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Joseph Lane

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https://www.readbyqxmd.com/read/29778037/efficient-electrochemical-degradation-of-multiwall-carbon-nanotubes
#1
Vytas Reipa, Shannon K Hanna, Aaron Urbas, Lane Sander, John Elliott, Joseph Conny, Elijah J Petersen
As the production mass of multiwall carbon nanotubes (MWCNT) increases, the potential for human and environmental exposure to MWCNTs may also increase. We have shown that exposing an aqueous suspension of pristine MWCNTs to an intense oxidative treatment in an electrochemical reactor, equipped with an efficient hydroxyl radical generating Boron Doped Diamond (BDD) anode, leads to their almost complete mineralization. Thermal optical transmittance analysis showed a total carbon mass loss of over two orders of magnitude due to the electrochemical treatment, a result consistent with measurements of the degraded MWCNT suspensions using UV-vis absorbance...
April 26, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29750786/correction-single-trait-and-multi-trait-genome-wide-association-analyses-identify-novel-loci-for-blood-pressure-in-african-ancestry-populations
#2
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
[This corrects the article DOI: 10.1371/journal.pgen.1006728.].
May 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29701926/associations-between-lean-mass-muscle-strength-and-power-and-skeletal-size-density-and-strength-in-older-men
#3
Didier Chalhoub, Robert Boudreau, Susan Greenspan, Anne B Newman, Joseph Zmuda, Andrew W Frank-Wilson, Nayana Nagaraj, Andrew R Hoffman, Nancy E Lane, Marcia L Stefanick, Elizabeth Barrett-Connor, Tien Dam, Peggy Cawthon, Eric Orwoll, Jane A Cauley
Studies examining the relationship between muscle parameters and bone strength have not included multiple muscle measurements and/or both central and peripheral skeletal parameters. The purpose of this study was to explore the relationship between lean mass, muscle strength and power, and skeletal size, bone density and bone strength. We studied the association between appendicular lean mass (ALM), grip strength and leg power, and central quantitative computed tomography (QCT) parameters in 2,857 men aged 65 or older; peripheral QCT was available on a subset (N = 786)...
April 27, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29660039/trial-readiness-in-cavernous-angiomas-with-symptomatic-hemorrhage-cash
#4
Sean P Polster, Ying Cao, Timothy Carroll, Kelly Flemming, Romuald Girard, Daniel Hanley, Nicholas Hobson, Helen Kim, James Koenig, Janne Koskimäki, Karen Lane, Jennifer J Majersik, Nichol McBee, Leslie Morrison, Robert Shenkar, Agnieszka Stadnik, Richard E Thompson, Joseph Zabramski, Hussein A Zeineddine, Issam A Awad
BACKGROUND: Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent bleeding, for which there is no proven therapy. Candidate drugs to stabilize the CASH lesion and prevent rebleeding will ultimately require testing of safety and efficacy in multisite clinical trials. Much progress has been made in understanding the epidemiology of CASH, and novel biomarkers have been linked to the biological mechanisms and clinical activity in lesions...
April 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29605381/type-2-diabetes-patients-have-accelerated-cartilage-matrix-degeneration-compared-to-diabetes-free-controls-data-from-the-osteoarthritis-initiative
#5
Jan Neumann, Felix C Hofmann, Ursula Heilmeier, Walid Ashmeik, Kenneth Tang, Alexandra S Gersing, Benedikt J Schwaiger, Michael C Nevitt, Gabby B Joseph, Nancy E Lane, Charles E McCulloch, Thomas M Link
PURPOSE: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. METHODS: From the Osteoarthritis Initiative cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren-Lawrence score with 196 non-diabetic controls...
March 29, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29593979/the-association-between-pre-hospital-antibiotic-therapy-and-subsequent-in-hospital-mortality-in-adults-presenting-with-community-acquired-pneumonia-an-observational-study
#6
Biswajit Chakrabarti, Dan Wootton, Steven Lane, Elizabeth Kanwar, Joseph Somers, Jacyln Proctor, Nancy Prospero, Mark Woodhead
Background: The majority of patients with community acquired-pneumonia (CAP) are treated in primary care and the mortality in this group is very low. However, a small but significant proportion of patients who begin treatment in the community subsequently require admission due to symptomatic deterioration. This study compared patients who received community antibiotics prior to admission to those who had not, and looked for associations with clinical outcomes. Methods: This study analysed the Advancing Quality (AQ) Pneumonia database of patients admitted with CAP to 9 acute hospitals in the northwest of England over a 12-month period...
2018: Pneumonia
https://www.readbyqxmd.com/read/29590443/the-neurophysiological-basis-of-the-discrepancy-between-objective-and-subjective-sleep-during-the-sleep-onset-period-an-eeg-fmri-study
#7
Fan-Chi Hsiao, Pei-Jung Tsai, Timothy Joseph Lane, Changwei W Wu, Hsin-Chien Lee, Ling-Chun Chen, We-Kang Lee, Lu-Hsin Lu, Yu-Zu Wu, Chien-Ming Yang
Subjective perception of sleep is not necessarily consistent with EEG indications of sleep. The mismatch between subjective reports and objective measures is often referred to as "sleep state misperception" (SSM). Previous studies evince that this mismatch is found in both insomnia patients and in normal sleepers, but the neurophysiological mechanism remains unclear. The aim of the study is to explore the neurophysiological basis of this mechanism, from the perspective of both EEG power and fMRI fluctuations...
March 24, 2018: Sleep
https://www.readbyqxmd.com/read/29564850/consensus-statement-feature-and-function-recommendations-to-optimize-clinician-usability-of-direct-interoperability-to-enhance-patient-care
#8
Steven R Lane, Holly Miller, Elizabeth Ames, Lawrence Garber, David C Kibbe, Joseph H Schneider, Christoph U Lehmann
BACKGROUND: Secure clinical messaging and document exchange utilizing the Direct Protocol (Direct interoperability) has been widely implemented in health information technology (HIT) applications including electronic health records (EHRs) and by health care providers and organizations in the United States. While Direct interoperability has allowed clinicians and institutions to satisfy regulatory requirements and has facilitated communication and electronic data exchange as patients transition across care environments, feature and function enhancements to HIT implementations of the Direct Protocol are required to optimize the use of this technology...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29510346/age-and-other-risk-factors-related-to-reentry-to-care-from-kin-guardian-homes
#9
Arno Parolini, Aron Shlonsky, Joseph Magruder, Andrea Lane Eastman, Fred Wulczyn, Daniel Webster
Although kinship guardianship is an increasingly important foster care exit pathway for children in the United States, research on the factors leading to kinship guardianship breakdown is lacking. This study examines the factors associated with guardianship breakdown for children who exited foster care to kinship guardianship in California between 2003 and 2010 (N = 18,831). Specifying time-dependent Cox relative risk models, children's age trajectories are directly accounted for in the analysis. This allows differentiation between duration dependence (i...
May 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29471726/exploring-dual-disclosures-for-men-who-have-sex-with-men-in-mpumalanga-south-africa-a-report-from-the-field
#10
Joseph Daniels, Tim Lane, Kabelo Maleke, Wini Mogos, Ryan Assaf, Helen Struthers, James McIntyre, Tom Coates
We explored to whom rural men who have sex with men (MSM) disclose their sexual identity and HIV status in Mpumalanga, South Africa. Participants were recruited using a modified snowball sampling method in order to complete a questionnaire. Descriptive and logistic regression analyses were conducted. There were 47 participants of whom 22 self-reported as HIV-positive. Most participants disclosed their sexuality and HIV status to immediate family members and gay-identified friends. We found that the longer someone had identified as MSM, the more likely they were to be HIV-positive and not go to clinic...
March 2018: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#11
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29358052/lipids-shape-the-electron-acceptor-binding-site-of-the-peripheral-membrane-protein-dihydroorotate-dehydrogenase
#12
Joana Costeira-Paulo, Joseph Gault, Gergana Popova, Marcus J G W Ladds, Ingeborg M M van Leeuwen, Médoune Sarr, Anders Olsson, David P Lane, Sonia Laín, Erik G Marklund, Michael Landreh
The interactions between proteins and biological membranes are important for drug development, but remain notoriously refractory to structural investigation. We combine non-denaturing mass spectrometry (MS) with molecular dynamics (MD) simulations to unravel the connections among co-factor, lipid, and inhibitor binding in the peripheral membrane protein dihydroorotate dehydrogenase (DHODH), a key anticancer target. Interrogation of intact DHODH complexes by MS reveals that phospholipids bind via their charged head groups at a limited number of sites, while binding of the inhibitor brequinar involves simultaneous association with detergent molecules...
March 15, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29348869/role-of-the-n-terminal-lid-in-regulating-the-interaction-of-phosphorylated-mdmx-with-p53
#13
Jane Vin Chan, Dawn Xin Ping Koh, Yun Liu, Thomas L Joseph, David P Lane, Chandra S Verma, Yaw Sing Tan
Murine double minute 4 protein (MDMX) is crucial for the regulation of the tumor suppressor protein p53. Phosphorylation of the N-terminal domain of MDMX is thought to affect its binding with the transactivation domain of p53, thus playing a role in p53 regulation. In this study, the effects of MDMX phosphorylation on the binding of p53 were investigated using molecular dynamics simulations. It is shown that in addition to the previously proposed mechanism in which phosphorylated Y99 of MDMX inhibits p53 binding through steric clash with P27 of p53, the N-terminal lid of MDMX also appears to play an important role in regulating the phosphorylation-dependent interactions between MDMX and p53...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29198854/efficacy-and-safety-of-transversus-abdominis-plane-blocks-versus-thoracic-epidural-anesthesia-in-patients-undergoing-major-abdominal-oncologic-resections-a-prospective-randomized-controlled-trial
#14
Tamer M Shaker, Joseph T Carroll, Mathew H Chung, Tracy J Koehler, Brian R Lane, Andrea M Wolf, G Paul Wright
BACKGROUND: The purpose of this study was to compare patient outcomes for thoracic epidural anesthesia (TEA) with transversus abdominis plane (TAP) blocks. METHODS: A prospective, randomized trial was performed for patients undergoing abdominal oncologic surgeries. RESULTS: There were 32 TAP and 35 TEA subjects. The TEA group demonstrated increased episodes of hypotension in the first 24 h (3 v 0.6, p = 0.02). There was no difference in 24-48 h fluid balance between the groups...
March 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29168662/how-social-stigma-sustains-the-hiv-treatment-gap-for-msm-in-mpumalanga-south-africa
#15
Kabelo Maleke, Joseph Daniels, Tim Lane, Helen Struthers, James McIntyre, Thomas Coates
There are gaps in HIV care for men who have sex with men (MSM) in African settings, and HIV social stigma plays a significant role in sustaining these gaps. We conducted a three-year research project with 49 HIV-positive MSM in two districts in Mpumalanga Province, South Africa, to understand the factors that inform HIV care seeking behaviors. Semi-structured focus group discussions and interviews were conducted in IsiZulu, SiSwati, and some code-switching into English, and these were audio-recorded, transcribed, and translated into English...
November 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/29152838/commissioning-of-the-world-s-first-compact-pencil-beam-scanning-proton-therapy-system
#16
Rajesh Pidikiti, Bijal C Patel, Matthew R Maynard, Joseph P Dugas, Joseph Syh, Narayan Sahoo, Hsinshun Terry Wu, Lane R Rosen
This paper summarizes clinical commissioning of the world's first commercial, clinically utilized installation of a compact, image-guided, pencil-beam scanning, intensity-modulated proton therapy system, the IBA Proteus® ONE, at the Willis-Knighton Cancer Center (WKCC) in Shreveport, LA. The Proteus® ONE is a single-room, compact-gantry system employing a cyclotron-generated proton beam with image guidance via cone-beam CT as well as stereoscopic orthogonal and oblique planar kV imaging. Coupling 220° of gantry rotation with a 6D robotic couch capable of in plane patient rotations of over 180° degrees allows for 360° of treatment access...
January 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29143404/tool-for-osteoarthritis-risk-prediction-toarp-over-8-years-using-baseline-clinical-data-x-ray-and-mri-data-from-the-osteoarthritis-initiative
#17
Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, Jan Neumann, Alexandra S Gersing, Martin Kretzschmar, Benedikt J Schwaiger, John A Lynch, Ursula Heilmeier, Nancy E Lane, Thomas M Link
BACKGROUND: Osteoarthritis (OA), a multifactorial disease causing joint degeneration, often leads to severe disability. The rising rates of disability highlight the need for implementing preventative measures at early stages of the disease, which would especially benefit subjects at high risk for OA development. PURPOSE: To develop a risk prediction tool for moderate-severe OA (TOARP) over 8 years based on subject characteristics, knee radiographs, and MRI data at baseline using data from the Osteoarthritis Initiative (OAI)...
November 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29112594/sexual-activity-and-vaginal-symptoms-in-the-postintervention-phase-of-the-women-s-health-initiative-hormone-therapy-trials
#18
Margery Gass, Joseph Larson, Barbara Cochrane, JoAnn E Manson, Dorothy Lane, Vanessa Barnabei, Judith Ockene, Marcia L Stefanick, Charles Mouton
OBJECTIVE: To assess the impact of discontinuing oral hormone therapy (HT) on sexual activity, vaginal symptoms, and sexual activity components among participants in the estrogen-progestin therapy (EPT) and estrogen therapy (ET) trial of the Women's Health Initiative. METHODS: Surveys were sent postintervention to those who were still taking study pills and agreed to continue in the study when the trials were stopped. Comparisons between former HT and placebo users were accomplished with chi-square tests for categorical variables and t tests for continuous variables...
March 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29059109/metabolic-bone-diseases-and-total-hip-arthroplasty-preventing-complications
#19
REVIEW
Joaquin Moya-Angeler, Joseph M Lane, Jose A Rodriguez
Metabolic bone diseases are a diverse group of conditions characterized by abnormalities in calcium metabolism and/or bone cell physiology. These unbalanced processes can eventually lead to bony deformities and altered joint biomechanics, resulting in degenerative joint disease. Not infrequently, patients with metabolic bone diseases have restricting hip joint pain that ultimately necessitates hip arthroplasty. To minimize complications, the surgeon must consider the particular characteristics of these patients...
November 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29021218/transcriptomic-analysis-of-octanoic-acid-response-in-drosophila-sechellia-using-rna-sequencing
#20
Stephen M Lanno, Sara M Gregory, Serena J Shimshak, Maximilian K Alverson, Kenneth Chiu, Arden L Feil, Morgan G Findley, Taylor E Forman, Julia T Gordon, Josephine Ho, Joanna L Krupp, Ivy Lam, Josh Lane, Samuel C Linde, Ashley E Morse, Serena Rusk, Robie Ryan, Avva Saniee, Ruchi B Sheth, Jennifer J Siranosian, Lalitpatr Sirichantaropart, Sonya R Sternlieb, Christina M Zaccardi, Joseph D Coolon
The dietary specialist fruit fly Drosophila sechellia has evolved to specialize on the toxic fruit of its host plant Morinda citrifolia Toxicity of Morinda fruit is primarily due to high levels of octanoic acid (OA). Using RNA interference (RNAi), prior work found that knockdown of Osiris family genes Osiris 6 ( Osi6 ), Osi7 , and Osi8 led to increased susceptibility to OA in adult D. melanogaster flies, likely representing genes underlying a Quantitative Trait Locus (QTL) for OA resistance in D. sechellia While genes in this major effect locus are beginning to be revealed, prior work has shown at least five regions of the genome contribute to OA resistance...
December 4, 2017: G3: Genes—Genomes—Genetics
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