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https://www.readbyqxmd.com/read/29156348/development-of-photoprotective-antiphototoxic-and-antiphotogenotoxic-formulations-of-ocular-drugs-with-fluoroquinolones
#1
Anna Zgadzaj, Joanna Kornacka, Anita Jastrzębska, Andrzej Parzonko, Sylwester Sommer, Grzegorz Nałęcz-Jawecki
The development of innovative solutions in photosafety of photolabile pharmaceutical products may help to reduce the adverse effects of these products, caused by light exposure. Providing new data in this area of study is particularly important in case of drugs applied topically on sensitive organs such as eyes. The main goal of this research is to investigate whether two potential excipients, namely: p-coumaric acid and benzophenone-4, affect the photodegradation, phototoxicity and photogenotoxicity of water solutions of four fluoroquinolones: ciprofloxacin, lomefloxacin, fleroxacin and clinafloxacin...
November 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29150271/xenohormesis-in-early-life-new-avenues-of-research-to-explore-anti-aging-strategies-through-the-maternal-diet
#2
Philippe de Medina
Aging is a progressive internal physiological deterioration of the organism, leading to the occurrence of age-related lethal diseases. It has become a major societal challenge to understand the processes that drive aging and to develop rational pharmacological agents and dietary approaches to fight against age-related deterioration and diseases. Interestingly, several lines of evidence highlight an influence of the developmental period on the risk of age-related diseases later in life. This field is known as the developmental origins of health and disease...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29147708/advanced-sensing-imaging-and-therapy-nanoplatforms-based-on-nd-3-doped-nanoparticle-composites-exhibiting-upconversion-induced-by-808-nm-near-infrared-light
#3
REVIEW
Ming-Hsien Chan, Ru-Shi Liu
Malignant tumors are currently the leading cause of death worldwide, followed by cardiovascular and cerebrovascular diseases. Although various methods, such as blood examination, tissue biopsy, and radiography, for tumor detection, exist, these techniques still require further refinement. Researchers have recently explored the use of novel adjuvant methods, specifically luminescence imaging detection, for the detection of tumors. The light-triggered approach is less invasive and induces fewer side effects than traditional detection methods...
November 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/29146935/quantitative-evaluation-of-nanosecond-pulsed-laser-induced-photomodification-of-plasmonic-gold-nanoparticles
#4
Andrew M Fales, William C Vogt, Joshua Pfefer, Ilko K Ilev
The rapid growth of gold nanoparticle applications in laser therapeutics and diagnostics has brought about the need for establishing innovative standardized test methods for evaluation of safety and performance of these technologies and related medical products. Furthermore, given the incomplete and inconsistent data on nanoparticle photomodification thresholds provided in the literature, further elucidation of processes that impact the safety and effectiveness of laser-nanoparticle combination products is warranted...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29145971/antimicrobial-blue-light-inactivation-of-pathogenic-microbes-state-of-the-art
#5
Yucheng Wang, Ying Wang, Yuguang Wang, Clinton K Murray, Michael R Hamblin, David C Hooper, Tianhong Dai
As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400-470nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light...
November 2017: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/29135993/bioequivalence-between-innovator-and-generic-tacrolimus-in-liver-and-kidney-transplant-recipients-a-randomized-crossover-clinical-trial
#6
Rita R Alloway, Alexander A Vinks, Tsuyoshi Fukuda, Tomoyuki Mizuno, Eileen C King, Yuanshu Zou, Wenlei Jiang, E Steve Woodle, Simon Tremblay, Jelena Klawitter, Jost Klawitter, Uwe Christians
BACKGROUND: Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients. Several professional transplant societies and publications have generated skepticism of the generic approval process. Three major areas of concern are that the pharmacokinetic properties of generic products and the innovator (that is, "brand") product in healthy volunteers may not reflect those in transplant recipients, bioequivalence between generic and innovator may not ensure bioequivalence between generics, and high-risk patients may have specific bioequivalence concerns...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29133243/peptides-as-a-strategy-against-biofilm-forming-microorganisms-structure-activity-relationship-perspectives
#7
REVIEW
Rafael Gomes Von Borowski, Alexandre José Macedo, Simone Cristina Baggio Gnoatto
Biofilm forming microorganisms substantially enhance their virulence and drug resistance causing and alternatives are need to combat this health problem. In this context, peptides are an exceptional strategy in drug design and pharmaceutical innovation due to their diverse chemical features, biological activity and biotechnological relevance. Therefore, this study proposes a comprehensive assessment of a wide range of peptides, targeting biofilms. It provides chemical and molecular information and a Structural Activity Relationship perspective in order to delineate minimal requirements for antibiofilm activity and contributing to the development of new antibiofilm agents...
November 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29132396/circulating-cell-free-dna-and-circulating-tumor-cells-the-liquid-biopsies-in-ovarian-cancer
#8
REVIEW
Xianliang Cheng, Lei Zhang, Yajuan Chen, Chen Qing
Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (cf-DNA) and circulating tumor cells (CTCs) emerging as "liquid biopsies". They represent non-invasive biomarkers and are viable, as they can be isolated from human plasma, serum and other body fluids. Molecular characterization of circulating tumor DNA (ct-DNA) and CTCs offer unique potentials to better understand the biology of metastasis and resistance to therapies...
November 13, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29131937/an-innovative-in-situ-ball-mill-for-x-ray-diffraction
#9
Voraksmy Ban, Yolanda Sadikin, Michael Lange, Nikolay A Tumanov, Yaroslav Filinchuk, Radovan Černý, Nicola P M Casati
The renewed interest of mechanochemistry as an eco-friendly synthetic route has inspired original methodologies to probe reactions, with the aim to rationalize unknown mechanisms. Recently, Friščić et al. [Nat Chem 2013, 5, 66-73] monitored the progress of milling reactions by synchrotron X-ray Powder Diffraction (XRPD). For the first time, it was possible to acquire directly information during a mechanochemical process. This new methodology is still in its early stages and its development will definitively transform the fundamental understanding of mechanochemistry...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29111745/self-assembled-3d-hierarchical-copper-hydroxyphosphate-modified-by-the-oxidation-of-copper-foil-as-a-recyclable-wide-wavelength-photocatalyst
#10
Wenling Jiao, Yifeng Cheng, Jie Zhang, Renchao Che
In this work, three-dimensional flower-like and petal-like copper hydroxyphosphate Cu5(OH)4(PO4)2 (CHP) based on the self-assembly of numerous nanosheets has been successfully fabricated on a copper foil by a mild one-pot wet-chemical method without ligand assistance. This research contributes to the development of the method to change the morphology of the CHP active material by varying the degree of substrate oxidation. The two different CHP architectures were used to photocatalytically degrade rhodamine 6G (Rh 6G) under solar light, which can absorb wide-range light wavelength from the UV to the near-infrared region...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29109447/opto-electric-investigation-for-si-organic-heterojunction-single-nanowire-solar-cells
#11
Zhenhai Yang, Zhaolang Liu, Jiang Sheng, Wei Guo, Yuheng Zeng, Pingqi Gao, Jichun Ye
Recently, silicon single nanowire solar cells (SNSCs) serving as the sustainable self-power sources have been integrated into optoelectronic nanodevices under the driver of technology and economy. However, conventional SNSC cannot provide the minimum energy consumption for the operation of nanodevices due to its low power conversion efficiency (PCE). Here, we propose an innovative approach to combine the n-type silicon nanowires (SiNWs) with p-type poly(3,4-ethylthiophene):poly(styrenesulfonate) (PEDOT:PSS) to form the p (+) n heterojunction, which shows superior opto-electric performances...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109396/electricity-generation-from-digitally-printed-cyanobacteria
#12
Marin Sawa, Andrea Fantuzzi, Paolo Bombelli, Christopher J Howe, Klaus Hellgardt, Peter J Nixon
Microbial biophotovoltaic cells exploit the ability of cyanobacteria and microalgae to convert light energy into electrical current using water as the source of electrons. Such bioelectrochemical systems have a clear advantage over more conventional microbial fuel cells which require the input of organic carbon for microbial growth. However, innovative approaches are needed to address scale-up issues associated with the fabrication of the inorganic (electrodes) and biological (microbe) parts of the biophotovoltaic device...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29105988/strategies-for-efficient-charge-separation-and-transfer-in-artificial-photosynthesis-of-solar-fuels
#13
Yuxing Xu, Ailong Li, Tingting Yao, Changtong Ma, Xianwen Zhang, Jafar Hussain Shah, Hongxian Han
Converting sunlight to solar fuels by artificial photosynthesis is an innovative science and technology for renewable energy. Light harvesting (LH), photogenerated charge separation and transfer (CST), and catalytic reactions (CR) are the three primary steps in the processes of solar energy to chemical energy (SE-CE) conversion. Among them, the CST is the key "energy pump and delivery" step in determining the overall solar energy conversion efficiency. Efficient CST is always the priority concern in designing and assembling artificial photosynthesis systems for solar fuels production...
November 4, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29104440/an-upgrade-pinning-block-a-mechanical-practical-aid-for-fast-labelling-of-the-insect-specimens
#14
Mohammad Hossein Ghafouri Moghaddam, Mostafa Ghafouri Moghaddam, Ehsan Rakhshani, Azizollah Mokhtari
A new mechanical innovation is described to deal with standard labelling of dried specimens on triangular cards and/or pinned specimens in personal and public collections. It works quickly, precisely, and easily and is very useful for maintaining label uniformity in collections. The tools accurately sets the position of labels in the shortest possible time. This tools has advantages including rapid processing, cost effectiveness, light weight, and high accuracy, compared to conventional methods. It is fully customisable, compact, and does not require specialist equipment to assemble...
2017: Biodiversity Data Journal
https://www.readbyqxmd.com/read/29102814/diverse-yeasts-for-diverse-fermented-beverages-and-foods
#15
REVIEW
Chris Todd Hittinger, James L Steele, David S Ryder
Yeasts play vital roles in food biotechnology, especially in fermented products. Yeasts are monoculture bioprocessing agents, are members of complex microbial communities, and are even consumed directly. Advances in genetic technologies, such as whole genome and environmental DNA sequencing, have shed light on the diverse yeasts used in both traditional and industrialized processes. The yeast Saccharomyces cerevisiae plays an outsized role in fermented beverage and food production, but new research has revealed a cornucopia of yeast biodiversity that includes dozens of species...
November 2, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29099743/local-positioning-system-using-flickering-infrared-leds
#16
Thibaut Raharijaona, Rodolphe Mawonou, Thanh Vu Nguyen, Fabien Colonnier, Marc Boyron, Julien Diperi, Stéphane Viollet
A minimalistic optical sensing device for the indoor localization is proposed to estimate the relative position between the sensor and active markers using amplitude modulated infrared light. The innovative insect-based sensor can measure azimuth and elevation angles with respect to two small and cheap active infrared light emitting diodes (LEDs) flickering at two different frequencies. In comparison to a previous lensless visual sensor that we proposed for proximal localization (less than 30 cm), we implemented: (i) a minimalistic sensor in terms of small size (10 cm 3 ), light weight (6 g) and low power consumption (0...
November 3, 2017: Sensors
https://www.readbyqxmd.com/read/29095657/redispersible-spray-dried-lipid-core-nanocapsules-intended-for-oral-delivery-the-influence-of-the-particle-number-on-redispersibility
#17
Diego Fontana de Andrade, Branko Vukosavljevic, Edilson Valmir Benvenutti, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres, Maike Windbergs, Ruy Carlos Ruver Beck
This study proposes a new approach to produce easily redispersible spray-dried lipid-core nanocapsules (LNC) intended for oral administration, evaluating the influence of the particle number density of the fed sample. The proposed approach to develop redispersible spray-dried LNC formulations intended for oral route is innovative, evidencing the needing of an optimization of the initial particle number density in the liquid suspension of nanocapsules. A mixture of maltodextrin and L-leucine (90:10 w/w) was used as drying adjuvant...
November 2, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29078583/technological-innovation-in-video-assisted-thoracic-surgery
#18
Mehmet Oğuzhan Özyurtkan, Erkan Kaba, Alper Toker
The popularity of video-assisted thoracic surgery (VATS) which increased worldwide due to the recent innovations in thoracic surgical technics, equipment, electronic devices that carry light and vision and high definition monitors. Uniportal VATS (UVATS) is disseminated widely, creating a drive to develop new techniques and instruments, including new graspers and special staplers with more angulation capacities. During the history of VATS, the classical 10 mm 0° or 30° rigid rod lens system, has been replaced by new thoracoscopes providing a variable angle technology and allowing 0° and 120° range of vision...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078580/magnetic-anchoring-guidance-system-in-video-assisted-thoracic-surgery
#19
REVIEW
Agnese Giaccone, Piergiorgio Solli, Luca Bertolaccini
The magnetic anchoring guidance system (MAGS) is one of the most promising technological innovations in minimally invasive surgery and consists in two magnetic elements matched through the abdominal or thoracic wall. The internal magnet can be inserted into the abdominal or chest cavity through a small single incision and then moved into position by manipulating the external component. In addition to a video camera system, the inner magnetic platform can house remotely controlled surgical tools thus reducing instruments fencing, a serious inconvenience of the uniportal access...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29076644/image-enhancement-variational-methods-for-enabling-strong-cost-reduction-in-oled-based-point-of-care-immunofluorescent-diagnostic-systems
#20
Damiana Lazzaro, Serena Morigi, Patrizia Melpignano, Elena Piccolomini, Luca Benini
OBJECTIVE: Immunofluorescence diagnostic systems cost is often dominated by high-sensitivity, low-noise CCD-based cameras which are used to acquire the fluorescence images. In this paper we investigate the use of low-cost CMOS sensors in a point-of-care immunofluorescence diagnostic application for the detection and discrimination of four different serotypes of the Dengue virus in a set of human samples. METHODS: A two-phase post-processing software pipeline is proposed which consists in a first image enhancement stage for resolution increasing and segmentation, and a second diagnosis stage for the computation of the output concentrations...
October 27, 2017: International Journal for Numerical Methods in Biomedical Engineering
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