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https://www.readbyqxmd.com/read/28087460/identification-of-the-doublesex-protein-binding-sites-that-activate-expression-of-lozenge-in-the-female-genital-disc-in-drosophila-melanogaster
#1
Shunsuke Wagamitsu, Dan Takase, Fugaku Aoki, Masataka G Suzuki
Normal sexual differentiation in the genital organs is essential for the animal species that use sexual reproduction. Although it is known that doublesex (dsx) is required for the sexual development of the genitalia in various insect species, the direct target genes responsible for the sexual differentiation of the genitalia have not been identified. The lozenge (lz) gene is expressed in the female genital disc and is essential for developments of spermathecae and accessory glands in Drosophila melanogaster...
January 10, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28060381/kctd2-an-adaptor-of-cullin3-e3-ubiquitin-ligase-suppresses-gliomagenesis-by-destabilizing-c-myc
#2
Eun-Jung Kim, Sung-Hak Kim, Xiong Jin, Xun Jin, Hyunggee Kim
Cullin3 E3 ubiquitin ligase ubiquitinates a wide range of substrates through substrate-specific adaptors Bric-a-brac, Tramtrack, and Broad complex (BTB) domain proteins. These E3 ubiquitin ligase complexes are involved in diverse cellular functions. Our recent study demonstrated that decreased Cullin3 expression induces glioma initiation and correlates with poor prognosis of patients with malignant glioma. However, the substrate recognition mechanism associated with tumorigenesis is not completely understood...
January 6, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28050606/long-term-exposure-to-space-s-microgravity-alters-the-time-structure-of-heart-rate-variability-of-astronauts
#3
Kuniaki Otsuka, Germaine Cornelissen, Satoshi Furukawa, Yutaka Kubo, Mitsutoshi Hayashi, Koichi Shibata, Koh Mizuno, Tatsuya Aiba, Hiroshi Ohshima, Chiaki Mukai
BACKGROUND: Spaceflight alters human cardiovascular dynamics. The less negative slope of the fractal scaling of heart rate variability (HRV) of astronauts exposed long-term to microgravity reflects cardiovascular deconditioning. We here focus on specific frequency regions of HRV. METHODS: Ten healthy astronauts (8 men, 49.1 ± 4.2 years) provided five 24-hour electrocardiographic (ECG) records: before launch, 20.8 ± 2.9 (ISS01), 72.5 ± 3.9 (ISS02) and 152.8 ± 16...
December 2016: Heliyon
https://www.readbyqxmd.com/read/28042657/the-influence-of-mixers-containing-artificial-sweetener-or-different-doses-of-carbohydrate-on-breath-alcohol-responses-in-females
#4
Cassie Smith, Peter John Herzig, Andrew Davey, Ben Desbrow, Christopher Irwin
BACKGROUND: Breath alcohol responses may be affected by the presence of carbohydrate (CHO) in a beverage. This study investigated the impact of consuming alcohol with mixers containing various doses of CHO or an artificial sweetener on breath alcohol concentration (BrAC), ratings of intoxication and impairment, and cognitive performance in females. METHODS: Twenty-six females (age 25.1 ± 0.7 years, mean ± standard deviation) completed a crossover study involving 4 trials...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28003245/impulsivity-moderates-subjective-responses-to-alcohol-in-alcohol-dependent-individuals
#5
Jonathan G Westman, Spencer Bujarski, Lara A Ray
AIMS: Studies of social drinkers indicate that subjective response (SR) to alcohol and impulsivity are risk factors for the development of alcohol use disorder which may be related. It is unclear, however, whether there are significant relationships between SR and impulsivity among individuals with alcohol dependence. Using data from an intravenous (IV) alcohol challenge study, the present study is the first to explore the relationship between impulsivity and SR during alcohol administration among alcohol-dependent individuals...
December 20, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27990739/acute-alcohol-effects-on-set-shifting-and-its-moderation-by-baseline-individual-differences-a-latent-variable-analysis
#6
Ozlem Korucuoglu, Kenneth J Sher, Phillip K Wood, John Scott Saults, Lee Altamirano, Akira Miyake, Bruce D Bartholow
AIMS: To compare the acute effects of alcohol on set-shifting task performance (relative to sober baseline performance) during ascending and descending limb breath alcohol concentration (BrAC), as well as possible moderation of these effects by baseline individual differences. DESIGN: Shifting performance was tested during an initial baseline and a subsequent drinking session, during which participants were assigned randomly to one of three beverage conditions (alcohol, placebo or control) and one of two BrAC limb conditions [ascending and descending (A/D) or descending-only (D-only)]...
November 6, 2016: Addiction
https://www.readbyqxmd.com/read/27959875/fecal-indicator-and-ascaris-removal-from-double-pit-latrine-content
#7
Digbijoy Dey, A T M Ridwanul Haque, Babar Kabir, Sharmin Farhat Ubaid
Since May 2006, the BRAC Water, Sanitation and Hygiene (WASH) Programme in Bangladesh has enabled more than 30 million people to achieve hygienic sanitation, contributing to an increase in sanitation coverage from 33 to 83% in programme areas and rapid progress towards universal access. In rural areas, most families have single pit latrines that need to be emptied when full. Since 2007, BRAC has promoted the use of hygienic double-pit latrines. Use of double-pit latrines, where appropriate, is also recommended in the Bangladeshi Draft National Water Supply and Sanitation Strategy...
December 2016: Journal of Water and Health
https://www.readbyqxmd.com/read/27925280/association-between-overall-rate-of-change-in-rising-breath-alcohol-concentration-and-the-magnitude-of-acute-tolerance-of-subjective-intoxication-via-the-mellanby-method
#8
David H Morris, Michael T Amlung, Chia-Lin Tsai, Denis M McCarthy
OBJECTIVE: The magnitude of acute tolerance is a strong predictor of the development of longer-term chronic tolerance and plays a decisive role in risky decisions (e.g., driving after drinking). Therefore, it is important to identify factors that increase the magnitude of this adaptive process. This study explored whether acute tolerance magnitude varied as a function of the overall rate of increase in breath alcohol concentration (BrAC). METHODS: Twenty-nine young adult social drinkers (M age = 22...
December 7, 2016: Human Psychopharmacology
https://www.readbyqxmd.com/read/27918950/association-between-breath-alcohol-concentration-and-waterpipe-lounge-patrons-carbon-monoxide-exposure-a-field-investigation
#9
Eleanor L Leavens, Emma I Brett, Summer Frank, Raees A Shaikh, Thad R Leffingwell, Julie M Croff, Theodore L Wagener
BACKGROUND AND AIMS: Concurrent alcohol use and waterpipe (WP) smoking is common among young adults. WP smokers are more than twice as likely to use alcohol as non-users and frequently consume alcohol immediately before and during a WP smoking session. It is unclear what impact alcohol has on WP smoking patterns and resultant exposure to tobacco-related toxicants. The current research aimed to understand the association between alcohol consumption and WP smoke exposure among WP lounge patrons...
January 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27898696/regulation-of-gonad-morphogenesis-in-drosophila-melanogaster-by-btb-family-transcription-factors
#10
Diane Silva, Kenneth W Olsen, Magdalena N Bednarz, Andrew Droste, Christopher P Lenkeit, Edwin Chaharbakhshi, Emily R Temple-Wood, Jennifer C Jemc
During embryogenesis, primordial germ cells (PGCs) and somatic gonadal precursor cells (SGPs) migrate and coalesce to form the early gonad. A failure of the PGCs and SGPs to form a gonad with the proper architecture not only affects germ cell development, but can also lead to infertility. Therefore, it is critical to identify the molecular mechanisms that function within both the PGCs and SGPs to promote gonad morphogenesis. We have characterized the phenotypes of two genes, longitudinals lacking (lola) and ribbon (rib), that are required for the coalescence and compaction of the embryonic gonad in Drosophila melanogaster...
2016: PloS One
https://www.readbyqxmd.com/read/27836016/reduction-in-malaria-prevalence-and-increase-in-malaria-awareness-in-endemic-districts-of-bangladesh
#11
Mohammad Shafiul Alam, Mohammad Moktadir Kabir, Mohammad Sharif Hossain, Shamsun Naher, Nur E Naznin Ferdous, Wasif Ali Khan, Dinesh Mondal, Jahirul Karim, A K M Shamsuzzaman, Be-Nazir Ahmed, Akramul Islam, Rashidul Haque
BACKGROUND: Malaria is endemic in 13 districts of Bangladesh. A baseline malaria prevalence survey across the endemic districts of Bangladesh was conducted in 2007, when the prevalence was reported around 39.7 per 1000 population. After two rounds of Global Fund to Fight AIDS, Tuberculosis and Malaria (GFATM)-funded intervention by the National Malaria Control Programme (NMCP) and a BRAC-led NGO consortium, a follow-up survey was conducted across the malaria-endemic districts of Bangladesh to measure the change in prevalence rate and in people's knowledge of malaria...
November 11, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27816043/smartphone-based-support-system-soberdiary-coupled-with-a-bluetooth-breathalyser-for-treatment-seeking-alcohol-dependent-patients
#12
Chuang-Wen You, Yen-Chang Chen, Chun-Hsin Chen, Chao-Hui Lee, Po-Hsiu Kuo, Ming-Chyi Huang, Hao-Hua Chu
BACKGROUND: Relapse prevention in patients with alcohol dependence (AD) has long been a clinical challenge. It is vital to provide services with minial restrictions for patients to have access to continuous after-treatment care. The study was aimed to examine the benefits of a smartphone application (SoberDiary) coupled to a Bluetooth breathalyser to assist patients recovering from alcohol dependence (AD). METHODS: This study recruited 38 patients that fulfilled the DSM-IV-TR criteria for AD and who were undergoing an outpatient maintenance program for abstinence...
February 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27798848/control-of-inflorescence-architecture-in-tomato-by-btb-poz-transcriptional-regulators
#13
Cao Xu, Soon Ju Park, Joyce Van Eck, Zachary B Lippman
Plant productivity depends on inflorescences, flower-bearing shoots that originate from the stem cell populations of shoot meristems. Inflorescence architecture determines flower production, which can vary dramatically both between and within species. In tomato plants, formation of multiflowered inflorescences depends on a precisely timed process of meristem maturation mediated by the transcription factor gene TERMINATING FLOWER (TMF), but the underlying mechanism is unknown. We show that TMF protein acts together with homologs of the Arabidopsis BLADE-ON-PETIOLE (BOP) transcriptional cofactors, defined by the conserved BTB (Broad complex, Tramtrack, and Bric-a-brac)/POZ (POX virus and zinc finger) domain...
September 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27775390/using-drinking-data-and-pharmacokinetic-modeling-to-calibrate-transport-model-and-blind-deconvolution-based-data-analysis-software-for-transdermal-alcohol-biosensors
#14
Zheng Dai, I G Rosen, Chuming Wang, Nancy Barnett, Susan E Luczak
Alcohol researchers/clinicians have two ways to collect subject /patient field data, standard-drink self-report and the breath analyzer, neither of which is passive or accurate because active subject participation is required. Transdermal alcohol sensors have been developed to measure transdermal alcohol concentration (TAC), but they are used primarily as abstinence monitors because converting TAC into more meaningful blood/breath alcohol concentration (BAC/BrAC) is difficult. In this paper, BAC/BrAC is estimated from TAC by first calibrating forward distributed parameter-based convolution models for ethanol transport from the blood through the skin using patient-collected drinking data for a single drinking episode and a nonlinear pharmacokinetic metabolic absorption/elimination model to estimate BAC...
October 1, 2016: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/27732596/evaluation-of-maternal-health-service-indicators-in-urban-slum-of-bangladesh
#15
Saira Parveen Jolly, Mahfuzar Rahman, Kaosar Afsana, Fakir Md Yunus, Ahmed M R Chowdhury
BACKGROUND: A continuous influx of poor people to urban slums poses a challenge to Bangladesh's health system as it has failed to tackle maternal morbidity and mortality. BRAC is the largest non-governmental organisation in Bangladesh. BRAC has been working to reduce maternal, neonatal and under-five children morbidity and mortality of slum dwellers in cities. BRAC has been doing this work for a decade through a programme called MANOSHI. This programme provides door-to-door services to its beneficiaries through community health workers (CHWs) and normal delivery service through its delivery and maternity centres...
2016: PloS One
https://www.readbyqxmd.com/read/27698808/increase-of-t-and-b-cells-and-altered-bach2-expression-patterns-in-bone-marrow-trephines-of-imatinib-treated-patients-with-chronic-myelogenous-leukaemia
#16
Maximilian Von Laffert, Mathias Hänel, Manfred Dietel, Ioannis Anagnostopoulos, Korinna Jöhrens
The effect of imatinib on T and B cells in patients with chronic myelogenous leukaemia (CML) is not well understood. An upregulation of the transcription factor Broad-complex-Tramtrack-Bric-a-Brac and Cap'n'collar 1 bZip transcription factor 2 (BACH2), which is involved in the development and differentiation of B cells, was demonstrated in a CML cell line treated with imatinib. The present study retrospectively analysed the expression and distribution of cluster of differentiation (CD)3, CD20 and BACH2 (per 1,000 cells), as well as the co-expression of CD20 and BACH2, using immunohistochemistry in serial bone marrow trephines obtained from 14 CML patients treated with imatinib in comparison to 17 patients with newly diagnosed CML and 6 control trephines...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27650451/laparoscopic-treatment-of-a-large-gastric-pouch-following-gastric-band-slippage
#17
Baptiste Brac, Lionel Rebibo, Jean-Philippe Lemouel, Jean-Marc Regimbeau
INTRODUCTION: Gastric band slippage with formation of a gastric pouch is a frequent complication after gastric banding. There is no consensus on the treatment of this condition, which differs within and between centers. Here, we describe our treatment of a large gastric pouch after gastric band slippage. Despite removal of the band, the pouch caused oral feeding intolerance. METHODS: The video shows our treatment of large gastric pouch following gastric banding and surgical revision...
September 20, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27631614/perceptions-of-breath-alcohol-concentration-brac-levels-among-a-sample-of-bar-patrons-with-brac-values-of-0-08-or-higher
#18
Ryan J Martin, Beth H Chaney, Jennifer Cremeens-Matthews, Karen Vail-Smith
Breath alcohol concentration (BrAC) is a commonly used measure of alcohol intoxication. Because of the potential negative consequences of excessive alcohol consumption, it is important to examine how accurately intoxicated individuals can estimate their BrAC values, especially individuals over the legal BrAC driving threshold (i.e., 0.08%). To better understand perceptions of BrAC values among intoxicated individuals, this field study examined actual BrAC values and BrAC range estimates (0.08% and above, 0...
September 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27602024/the-regulatory-protein-rosr-affects-rhizobium-leguminosarum-bv-trifolii-protein-profiles-cell-surface-properties-and-symbiosis-with-clover
#19
Kamila Rachwał, Aleksandra Boguszewska, Joanna Kopcińska, Magdalena Karaś, Marek Tchórzewski, Monika Janczarek
Rhizobium leguminosarum bv. trifolii is capable of establishing a symbiotic relationship with plants from the genus Trifolium. Previously, a regulatory protein encoded by rosR was identified and characterized in this bacterium. RosR possesses a Cys2-His2-type zinc finger motif and belongs to Ros/MucR family of rhizobial transcriptional regulators. Transcriptome profiling of the rosR mutant revealed a role of this protein in several cellular processes, including the synthesis of cell-surface components and polysaccharides, motility, and bacterial metabolism...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27583478/a-controlled-before-and-after-perspective-on-the-improving-maternal-neonatal-and-child-survival-program-in-rural-bangladesh-an-impact-analysis
#20
Mahfuzar Rahman, Fakir Md Yunus, Rasheduzzaman Shah, Fatema Tuz Jhohura, Sabuj Kanti Mistry, Tasmeen Quayyum, Bachera Aktar, Kaosar Afsana
OBJECTIVES: We evaluated the impact of the Improving Maternal, Neonatal, and Child Survival (IMNCS) project, which is being implemented by BRAC in rural communities in Bangladesh. METHODS: Four districts received program intervention i.e. trained community health workers to deliver essential maternal, neonatal, and child healthcare and nutrition services while two districts were treated as comparison group. A quasi-experimental study design (compared before-and-after) was undertaken...
2016: PloS One
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