from the surface of the Mars Science Laboratory, to distinguish which of the cultivable microorganisms can utilize energy sources potentially available on Mars, and to determine the survival of the cultivable microorganisms upon exposure to physiological stresses present on the martian surface...
March 2017: Astrobiology
https://www.readbyqxmd.com/read/28282216/remote-sensing-of-potential-biosignatures-from-rocky-liquid-or-icy-exo-planetary-surfaces
#6
Olivier Poch, Joachim Frey, Isabel Roditi, Antoine Pommerol, Bernhard Jost, Nicolas Thomas
To detect signs of life by remote sensing on objects of our Solar System and on exoplanets, the characterization of light scattered by surface life material could complement possible clues given by the atmospheric composition. We reviewed the reflectance spectra of a broad selection of major biomolecules that constitute terrestrial carbon-based life from 0.4 to 2.4 μm, and we discuss their detectability through atmospheric spectral windows. Biomolecule features in the near-infrared (0.8-2.4 μm) will likely be obscured by water spectral features and some atmospheric gases...
March 2017: Astrobiology
https://www.readbyqxmd.com/read/28277783/origin-of-life-and-the-phosphate-transfer-catalyst
#7
Radosław W Piast, Rafał M Wieczorek
In this paper, we revisit several issues relevant to origin-of-life research and propose a Phosphate Transfer Catalyst hypothesis that furthers our understanding of some of the key events in prebiotic chemical evolution. In the Phosphate Transfer Catalyst hypothesis, we assume the existence of hypothetical metallopeptides with phosphate transfer activity that use abundant polyphosphates as both substrates and energy sources. Nonspecific catalysis by this phosphate transfer catalyst would provide a variety of different products such as phosphoryl amino acids, nucleosides, polyphosphate nucleotides, nucleic acids, and aminoacylated nucleic acids...
March 2017: Astrobiology
https://www.readbyqxmd.com/read/28275072/strategies-for-optimizing-the-diagnostic-predictive-value-of-clostridium-difficile-molecular-diagnostics
#8
Larry K Kociolek
Because nucleic acid amplification tests (NAATs) do not distinguish Clostridium difficile infection (CDI) and asymptomatic C. difficile carriage, the diagnostic predictive value of NAATs is limited when used in patients with low probability of CDI. In this issue of the Journal of Clinical Microbiology, Truong et al. report significant reductions in hospital-onset CDI and oral vancomycin utilization at their institution following implementation of a novel intervention that leveraged their clinical bioinformatics resources to prevent C...
March 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28268155/functional-variations-in-the-nos3-gene-are-associated-with-erectile-dysfunction-susceptibility-age-of-onset-and-severity-in-a-han-chinese-population
#9
Bo Yang, Liangren Liu, Zhufeng Peng, Dongliang Lu, Zhengju Ren, Shengzuo Liu, Xiling Yang, Jian Liao, Qiang Dong
BACKGROUND: Impaired function of endothelial nitric oxide synthase (eNOS) is involved in the pathologic processes of erectile dysfunction (ED), and three functional polymorphisms (G894T, T-786C, and a tandem repeat of 27 bp in intron 4) in the NOS3 gene, which encodes eNOS, are associated with the clinical characteristics of ED in several populations. AIM: To investigate the effect of these variations of NOS3 on ED phenotypes and the response to sildenafil in a Han Chinese population...
March 4, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28263676/survival-and-dna-damage-in-plant-seeds-exposed-for-558-and-682-days-outside-the-international-space-station
#10
David Tepfer, Sydney Leach
For life to survive outside the biosphere, it must be protected from UV light and other radiation by exterior shielding or through sufficient inherent resistance to survive without protection. We tested the plausibility of inherent resistance in plant seeds, reporting in a previous paper that Arabidopsis thaliana and tobacco (Nicotiana tabacum) seeds exposed for 558 days outside the International Space Station (ISS) germinated and developed into fertile plants after return to Earth. We have now measured structural genetic damage in tobacco seeds from this EXPOSE-E experiment by quantitatively amplifying a segment of an antibiotic resistance gene, nptII, inserted into the chloroplast genome...
March 2017: Astrobiology
https://www.readbyqxmd.com/read/28259502/development-and-initial-validation-of-the-beliefs-about-sexual-functioning-scale-a-gender-invariant-measure
#11
Patrícia M Pascoal, Maria-João Alvarez, Cicero Roberto Pereira, Pedro Nobre
BACKGROUND: Past research on cognitive models of sexual functioning has focused on sexual beliefs as an important vulnerability factor for sexual dysfunction. However, the existing measurements of sexual beliefs are lengthy and entangle beliefs about sexual functioning with moral beliefs and ideas about sexuality. Furthermore, they have female and male versions, which does not allow for sex comparisons or dyadic research with heterosexual couples. AIM: To describe the development and validation of the Beliefs About Sexual Functioning Scale (BASEF), which assesses beliefs about sexual functioning in men and women...
March 1, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28258955/inhibition-of-cyclic-gmp-export-by-multidrug-resistance-protein-4-a-new-strategy-to-treat-erectile-dysfunction
#12
Charlotte Boydens, Bart Pauwels, Laura Vanden Daele, Johan Van de Voorde
BACKGROUND: Intracellular cyclic guanosine monophosphate (cGMP) concentrations are regulated by degradation enzymes (phosphodiesterases) and by active transport across the plasma membrane by multidrug resistance proteins (MRPs) 4 and 5. AIM: To evaluate the functional effect of MRP-4 inhibition and the role of MRP-4-mediated cGMP export in mouse corpora cavernosa. METHODS: Isometric tension of mouse corpora cavernosa was measured after cumulative addition of MK-571, an inhibitor of MRP-4, or sildenafil, a phosphodiesterase type 5 inhibitor...
February 28, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28258954/prevalence-and-predicting-factors-for-commonly-neglected-sexual-side-effects-to-external-beam-radiation-therapy-for-prostate-cancer
#13
Anders Frey, Christian Pedersen, Henriette Lindberg, Rasmus Bisbjerg, Jens Sønksen, Mikkel Fode
INTRODUCTION: Changes in sexual function other than erectile dysfunction are sparsely investigated after radiation therapy for prostate cancer. AIM: To investigate orgasmic dysfunction, urinary incontinence during sexual activity, changes in penile morphology, and sensory disturbances in the penis in patients with prostate cancer treated with external-beam radiation therapy (EBRT). METHODS: In February 2015, men treated with EBRT at our center 3 months to 5 years previously (N = 519) received a study-specific questionnaire...
February 28, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28258953/sexual-pleasure-and-function-coital-trauma-and-sex-behaviors-after-voluntary-medical-male-circumcision-among-men-in-the-dominican-republic
#14
Maximo O Brito, Shaveta Khosla, Sheewin Pananookooln, Paul J Fleming, Leonel Lerebours, Yeycy Donastorg, Robert C Bailey
BACKGROUND: Voluntary medical male circumcision (VMMC) is effective in decreasing the risk of HIV acquisition. As men resume sexual activity after circumcision, it will be important to study their satisfaction with the procedure, sexual pleasure and function, coital trauma, and risk compensation (RC), which can hamper or facilitate the long-term success of VMMC programs. AIM: To assess men's satisfaction with VMMC, sexual pleasure and function, coital trauma, and RC after VMMC...
March 1, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28258952/in-situ-activation-of-penile-progenitor-cells-with-low-intensity-extracorporeal-shockwave-therapy
#15
Guiting Lin, Amanda B Reed-Maldonado, Bohan Wang, Yung-Chin Lee, Jun Zhou, Zhihua Lu, Guifang Wang, Lia Banie, Tom F Lue
BACKGROUND: We previously reported that progenitor cells, or stem cells, exist within penile tissue. We hypothesized that acoustic wave stimulation by low-intensity extracorporeal shockwave therapy (Li-ESWT) would activate local stem or progenitor cells within the penis, producing regenerative effects. AIMS: To study the feasibility of in situ penile progenitor cell activation by Li-ESWT. METHODS: We performed a cohort analysis of young and middle-age male Sprague-Dawley rats treated with 5-ethynyl-2'-deoxyuridine (EdU) pulse followed by Li-ESWT...
February 28, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28254671/are-patient-reported-outcomes-predictive-of-patient-satisfaction-five-years-after-anterior-cervical-spine-surgery
#16
Gregory D Schroeder, Dom Coric, Han Jo Kim, Todd J Albert, Kris E Radcliff
BACKGROUND CONTEXT: Patient satisfaction is becoming an increasing common proxy for surgical quality; however, the correlation between patient satisfaction and surgical outcomes two and five years after anterior cervical surgery has not been evaluated. PURPOSE: To determine if patient satisfaction is predicted by improvement in patient reported outcomes (PRO) two and five years after anterior cervical spine surgery. STUDY DESIGN: A retrospective analysis of prospectively collected data...
February 27, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28253407/culturally-responsive-pain-management-for-black-older-adults
#17
Sheria G Robinson-Lane, Staja Q Booker
HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS XX contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo...
March 2, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28242178/biofilm-and-infectious-agents-present-at-the-time-of-penile-prosthesis-revision-surgery-times-are-a-changing
#18
REVIEW
Lauren E Dawn, Gerard D Henry, Gary K Tan, Steven K Wilson
INTRODUCTION: Although infection rates have decreased with the use of antibiotic-coated implants and other enhancements, the risk of infection is still considered a serious concern in penile implant revision surgeries. AIM: To review the literature for advances made in inflatable penile prosthesis (IPP) revision surgery and organisms found at the time of revision, the significance of biofilm in prosthetic infection, and the bacteriology of infection. METHODS: PubMed was reviewed for articles spanning the past three decades that discussed micro-organisms and biofilm in relation to penile implant revision surgery...
February 24, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28238684/-macho-beliefs-moderate-the-association-between-negative-sexual-episodes-and-activation-of-incompetence-schemas-in-sexual-context-in-gay-and-heterosexual-men
#19
Maria Manuela Peixoto, Pedro Nobre
BACKGROUND: Despite the existence of conceptual models of sexual dysfunction based on cognitive theory, few studies have tested the role of vulnerability factors such as sexual beliefs as moderators of the activation of cognitive schemas in response to negative sexual events. AIM: To test the moderator role of dysfunctional sexual beliefs in the association between the frequency of negative sexual episodes and the activation of incompetence schemas in gay and heterosexual men...
February 23, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28238679/how-does-paying-attention-improve-sexual-functioning-in-women-a%C3%A2-review-of-mechanisms
#20
REVIEW
Nikita Arora, Lori A Brotto
INTRODUCTION: Female sexual dysfunction (FSD), consisting of a constellation of distressing sexual symptoms, is highly prevalent worldwide. Given the central role played by psychological factors in the development of FSD, psychologically and in particular mindfulness-based interventions have arisen as potential treatment options for women. Although mindfulness-based interventions have been evaluated in samples of women with gynecologic cancer; a history of sexual abuse; multiple sclerosis; and spinal cord injury; and provoked vestibulodynia, the mechanisms by which mindfulness leads to improvements in sexual functioning are largely unstudied...
February 23, 2017: Sexual Medicine Reviews
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