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Isolde G Rojas, Maria L Spencer, Paulina A Zapata, Alejandra Martínez, Rosario Alarcón, Francisco J Marchesani, Mine Tezal
BACKGROUND: Differences in immune profile between actinic cheilitis (AC), a precursor of lip squamous cell carcinoma, and normal lip vermillion (NL) have not been elucidated. OBJECTIVES: To compare density, distribution, and ratios of CD8+ and FoxP3+ cells between AC and NL and assess their associations with clinicopathologic variables. METHODS: Samples of AC and NL obtained between 2001 and 2013 at the College of Dentistry of the University of Concepcion, Chile, were retrospectively analyzed for immunohistochemical detection of CD8+ and FoxP3+ cells...
October 25, 2016: International Journal of Dermatology
Sarah F M Pilati, Bianca C Bianco, Daniella S C Vieira, Filipe Modolo
OBJECTIVE: This study aimed to determine the histopathological findings in actinic cheilitis (AC) and lip squamous cell carcinomas (LSCC) diagnosed at Federal University of Santa Catarina in order to attempt to predict the evolution from AC to LSCC based on the comparison of two dysplasia classification systems. METHODS: Histopathological features were evaluated according to the World Health Organization classification of dysplasia and binary system of classification...
October 19, 2016: Oral Diseases
Gadavalli Vera Venkata Satyakiran, Radhika Manoj Bavle, Glory Alexander, Saritha Rao, Reshma Venugopal, Sreelatha S Hosthor
INTRODUCTION: Human immunodeficiency virus (HIV) infection gradually destroys the body's immune system, which makes it harder for the body to fight infections. HIV infection causes a quantitative and qualitative depletion of CD4 lymphocyte count, which increases the risk of opportunistic infections. Thus, CD4 count is one of the key factors in determining both the urgency of highly active antiretroviral therapy (HAART) initiation and the need of prophylaxis for opportunistic infections...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Ling Gu, Yan Huang, Chong Jian Fu, Zhao Ling Wang, Ying Liu, Guo Xiong Zhu
No abstract text is available yet for this article.
September 14, 2016: European Journal of Dermatology: EJD
Paola Lucia Minciullo, Giovanni Paolino, Maddalena Vacca, Sebastiano Gangemi, Eustachio Nettis
The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the oral mucosa to irritant agents and allergens due to anatomical and physiological factors. The spectrum of signs and symptoms of oral contact allergies (OCA) is broad and a large number of condition can be the clinical expression of OCA such as allergic contact stomatitis, allergic contact cheilitis, geographic tongue, oral lichenoid reactions, burning mouth syndrome...
2016: Clinical and Molecular Allergy: CMA
I Schwarz, D Bokanovic, W Aberer
The oral allergy syndrome is one of the most common form of food allergy and manifests as contact urticaria of the oral mucosa after consumption of cross reacting foods. Whereas allergic contact stomatitis often occurs due to dental materials, allergic contact cheilitis is usually a reaction due to topical therapeutics like herpes ointments or lip care products. As late type reactions are more frequent than immediate type reactions in the anogenital mucosa, contact dermatitis in this area should be identified via epicutaneous testing...
October 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Dmitry José de Santana Sarmento, Gustavo Pina Godoy, Márcia Cristina da Costa Miguel, Éricka Janine Dantas da Silveira
BACKGROUND: The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data. OBJECTIVE: To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics. METHODS: We analyzed 40 cases. Histological and immunohistochemical analyses were performed. The following clinical variables were evaluated: gender, age range, ethnicity, clinical aspect and occupational sunlight exposure...
July 2016: Anais Brasileiros de Dermatologia
Duriye Deniz Demirseren, Fadime Kilinc, Selma Emre, Mesut Akyol, Ahmet Metin, Akin Aktas
BACKGROUND: The purpose of our study is to find out in which weeks and in which cumulative doses the side effects emerge and to study whether or not there is a significant variance between the observed period and doses of the emergent side effects of the patients taking the daily doses of below and above 0.5 mg/kg. METHODS: Patients were started treatment with doses of 0.25-1 mg/kg isotretinoin, and a form was given to the patients to mark which probable side effects occurred in which weeks and called for weekly follow-up for the first 2 months...
September 15, 2016: Journal of Dermatological Treatment
A Leclercq, E Cinotti, B Labeille, B Cribier, A C Biron, C Vermersch, J Montlouis, F Cambazard, J L Perrot
PATIENTS AND METHODS: Herein we report the case of an 18-year-old pregnant patient presenting with plantar and ano-genital lesions of syphilis, pharyngitis, erythematosus and scalynasolabial intertrigo and angular cheilitis. REFLECTANCE CONFOCAL MICROSCOPY: In vivo reflectance confocal microscopy examination (Vivascope 3000(®); Caliber Inc, Rochester, NY, USA, distributed in France by Mavig, Munich) of ano-genital lesions enabled us to identify hyper-reflective elongated rods in the papillary dermis suggesting spirochetes...
August 23, 2016: Annales de Dermatologie et de Vénéréologie
Ana Flávia Schueler de Assumpção Leite, Vagner Gonçalves Bernardo, Luisa Aguirre Buexm, Eliene Carvalho da Fonseca, Licínio Esmeraldo da Silva, Danielle Resende Camisasca Barroso, Simone de Queiroz Chaves Lourenço
OBJECTIVE: This study aimed to evaluate apoptosis by assessing cleaved caspase-3 immunoexpression in hyperplastic, potentially malignant disorder (PMD), and malignant tumors in intraoral and lower lip sites. MATERIAL AND METHODS: A retrospective study using paraffin blocks with tissues from patients with inflammatory fibrous hyperplasia (IFH), actinic cheilitis, oral leukoplakia, lower lip and intraoral squamous cell carcinoma (SCC) was performed. The tissues were evaluated by immunohistochemical analysis with anti-cleaved caspase-3 antibody...
July 2016: Journal of Applied Oral Science: Revista FOB
Elżbieta Maria Paszyńska, Agnieszka Słopień, Agata Osińska, Monika Dmitrzak-Węglarz, Andrzej Rajewski, Anna Surdacka
INTRODUCTION: The most important endogenous causes of erosion are eating disorders, gastro-oesophageal reflux (GERD), alcoholism and syndromes involving lowered saliva secretion. AIM: The aim of this work is to study a patient with symptoms of somatoform autonomic dysfunction, in which significant erosive loss occurred through chemical influence of gastric acid on oral cavity. METHODS: Seventeen years old girl was sent to Department of Child and Adolescent Psychiatry due to persistent nausea and vomiting, which occurred over a period of about 10 months...
2016: Psychiatria Polska
Ayomi Dilhari, Manjula M Weerasekera, Anusha Siriwardhana, Oshanthi Maheshika, Chinthika Gunasekara, Sunil Karunathilaka, Ajith Nagahawatte, Neluka Fernando
OBJECTIVES: The study aimed to determine the proportion, known risk factors and etiology for Candida infection in leukoplakia lesions among patients with oral leukoplakia attending the Oral and Maxillofacial Clinic at a Tertiary Care Hospital in Sri Lanka. MATERIALS AND METHODS: Eighty clinically suspected oral leukoplakia patients were included. Two oral swabs each, from leukoplakia patients: one swab from the lesion and the other one from the contralateral unaffected corresponding area (as a control) were collected...
October 2016: Acta Odontologica Scandinavica
Evangelia Tzika, Isabelle Masouyé, Michael Mühlstädt, Emmanuel Laffitte
We present the case of a healthy 76-year-old man with a whitish, hyperkeratotic lesion of the lower lip diagnosed as actinic cheilitis (AC) previously treated with classic red light photodynamic therapy 5 years ago. Initial treatment with 5% imiquimod cream - also with intensified application - failed. After 2 cycles thrice daily, consecutive applications of 150 μg/g ingenol mebutate gel at 3 weeks' interval, the lesions cleared completely. Surprisingly, no pustular or crusting reaction or other side effect occurred contrary to expectation...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
Yasuyuki Yamaguchi, Wataru Nishie, Takamasa Ito, Hiroshi Shimizu
No abstract text is available yet for this article.
August 8, 2016: European Journal of Dermatology: EJD
Luis Felipe das Chagas E Silva, Thiago Martini Pereira, Taciana Depra Magrini, Ana Sueli Rodrigues Cavalcante, Herculano da Silva Martinho, Janete Dias Almeida
: Actinic cheilitis (AC) is considered a potentially malignant disorder of the lip. Biomolecular markers study is important to understand malignant transformation into squamous cell carcinoma. Fourier transform infra red (FT-IR) spectroscopy was used to analyze AC in this study. OBJECTIVES: The aim of the study was to evaluate if FT-IR spectral regions of nucleic acids and collagen can help in early diagnosis of malignant transformation. METHODS: Tissues biopsies of 14 patients diagnosed with AC and 14 normal tissues were obtained...
August 1, 2016: Photodiagnosis and Photodynamic Therapy
Marius Rademaker
BACKGROUND/OBJECTIVES: Rosacea is a chronic inflammatory disorder that affects up to 10% of the population. Standard treatments include topical azelaic acid and metronidazole or systemic tetracyclines. Isotretinoin has generally been restricted to severe disease, often at a dose of 0.5-1.0 mg/kg/day. METHOD: Retrospective review of open-label isotretinoin (initial dose 20 mg/day, with dose adjustments according to response), in patients with mild to moderate papulopustular rosacea...
July 20, 2016: Australasian Journal of Dermatology
Miranda Muhvić-Urek, Marija Tomac-Stojmenović, Brankica Mijandrušić-Sinčić
The incidence of inflammatory bowel diseases (IBD) - Crohn's disease (CD) and ulcerative colitis (UC) - has been increasing on a global scale, and progressively, more gastroenterologists will be included in the diagnosis and treatment of IBD. Although IBD primarily affects the intestinal tract, extraintestinal manifestations of the disease are often apparent, including in the oral cavity, especially in CD. Specific oral manifestations in patients with CD are as follows: indurate mucosal tags, cobblestoning and mucogingivitis, deep linear ulcerations and lip swelling with vertical fissures...
July 7, 2016: World Journal of Gastroenterology: WJG
Natália G Barbosa, Lélia B Souza, Cassiano F W Nonaka, Ericka J D Silveira
BACKGROUND: Actinic cheilitis is a potentially malignant condition caused mainly by chronic sun exposure. Here we aim to evaluate the role of hypoxia, angiogenesis, and lymphatic density in the clinical and morphological progression of a series of cases of actinic cheilitis. MATERIALS AND METHODS: Immunohistochemistry was used to evaluate positivity to hypoxia-inducible factor (HIF)-1α, vascular endothelial growth factor (VEGF)-C, and D2-40 in 40 cases of actinic cheilitis of the lower lip...
July 15, 2016: International Journal of Dermatology
Pieter Bourgeois, An Goossens
No abstract text is available yet for this article.
August 2016: Contact Dermatitis
Silvia Tortorici, Salvatore Corrao, Giuseppe Natoli, Paolo Difalco
BACKGROUNG: The aim of the present study was to determine the prevalence of oral mucosal non-malignant lesions in the Sicilian population. In addition, we evaluated the association between each oral lesion and its risk factors. METHODS: This study analyzed a total of 2539 consecutive patients, attending the Department of Surgical, Oncological and Stomatological Disciplines of Palermo University, who were examined for the presence of various oral lesions during the period from January 2012 and February 2015...
August 2016: Minerva Stomatologica
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