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innovation of light

Pavani Rangachari
In 1999, the Institute of Medicine reported that 98,000 people die each year due to medical errors. In the following years, the focus on hospital quality was intensified nationally, with policymakers providing evidence-based practice guidelines for improving health care quality. However, these innovations (evidence-based guidelines) that were being produced at policy levels were not translating to clinical practice at the hospital organizational level easily, and stark variations continued to persist, in the quality of health care...
2018: Innov Entrep Health
Shiguang Wang, Bingtian Ma, Qiang Gao, Guojing Jiang, Lei Zhou, Bin Tu, Peng Qin, Xueqin Tan, Peixiong Liu, Yunhai Kang, Yuping Wang, Weilan Chen, Chengzhi Liang, Shigui Li
Shuhui498 (R498) is an elite parent of heavy panicle hybrid rice by pyramiding the rare gn1a and null gs3 alleles. This finding reveals the genetic basis and great potential application in future breeding of R498. The heavy panicle trait, defined as 5 g or more of grain weight per panicle, is one of the target traits in super-high-yield rice breeding programs. The use of heavy panicle-type hybrid rice has been shown to be a successful strategy for super-high-yield breeding programs, particularly under the environmental conditions of high humidity and deficient solar radiation in southwestern China...
March 15, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Mónica Herrero-Huerta, Roderik Lindenbergh, Wolfgang Gard
Plant leaf movement is induced by some combination of different external and internal stimuli. Detailed geometric characterization of such movement is expected to improve understanding of these mechanisms. A metric high-quality, non-invasive and innovative sensor system to analyze plant movement is Terrestrial LiDAR (TLiDAR). This technique has an active sensor and is, therefore, independent of light conditions, able to obtain accurate high spatial and temporal resolution point clouds. In this study, a movement parameterization approach of leaf plants based on TLiDAR is introduced...
2018: Frontiers in Plant Science
Noelia Tena, Ramon Aparicio, Diego Luis Garcia-Gonzalez
Developing new approaches to evaluate the stability of edible oils under moderate conditions is highly demanded today to avoid accelerated experiments that are not well correlated with actual shelf life. In particular, low intensity of visible light (photooxidation) needs to be integrated in stability studies, together with mild temperature. Thus, in this work a strategy based on 'mesh cell'-FTIR to monitor chemical changes in lipid matrices as consequence of a combination of light and mild heating was applied...
March 10, 2018: Journal of Agricultural and Food Chemistry
Antonio Di Martino, Marina E Trusova, Pavel S Postnikov, Vladimir Sedlarik
An innovative microcarrier based on a carboxy-enriched and branched polylactic acid derivative was developed to enhance the in vitro phototoxicity of the photosensitizer and prodrug 5-aminolevulinic. Microparticles, prepared by double emulsion technique and loaded with the prodrug were carefully characterized and the effect of the polymer structure on the chemical, physical and biological properties of the final product was evaluated. Results showed that microparticles have a spherical shape and ability to allocate up to 30 μg of the photosensitizer per mg of carrier despite their difference in solubility...
March 3, 2018: Journal of Photochemistry and Photobiology. B, Biology
Paolo Bellavista, Federico Caselli, Antonio Corradi, Luca Foschini
The relevance of effective and efficient solutions for vehicle traffic surveillance is widely recognized in order to enable advanced strategies for traffic management, e.g., based on dynamically adaptive and decentralized traffic light management. However, most related solutions in the literature, based on the powerful enabler of cooperative vehicular communications, assume the complete penetration rate of connectivity/communication technologies (and willingness to participate in the collaborative surveillance service) over the targeted vehicle population, thus making them not applicable nowadays...
March 9, 2018: Sensors
A H Reid, X Shen, P Maldonado, T Chase, E Jal, P W Granitzka, K Carva, R K Li, J Li, L Wu, T Vecchione, T Liu, Z Chen, D J Higley, N Hartmann, R Coffee, J Wu, G L Dakowski, W F Schlotter, H Ohldag, Y K Takahashi, V Mehta, O Hellwig, A Fry, Y Zhu, J Cao, E E Fullerton, J Stöhr, P M Oppeneer, X J Wang, H A Dürr
"The technical support from SLAC Accelerator Directorate, Technology Innovation Directorate, LCLS laser division and Test Facility Division is gratefully acknowledged. We thank S.P. Weathersby, R.K. Jobe, D. McCormick, A. Mitra, S. Carron and J. Corbett for their invaluable help and technical assistance. Research at SLAC was supported through the SIMES Institute which like the LCLS and SSRL user facilities is funded by the Office of Basic Energy Sciences of the U.S. Department of Energy under Contract No...
March 7, 2018: Nature Communications
Prisca A Oria, Michiel Wijnands, Jane Alaii, Cees Leeuwis
BACKGROUND: In 2012, a donor-supported proof of principle study was launched to eliminate malaria from Rusinga Island, western Kenya, using solar-powered mosquito trapping systems (SMoTS). SMoTS, which also provided power for room lighting and charging mobile telephones, were installed in houses. In view of the involvement of individual and collective benefits, as well as individual and collective maintenance solutions, this study qualitatively examined preferences of some project stakeholders towards SMoTS sustainability components to see if and how they related to social dilemma factors...
March 6, 2018: BMC Public Health
Florian Douam, Floriane Fusil, Margot Enguehard, Linda Dib, Francesca Nadalin, Loïc Schwaller, Gabriela Hrebikova, Jimmy Mancip, Laurent Mailly, Roland Montserret, Qiang Ding, Carine Maisse, Emilie Carlot, Ke Xu, Els Verhoeyen, Thomas F Baumert, Alexander Ploss, Alessandra Carbone, François-Loïc Cosset, Dimitri Lavillette
Amino-acid coevolution can be referred to mutational compensatory patterns preserving the function of a protein. Viral envelope glycoproteins, which mediate entry of enveloped viruses into their host cells, are shaped by coevolution signals that confer to viruses the plasticity to evade neutralizing antibodies without altering viral entry mechanisms. The functions and structures of the two envelope glycoproteins of the Hepatitis C Virus (HCV), E1 and E2, are poorly described. Especially, how these two proteins mediate the HCV fusion process between the viral and the cell membrane remains elusive...
March 5, 2018: PLoS Pathogens
Halina Binde Doria, Marianna Boia Ferreira, Silvia Daniele Rodrigues, Sze Mei Lo, Cinthia Eloise Domingues, Lia Sumie Nakao, Sandro Xavier de Campos, Ciro Alberto de Oliveira Ribeiro, Marco Antonio Ferreira Randi
The circadian clock is a key cellular timing system that coordinates physiology and behavior. Light is a key regulator of the clock mechanism via its activation of Per and Cry clock gene expression. Evidence points to a key role of reactive oxygen species (ROS) in resetting this process. In this context, the aim of the present study was to explore copper as a ROS generator, using an innovative approach investigating its effects on circadian timing. Liver and brain from Danio rerio specimens exposed to 0, 5, 25 and 45 μg/L copper concentrations were obtained...
February 27, 2018: Ecotoxicology and Environmental Safety
Andrea Ancona, Bianca Dumontel, Nadia Garino, Benjamin Demarco, Dimitra Chatzitheodoridou, Walter Fazzini, Hanna Engelke, Valentina Cauda
In the present paper, we use zinc oxide nanoparticles under the excitation of ultraviolet (UV) light for the generation of Reactive Oxygen Species (ROS), with the aim of further using these species for fighting cancer cells in vitro. Owing to the difficulties in obtaining highly dispersed nanoparticles (NPs) in biological media, we propose their coating with a double-lipidic layer and we evaluate their colloidal stability in comparison to the pristine zinc oxide NPs. Then, using Electron Paramagnetic Resonance (EPR) coupled with the spin-trapping technique, we demonstrate and characterize the ability of bare and lipid-coated ZnO NPs to generate ROS in water only when remotely actuated via UV light irradiation...
March 2, 2018: Nanomaterials
Sohrab Asefi, Massoud Seifi, Ghazal Hatami Fard, Ali Lotfi
Background: Curcumin is the most active compound in turmeric. It can suppress the nuclear factor kappa-light-chain-enhancer of activated B cells pathway and prevent the osteoclastogenesis procedure. This study aimed to be the first to evaluate the effect of curcumin on the rate of orthodontic tooth movement (OTM). Materials and Methods: Forty rats were used as follows in each group: (1) negative control: Did not receive any appliance or injection; (2) positive control: received 0...
January 2018: Dental Research Journal
Andrea Pezzuolo, Marcella Guarino, Luigi Sartori, Francesco Marinello
Frequent checks on livestock's body growth can help reducing problems related to cow infertility or other welfare implications, and recognizing health's anomalies. In the last ten years, optical methods have been proposed to extract information on various parameters while avoiding direct contact with animals' body, generally causes stress. This research aims to evaluate a new monitoring system, which is suitable to frequently check calves and cow's growth through a three-dimensional analysis of their bodies' portions...
February 24, 2018: Sensors
B Merk, D Litskevich, R Gregg, A R Mount
The PUREX technology based on aqueous processes is currently the leading reprocessing technology in nuclear energy systems. It seems to be the most developed and established process for light water reactor fuel and the use of solid fuel. However, demand driven development of the nuclear system opens the way to liquid fuelled reactors, and disruptive technology development through the application of an integrated fuel cycle with a direct link to reactor operation. The possibilities of this new concept for innovative reprocessing technology development are analysed, the boundary conditions are discussed, and the economic as well as the neutron physical optimization parameters of the process are elucidated...
2018: PloS One
Gary Alex
Among the goals of pulp capping are to manage bacteria, arrest caries progression, stimulate pulp cells to form new dentin, and produce a durable seal that protects the pulp complex. This article will provide a general discussion of direct and indirect pulp capping procedures, offering practitioners a pragmatic and science-based clinical protocol for treatment of vital pulp exposures. A clinical case will be presented in which a novel light-cured resin-modified mineral trioxide aggregate hybrid material was used to manage a mechanical vital pulp exposure that occurred during deep caries excavation...
March 2018: Compendium of Continuing Education in Dentistry
Kimberley F Prior, Daan R van der Veen, Aidan J O'Donnell, Katherine Cumnock, David Schneider, Arnab Pain, Amit Subudhi, Abhinay Ramaprasad, Samuel S C Rund, Nicholas J Savill, Sarah E Reece
Circadian rhythms enable organisms to synchronise the processes underpinning survival and reproduction to anticipate daily changes in the external environment. Recent work shows that daily (circadian) rhythms also enable parasites to maximise fitness in the context of ecological interactions with their hosts. Because parasite rhythms matter for their fitness, understanding how they are regulated could lead to innovative ways to reduce the severity and spread of diseases. Here, we examine how host circadian rhythms influence rhythms in the asexual replication of malaria parasites...
February 26, 2018: PLoS Pathogens
Mingjun Xuan, Jingxin Shao, Jie Zhao, Qi Li, Luru Dai, Junbai Li
Targeted drug delivery represents an emerging technological strategy, and enables nanoparticle systems are responsible for tumor therapy. This work describes a magnetic mesoporous silica nanoparticle (MMSN) cloaked with red blood cell membrane (RBC), which integrates with long circulation, photosensitizer delivery, and magnetic targeting feature for cancer therapy. In vivo experiments demonstrate that RBC@MMSNs can avoid the immune clearance, and achieve magnetic field (MF) induced high-accumulation in tumor...
February 26, 2018: Angewandte Chemie
Yao Wu, Xin Yan, Xia Zhang, Xiaomin Ren
An innovative solar cell based on a nanowire/quantum dot hybrid nanostructure array is designed and analyzed. By growing multilayer InAs quantum dots on the sidewalls of GaAs nanowires, not only the absorption spectrum of GaAs nanowires is extended by quantum dots but also the light absorption of quantum dots is dramatically enhanced due to the light-trapping effect of the nanowire array. By incorporating five layers of InAs quantum dots into a 500-nm high-GaAs nanowire array, the power conversion efficiency enhancement induced by the quantum dots is six times higher than the power conversion efficiency enhancement in thin-film solar cells which contain the same amount of quantum dots, indicating that the nanowire array structure can benefit the photovoltaic performance of quantum dot solar cells...
February 23, 2018: Nanoscale Research Letters
E A Maden, C Altun, B Ozmen, F Basak
Aim: This in vivo study was designed to compare the antimicrobial effect of toothpastes containing fluoride, xylitol, or xylitol-probiotic on Streptococcus mutans and Lactobacillus in 13-15-year-old children. Materials and Methods: The study consisted of 60 pediatric patients who were randomly divided into three groups of 20 each. Group 1 recieved fluoride toothpaste (Colgate Max Fresh), group 2 used xylitol toothpaste (Xyliwhite), and group 3 used xylitol-probiotic toothpaste (PerioBiotic)...
February 2018: Nigerian Journal of Clinical Practice
Jacob Krüger Jensen, Marta Busse-Wicher, Christian Peter Poulsen, Jonatan Ulrik Fangel, Peter James Smith, Jeong-Yeh Yang, Maria-Jesus Peña, Malene Hessellund Dinesen, Helle Juel Martens, Michael Melkonian, Gane Ka-Shu Wong, Kelley W Moremen, Curtis Gene Wilkerson, Henrik Vibe Scheller, Paul Dupree, Peter Ulvskov, Breeanna Rae Urbanowicz, Jesper Harholt
Insights into the evolution of plant cell walls have important implications for comprehending these diverse and abundant biological structures. In order to understand the evolving structure-function relationships of the plant cell wall, it is imperative to trace the origin of its different components. The present study is focused on plant 1,4-β-xylan, tracing its evolutionary origin by genome and transcriptome mining followed by phylogenetic analysis, utilizing a large selection of plants and algae. It substantiates the findings by heterologous expression and biochemical characterization of a charophyte alga xylan synthase...
February 20, 2018: New Phytologist
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