keyword
MENU ▼
Read by QxMD icon Read
search

No show

keyword
https://www.readbyqxmd.com/read/28532136/correlation-of-preoperative-and-radical-prostatectomy-gleason-score-examining-the-predictors-of-upgrade-and-downgrade-results
#1
Gholamreza Pourmand, Shahram Gooran, Seyed Reza Hossieni, Fateme Guitynavard, Majid Safavi, Amirsina Sharifi, Ehsan Mokhtari
Preoperative Gleason score (GS) obtained from Trans Rectal Ultra Sonography (TRUS) is the most common grading system to evaluate the appropriate treatment for patients with clinically localized prostate cancer. But this method showed upgraded and downgraded results in comparison to Gleason score obtained from radical prostatectomy. The current study aimed to determine clinical or pathological variables to reduce the differences between biopsy and radical prostatectomy Gleason scores.Through retrospective review of 52 patients with radical prostatectomy, this study examined the correlations of preoperative Gleason score with age, prostate volume, PSA level, PSA density, digital rectal exam findings and percentage of positive core needle biopsies across two groups, including patients with preoperative GS≤6 (i...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28532133/neutrophil-lymphocyte-ratio-in-different-stages-of-breast-cancer
#2
Fezzeh Elyasinia, Mohammad Reza Keramati, Farham Ahmadi, Susan Rezaei, Mohammad Ashouri, Reza Parsaei, Maryam Yaghoubi, Fahimeh Elyasinia, Armita Aboutorabi, Ahmad Kaviani
Despite many advances in the treatment of breast cancer, it is still the second most common cause of death in women in the United States. It has been shown that inflammation plays a major role in the treatment of these cancers and inflammatory factors enhance tumor growth, invasion, metastasis, and vascularization. In this study, we would like to analyze peripheral blood neutrophil-lymphocyte ratio (NLR) in breast cancer patients and its correlation with disease staging. This cross-sectional analytic study was conducted in Imam Hospital, affiliated with Tehran University of Medical Sciences; a total of 195 female patients with breast cancer met the inclusion criteria...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28532129/-131-i-traced-plga-lipid-nanoparticles-as-drug-delivery-carriers-for-the-targeted-chemotherapeutic-treatment-of-melanoma
#3
Haiyan Wang, Weizhong Sheng
Herein, folic acid (FA) conjugated Poly(d,l-lactide-co-glycolide) (PLGA)-lipid composites (FA-PL) were developed as nanocarriers for the targeted delivery of insoluble anti-cancer drug paclitaxel (PTX), resulting FA-PLP nanoparticles. Furthermore, (131)I, as a radioactive tracer, was used to label FA-PLP nanoparticles (FA-PLP-(131)I) to evaluate their cell uptake activity, in vivo blood circulation, and biodistribution. The FA-PLP-(131)I nanoparticles had a spherical morphology with great stability, a narrow size distribution (165...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28532126/poly-%C3%AE-glutamic-acid-coated-lipoplexes-loaded-with-doxorubicin-for-enhancing-the-antitumor-activity-against-liver-tumors
#4
Na Qi, Bo Tang, Guang Liu, Xingsi Liang
The study was to develop poly-γ-glutamic acid (γ-PGA)-coated Doxorubicin (Dox) lipoplexes that enhance the antitumor activity against liver tumors. γ-PGA-coated lipoplexes were performed by electrostatistically attracting to the surface of cationic charge liposomes with anionic γ-PGA. With the increasing of γ-PGA concentration, the particle size of γ-PGA-coated Dox lipoplexes slightly increased, the zeta potential from positive shifted to negative, and the entrapment efficiency (EE) were no significant change...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28532095/antitumor-activity-and-safety-evaluation-of-nanaparticle-based-delivery-of-quercetin-through-intravenous-administration-in-mice
#5
Jian Li, Ming Shi, Baoling Ma, Ruixu Niu, Haizhao Zhang, Li Kun
The present study focused on the inhibition effects and the safety evaluation of the quercetin when it was loaded into the nanoliposomes on cervical cancer in vitro and in vivo. Quercetin loaded nanoliposomes (Que-NLs) were first prepared by thin film hydration method and the characterizations of Que-NLs were measured with TEM and dynamic light scattering (DLS) techniques. Then the anti-cervical cancer efficiencies were evaluated by MTT and U14 tumor-bearing mice models in vitro and in vivo respectively. The body changes, organ index, biochemical criterions and histopathological of livers and kidneys in tumor-bearing mice were further assayed to evaluate the safety of Que-NLs...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532092/cytocompatibility-studies-of-titania-doped-calcium-borosilicate-bioactive-glasses-in-vitro
#6
Rajkumar Samudrala, Abdul Azeem P, Vasudevarao Penugurti, Bramanandam Manavathi
The present study aims to elucidate the applications of Titania (TiO2) doped calcium borosilicate glass as a biocompatible material in regenerative orthopedic applications. In this context, we have examined the bioactivity of various concentrations of TiO2 doped glasses with the help of simulated body fluid (SBF). Cytocompatibility, cell proliferation, and protein expression studies revealed the potential candidature of TiO2 doped glasses on osteoblast cell lines (MG-63). We hypothesized that TiO2 doped calcium borosilicate glasses are most cytocompatible material for bone implants...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532090/in-situ-synthesis-of-bilayered-gradient-poly-vinyl-alcohol-hydroxyapatite-composite-hydrogel-by-directional-freezing-thawing-and-electrophoresis-method
#7
Cui Su, Yunlan Su, Zhiyong Li, Muhammad Abdul Haq, Yong Zhou, Dujin Wang
Bilayered poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) composite hydrogels with anisotropic and gradient mechanical properties were prepared by the combination of directional freezing-thawing (DFT) and electrophoresis method. Firstly, PVA hydrogels with aligned channel structure were prepared by the DFT method. Then, HA nanoparticles were in situ synthesized within the PVA hydrogels via electrophoresis. By controlling the time of the electrophoresis process, a bilayered gradient hydrogel containing HA particles in only half of the gel region was obtained...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532069/photothermal-conversion-efficiency-and-cytotoxic-effect-of-gold-nanorods-stabilized-with-chitosan-alginate-and-poly-vinyl-alcohol
#8
M Almada, B H Leal-Martínez, N Hassan, M J Kogan, M G Burboa, A Topete, M A Valdez, J Juárez
Gold nanorods (GNR) use has been proposed in medical applications because of their intrinsic photothermal properties. However, the presence of CTAB molecules adsorbed onto the surface of GNRs results in a highly cytotoxic GNR system. In this work we replace the CTAB molecules with a thiolated chitosan. Once chitosan coated GNRs (Chi-SH-GNR) were attained, a film of alginate (Alg-Chi-SH-GNR) or polyvinyl alcohol (PVA-Chi-SH-GNR) was deposited onto the surface of Chi-GNR by a layer-by-layer process. The photothermal conversion efficiency for the GNR systems was determined irradiating the GNRs suspended in aqua media with a CW 808nm diode laser (CNI, China)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532068/synthetic-peptides-derived-from-salivary-proteins-and-the-control-of-surface-charge-densities-of-dental-surfaces-improve-the-inhibition-of-dental-calculus-formation
#9
Bernd Grohe
Peptides descended from the salivary proteins statherin and histatin were recently identified in saliva and the acquired enamel pellicle (AEP), a proteomic layer coated on enamel. In particular, the statherin phosphopeptide DpSpSEEKFLR (DSS) was found to adsorb to enamel-like hydroxyapatite and inhibit plaque-related crystal formation. To determine the mechanism of these processes, we studied peptide-crystal interactions based on the sequences DSS and RKFHEKHHSHRGYR (RKF). The latter is a basic histatin sequence showing antimicrobial effects...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532067/development-of-biocompatible-and-safe-polyethersulfone-hemodialysis-membrane-incorporated-with-functionalized-multi-walled-carbon-nanotubes
#10
Muhammad Nidzhom Zainol Abidin, Pei Sean Goh, Ahmad Fauzi Ismail, Mohd Hafiz Dzarfan Othman, Hasrinah Hasbullah, Noresah Said, Siti Hamimah Sheikh Abdul Kadir, Fatmawati Kamal, Mohd Sohaimi Abdullah, Be Cheer Ng
A novel approach in the design of a safe, high performance hemodialysis membrane is of great demand. Despite many advantages, the employment of prodigious nanomaterials in hemodialysis membrane is often restricted by their potential threat to health. Hence, this work focusses on designing a biocompatible polyethersulfone (PES) hemodialysis membrane embedded with poly (citric acid)-grafted-multi walled carbon nanotubes (PCA-g-MWCNTs). Two important elements which could assure the safety of the nanocomposite membrane, i...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532066/design-and-characterization-of-a-novel-nickel-free-cobalt-base-alloy-for-intravascular-stents
#11
Qiang Wang, Yibin Ren, M Babar Shahzad, Wei Zhang, Xumeng Pan, Song Zhang, Dan Zhang
Co-Cr-W-Ni alloy (L605) with high tensile strength is used in coronary stents. The thickness of individual strut of the stent is reduced which can decrease the stent restenosis rate. However, about 10% Ni element content in L605 is found to cause allergic reactions and pulmonary embolism, similar to the traditional 316L stainless steel. In this study, a novel nickel-free cobalt-base alloy Co-20Cr-12Fe-18Mn-2Mo-4W-N (wt%) was designed and fabricated in order to efficiently avoid the potential hazards of Ni element...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532061/wound-healing-effect-of-bioactive-ion-released-from-mg-smectite
#12
Yu Sasaki, Gulsan Ara Sathi, Osamu Yamamoto
Bioactive ions like Mg(2+) and Si(4+) have been known as promotion factors of tissue regeneration. In the present work, Mg-smectite, consisting of Mg(2+) and Si(4+) ions, was synthesized by a solution process, and evaluated for the efficiency of the powder on wound healing in rats. White precipitates were obtained by mixing a magnesium chloride hexahydrate solution and a sodium silicate hexahydrate solution at room temperature. The precipitates mixed with a NaOH aqueous solution were subjected to hydrothermal reaction, and finally crystalline Mg-smectite powder was obtained...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532047/porous-chitosan-microspheres-for-application-as-quick-in-vitro-and-in-vivo-hemostat
#13
Jixiang Li, Xiaowei Wu, Yanqing Wu, Zonghao Tang, Xun Sun, Meng Pan, Yufeng Chen, Juanjuan Li, Rongdong Xiao, Zhengchao Wang, Haiqing Liu
Controlling massive hemorrhage is of great importance to lower transfusional medical cost, and to reduce death and mobility rate in battlefield and civilian accidents. We reported the fabrication of porous chitosan microspheres (CSMS) with tunable surface pore size by microemulsion combined with thermally induced phase separation technique, and its application as a quick hemostat. Their hemostatic property was characterized by blood clotting kinetics, adherence interaction between red blood cells/platelets and CSMS, in vitro and in vivo hemostasis by rat tail amputation and liver laceration models, and histological analysis...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532042/ph-responsive-poly-aspartic-acid-hydrogel-coated-magnetite-nanoparticles-for-biomedical-applications
#14
Jaime Vega-Chacón, María Isabel Amaya Arbeláez, Janaina Habib Jorge, Rodrigo Fernando C Marques, Miguel Jafelicci
A novel multifunctional nanosystem formed by magnetite nanoparticles coated with pH-responsive poly(aspartic acid) hydrogel was developed. Magnetite nanoparticles (Fe3O4) have been intensively investigated for biomedical applications due to their magnetic properties and dimensions similar to the biostructures. Poly(aspartic acid) is a water-soluble, biodegradable and biocompatible polymer, which features makes it a potential candidate for biomedical applications. The nanoparticles surface modification was carried out by crosslinking polysuccinimide on the magnetite nanoparticles surface and hydrolyzing the succinimide units in mild alkaline medium to obtain the magnetic poly(aspartic acid) hydrogel...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532029/surfactin-loaded-polyvinyl-alcohol-pva-nanofibers-alters-adhesion-of-listeria-monocytogenes-to-polystyrene
#15
J J Ahire, D D Robertson, A J van Reenen, L M T Dicks
Surfactin-loaded polyvinyl alcohol (PVA) nanofibers were spun using gravity electrospinning. Scanning electron microscopy (SEM) images showed that nanofibers spun with surfactin are free from bead formation and uniform in diameter. The average nanofiber diameters were decreased (273±39nm, 259±39nm and 217±33nm) with increasing levels of surfactin (0.5, 1.0 and 1.5%, w/v) into PVA (10%, w/v). The 10% (w/v) PVA had average fiber diameter of 303±33nm. Atomic force microscopy (AFM) analysis showed that fibers spun with surfactin are not smooth as PVA fibers...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532027/evaluation-of-different-surface-treatments-on-fiber-post-cemented-with-a-self-adhesive-system
#16
Maíra Prado, Juliana N Marques, Gisele Damiana Pereira, Eduardo M da Silva, Renata A Simão
Surface treatment of fiber-reinforced posts can increase adhesion, especially on the post/resin cement interface. The purpose of this in vitro study was to evaluate the effect of different surface treatments on fiber post cemented with a self-adhesive system. Sixty fiberglass epoxy resin posts were cleaned, dried and divided into 6 groups (n=10): Control (no surface treatment), silane (silane coupling agent was applied homogeneously on surface), 24% hydrogen peroxide (H2O2) (immersion during 1min), blasting (blasting with aluminum oxide for 30s), NH3 plasma (plasma treatment for 3min) and HMDSO plasma (plasma treatment for 15min)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532015/effect-of-sintering-temperature-rise-from-870-to-920%C3%A2-c-on-physicomechanical-and-biological-quality-of-nano-hydroxyapatite-an-explorative-multi-phase-experimental-in-vitro-vivo-study
#17
Ahad Khoshzaban, Vahid Rakhshan, Farhood Najafi, Leila Aghajanpour, Seyed Jafar Hashemian, Saeed Heidari Keshel, Ikuya Watanabe, Alireza Valanezhad, Tahereh Sadat Jafarzadeh Kashi
Hydroxyapatite (HA) is a proper scaffold for bone repair, however, it is not of excellent mechanical properties. Most previous studies on the effect of temperature increases were in vitro and had assessed merely improvements of HA's physicomechanical quality. This in vitro/vivo study investigated the effect of temperature increases from 870 to 920°C on physicomechanical and biological quality of Nano-HA. Forty experimentally produced HA disks sintered at 870 to 920°C were prepared (n=20×2). Disks were subjected to Vickers microindentation test (1 disk from each group divided into 4 quarters), Fourier transform infrared spectroscopy (1 disk), X-ray diffraction (XRD) [1 disk together with non-sintered HA], field emission scanning electron microscopy (FSEM, 1 disk from each group together with non-sintered HA), cell seeding and SEM assessment (2 disks), MTT assay over 4 different time periods (16 quadrants of 4 disks from each group), 6 one-thirds of 2 disks from each group for immunocytochemical (ICC) assay, and 8 disks from each group [as well as non-sintered HA] for the animal study (implantation in 4 sockets in 8 rabbits [32 specimens], histomorphometry, and computerized tomography) over two time periods...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531969/biogeographical-factors-affecting-the-distribution-of-stream-salamanders-on-the-cumberland-plateau-usa
#18
P R Gould, K K Cecala, S S Drukker, B A McKenzie, C Van de Ven
Geophysical and climate conditions play an important role in the distribution of organisms at both fine and broad scales. Headwater streams integrate changes at broad geographical scales and serve as important regions of nutrient processing and support high biodiversity. Stream salamanders are important members of headwater aquatic communities as both predators and prey. Combined with their biphasic life histories and physiological requirements, stream amphibians may serve as indicators for headwater stream conditions...
May 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531965/does-arbuscular-mycorrhizal-fungus-affect-cadmium-uptake-and-chemical-forms-in-rice-at-different-growth-stages
#19
Na Luo, Xing Li, Ao Yu Chen, Li Jun Zhang, Hai Ming Zhao, Lei Xiang, Quan Ying Cai, Ce Hui Mo, Ming Hung Wong, Hui Li
Effects of the arbuscular mycorrhizal fungus (AMF) - Rhizophagus intraradices (a mix of root pieces, mycelium pieces and spores) on the temporal variation of Cd uptake and chemical forms in rice at four growth periods (tillering, jointing, flowering, and ripening stages) were investigated in soil added with 0, 2 and 10mgCdkg(-1). Results showed that the interactions amongst rice growth stages, soil Cd concentrations and mycorrhizal inoculation had significant effects (P˂0.001) on root biomass, straw and root Cd concentrations, and straw Cd chemical forms in rice...
May 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531940/contusional-cerebellar-hemorrhage-related-to-placement-in-the-protrusion-position-after-atlantoaxial-fusion
#20
Yoshinari Miyaoka, Mikinobu Takeuchi, Norimitsu Wakao, Masahiro Aoyama, Kazuhiro Hongo, Masakazu Takayasu
BACKGROUND: Various complications after C1 lateral mass and C2 pedicle screw fusion surgery (C1LM-C2PSFS) have been reported. However, to our knowledge, this is the first report of contusional cerebellar hemorrhage caused by placement in the protrusion (chin-out) position after C1LM-2PSFS. CASE DESCRIPTION: An 81-year-old woman complaining of gait disturbance and clumsiness of both hands was diagnosed with cervical myelopathy with atlantoaxial subluxation. After we performed C1LM-C2PSFS, her neurologic deficits gradually improved, and there was no radiologic evidence of construct failure...
May 2017: World Neurosurgery
keyword
keyword
86373
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"