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innovation of light

Letitia H Burridge, Michele M Foster, Maria Donald, Jianzhen Zhang, Anthony W Russell, Claire L Jackson
As the prevalence of type 2 diabetes continues to escalate, health system reform is seeking better patient outcomes through new models of care that aim to provide the most appropriate care when needed. Patients' experiences of service innovations can shed light on the successes and challenges of implementing change. This paper explores patients' views of a new model of integrated care for patients with type 2 diabetes. A mixed-methods, randomised control trial evaluated a beacon clinic model of care for complex type 2 diabetes led by specialist general practitioners (GPs) in primary care settings in Brisbane, Australia...
October 26, 2016: Health & Social Care in the Community
Na Liu, Ruixiang Qu, Yuning Chen, Yingze Cao, Weifeng Zhang, Xin Lin, Yen Wei, Lin Feng, Lei Jiang
Dual purification of both oily wastewater and dye-polluted water for enhancing the use of freshwater is an urgent task. We report herein, the facile synthesis of inorganic semiconductor nanomaterials anchored mesh for in situ dual-functional water purification. This resultant mesh combines the excellent capacity of oil removal and the advantage of photocatalytic performance for dye degradation under visible light irradiation at the same time. In addition, the mesh was easily regenerated and remained unaltered in photocatalytic performance over five successive dye degradation cycles...
October 26, 2016: Nanoscale
Hang Ruan, Zhixi Su, Xun Gu
Recent innovation of RNA-seq technology has shed insightful light on the transcriptomic evolution studies, especially on researches of tissue-specific expression evolution. Phylogenetic analysis of transcriptome data may help to identify causal gene expression differences underlying the evolutionary changes in morphological, physiological, and developmental characters of interest. However, there is a deficiency of software to phylogenetically analyze transcriptome data. To address this need, we have developed an R package TreeExp that can perform comparative expression evolution analysis based on RNA-seq data, which includes optimized input formatting, normalization, pairwise expression distance estimation, expression character tree inference, and preliminary expression phylogenetic network analysis...
October 26, 2016: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
Tânia F C V Silva, Petrick A Soares, Diego R Manenti, Amélia Fonseca, Isabel Saraiva, Rui A R Boaventura, Vítor J P Vilar
In this work, an innovative methodology for the treatment of landfill leachates, after aerobic lagooning, is proposed and adjusted at pilot-scale. This methodology involves an aerobic activated sludge biological pre-oxidation (ASBO), a coagulation/sedimentation step (240mgFe(3+)/L, at pH4.2) and a photo-oxidation through a photo-Fenton (PF) reaction (60mg Fe(2+), at pH2.8) combining solar and artificial light. The ASBO process applied to a leachate after aerobic lagooning, with high organic and nitrogen content (1...
October 22, 2016: Science of the Total Environment
Svetlana A Chechetka, Motomichi Doi, Benoit P Pichon, Sylvie Bégin-Colin, Eijiro Miyako
Stimulating cells by light is an attractive technology to investigate cellular function and deliver innovative cell-based therapy. However, current techniques generally use poorly biopermeable light, which prevents broad applicability. Here, we show that a new type of composite nanomaterial, synthesized from multi-walled carbon nanotubes, magnetic iron nanoparticles, and polyglycerol, enables photothermal and mechanical control of Ca(2+) influx into cells overexpressing transient receptor potential vanilloid type-2...
November 25, 2016: Nanotechnology
Jim Junhui Huang, Gagarin Bunjamin, Edwin Sianguan Teo, Deric Boonhuat Ng, Yuan Kun Lee
BACKGROUND: The design of photobioreactor (PBR) for outdoor mass cultivation of microalgae determines the distribution of solar irradiance among cells in the culture, mode of agitation, mass transfer efficacy, and energy consumption, thus determines the productivity of the system and the cost of production. In this study, the concept of a floating photobioreactor with rotation function is proposed. Dunaliella tertiolecta, a model microalga, cultured in the attached vessels was evaluated...
2016: Biotechnology for Biofuels
Hong Ji, Jocelyn M Biagini Myers, Eric B Brandt, Cole Brokamp, Patrick H Ryan, Gurjit K Khurana Hershey
Exposure to traffic-related air pollution (TRAP) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant as large segments of the global population resides in zones that are most impacted by TRAP and schools are often located in high TRAP exposure areas. Recent findings shed new light on the epigenetic mechanisms by which exposure to traffic pollution may contribute to the development and persistence of asthma. In order to delineate TRAP induced effects on the epigenome, utilization of newly available innovative methods to assess and quantify traffic pollution will be needed to accurately quantify exposure...
2016: Allergy, Asthma, and Clinical Immunology
Jean-Baptiste Tylcz, Thierry Bastogne, Alexia Bourguignon, Celine Frochot, Muriel Barberi-Heyob
: Photodynamic therapy (PDT) is an alternative treatment for cancer that involves the administration of a photosensitizing agent, which is activated by light at a specific wavelength. This illumination causes after a sequence of photoreactions, the production of reactive oxygen species responsible for the death of the tumor cells but also the degradation of the photosensitizing agent, which then loose the fluorescence properties. The phenomenon is commonly known as photobleaching process and can be considered as a therapy efficiency indicator...
October 21, 2016: IEEE Transactions on Bio-medical Engineering
J Lagarde, M Sarazin
Frontotemporal degeneration (FTD) in its behavioral variant (bvFTD) is probably one of the conditions that best illustrates the links between psychiatry and neurology. It is indeed admitted that between a third and half of patients with this condition, especially in early-onset forms, receive an initial diagnosis of psychiatric disorder (depression, schizophrenia, bipolar disorder) and are then referred to a psychiatric ward. BvFTD can thus be considered a neurological disorder with a psychiatric presentation...
October 20, 2016: L'Encéphale
Troy A Skwor, Stephanie Klemm, Hanyu Zhang, Brianna Schardt, Stephanie Blaszczyk, Matthew A Bork
Increasing rates of antibiotic resistance coupled with the lack of novel antibiotics threatens proper clinical treatment and jeopardizes their use in prevention. A photodynamic approach appears to be an innovative treatment option, even for multi-drug resistant strains of bacteria. Three components are utilized in photodynamic inactivation: a photosensitizer, light source, and oxygen. Variations in photosensitizers strongly influence microbial binding and bactericidal activity. In this study, four different cationic metalloporphyrins (Cu(2+), Fe(2+), Pd(2+), Zn(2+)) were compared to the free-base ligand 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)porphyrin regarding their electronic properties and generation of reactive oxygen species upon subsequent 405nm violet-blue irradiation...
October 15, 2016: Journal of Photochemistry and Photobiology. B, Biology
Antoine Prandota Trzcinski, Lily Ganda, Chinagarn Kunacheva, Dong Qing Zhang, Li Leonard Lin, Guihe Tao, Yingjie Lee, Wun Jern Ng
In light of global warming mitigation efforts, increasing sludge disposal costs, and need for reduction in the carbon footprint of wastewater treatment plants, innovation in treatment technology has been tailored towards energy self-sufficiency. The AB process is a promising technology for achieving maximal energy recovery from wastewaters with minimum energy expenditure and therefore inherently reducing excess sludge production. Characterization of this novel sludge and its comparison with the more conventional B-stage sludge are necessary for a deeper understanding of AB treatment process design...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
David S Freedman, Joseph B Schroeder, Gregory I Telian, Zhengyang Zhang, Smrithi Sunil, Jason T Ritt
OBJECTIVE: Behavioral neuroscience studies in freely moving rodents require small, light-weight implants to facilitate neural recording and stimulation. Our goal was to develop an integrated package of 3D printed parts and assembly aids for labs to rapidly fabricate, with minimal training, an implant that combines individually positionable microelectrodes, an optical fiber, zero insertion force (ZIF-clip) headstage connection, and secondary recording electrodes, e.g. for electromyography (EMG)...
October 20, 2016: Journal of Neural Engineering
Michael A Stevenson
Vaccines were once produced almost exclusively by state-supported entities. While they remain essential tools for public health protection, the majority of the world's governments have allowed industry to assume responsibility for this function. This is significant because while the international harmonisation of quality assurance standards have effectively increased vaccine safety, they have also reduced the number of developing country vaccine producers, and Northern multinational pharmaceutical companies have shown little interest in offering the range of low-priced products needed in low and middle-income-country contexts...
October 19, 2016: Global Public Health
Elisa Tardelli, Sara Mazzarri, Domenico Rubello, Marta Gennaro, Lorenzo Fantechi, Valerio Duce, Antonella Romanini, Sotirios Chondrogiannis, Duccio Volterrani, Patrick M Colletti, Gianpiero Manca
Melanoma is an important public health problem, and its incidence is increasing worldwide. The disease status of regional lymph nodes is the most important prognostic factor in early-stage melanoma patients. Sentinel lymph node biopsy (SLNB) was introduced in the early 1990s as a less invasive procedure than complete lymph node dissection to allow histopathologic evaluation of the "sentinel lymph node" (SLN), which is the first node along the lymphatic pathway from a primary tumor. Sentinel lymph node biopsy has minimal complication risks compared with standard complete lymph node dissection...
October 5, 2016: Clinical Nuclear Medicine
Shih-Wei Su, Zhen-Kai Lu, Shih-Chuan Gou, Wen-Te Liao
Cavity quantum electrodynamics (CQED) has played a central role in demonstrating the fundamental principles of the quantum world, and in particular those of atom-light interactions. Developing fast, dynamical and non-mechanical control over a CQED system is particularly desirable for controlling atomic dynamics and building future quantum networks at high speed. However conventional mirrors do not allow for such flexible and fast controls over their coupling to intracavity atoms mediated by photons. Here we theoretically investigate a novel all-optical CQED system composed of a binary Bose-Einstein condensate (BEC) sandwiched by two atomic ensembles...
October 17, 2016: Scientific Reports
P C Paula, J T A Oliveira, D O B Sousa, B G T Alves, A F U Carvalho, O L Franco, I M Vasconcelos
Various plant species have long been used in traditional medicine worldwide to treat diabetes. Among the plant-based compounds with hypoglycemic properties, studies on insulin-like proteins isolated from leaves, fruits and seeds are rarely reported in the relevant literature. Our research group has been investigating the presence of insulin-like proteins in Moringa oleifera, a plant species native to India, and we have obtained a leaf protein isolate and semi-purified derived fractions, as well as a seed coat protein fraction (Mo-SC), with hypoglycemic activity in chemically induced diabetic mice that have increased tolerance to orally administered glucose...
October 10, 2016: New Biotechnology
Patrícia Santos, Ana P Herrmann, Radharani Benvenutti, Guilherme Noetzold, Franciele Giongo, Clarissa S Gama, Angelo L Piato, Elaine Elisabetsky
Anxiety disorders are highly prevalent and often result in poor quality of life. Available anxiolytics show significant adverse effects as well as partial efficacy in a sizable part of patients. Innovative treatments with more favorable risk-benefit ratio are sorely needed. A growing body of clinical data indicates the benefits of N-acetylcysteine (NAC) in psychiatric conditions. NAC modulates antioxidant, glutamatergic, inflammatory and neurotrophic pathways in the central nervous system, all of which are relevant to anxiety pathology...
October 7, 2016: Behavioural Brain Research
Guolong Wang, Guowei Lv, Shihu Zhang, Jinyou Shao, Xiangming Li, Hongmiao Tian, Demei Yu, Lifeng Zhang
This communication describes an innovative photocurable leaky dielectric for electrohydrodynamic patterning (EHDP). Based on the well-designed molecular structure, the material in its liquid state exhibits low viscosity, high homogeneity, and more importantly a leaky dielectric characteristic; meanwhile, UV light irradiation transforms it from a liquid leaky dielectric into a solid perfect dielectric instantaneously via an interfacial reaction. Two typical EHDP processes have confirmed that the beneficial properties of this material help to rapidly fulfill a higher aspect ratio and/or smaller feature size patterning compared to its perfect dielectric counterpart...
September 20, 2016: Soft Matter
Min-Rui Gao, Jiayin Yuan, Markus Antonietti
Ionic liquids (ILs) are new, innovative ionic solvents with rich physicochemical properties and intriguing pre-organized solvent structures, which offer great potentials to impact across versatile areas of scientific research, for example, the synthetic inorganic chemistry. Recent use of ILs as precursors, templates, and solvents has led to inorganic materials with tailored sizes, dimensionalities, morphologies and functionalities that are difficultly, or even not accessible, with conventional solvents. Poly(ionic liquid)s (PILs) polymerized from ILs monomers also raise the prospect of modifying nucleation, growth and crystallization of inorganic objects, shedding light on the synthesis of a wide range of new materials...
October 6, 2016: Chemistry: a European Journal
Annette Feuchtinger, Axel Walch, Michael Dobosz
This review delves into the rapidly evolving field of deep tissue imaging at cellular resolution, reviewing popular tissue clearing and staining methods in combination with light-sheet fluorescence microscopy (LSFM) including quantification and three-dimensional visualization tools, the field of applications and perspective, particularly with the focus on preclinical cancer research and drug development. The LSFM technique presented here allows an extremely fast optical sectioning for three-dimensional reconstruction of centimeter-sized tissue samples at cellular resolution...
October 4, 2016: Histochemistry and Cell Biology
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