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https://www.readbyqxmd.com/read/28807454/reconsidering-olfactory-bulb-magnetic-resonance-patterns-in-kallmann-syndrome
#1
Thomas Hacquart, Aïcha Ltaief-Boudrigua, Cécile Jeannerod, Salem Hannoun, Gérald Raverot, Michel Pugeat, Aude Brac de la Perriere, Véronique Lapras, Frédérique Nugues, Catherine Dode, Francois Cotton
OBJECTIVE: The aim of this retrospective study was to perform magnetic resonance imaging assessment of olfactory pathway and skull base abnormalities in Kallmann syndrome (KS) patients with hypogonadotropic hypogonadism and olfaction disorder. METHODS: Magnetic resonance brain patterns were retrospectively studied in 19 patients clinically classified as KS. Qualitative assessment of olfactory bulb region comprised bulb atrophy and rectus and medial orbital gyrus ptosis; quantitative assessment measured olfactory fossa depth and width, sulcus depth and ethmoid angle...
August 11, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28777684/concussion-history-hazardous-drinking-and-brac-levels-among-a-sample-of-bar-patrons-2015
#2
Ryan J Martin, Beth H Chaney, Joseph G L Lee
BACKGROUND: Alcohol consumption and experiencing a concussion are positively correlated. Concussion history has not been examined previously in any alcohol field study (i.e., conducted in a natural setting). OBJECTIVE: To better understand the relationship between concussion history and alcohol consumption. METHODS: We conducted two anonymous field studies among a 2015 sample of bar patrons (N = 544; 62.5% males) in a college town to assess concussion history and two alcohol consumption measures: (1) breath alcohol concentration (BrAC) levels and (2) hazardous drinking scores (based on the AUDIT-C)...
August 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28753669/multiscale-adaptive-analysis-of-circadian-rhythms-and-intradaily-variability-application-to-actigraphy-time-series-in-acute-insomnia-subjects
#3
Ruben Fossion, Ana Leonor Rivera, Juan C Toledo-Roy, Jason Ellis, Maia Angelova
Circadian rhythms become less dominant and less regular with chronic-degenerative disease, such that to accurately assess these pathological conditions it is important to quantify not only periodic characteristics but also more irregular aspects of the corresponding time series. Novel data-adaptive techniques, such as singular spectrum analysis (SSA), allow for the decomposition of experimental time series, in a model-free way, into a trend, quasiperiodic components and noise fluctuations. We compared SSA with the traditional techniques of cosinor analysis and intradaily variability using 1-week continuous actigraphy data in young adults with acute insomnia and healthy age-matched controls...
2017: PloS One
https://www.readbyqxmd.com/read/28743001/gcl-and-cul3-control-the-switch-between-cell-lineages-by-mediating-localized-degradation-of-an-rtk
#4
Juhee Pae, Ryan M Cinalli, Antonio Marzio, Michele Pagano, Ruth Lehmann
The separation of germline from somatic lineages is fundamental to reproduction and species preservation. Here, we show that Drosophila Germ cell-less (GCL) is a critical component in this process by acting as a switch that turns off a somatic lineage pathway. GCL, a conserved BTB (Broad-complex, Tramtrack, and Bric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3(GCL)). We show that CRL3(GCL) promotes PGC fate by mediating degradation of Torso, a receptor tyrosine kinase (RTK) and major determinant of somatic cell fate...
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28722214/impairment-due-to-combined-sleep-restriction-and-alcohol-is-not-mitigated-by-decaying-breath-alcohol-concentration-or-rest-breaks
#5
Jessica E Manousakis, Clare Anderson
OBJECTIVE: Epidemiological and laboratory-based driving simulator studies have shown the detrimental impact of moderate, legal levels of alcohol consumption on driving performance in sleepy drivers. As less is known about the time course of decaying alcohol alongside performance impairment, our study examined impairment and recovery of performance alongside decaying levels of alcohol, with and without sleep restriction. METHODS: Sixteen healthy young males (18-27 years) underwent 4 counterbalanced conditions: Baseline, Alcohol (breath alcohol concentration [BrAC] < 0...
July 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28683518/factors-associated-with-self-estimated-breath-alcohol-concentration-among-bar-patrons
#6
Matthew E Rossheim, Adam E Barry, Dennis L Thombs, Robert M Weiler, Jenna R Krall, Caroline J Stephenson, Scott T Walters, Mark B Reed, John D Clapp, Sumihiro Suzuki, Tracey E Barnett, M Brad Cannell
BACKGROUND: Few studies have examined the context in which drinkers underestimate their breath alcohol concentration (BrAC) in natural drinking environments. This study examined factors associated with bar patrons' self-estimated BrAC in high-risk college town settings. METHODS: Guided interview and BrAC data were collected from 510 participants recruited as they exited bars located close to large universities: 1 in Florida and 1 in Texas. RESULTS: Participants with the highest measured BrACs underestimated their BrAC levels the most...
July 6, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28599472/nucleus-accumbens-1-gadd45gip1-axis-mediates-cisplatin-resistance-through-cellular-senescence-in-ovarian-cancer
#7
Kentaro Nakayama, Munmun Rahman, Mohammed Tanjimur Rahman, Kohei Nakamura, Emi Sato, Hiroshi Katagiri, Tomoka Ishibashi, Masako Ishikawa, Kouji Iida, Sultana Razia, Noriyuki Ishikawa, Satoru Kyo
Nucleus accumbens-1 (NAC1), a nuclear factor belonging to the bric-a-brac-tramtrack-broad complex/pox virus and zinc finger gene family, is known to serve important roles in the proliferation and growth of tumor cells, and in chemotherapy resistance. However, the underlying molecular mechanisms through which NAC1 contributes to drug resistance remain unclear. In the present study, the role of NAC1 in drug resistance in ovarian cancer was investigated. NAC1 expression was markedly negatively associated with growth arrest and DNA-damage-inducible 45γ-interacting protein 1 (GADD45GIP1) expression in ovarian cancer...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28546827/chemical-constituents-from-a-gynostemma-laxum-and-their-antioxidant-and-neuroprotective-activities
#8
Ji Yeon Seo, Sang Kyum Kim, Phi Hung Nguyen, Ju Yong Lee, Pham Ha Thanh Tung, Sang Hyun Sung, Won Keun Oh
BACKGROUND: A few bioactivities of constituents from Gynostemma laxum, which has been collected in Vietnam, have been reported until now. There is no report about the effects of constituents from G. laxum although the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) antioxidant defense system is involved in neuroprotection in the brain. Therefore, we investigated whether quercetin (2), benzoic acid (10) and their analogues (1, 3-9 and 11) from G. laxum have the antioxidant and neuroprotective activities and also their underlying mechanism...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28545427/advantages-and-limitations-for-users-of-double-pit-pour-flush-latrines-a-qualitative-study-in-rural-bangladesh
#9
Faruqe Hussain, Thomas Clasen, Shahinoor Akter, Victoria Bawel, Stephen P Luby, Elli Leontsini, Leanne Unicomb, Milan Kanti Barua, Brittany Thomas, Peter J Winch
BACKGROUND: In rural Bangladesh, India and elsewhere, pour-flush pit latrines are the most common sanitation system. When a single pit latrine becomes full, users must empty it themselves and risk exposure to fresh feces, pay an emptying service to remove pit contents or build a new latrine. Double pit pour-flush latrines may serve as a long-term sanitation option including high water table areas because the pits do not need to be emptied immediately and the excreta decomposes into reusable soil...
May 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28493742/effects-of-alcohol-initial-gambling-outcomes-impulsivity-and-gambling-cognitions-on-gambling-behavior-using-a-video-poker-task
#10
RANDOMIZED CONTROLLED TRIAL
William R Corbin, Jessica M Cronce
Drinking and gambling frequently co-occur, and concurrent gambling and drinking may lead to greater negative consequences than either behavior alone. Building on prior research on the effects of alcohol, initial gambling outcomes, impulsivity, and gambling cognitions on gambling behaviors using a chance-based (nonstrategic) slot-machine task, the current study explored the impact of these factors on a skill-based (strategic) video poker task. We anticipated larger average bets and greater gambling persistence under alcohol relative to placebo, and expected alcohol effects to be moderated by initial gambling outcomes, impulsivity, and gambling cognitions...
June 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28420366/pirfenidone-attenuates-bleomycin-induced-pulmonary-fibrosis-in-mice-by-regulating-nrf2-bach1-equilibrium
#11
Yuan Liu, Fuai Lu, Lirong Kang, Zhihua Wang, Yongfu Wang
BACKGROUND: Oxidative stress is one of the important factors involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The equilibrium of Nuclear factor-erythroid-related factor 2 (Nrf2)/[BTB (broad-complex, tramtrack and bric-a-brac) and CNC (cap'n'collar protein) homology 1, Bach1] determines the expression level of antioxidant factors, further regulating the function of oxidation/antioxidation capacity. Pirfenidone (PFD) is one of two currently for IPF therapy approved drugs...
April 18, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28394894/tissue-specific-enhancer-repression-through-molecular-integration-of-cell-signaling-inputs
#12
Luis Humberto Mojica-Vázquez, Mikhail H Benetah, Aissette Baanannou, Sandra Bernat-Fabre, Bart Deplancke, David L Cribbs, Henri-Marc Bourbon, Muriel Boube
Drosophila leg morphogenesis occurs under the control of a relatively well-known genetic cascade, which mobilizes both cell signaling pathways and tissue-specific transcription factors. However, their cross-regulatory interactions, deployed to refine leg patterning, remain poorly characterized at the gene expression level. Within the genetically interacting landscape that governs limb development, the bric-à-brac2 (bab2) gene is required for distal leg segmentation. We have previously shown that the Distal-less (Dll) homeodomain and Rotund (Rn) zinc-finger activating transcription factors control limb-specific bab2 expression by binding directly a single critical leg/antennal enhancer (LAE) within the bric-à-brac locus...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28356112/predictors-of-breath-alcohol-concentrations-in-college-parties
#13
Julie M Croff, Eleanor Leavens, Kathleen Olson
BACKGROUND: Alcohol use and subsequent consequences are harmful for individual college students. Other students and the university can also be negatively impacted by the consequences of alcohol use. METHOD: A field-based study was used to assess the alcohol use environment at college parties. Researchers replicated a previous study by driving and walking a route to identify parties primarily on Thursday, Friday, and Saturday evenings between 9:00 PM and 1:00 AM across an academic year...
March 30, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28351361/lost-in-care-pathway-a-qualitative-investigation-on-the-health-system-delay-of-extra-pulmonary-tuberculosis-patients-in-bangladesh
#14
Malabika Sarker, Din Mohammad, Sukanta Paul, Rahima Akter, Shayla Islam, Goutam Biswas, Asheque Hossain, Akramul Islam
BACKGROUND: Although extra pulmonary tuberculosis (EPTB) has long been known as a major public health concern globally, the complex healthcare-seeking pathways of EPTB patients are not widely studied. This study aims to explore the pattern of healthcare-seeking pathways of rural and urban EPTB patients registered with the BRAC TB control programme. BRAC is a Bangladesh-based non-governmental organization dedicated to alleviating poverty through empowering the poor. METHOD: Data were collected through 60 in-depth interviews with rural and urban EPTB patients in Bangladesh...
March 28, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28343115/patterns-of-drinking-and-driving-offenses-among-nightclub-patrons-in-brazil
#15
Gabriela A Wagner, Zila M Sanchez
BACKGROUND: Brazil has a strict drinking and driving law known as the Brazilian "Dry Law". The aim of the present study was to investigate characteristics associated with the breaking of the Brazilian traffic law, on drinking and driving, at nightclub exit among a representative sample of nightclub patrons in the city of São Paulo, Brazil. METHODS: Portal survey realized with a two-stage cluster sampling survey design to collect data from 2422 patrons at the entrance and 1822 patrons at the exit of 31 nightclubs in the city of São Paulo, Brazil...
May 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28321939/examining-the-sociocultural-sensitivity-of-subjective-drunkenness-comparing-arab-and-jewish-israeli-pub-patrons
#16
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
INTRODUCTION AND AIMS: Subjective drunkenness measures may be useful screening tools for alcohol-related problems. However, if self-reported drunkenness is influenced by social and cultural understandings, the measure may not predict drinking patterns equally across different sociocultural groups. The current study aims to determine whether the two main sociocultural groups in Israel (Arabs and Jews) are equally likely to report drunkenness at comparable levels of breath alcohol content (BrAC)...
March 20, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28268221/cross-cultural-validity-in-self-reported-alcohol-use
#17
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
BACKGROUND AND AIM: Little evidence is available on whether respondents from divergent sociocultural populations report alcohol consumption in systematically similar ways. Therefore, this study examined whether the validity of self-reported alcohol use differed between Arab and Jewish Israeli pub patrons. METHODS: The analytical sample consisted of 227 Arab and 900 Jewish Israeli pub patrons who were approached as they left pubs and asked to record their Breath Alcohol Content (BrAC) value and complete a questionnaire that probed into their alcohol use...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28262621/development-and-validation-of-a-model-to-predict-blood-alcohol-concentrations-updating-the-nhtsa-equation
#18
Yiqi Zhang, Changxu Wu, Jingyan Wan
OBJECTS: To date, multiple models have been developed to estimate blood or breath alcohol concentration (BAC/BrAC). Several factors have been identified that affect the discrepancy between BACs/BrACs and retrospective estimation (eBAC) with existing equations. To the best of our knowledge, a model to quantify the effects of factors on the discrepancy between BAC/BrAC and eBAC is still nonexistent. The goal of this work was to develop a model to provide a more accurate retrospective estimation of breath alcohol concentration (eBAC)...
February 17, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28256401/gemcitabine-as-second-line-chemotherapy-after-folfirinox-failure-in-advanced-pancreatic-adenocarcinoma-a-retrospective-study
#19
Juliette Viaud, Clémence Brac, Pascal Artru, Estelle Le Pabic, Bérengère Leconte, Anaïs Bodère, Marc Pracht, Samuel Le Sourd, Julien Edeline, Astrid Lièvre
BACKGROUND: Pancreatic adenocarcinoma (PA) is diagnosed in most cases at an advanced stage requiring chemotherapy. Folfirinox is the standard first-line treatment. After Folfirinox failure, gemcitabine alone is routinely used as second-line therapy without data supporting this attitude. AIM: Determine the response rate and outcome of patients with advanced PA treated with gemcitabine after Folfirinox failure. METHODS: We retrospectively analyzed all consecutive patients treated with gemcitabine after Folfirinox failure for a locally advanced or metastatic PA between 2009 and 2015...
June 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28087460/identification-of-the-doublesex-protein-binding-sites-that-activate-expression-of-lozenge-in-the-female-genital-disc-in-drosophila-melanogaster
#20
Shunsuke Wagamitsu, Dan Takase, Fugaku Aoki, Masataka G Suzuki
Normal sexual differentiation in the genital organs is essential for the animal species that use sexual reproduction. Although it is known that doublesex (dsx) is required for the sexual development of the genitalia in various insect species, the direct target genes responsible for the sexual differentiation of the genitalia have not been identified. The lozenge (lz) gene is expressed in the female genital disc and is essential for developments of spermathecae and accessory glands in Drosophila melanogaster...
January 10, 2017: Mechanisms of Development
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