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https://www.readbyqxmd.com/read/28212154/optical-coherence-tomography-and-confocal-laser-endomicroscopy-in-pulmonary-diseases
#1
Lizzy Wijmans, Julia N S d'Hooghe, Peter I Bonta, Jouke T Annema
PURPOSE OF REVIEW: Current imaging techniques (X-ray, computed tomography scan, ultrasound) have limitations in the identification and quantification of pulmonary diseases, in particular, on highly detailed level. The purpose of this review is to provide an overview of the current knowledge of innovative light- and laser-based imaging techniques that might fill this gap. RECENT FINDINGS: Optical coherence tomography (OCT) and confocal laser endomicroscopy (CLE) are high-resolution imaging techniques, which, combined with bronchoscopy, provide 'near histology' detailed imaging of the airway wall, lung parenchyma, mediastinal lymph nodes, and pulmonary vasculature...
February 16, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28203203/health-promotion-development-in-the-spa-treatment-perspectives-for-the-european-countries-learned-from-poland-s-experiences
#2
Joanna Woźniak-Holecka, Piotr Romaniuk, Tomasz Holecki, Aldona Frączkiewicz-Wronka, Sylwia Jaruga
The main aim of the paper is to outline the perspective for future developments of the spa treatment in light of demographic transitions characterized by the increasing number of seniors, as well as changing expectations and health needs of younger population. We made a systematic review of literature referring to the experience of Poland, and similar experiences of other countries in Central Europe. Based on the existing knowledge we conclude that spa treatment should become one of the preferred directions of development of health systems in European countries...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28195238/the-changing-landscape-of-clinical-trial-and-approval-processes-in-china
#3
REVIEW
Qing Zhou, Xiao-Yuan Chen, Zhi-Min Yang, Yi-Long Wu
In the past decade, the standards of clinical trials in China have moved closer to international standards, thus encouraging the development of innovative drugs. However, a large backlog of pending applications for both drug approval and clinical trial registration has arisen owing to the complexity of the approval process, the volume of applications and a lack of staff available to process these applications, among other reasons. To improve the drug approval process, a 'four-colour-light' strategy was introduced...
February 14, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28193072/semiautomated-support-photoelectrochemical-immunosensing-platform-for-portable-and-high-throughput-immunoassay-based-on-au-nanocrystal-decorated-specific-crystal-facets-bivo4-photoanode
#4
Jian Shu, Zhenli Qiu, Zhenzhen Lin, Guoneng Cai, Huanghao Yang, Dianping Tang
Photoelectrochemical (PEC) measurement has been developed rapidly for bioanalysis in recent years. However, the actual application for most existed PEC bioanalytical systems is still a challenge because the perfect solutions for sensing surface design, high-throughput detection, and portability are lacked. To successfully overcome these limitations and realize accurate, continuous screening and assessing on prognostic indicator of early stage cancer on the spot, an innovative and portable semiautomated support power-free photoelectrochemical (SP-PEC) immunosensing platform consisted with a miniature semiautomatic injection system and digital multimeter (DMM) readout is designed (prostate specific antigen, PSA, was used as the proof-of-concept analyte)...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28187183/laboratory-strains-of-aedes-aegypti-are-competent-to-brazilian-zika-virus
#5
André Luis Costa-da-Silva, Rafaella Sayuri Ioshino, Helena Rocha Corrêa de Araújo, Bianca Burini Kojin, Paolo Marinho de Andrade Zanotto, Danielle Bruna Leal Oliveira, Stella Rezende Melo, Edison Luiz Durigon, Margareth Lara Capurro
The Zika virus outbreaks are unprecedented human threat in relation to congenital malformations and neurological/autoimmune complications. Since this virus has high potential to spread in regions presenting the vectors, improvement in mosquito control is a top priority. Thus, Aedes aegypti laboratory strains will be fundamental to support studies in different research fields implicated on Zika-mosquito interactions which are the basis for the development of innovative control methods. In this sense, our aim was to determine the main infection aspects of a Brazilian Zika strain in reference Aedes aegypti laboratory mosquitoes...
2017: PloS One
https://www.readbyqxmd.com/read/28185958/characterisation-of-aggregates-of-cyclodextrin-drug-complexes-using-taylor-dispersion-analysis
#6
Hadar Zaman, Andrew G Bright, Kevin Adams, David M Goodall, Robert T Forbes
There is a need to understand the nature of aggregation of cyclodextrins (CDs) with guest molecules in increasingly complex formulation systems. To this end an innovative application of Taylor dispersion analysis (TDA) and comparison with dynamic light scattering (DLS) have been carried out to probe the nature of ICT01-2588 (ICT-2588), a novel tumor-targeted vascular disrupting agent, in solvents including a potential buffered formulation containing 10% hydroxypropyl-β-cyclodextrin. The two hydrodynamic sizing techniques give measurement responses are that fundamentally different for aggregated solutions containing the target molecule, and the benefits of using TDA in conjunction with DLS are that systems are characterised through measurement of both mass- and z-average hydrodynamic radii...
February 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28180989/development-of-a-new-colorimetric-assay-for-detection-of-bisphenol-a-in-aqueous-media-using-green-synthesized-silver-chloride-nanoparticles-experimental-and-theoretical-study
#7
Shiva Khalililaghab, Safieh Momeni, Maryam Farrokhnia, Iraj Nabipour, Sadegh Karimi
In the present study, a cost-effective, green and simple synthesis method was applied for preparation of stable silver chloride nanoparticles (AgCl-NPs). The method was done by forming AgCl-NPs from Ag(+) ions using aqueous extract of brown algae (Sargassum boveanum) obtained from the Persian Gulf Sea. This extract served as capping agent during the formation of AgCl-NPs. Creation of AgCl-NPs was confirmed by UV-visible spectroscopy, powder X-ray diffraction, energy-dispersive X-ray spectroscopy, and high-resolution transmission electron microscopy, while the morphology and size analyses were characterized using high-resolution transmission electron microscopy and dynamic light scattering...
February 8, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28179572/spectrin-%C3%AE-v-adaptive-mutations-and-changes-in-subcellular-location-correlate-with-emergence-of-hair-cell-electromotility-in-mammalians
#8
Matteo Cortese, Samantha Papal, Francisco Pisciottano, Ana Belén Elgoyhen, Jean-Pierre Hardelin, Christine Petit, Lucia Florencia Franchini, Aziz El-Amraoui
The remarkable hearing capacities of mammals arise from various evolutionary innovations. These include the cochlear outer hair cells and their singular feature, somatic electromotility, i.e., the ability of their cylindrical cell body to shorten and elongate upon cell depolarization and hyperpolarization, respectively. To shed light on the processes underlying the emergence of electromotility, we focused on the βV giant spectrin, a major component of the outer hair cells' cortical cytoskeleton. We identified strong signatures of adaptive evolution at multiple sites along the spectrin-βV amino acid sequence in the lineage leading to mammals, together with substantial differences in the subcellular location of this protein between the frog and the mouse inner ear hair cells...
February 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28165020/a-potent-synthetic-inorganic-antibiotic-with-activity-against-drug-resistant-pathogens
#9
Shelby Hubick, Arumugam Jayaraman, Alexander McKeen, Shelby Reid, Jane Alcorn, John Stavrinides, Brian T Sterenberg
The acronymously named "ESKAPE" pathogens represent a group of bacteria that continue to pose a serious threat to human health, not only due to their propensity for repeated emergence, but also due to their ability to "eskape" antibiotic treatment. The evolution of multi-drug resistance in these pathogens alone has greatly outpaced the development of new therapeutics, necessitating an alternative strategy for antibiotic development that considers the evolutionary mechanisms driving antibiotic resistance. In this study, we synthesize a novel inorganic antibiotic, phosphopyricin, which has antibiotic activity against the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE)...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163981/current-advances-in-5-aminolevulinic-acid-mediated-photodynamic-therapy
#10
Connor Thunshelle, Rui Yin, Qiquan Chen, Michael R Hamblin
Kennedy and Pottier discovered that photodynamic therapy (PDT) could be carried out using a procedure consisting of topical application of the porphyrin-precursor, 5-aminolevulinic acid (ALA) to the skin, followed after some time by illumination with various light parameters in the 1980s. Since then, ALA-PDT has expanded enormously and now covers most aspects of dermatological disease. The purpose of this review is to discuss a range of ingenious strategies that investigators have devised for improving the overall outcome (higher efficiency and lower side effects) of ALA-PDT...
September 2016: Current Dermatology Reports
https://www.readbyqxmd.com/read/28160831/-glioblastoma-innovations-in-surgery
#11
Thiebaud Picart, Jacques Guyotat
One of the innovative principles in glioblastoma surgery consists in making the tumour fluorescent in order for it to be more easily visualised during the procedure. 5-aminolevulinic acid (5-ALA) undergoes an enzyme transformation, turning into another molecule, protoporphyrine IX (PPIX) whose property is fluorescence. It emits red light when it is stimulated by blue light.
February 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28159198/what-is-the-budget-impact-of-a-new-treatment-or-new-health-technology-arriving-on-the-market
#12
Benoit Dervaux, Camille Le Fur, Sophie Dubois, Anne Josseran
In France, market access for innovative drugs (level I, II & III improvement of medical service rendered having significant impact on health insurance expenditure) involves medico-economic evaluation. In addition to cost-effectiveness analysis (CEA), budget impact analysis (BIA) can be performed, especially since the sustainability of the health insurance system has become a growing concern for all stakeholders. The members of the Giens 2016 round table discussed the contribution of BIA based on a review of the literature on distribution models, the participants' experiences including experience related to the modalities of hospital assessments, and examples from other countries...
December 31, 2016: Thérapie
https://www.readbyqxmd.com/read/28157258/remote-regulation-of-membrane-channel-activity-by-site-specific-localization-of-lanthanide-doped-upconversion-nanocrystals
#13
Xiangzhao Ai, Linna Lyu, Yang Zhang, Yanxia Tang, Jing Mu, Fang Liu, Yixi Zhou, Zhenghong Zuo, Gang Liu, Bengang Xing
The spatiotemporal regulation of light-gated ion channels is a powerful tool to study physiological pathways and develop personalized theranostic modalities. So far, most existing light-gated channels are limited by their action spectra in the ultraviolet (UV) or visible region. Simple and innovative strategies for the specific attachment of photoswitches on the cell surface without modifying or genetically encoding channel structures, and more importantly, that enable the remote activation of ion-channel functions within near-infrared (NIR) spectral window in living systems, remain a challenging concern...
February 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28142312/coherent-light-sources-at-the-nanoscale
#14
Ankun Yang, Danqing Wang, Weijia Wang, Teri W Odom
This review focuses on coherent light sources at the nanoscale, and specifically on lasers exploiting plasmonic cavities that can beat the diffraction limit of light. Conventional lasers exhibit coherent, intense, and directional emission with cavity sizes much larger than their operating wavelength. Plasmon lasers show ultrasmall mode confinement, support strong light-matter interactions, and represent a class of devices with extremely small sizes. We discuss the differences between plasmon lasers and traditional ones, and we highlight advances in directionality and tunability through innovative cavity designs and new materials...
January 30, 2017: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/28132556/pre-registration-clinical-skills-development-and-curriculum-change
#15
Jo Rutt
This article outlines and offers an overview of the process of curriculum change and the development and integration of clinical skills. The focus on clinical skills in the essential skills clusters annexe set by the Nursing and Midwifery Council requires innovative strategies in theoretical aspects of the nursing programme to be identified. Based on the constructivist philosophy of curriculum design and in light of the ever-changing healthcare environment, a blended-learning approach was developed for the delivery of clinical skills...
January 26, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28132512/cardiac-light-chain-amyloidosis-the-role-of-metal-ions-in-oxidative-stress-and-mitochondrial-damage
#16
Luisa Diomede, Margherita Romeo, Paola Rognoni, Marten Beeg, Claudia Foray, Elena Ghibaudi, Giovanni Palladini, Robert Alan Cherny, Laura Verga, Gian Luca Capello, Vittorio Perfetti, Fabio Fiordaliso, G Merlini, Mario Salmona
<b>Aims: </b>The knowledge of the mechanism underlying the cardiac damage in immunoglobulin light chain (LC) amyloidosis (AL) is essential to develop novel therapies and improve patients' outcome. Although an active role of radical oxygen species (ROS) in LC-induced cardiotoxicity has already been envisaged, the actual mechanisms behind their generation remain elusive. This study was aimed at further dissecting the action of ROS generated by cardiotoxic LC in vivo and investigating whether transition metal ions are involved in this process...
January 28, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28128787/an-invisible-student-population-accommodating-and-serving-college-students-with-lupus
#17
Neelam Agarwal, Vinod Kumar
BACKGROUND: Systemic Lupus Erythematosus (SLE), or lupus, is a chronic autoimmune disorder. Individuals with lupus face unique psychosocial and emotional challenges such as living with the unpredictability of the disease, symptoms such as fatigue, pain and depression, anxiety, cognitive problems, and coping with stress. OBJECTIVE: This article will attempt to shed light on the role that lupus plays in the lives of college students in their academics and other unique psychosocial needs...
January 23, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28126379/use-of-eye-tracking-as-an-innovative-instructional-method-in-surgical-human-anatomy
#18
María Luísa Sánchez-Ferrer, María Dolores Grima-Murcia, Francisco Sánchez-Ferrer, Ana Isabel Hernández-Peñalver, Eduardo Fernández-Jover, Francisco Sánchez Del Campo
OBJECTIVE: Tobii glasses can record corneal infrared light reflection to track pupil position and to map gaze focusing in the video recording. Eye tracking has been proposed for use in training and coaching as a visually guided control interface. The aim of our study was to test the potential use of these glasses in various situations: explanations of anatomical structures on tablet-type electronic devices, explanations of anatomical models and dissected cadavers, and during the prosection thereof...
January 23, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28120867/high-quality-bioreplication-of-intricate-nanostructures-from-a-fragile-gecko-skin-surface-with-bactericidal-properties
#19
David William Green, Kenneth Ka-Ho Lee, Jolanta Anna Watson, Hyun-Yi Kim, Kyung-Sik Yoon, Eun-Jung Kim, Jong-Min Lee, Gregory Shaun Watson, Han-Sung Jung
The external epithelial surfaces of plants and animals are frequently carpeted with small micro- and nanostructures, which broadens their adaptive capabilities in challenging physical habitats. Hairs and other shaped protuberances manage with excessive water, light contaminants, predators or parasites in innovative ways. We are interested in transferring these intricate architectures onto biomedical devices and daily-life surfaces. Such a project requires a very rapid and accurate small-scale fabrication process not involving lithography...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118098/performance-ratio-based-resource-allocation-decision-making-in-genomic-medicine
#20
Vasilios Fragoulakis, Christina Mitropoulou, Daphne Katelidou, Ron H van Schaik, Nikolaos Maniadakis, George P Patrinos
In modern healthcare systems, the available resources may influence the morbidity, mortality, and-consequently-the level of healthcare provided in every country. This is of particular interest in developing countries where the resources are limited and must be spent wisely to address social justice and the right for equal access in healthcare services by all the citizens in economically viable terms. In this light, the current allocation is, in practice, inefficient and rests mostly on each country's individual political and historical context and, thus, does not always incorporate decision-making enabled by economic models...
February 2017: Omics: a Journal of Integrative Biology
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