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https://www.readbyqxmd.com/read/27917861/submillimetre-network-formation-by-light-induced-hybridization-of-zeptomole-level-dna
#1
Takuya Iida, Yushi Nishimura, Mamoru Tamura, Keisuke Nishida, Syoji Ito, Shiho Tokonami
Macroscopic unique self-assembled structures are produced via double-stranded DNA formation (hybridization) as a specific binding essential in biological systems. However, a large amount of complementary DNA molecules are usually required to form an optically observable structure via natural hybridization, and the detection of small amounts of DNA less than femtomole requires complex and time-consuming procedures. Here, we demonstrate the laser-induced acceleration of hybridization between zeptomole-level DNA and DNA-modified nanoparticles (NPs), resulting in the assembly of a submillimetre network-like structure at the desired position with a dramatic spectral modulation within several minutes...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27911101/in-vivo-and-ex-vivo-evaluation-of-inflammation-and-apoptosis-induced-after-smile-procedures-for-different-refractive-error-range
#2
Leonardo Mastropasqua, Roberta Calienno, Claudia Curcio, Rodolfo Mastropasqua, Mario Nubile, Niccolò Salgari, Manuela Lanzini
PURPOSE: To detect corneal inflammation and apoptosis induced after small incision lenticule extraction (SMILE) at different refractive corrections for moderate to high values of myopia. METHODS: Fifty patients (50 eyes) suffering from medium to high myopia (spherical equivalent refraction from -3.75 to -10.00 diopters (D) with refractive astigmatism under -0.75 D) underwent SMILE in order to correct myopic error. In vivo evaluation was done by corneal confocal microscopy (IVCM) and ex vivo by immunohistochemistry...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27908788/time-to-wake-up-studying-neurovascular-coupling-and-brain-wide-circuit-function-in-the-un-anesthetized-animal
#3
REVIEW
Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T Winder, Zhifeng Liang, Lilith Antinori, Patrick J Drew, Nanyin Zhang
Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-based and resting-state brain dynamics in humans by inferring neural activity from blood-oxygenation-level dependent (BOLD) signal changes. An accurate interpretation of the hemodynamic changes that underlie fMRI signals depends on the understanding of the quantitative relationship between changes in neural activity and changes in cerebral blood flow, oxygenation and volume. While there has been extensive study of neurovascular coupling in anesthetized animal models, anesthesia causes large disruptions of brain metabolism, neural responsiveness and cardiovascular function...
November 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27900742/-precision-nursing-individual-based-knowledge-translation
#4
Li-Chi Chiang, Mei-Ling Yeh, Sui-Lung Su
U.S. President Obama announced a new era of precision medicine in the Precision Medicine Initiative (PMI). This initiative aims to accelerate the progress of personalized medicine in light of individual requirements for prevention and treatment in order to improve the state of individual and public health. The recent and dramatic development of large-scale biologic databases (such as the human genome sequence), powerful methods for characterizing patients (such as genomics, microbiome, diverse biomarkers, and even pharmacogenomics), and computational tools for analyzing big data are maximizing the potential benefits of precision medicine...
December 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27893392/waterloo-exploration-database-new-challenges-for-image-quality-assessment-models
#5
Kede Ma, Zhengfang Duanmu, Qingbo Wu, Zhou Wang, Hongwei Yong, Hongliang Li, Lei Zhang
The great content diversity of real-world digital images poses a grand challenge to image quality assessment (IQA) models, which are traditionally designed and validated on a handful of commonly used IQA databases with very limited content variation. To test the generalization capability and to facilitate the wide usage of IQA techniques in realworld applications, we establish a large-scale database named the Waterloo Exploration Database, which in its current state contains 4; 744 pristine natural images and 94; 880 distorted images created from them...
November 22, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27885589/organic-cocrystals-new-strategy-for-molecular-collaborative-innovation
#6
REVIEW
Yu Wang, Weigang Zhu, Huanli Dong, Xiaotao Zhang, Rongjin Li, Wenping Hu
Organic cocrystals that are composed of two or more components usually exhibit novel, unpredictable, and even unique properties rather than a simple combination of the properties of their components, such as white-light emission, ambipolar charge transport, nonlinear optics, and ferroelectricity. Since cocrystal engineering represents a novel strategy for synthesizing multifunctional materials, which opens the door for molecular collaborative innovation, it has aroused much attention in recent years. However, as it is also a relatively new research field, it is only in its early stages of development...
December 2016: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/27884325/violet-405-nm-light-a-novel-therapeutic-agent-against-common-pathogenic-bacteria
#7
Mitchell D Barneck, Nathaniel L R Rhodes, Martin de la Presa, James P Allen, Ahrash E Poursaid, Maziar M Nourian, Matthew A Firpo, John T Langell
BACKGROUND: The increasing incidence of healthcare-associated infections (HAIs) and multidrug-resistant organisms demonstrate the need for innovative technological solutions. Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli, and Pseudomonas aeruginosa in particular are common pathogens responsible for a large percentage of indwelling medical device-associated clinical infections. The bactericidal effects of visible light sterilization (VLS) using 405-nm is one potential therapeutic under investigation...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884156/targeted-myocardial-gene-expression-in-failing-hearts-by-rna-sequencing
#8
Kajari Dhar, Alexandra M Moulton, Eric Rome, Fang Qiu, Jeff Kittrell, Eugenia Raichlin, Ronald Zolty, John Y Um, Michael J Moulton, Hesham Basma, Daniel R Anderson, James D Eudy, Brian D Lowes
BACKGROUND: Myocardial recovery with left ventricular assist device (LVAD) therapy is highly variable and difficult to predict. Next generation ribonucleic acid (RNA) sequencing is an innovative, rapid, and quantitative approach to gene expression profiling in small amounts of tissue. Our primary goal was to identify baseline transcriptional profiles in non-ischemic cardiomyopathies that predict myocardial recovery in response to LVAD therapy. We also sought to verify transcriptional differences between failing and non-failing human hearts...
November 25, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27880711/fine-tuning-motile-cilia-and-flagella-evolution-of-the-dynein-motor-proteins-from-plants-to-humans-at-high-resolution
#9
Martin Kollmar
The flagellum is a key innovation linked to eukaryogenesis. It provides motility by regulated cycles of bending and bend propagation, which are thought to be controlled by a complex arrangement of seven distinct dyneins in repeated patterns of outer- (OAD) and inner-arm dynein (IAD) complexes. Electron tomography showed high similarity of this axonemal repeat pattern across ciliates, algae, and animals, but the diversity of dynein sequences across the eukaryotes has not yet comprehensively been resolved and correlated with structural data...
December 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/27877247/beyond-the-barriers-of-light-penetration-strategies-perspectives-and-possibilities-for-photodynamic-therapy
#10
REVIEW
Srivalleesha Mallidi, Sriram Anbil, Anne-Laure Bulin, Girgis Obaid, Megumi Ichikawa, Tayyaba Hasan
Photodynamic therapy (PDT) is a photochemistry based treatment modality that involves the generation of cytotoxic species through the interactions of a photosensitizer molecule with light irradiation of an appropriate wavelength. PDT is an approved therapeutic modality for several cancers globally and in several cases has proved to be effective where traditional treatments have failed. The key parameters that determine PDT efficacy are 1. the photosensitizer (nature of the molecules, selectivity, and macroscopic and microscopic localization etc...
2016: Theranostics
https://www.readbyqxmd.com/read/27876807/assessment-of-human-energy-exchange-historical-overview
#11
REVIEW
S B Heymsfield, B Bourgeois, D M Thomas
Energy exchange is fundamental to life and is a cornerstone in the study of human physiology, metabolism and nutrition. A global effort is underway to further our understanding of human energy exchange and its components as a means of establishing the mechanistic underpinnings of the evolving obesity and chronic disease epidemics. The current report establishes a conceptual historical framework for examining the evolution of energy exchange concepts and measurement methods. We review developments taking place over more than 2000 years during which humans endeavored to establish the source of body heat, the 'fire of life'...
November 23, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27873398/from-the-coliseum-to-the-convention-centre-a-reflection-on-the-current-state-of-medical-education-conferences-and-conference-goers
#12
Rebecca D Blanchard, Deborah L Engle, Lisa D Howley, Shari A Whicker, Alisa Nagler
The advancement of knowledge and development of policy in the field of medical education require critical academic discourse among the most intelligent medical educators; and critical academic discourse requires coffee. In this essay, we reflect on the state of professional development conferences in the field of medical education and the rituals that surround their success. Having begun in ancient Greece, symposia were ripe with debauchery. Today, sedated by the light brown walls of hotel conference centres, symposia are more serious endeavours, engaging men and women in the sometimes turbulent waters of epistemological debate...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27872547/measuring-dental-students-preference-a-comparison-of-light-microscopy-and-virtual-microscopy-as-teaching-tools-in-oral-histology-and-pathology
#13
Ohoud Alotaibi, Dalal ALQahtani
OBJECTIVES: Light microscopy used to be the traditional modality of teaching histology and pathology disciplines. Recent advances and innovations in the information technology field have revolutionized the use of hard- and software in medical education. An example of such an innovation is the so-called virtual microscopy. Many schools have started to adopt virtual microscopy as a new method aimed at enhancing student learning. Nonetheless, few reports have described the experiences of introducing virtual microscopy in dental education...
October 2016: Saudi Dental Journal
https://www.readbyqxmd.com/read/27868441/-evaluation-of-free-radical-quantity-in-the-anterior-chamber-following-femtosecond-laser-assisted-capsulotomy
#14
Gábor Tóth, Gábor László Sándor, Dénes Kleiner, Nóra Szentmáry, Huba J Kiss, Anna Blázovics, Zoltán Zsolt Nagy
INTRODUCTION: Femtosecond laser is a revolutionary, innovative treatment method used in cataract surgery. AIM: To evaluate free radical quantity in the anterior chamber of the eye, during femtosecond laser assisted capsulotomy, in a porcine eye model. METHOD: Seventy fresh porcine eyes were collected within 2 hours post mortem, were transported at 4 ºC and treated within 7 hours. Thirty-five eyes were used as control and 35 as femtosecond laser assisted capsulotomy group...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27862355/recent-progress-on-stretchable-electronic-devices-with-intrinsically-stretchable-components
#15
Tran Quang Trung, Nae-Eung Lee
Stretchable electronic devices with intrinsically stretchable components have significant inherent advantages, including simple fabrication processes, a high integrity of the stacked layers, and low cost in comparison with stretchable electronic devices based on non-stretchable components. The research in this field has focused on developing new intrinsically stretchable components for conductors, semiconductors, and insulators. New methodologies and fabrication processes have been developed to fabricate stretchable devices with intrinsically stretchable components...
November 14, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27860356/micro-endoscopy-of-the-human-vas-deferens-a-feasibility-study-of-a-novel-device-in-several-ex-vivo-models
#16
M Trottmann, R Sroka, C Braun, B Liedl, H Schaaf, M Graw, A J Becker, C G Stief, W Y Khoder
The aim of this study was to show limitation as well as potential of micro-endoscopy techniques as an innovative diagnostic and therapeutic approach in andrology. Two kinds of custom-made micro-endoscopes (ME) were tested in ex vivo vas deferens specimen and in post-mortem whole body. The semi-rigid ME included a micro-optic (0.9 mm outer diameter [OD], 10.000 pixels, 120° vision angle [VE], 3-20 mm field depth [FD]) and an integrated fibre-optic light source. The flexible ME was composed of a micro-optic (OD = 0...
November 17, 2016: Andrology
https://www.readbyqxmd.com/read/27858217/alternative-animal-and-non-animal-models-for-drug-discovery-and-development-bonus-or-burden
#17
Irlan Almeida Freires, Janaina de Cássia Orlandi Sardi, Ricardo Dias de Castro, Pedro Luiz Rosalen
Mammalian models have served as a basis for R&D over the past decades. Nevertheless, these models are expensive, laborious, may yield results that cannot always be translated into the human in vivo situation and, more recently, have reverberated great social and ethical dilemmas. Hence, the prospect of changes in the global scientific scenario and the Three Rs principle (Reduction, Replacement and Refinement) have encouraged the development of alternative methods to the use of mammals. Despite the efforts, suitable alternative tests are not available in all areas of biomedical research, as regulatory acceptance requires time, prior validation and robust financial and scientific investment...
November 17, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27858115/-the-new-esc-guidelines-for-acute-and-chronic-heart-failure-2016
#18
C U Oeing, C Tschöpe, B Pieske
The new guidelines for the diagnosis and treatment of acute and chronic heart failure (HF) were presented in May 2016 during the congress of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in Florence. An important amendment affects the classification of HF which now differentiates between HF with preserved ejection fraction (HFpEF) and left ventricular EF (LVEF) > 50%, HF with reduced ejection fraction (HFrEF, LVEF < 40%) and the new entity HF with mid-range ejection fraction (HFmrEF, LVEF 40-49%)...
December 2016: Herz
https://www.readbyqxmd.com/read/27855347/constructing-embodied-identity-in-a-new-ageing-population-a-qualitative-study-of-the-pioneer-cohort-of-childhood-liver-transplant-recipients-in-the-uk
#19
Karen Lowton, Chris Hiley, Paul Higgs
Medical innovations have created a future of survivorship for many groups of people with a variety of conditions that were previously untreatable or untreated. This has led not only to an expansion of medical activity in a whole variety of new areas but also to the emergence of new groups of individuals defined or defining themselves through their experiences, diagnosis and treatment. Through analysis of in-depth interviews with 27 of the now-adult survivors of the pioneer cohort of children receiving liver transplants in Britain in the early 1980s and 1990s, this paper presents how this group not only illustrate the capacities of modern medicine and healthcare to transform the survival prospects of a more diversified population, but also create new narratives of embodied identity...
November 11, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27854099/minimally-invasive-surgery-for-early-stage-lung-cancer-from-innovation-to-standard-of-care
#20
REVIEW
Abby White, Scott J Swanson
The era of minimally invasive surgery for lung cancer follows decades of research; the collection and interpretation of countless qualitative and quantitative data points; and tireless efforts by a few pioneering thoracic surgeons who believed they could deliver a safe and oncologically sound operation with less tissue trauma, an improved physiologic profile, and fewer complications than traditional open surgery. This review highlights those efforts and the role of minimally invasive surgery for early-stage lung cancer in light of evolving technology, the emerging understanding of the biology of early-stage lung cancer, and lung cancer screening...
November 15, 2016: Oncology (Williston Park, NY)
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