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Joseph Lane

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https://www.readbyqxmd.com/read/28763418/tracking-cumulative-radiation-exposure-in-orthopaedic-surgeons-and-residents-what-dose-are-we-getting
#1
Elizabeth B Gausden, Alexander B Christ, Roseann Zeldin, Joseph M Lane, Moira M McCarthy
BACKGROUND: The purpose of this study was to determine the amount of cumulative radiation exposure received by orthopaedic surgeons and residents in various subspecialties. We obtained dosimeter measures over 12 months on 24 residents and 16 attending surgeons. METHODS: Monthly radiation exposure was measured over a 12-month period for 24 orthopaedic residents and 16 orthopaedic attending surgeons. The participants wore a Landauer Luxel dosimeter on the breast pocket of their lead apron...
August 2, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28760963/atypical-fracture-with-long-term-bisphosphonate-therapy-is-associated-with-altered-cortical-composition-and-reduced-fracture-resistance
#2
Ashley A Lloyd, Bernd Gludovatz, Christoph Riedel, Emma A Luengo, Rehan Saiyed, Eric Marty, Dean G Lorich, Joseph M Lane, Robert O Ritchie, Björn Busse, Eve Donnelly
Bisphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis and reduce fracture risk in postmenopausal women by up to 50%. However, in the past decade these drugs have been associated with atypical femoral fractures (AFFs), rare fractures with a transverse, brittle morphology. The unusual fracture morphology suggests that bisphosphonate treatment may impair toughening mechanisms in cortical bone. The objective of this study was to compare the compositional and mechanical properties of bone biopsies from bisphosphonate-treated patients with AFFs to those from patients with typical osteoporotic fractures with and without bisphosphonate treatment...
July 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28758564/do-medical-residents-perform-patient-centered-medical-home-tasks-a-mixed-methods-study
#3
Lauren Block, Nancy LaVine, Jennifer Verbsky, Ankita Sagar, Miriam A Smith, Susan Lane, Joseph Conigliaro, Saima A Chaudhry
BACKGROUND: Increasingly, residents are being trained in Patient-centered Medical Home (PCMH) settings. A set of PCMH entrustable professional activities (EPAs) for residents has been defined but not evaluated in practice. OBJECTIVE: To understand whether residents trained at PCMH sites reported higher likelihood of engaging in PCMH tasks than those training in non-PCMH sites. DESIGN: Survey and nominal group data from post-graduate trainees at three residency programs...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28741468/development-of-standard-reference-material-srm-2973-vitamin-d-metabolites-in-frozen-human-serum-high-level
#4
Susan Tai, Michael Nelson, Mary Bedner, Brian Lang, Karen Phinney, Lane Sander, James Yen, Joseph Betz, Christopher Sempos, Stephen Wise
The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health Office of Dietary Supplements and the Vitamin D Standardization Program, has recently issued a new serum-matrix Standard Reference Material (SRM): 2973 Vitamin D Metabolites in Frozen Human Serum (High Level). SRM 2973 was designed to provide a serum material with a total 25-hydroxyvitamin D [25(OH)D] concentration near 100 nmol/L to complement the existing serum-based SRMs with values assigned for total 25(OH)D between 20 and 80 nmol/L...
July 24, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28623654/value-assignment-of-vitamin-d-metabolites-in-vitamin-d-standardization-program-serum-samples
#5
Karen W Phinney, Johanna E Camara, Susan S-C Tai, Lane C Sander, Stephen A Wise, Linde A C De Grande, Linda M Thienpont, Antonio M Possolo, Blaza Toman, Christopher T Sempos, Joseph M Betz, Paul M Coates
Assay variability has been cited as an obstacle to establishing optimal vitamin D exposure. As part of the Vitamin D Standardization Program (VDSP) effort to standardize the measurement of total 25-hydroxyvitamin D [25(OH)D], the value assignment of total 25(OH)D in 50 single-donor serum samples was performed using two isotope-dilution LC with tandem MS methods. Both methods are recognized as reference measurement procedures (RMPs) by the Joint Committee for Traceability in Laboratory Medicine. These samples and their assigned values serve as the foundation for several aspects of the VDSP...
June 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28623114/characterizing-the-relationship-between-surgical-resident-and-faculty-perceptions-of-autonomy-in-the-operating-room
#6
Katelyn A Young, Samantha M Lane, John E Widger, Nina M Neuhaus, James T Dove, Marcus Fluck, Marie A Hunsinger, Joseph A Blansfield, Mohsen M Shabahang
OBJECTIVE: Characterize the concordance among faculty and resident perceptions of surgical case complexity, resident technical performance, and autonomy in a diverse sample of general surgery procedures using case-specific evaluations. DESIGN: A prospective study was conducted in which a faculty surgeon and surgical resident independently completed a postoperative assessment examining case complexity, resident operative performance (Milestone assessment) and autonomy (Zwisch model)...
June 13, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28610546/neuromuscular-electrical-stimulation-for-the-prevention-of-venous-thromboembolism
#7
Raveena Ravikumar, Katherine J Williams, Adarsh Babber, Hayley M Moore, Tristan Ra Lane, Joseph Shalhoub, Alun H Davies
Objective Venous thromboembolism, encompassing deep vein thrombosis and pulmonary embolism, is a significant cause of morbidity and mortality, affecting one in 1000 adults per year. Neuromuscular electrical stimulation is the transcutaneous application of electrical impulses to elicit muscle contraction, preventing venous stasis. This review aims to investigate the evidence underlying the use of neuromuscular electrical stimulation in thromboprophylaxis. Methods The Medline and Embase databases were systematically searched, adhering to PRISMA guidelines, for articles relating to electrical stimulation and thromboprophylaxis...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28604576/diagnosing-large-vestibular-aqueduct-radiological-review-of-high-resolution-ct-versus-high-resolution-volumetric-mri
#8
Nicholas L Deep, Matthew L Carlson, Steven M Weindling, David M Barrs, Colin L W Driscoll, Christine M Lohse, John I Lane, Joseph M Hoxworth
OBJECTIVES: To compare the diagnostic yield of high-resolution volumetric T2-weighted MRI (HRT2-MRI) with high-resolution computed tomography (HRCT) for diagnosis of large vestibular aqueduct (LVA). STUDY DESIGN: Three board-certified neuroradiologists performed an independent, blinded radiological review for diagnosing LVA with 2:1 age-matched controls on patients with both HRCT and HRT2-MRI imaging. SETTING: Tertiary referral center. PATIENTS: All patients between 2002 and 2016 with hearing loss who underwent both HRCT and HRT2-MRI and were diagnosed with LVA on either modality...
August 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28556419/association-of-diabetes-mellitus-and-biochemical-knee-cartilage-composition-assessed-by-t2-relaxation-time-measurements-data-from-the-osteoarthritis-initiative
#9
Nattagan Chanchek, Alexandra S Gersing, Benedikt J Schwaiger, Michael C Nevitt, Jan Neumann, Gabby B Joseph, Nancy E Lane, Julia Zarnowski, Felix C Hofmann, Ursula Heilmeier, Charles E McCulloch, Thomas M Link
PURPOSE: To investigate the association of the presence and severity of diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)-based T2 relaxation time measurements, and structural knee abnormalities. MATERIALS AND METHODS: In the Osteoarthritis Initiative 208, participants with DM (age 63.0 ± 8.9 years; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren-Lawrence [KL] grade ≤2) were identified and group-matched with 208 controls without DM (age 63...
May 26, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28498854/single-trait-and-multi-trait-genome-wide-association-analyses-identify-novel-loci-for-blood-pressure-in-african-ancestry-populations
#10
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28490123/kinetics-of-conversion-of-dihydroxyacetone-to-methylglyoxal-in-new-zealand-m%C3%A4-nuka-honey-part-iv-formation-of-hmf
#11
Megan N C Grainger, Adrian Owens, Merilyn Manley-Harris, Joseph R Lane, Richard J Field
During a study of the conversion of dihydroxyacetone (DHA) to methylglyoxal (MGO) in maturing New Zealand mānuka honey, the kinetics of formation of 5-(hydroxymethyl)furfural (HMF) was studied at temperatures from 4 to 37°C. Formation of HMF was first-order during an induction period and zero-order thereafter indicating that the mechanism includes the formation of certain critical intermediates and that these require time to build up; the duration of the induction period depended primarily upon temperature...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28445186/the-hip-fracture-patient-on-warfarin-evaluating-blood-loss-and-time-to-surgery
#12
Matthew R Cohn, Ashley E Levack, Nikunj N Trivedi, Jordan C Villa, David S Wellman, John P Lyden, Dean G Lorich, Joseph M Lane
OBJECTIVES: To compare blood loss, delay of surgery, and short-term adverse events in (1) patients admitted on warfarin versus nonanticoagulated controls and (2) warfarin patients with day of surgery (DOS) international normalized ratio (INR) of 1.5 or greater versus below 1.5. DESIGN: Retrospective cohort. SETTING: Academic Level I trauma center. PATIENTS/PARTICIPANTS: One hundred twenty four patients treated surgically for hip fractures including patients presenting on warfarin (n = 62) and matched controls (n = 62)...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28437188/further-characterization-of-the-mitigation-of-radiation-lethality-by-protective-wounding
#13
Joseph R Dynlacht, Joy Garrett, Rebecca Joel, Katharina Lane, Marc S Mendonca, Christie M Orschell
There continues to be a major effort in the United States to develop mitigators for the treatment of mass casualties that received high-intensity acute ionizing radiation exposures from the detonation of an improvised nuclear device during a radiological terrorist attack. The ideal countermeasure should be effective when administered after exposure, and over a wide range of absorbed doses. We have previously shown that the administration of a subcutaneous incision of a defined length, if administered within minutes after irradiation, protected young adult female C57BL/6 mice against radiation-induced lethality, and increased survival after total-body exposure to an LD50/30 X-ray dose from 50% to over 90%...
June 2017: Radiation Research
https://www.readbyqxmd.com/read/28436672/kinetic-energy-density-as-a-predictor-of-hydrogen-bonded-oh-stretching-frequencies
#14
Joseph R Lane, Anne S Hansen, Kasper Mackeprang, Henrik G Kjaergaard
This work considers the nature of the intermolecular hydrogen bond in a series of 15 different complexes with OH donor groups and N, O, P, or S acceptor atoms. To complement the existing literature, room-temperature gas-phase vibrational spectra of the methanol-pyridine, ethanol-pyridine, and 2,2,2-trifluoroethanol-pyridine complexes were recorded. These complexes were chosen, as they exhibit hydrogen bonds of intermediate strength as compared to previous investigations that involved strong or weak hydrogen bonds...
May 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28426267/a-phase-2-trial-of-single-agent-axitinib-as-maintenance-therapy-following-first-line-treatment-with-modified-folfox-bevacizumab-in-patients-with-metastatic-colorectal-cancer
#15
Johanna C Bendell, Mathew Joseph, Kirk Barnes, Mark Mainwaring, Dianna Shipley, Chandra Reddy, Laura Blakely, Ronald Blachly, Cassie M Lane, Chris Earwood, Michel Kuzur
This phase-2 trial evaluated the efficacy of axitinib as maintenance therapy for patients with metastatic colorectal cancer (mCRC) following first-line treatment with FOLFOX/bevacizumab. Patients with mCRC received mFOLFOX/bevacizumab followed by axitinib maintenance after four cycles. The primary endpoint was progression-free survival (PFS). Seventy patients were enrolled. Common treatment-related toxicities were fatigue, nausea, diarrhea, and peripheral neuropathy during FOLFOX/bevacizumab treatment; and fatigue, hypertension, diarrhea, and peripheral neuropathy during axitinib treatment...
July 3, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28413336/a-restatement-of-the-natural-science-evidence-concerning-catchment-based-natural-flood-management-in-the-uk
#16
REVIEW
Simon J Dadson, Jim W Hall, Anna Murgatroyd, Mike Acreman, Paul Bates, Keith Beven, Louise Heathwaite, Joseph Holden, Ian P Holman, Stuart N Lane, Enda O'Connell, Edmund Penning-Rowsell, Nick Reynard, David Sear, Colin Thorne, Rob Wilby
Flooding is a very costly natural hazard in the UK and is expected to increase further under future climate change scenarios. Flood defences are commonly deployed to protect communities and property from flooding, but in recent years flood management policy has looked towards solutions that seek to mitigate flood risk at flood-prone sites through targeted interventions throughout the catchment, sometimes using techniques which involve working with natural processes. This paper describes a project to provide a succinct summary of the natural science evidence base concerning the effectiveness of catchment-based 'natural' flood management in the UK...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28406804/subjective-general-health-and-the-social-regulation-of-hypothalamic-activity
#17
Casey L Brown, Lane Beckes, Joseph P Allen, James A Coan
OBJECTIVE: Social support is associated with better health. This association may be partly mediated through the social regulation of adrenomedullary activity related to poor cardiovascular health and glucocorticoid activity known to inhibit immune functioning. These physiological cascades originate in the hypothalamic areas that are involved in the neural response to threat. The aim of the study investigated whether the down regulation, by social support, of hypothalamic responses to threat is associated with better subjective health...
July 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28375002/development-of-an-improved-standard-reference-material-for-vitamin-d-metabolites-in-human-serum
#18
Karen W Phinney, Susan S-C Tai, Mary Bedner, Johanna E Camara, Rosalind R C Chia, Lane C Sander, Katherine E Sharpless, Stephen A Wise, James H Yen, Rosemary L Schleicher, Madhulika Chaudhary-Webb, Khin L Maw, Yasamin Rahmani, Joseph M Betz, Joyce Merkel, Christopher T Sempos, Paul M Coates, Ramón A Durazo-Arvizu, Kurtis Sarafin, Stephen P J Brooks
The National Institute of Standards and Technology (NIST) has developed Standard Reference Material (SRM) 972a Vitamin D Metabolites in Frozen Human Serum as a replacement for SRM 972, which is no longer available. SRM 972a was developed in collaboration with the National Institutes of Health's Office of Dietary Supplements. In contrast to the previous reference material, three of the four levels of SRM 972a are composed of unmodified human serum. This SRM has certified and reference values for the following 25-hydroxyvitamin D [25(OH)D] species: 25(OH)D2, 25(OH)D3, and 3-epi-25(OH)D3...
April 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28367747/hiv-risk-and-prevention-among-men-who-have-sex-with-men-in-rural-south-africa
#19
Kabelo Maleke, Nosipho Makhakhe, Remco Ph Peters, Geoffrey Jobson, Glenn De Swardt, Joseph Daniels, Timothy Lane, James A McIntyre, John Imrie, Helen Struthers
Rural South African men who have sex with men (MSM) are likely to be underserved in terms of access to relevant healthcare and HIV prevention services. While research in urban and peri-urban MSM populations has identified a range of factors affecting HIV risk in South African MSM, very little research is available that examines HIV risk and prevention in rural MSM populations. This exploratory study begins to address this lack by assessing perceptions of HIV risk among MSM in rural Limpopo province. Using thematic analysis of interview and discussion data, two overarching global themes that encapsulated participants' understandings of HIV risk and the HIV risk environment in their communities were developed...
March 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28359100/response-to-pd-miller-underdiagnosis-and-undertreatment-of-osteoporosis-the-battle-to-be-won
#20
David B Burr, Joseph E Lane, Tet Sen Howe, Alvin C Ng, Peter R Ebeling
No abstract text is available yet for this article.
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
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