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https://www.readbyqxmd.com/read/29453202/management-of-endocrine-disease-hyperandrogenic-states-in-women-pitfalls-in-laboratory-diagnosis
#1
Michel Pugeat, Ingrid Plotton, Aude Brac de la Perrière, Gerald Raverot, Henri Déchaud, Véronique Raverot
Measuring total testosterone level is the first-line approach in assessing androgen excess in women. The main pitfalls in measuring testosterone relate to its low concentration and to the structural similarity between circulating androgens and testosterone, requiring accurate techniques with high specificity and sensitivity. These goals can be achieved by immunoassay using a specific anti-testosterone monoclonal antibody, ideally after an extraction step. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) will be commonly used for measuring testosterone, providing optimal accuracy with a low limit of detection...
February 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29392372/inhibiting-automatic-negative-social-responses-in-alcohol-intoxication-interactions-with-theory-of-mind-ability-and-level-of-task-guidance
#2
Emma G Johnson, Sarah Skromanis, Raimondo Bruno, Jonathan Mond, Cynthia A Honan
RATIONALE: Alcohol intoxication is associated with socially disinhibited behaviours that may reflect impaired social cognitive abilities that guide social behaviour. The effects of alcohol on social cognition and how this may contribute to disinhibited behaviour are poorly understood. The aim of this study was to examine whether intoxicated individuals could inhibit automatic negative responses to negative social information, whether these difficulties were reliant on theory of mind (ToM) ability and whether intoxicated individuals were able to adjust verbal responses when provided with guidelines about how to respond...
February 1, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29337586/differential-development-of-acute-tolerance-may-explain-heightened-rates-of-impaired-driving-after-consumption-of-alcohol-mixed-with-energy-drinks-versus-alcohol-alone
#3
Cecile A Marczinski, Amy L Stamates, Sarah F Maloney
Consumers of alcohol mixed with energy drinks (AmED) are more likely to drive while impaired when compared to alcohol alone consumers. In addition, acute tolerance to the internal cues of feelings of intoxication is known to contribute to maladaptive decisions to drive while impaired. Therefore, the purpose of this study was to determine whether there is differential development of acute tolerance for AmED versus alcohol alone for ratings of willingness to drive after alcohol consumption. Social drinkers (n = 12) attended 4 separate sessions where they received alcohol and energy drinks, alone and in combination...
January 15, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29329406/judgement-of-breath-alcohol-concentration-levels-among-pedestrians-in-the-night-time-economy-a-street-intercept-field-study
#4
M P Cameron, M J Roskruge, N Droste, P G Miller
Aims: To evaluate how well people in the night-time economy can assess their own breath alcohol concentration (BrAC), in the context of a change in breath alcohol limits for driving. Methods: We conducted a field study of 242 participants over 5 nights in the central business district of a university town in New Zealand. Participants completed a short survey, which included questions on their self-reported level of intoxication and the self-estimated BrAC. At the conclusion of the interview each participant was breath-tested...
January 10, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29323932/the-effects-of-breath-alcohol-concentration-on-postural-control
#5
Dary D Fiorentino
STRUCTURED ABSTRACT Background: Two of the three standardized field sobriety tests that US law enforcement uses at roadside checks have a postural equilibrium component to them. Those tests have been validated to detect impairment caused by blood alcohol concentrations (BACs) of .08 g/dL or above. Many medical and traffic safety associations support a lower limit, and one state, Utah, has passed a law to lower the limit to .05 g/dL. Many studies have examined the effects of alcohol on postural control (of which postural equilibrium is a component), with a consensus emerging that impairment is usually found at BACs greater than ...
January 11, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29297463/cis-regulatory-evolution-integrated-the-bric-%C3%A3-brac-transcription-factors-into-a-novel-fruit-fly-gene-regulatory-network
#6
Maxwell J Roeske, Eric M Camino, Sumant Grover, Mark Rebeiz, Thomas Michael Williams
Gene expression evolution through gene regulatory network (GRN) changes has gained appreciation as a driver of morphological evolution. However, understanding how GRNs evolve is hampered by finding relevant cis-regulatory element (CRE) mutations, and interpreting the protein-DNA interactions they alter. We investigated evolutionary changes in the duplicated Bric-à-brac (Bab) transcription factors and a key Bab target gene in a GRN underlying the novel dimorphic pigmentation of D. melanogaster and its relatives...
January 3, 2018: ELife
https://www.readbyqxmd.com/read/29281165/an-intercept-study-to-measure-the-extent-to-which-new-zealand-university-students-pre-game
#7
Benjamin C Riordan, Tamlin S Conner, Jayde A M Flett, Nic Droste, Louise Cody, Kate L Brookie, Jessica K Riordan, Damian Scarf
OBJECTIVE: We aimed to quantify the degree to which students pre-gamed in New Zealand, using self-report and breathalysers. METHODS: A total of 569 New Zealand undergraduate students were interviewed (men = 45.2%; first year = 81.4%) entering three university-run concerts. We asked participants to report how many drinks they had consumed, their self-reported intoxication and the duration of their pre-gaming session. We then recorded participants' Breath Alcohol Concentration (BrAC; µg/L) and the time they arrived at the event...
December 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29277283/correlation-between-blood-alcohol-concentration-bac-breath-alcohol-concentration-brac-and-psychomotor-evaluation-in-a-clinical-monitored-study-of-alcohol-intake-in-brazil
#8
Ana Paula Drummond-Lage, Rodrigo Gomes de Freitas, Gabriel Cruz, Luigi Perillo, Marco Antonio Paiva, Alberto Julius Alves Wainstein
BACKGROUND: Policies that establish maximum blood alcohol concentrations (BACs) or breath alcohol concentration (BrACs) for drivers while driving can reduce traffic accidents by approximately 20%. In Brazil, the National Transit Council (CONTRAN) considers positive BAC and/or BrAC tests or signs of psychomotor capacity alterations as evaluated by a police authority to be an administrative infraction or even a crime. The observed clinical symptoms of alcohol intoxication based on a subject's appearance may not necessarily reflect the quantified BAC and/or BrAC...
February 2018: Alcohol
https://www.readbyqxmd.com/read/29237697/triple-a-syndrome-a-wide-spectrum-of-adrenal-dysfunction
#9
Florence Roucher-Boulez, Aude Brac de la Perrière, Aude Jacquez, Delphine Chau, Laurence Guignat, Christophe Vial, Yves Morel, Marc Nicolino, Gerald Raverot, Michel Pugeat
Objective: Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the AAAS gene which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: Alacrima, Achalasia and Adrenal Insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients. Methods: A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center...
December 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29233567/obtaining-continuous-brac-bac-estimates-in-the-field-a-hybrid-system-integrating-transdermal-alcohol-biosensor-intellidrink-smartphone-app-and-brac-estimator-software-tools
#10
Susan E Luczak, Ashley L Hawkins, Zheng Dai, Raphael Wichmann, Chunming Wang, I Gary Rosen
Biosensors have been developed to measure transdermal alcohol concentration (TAC), but converting TAC into interpretable indices of blood/breath alcohol concentration (BAC/BrAC) is difficult because of variations that occur in TAC across individuals, drinking episodes, and devices. We have developed mathematical models and the BrAC Estimator software for calibrating and inverting TAC into quantifiable BrAC estimates (eBrAC). The calibration protocol to determine the individualized parameters for a specific individual wearing a specific device requires a drinking session in which BrAC and TAC measurements are obtained simultaneously...
December 2, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29227240/pre-drinking-and-the-temporal-gradient-of-intoxication-in-a-new-zealand-nightlife-environment
#11
Michael P Cameron, Matthew J Roskruge, Nic Droste, Peter G Miller
OBJECTIVE: We measured changes in the average level of intoxication over time in the nighttime economy and identified the factors associated with intoxication, including pre-drinking. METHOD: A random intercept sample of 320 pedestrians (105 women; 215 men) was interviewed and received breath alcohol analysis in the nighttime economy of Hamilton, New Zealand. Data were collected over a five-night period, between 7 P.M. and 2:30 A.M. Data were analyzed by plotting the moving average breath alcohol concentration (BrAC) over time and using linear regression models to identify the factors associated with BrAC...
January 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29214468/effects-of-acute-alcohol-and-driving-complexity-in-older-and-younger-adults
#12
Julianne L Price, Ben Lewis, Jeff Boissoneault, Ian R Frazier, Sara Jo Nixon
RATIONALE: Our previous work demonstrated differential neurobehavioral effects of low-dose alcohol consumption on older and younger adults in a driving simulator. However, the ability to enhance or suppress a response in such context has yet to be examined. OBJECTIVES: The current study contrasted older and younger drivers' responses to specific stimuli (i.e., relevant, irrelevant) in scenarios of differing complexity following low-dose acute alcohol administration...
December 6, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29176950/cardiovascular-and-cutaneous-responses-to-the-combination-of-alcohol-and-soft-drinks-the-way-to-orthostatic-intolerance
#13
Claire Maufrais, Nathalie Charriere, Jean-Pierre Montani
Aim: Acute ingestion of alcohol is often accompanied by cardiovascular dysregulation, malaise and even syncope. The full hemodynamic and cutaneous responses to the combination of alcohol and sugar (i.e., alcopops), a common combination in young people, and the mechanisms for the propensity to orthostatic intolerance are not well established. Thus, the purpose of this study was to evaluate the cardiovascular and cutaneous responses to alcopops in young subjects. Methods: Cardiovascular and cutaneous responses were assessed in 24 healthy young subjects (12 men, 12 women) sitting comfortably and during prolonged active standing with a 30-min baseline and 130 min following ingestion of 400 mL of either: water, water + 48 g sugar, water + vodka (1...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29149458/hormone-therapy-and-patient-satisfaction-with-treatment-in-a-large-cohort-of-diverse-disorders-of-sex-development
#14
Anna Nordenström, Robert Röhle, Ute Thyen, Claire Bouvattier, Jolanta Slowikowska-Hilczer, Nicole Reisch, Hedi Claahsen van der Grinten, Aude Brac de la Perriere, Peggy T Cohen-Kettenis, Birgit Köhler
OBJECTIVES: To describe and investigate the hormone treatments in individuals with different forms of disorders of sex development (DSD) and the patients' own views on their treatment. DESIGN: Multicentre cross-sectional clinical evaluation, dsd-LIFE in 6 European countries from February 2014 to September 2015. PARTICIPANTS: A total of 1040 adolescents and adults (≥16 years) with different DSD conditions. MAIN OUTCOMES MEASURES: Hormone replacement, information received and patient satisfaction...
November 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29143202/tobacco-plants-expressing-the-maize-nitrate-transporter-zmnrt2-1-exhibit-altered-responses-of-growth-and-gene-expression-to-nitrate-and-calcium
#15
Abubakar Ibrahim, Xiao-Lu Jin, Yu-Bin Zhang, Jessica Cruz, Paveena Vichyavichien, Nwadiuto Esiobu, Xing-Hai Zhang
BACKGROUND: Nitrate uptake is a highly regulated process. Understanding the intricate interactions between nitrate availability and genetically-controlled nitrate acquisition and metabolism is essential for improving nitrogen use efficiency and increasing nitrate uptake capacity for plants grown in both nitrate-poor and nitrate-enriched environments. In this report, we introduced into tobacco (Nicotiana tabacum) the constitutively expressed maize high-affinity transporter ZmNrt2.1 gene that would bypass the tight control for the endogenous nitrate-responsive genes...
November 15, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29074243/assessing-the-environmental-quality-of-sediments-from-split-coastal-area-croatia-with-a-battery-of-cell-based-bioassays
#16
Maria Blanco, Elisabet Pérez-Albaladejo, Benjamí Piña, Grozdan Kušpilić, Vesna Milun, Roger Lille-Langøy, Odd André Karlsen, Anders Goksøyr, Cinta Porte
A battery of cell-based bioassays, including PLHC-1 cells, zebrafish-Pxr-transfected COS-7 cells and estrogen receptor-recombinant yeast assay (ER-RYA), were applied to detect the presence of bioactive pollutants in sediments collected from Kaštela Bay and Brač Channel (Croatia). Exposure of PLHC-1 cells to the sediment extracts evidenced significant cytotoxicity and presence of CYP1A inducers in sediments collected in Kaštela Bay, near the industrial zone and cargo port of Split. Sediments from this area, which is highly contaminated with PCBs, HCB, DDTs and γ-HCH, also activated the zebrafish Pxr (zfPxr) reporter system...
October 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29039492/black-rice-derived-anthocyanins-inhibit-her-2-positive-breast-cancer-epithelial-mesenchymal-transition-mediated-metastasis-in%C3%A2-vitro-by-suppressing-fak-signaling
#17
Jie Zhou, Yan-Feng Zhu, Xiang-Yan Chen, Bin Han, Fei Li, Jing-Yao Chen, Xiao-Li Peng, Li-Ping Luo, Wei Chen, Xiao-Ping Yu
This study aimed to investigate the role of focal adhesion kinase (FAK) signaling in the inhibitory effects of black rice anthocyanins (BRACs) on human epidermal growth factor receptor-2 (HER-2)-positive human breast cancer cell metastasis, using the MCF-10A, MCF-7 and MDA-MB-453 cells. BRACs exerted an anti-metastatic effect on the HER-2-positive breast cancer cells. The effects of BRACs on the proliferation of the MDA-MB-453 cells were examined by cell counting kit-8 assay. A wound-healing assay was used to examine the effects of BRACs on the migration of the breast cancer cells...
October 11, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29023137/sexual-vs-nonsexual-currently-most-upsetting-trauma-a-fresh-look-at-attenuation-of-sexual-response-alcohol-intoxication-and-post-traumatic-stress
#18
Elizabeth R Bird, Martin Seehuus, Julia R Heiman, Kelly Cue Davis, Jeanette Norris, William H George
This study examined the dependence of sexual response (vaginal pulse amplitude [VPA] and subjective sexual arousal) on alcohol intoxication (.10% breath alcohol concentration [BrAC] versus no alcohol) and the nature of a woman's currently most upsetting traumatic event (C-MUTE), whether it was sexual (e.g., rape) or nonsexual (e.g., combat). Self-reported sexual outcomes were also compared by C-MUTE type. A total of 117 women completed background measures and either drank alcoholic or nonalcoholic beverages...
October 12, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29017890/faulty-brca1-brca2-genes-how-poor-is-the-prognosis
#19
REVIEW
John O'Quigley
We take a critical look at the meaning behind the number 87% given to 25-year-old Sophie, a BRCA1 and BRCA2 carrier. Sophie has been told she has an 87% chance of getting breast cancer. She is contemplating a preventive double mastectomy after genetic counseling and her physician's advice. Some 92% of British general practitioners are in favor of prophylactic mastectomy as a treatment option for women similar to Sophie. The treatment decision results, to a very large extent, from the size of the number (87%) alone...
October 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28942033/nature-versus-intensity-of-intoxication-co-ingestion-of-alcohol-and-energy-drinks-and-the-effect-on-objective-and-subjective-intoxication
#20
Jessica Forward, Jane Akhurst, Raimondo Bruno, Xiao Leong, Amelia VanderNiet, Holly Bromfield, Jacqueline Erny, Tessa Bellamy, Amy Peacock
BACKGROUND: We report a series of studies examining the effect of alcohol mixed with energy drinks (AmEDs) versus alcohol on objective intoxication (breath alcohol concentration; BrAC), intensity, and nature of intoxication. We also aimed to disentangle the role of energy drink (ED) ingredients in any effects. METHOD: Three within-subject double-blind placebo-controlled studies measured BrAC, subjective intoxication and impairment ('intensity of intoxication'), stimulation and sedation ('nature of intoxication') following administration of ED, Cola, Caffeine+Sugar, and Placebo with alcohol (Study 1, n=18); ED, Caffeine-only, Sugar-only and Placebo with alcohol (Study 2, n=20); and ED and Placebo with alcohol (Study 3, n=27)...
September 7, 2017: Drug and Alcohol Dependence
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