keyword
MENU ▼
Read by QxMD icon Read
search

Thiazid

keyword
https://www.readbyqxmd.com/read/28197292/chlorthalidone-plus-amiloride-reduces-the-central-systolic-blood-pressure-in-stage-1-hypertension-patients
#1
Leticia Aparecida Barufi Fernandes, Elizabeth do Espirito Santo Cestario, Luciana Neves Cosenso-Martin, Jose Fernando Vilela-Martin, Juan Carlos Yugar-Toledo, Flavio Danni Fuchs
BACKGROUND: Hypertension reduction strategies use blood pressure in the brachial artery as the primary endpoint. Individuals who achieve the target blood pressure reduction with antihypertensive treatment have residual cardiovascular risk attributed to the difference in pressure between the aorta and brachial artery. Antihypertensive treatment affects the intrinsic properties of the vascular wall and arterial stiffness markers and consequently the central pressure. Recent publications stress the importance of adequate control of the central compared to peripheral blood pressure...
December 2016: Cardiology Research
https://www.readbyqxmd.com/read/28182047/hyponatremia-a-rare-complication-of-gitelman-s-syndrome
#2
A Ganguli, J H Veis
Gitelman's syndrome (GS) is a rare autosomal recessive disorder caused by mutations in thiazide-sensitive NaCl cotransporter. We report a 49-year-old, normotensive lady with prolonged hypokalemia since her 20s who was diagnosed with GS at our renal clinic. During follow-up, she was found to have mild, asymptomatic, euvolemic hyponatremia with low serum uric acid, inappropriately high urine osmolality and sodium consistent with syndrome of inappropriate antidiuretic hormone-like presentation. Despite life-long urinary sodium losses, hyponatremia has rarely been reported in GS to be due to the primary disease process...
January 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28177101/-severe-hyperkalemia-in-patients-referred-to-an-emergency-departement-the-role-of-antialdosterone-drugs-and-of-renin-angiotensin-system-blockers
#3
Daria Motta, Giulio Cesano, Angelo Pignataro, Roberto Boero
We analyzed the clinical features and the factors associated with the presence of hyperkalemia (serum potassium >5.3 mmol/L) in a cohort of patients presenting to an Emergency Department. A total of 168 cases were observed (89 males and 79 females), mean age 77.512 years. Fifty-six patients were diabetics (33.3%), 51 patients had chronic kidney disease (30%) and 36 patients with cardiac failure (21.4%). Sixty-nine patients (41%) were treated with RAS-blockers (ACE-I n = 50; ARBs, n = 19). 65 subjects were taking loop diuretics (39%), 17 (10%) thiazides...
January 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28174181/cardiovascular-benefits-associated-with-higher-dietary-k-versus-lower-dietary-na-evidence-from-population-and-mechanistic-studies
#4
Alicia A McDonough, Luciana C Veiras, Claire A Guevara, Donna L Ralph
The WHO ranks hypertension the leading global risk factor for disease, specifically, cardiovascular disease. Blood pressure is higher in westernized populations consuming sodium-rich processed foods compared to isolated societies consuming potassium-rich natural foods. Evidence suggests that lowering dietary Na(+) is particularly beneficial in hypertensives who consume a high Na(+) diet. Nonetheless, numerous population studies demonstrate a relationship between higher dietary K(+), estimated from urinary excretion or dietary recall, and lower blood pressure regardless of sodium intake...
February 7, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28148559/risk-of-hypertension-among-first-time-symptomatic-kidney-stone-formers
#5
Wonngarm Kittanamongkolchai, Kristin C Mara, Ramila A Mehta, Lisa E Vaughan, Aleksandar Denic, John J Knoedler, Felicity T Enders, John C Lieske, Andrew D Rule
BACKGROUND AND OBJECTIVES: Prior work has suggested a higher risk of hypertension in kidney stone formers but lacked disease validation and adjustment for potential confounders. Certain types of stone formers may also be at higher risk of hypertension. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In our study, incident symptomatic stone formers in Olmsted County from 2000 to 2011 were manually validated by chart review and age and sex matched to Olmsted County controls...
February 1, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28121841/thiazide-diuretics-and-fracture-in-patients-with-hypertension
#6
Tomoyuki Kawada
No abstract text is available yet for this article.
March 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28118450/thiazide-diuretics-protect-bones-as-well-as-hearts
#7
Anita Slomski
No abstract text is available yet for this article.
January 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28115488/genome-wide-prioritization-and-transcriptomics-reveal-novel-signatures-associated-with-thiazide-diuretics-blood-pressure-response
#8
Mohamed H Shahin, Ana C Sá, Amy Webb, Yan Gong, Taimour Langaee, Caitrin W McDonough, Alberto Riva, Amber L Beitleshees, Arlene B Chapman, John G Gums, Stephen T Turner, Eric Boerwinkle, Steven E Scherer, Wolfgang Sadee, Rhonda M Cooper-DeHoff, Julie A Johnson
BACKGROUND: Thiazide diuretics are among the most commonly prescribed antihypertensives. However, <50% of thiazide-treated patients achieve blood pressure (BP) control. Herein, we used different omics (genomics and transcriptomics) to identify novel biomarkers of thiazide diuretics BP response. METHODS AND RESULTS: Genome-wide analysis included 228 white hypertensives with BP determined at baseline and after 9 weeks of hydrochlorothiazide. Single-nucleotide polymorphisms with P <5×10(-)(5) were prioritized according to their biological function, using RegulomeDB, haploreg, and Genome-Wide Annotation of Variants...
January 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28106027/-all-diuretics-used-in-the-treatment-of-hypertension-are-not-the-same
#9
Serkan Asil, Enver Atalar
Diuretics have been used for years to treat hypertension as both a monotherapy and in combination. Hydrochlorothiazide, indapamide, and chlorthalidone have frequently been considered in the same category as thiazide diuretics, but there is no evidence that their activities are similar. Studies have shown that chlorthalidone and indapamide reduce cardiovascular morbidity and mortality; however, there is no study indicating that hydrochlorothiazide has beneficial effects on cardiovascular outcomes such as myocardial infarction, renal failure, stroke, or death...
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28104972/utilization-study-of-antihypertensives-in-a-south-indian-tertiary-care-teaching-hospital-and-adherence-to-standard-treatment-guidelines
#10
Supratim Datta
AIM: Hypertension represents a major health problem primarily because of its role in contributing to the initiation and progression of major cardiovascular diseases. Concerns pertaining to hypertension and its sequelae can be substantially addressed and consequent burden of disease reduced by early detection and appropriate therapy of elevated blood pressure. This cross-sectional observational study aims at analyzing the utilization pattern of antihypertensives used for the treatment of hypertension at a tertiary care hospital in perspective of standard treatment guidelines...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28102885/profound-hyponatraemia-in-the-emergency-department-seasonality-and-risk-factors
#11
Tibor Huwyler, Jerome Stirnemann, Nicolas Vuilleumier, Christophe Marti, Sarah Dugas, Pierre-Alexandre Poletti, Francois P Sarasin, Olivier T Rutschmann
AIMS OF THE STUDY: Profound hyponatremia (<125 mmol/l) is frequent in the emergency department. Its incidence appears to increase during hot weather. Our objectives were to investigate seasonal variations in the incidence of profound hyponatraemia and identify its risk factors. METHODS: The incidence of profound hyponatremia among patients admitted to the emergency department of a university hospital was compared between summer and winter periods over two successive years...
January 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28094030/glucocorticoid-induced-leucine-zipper-protein-regulates-sodium-and-potassium-balance-in-the-distal-nephron
#12
Priyanka Rashmi, GianLuca Colussi, Michael Ng, Xinhao Wu, Atif Kidwai, David Pearce
Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Here we provide evidence supporting a role for GILZ in modulating the balance of renal sodium and potassium excretion by regulating the sodium-chloride cotransporter (NCC) activity in the distal nephron. Gilz(-/-) mice have a higher plasma potassium concentration and lower fractional excretion of potassium than wild type mice...
January 13, 2017: Kidney International
https://www.readbyqxmd.com/read/28052988/potassium-sensing-by-renal-distal-tubules-requires-kir4-1
#13
Catherina A Cuevas, Xiao-Tong Su, Ming-Xiao Wang, Andrew S Terker, Dao-Hong Lin, James A McCormick, Chao-Ling Yang, David H Ellison, Wen-Hui Wang
The mammalian distal convoluted tubule (DCT) makes an important contribution to potassium homeostasis by modulating NaCl transport. The thiazide-sensitive Na(+)/Cl(-) cotransporter (NCC) is activated by low potassium intake and by hypokalemia. Coupled with suppression of aldosterone secretion, activation of NCC helps to retain potassium by increasing electroneutral NaCl reabsorption, therefore reducing Na(+)/K(+) exchange. Yet the mechanisms by which DCT cells sense plasma potassium concentration and transmit the information to the apical membrane are not clear...
January 4, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28043731/acetazolamide-and-hydrochlorothiazide-followed-by-furosemide-versus-furosemide-and-hydrochlorothiazide-followed-by-furosemide-for-the-treatment-of-adults-with-nephrotic-edema-a-randomized-trial
#14
Mohammad Amin Fallahzadeh, Banafshe Dormanesh, Mohammad Kazem Fallahzadeh, Jamshid Roozbeh, Mohammad Hossein Fallahzadeh, Mohammad Mahdi Sagheb
BACKGROUND: Nephrotic edema is considered refractory if it does not respond to maximum or near-maximum doses of loop diuretics. This condition can be treated with loop diuretics and thiazides. However, animal studies show that the simultaneous downregulation of pendrin with acetazolamide and inhibition of the sodium-chloride cotransporter with hydrochlorothiazide generates significant diuresis, and furosemide administration following a pendrin inhibitor potentiates furosemide's diuretic effect...
December 30, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28041953/synthetic-approaches-towards-the-multi-target-drug-spironolactone-and-its-potent-analogues-derivatives
#15
REVIEW
Fayaz Ali Larik, Aamer Saeed, Danish Shahzad, Muhammad Faisal, Hesham El-Seedi, Haroon Mehfooz, Pervaiz Ali Channar
Spironolactone is a well-known multi-target drug and is specifically used for the treatment of high blood pressure and heart failure. It is also used for the treatment of edema, cirrhosis of the liver, malignant, pediatric, nephrosis and primary hyperaldosteronism. Spironolactone in association with thiazide diuretics treats hypertension and in association with furosemide treats bronchopulmonary dyspepsia. The therapeutic mechanism of action of spironolactone involves binding to intracellular mineralocorticoids receptors (MRs) in kidney epithelial cells, thereby inhibiting the binding of aldosterone...
December 29, 2016: Steroids
https://www.readbyqxmd.com/read/28040349/-effect-of-drugs-for-osteoporosis-on-cardiovascular-diseases-and-effect-of-cardio-vascular-drugs-on-osteoporosis
#16
Michel Laroche, Yannick Degboe, Hubert Blain, Véronique Breuil, Roland Chapurlat, Bernard Cortet, Bruno Sutter
Osteoporosis and cardiovascular diseases are epidemiologically associated. Calcification phenomena of atherosclerotic plaque involve cytokines and growth factors also involved in bone remodeling. Drugs given for either of these two conditions could act on these mechanisms. Can osteoporosis drugs have an influence on the occurrence of cardiovascular events? Conversely, can the treatment of hypertension alter the course of osteoporosis? It is possible that administration of high doses of calcium (1g/day) in patients who already have important dietary intake can increase the risk of myocardial infarction...
December 28, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/28038989/increased-plasma-rbp4-concentration-in-older-hypertensives-is-related-to-the-decreased-kidney-function-and-the-number-of-antihypertensive-drugs-results-from-the-polsenior-substudy
#17
Marcin Majerczyk, Piotr Choręza, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Habibullah Arabzada, Aleksander Owczarek, Małgorzata Mossakowska, Tomasz Grodzicki, Tomasz Zdrojewski, Andrzej Więcek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
Increased plasma retinol-binding protein 4 (RBP4), a novel adipokine, has been associated in previous studies with obesity, type 2 diabetes, dyslipidemia, hypertension (HT), atherosclerosis, and coronary artery disease. This study aimed to analyze the relationship between HT occurrence and its treatment, and plasma RBP4 concentrations in the older polish population. The study sample consisted of 1728 (890 men and 838 women) PolSenior study participants aged 65 years and older with available plasma samples and NT-proBNP values below 2000 pg/mL...
December 7, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28005702/time-to-the-peak-of-the-aortic-forward-wave-determines-the-impact-of-aortic-backward-wave-and-pulse-pressure-on-left-ventricular-mass
#18
Grace Tade, Gavin R Norton, Hendrik L Booysen, Moekanyi J Sibiya, Imraan Ballim, Pinhas Sareli, Elena Libhaber, Olebogeng H I Majane, Angela J Woodiwiss
AIM: To determine the degree to which an extended time to the peak of the aortic forward wave or early wave reflection time enhance associations between aortic backward wave pressure and hence central aortic pulse pressure (PPc) and left ventricular mass index (LVMI). METHODS: In 701 adult participants from a community sample either receiving no antihypertensive therapy or receiving low-dose thiazide diuretic monotherapy for at least a year (the major therapy employed), we assessed aortic haemodynamics (SphygmoCor software and wave separation analysis; AtCor Medical, West Ryder, New South Wales, Australia) and LVMI (echocardiography)...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28005557/preadmission-diuretic-use-and-mortality-in-patients-hospitalized-with-hyponatremia-a-propensity-score-matched-cohort-study
#19
Louise Holland-Bill, Christian F Christiansen, Sinna P Ulrichsen, Troels Ring, Jens O Lunde Jørgensen, Henrik T Sørensen
BACKGROUND: Hyponatremia is associated with increased mortality and is frequently induced by diuretic use. It is uncertain whether diuretic use is linked to mortality risk in patients with hyponatremia. STUDY QUESTION: To measure the prognostic impact of diuretic use on 30-day mortality among patients hospitalized with hyponatremia. STUDY DESIGN: Using population-based registries, we identified all patients with a serum sodium measurement <135 mmol/L within 24 hours after acute hospital admission in western Denmark from 2006 to 2012 (cumulative population of 2...
December 15, 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28003286/prescription-of-renin-angiotensin-system-blockers-and-risk-of-acute-kidney-injury-a-population-based-cohort-study
#20
Kathryn E Mansfield, Dorothea Nitsch, Liam Smeeth, Krishnan Bhaskaran, Laurie A Tomlinson
OBJECTIVE: To investigate whether there is an association between use of ACE inhibitors (ACEI) and angiotensin receptor blockers (ARB) and risk of acute kidney injury (AKI). STUDY DESIGN: We conducted a new-user cohort study of the rate of AKI among users of common antihypertensives. SETTING: UK primary care practices contributing to the Clinical Practice Research Datalink (CPRD) eligible for linkage to hospital records data from the Hospital Episode Statistics (HES) database between April 1997 and March 2014...
December 21, 2016: BMJ Open
keyword
keyword
86375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"