keyword
MENU ▼
Read by QxMD icon Read
search

BRAC

keyword
https://www.readbyqxmd.com/read/29237697/triple-a-syndrome-a-wide-spectrum-of-adrenal-dysfunction
#1
Florence Roucher-Boulez, Aude Brac de la Perrière, Aude Jacquez, Delphine Chau, Laurence Guignat, Christophe Vial, Yves Morel, Marc Nicolino, Gerald Raverot, Michel Pugeat
Objective: Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the AAAS gene which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: Alacrima, Achalasia and Adrenal Insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients. Methods: A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center...
December 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29233567/obtaining-continuous-brac-bac-estimates-in-the-field-a-hybrid-system-integrating-transdermal-alcohol-biosensor-intellidrink-smartphone-app-and-brac-estimator-software-tools
#2
Susan E Luczak, Ashley L Hawkins, Zheng Dai, Raphael Wichmann, Chunming Wang, I Gary Rosen
Biosensors have been developed to measure transdermal alcohol concentration (TAC), but converting TAC into interpretable indices of blood/breath alcohol concentration (BAC/BrAC) is difficult because of variations that occur in TAC across individuals, drinking episodes, and devices. We have developed mathematical models and the BrAC Estimator software for calibrating and inverting TAC into quantifiable BrAC estimates (eBrAC). The calibration protocol to determine the individualized parameters for a specific individual wearing a specific device requires a drinking session in which BrAC and TAC measurements are obtained simultaneously...
December 2, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29227240/pre-drinking-and-the-temporal-gradient-of-intoxication-in-a-new-zealand-nightlife-environment
#3
Michael P Cameron, Matthew J Roskruge, Nic Droste, Peter G Miller
OBJECTIVE: We measured changes in the average level of intoxication over time in the nighttime economy and identified the factors associated with intoxication, including pre-drinking. METHOD: A random intercept sample of 320 pedestrians (105 women; 215 men) was interviewed and received breath alcohol analysis in the nighttime economy of Hamilton, New Zealand. Data were collected over a five-night period, between 7 P.M. and 2:30 A.M. Data were analyzed by plotting the moving average breath alcohol concentration (BrAC) over time and using linear regression models to identify the factors associated with BrAC...
January 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29214468/effects-of-acute-alcohol-and-driving-complexity-in-older-and-younger-adults
#4
Julianne L Price, Ben Lewis, Jeff Boissoneault, Ian R Frazier, Sara Jo Nixon
RATIONALE: Our previous work demonstrated differential neurobehavioral effects of low-dose alcohol consumption on older and younger adults in a driving simulator. However, the ability to enhance or suppress a response in such context has yet to be examined. OBJECTIVES: The current study contrasted older and younger drivers' responses to specific stimuli (i.e., relevant, irrelevant) in scenarios of differing complexity following low-dose acute alcohol administration...
December 6, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29176950/cardiovascular-and-cutaneous-responses-to-the-combination-of-alcohol-and-soft-drinks-the-way-to-orthostatic-intolerance
#5
Claire Maufrais, Nathalie Charriere, Jean-Pierre Montani
Aim: Acute ingestion of alcohol is often accompanied by cardiovascular dysregulation, malaise and even syncope. The full hemodynamic and cutaneous responses to the combination of alcohol and sugar (i.e., alcopops), a common combination in young people, and the mechanisms for the propensity to orthostatic intolerance are not well established. Thus, the purpose of this study was to evaluate the cardiovascular and cutaneous responses to alcopops in young subjects. Methods: Cardiovascular and cutaneous responses were assessed in 24 healthy young subjects (12 men, 12 women) sitting comfortably and during prolonged active standing with a 30-min baseline and 130 min following ingestion of 400 mL of either: water, water + 48 g sugar, water + vodka (1...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29149458/hormone-therapy-and-patients-satisfaction-with-treatment-in-a-large-cohort-of-diverse-disorders-of-sex-development-dsd
#6
Anna Nordenström, Robert Röhle, Ute Thyen, Claire Bouvattier, Jolanta Slowikowska-Hilczer, Nicole Reisch, Hedi Claahsen van der Grinten, Aude Brac de la Perriere, Peggy T Cohen-Kettenis, Birgit Köhler
OBJECTIVES: To describe and investigate the hormone treatments in individuals with different forms of disorders of sex development (DSD), and the patients own views on their treatment. DESIGN: Multicentre cross-sectional clinical evaluation, dsd-LIFE in six European countries from 02/2014 to 09/2015. PARTICIPANTS: 1040 adolescents and adults (≥16 years) with different DSD conditions. MAIN OUTCOMES MEASURES: Hormone replacement, information received and patient satisfaction...
November 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29143202/tobacco-plants-expressing-the-maize-nitrate-transporter-zmnrt2-1-exhibit-altered-responses-of-growth-and-gene-expression-to-nitrate-and-calcium
#7
Abubakar Ibrahim, Xiao-Lu Jin, Yu-Bin Zhang, Jessica Cruz, Paveena Vichyavichien, Nwadiuto Esiobu, Xing-Hai Zhang
BACKGROUND: Nitrate uptake is a highly regulated process. Understanding the intricate interactions between nitrate availability and genetically-controlled nitrate acquisition and metabolism is essential for improving nitrogen use efficiency and increasing nitrate uptake capacity for plants grown in both nitrate-poor and nitrate-enriched environments. In this report, we introduced into tobacco (Nicotiana tabacum) the constitutively expressed maize high-affinity transporter ZmNrt2.1 gene that would bypass the tight control for the endogenous nitrate-responsive genes...
November 15, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29074243/assessing-the-environmental-quality-of-sediments-from-split-coastal-area-croatia-with-a-battery-of-cell-based-bioassays
#8
Maria Blanco, Elisabet Pérez-Albaladejo, Benjamí Piña, Grozdan Kušpilić, Vesna Milun, Roger Lille-Langøy, Odd André Karlsen, Anders Goksøyr, Cinta Porte
A battery of cell-based bioassays, including PLHC-1 cells, zebrafish-Pxr-transfected COS-7 cells and estrogen receptor-recombinant yeast assay (ER-RYA), were applied to detect the presence of bioactive pollutants in sediments collected from Kaštela Bay and Brač Channel (Croatia). Exposure of PLHC-1 cells to the sediment extracts evidenced significant cytotoxicity and presence of CYP1A inducers in sediments collected in Kaštela Bay, near the industrial zone and cargo port of Split. Sediments from this area, which is highly contaminated with PCBs, HCB, DDTs and γ-HCH, also activated the zebrafish Pxr (zfPxr) reporter system...
October 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29039492/black-rice-derived-anthocyanins-inhibit-her-2-positive-breast-cancer-epithelial-mesenchymal-transition-mediated-metastasis-in%C3%A2-vitro-by-suppressing-fak-signaling
#9
Jie Zhou, Yan-Feng Zhu, Xiang-Yan Chen, Bin Han, Fei Li, Jing-Yao Chen, Xiao-Li Peng, Li-Ping Luo, Wei Chen, Xiao-Ping Yu
This study aimed to investigate the role of focal adhesion kinase (FAK) signaling in the inhibitory effects of black rice anthocyanins (BRACs) on human epidermal growth factor receptor-2 (HER-2)-positive human breast cancer cell metastasis, using the MCF-10A, MCF-7 and MDA-MB-453 cells. BRACs exerted an anti-metastatic effect on the HER-2-positive breast cancer cells. The effects of BRACs on the proliferation of the MDA-MB-453 cells were examined by cell counting kit-8 assay. A wound-healing assay was used to examine the effects of BRACs on the migration of the breast cancer cells...
October 11, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29023137/sexual-vs-nonsexual-currently-most-upsetting-trauma-a-fresh-look-at-attenuation-of-sexual-response-alcohol-intoxication-and-post-traumatic-stress
#10
Elizabeth R Bird, Martin Seehuus, Julia R Heiman, Kelly Cue Davis, Jeanette Norris, William H George
This study examined the dependence of sexual response (vaginal pulse amplitude [VPA] and subjective sexual arousal) on alcohol intoxication (.10% breath alcohol concentration [BrAC] versus no alcohol) and the nature of a woman's currently most upsetting traumatic event (C-MUTE), whether it was sexual (e.g., rape) or nonsexual (e.g., combat). Self-reported sexual outcomes were also compared by C-MUTE type. A total of 117 women completed background measures and either drank alcoholic or nonalcoholic beverages...
October 12, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29017890/faulty-brca1-brca2-genes-how-poor-is-the-prognosis
#11
REVIEW
John O'Quigley
We take a critical look at the meaning behind the number 87% given to 25-year-old Sophie, a BRCA1 and BRCA2 carrier. Sophie has been told she has an 87% chance of getting breast cancer. She is contemplating a preventive double mastectomy after genetic counseling and her physician's advice. Some 92% of British general practitioners are in favor of prophylactic mastectomy as a treatment option for women similar to Sophie. The treatment decision results, to a very large extent, from the size of the number (87%) alone...
October 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28942033/nature-versus-intensity-of-intoxication-co-ingestion-of-alcohol-and-energy-drinks-and-the-effect-on-objective-and-subjective-intoxication
#12
Jessica Forward, Jane Akhurst, Raimondo Bruno, Xiao Leong, Amelia VanderNiet, Holly Bromfield, Jacqueline Erny, Tessa Bellamy, Amy Peacock
BACKGROUND: We report a series of studies examining the effect of alcohol mixed with energy drinks (AmEDs) versus alcohol on objective intoxication (breath alcohol concentration; BrAC), intensity, and nature of intoxication. We also aimed to disentangle the role of energy drink (ED) ingredients in any effects. METHOD: Three within-subject double-blind placebo-controlled studies measured BrAC, subjective intoxication and impairment ('intensity of intoxication'), stimulation and sedation ('nature of intoxication') following administration of ED, Cola, Caffeine+Sugar, and Placebo with alcohol (Study 1, n=18); ED, Caffeine-only, Sugar-only and Placebo with alcohol (Study 2, n=20); and ED and Placebo with alcohol (Study 3, n=27)...
September 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28922746/ectopic-expression-of-winding-1-leads-to-asymmetrical-distribution-of-auxin-and-a-spiral-phenotype-in-rice
#13
Ming-Lung Cheng, Shuen-Fang Lo, An-Shan Hsiao, Ya-Fang Hong, Su-May Yu, Tuan-Hua David Ho
Ectopic expression of the rice WINDING 1 (WIN1) gene leads to a spiral phenotype only in shoots but not in roots. Rice WIN1 belongs to a specific class of proteins in cereal plants containing a Bric-a-Brac/Tramtrack/Broad (BTB) complex, a non-phototropic hypocotyl 3 (NPH3) domain and a coiled-coil motif. The WIN1 protein is predominantly localized to the plasma membrane, but is also co-localized to plasmodesmata, where it exhibits a punctate pattern. It is observed that WIN1 is normally expressed in roots and the shoot-root junction, but not in the rest of shoots...
September 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28827238/making-a-balanced-plate-for-pregnant-women-to-improve-birthweight-of-infants-a-study-protocol-for-a-cluster-randomised-controlled-trial-in-rural-bangladesh
#14
Morseda Chowdhury, Camille Raynes-Greenow, Ashraful Alam, Michael J Dibley
OBJECTIVES: Low birthweight significantly contributes to neonatal mortality, morbidities and psychosocial debilities throughout the course of life. A large proportion of infants (36-55%) in Bangladesh is born with low birthweight. Nutritional status of women during pregnancy is critical for optimal growth and development of the fetus. Nutrition education has been found to improve maternal nutritional status. Our study aims to determine whether nutrition education with a practical demonstration during pregnancy is an effective intervention for improving the birthweight of infants compared with standard nutrition education only...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28807454/reconsidering-olfactory-bulb-magnetic-resonance-patterns-in-kallmann-syndrome
#15
Thomas Hacquart, Aïcha Ltaief-Boudrigua, Cécile Jeannerod, Salem Hannoun, Gérald Raverot, Michel Pugeat, Aude Brac de la Perriere, Véronique Lapras, Frédérique Nugues, Catherine Dode, Francois Cotton
OBJECTIVE: The aim of this retrospective study was to perform magnetic resonance imaging assessment of olfactory pathway and skull base abnormalities in Kallmann syndrome (KS) patients with hypogonadotropic hypogonadism and olfaction disorder. METHODS: Magnetic resonance brain patterns were retrospectively studied in 19 patients clinically classified as KS. Qualitative assessment of olfactory bulb region comprised bulb atrophy and rectus and medial orbital gyrus ptosis; quantitative assessment measured olfactory fossa depth and width, sulcus depth and ethmoid angle...
August 11, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28777684/concussion-history-hazardous-drinking-and-brac-levels-among-a-sample-of-bar-patrons-2015
#16
Ryan J Martin, Beth H Chaney, Joseph G L Lee
BACKGROUND: Alcohol consumption and experiencing a concussion are positively correlated. Concussion history has not been examined previously in any alcohol field study (i.e., conducted in a natural setting). OBJECTIVE: To better understand the relationship between concussion history and alcohol consumption. METHODS: We conducted two anonymous field studies among a 2015 sample of bar patrons (N = 544; 62.5% males) in a college town to assess concussion history and two alcohol consumption measures: (1) breath alcohol concentration (BrAC) levels and (2) hazardous drinking scores (based on the AUDIT-C)...
August 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28753669/multiscale-adaptive-analysis-of-circadian-rhythms-and-intradaily-variability-application-to-actigraphy-time-series-in-acute-insomnia-subjects
#17
Ruben Fossion, Ana Leonor Rivera, Juan C Toledo-Roy, Jason Ellis, Maia Angelova
Circadian rhythms become less dominant and less regular with chronic-degenerative disease, such that to accurately assess these pathological conditions it is important to quantify not only periodic characteristics but also more irregular aspects of the corresponding time series. Novel data-adaptive techniques, such as singular spectrum analysis (SSA), allow for the decomposition of experimental time series, in a model-free way, into a trend, quasiperiodic components and noise fluctuations. We compared SSA with the traditional techniques of cosinor analysis and intradaily variability using 1-week continuous actigraphy data in young adults with acute insomnia and healthy age-matched controls...
2017: PloS One
https://www.readbyqxmd.com/read/28743001/gcl-and-cul3-control-the-switch-between-cell-lineages-by-mediating-localized-degradation-of-an-rtk
#18
Juhee Pae, Ryan M Cinalli, Antonio Marzio, Michele Pagano, Ruth Lehmann
The separation of germline from somatic lineages is fundamental to reproduction and species preservation. Here, we show that Drosophila Germ cell-less (GCL) is a critical component in this process by acting as a switch that turns off a somatic lineage pathway. GCL, a conserved BTB (Broad-complex, Tramtrack, and Bric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3(GCL)). We show that CRL3(GCL) promotes PGC fate by mediating degradation of Torso, a receptor tyrosine kinase (RTK) and major determinant of somatic cell fate...
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28722214/impairment-due-to-combined-sleep-restriction-and-alcohol-is-not-mitigated-by-decaying-breath-alcohol-concentration-or-rest-breaks
#19
Jessica E Manousakis, Clare Anderson
OBJECTIVE: Epidemiological and laboratory-based driving simulator studies have shown the detrimental impact of moderate, legal levels of alcohol consumption on driving performance in sleepy drivers. As less is known about the time course of decaying alcohol alongside performance impairment, our study examined impairment and recovery of performance alongside decaying levels of alcohol, with and without sleep restriction. METHODS: Sixteen healthy young males (18-27 years) underwent 4 counterbalanced conditions: Baseline, Alcohol (breath alcohol concentration [BrAC] < 0...
July 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28683518/factors-associated-with-self-estimated-breath-alcohol-concentration-among-bar-patrons
#20
Matthew E Rossheim, Adam E Barry, Dennis L Thombs, Robert M Weiler, Jenna R Krall, Caroline J Stephenson, Scott T Walters, Mark B Reed, John D Clapp, Sumihiro Suzuki, Tracey E Barnett, M Brad Cannell
BACKGROUND: Few studies have examined the context in which drinkers underestimate their breath alcohol concentration (BrAC) in natural drinking environments. This study examined factors associated with bar patrons' self-estimated BrAC in high-risk college town settings. METHODS: Guided interview and BrAC data were collected from 510 participants recruited as they exited bars located close to large universities: 1 in Florida and 1 in Texas. RESULTS: Participants with the highest measured BrACs underestimated their BrAC levels the most...
July 6, 2017: Alcoholism, Clinical and Experimental Research
keyword
keyword
86386
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"