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https://www.readbyqxmd.com/read/29775845/toward-innovative-combinational-immunotherapy-a-systems-biology-perspective
#1
REVIEW
Xue-Tao Li, Jin-Ji Yang, Yi-Long Wu, Jun Hou
The treatment of non-small-cell lung cancer (NSCLC) has advanced significantly in the last decades. Especially immune checkpoint inhibitors have shown inconceivable effect on enhancing host anti-tumor activity in NSCLC. However, the limitation of checkpoint blockade monotherapy seems unavoidable in most of the NSCLC patients and only ∼20% of them achieved response to monotherapy with immune checkpoint inhibitors. Thus combining immune checkpoint inhibitors with other agents with different action mechanisms holds a promise to revitalize NSCLC treatment, such as the combination of checkpoint inhibitors with angiogenesis inhibitors, or with chemotherapy, as well as the combination of two checkpoint inhibitors...
May 8, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29775159/bioinformatics-functional-analysis-of-let-7a-mir-34a-and-mir-199a-b-reveals-novel-insights-into-immune-system-pathways-and-cancer-hallmarks-for-hepatocellular-carcinoma
#2
Bangly Soliman, Ahmed Salem, Mohamed Ghazy, Nourhan Abu-Shahba, Mahmoud El Hefnawi
Let-7a, miR-34a, and miR-199 a/b have gained a great attention as master regulators for cellular processes. In particular, these three micro-RNAs act as potential onco-suppressors for hepatocellular carcinoma. Bioinformatics can reveal the functionality of these micro-RNAs through target prediction and functional annotation analysis. In the current study, in silico analysis using innovative servers (miRror Suite, DAVID, miRGator V3.0, GeneTrail) has demonstrated the combinatorial and the individual target genes of these micro-RNAs and further explored their roles in hepatocellular carcinoma progression...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29770299/regenerative-medicine-therapy-for-single-ventricle-congenital-heart-disease
#3
REVIEW
Chetan Ambastha, Gregory J Bittle, David Morales, Nathaniel Parchment, Progyaparamita Saha, Rachana Mishra, Sudhish Sharma, Alexander Vasilenko, Muthukumar Gunasekaran, Manal T Al-Suqi, Deqiang Li, Peixin Yang, Sunjay Kaushal
One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the ascending aorta. The underdeveloped LV is incapable of providing long-term systemic flow, and if left untreated, the condition is fatal. Current treatment for this condition consists of three consecutive staged palliative operations: the first is conducted within the first few weeks of birth, the second between 4 to 6 months, and the third and final surgery within the first 4 years...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29762138/theranostic-gold-magnetite-hybrid-nanoparticles-for-mri-guided-radiosensitization
#4
Devid Maniglio, Filippo Benetti, Luca Minati, Jorge Jovicich, Aldo Valentini, G Speranza, Claudio Migliaresi
The main limitation of drug-enhanced radiotherapy concerns the difficulty to evaluate the effectiveness of cancer targeting after drug administration hindering the standardization of therapies based on current radiosensitizing compounds. The challenge regards the development of systems able to combine imaging and radiotherapy enhancement in order to perform highly reliable cancer theragnosis. For these reasons, gold-magnetite hybrid nanoparticles are proposed as innovative theranostic nanotools for imaging-guided radiosensitization in cancer treatment...
May 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29758674/heterogeneous-update-mechanisms-in-evolutionary-games-mixing-innovative-and-imitative-dynamics
#5
Marco Antonio Amaral, Marco Alberto Javarone
Innovation and evolution are two processes of paramount relevance for social and biological systems. In general, the former allows the introduction of elements of novelty, while the latter is responsible for the motion of a system in its phase space. Often, these processes are strongly related, since an innovation can trigger the evolution, and the latter can provide the optimal conditions for the emergence of innovations. Both processes can be studied by using the framework of evolutionary game theory, where evolution constitutes an intrinsic mechanism...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29758538/preparation-and-characterization-of-iron-oxide-magnetic-nanoparticles-functionalized-by-nisin
#6
Ruta Gruskiene, Tatjana Krivorotova, Ramune Staneviciene, Dalius Ratautas, Elena Serviene, Jolanta Sereikaite
Nisin is a known bacteriocin approved as a food additive for food preservation. It exhibits a wide spectrum antimicrobial activity against Gram-positive bacteria. Iron oxide magnetic nanoparticles were synthesized and characterized by X-ray diffraction method. A main part of iron oxide nanoparticles was found to be maghemite though a small quantity of magnetite could also be present. Magnetic nanoparticles were stabilized by citric, ascorbic, gallic or glucuronic acid coating. Stable iron oxide magnetic nanoparticles were functionalized by nisin using a simple and low cost adsorption method...
May 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29755139/thermomechanical-properties-and-glass-dynamics-of-polymer-tethered-colloidal-particles-and-films
#7
Yu Cang, Anna N Reuss, Jaejun Lee, Jiajun Yan, Jianan Zhang, Elena Alonso-Redondo, Rebecca Sainidou, Pascal Rembert, Krzysztof Matyjaszewski, Michael R Bockstaller, George Fytas
Polymer-tethered colloidal particles (aka "particle brush materials") have attracted interest as a platform for innovative material technologies and as a model system to elucidate glass formation in complex structured media. In this contribution, Brillouin light scattering is used to sequentially evaluate the role of brush architecture on the dynamical properties of brush particles in both the individual and assembled (film) state. In the former state, the analysis reveals that brush-brush interactions as well as global chain relaxation sensitively depend on grafting density; i...
November 14, 2017: Macromolecules
https://www.readbyqxmd.com/read/29749932/cardiac-optogenetics-2018
#8
REVIEW
Patrick M Boyle, Thomas V Karathanos, Natalia A Trayanova
Cardiac optogenetics is an emergent research area involving the delivery of light-sensitive proteins (opsins) to excitable heart tissue to enable optical modulation of cardiac electrical function. Optogenetic stimulation has many noteworthy advantages over conventional electrical methods, including selective electrophysiological modulation in specifically targeted cell subpopulations, high-resolution spatiotemporal control via patterned illumination, and use of different opsins to elicit inward or outward transmembrane current...
February 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29748798/an-innovative-approach-to-attached-cultivation-of-chlorella-vulgaris-using-different-materials
#9
Negar Jafari, Razieh Shafiee Alavijeh, Ali Abdolahnejad, Hossein Farrokhzadeh, Mohammad Mehdi Amin, Afshin Ebrahimi
This article investigates the innovative attached cultivation of Chlorella vulgaris (C. vulgaris) using different materials as an alternative to high capital techniques of harvesting such as centrifugation, flocculation, and filtration. A simple attached algal cultivation system was proposed that was equipped by 10 submerged supporting materials which can harvest algal cells, efficiently. The effect of operational parameters such as light intensity, the rate of aeration, and auto-harvesting time was investigated...
May 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29748417/natural-experiment-examining-the-longitudinal-association-between-change-in-residential-segregation-and-youth-cardiovascular-health-across-race-ethnicity-and-gender-in-the-usa
#10
REVIEW
Emily M D'Agostino, Hersila H Patel, Zafar Ahmed, Eric Hansen, M Sunil Mathew, Maria I Nardi, Sarah E Messiah
BACKGROUND: Identifying how racial/ethnic residential segregation and mobility may impact health can guide innovative strategies for reducing youth disparities. METHODS: This natural experiment examined the association between change in residential segregation and cardiovascular health outcomes across race/ethnicity and gender for youth (n=2250, mean age 9.1 years, 54% male; 51% Hispanic, 49% non-Hispanic black (NHB); 49% high area poverty) attending a multisite park-based afterschool fitness programme in Florida, USA...
May 10, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29743596/genome-wide-profiling-of-micrornas-reveals-novel-insights-into-the-interactions-between-h9n2-avian-influenza-virus-and-avian-dendritic-cells
#11
Jian Lin, Jing Xia, Tian Zhang, Keyun Zhang, Qian Yang
The antigen-presenting ability of dendritic cells (DCs) plays an important and irreplaceable role in recognising and clearing viruses. Antiviral responses must rapidly defend against infection while minimising inflammatory damage, but the mechanisms that regulate the magnitude of response within an infected cell are not well understood. MicroRNAs (microRNAs), small non-coding RNAs, can regulate mouse or avian DCs to inhibit the infection and replication of avian influenza virus (AIV). Here, we performed a global analysis to understand how avian DCs respond to H9N2 AIV and provide a potential mechanism to explain how avian microRNAs can defend against H9N2 AIV replication...
May 10, 2018: Oncogene
https://www.readbyqxmd.com/read/29743014/comprehensive-analyses-of-the-bes1-gene-family-in-brassica-napus-and-examination-of-their-evolutionary-pattern-in-representative-species
#12
Xiaoming Song, Xiao Ma, Chunjin Li, Jingjing Hu, Qihang Yang, Tong Wang, Li Wang, Jinpeng Wang, Di Guo, Weina Ge, Zhenyi Wang, Miaomiao Li, Qiumei Wang, Tianzeng Ren, Shuyan Feng, Lixia Wang, Weimeng Zhang, Xiyin Wang
BACKGROUND: The BES1 gene family, an important class of plant-specific transcription factors, play key roles in the BR signal pathway in plants, regulating various development processes. Until now, there has been no comprehensive analysis of the BES1 gene family in Brassica napus, and a cross-genome exploration of their origin, copy number changes, and functional innovation in plants was also not available. RESULTS: We identified 28 BES1 genes in B. napus from its two subgenomes (AA and CC)...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29737828/light-activated-ros-responsive-nanoplatform-co-delivering-apatinib-and-doxorubicin-for-enhanced-chemo-photodynamic-therapy-of-multidrug-resistant-tumors
#13
Xiao Wei, Lingqiao Liu, Xing Guo, Yi Wang, Jingya Zhao, Shaobing Zhou
Cancer chemotherapy faces the problem of the multidrug resistance (MDR) of tumor cells, which is a puzzling issue that leads to treatment failure. To address it, an innovative approach is proposed to construct a light-activated reactive oxygen species (ROS)-responsive nanoplatform based on a protoporphyrin (PpIX)-conjugated and dual chemotherapeutics-loaded polymer micelle. This system combines chemotherapy and photodynamic therapy (PDT) to defeat the MDR of tumors. Such an intelligent nanocarrier can prolong the blood circulation due to the negatively charged polysaccharide component of chondroitin sulfate (CS) and subsequently being selectively internalized by DOX-resistant human breast cancer MCF-7 cells (MCF-7/ADR)...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29735889/saturated-imaging-for-inspecting-transparent-aesthetic-defects-in-a-polymeric-polarizer-with-black-and-white-stripes
#14
Cilong Yu, Peibing Chen, Xiaopin Zhong, Xizhou Pan, Yuanlong Deng
Machine vision systems have been widely used in industrial production lines because of their automation and contactless inspection mode. In polymeric polarizers, extremely slight transparent aesthetic defects are difficult to detect and characterize through conventional illumination. To inspect such defects rapidly and accurately, a saturated imaging technique was proposed, which innovatively uses the characteristics of saturated light in imaging by adjusting the light intensity, exposure time, and camera gain...
May 7, 2018: Materials
https://www.readbyqxmd.com/read/29730310/analysis-and-identification-of-elongated-mineral-particles-in-road-coated-aggregates
#15
Erell Leocat, Christophe Rielland, Aurélien Urvoy, Patrice Letessier
The issue of Elongated Mineral Particles (EMP) in building materials has been revealed during roadworks in 2013 in France. In fact, road coating aggregates are made of specific rock gravels that can contain Naturally Occurring Asbestos (NOA), which is mainly actinolite. The legislation refers to six regulatory asbestos, that consist in asbestiform habitus of the six minerals. The current technical standard is not adapted for analyzing natural material, as it cannot distinguish the asbestiform fibers and the cleavage fragments fibers...
May 3, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29730283/photodynamic-therapy-as-an-alternative-to-antibiotic-therapy-for-the-treatment-of-infected-leg-ulcers
#16
REVIEW
Aleksandra Kawczyk-Krupka, Barbara Pucelik, Anna Międzybrodzka, Aleksander Sieroń, Janusz M Dąbrowski
Infected leg ulcers are painful, debilitating and immensely reducing patient's quality of life, therefore they are becoming a more and more significant clinical and socioeconomic problems nowadays. Increasing resistance to antibiotics, drugs and therapies is one of the most urgent challenge in medicine worldwide and requires searching for a new, innovative and more efficient medical strategies. One of the opportunities for the cure of leg ulcers is photodynamic inactivation (PDI), that has been widely used in the treatment of various bacterial, fungal and viral infections...
May 3, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29727791/facile-synthesis-of-highly-reactive-and-stable-fe-doped-g-c-3-n-4-composites-for-peroxymonosulfate-activation-a-novel-nonradical-oxidation-process
#17
Yong Feng, Changzhong Liao, Lingjun Kong, Deli Wu, Yiming Liu, Po-Heng Lee, Kaimin Shih
Ferrous ions (Fe2+ ) are environmentally friendly materials but show extremely inefficient persulfate activation. Polymeric graphitic carbon nitride (g-C3 N4 ) has recently shown potential to activate persulfates, but the process requires intense light irradiation. To overcome these drawbacks, we designed an innovative heterogeneous iron catalyst by doping Fe into g-C3 N4 (Fe-g-C3 N4 ) and used it to activate peroxymonosulfate (PMS) for degradation of pollutant phenol. The catalysts synthesized were fully characterized with various techniques, such as X-ray diffraction, Mössbauer spectroscopy, and X-ray photoelectron spectroscopy...
April 25, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29726415/going-mobile-an-empirical-model-for-explaining-successful-information-logistics-in-ward-rounds
#18
Moritz Esdar, Jan-David Liebe, Birgit Babitsch, Ursula Hübner
BACKGROUND: Medical ward rounds are critical focal points of inpatient care that call for uniquely flexible solutions to provide clinical information at the bedside. While this fact is undoubted, adoption rates of mobile IT solutions remain rather low. OBJECTIVES: Our goal was to investigate if and how mobile IT solutions influence successful information provision at the bedside, i.e. clinical information logistics, as well as to shed light at socio-organizational factors that facilitate adoption rates from a user-centered perspective...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29719963/point-of-care-tests-verifynow-p2y12-and-innovance-pfa-p2y-compared-to-light-transmittance-aggregometry-after-fibrinolysis
#19
Vincent Roule, Pierre Ardouin, Yohan Repessé, Agnès Le Querrec, Katrien Blanchart, Adrien Lemaitre, Rémi Sabatier, Annie Borel-Derlon, Farzin Beygui
Detection of high on-treatment platelet reactivity (HPR) by point-of-care tests has not been validated after successful fibrinolysis for ST-elevation myocardial infarction. We assessed the validity of the point-of-care VerifyNow P2Y12 (VN) and INNOVANCE PFA P2Y (PFA) tests on HPR compared to light transmittance aggregometry (LTA) in these patients. The HPR was identified in 10 (34.5%) patients, 15 (51.7%) patients, and 14 (50%) patients using LTA, VN, and PFA, respectively. Discrepancies were observed between the tests despite significant correlations between platelet reactivity measures by LTA and VN ( r = 0...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29718307/ecological-expansion-and-extinction-in-the-late-ediacaran-weighing-the-evidence-for-environmental-and-biotic-drivers
#20
Lidya G Tarhan, Mary L Droser, Devon B Cole, James G Gehling
The Ediacara Biota, Earth's earliest communities of complex, macroscopic, multicellular organisms, appeared during the late Ediacaran Period, just prior to the Cambrian Explosion. Ediacara fossil assemblages consist of exceptionally preserved soft-bodied forms of enigmatic morphology and affinity which nonetheless represent a critical stepping-stone in the evolution of complex animal ecosystems. The Ediacara Biota has historically been divided into three successive Assemblages-the Avalon, the White Sea and the Nama...
April 27, 2018: Integrative and Comparative Biology
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