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Joseph Lane

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https://www.readbyqxmd.com/read/27916520/water-bridge-mediates-recognition-of-mrna-cap-in-eif4e
#1
Dilraj Lama, Mohan R Pradhan, Christopher J Brown, Rohan S Eapen, Thomas L Joseph, Chee-Keong Kwoh, David P Lane, Chandra S Verma
Ligand binding pockets in proteins contain water molecules, which play important roles in modulating protein-ligand interactions. Available crystallographic data for the 5' mRNA cap-binding pocket of the translation initiation factor protein eIF4E shows several structurally conserved waters, which also persist in molecular dynamics simulations. These waters engage an intricate hydrogen-bond network between the cap and protein. Two crystallographic waters in the cleft of the pocket show a high degree of conservation and bridge two residues, which are part of an evolutionarily conserved scaffold...
November 24, 2016: Structure
https://www.readbyqxmd.com/read/27871088/structure-of-photosystem-ii-and-substrate-binding-at-room-temperature
#2
Iris D Young, Mohamed Ibrahim, Ruchira Chatterjee, Sheraz Gul, Franklin D Fuller, Sergey Koroidov, Aaron S Brewster, Rosalie Tran, Roberto Alonso-Mori, Thomas Kroll, Tara Michels-Clark, Hartawan Laksmono, Raymond G Sierra, Claudiu A Stan, Rana Hussein, Miao Zhang, Lacey Douthit, Markus Kubin, Casper de Lichtenberg, Long Vo Pham, Håkan Nilsson, Mun Hon Cheah, Dmitriy Shevela, Claudio Saracini, Mackenzie A Bean, Ina Seuffert, Dimosthenis Sokaras, Tsu-Chien Weng, Ernest Pastor, Clemens Weninger, Thomas Fransson, Louise Lassalle, Philipp Bräuer, Pierre Aller, Peter T Docker, Babak Andi, Allen M Orville, James M Glownia, Silke Nelson, Marcin Sikorski, Diling Zhu, Mark S Hunter, Thomas J Lane, Andy Aquila, Jason E Koglin, Joseph Robinson, Mengning Liang, Sébastien Boutet, Artem Y Lyubimov, Monarin Uervirojnangkoorn, Nigel W Moriarty, Dorothee Liebschner, Pavel V Afonine, David G Waterman, Gwyndaf Evans, Philippe Wernet, Holger Dobbek, William I Weis, Axel T Brunger, Petrus H Zwart, Paul D Adams, Athina Zouni, Johannes Messinger, Uwe Bergmann, Nicholas K Sauter, Jan Kern, Vittal K Yachandra, Junko Yano
Light-induced oxidation of water by photosystem II (PS II) in plants, algae and cyanobacteria has generated most of the dioxygen in the atmosphere. PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). Under illumination, the OEC cycles through five intermediate S-states (S0 to S4), in which S1 is the dark-stable state and S3 is the last semi-stable state before O-O bond formation and O2 evolution...
November 21, 2016: Nature
https://www.readbyqxmd.com/read/27741156/the-role-of-oligosaccharides-in-host-microbial-interactions-for-human-health
#3
Sarah A Ross, Jonathan A Lane, Mariarosaria Marotta, Devon Kavanaugh, Joseph Thomas Ryan, Lokesh Joshi, Rita M Hickey
Milk oligosaccharides have many associated bioactivities which can contribute to human health and offer protective properties to the host. Such bioactivities include anti-infective properties whereby oligosaccharides interact with bacterial cells and prevent adhesion to the host and subsequent colonization. Milk oligosaccharides have also been shown to alter the glycosylation of intestinal cells, leading to a reduction in pathogenic colonization. In addition, these sugars promote adhesion of commensal bacterial strains to host cells as well as possessing the ability to alter mucin expression in intestinal cells and improve barrier function...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27723127/enhanced-electrical-resistivity-and-properties-via-ion-bombardment-of-ferroelectric-thin-films
#4
Sahar Saremi, Ruijuan Xu, Liv R Dedon, Julia A Mundy, Shang-Lin Hsu, Zuhuang Chen, Anoop R Damodaran, Scott P Chapman, Joseph T Evans, Lane W Martin
A novel approach to on-demand improvement of electronic properties in complex-oxide ferroelectrics is demonstrated whereby ion bombardment - commonly used in classic semiconductor materials - is applied to the PbTiO3 system. The result is deterministic reduction in leakage currents by 5 orders of magnitude, improved ferroelectric switching, and unprecedented insights into the nature of defects and intergap state evolution in these materials.
October 10, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27711844/femtosecond-photodissociation-dynamics-of-1-4-diiodobenzene-by-gas-phase-x-ray-scattering-and-photoelectron-spectroscopy
#5
Brian Stankus, James M Budarz, Adam Kirrander, David Rogers, Joseph Robinson, Thomas J Lane, Daniel Ratner, Jerome Hastings, Michael P Minitti, Peter M Weber
We present a multifaceted investigation into the initial photodissociation dynamics of 1,4-diiodobenzene (DIB) following absorption of 267 nm radiation. We combine ultrafast time-resolved photoelectron spectroscopy and X-ray scattering experiments performed at the Linac Coherent Light Source (LCLS) to study the initial electronic excitation and subsequent rotational alignment, and interpret the experiments in light of Complete Active Space Self-Consistent Field (CASSCF) calculations of the excited electronic landscape...
September 19, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27703421/treatment-of-pre-collapse-stages-of-osteonecrosis-of-the-femoral-head-a-systematic-review-of-randomized-control-trials
#6
REVIEW
Jordan C Villa, Solomon Husain, Jelle P van der List, Arianna Gianakos, Joseph M Lane
BACKGROUND: Treatment for osteonecrosis of the femoral head (ONFH) remains controversial. Current reviews include low-level evidence studies evaluating the treatment of both pre-collapse and collapse stages of the disease. QUESTIONS/PURPOSES: The purpose of the current study is to systematically review the literature evaluating core decompression (CD) with bone marrow mesenchymal cells (BMMCs), CD alone, and bisphosphonate treatment in pre-collapse ONFH by focusing just on randomized clinical trials (RCTs) reporting functional and radiologic outcomes...
October 2016: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/27701076/laboratory-evolution-of-artificially-expanded-dna-gives-redesignable-aptamers-that-target-the-toxic-form-of-anthrax-protective-antigen
#7
Elisa Biondi, Joshua D Lane, Debasis Das, Saurja Dasgupta, Joseph A Piccirilli, Shuichi Hoshika, Kevin M Bradley, Bryan A Krantz, Steven A Benner
Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment delivers the first example of an AEGIS aptamer that binds to an isolated protein target, the first whose structural contact with its target has been outlined and the first to inhibit biologically important activities of its target, the protective antigen from Bacillus anthracis We show how rational design based on secondary structure predictions can also direct the use of AEGIS to improve the stability and binding of the aptamer to its target...
November 16, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27696341/veterans-affairs-geriatric-scholars-program-enhancing-existing-primary-care-clinician-skills-in-caring-for-older-veterans
#8
B Josea Kramer, Beth Creekmur, Judith L Howe, Scott Trudeau, Joseph R Douglas, Kimberly Garner, Connie Bales, Carol Callaway-Lane, Steven Barczi
The Veterans Affairs Geriatric Scholars Program (GSP) is a continuing professional development program to integrate geriatrics into the clinical practices of primary care providers and select associated health professions that support primary care teams. GSP uses a blended program educational format, and the minimal requirements are to attend an intensive course in geriatrics, participate in an interactive workshop on quality improvement (QI), and initiate a local QI project to demonstrate application of new knowledge to benefit older veterans...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27552052/synergistic-plasticity-of-intrinsic-conductance-and-electrical-coupling-restores-synchrony-in-an-intact-motor-network
#9
Brian J Lane, Pranit Samarth, Joseph L Ransdell, Satish S Nair, David J Schulz
Motor neurons of the crustacean cardiac ganglion generate virtually identical, synchronized output despite the fact that each neuron uses distinct conductance magnitudes. As a result of this variability, manipulations that target ionic conductances have distinct effects on neurons within the same ganglion, disrupting synchronized motor neuron output that is necessary for proper cardiac function. We hypothesized that robustness in network output is accomplished via plasticity that counters such destabilizing influences...
August 23, 2016: ELife
https://www.readbyqxmd.com/read/27532490/benzene-probes-in-molecular-dynamics-simulations-reveal-novel-binding-sites-for-ligand-design
#10
Yaw Sing Tan, Judith Reeks, Christopher J Brown, Dawn Thean, Fernando Jose Ferrer Gago, Tsz Ying Yuen, Eunice Tze Leng Goh, Xue Er Cheryl Lee, Claire E Jennings, Thomas L Joseph, Rajamani Lakshminarayanan, David P Lane, Martin E M Noble, Chandra S Verma
Protein flexibility poses a major challenge in binding site identification. Several computational pocket detection methods that utilize small-molecule probes in molecular dynamics (MD) simulations have been developed to address this issue. Although they have proven hugely successful at reproducing experimental structural data, their ability to predict new binding sites that are yet to be identified and characterized has not been demonstrated. Here, we report the use of benzenes as probe molecules in ligand-mapping MD (LMMD) simulations to predict the existence of two novel binding sites on the surface of the oncoprotein MDM2...
September 1, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27526873/intracellular-tenofovir-and-emtricitabine-anabolites-in-genital-rectal-and-blood-compartments-from-first-dose-to-steady-state
#11
Sharon M Seifert, Xinhui Chen, Amie L Meditz, Jose R Castillo-Mancilla, Edward M Gardner, Julie A Predhomme, Carolyn Clayton, Gregory Austin, Brent E Palmer, Jia-Hua Zheng, Brandon Klein, Becky J Kerr, L Anthony Guida, Caitlin Rower, Joseph E Rower, Jennifer J Kiser, Lane R Bushman, Samantha MaWhinney, Peter L Anderson
The pharmacokinetics (PK) of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP), the active anabolites of tenofovir disoproxil fumarate (TDF), and emtricitabine (FTC) in blood, genital, and rectal compartments was determined in HIV-positive and seronegative adults who undertook a 60-day intensive PK study of daily TDF/FTC (plus efavirenz in HIV positives). Lymphocyte cell sorting, genital, and rectal sampling occurred once per subject, at staggered visits. Among 19 HIV-positive (3 female) and 21 seronegative (10 female) adults, TFV-DP in peripheral blood mononuclear cells (PBMC) accumulated 8...
October 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27447952/intramolecular-hydrogen-bonding-in-substituted-aminoalcohols
#12
Joseph R Lane, Sidsel D Schrøder, Graham C Saunders, Henrik G Kjaergaard
The qualifying features of a hydrogen bond can be contentious, particularly where the hydrogen bond is due to a constrained intramolecular interaction. Indeed there is disagreement within the literature whether it is even possible for an intramolecular hydrogen bond to form between functional groups on adjacent carbon atoms. This work considers the nature of the intramolecular interaction between the OH (donor) and NH2 (acceptor) groups of 2-aminoethanol, with varying substitution at the OH carbon. Gas-phase vibrational spectra of 1-amino-2-methyl-2-propanol (BMAE) and 1-amino-2,2-bis(trifluoromethyl)-2-ethanol (BFMAE) were recorded using Fourier transform infrared spectroscopy and compared to literature spectra of 2-aminoethanol (AE)...
August 18, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27432972/defective-hiv-1-proviruses-produce-novel-protein-coding-rna-species-in-hiv-infected-patients-on-combination-antiretroviral-therapy
#13
Hiromi Imamichi, Robin L Dewar, Joseph W Adelsberger, Catherine A Rehm, Una O'Doherty, Ellen E Paxinos, Anthony S Fauci, H Clifford Lane
Despite years of plasma HIV-RNA levels <40 copies per milliliter during combination antiretroviral therapy (cART), the majority of HIV-infected patients exhibit persistent seropositivity to HIV-1 and evidence of immune activation. These patients also show persistence of proviruses of HIV-1 in circulating peripheral blood mononuclear cells. Many of these proviruses have been characterized as defective and thus thought to contribute little to HIV-1 pathogenesis. By combining 5'LTR-to-3'LTR single-genome amplification and direct amplicon sequencing, we have identified the presence of "defective" proviruses capable of transcribing novel unspliced HIV-RNA (usHIV-RNA) species in patients at all stages of HIV-1 infection...
August 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27385942/the-efficacy-of-bisphosphonates-with-core-decompression-and-mesenchymal-stem-cells-compared-with-bisphosphonates-alone-in-the-treatment-of-osteonecrosis-of-the-hip-a-retrospective-study
#14
Arianna L Gianakos, Joaquin Moya-Angeler, Shivi Duggal, Lester Zambrana, Kara G Fields, Douglas N Mintz, Charles N Cornell, Joseph M Lane
INTRODUCTION: Osteonecrosis of the femoral head (ONFH) is a devastating disease with complete collapse of the femoral head often reported in greater than 70% of patients within 3 to 4 years of diagnosis. Early intervention prior to collapse may improve the chance of success of joint preserving procedures. QUESTIONS/PURPOSES: The purpose of this study was to evaluate whether core decompression with mesenchymal stem cells combined with bisphosphonate therapy can improve the clinical outcomes and reduce the risk of hip replacement when compared to treatment with bisphosphonate therapy alone...
July 2016: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/27379708/a-phase-2-study-of-the-hsp90-inhibitor-auy922-as-treatment-for-patients-with-refractory-gastrointestinal-stromal-tumors
#15
Johanna C Bendell, Todd M Bauer, Ruth Lamar, Mathew Joseph, William Penley, Dana S Thompson, David R Spigel, Rami Owera, Cassie M Lane, Chris Earwood, Howard A Burris
BACKGROUND: AUY922 is an inhibitor of heat shock protein 90 (Hsp90). Hsp90 inhibitors induce kit degradation in preclinical gastrointestinal stromal tumor (GIST) models. This trial was designed to determine the progression-free survival (PFS) of patients with GIST refractory to or intolerant of imatinib and sunitinib. METHODS: Eligible patients received AUY922 70 mg/mg(2) by intravenous (IV) infusion on days 1, 8, and 15 of 21-day cycles. Treatment continued until progression or unacceptable toxicity...
July 2, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27353212/enhancing-the-effectiveness-of-biological-control-programs-of-invasive-species-through-a-more-comprehensive-pest-management-approach
#16
Joseph M DiTomaso, Robert A Van Steenwyk, Robert M Nowierski, Jennifer L Vollmer, Eric Lane, Earl Chilton, Patrick L Burch, Phil E Cowan, Kenneth Zimmerman, Christopher P Dionigi
Invasive species are one of the greatest economic and ecological threats to agriculture and natural areas in the US and the world. Among the available management tools, biological control provides one of the most economical and long-term effective strategies for managing widespread and damaging invasive species populations of nearly all taxa. However, integrating biological control programs in a more complete integrated pest management approach that utilizes increased information and communication, post-release monitoring, adaptive management practices, long-term stewardship strategies, and new and innovative ecological and genetic technologies can greatly improve the effectiveness of biological control...
January 2017: Pest Management Science
https://www.readbyqxmd.com/read/27239197/coffee-consumption-and-the-incidence-of-colorectal-cancer-in-women
#17
Erik J Groessl, Matthew A Allison, Joseph C Larson, Samuel B Ho, Linda G Snetslaar, Dorothy S Lane, Katie M Tharp, Marcia L Stefanick
Background. Higher coffee consumption has been associated with decreased incidence of colorectal cancer. Our objective was to examine the relationship of coffee intake to colorectal cancer incidence in a large observational cohort of postmenopausal US women. Methods. Data were collected for the Women's Health Initiative Observational Study providing a follow-up period of 12.9 years. The mean age of our sample (N = 83,778 women) was 63.5 years. Daily coffee intake was grouped into 3 categories: None, moderate (>0-<4 cups), and high (4+ cups)...
2016: Journal of Cancer Epidemiology
https://www.readbyqxmd.com/read/27194496/racial-and-socioeconomic-disparities-in-hip-fracture-care
#18
Christopher J Dy, Joseph M Lane, Ting Jung Pan, Michael L Parks, Stephen Lyman
BACKGROUND: Despite declines in both the incidence of and mortality following hip fracture, there are racial and socioeconomic disparities in treatment access and outcomes. We evaluated the presence and implications of disparities in delivery of care, hypothesizing that race and community socioeconomic characteristics would influence quality of care for patients with a hip fracture. METHODS: We collected data from the New York State Department of Health Statewide Planning and Research Cooperative System (SPARCS), which prospectively captures information on all discharges from nonfederal acute-care hospitals in New York State...
May 18, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27189150/using-hounsfield-units-to-assess-osteoporotic-status-on-wrist-computed-tomography-scans-comparison-with-dual-energy-x-ray-absorptiometry
#19
Christine C Johnson, Elizabeth B Gausden, Andrew J Weiland, Joseph M Lane, Joseph J Schreiber
PURPOSE: Rates of evaluation and treatment for osteoporosis following distal radius fragility fractures remain low. As a subset of patients with these fractures undergo diagnostic computed tomography (CT) scan of the wrist, utilizing bone mineral density (BMD) measurements available with this imaging can be used to detect osteopenia or osteoporosis. This information may consequently prompt intervention to prevent a subsequent fracture. The purpose of this study was to determine if Hounsfield unit (HU) measurements at the wrist correlate with BMD measurements of the hip, femoral neck, and lumbar spine and to assess the ability of these HU measurements to detect osteoporosis of the hip...
July 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27154530/the-frank-stinchfield-award-total-hip-arthroplasty-for-femoral-neck-fracture-is-not-a-typical-drg-470-a-propensity-matched-cohort-study
#20
William W Schairer, Joseph M Lane, David A Halsey, Richard Iorio, Douglas E Padgett, Alexander S McLawhorn
BACKGROUND: Hip fractures are a major public health concern. For displaced femoral neck fractures, the needs for medical services during hospitalization and extending beyond hospital discharge after total hip arthroplasty (THA) may be different than the needs after THA performed for osteoarthritis (OA), yet these differences are largely uncharacterized, and the Medicare Severity Diagnosis-Related Groups system does not distinguish between THA performed for fracture and OA. QUESTIONS/PURPOSES: (1) What are the differences in in-hospital and 30-day postoperative clinical outcomes for THA performed for femoral neck fracture versus OA? (2) Is a patient's fracture status, that is whether or not a patient has a femoral neck fracture, associated with differences in in-hospital and 30-day postoperative clinical outcomes after THA? METHODS: The National Surgical Quality Improvement Program (NSQIP) database, which contains outcomes for surgical patients up to 30 days after discharge, was used to identify patients undergoing THA for OA and femoral neck fracture...
May 6, 2016: Clinical Orthopaedics and related Research
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