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JOURNAL ARTICLE
Maximilian T Löffler, Chotigar Ngarmsrikam, Paula Giesler, Gabby B Joseph, Zehra Akkaya, John A Lynch, Nancy E Lane, Michael Nevitt, Charles E McCulloch, Thomas M Link
BACKGROUND: Obesity influences the development of osteoarthritis via low-grade inflammation. Progression of local inflammation (= synovitis) increased with weight gain in overweight and obese women compared to stable weight. Synovitis could be associated with subcutaneous fat (SCF) around the knee. Purpose of the study was to investigate the effect of weight loss on synovitis progression and to assess whether SCF around the knee mediates the relationship between weight loss and synovitis progression...
April 17, 2024: BMC Musculoskeletal Disorders
#2
JOURNAL ARTICLE
Jean-Luc K Kabangu, Takara Newsome-Cuby, Amanda Hernandez, Benson Joseph, John Dugan, Danny Fowler, Momodou G Bah, Lane Fry, Sonia V Eden
Stroke is a major health concern in the USA, disproportionately affecting socioeconomically disadvantaged groups. This study investigates the link between persistent poverty and stroke mortality rates in residents aged 65 and above, positing that sustained economic challenges at the county level correlate with an increase in stroke-related deaths. Persistent poverty refers to a long-term state where a significant portion of a population lives below the poverty threshold for an extended period, typically measured over several decades...
March 25, 2024: Journal of Racial and Ethnic Health Disparities
#3
JOURNAL ARTICLE
Mengfei Chen, Andrew Pekosz, Jason S Villano, Wenjuan Shen, Ruifeng Zhou, Heather Kulaga, Zhexuan Li, Amy Smith, Asiana Gurung, Sarah E Beck, Kenneth W Witwer, Joseph L Mankowski, Murugappan Ramanathan, Nicholas R Rowan, Andrew P Lane
SARS-CoV-2 infection of the upper airway and the subsequent immune response are early, critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro and in a hamster model in vivo, we demonstrated a transition in nasal tropism from olfactory to respiratory epithelium as the virus evolved. Analyzing each variant revealed that SARS-CoV-2 WA1 or Delta infect a proportion of olfactory neurons in addition to the primary target sustentacular cells. The Delta variant possessed broader cellular invasion capacity into the submucosa, while Omicron displayed enhanced nasal respiratory infection and longer retention in the sinonasal epithelium...
March 14, 2024: Journal of Clinical Investigation
#4
JOURNAL ARTICLE
Leeat Granek, Logan Muzyka, Natalie Limoges, Lorraine Kelley-Quon, Jessica Lane, Joseph Ha, Deborah L Benzil, Susan Durham
BACKGROUND AND OBJECTIVES: Evidence suggests that female neurosurgeons experience unique challenges in the workplace including lack of academic advancement, challenges with work-life balance, harassment, and discrimination. How these factors influence the gender gap in neurosurgery remains unclear. This analysis investigated gender differences in pediatric neurosurgeons in professional and nonprofessional activities and responsibilities. METHODS: A survey examining professional activities, work-life balance, family dynamics, career satisfaction, and workplace discrimination and harassment was administered to 495 pediatric neurosurgeons...
March 14, 2024: Neurosurgery
#5
JOURNAL ARTICLE
Jessica A Palakshappa, Jane A E Batt, Sue C Bodine, Bronwen A Connolly, Jason Doles, Jason R Falvey, Lauren E Ferrante, D Clark Files, Michael O Harhay, Kirsten Harrell, Joseph A Hippensteel, Theodore J Iwashyna, James C Jackson, Meghan B Lane-Fall, Michelle Monje, Marc Moss, Dale M Needham, Matthew W Semler, Shouri Lahiri, Lars Larsson, Carla M Sevin, Tarek Sharshar, Benjamin Singer, Troy Stevens, Stephanie P Taylor, Christian R Gomez, Guofei Zhou, Timothy D Girard, Catherine L Hough
Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life of those who survive the acute illness. The mechanisms underlying these impairments are not yet well understood, and evidence-based interventions to minimize the burden on patients remain unproven. The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health assembled a workshop in April 2023 to review the state of the science regarding ARDS-associated brain and muscle dysfunction, to identify gaps in current knowledge, and to determine priorities for future investigation...
March 13, 2024: American Journal of Respiratory and Critical Care Medicine
#6
JOURNAL ARTICLE
Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix, Matthew R Broome, Kate Buccilli, Kristin S Cadenhead, Monica E Calkins, Tyrone D Cannon, Guillermo Cecci, Eric Yu Hai Chen, Kang Ik K Cho, Jimmy Choi, Scott R Clark, Michael J Coleman, Philippe Conus, Cheryl M Corcoran, Barbara A Cornblatt, Covadonga M Diaz-Caneja, Dominic Dwyer, Bjørn H Ebdrup, Lauren M Ellman, Paolo Fusar-Poli, Liliana Galindo, Pablo A Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Robert Glynn, Michael P Harms, Leslie E Horton, René S Kahn, Joseph Kambeitz, Lana Kambeitz-Ilankovic, John M Kane, Tina Kapur, Matcheri S Keshavan, Sung-Wan Kim, Nikolaos Koutsouleris, Marek Kubicki, Jun Soo Kwon, Kerstin Langbein, Kathryn E Lewandowski, Gregory A Light, Daniel Mamah, Patricia J Marcy, Daniel H Mathalon, Patrick D McGorry, Vijay A Mittal, Merete Nordentoft, Angela Nunez, Ofer Pasternak, Godfrey D Pearlson, Jesus Perez, Diana O Perkins, Albert R Powers, David R Roalf, Fred W Sabb, Jason Schiffman, Jai L Shah, Stefan Smesny, Jessica Spark, William S Stone, Gregory P Strauss, Zailyn Tamayo, John Torous, Rachel Upthegrove, Mark Vangel, Swapna Verma, Jijun Wang, Inge Winter-van Rossum, Daniel H Wolf, Phillip Wolff, Stephen J Wood, Alison R Yung, Carla Agurto, Mario Alvarez-Jimenez, Paul Amminger, Marco Armando, Ameneh Asgari-Targhi, John Cahill, Ricardo E Carrión, Eduardo Castro, Suheyla Cetin-Karayumak, M Mallar Chakravarty, Youngsun T Cho, David Cotter, Simon D'Alfonso, Michaela Ennis, Shreyas Fadnavis, Clara Fonteneau, Caroline Gao, Tina Gupta, Raquel E Gur, Ruben C Gur, Holly K Hamilton, Gil D Hoftman, Grace R Jacobs, Johanna Jarcho, Jie Lisa Ji, Christian G Kohler, Paris Alexandros Lalousis, Suzie Lavoie, Martin Lepage, Einat Liebenthal, Josh Mervis, Vishnu Murty, Spero C Nicholas, Lipeng Ning, Nora Penzel, Russell Poldrack, Pablo Polosecki, Danielle N Pratt, Rachel Rabin, Habiballah Rahimi Eichi, Yogesh Rathi, Avraham Reichenberg, Jenna Reinen, Jack Rogers, Bernalyn Ruiz-Yu, Isabelle Scott, Johanna Seitz-Holland, Vinod H Srihari, Agrima Srivastava, Andrew Thompson, Bruce I Turetsky, Barbara C Walsh, Thomas Whitford, Johanna T W Wigman, Beier Yao, Hok Pan Yuen, Uzair Ahmed, Andrew Jin Soo Byun, Yoonho Chung, Kim Do, Larry Hendricks, Kevin Huynh, Clark Jeffries, Erlend Lane, Carsten Langholm, Eric Lin, Valentina Mantua, Gennarina Santorelli, Kosha Ruparel, Eirini Zoupou, Tatiana Adasme, Lauren Addamo, Laura Adery, Munaza Ali, Andrea Auther, Samantha Aversa, Seon-Hwa Baek, Kelly Bates, Alyssa Bathery, Johanna M M Bayer, Rebecca Beedham, Zarina Bilgrami, Sonia Birch, Ilaria Bonoldi, Owen Borders, Renato Borgatti, Lisa Brown, Alejandro Bruna, Holly Carrington, Rolando I Castillo-Passi, Justine Chen, Nicholas Cheng, Ann Ee Ching, Chloe Clifford, Beau-Luke Colton, Pamela Contreras, Sebastián Corral, Stefano Damiani, Monica Done, Andrés Estradé, Brandon Asika Etuka, Melanie Formica, Rachel Furlan, Mia Geljic, Carmela Germano, Ruth Getachew, Mathias Goncalves, Anastasia Haidar, Jessica Hartmann, Anna Jo, Omar John, Sarah Kerins, Melissa Kerr, Irena Kesselring, Honey Kim, Nicholas Kim, Kyle Kinney, Marija Krcmar, Elana Kotler, Melanie Lafanechere, Clarice Lee, Joshua Llerena, Christopher Markiewicz, Priya Matnejl, Alejandro Maturana, Aissata Mavambu, Rocío Mayol-Troncoso, Amelia McDonnell, Alessia McGowan, Danielle McLaughlin, Rebecca McIlhenny, Brittany McQueen, Yohannes Mebrahtu, Martina Mensi, Christy Lai Ming Hui, Yi Nam Suen, Stephanie Ming Yin Wong, Neal Morrell, Mariam Omar, Alice Partridge, Christina Phassouliotis, Anna Pichiecchio, Pierluigi Politi, Christian Porter, Umberto Provenzani, Nicholas Prunier, Jasmine Raj, Susan Ray, Victoria Rayner, Manuel Reyes, Kate Reynolds, Sage Rush, Cesar Salinas, Jashmina Shetty, Callum Snowball, Sophie Tod, Gabriel Turra-Fariña, Daniela Valle, Simone Veale, Sarah Whitson, Alana Wickham, Sarah Youn, Francisco Zamorano, Elissa Zavaglia, Jamie Zinberg, Scott W Woods, Martha E Shenton
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community...
March 7, 2024: Schizophrenia Bulletin
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JOURNAL ARTICLE
Justin L Makovicka, Joseph C Brinkman, Nathan Benner, Aiden J Tokish, M Lane Moore, John M Tokish
Biceps tenodesis has been proven to be an effective treatment for biceps tendon and superior labral pathology. Many techniques including both open and arthroscopic approaches have been reported. Open techniques afford management of the entire proximal biceps tendon but are limited by wound healing issues, increased bleeding, and increased surgical time. Arthroscopic tenodesis offers benefits in terms of surgical efficiency, cosmesis, and bleeding risk. However, standard arthroscopic tenodesis only addresses intra-articular biceps pathology...
February 2024: Arthroscopy Techniques
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JOURNAL ARTICLE
Lauren K Olinger, Beverly McClenaghan, Mehrdad Hajibabaei, Nicole Fahner, Lesley Berghuis, Hoda Rajabi, Patrick Erwin, Chad S Lane, Joseph R Pawlik
Coral reefs are biodiverse ecosystems that rely on trophodynamic transfers from primary producers to consumers through the detrital pathway. The sponge loop hypothesis proposes that sponges consume dissolved organic carbon (DOC) and produce large quantities of detritus on coral reefs, with this turn-over approaching the daily gross primary production of the reef ecosystem. In this study, we collected samples of detritus in the epilithic algal matrix (EAM) and samples from potential sources of detritus over two seasons from the forereef at Carrie Bow Cay, Belize...
2024: PeerJ
#9
JOURNAL ARTICLE
Young-Taek Park, Dongwoon Han, Kyoung-Hoon Kim, Hoguen Kim, Hojung Joseph Yoon, Chris Lane, Byeo-Ri Kim, Joo-Yeon Jeong
OBJECTIVES: This study aimed to evaluate the incidence of health insurance claims recording the cancer stage and TNM codes representing tumor extension size (T), lymph node metastasis (N), and distant metastasis (M) for patients diagnosed with cancer and to determine whether this extracted data could be applied to the new ICD-11 codes. DESIGN: A cross-sectional study design was used, with the units of analysis as individual outpatients. Two dependent variables were extraction feasibility of cancer stage and TNM metastasis information from each claim...
February 24, 2024: BMJ Open
#10
RANDOMIZED CONTROLLED TRIAL
Tim A D Smith, Catharine M L West, Nuradh Joseph, Brian Lane, Joely Irlam-Jones, Elisabet More, Hitesh Mistry, Kimberley J Reeves, Yee Pei Song, Mark Reardon, Peter J Hoskin, Syed A Hussain, Helen Denley, Emma Hall, Nuria Porta, Robert A Huddart, Nick D James, Ananya Choudhury
BACKGROUND: BC2001 showed combining chemotherapy (5-FU + mitomycin-C) with radiotherapy improves loco-regional disease-free survival in patients with muscle-invasive bladder cancer (MIBC). We previously showed a 24-gene hypoxia-associated signature predicted benefit from hypoxia-modifying radiosensitisation in BCON and hypothesised that only patients with low hypoxia scores (HSs) would benefit from chemotherapy in BC2001. BC2001 allowed conventional (64Gy/32 fractions) or hypofractionated (55Gy/20 fractions) radiotherapy...
March 2024: EBioMedicine
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JOURNAL ARTICLE
Timothy Joseph Lane, Tsan-Hon Liou, Yi-Chia Kung, Philip Tseng, Changwei W Wu
Even when brain scans fail to detect a striate lesion, functional evidence for blindsight can be adduced. In the aftermath of an automobile accident, JK became blind. Results of ophthalmic exams indicated that the blindness must be cortical. Nevertheless, multiple MRI scans failed to detect structural damage to the striate cortex. Prior to the accident JK had been an athlete; after the accident he retained some athletic abilities, arousing suspicions that he might be engaged in fraud. His residual athletic abilities-e...
2024: Frontiers in Neurology
#12
JOURNAL ARTICLE
Zhaorui Wang, Mark D Wishman, Teerapat Tutaworn, Isabelle G Hentschel, Justin E Levin, Joseph M Lane
PURPOSE: Cement usage in total hip arthroplasty (THA) is increasingly common. However, osteoporosis-related fracture risk in cemented vs uncemented THA patients is poorly characterized. We aim to analyze the usage of metabolic bone care and osteoporosis fracture risk in cemented vs uncemented THA patients using FRAX and radiographic bone measurements. METHODS: Chart review on 250 THA patients was performed retrospectively. Demographics, FRAX scores, hip radiograph measurements, osteoporosis diagnosis, treatment and screening were compared between cemented and uncemented THA patients...
February 19, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
#13
REVIEW
Klaus Winter, Joseph A M Holtum
Five decades ago, the first report of a shift from C3 to CAM (crassulacean acid metabolism) photosynthesis following the imposition of stress was published in this journal. The annual, Mesembryanthemum crystallinum (Aizoaceae), was shown to be a C3 plant when grown under non-saline conditions, and a CAM plant when exposed to high soil salinity. This observation of environmentally triggered CAM eventually led to the introduction of the term facultative CAM, which categorises CAM that is induced or upregulated in response to water-deficit stress and is lost or downregulated when the stress is removed...
January 28, 2024: Journal of Plant Physiology
#14
Xiaodan Zhang, Nabasmita Talukdar, Sandeep Vemulapalli, Sumyeong Ahn, Jiankun Wang, Han Meng, Sardar Mehtab Bin Murtaza, Dmitry Leshchiner, Aakash Ajay Dave, Dimitri F Joseph, Martin Witteveen-Lane, Dave Chesla, Jiayu Zhou, Bin Chen
The emerging large language models (LLMs) are actively evaluated in various fields including healthcare. Most studies have focused on established benchmarks and standard parameters; however, the variation and impact of prompt engineering and fine-tuning strategies have not been fully explored. This study benchmarks GPT-3.5 Turbo, GPT-4, and Llama-7B against BERT models and medical fellows' annotations in identifying patients with metastatic cancer from discharge summaries. Results revealed that clear, concise prompts incorporating reasoning steps significantly enhanced performance...
February 8, 2024: medRxiv
#15
JOURNAL ARTICLE
Anna Scaini, Joseph Mulligan, Håkan Berg, Albert Brangarí, Vera Bukachi, Sebastian Carenzo, Da Chau Thi, Colin Courtney-Mustaphi, Anneli Ekblom, Hanne Fjelde, Mathias Fridahl, Anders Hansson, Lettice Hicks, Mattias Höjer, Benard Juma, Jaan-Henrik Kain, Rebecca W Kariuki, Soben Kim, Paul Lane, Ainara Leizeaga, Regina Lindborg, John Livsey, Steve W Lyon, Rob Marchant, Jennifer R McConville, Linus Munishi, David Nilsson, Luke Olang, Stefan Olin, Lennart Olsson, Peter Msumali Rogers, Johannes Rousk, Hans Sandén, Nophea Sasaki, Anna Shoemaker, Benjamin Smith, Lan Thai Huynh Phuong, Ana Varela Varela, Manjunatha Venkatappa, Giulia Vico, Nina Von Uexkull, Christine Wamsler, Menale Wondie, Patrick Zapata, María José Zapata Campos, Stefano Manzoni, Anna Tompsett
Drawing on collective experience from ten collaborative research projects focused on the Global South, we identify three major challenges that impede the translation of research on sustainability and resilience into better-informed choices by individuals and policy-makers that in turn can support transformation to a sustainable future. The three challenges comprise: (i) converting knowledge produced during research projects into successful knowledge application; (ii) scaling up knowledge in time when research projects are short-term and potential impacts are long-term; and (iii) scaling up knowledge across space, from local research sites to larger-scale or even global impact...
February 7, 2024: Ambio
#16
JOURNAL ARTICLE
Jessen V Bredeson, Austin B Mudd, Sofia Medina-Ruiz, Therese Mitros, Owen Kabnick Smith, Kelly E Miller, Jessica B Lyons, Sanjit S Batra, Joseph Park, Kodiak C Berkoff, Christopher Plott, Jane Grimwood, Jeremy Schmutz, Guadalupe Aguirre-Figueroa, Mustafa K Khokha, Maura Lane, Isabelle Philipp, Mara Laslo, James Hanken, Gwenneg Kerdivel, Nicolas Buisine, Laurent M Sachs, Daniel R Buchholz, Taejoon Kwon, Heidi Smith-Parker, Marcos Gridi-Papp, Michael J Ryan, Robert D Denton, John H Malone, John B Wallingford, Aaron F Straight, Rebecca Heald, Dirk Hockemeyer, Richard M Harland, Daniel S Rokhsar
Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate cell and developmental model systems, notably the genus Xenopus. Here we report a high-quality reference genome sequence for the western clawed frog, Xenopus tropicalis, along with draft chromosome-scale sequences of three distantly related emerging model frog species, Eleutherodactylus coqui, Engystomops pustulosus, and Hymenochirus boettgeri. Frog chromosomes have remained remarkably stable since the Mesozoic Era, with limited Robertsonian (i...
January 17, 2024: Nature Communications
#17
JOURNAL ARTICLE
Francesca Scrimieri, Estella Bastian, Mindy Smith, Catherine A Rehm, Caryn Morse, Janaki Kuruppu, Mary McLaughlin, Weizhong Chang, Irini Sereti, Joseph A Kovacs, H Clifford Lane, Hiromi Imamichi
A subset of antiretroviral therapy-treated persons with HIV, referred to as immunological non-responders (INRs), fails to normalize CD4+ T-cell numbers. In a case-control study involving 26 INRs (CD4<250 cells/µL) and 25 immunological responders (IRs, CD4≥250 cells/µL), we evaluated the potential contribution of transcriptionally-competent "defective" HIV-1 proviruses to poor CD4+ T-cell recovery. Compared to the responders, the INRs had higher levels of cell-associated HIV-RNA (p=0.034) and higher percentages of HLA-DR+CD4+ T-cells (p<0...
January 16, 2024: Journal of Infectious Diseases
#18
JOURNAL ARTICLE
Lisa A Mandl, Mangala Rajan, Robyn A Lipschultz, Serena Lian, Dina Sheira, Marianna B Frey, Yvonne M Shea, Joseph M Lane
OBJECTIVES: To evaluate if social isolation or loneliness is associated with outcomes 1 year after low energy hip fracture. DESIGN: Prospective inception cohort study. SETTING: Academic Level I Trauma Center. PATIENT SELECTION CRITERIA: Participants were ≥ 65 years of age and enrolled 2-4 days after surgery for a first low energy hip fracture. Exclusion criteria were bilateral or periprosthetic hip fracture, previous hip fracture, non-English speaking, international address, active cancer, stage 4 cancer in the past 5 years, radiation to the hip region and cognitive impairment...
January 12, 2024: Journal of Orthopaedic Trauma
#19
RANDOMIZED CONTROLLED TRIAL
Peter S Pang, David A Berger, Simon A Mahler, Xiaochun Li, Susan J Pressler, Kathleen A Lane, Jason J Bischof, Douglas Char, Deborah Diercks, Alan E Jones, Erik P Hess, Phillip Levy, Joseph B Miller, Arvind Venkat, Nicholas E Harrison, Sean P Collins
IMPORTANCE: More than 80% of patients who present to the emergency department (ED) with acute heart failure (AHF) are hospitalized. With more than 1 million annual hospitalizations for AHF in the US, safe and effective alternatives are needed. Care for AHF in short-stay units (SSUs) may be safe and more efficient than hospitalization, especially for lower-risk patients, but randomized clinical trial data are lacking. OBJECTIVE: To compare the effectiveness of SSU care vs hospitalization in lower-risk patients with AHF...
January 2, 2024: JAMA Network Open
#20
JOURNAL ARTICLE
Andrew Joseph Carter, Jad Raffoul, Linden Lane, Leah LeSage, Shelley Langenhorst, Matthew Smolin, Michael Dempsey, David Hughes, Michael Gleason, Steven Weiss, William D Anderson
INTRODUCTION: Cardiogenic shock (CS) complicates 5%-15% of cases of acute myocardial infarction (AMI) with inpatient mortality greater than 40%. The implementation of standardised protocols may improve clinical outcomes in patients with AMI-CS. METHODS AND ANALYSIS: The Durango model is a prospective single-centre registry designed to enable early identification of patients with STEMI-CS to facilitate primary reperfusion therapy with a shock team management algorithm in a rural level II heart attack centre...
December 7, 2023: Open Heart
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