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https://www.readbyqxmd.com/read/28346894/the-romberg-ratio-in-people-with-multiple-sclerosis
#1
Alon Kalron
Postural control relies on the integration of inputs from the visual, somatosensory and vestibular systems which are frequently impaired in people with Multiple Sclerosis (PwMS). In this situation, examining the Romberg ratio can be useful. This parameter can be interpreted as a gross indicator of a vestibular and proprioceptive contribution to postural control. Therefore, the primary objective of the current study was to examine whether the Romberg ratio differs between MS fallers, non-fallers and neurological disability levels...
March 14, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28346588/association-between-childhood-onset-epilepsy-and-amyloid-burden-5-decades-later
#2
Juho Joutsa, Juha O Rinne, Bruce Hermann, Mira Karrasch, Anu Anttinen, Shlomo Shinnar, Matti Sillanpää
Importance: The effect of childhood epilepsy on later-life cognitive and brain health is an unclear and little-explored issue. Objective: To determine whether adults with a history of childhood-onset epilepsy exhibit increased brain amyloid accumulation, possibly predisposing to accelerated cognitive impairment or even frank cognitive disorders in later life. Design, Setting, and Participants: Forty-one adults from a population-based cohort of individuals with childhood-onset epilepsy in southwestern Finland, together with 46 matched population-based controls, underwent amyloid ligand carbon 11-labeled Pittsburgh Compound B (PiB) positron emission tomography after long-term prospective follow-up...
March 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28345570/appraising-the-spectrum-of-firework-trauma-and-the-related-laws-during-diwali-in-north-india
#3
Ramesh Venkatesh, Prachi Gurav, Shailja Tibrewal, Manisha Agarwal, Suneeta Dubey, Umang Mathur, Suma Ganesh, Sima Das
PURPOSE: To evaluate the epidemiological characteristics and outcomes of ocular injuries resulting from the use of firecrackers during the Diwali festival in all age groups. MATERIALS AND METHODS: A single-center, retrospective, hospital-based case series presenting with ocular trauma consequent to fireworks usage in a tertiary eye care center in North India during the 5 days of Diwali festival from 2011 to 2015 was conducted. RESULTS: A total of 53 eyes of 45 patients were included in the study, out of which the vast majority (39/87%) were males...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345563/chlamydial-eye-infections-current-perspectives
#4
Gita Satpathy, Himanshu Sekhar Behera, Nishat Hussain Ahmed
Chlamydia trachomatis, an obligate intraocular bacteria causing trachoma, adult and neonatal inclusion conjunctivitis, was the leading cause of blindness in the last century worldwide. Improvement in socioeconomic and living conditions, availability of antibiotics, and introduction of National Trachoma Control Programmes reduced the prevalence in developed countries, but it persisted in resource-poor settings of Africa and Asia, including India. In 2016, as per the WHO report, trachoma is restricted to 42 countries, causing blindness/visual impairment in ~1...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345562/definition-of-blindness-under-national-programme-for-control-of-blindness-do-we-need-to-revise-it
#5
Praveen Vashist, Suraj Singh Senjam, Vivek Gupta, Noopur Gupta, Atul Kumar
A review appropriateness of the current definition of blindness under National Programme for Control of Blindness (NPCB), Government of India. Online search of peer-reviewed scientific published literature and guidelines using PubMed, the World Health Organization (WHO) IRIS, and Google Scholar with keywords, namely blindness and visual impairment, along with offline examination of reports of national and international organizations, as well as their cross-references was done until December 2016, to identify relevant documents on the definition of blindness...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345517/ptosis-and-vertical-diplopia-after-ligation-of-ethmoidal-arteries
#6
A Kahn, L Laccourreye, H D Fournier, C Brecheteau
The treatment of epistaxis is well codified, ligation of the ethmoidal arteries being the last resort. We report the case of a 25-year-old pregnant patient, who has had a ligation of the anterior and posterior ethmoidal arteries after a persistent epistaxis. Postoperatively, she presented a complete ptosis and an impaired eye elevation without any visual acuity disorders, evoking a lesion of the upper branch of the common oculomotor nerve (third cranial nerve). The patient totally recovered after 3 months...
February 21, 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28343958/simultanagnosia-does-not-affect-processes-of-auditory-gestalt-perception
#7
Johannes Rennig, Anna Lena Bleyer, Hans-Otto Karnath
Simultanagnosia is a neuropsychological deficit of higher visual processes caused by temporo-parietal brain damage. It is characterized by a specific failure of recognition of a global visual Gestalt, like a visual scene or complex objects, consisting of local elements. In this study we investigated to what extend this deficit should be understood as a deficit related to specifically the visual domain or whether it should be seen as defective Gestalt processing per se. To examine if simultanagnosia occurs across sensory domains, we designed several auditory experiments sharing typical characteristics of visual tasks that are known to be particularly demanding for patients suffering from simultanagnosia...
March 23, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28343279/the-independent-influences-of-heat-strain-and-dehydration-upon-cognition
#8
Anne M J van den Heuvel, Benjamin J Haberley, David J R Hoyle, Nigel A S Taylor, Rodney J Croft
PURPOSE: Many researchers have addressed the potential effects of hyperthermia and dehydration on cognition, often revealing contradictory outcomes. A possible reason for this inconsistency is that experiments may have been inadequately designed for such effects. In this study, the impact of hyperthermia, dehydration and their combination on cognition were evaluated in eight young males, after accounting for a range of experimental limitations. METHODS: Passive heating and thermal clamping at two mean body temperatures (36...
March 25, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28342918/evidence-of-the-impact-of-visuo-spatial-processing-on-magnitude-representation-in-22q11-2-microdeletion-syndrome
#9
Lucie Attout, Marie-Pascale Noël, Line Vossius, Laurence Rousselle
The influence of visuo-spatial skills on numerical magnitude processing is the subject of a long-standing debate. As most of the numerical and non-numerical magnitude abilities underpinning mathematical development are visual by nature, they are often assessed in the visual modality, thereby confusing visuo-spatial and numerical processing. In order to assess the influence of visuo-spatial processing on numerical magnitude representation, we examined magnitude processing in patients with 22q11.2 deletion syndrome (22q11DS), a genetic condition characterized by a cognitive profile with a relative weakness in visuo-spatial abilities but with preserved verbal abilities...
March 22, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28342330/probing-the-magnocellular-and-parvocellular-visual-pathways-in-facial-emotion-perception-in-schizophrenia
#10
Carol Jahshan, Maor Wolf, Yinnon Karbi, Eyal Shamir, Yuri Rassovsky
Schizophrenia patients have well-established deficits in facial emotion perception, which contribute to their poor social functioning. A number of studies have related these deficits to a differential dysfunction in the magnocellular (M) versus parvocellular (P) visual pathway. We assessed 35 schizophrenia patients and 35 healthy individuals on an emotion identification task, in which facial stimuli were either unaltered (broad spatial frequency, BSF) or manipulated to contain only high (HSF) or low (LSF) spatial frequencies, thereby respectively biasing the visual system toward the P- or M- pathways...
March 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28341991/altered-interhemispheric-functional-connectivity-in-patients-with-anisometropic-and-strabismic-amblyopia-a-resting-state-fmri-study
#11
Minglong Liang, Bing Xie, Hong Yang, Xuntao Yin, Hao Wang, Longhua Yu, Sheng He, Jian Wang
PURPOSE: Altered brain functional connectivity has been reported in patients with amblyopia by recent neuroimaging studies. However, relatively little is known about the alterations in interhemispheric functional connectivity in amblyopia. The present study aimed to investigate the functional connectivity patterns between homotopic regions across hemispheres in patients with anisometropic and strabismic amblyopia under resting state. METHODS: Nineteen monocular anisometropic amblyopia (AA), 18 strabismic amblyopia (SA), and 20 normal-sight controls (NC) were enrolled in this study...
March 24, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28341616/cloudy-with-a-chance-of-pain-engagement-and-subsequent-attrition-of-daily-data-entry-in-a-smartphone-pilot-study-tracking-weather-disease-severity-and-physical-activity-in-patients-with-rheumatoid-arthritis
#12
Samuel Reade, Karen Spencer, Jamie C Sergeant, Matthew Sperrin, David M Schultz, John Ainsworth, Rashmi Lakshminarayana, Bruce Hellman, Ben James, John McBeth, Caroline Sanders, William G Dixon
BACKGROUND: The increasing ownership of smartphones provides major opportunities for epidemiological research through self-reported and passively collected data. OBJECTIVE: This pilot study aimed to codesign a smartphone app to assess associations between weather and joint pain in patients with rheumatoid arthritis (RA) and to study the success of daily self-reported data entry over a 60-day period and the enablers of and barriers to data collection. METHODS: A patient and public involvement group (n=5) and 2 focus groups of patients with RA (n=9) supported the codesign of the app collecting self-reported symptoms...
March 24, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28341475/genotypic-and-phenotypic-characteristics-of-crb1-associated-retinal-dystrophies-a-long-term-follow-up-study
#13
Mays Talib, Mary J van Schooneveld, Maria M van Genderen, Jan Wijnholds, Ralph J Florijn, Jacoline B Ten Brink, Nicoline E Schalij-Delfos, Gislin Dagnelie, Frans P M Cremers, Ron Wolterbeek, Marta Fiocco, Alberta A Thiadens, Carel B Hoyng, Caroline C Klaver, Arthur A Bergen, Camiel J F Boon
PURPOSE: To describe the phenotype, long-term clinical course, clinical variability, and genotype of patients with CRB1-associated retinal dystrophies. DESIGN: Retrospective cohort study. PARTICIPANTS: Fifty-five patients with CRB1-associated retinal dystrophies from 16 families. METHODS: A medical record review of 55 patients for age at onset, medical history, initial symptoms, best-corrected visual acuity, ophthalmoscopy, fundus photography, full-field electroretinography (ffERG), Goldmann visual fields (VFs), and spectral-domain optical coherence tomography...
March 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28340167/factors-influencing-cognitive-impairment-in-neuropathic-and-musculoskeletal-pain-and-fibromyalgia
#14
Begoña Ojeda, María Dueñas, Alejandro Salazar, Juan Antonio Mico, Luis Miguel Torres, Inmaculada Failde
Objective.:  To assess cognitive performance of chronic pain (CP) patients diagnosed with three types of pain-neuropathic pain (NP), musculoskeletal (MSK), and fibromyalgia (FM)-and to analyze the factors influencing cognitive difficulties in each group. Methods.:  Two hundred fifty-four CP patients-104 NP, 99 MSK, 51 FM-and 72 pain-free subjects were included in the study. The "Test Your Memory" (TYM) scale was used to assess cognitive performance. Pain intensity was measured by means of the visual analog scale (VAS); the Hospital Anxiety and Depression scale was used to assess mental status, and the Medical Outcome Study (MOS) sleep scale to assess sleep quality...
March 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339980/pushing-the-limits-establishing-an-ultra-low-framerate-and-antiscatter-grid-less-radiation-protocol-for-left-atrial-ablations
#15
Philipp Attanasio, Tobias Schreiber, Burkert Pieske, Florian Blaschke, Leif-Hendrik Boldt, Wilhelm Haverkamp, Martin Huemer
Aims: Despite the use of 3D mapping systems and new developments of non-fluoroscopic options, most centres still rely at least in part on fluoroscopy for catheter visualization during catheter ablations. The purpose of this study was to assess the feasibility of using an ultra-low frame rate and antiscatter grid-less radiation protocol during complex left atrial ablations to minimize radiation exposure for the patient and staff. Methods and results: A total of 150 consecutive patients undergoing left atrial ablations in our hospital were included in the analysis...
March 4, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339457/targeted-aav5-smad7-gene-therapy-inhibits-corneal-scarring-in-vivo
#16
Suneel Gupta, Jason T Rodier, Ajay Sharma, Elizabeth A Giuliano, Prashant R Sinha, Nathan P Hesemann, Arkasubhra Ghosh, Rajiv R Mohan
Corneal scarring is due to aberrant activity of the transforming growth factor β (TGFβ) signaling pathway following traumatic, mechanical, infectious, or surgical injury. Altered TGFβ signaling cascade leads to downstream Smad (Suppressor of mothers against decapentaplegic) protein-mediated signaling events that regulate expression of extracellular matrix and myogenic proteins. These events lead to transdifferentiation of keratocytes into myofibroblasts through fibroblasts and often results in permanent corneal scarring...
2017: PloS One
https://www.readbyqxmd.com/read/28339432/bipolar-versus-unipolar-intraarticular-pulsed-radiofrequency-thermocoagulation-in-chronic-knee-pain-treatment-a-prospective-randomized-trial
#17
Ersel Gulec, Hayri Ozbek, Sinan Pektas, Geylan Isik
BACKGROUND: Chronic knee pain is a major widespread problem causing significant impairment of daily function. Pulsed radiofrequency has been shown to reduce severe chronic joint pain as a non-pharmacological and less invasive treatment method. OBJECTIVE: We aimed to compare the effectiveness of unipolar and bipolar intraarticular pulsed radiofrequency methods in chronic knee pain control. STUDY DESIGN: Prospective, randomized, double-blind study...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339177/multisensory-speech-perception-in-autism-spectrum-disorder-from-phoneme-to-whole-word-perception
#18
Ryan A Stevenson, Sarah H Baum, Magali Segers, Susanne Ferber, Morgan D Barense, Mark T Wallace
Speech perception in noisy environments is boosted when a listener can see the speaker's mouth and integrate the auditory and visual speech information. Autistic children have a diminished capacity to integrate sensory information across modalities, which contributes to core symptoms of autism, such as impairments in social communication. We investigated the abilities of autistic and typically-developing (TD) children to integrate auditory and visual speech stimuli in various signal-to-noise ratios (SNR). Measurements of both whole-word and phoneme recognition were recorded...
March 24, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28339141/don-t-touch-me-autistic-traits-modulate-early-and-late-erp-components-during-visual-perception-of-social-touch
#19
Leehe Peled-Avron, Simone G Shamay-Tsoory
Although individuals with autism spectrum disorder (ASD) have impaired responses to interpersonal touch, the underlying neural correlates remain largely unknown. Here, we examined the neural correlates that underlie interpersonal touch perception in individuals with either high or low autistic traits. Fifty-three participants were classified as having either high or low autistic traits based on their performance on the autism quotient (AQ) questionnaire. We hypothesized that individuals with high AQ scores would have relatively high touch hypervigilance, reflected as earlier P1 and stronger late positive potential (LPP) responses, two components of event-related potentials that serve as electrophysiological markers of anxiety bias...
March 24, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28336779/validation-of-the-semi-quantitative-static-suvr-method-for-18-f-av45-pet-by-pharmacokinetic-modeling-with-an-arterial-input-function
#20
Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Leonie Wyffels, Charisse Somers, Ellen De Roeck, Hanne Struyfs, Femke Soetewey, Steven Deleye, Tobi Van den Bossche, Sara Van Mossevelde, Sarah Ceyssens, Jan Versijpt, Sigrid Stroobants, Sebastiaan Engelborghs, Steven Staelens
Increased brain uptake of [(18)F]-AV45 visualized by PET is a key biomarker for Alzheimer's disease (AD). The standardized uptake value ratio (SUVR) is widely used for quantification, but is subject to variability based on choice of reference region and changes in cerebral blood flow. Here we validate the SUVR method against the gold standard volume of distribution (VT) to assess cross-sectional differences in plaque load. Methods: Dynamic 60-min [(18)F]-AV45 (291 ± 67 MBq) and 1-min [(15)O]-H2O (370 MBq) scans were obtained in 35 age-matched elderly subjects, including 10 probable AD dementia, 15 amnestic mild cognitive impairment (aMCI) and 10 cognitively healthy controls (HC)...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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