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https://www.readbyqxmd.com/read/28108959/innovative-root-end-filling-materials-based-on-calcium-silicates-and-calcium-phosphates
#1
Ali Abedi-Amin, Arlinda Luzi, Massimo Giovarruscio, Gaetano Paolone, Atanaz Darvizeh, Victoria Vivó Agulló, Salvatore Sauro
This in vitro study evaluated the apical sealing ability, bioactivity and biocompatibility of an experimental calcium silicate-based and two light-curing calcium silicate/calcium-phosphate cements as potential root end filling materials. A calcium silicate Portland-based (Control PC), an experimental calcium silicate (Exp. PC) and two light-curing cements (LC-CaP; LC-Si/CaP) were assessed for their alkalinising activity (pH) and biocompatibility. Single-rooted human canines were endodontically treated, filled with gutta-percha and finally submitted to apicoectomy...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28104380/-evolutionary-medicine-a-new-look-on-health-and-disease
#2
F Bauduer
Evolutionary medicine represents an innovative approach deriving from evolutionary biology. It includes the initial Darwin's view, its actualization in the light of progresses in genetics and also dissident theories (i.e. non gene-based) particularly epigenetics. This approach enables us to reconsider the pathophysiology of numerous diseases, as for instance, infection, and our so-called diseases of civilization especially obesity, type 2 diabetes, allergy or cancer. Evolutionary medicine may also improve our knowledge regarding inter-individual variation in susceptibility to disease or drugs...
January 16, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28094261/beyond-the-margins-real-time-detection-of-cancer-using-targeted-fluorophores
#3
REVIEW
Ray R Zhang, Alexandra B Schroeder, Joseph J Grudzinski, Eben L Rosenthal, Jason M Warram, Anatoly N Pinchuk, Kevin W Eliceiri, John S Kuo, Jamey P Weichert
Over the past two decades, synergistic innovations in imaging technology have resulted in a revolution in which a range of biomedical applications are now benefiting from fluorescence imaging. Specifically, advances in fluorophore chemistry and imaging hardware, and the identification of targetable biomarkers have now positioned intraoperative fluorescence as a highly specific real-time detection modality for surgeons in oncology. In particular, the deeper tissue penetration and limited autofluorescence of near-infrared (NIR) fluorescence imaging improves the translational potential of this modality over visible-light fluorescence imaging...
January 17, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28092053/sh2-domain-based-fret-biosensor-for-measuring-bcr-abl-activity-in-living-cml-cells
#4
Mari Fujioka, Yumi Asano, Shigeyuki Nakada, Yusuke Ohba
Fluorescent proteins (FPs) displaying distinct spectra have shed their light on a wide range of biological functions. Moreover, sophisticated biosensors engineered to contain single or multiple FPs, including Förster resonance energy transfer (FRET)-based biosensors, spatiotemporally reveal the molecular mechanisms underlying a variety of pathophysiological processes. However, their usefulness for applied life sciences has yet to be fully explored. Recently, our research group has begun to expand the potential of FPs from basic biological research to the clinic...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28088668/near-infrared-light-triggered-drug-delivery-system-for-higher-efficacy-of-combined-chemo-photothermal-treatment
#5
Yi Chen, Haohuan Li, Yueyang Deng, Haifeng Sun, Xue Ke, Tianyuan Ci
: The combination of chemotherapy and photothermal therapy is a promising strategy for cancer treatment. In the present study, indocyanine green (ICG), a widely used near-infrared (NIR) dye in photothermal therapy, and chemotherapeutic drug-doxorubicin (DOX) were loaded within the nanoparticles of novel designed arylboronic ester and cholesterol modified hyaluronic acid (PPE-Chol1-HA), denoted as PCH-DI. We take advantage of reactive oxygen species (ROS) production capability of ICG and ROS-sensitivity of arylboronic ester to realize controllable drug release...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28080301/assessing-social-cognition-age-related-changes-in-moral-reasoning-in-childhood-and-adolescence
#6
V Chiasson, E Vera-Estay, G Lalonde, J J Dooley, M H Beauchamp
OBJECTIVE: There is increasing recognition that socio-cognitive skills, such as moral reasoning (MR), are affected in a wide range of developmental and neuropsychological conditions. However, the lack of appropriate measures available to neuropsychologists poses a challenge for the direct assessment of these skills. This study sought to explore age-related changes in MR using an innovative visual tool and examine the developmental sensitivity of the task. METHOD: To address some of the methodological limitations of traditional measures of MR, a novel, visual task, the Socio-Moral Reasoning Aptitude Level (So-Moral), was used to evaluate MR in 216 healthy participants aged 6-20 years...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28078316/covert-narrative-capacity-mental-life-in-patients-thought-to-lack-consciousness
#7
Lorina Naci, Mackenzie Graham, Adrian M Owen, Charles Weijer
Despite the apparent absence of external signs of consciousness, a significant proportion of behaviorally nonresponsive patients can respond to commands by willfully modulating their brain activity. However, little is known about the mental life of these patients. We discuss a recent innovative approach, which sheds light on the preserved cognitive capacities of these patients, including executive function, theory of mind, and the experience of affective states. This research represents a fundamental shift in our understanding of these patients, and has important implications for both their continued treatment and care...
January 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28074220/biology-dynamics-and-applications-of-transposable-elements-in-basidiomycete-fungi
#8
REVIEW
Raúl Castanera, Alessandra Borgognone, Antonio G Pisabarro, Lucía Ramírez
The phylum Basidiomycota includes filamentous fungi and yeast species with different ecological and genomic characteristics. Transposable elements (TEs) are abundant components of most eukaryotic genomes, and their transition from being genomic parasites to key drivers of genomic architecture, functionality, and evolution is a subject receiving much attention. In light of the abundant genomic information released during the last decade, the aims of this mini-review are to discuss the dynamics and impact of TEs in basidiomycete fungi...
January 10, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28069384/regulation-of-cancerous-progression-and-epithelial-mesenchymal-transition-by-mir-34c-3p-via-modulation-of-map3k2-signaling-in-triple-negative-breast-cancer-cells
#9
Jiang Wu, Wei-Zhi Li, Mei-Ling Huang, Hong-Liang Wei, Ting Wang, Jing Fan, Nan-Lin Li, Rui Ling
Emerging but limited data have evidenced an essential involvement of microRNAs (miRNAs) in the development and progression of triple negative breast cancer (TNBC), which empowers these small regulators as an innovative therapeutic approach, especially for this unique tumor subgroup still lacking an efficient and specific therapeutic target. Herein, we reported the down-regulation of miR-34c-3p level in TNBC tissues, and its expression was closely associated with estrogen receptor alpha (ERα), but not other receptors, in well-characterized breast cancer (BCa) cells...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28067372/selective-turn-on-and-modulation-of-resonant-energy-transfer-in-single-plasmonic-hybrid-nanostructures
#10
Łukasz Bujak, Tatsuya Ishii, Dharmendar Kumar Sharma, Shuzo Hirata, Martin Vacha
Förster resonant energy transfer (FRET) is a nonradiative process by which the energy of light absorbed by a donor molecule is transferred to an acceptor molecule over a distance of several nanometers. FRET plays a crucial role in photosynthesis and nature-inspired artificial light-harvesting systems that are being explored for use in energy conversion applications. Localized plasmons of metal nanoparticles can potentially lead to a significant increase of FRET efficiency and effective donor-acceptor distance...
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28065328/use-of-personal-protective-equipment-among-health-care-personnel-results-of-clinical-observations-and-simulations
#11
JaHyun Kang, John M O'Donnell, Bonnie Colaianne, Nicholas Bircher, Dianxu Ren, Kenneth J Smith
BACKGROUND: Very little is known about how health care personnel (HCP) actually use personal protective equipment (PPE). METHODS: The clinical PPE practices of 50 HCP from selected units at the University of Pittsburgh Medical Center (UPMC) Presbyterian Hospital were videotaped with HCP consent. For 2 PPE simulation sessions (simple and full-body sets), 82 HCP were recruited throughout the UPMC system. Simulation practices were videotaped and examined using fluorescent powder with ultraviolet lighting...
January 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28059321/high-resolution-three-dimensional-flash-lidar-system-using-a-polarization-modulating-pockels-cell-and-a-micro-polarizer-ccd-camera
#12
Sungeun Jo, Hong Jin Kong, Hyochoong Bang, Jae-Wan Kim, Jomsool Kim, Soungwoong Choi
An innovative flash LIDAR (light detection and ranging) system with high spatial resolution and high range precision is proposed in this paper. The proposed system consists of a polarization modulating Pockels cell (PMPC) and a micro-polarizer CCD camera (MCCD). The Pockels cell changes its polarization state with respect to time after a laser pulse is emitted from the system. The polarization state of the laser-return pulse depends on the arrival time. The MCCD measures the intensity of the returning laser pulse to calculate the polarization state, which gives the range...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28056720/pilonidal-sinus-destruction-with-a-radial-laser-probe-technique-and-first-belgian-experience
#13
M Dessily, F Charara, S Ralea, J-L Allé
BACKGROUND: The treatment of pilonidal sinus disease still remains challenging. Despite many non-surgical and surgical methods, no consensus emerged for the best treatment. We describe a new innovative technique consisting in the destruction of the pilonidal cyst with a radial laser probe (FILAC(TM), Biolitec, Germany). The energy delivered causes the destruction of the sinus epithelium and the simultaneous obliteration of the tract. METHOD: In December 2015, we retrospectively studied the data of our 40 first patients operated with this technique between September 2014 and September 2015...
January 6, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28054445/anti-diabetic-activities-of-cis-and-trans-2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-glucopyranoside-from-polygonum-multiflorum
#14
Wenping Tang, Shiming Li, Yue Liu, Jia-Ching Wu, Min-Hsiung Pan, Mou-Tuan Huang, Chi-Tang Ho
SCOPE: Functional foods can be used alone or in combination with existing therapies in preventing and treating type 2 diabetes (T2D). Trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-glucopyranoside (trans-THSG), a dominant bioactive compound from Polygonum multiflorum (PM) - a popular medicinal food in Asia, has attracted increasing research interests due to its strong antioxidant activity. The content of naturally occurring cis-THSG (cis-2,3,5,4'-tetrahydroxystilbene 2-O-β-glucopyranoside) was very low in PM root, but was prepared in this research by mimicking the traditional process of PM...
January 5, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28042336/bivalent-brain-shuttle-increases-antibody-uptake-by-monovalent-binding-to-the-transferrin-receptor
#15
Greta Hultqvist, Stina Syvänen, Xiaotian T Fang, Lars Lannfelt, Dag Sehlin
The blood-brain barrier (BBB) is an obstacle for antibody passage into the brain, impeding the development of immunotherapy and antibody-based diagnostics for brain disorders. In the present study, we have developed a brain shuttle for active transport of antibodies across the BBB by receptor-mediated transcytosis. We have thus recombinantly fused two single-chain variable fragments (scFv) of the transferrin receptor (TfR) antibody 8D3 to the light chains of mAb158, an antibody selectively binding to Aβ protofibrils, which are involved in the pathogenesis of Alzheimer's disease (AD)...
2017: Theranostics
https://www.readbyqxmd.com/read/28039061/primary-angle-closure-glaucoma-what-we-know-and-what-we-don-t-know
#16
REVIEW
Xinghuai Sun, Yi Dai, Yuhong Chen, Dao-Yi Yu, Stephen J Cringle, Junyi Chen, Xiangmei Kong, Xiaolei Wang, Chunhui Jiang
Primary angle-closure glaucoma (PACG) is a common cause of blindness. Angle closure is a fundamental pathologic process in PAGC. With the development of imaging devices for the anterior segment of the eye, a better understanding of the pathogenesis of angle closure has been reached. Aside from pupillary block and plateau iris, multiple-mechanisms are more common contributors for closure of the angle such as choroidal thickness and uveal expansion, which may be responsible for the presenting features of PACG...
December 28, 2016: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28036021/monitoring-the-response-of-hyperbilirubinemia-in-the-mouse-brain-by-in-vivo-bioluminescence-imaging
#17
Isabella Manni, Giuliana Di Rocco, Salvatore Fusco, Lucia Leone, Saviana Antonella Barbati, Carmine Maria Carapella, Claudio Grassi, Giulia Piaggio, Gabriele Toietta
Increased levels of unconjugated bilirubin are neurotoxic, but the mechanism leading to neurological damage has not been completely elucidated. Innovative strategies of investigation are needed to more precisely define this pathological process. By longitudinal in vivo bioluminescence imaging, we noninvasively visualized the brain response to hyperbilirubinemia in the MITO-Luc mouse, in which light emission is restricted to the regions of active cell proliferation. We assessed that acute hyperbilirubinemia promotes bioluminescence in the brain region, indicating an increment in the cell proliferation rate...
December 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28032849/reflections-on-a-decade-of-face-transplantation
#18
Giorgio Giatsidis, Indranil Sinha, Bohdan Pomahac
On November 27, 2005, Isabelle Dinoire underwent the world's first partial face transplant in Amiens (France) after a dog attack had left her face severely disfigured. The abrupt surgical leap found the medical community and society unprepared to deal with the scientific, ethical, and societal implications of a surgical procedure that was striving to transition from sci-fi novels to science. Today, 10 years and over 35 transplants later, public opinion has become accustomed to the concept of "face restoration" through transplantation...
April 26, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28026067/fuel-free-synthetic-micro-nanomachines
#19
Tailin Xu, Wei Gao, Li-Ping Xu, Xueji Zhang, Shutao Wang
Inspired by the swimming of natural microorganisms, synthetic micro-/nanomachines, which convert energy into movement, are able to mimic the function of these amazing natural systems and help humanity by completing environmental and biological tasks. While offering autonomous propulsion, conventional micro-/nanomachines usually rely on the decomposition of external chemical fuels (e.g., H2 O2 ), which greatly hinders their applications in biologically relevant media. Recent developments have resulted in various micro-/nanomotors that can be powered by biocompatible fuels...
December 27, 2016: Advanced Materials
https://www.readbyqxmd.com/read/28018390/emerging-technologies-for-the-production-of-renewable-liquid-transport-fuels-from-biomass-sources-enriched-in-plant-cell-walls
#20
REVIEW
Hwei-Ting Tan, Kendall R Corbin, Geoffrey B Fincher
Plant cell walls are composed predominantly of cellulose, a range of non-cellulosic polysaccharides and lignin. The walls account for a large proportion not only of crop residues such as wheat straw and sugarcane bagasse, but also of residues of the timber industry and specialist grasses and other plants being grown specifically for biofuel production. The polysaccharide components of plant cell walls have long been recognized as an extraordinarily large source of fermentable sugars that might be used for the production of bioethanol and other renewable liquid transport fuels...
2016: Frontiers in Plant Science
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