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https://www.readbyqxmd.com/read/28927933/azopolymer-photopatterning-for-directional-control-of-angiogenesis
#1
Chiara Fedele, Maria De Gregorio, Paolo A Netti, Silvia Cavalli, Chiara Attanasio
Understanding cellular behavior in response to microenvironmental stimuli is central to tissue engineering. An increasing number of reports emphasize the high sensitivity of cells to the physical characteristics of the surrounding milieu and in particular, topographical cues. In this work, we investigated the influence of dynamic topographic signal presentation on sprout formation and the possibility to obtain a space-time control over sprouting directionality without growth factors, in order to investigate the contribution of just topography in the angiogenic process...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28926867/diabetes-associated-biobanking-more-topical-than-ever
#2
Katharina Lydia Kynast, Nadine Volk, Thomas Fleming, Esther Herpel
The increasing prevalence of diabetes and its accompanying long-term complications, as well as the associated economic burden, calls for a rapid clinical translation of biomedical research to better valid the physiological relevance of the findings from basic research. To meet this condition, the Collaborative Research Center (CRC) 1118 has established the first nationwide diabetes-specific Biomaterialbank (BMB) that permanently preserves solid and liquid specimen retro- and prospectively at the Institute of Pathology and Department of Endocrinology of the University Hospital Heidelberg...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926278/planar-optical-nano-antennas-resolve-cholesterol-dependent-nanoscale-heterogeneities-in-the-plasma-membrane-of-living-cells
#3
Raju Regmi, Pamina Martina Winkler, Valentin Flauraud, Kyra Borgman, Carlo Manzo, Juergen Brugger, Herve Rigneault, Jerome Wenger, Maria F Garcia-Parajo
Optical nano-antennas can efficiently confine light into nanoscopic hotspots enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers a versatile platform to investigate the dynamics of individual biomolecules in living cell membranes and their partitioning into cholesterol-dependent lipid nanodomains. Here, we present optical nano-antenna arrays with accessible surface hotspots to study the characteristic diffusion dynamics of phosphoethanolamine (PE) and sphingomyelin (SM) in the plasma membrane of living cells at the nanoscale...
September 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28922593/cysteine-silac-mass-spectrometry-enables-the-identification-and-quantitation-of-scrambled-inter-chain-disulfide-bonds-preservation-of-native-heavy-light-chain-pairing-in-bispecific-iggs-generated-by-controlled-fab-arm-exchange
#4
Ewald T J van den Bremer, Aran F Labrijn, Ramon van den Boogaard, Patrick Priem, Kai Scheffler, Joost P M Melis, Janine Schuurman, Paul Parren, Rob N de Jong
Bispecific antibodies (bsAbs) are one of the most versatile and promising pharmaceutical innovations for countering heterogeneous and refractory disease by virtue of their ability to bind two distinct antigens. One critical quality attribute of bsAb formation requiring investigation is the potential randomization of cognate heavy chain (H)/light (L) chain pairing, which could occur to a varying extent dependent on bsAb format and the production platform. To assess the content of such HL chain-swapped reaction products with high sensitivity, we developed cysteine-SILAC, a method that facilitates the detailed characterization of disulfide-bridged peptides by mass-spectrometry...
September 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28920434/ultralow-temperature-solution-processed-aluminum-oxide-dielectrics-via-local-structure-control-of-nanoclusters
#5
Jeong-Wan Jo, Yong-Hoon Kim, Joohyung Park, Jae Sang Heo, Seongpil Hwang, Won-June Lee, Myung-Han Yoon, Myung-Gil Kim, Sung Kyu Park
Oxide dielectric materials play a key role in a wide range of high-performance solid-state electronics from semiconductor devices to emerging wearable and soft bio-electronic devices. Although lots of previous advances are noteworthy, their typical processing temperature still far exceeds the thermal limitations of soft materials, impeding their wide utilization in these emerging fields. Here, we report an innovative route to form highly reliable aluminum-oxide dielectric films using an ultralow temperature (< 60 ˚C) solution process with a class of oxide nanocluster precursors...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28911350/applying-the-care-group-model-to-tuberculosis-control-findings-from-a-community-based-project-in-mozambique
#6
A Brown, P Ernst, A Cambule, M Morrow, D Dortzbach, J E Golub, H B Perry
BACKGROUND: We describe the effectiveness of an innovative community-based social mobilization approach called Care Groups to improve the effectiveness of the national tuberculosis (TB) program by increasing TB testing and improving treatment outcomes in six districts of rural Mozambique. METHODS: The Care Group approach, which was implemented in a population of 218 191, enabled a facilitator to meet every 6 months with 10-12 community health volunteers (forming a Care Group) to share key TB messages and then for them to convey these messages over the subsequent 6 months to 10-12 households...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28906446/a-novel-low-power-consumption-all-fiber-optic-anemometer-with-simple-system-design
#7
Yang Zhang, Fang Wang, Zhihui Duan, Zexu Liu, Zigeng Liu, Zhenlin Wu, Yiying Gu, Changsen Sun, Wei Peng
A compact and low-power consuming fiber-optic anemometer based on single-walled carbon nanotubes (SWCNTs) coated tilted fiber Bragg grating (TFBG) is presented. TFBG as a near infrared in-fiber sensing element is able to excite a number of cladding modes and radiation modes in the fiber and effectively couple light in the core to interact with the fiber surrounding mediums. It is an ideal in-fiber device used in a fiber hot-wire anemometer (HWA) as both coupling and sensing elements to simplify the sensing head structure...
September 14, 2017: Sensors
https://www.readbyqxmd.com/read/28902843/the-apostasia-genome-and-the-evolution-of-orchids
#8
Guo-Qiang Zhang, Ke-Wei Liu, Zhen Li, Rolf Lohaus, Yu-Yun Hsiao, Shan-Ce Niu, Jie-Yu Wang, Yao-Cheng Lin, Qing Xu, Li-Jun Chen, Kouki Yoshida, Sumire Fujiwara, Zhi-Wen Wang, Yong-Qiang Zhang, Nobutaka Mitsuda, Meina Wang, Guo-Hui Liu, Lorenzo Pecoraro, Hui-Xia Huang, Xin-Ju Xiao, Min Lin, Xin-Yi Wu, Wan-Lin Wu, You-Yi Chen, Song-Bin Chang, Shingo Sakamoto, Masaru Ohme-Takagi, Masafumi Yagi, Si-Jin Zeng, Ching-Yu Shen, Chuan-Ming Yeh, Yi-Bo Luo, Wen-Chieh Tsai, Yves Van de Peer, Zhong-Jian Liu
Constituting approximately 10% of flowering plant species, orchids (Orchidaceae) display unique flower morphologies, possess an extraordinary diversity in lifestyle, and have successfully colonized almost every habitat on Earth. Here we report the draft genome sequence of Apostasia shenzhenica, a representative of one of two genera that form a sister lineage to the rest of the Orchidaceae, providing a reference for inferring the genome content and structure of the most recent common ancestor of all extant orchids and improving our understanding of their origins and evolution...
September 13, 2017: Nature
https://www.readbyqxmd.com/read/28901596/merging-arts-and-bioethics-an-interdisciplinary-experiment-in-cultural-and-scientific-mediation
#9
Vincent Couture, Jean-Christophe Bélisle-Pipon, Marianne Cloutier, Catherine Barnabé
How to engage the public in a reflection on the most pressing ethical issues of our time? What if part of the solution lies in adopting an interdisciplinary and collaborative strategy to shed light on critical issues in bioethics? An example is Art + Bioéthique, an innovative project that brought together bioethicists, art historians and artists with the aim of expressing bioethics through arts in order to convey the "sensitive" aspect of many health ethics issues. The aim of this project was threefold: 1) to identify and characterize mechanisms for the meeting of arts and bioethics; 2) to experiment with and co-construct a dialogue between arts and bioethics; and 3) to initiate a public discussion on bioethical issues through the blending of arts and bioethics...
October 2017: Bioethics
https://www.readbyqxmd.com/read/28893170/recent-progress-in-chaplaincy-related-research
#10
George Fitchett
In light of the continued growth of chaplaincy-related research this paper presents an overview of important findings. The review summarizes research in six broad areas: what chaplains do; the importance of religion and spiritual care to patients and families; the impact of chaplains' spiritual care on the patient experience; the impact of chaplain care on other patient outcomes; spiritual needs and chaplain care in palliative and end of life care; and chaplain care for staff colleagues. It concludes with a description of several innovative and important new studies of chaplain care and notes areas for future investigation...
September 2017: Journal of Pastoral Care & Counseling: JPCC
https://www.readbyqxmd.com/read/28892036/an-integrated-system-to-remotely-trigger-intracellular-signal-transduction-by-upconversion-nanoparticle-mediated-kinase-photoactivation
#11
Hua-De Gao, Pounraj Thanasekaran, Tzu-Ho Chen, Yu-Hsu Chang, Yu-Ju Chen, Hsien-Ming Lee
Upconversion nanoparticle (UCNP)-mediated photoactivation is a new approach to remotely control bioeffectors with much less phototoxicity and with deeper tissue penetration. However, the existing instrumentation on the market is not readily compatible with upconversion application. Therefore, modifying the commercially available instrument is essential for this research. In this paper, we first illustrate the modifications of a conventional fluorimeter and fluorescence microscope to make them compatible for photon upconversion experiments...
August 30, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28892016/cleair-monitoring-system-for-particulate-matter-a-case-in-the-napoleonic-museum-in-rome
#12
Eugenio Fazio, Valerio Bonacquisti, Marta Di Michele, Francesca Frasca, Angelo Chianese, Anna Maria Siani
Monitoring the air particulate concentration both outdoors and indoors is becoming a more relevant issue in the past few decades. An innovative, fully automatic, monitoring system called CleAir is presented. Such a system wants to go beyond the traditional technique (gravimetric analysis), allowing for a double monitoring approach: the traditional gravimetric analysis as well as the optical spectroscopic analysis of the scattering on the same filters in steady-state conditions. The experimental data are interpreted in terms of light percolation through highly scattering matter by means of the stretched exponential evolution...
September 11, 2017: Sensors
https://www.readbyqxmd.com/read/28888199/chlorambucil-labelled-with-the-phenosafranin-scaffold-as-a-new-chemotherapeutic-for-imaging-and-cancer-treatment
#13
Beata Miksa, Malgorzata Sierant, Ewa Skorupska, Adam Michalski, Slawomir Kazmierski, Urszula Steinke, Artur Rozanski, Pawel Uznanski
Here we report the first of the phenosafranin-chlorambucil conjugate as a new type of a chemotherapeutic agent suitable for dual detection methods (spectrophotometric and fluorescence) in imaging systems and cancer treatment. The synthetic cationic dye (3,7-diamino-5-phenylphenazinium chloride) is used as a fluorescent light-triggered scaffold that acts as a carrier for an anti-cancer drug. The chlorambucil was attached covalently via amide bonds to the bifunctional fluorophore, which facilitates tracking with visible light...
September 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28881331/breaking-down-barriers-the-evolution-of-cell-invasion
#14
REVIEW
Taylor N Medwig, David Q Matus
Cell invasion is a specialized cell behavior that likely co-evolved with the emergence of basement membranes in metazoans as a mechanism to break down the barriers that separate tissues. A variety of conserved and lineage-specific biological processes that occur during development and homeostasis rely on cell invasive behavior. Recent innovations in genome editing and live-cell imaging have shed some light on the programs that mediate acquisition of an invasive phenotype; however, comparative approaches among species are necessary to understand how this cell behavior evolved...
September 4, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28879640/creative-tensions-mutual-responsiveness-adapted-to-private-sector-research-and-development
#15
Matti Sonck, Lotte Asveld, Laurens Landeweerd, Patricia Osseweijer
The concept of mutual responsiveness is currently based on little empirical data in the literature of Responsible Research and Innovation (RRI). This paper explores RRI's idea of mutual responsiveness in the light of recent RRI case studies on private sector research and development (R&D). In RRI, responsible innovation is understood as a joint endeavour of innovators and societal stakeholders, who become mutually responsive to each other in defining the 'right impacts' of the innovation in society, and in steering the innovation towards realising those impacts...
September 7, 2017: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/28876611/construction-and-validation-of-low-cost-laparoscopic-simulator-using-android-smartphone-and-pop-cast-and-a-laptop
#16
A Vyas, G Goel
Minimal invasive surgery training requires a lot of practice and for this purpose innovative tools are needed to develop methods for practice and training skills outside the operating room. Commercially available devices are readily available but cost effectiveness and availability are major limiting factors in resource limited setting. We present an innovative and cost effective laparoscopic simulator which can be easily manufactured and used for practice of laparoscopic surgery. Using a free android application, such as IP webcam we can relay video to laptop without the use of any cables and uniquely we use the flash of a camera as the light source and a selfie stick for movement of the camera...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874504/proteome-analysis-of-hypoxic-glioblastoma-cells-reveals-sequential-metabolic-adaptation-nbsp-of-one-carbon-metabolic-pathways
#17
Kangling Zhang, Pei Xu, James L Sowers, Daniel F Machuca, Barsam Mirfattah, Jason Herring, Hui Tang, Yan Chen, Bing Tian, Allan R Brasier, Lawrence C Sowers
Rapidly proliferating tumors are exposed to a hypoxic microenvironment due to their density, high metabolic consumption, and interruptions in blood flow due to immature angiogenesis. Cellular responses to hypoxia promote highly malignant and metastatic behavior, as well as a chemotherapy-resistant state. In order to better understand the complex relationships between hypoxic adaptations and cancer progression, we studied the dynamic proteome responses of glioblastoma cells exposed to hypoxia via an innovative approach: quantification of newly synthesized proteins using heavy stable-isotope arginine labeling combined with accurate assessment of cell replication by quantification of the light/heavy arginine ratio of peptides in histone H4...
September 5, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28870157/ten-important-articles-on-noninvasive-ventilation-in-critically-ill-patients-and-insights-for-the-future-a-report-of-expert-opinions
#18
A Cortegiani, V Russotto, M Antonelli, E Azoulay, A Carlucci, G Conti, A Demoule, M Ferrer, N S Hill, S Jaber, P Navalesi, P Pelosi, R Scala, C Gregoretti
BACKGROUND: Noninvasive ventilation is used worldwide in many settings. Its effectiveness has been proven for common clinical conditions in critical care such as cardiogenic pulmonary edema and chronic obstructive pulmonary disease exacerbations. Since the first pioneering studies of noninvasive ventilation in critical care in the late 1980s, thousands of studies and articles have been published on this topic. Interestingly, some aspects remain controversial (e.g. its use in de-novo hypoxemic respiratory failure, role of sedation, self-induced lung injury)...
September 4, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28865936/effectiveness-of-a-shielded-ultraviolet-c-air-disinfection-system-in-an-inpatient-pharmacy-of-a-tertiary-care-children-s-hospital
#19
Don Guimera, Jean Trzil, Joy Joyner, Nicholas D Hysmith
Viable air particles pose a risk in areas where sterile preparations are compounded. This study investigated the efficacy of an innovative air purification technology that uses a shielded ultraviolet C light lamp to continuously purify the air in an inpatient pharmacy. Mean airborne fungal and bacterial colony forming units were obtained preinstallation and again in 6 months. A statistically significant decrease of 78% and 62% was observed for fungal and bacterial particles, respectively. This study demonstrates a potential role for this novel technology in decreasing the spread of airborne pathogens...
August 30, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28862473/from-phytoremediation-of-soil-contaminants-to-phytomanagement-of-ecosystem-services-in-metal-contaminated-sites
#20
Aritz Burges, Itziar Alkorta, Lur Epelde, Carlos Garbisu
Since the emergence of phytoremediation, much research has focused on its development for (i) the removal of metals from soil and/or (ii) the reduction of metal bioavailability, mobility and ecotoxicity in soil. Here, we review the lights and shades of the two main strategies (i.e., phytoextraction and phytostabilization) currently used for the phytoremediation of metal contaminated soils, irrespective of the level of such contamination. Both strategies face limitations to become successful at commercial scale and, then, often generate skepticism regarding their usefulness...
September 1, 2017: International Journal of Phytoremediation
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