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https://www.readbyqxmd.com/read/29679497/ewsr1-patz1-gene-fusion-may-define-a-new-glioneuronal-tumor-entity
#1
Aurore Siegfried, Audrey Rousseau, Claude-Alain Maurage, Sarah Pericart, Yvan Nicaise, Frederic Escudie, David Grand, Alix Delrieu, Anne Gomez-Brouchet, Sophie Le Guellec, Camille Franchet, Sergio Boetto, Matthieu Vinchon, Jean-Christophe Sol, Franck-Emmanuel Roux, Valerie Rigau, Anne-Isabelle Bertozzi, David Tw Jones, Dominique Figarella-Branger, Emmanuelle Uro-Coste
We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fusion panel. We did not retrieve the SLC44A1-PRKCA fusion gene specific for papillary glioneuronal tumor, but an EWSR1-PATZ1 fusion transcript. RT-PCR followed by Sanger sequencing confirmed the EWSR1-PATZ1 fusion. It matched with canonic EWSR1 fusion oncogene, juxtaposing the entire N terminal transcriptional activation domain of EWSR1 gene and the C terminal DNA binding domain of a transcription factor gene, PATZ1...
April 21, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29615466/lmx1a-is-required-for-the-development-of-the-ovarian-stem-cell-niche-in-drosophila
#2
Andrew W Allbee, Diego E Rincon-Limas, Benoît Biteau
The Drosophila ovary serves as a model for pioneering studies of stem cell niches, with defined cell types and signaling pathways supporting both germline and somatic stem cells. The establishment of the niche units begins during larval stages with the formation of terminal filament-cap structures; however, the genetics underlying their development remains largely unknown. Here we show that the transcription factor Lmx1a is required for ovary morphogenesis. We found that Lmx1a is expressed in early ovarian somatic lineages and becomes progressively restricted to terminal filaments and cap cells...
April 3, 2018: Development
https://www.readbyqxmd.com/read/29604198/evaluation-of-breath-alcohol-analysers-by-comparison-of-breath-and-blood-alcohol-concentrations
#3
Andreja Jurič, Andrija Fijačko, Lana Bakulić, Tanja Orešić, Ines Gmajnički
The main goal of this study was to determine the reliability of hand-held breath alcohol analysers currently approved for roadside screening of traffic offenders. The first part of the study included a retrospective data analysis of 714 offence records collected in 2011. Blood alcohol concentrations (BAC) obtained from the offenders 0-303 min after the police had screened them for breath alcohol concentration (BrAC) were back-calculated (cBAC) to assess the accuracy of breathalyser screening. All participants were in the alcohol elimination phase, and our analyses did not reveal any significant differences between cBAC and BrAC...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29597305/effects-of-consuming-a-low-dose-of-alcohol-with-mixers-containing-carbohydrate-or-artificial-sweetener-on-simulated-driving-performance
#4
Bryce Brickley, Ben Desbrow, Danielle McCartney, Christopher Irwin
The Australian National Drug and Alcohol Research Centre (NDARC) devised gender-based drinking recommendations to ensure blood or equivalized breath alcohol concentrations (BrAC) remain <0.050%. However, these may be inappropriate for individuals consuming alcohol without carbohydrate (CHO), which results in higher BrACs. This study investigated the effects of ingesting alcohol with and without CHO on BrACs and simulated driving performance. Thirty-two participants (16 males; age: 23 ± 6 years) completed two randomized single-blinded trials...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29590325/real-time-monitoring-using-a-breathalyzer-based-ehealth-system-can-identify-lapse-relapse-patterns-in-alcohol-use-disorder-patients
#5
Markku D Hämäläinen, Andreas Zetterström, Maria Winkvist, Marcus Söderquist, Elin Karlberg, Patrik Öhagen, Karl Andersson, Fred Nyberg
Aim: We introduce a new remote real-time breathalyzer-based method for monitoring and early identification of lapse/relapse patterns for alcohol use disorder (AUD) patients using a composite measure of sobriety, the Addiction Monitoring Index (AMI). Methods: We constructed AMI from (a) obtained test results and (b) the pattern of ignored tests using data from the first 30 patients starting in the treatment arms of two on-going clinical trials. The patients performed 2-4 scheduled breath alcohol content (BrAC)-tests per day presented as blood alcohol content (BAC) data...
March 24, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29529253/the-critical-role-of-bach2-in-regulating-type-2-chronic-airway-inflammation
#6
Masakatsu Yamashita, Makoto Kuwahara
Although Bach2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) plays an important role in regulating Th2 cell differentiation and type-2 immune responses, the underlying molecular mechanisms remain unclear. Our current studies demonstrate that Bach2 associates with Batf (basic leucine zipper transcription factor ATF-like) family transcription factors and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2-Batf complex antagonizes the recruitment of the interferon regulatory factor 4 (Irf4)-containing Batf complex to activator protein 1 (AP-1) motifs in the Th2 cytokine gene locus and suppresses Th2 cytokine production and/or Th2 cell differentiation...
February 24, 2018: International Immunology
https://www.readbyqxmd.com/read/29510164/an-ns1abp-like-gene-promotes-white-spot-syndrome-virus-infection-by-interacting-with-the-viral-envelope-protein-vp28-in-red-claw-crayfish-cherax-quadricarinatus
#7
Xiao-Lu Xie, Xue-Jiao Chang, Yan Gao, Dong-Li Li, Ling-Ke Liu, Man-Jun Liu, Ke-Jian Wang, Hai-Peng Liu
Influenza A virus non-structural-1A binding protein (named as Ns1abp) was originally identified as a host protein from human that bound to the viral NS-1 protein. In our previous study, the expression of an Ns1abp-like gene (denoted as CqNs1abp-like gene) was found to be up-regulated in a transcriptome library from the haematopoietic tissue (Hpt) cells of red claw crayfish Cherax quadricarinatus post white spot syndrome virus (WSSV) infection. To elucidate the role of CqNs1abp-like gene involved in WSSV infection, we cloned the CqNs1abp-like gene in which the open reading frame was 2232 bp, encoding 743 amino acids with two typical domains of one BTB (Broad-Complex, Tramtrack and Bric a brac) domain at N-terminal and six Kelch domains at C-terminal...
March 3, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29500954/alcohol-metabolism-in-hangover-sensitive-versus-hangover-resistant-social-drinkers
#8
M Mackus, M van Schrojenstein Lantman, A J A E Van de Loo, A D Kraneveld, J Garssen, K A Brookhuis, J C Verster
BACKGROUND: Previous research demonstrated that urinary ethanol concentrations were significantly lower in hangover resistant individuals compared to drinkers who reported having a hangover. This finding suggests that the rate of ethanol metabolism is faster in drinkers who do not experience an alcohol hangover. This study aimed to directly compare alcohol metabolism after administering a low dose of ethanol to hangover sensitive drinkers and hangover resistant drinkers. METHODS: Social drinkers who previously participated in hangover trials at Utrecht University were invited to participate...
February 21, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29453202/management-of-endocrine-disease-hyperandrogenic-states-in-women-pitfalls-in-laboratory-diagnosis
#9
REVIEW
Michel Pugeat, Ingrid Plotton, Aude Brac de la Perrière, Gérald Raverot, Henri Déchaud, Véronique Raverot
Measuring total testosterone level is the first-line approach in assessing androgen excess in women. The main pitfalls in measuring testosterone relate to its low concentration and to the structural similarity between circulating androgens and testosterone, requiring accurate techniques with high specificity and sensitivity. These goals can be achieved by immunoassay using a specific anti-testosterone monoclonal antibody, ideally after an extraction step. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) will be commonly used for measuring testosterone, providing optimal accuracy with a low limit of detection...
April 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29392372/inhibiting-automatic-negative-social-responses-in-alcohol-intoxication-interactions-with-theory-of-mind-ability-and-level-of-task-guidance
#10
Emma G Johnson, Sarah Skromanis, Raimondo Bruno, Jonathan Mond, Cynthia A Honan
RATIONALE: Alcohol intoxication is associated with socially disinhibited behaviours that may reflect impaired social cognitive abilities that guide social behaviour. The effects of alcohol on social cognition and how this may contribute to disinhibited behaviour are poorly understood. The aim of this study was to examine whether intoxicated individuals could inhibit automatic negative responses to negative social information, whether these difficulties were reliant on theory of mind (ToM) ability and whether intoxicated individuals were able to adjust verbal responses when provided with guidelines about how to respond...
February 1, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29337586/differential-development-of-acute-tolerance-may-explain-heightened-rates-of-impaired-driving-after-consumption-of-alcohol-mixed-with-energy-drinks-versus-alcohol-alone
#11
Cecile A Marczinski, Amy L Stamates, Sarah F Maloney
Consumers of alcohol mixed with energy drinks (AmED) are more likely to drive while impaired when compared to alcohol alone consumers. In addition, acute tolerance to the internal cues of feelings of intoxication is known to contribute to maladaptive decisions to drive while impaired. Therefore, the purpose of this study was to determine whether there is differential development of acute tolerance for AmED versus alcohol alone for ratings of willingness to drive after alcohol consumption. Social drinkers (n = 12) attended 4 separate sessions where they received alcohol and energy drinks, alone and in combination...
April 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29329406/judgement-of-breath-alcohol-concentration-levels-among-pedestrians-in-the-night-time-economy-a-street-intercept-field-study
#12
M P Cameron, M J Roskruge, N Droste, P G Miller
Aims: To evaluate how well people in the night-time economy can assess their own breath alcohol concentration (BrAC), in the context of a change in breath alcohol limits for driving. Methods: We conducted a field study of 242 participants over 5 nights in the central business district of a university town in New Zealand. Participants completed a short survey, which included questions on their self-reported level of intoxication and the self-estimated BrAC. At the conclusion of the interview each participant was breath-tested...
January 10, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29323932/the-effects-of-breath-alcohol-concentration-on-postural-control
#13
Dary D Fiorentino
BACKGROUND: Two of the 3 standardized field sobriety tests that U.S. law enforcement uses at roadside checks have a postural equilibrium component to them. Those tests have been validated to detect impairment caused by blood alcohol concentrations (BACs) of 0.08 g/dL or above. Many medical and traffic safety associations support a lower limit, and one state, Utah, has passed a law to lower the limit to 0.05 g/dL. Many studies have examined the effects of alcohol on postural control (of which postural equilibrium is a component), with a consensus emerging that impairment is usually found at BACs greater than 0...
January 11, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29297463/cis-regulatory-evolution-integrated-the-bric-%C3%A3-brac-transcription-factors-into-a-novel-fruit-fly-gene-regulatory-network
#14
Maxwell J Roeske, Eric M Camino, Sumant Grover, Mark Rebeiz, Thomas Michael Williams
Gene expression evolution through gene regulatory network (GRN) changes has gained appreciation as a driver of morphological evolution. However, understanding how GRNs evolve is hampered by finding relevant cis -regulatory element (CRE) mutations, and interpreting the protein-DNA interactions they alter. We investigated evolutionary changes in the duplicated Bric-à-brac (Bab) transcription factors and a key Bab target gene in a GRN underlying the novel dimorphic pigmentation of D. melanogaster and its relatives...
January 3, 2018: ELife
https://www.readbyqxmd.com/read/29281165/an-intercept-study-to-measure-the-extent-to-which-new-zealand-university-students-pre-game
#15
Benjamin C Riordan, Tamlin S Conner, Jayde A M Flett, Nic Droste, Louise Cody, Kate L Brookie, Jessica K Riordan, Damian Scarf
OBJECTIVE: We aimed to quantify the degree to which students pre-gamed in New Zealand, using self-report and breathalysers. METHODS: A total of 569 New Zealand undergraduate students were interviewed (men = 45.2%; first year = 81.4%) entering three university-run concerts. We asked participants to report how many drinks they had consumed, their self-reported intoxication and the duration of their pre-gaming session. We then recorded participants' Breath Alcohol Concentration (BrAC; µg/L) and the time they arrived at the event...
February 2018: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29277283/correlation-between-blood-alcohol-concentration-bac-breath-alcohol-concentration-brac-and-psychomotor-evaluation-in-a-clinical-monitored-study-of-alcohol-intake-in-brazil
#16
Ana Paula Drummond-Lage, Rodrigo Gomes de Freitas, Gabriel Cruz, Luigi Perillo, Marco Antonio Paiva, Alberto Julius Alves Wainstein
BACKGROUND: Policies that establish maximum blood alcohol concentrations (BACs) or breath alcohol concentration (BrACs) for drivers while driving can reduce traffic accidents by approximately 20%. In Brazil, the National Transit Council (CONTRAN) considers positive BAC and/or BrAC tests or signs of psychomotor capacity alterations as evaluated by a police authority to be an administrative infraction or even a crime. The observed clinical symptoms of alcohol intoxication based on a subject's appearance may not necessarily reflect the quantified BAC and/or BrAC...
February 2018: Alcohol
https://www.readbyqxmd.com/read/29237697/triple-a-syndrome-a-wide-spectrum-of-adrenal-dysfunction
#17
Florence Roucher-Boulez, Aude Brac de la Perriere, Aude Jacquez, Delphine Chau, Laurence Guignat, Christophe Vial, Yves Morel, Marc Nicolino, Gerald Raverot, Michel Pugeat
OBJECTIVE: Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the AAAS gene, which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: alacrima, achalasia and adrenal insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients. METHODS: A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center...
March 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29233567/obtaining-continuous-brac-bac-estimates-in-the-field-a-hybrid-system-integrating-transdermal-alcohol-biosensor-intellidrink-smartphone-app-and-brac-estimator-software-tools
#18
Susan E Luczak, Ashley L Hawkins, Zheng Dai, Raphael Wichmann, Chunming Wang, I Gary Rosen
Biosensors have been developed to measure transdermal alcohol concentration (TAC), but converting TAC into interpretable indices of blood/breath alcohol concentration (BAC/BrAC) is difficult because of variations that occur in TAC across individuals, drinking episodes, and devices. We have developed mathematical models and the BrAC Estimator software for calibrating and inverting TAC into quantifiable BrAC estimates (eBrAC). The calibration protocol to determine the individualized parameters for a specific individual wearing a specific device requires a drinking session in which BrAC and TAC measurements are obtained simultaneously...
December 2, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29227240/pre-drinking-and-the-temporal-gradient-of-intoxication-in-a-new-zealand-nightlife-environment
#19
Michael P Cameron, Matthew J Roskruge, Nic Droste, Peter G Miller
OBJECTIVE: We measured changes in the average level of intoxication over time in the nighttime economy and identified the factors associated with intoxication, including pre-drinking. METHOD: A random intercept sample of 320 pedestrians (105 women; 215 men) was interviewed and received breath alcohol analysis in the nighttime economy of Hamilton, New Zealand. Data were collected over a five-night period, between 7 P.M. and 2:30 A.M. Data were analyzed by plotting the moving average breath alcohol concentration (BrAC) over time and using linear regression models to identify the factors associated with BrAC...
January 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29214468/effects-of-acute-alcohol-and-driving-complexity-in-older-and-younger-adults
#20
Julianne L Price, Ben Lewis, Jeff Boissoneault, Ian R Frazier, Sara Jo Nixon
RATIONALE: Our previous work demonstrated differential neurobehavioral effects of low-dose alcohol consumption on older and younger adults in a driving simulator. However, the ability to enhance or suppress a response in such context has yet to be examined. OBJECTIVES: The current study contrasted older and younger drivers' responses to specific stimuli (i.e., relevant, irrelevant) in scenarios of differing complexity following low-dose acute alcohol administration...
March 2018: Psychopharmacology
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