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https://www.readbyqxmd.com/read/27933400/-orbital-cavity-tumor-with-macular-folds
#1
M Kitsche, N Terai
A 40-year-old patient presented with an orbital tumor of the right eye accompanied by visual impairment and macular folds. The diagnosis of mucocele was made through clinical and radiological investigations. The excision of the mucocele was performed immediately. As early as 8 weeks after the operation, an obvious increase in visual acuity was noticed. At this time, the macular folds were no longer detectable.
December 8, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27932860/rebound-macular-edema-following-oral-acetazolamide-therapy-for-juvenile-x-linked-retinoschisis-in-an-italian-family
#2
Maria Silvana Galantuomo, Maurizio Fossarello, Alberto Cuccu, Roberta Farci, Markus N Preising, Birgit Lorenz, Pietro Emanuele Napoli
BACKGROUND: Juvenile X-linked retinoschisis (RS1, OMIM: 312700) is a hereditary vitreoretinal dystrophy characterized by bilateral foveal schisis and, in half of the patients, splitting through the nerve fiber layer in the peripheral retina. In the first decade of life, patients usually develop a decrease in visual acuity. Long-term visual outcomes can be poor due to the limited number of known successful treatments. PURPOSE: The purposes of this study were to present, for the first time, a p...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27932344/using-robust-normative-data-to-investigate-the-neuropsychology-of-cognitive-aging
#3
Karra D Harrington, Yen Ying Lim, David Ames, Jason Hassenstab, Stephanie Rainey-Smith, Joanne Robertson, Olivier Salvado, Colin L Masters, Paul Maruff
OBJECTIVE: The extent to which increasing age is associated with impairment in cognitive function, termed cognitive aging, may have been overestimated in prior studies. The inclusion of individuals with severe or uncontrolled systemic medical illness or prodromal neurodegenerative disease in normal aging samples is likely to bias estimates toward lower cognitive performance and inflate estimates of variability. METHOD: Unbiased estimates of cognitive aging in 658 adults aged 60-84, who underwent rigorous screening to ensure their general and cognitive health, were computed...
December 8, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27931205/assessment-of-near-visual-acuity-in-0-13-year-olds-with-normal-and-low-vision-a-systematic-review
#4
Bianca Huurneman, F Nienke Boonstra
BACKGROUND: The inclusion for rehabilitation of visually impaired children is partly based on the measurement of near vision, but guidelines for near visual acuity assessment are currently lacking. The twofold purpose of this systematic review was to: (i) provide an overview of the impact of the chart design on near visual acuity measured, and (ii) determine the method of choice for near vision assessments in children of different developmental ages. METHODS: A literature search was conducted by using the following electronic databases: PubMed, Cochrane Library, and EMBASE...
December 8, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27930898/changed-crossmodal-functional-connectivity-in-older-adults-with-hearing-loss
#5
Sebastian Puschmann, Christiane M Thiel
Previous work compellingly demonstrates a crossmodal plastic reorganization of auditory cortex in deaf individuals, leading to increased neural responses to non-auditory sensory input. Recent data indicate that crossmodal adaptive plasticity is not restricted to severe hearing impairments, but may also occur as a result of high-frequency hearing loss in older adults and affect audiovisual processing in these subjects. We here used functional magnetic resonance imaging (fMRI) to study the effect of hearing loss in older adults on auditory cortex response patterns as well as on functional connectivity between auditory and visual cortex during audiovisual processing...
October 31, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27930593/usefulness-of-3-dimensional-stereotactic-surface-projection-fdg-pet-images-for-the-diagnosis-of-dementia
#6
Jahae Kim, Sang-Geon Cho, Minchul Song, Sae-Ryung Kang, Seong Young Kwon, Kang-Ho Choi, Seong-Min Choi, Byeong-Chae Kim, Ho-Chun Song
To compare diagnostic performance and confidence of a standard visual reading and combined 3-dimensional stereotactic surface projection (3D-SSP) results to discriminate between Alzheimer disease (AD)/mild cognitive impairment (MCI), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD).[F]fluorodeoxyglucose (FDG) PET brain images were obtained from 120 patients (64 AD/MCI, 38 DLB, and 18 FTD) who were clinically confirmed over 2 years follow-up. Three nuclear medicine physicians performed the diagnosis and rated diagnostic confidence twice; once by standard visual methods, and once by adding of 3D-SSP...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27928411/visual-impairment-due-to-lissencephaly
#7
V E Marqués-Fernández, H Sánchez-Tocino, M T Escudero-Caro, R Cancho-Candela, M García-Zamora
Lissencephaly is a rare disorder due to abnormal neural migration, causing neurological impairment and clinically characterised by mental retardation and epilepsy. Any disturbance of the visual pathway can cause loss of vision. The authors describe a case of a 6-year-old boy referred to the ophthalmologist presenting poor bilateral vision. This child had no other known medical conditions, and neurological examination was completely normal. Only when a magnetic resonance imaging was made that a lissencephaly-pachygyria with band heterotopia mostly occipital was noted...
October 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27928386/current-perspectives-of-bioptic-driving-in-low-vision
#8
REVIEW
Robert Chun, Maria Cucuras, Walter M Jay
In this review, the authors discuss the current perspectives of spectacle-mounted telescopes (bioptics) used for driving among patients with vision impairments. The history, design, driving laws surrounding bioptic use, and developing programs in The Netherlands and Canada are discussed. Patients who have certain visual requirements and stable disease status may be eligible candidates to consider using a bioptic aid for driving. Given the high prevalence of depression among visually impaired patients, low vision specialists can work with neuro-ophthalmologists to maximise the independence and visual function of patients who have permanent vision impairments but capable of maintaining driving privileges...
April 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27928375/a-randomised-controlled-trial-of-treatment-for-post-stroke-homonymous-hemianopia-screening-and-recruitment
#9
Fiona J Rowe, Elizabeth J Conroy, P Graham Barton, Emma Bedson, Emma Cwiklinski, Caroline Dodridge, Avril Drummond, Marta Garcia-Finana, Claire Howard, Stevie Johnson, Claire MacIntosh, Carmel P Noonan, Alex Pollock, Janet Rockliffe, Catherine M Sackley, Tracey Shipman
The authors report the screening process and recruitment figures for the VISION (Visual Impairment in Stroke; Intervention Or Not) trial. This is a prospective, randomised, single-blinded, three-arm controlled trial in 14 UK acute hospital stroke units. Stroke teams identified stroke survivors suspected as having homonymous hemianopia. Interventions included Fresnel prisms versus visual search training versus standard care (information only). Primary outcome was change in visual field assessment from baseline to 26 weeks...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27928252/effects-of-passion-flower-extract-as-an-add-on-treatment-to-sertraline-on-reaction-time-in-patients-%C3%A2-with-generalized-anxiety-disorder-a-double-blind-placebo-controlled-study
#10
Mandana Nojoumi, Padideh Ghaeli, Samrand Salimi, Ali Sharifi, Firoozeh Raisi
Objective: Because of functional impairment caused by generalized anxiety disorder and due to cognitive side ‎effects of many anti-anxiety agents, in this study we aimed to evaluate the influence of Passion ‎flower standardized extract on reaction time in patients with generalized anxiety disorder.‎ Method: Thirty patients aged 18 to 50 years of age, who were diagnosed with generalized anxiety disorder and ‎fulfilled the study criteria, entered this double-blind placebo-controlled study. Reaction time was ‎measured at baseline and after one month of treatment using computerized software...
July 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/27927703/pharmacokinetics-and-pharmacodynamics-of-oral-mecamylamine-development-of-a-nicotinic-acetylcholine-receptor-antagonist-cognitive-challenge-test-using-modelling-and-simulation
#11
Ricardo Alvarez-Jimenez, Anne Catrien Baakman, Jasper Stevens, Sebastiaan C Goulooze, Ellen P Hart, Robert Rissmann, Joop Ma van Gerven, Geert Jan Groeneveld
A pharmacologic challenge model with a nicotinic antagonist could be an important tool not only to understand the complex role of the nicotinic cholinergic system in cognition, but also to develop novel compounds acting on the nicotinic acetylcholine receptor. The objective was to develop a pharmacokinetic-pharmacodynamic (PKPD) model using nonlinear mixed effects (NLME) methods to quantitate the pharmacokinetics of three oral mecamylamine doses (10, 20 and 30 mg) and correlate the plasma concentrations to the pharmacodynamic effects on a cognitive and neurophysiologic battery of tests in healthy subjects...
December 7, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27927083/measurement-of-peripheral-vision-reaction-time-identifies-white-matter-disruption-in-patients-with-mild-traumatic-brain-injury
#12
Kyle B Womack, Christopher Paliotta, Jeremy F Strain, Johnson S Ho, Yosef S Skolnick, William W Lytton, L Christine Turtzo, Roderick McColl, Ramon Diaz-Arrastia, Peter Bergold
This study examined whether peripheral vision reaction time (PVRT) in patients with mild traumatic brain injury (mTBI) correlate with white matter abnormalities in centroaxial structures and impairments in neuropsychological testing. Within 24 hours after mTBI, crossed reaction times (CRT), uncrossed reaction times (URT) and crossed-uncrossed difference (CUD) were measured in 23 patients using a laptop computer that displayed visual stimuli predominantly to either the left or right visual field of the retina...
December 7, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27926893/erratum-global-estimates-on-the-number-of-people-blind-or-visually-impaired-by-diabetic-retinopathy-a-meta-analysis-from-1990-2010-diabetes-care-2016-39-1643-1649
#13
Janet L Leasher, Rupert R A Bourne, Seth R Flaxman, Jost B Jonas, Jill Keeffe, Novin Naidoo, Konrad Pesudovs, Holly Price, Richard A White, Tien Y Wong, Serge Resnikoff, Hugh R Taylor
No abstract text is available yet for this article.
November 2016: Diabetes Care
https://www.readbyqxmd.com/read/27926760/epidermal-nerve-fiber-quantification-in-patients-with-erythromelalgia
#14
William G Mantyh, P James B Dyck, Peter J Dyck, Janean K Engelstad, William J Litchy, Paola Sandroni, Mark D P Davis
Importance: Erythromelalgia is a clinical diagnosis based on intermittent warmth, erythema, and pain in the distal extremities. One problem facing physicians is how to objectively test for this disease. Given that other painful conditions of the distal extremities (ie, neuropathy related to human immunodeficiency virus, diabetes, or Fabry disease) can be evaluated with a skin biopsy to visualize pathologically decreased densities of the small nerve fibers that innervate the epidermis, one hypothesis is that erythromelalgia could similarly be associated with a loss of epidermal nerve fiber density (ENFD)...
December 7, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27925145/the-oldest-old-in-the-emergency-department-impact-of-renal-function
#15
T Brünnler, M Drey, G Dirrigl, C Weingart, F Rockmann, C Sieber, U Hoffmann
OBJECTIVES: The ageing population implicates an increasing numbers of older adults attending Emergency Departments (ED). We assessed the effect of estimated glomerular filtration rate as a predictor of clinical outcomes in oldest-old patients ≥ 85 years attending the ED in an university teaching hospital. DESIGN: Within three years, 81831 patient contacts were made in our ED. 7799 (9.5%) were older than 85 years, in whom we analyzed the impact of renal function on various outcome parameters...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27925055/lung-protection-an-intervention-for-tidal-volume-reduction-in-a-teaching-intensive-care-unit
#16
Arturo Briva, Cristina Gaiero
Objective: To determine the effect of feedback and education regarding the use of predicted body weight to adjust tidal volume in a lung-protective mechanical ventilation strategy. Methods: The study was performed from October 2014 to November 2015 (12 months) in a single university polyvalent intensive care unit. We developed a combined intervention (education and feedback), placing particular attention on the importance of adjusting tidal volumes to predicted body weight bedside...
December 1, 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27924740/so-let-me-find-my-way-whatever-it-will-cost-me-rather-than-leaving-myself-in-darkness-experiences-of-glaucoma-in-nigeria
#17
Fatima Kyari, Clare I Chandler, Martha Martin, Clare E Gilbert
BACKGROUND: Blindness from glaucoma is associated with socio-economic deprivation, presumed to reflect poor access to care and poor adherence to treatment. OBJECTIVES: To determine why people with glaucoma are presenting late for treatment and to understand access to glaucoma care. Additionally, we sought to identify what patients and the community know, do and think about the condition and why the poor are the most affected with glaucoma blindness. DESIGN: Study participants were from four communities and two hospitals in Abuja-FCT and Kaduna State, Nigeria...
2016: Global Health Action
https://www.readbyqxmd.com/read/27924444/bindings-in-working-memory-the-role-of-object-based-attention
#18
Zaifeng Gao, Fan Wu, Fangfang Qiu, Kaifeng He, Yue Yang, Mowei Shen
Over the past decade, it has been debated whether retaining bindings in working memory (WM) requires more attention than retaining constituent features, focusing on domain-general attention and space-based attention. Recently, we proposed that retaining bindings in WM needs more object-based attention than retaining constituent features (Shen, Huang, & Gao, 2015, Journal of Experimental Psychology: Human Perception and Performance, doi: 10.1037/xhp0000018 ). However, only unitized visual bindings were examined; to establish the role of object-based attention in retaining bindings in WM, more emperical evidence is required...
December 6, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27923908/estrogen-activation-of-microglia-underlies-the-sexually-dimorphic-differences-in-nf1-optic-glioma-induced-retinal-pathology
#19
Joseph A Toonen, Anne C Solga, Yu Ma, David H Gutmann
Children with neurofibromatosis type 1 (NF1) develop low-grade brain tumors throughout the optic pathway. Nearly 50% of children with optic pathway gliomas (OPGs) experience visual impairment, and few regain their vision after chemotherapy. Recent studies have revealed that girls with optic nerve gliomas are five times more likely to lose vision and require treatment than boys. To determine the mechanism underlying this sexually dimorphic difference in clinical outcome, we leveraged Nf1 optic glioma (Nf1-OPG) mice...
December 6, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27923790/dynamin-related-protein-1-mediates-low-glucose-induced-endothelial-dysfunction-in-human-arterioles
#20
Michael John Tanner, Jingli Wang, Rong Ying, Tisha B Suboc, Mobin Malik, Allison Couillard, Amberly Branum, Venkata Puppala, Michael Eric Widlansky
Intensive glycemic regulation has resulted in an increased incidence of hypoglycemia. Hypoglycemic burden correlates with adverse cardiovascular complications and contributes acutely and chronically to endothelial dysfunction. Prior data indicate mitochondrial dysfunction contributes to hypoglycemia-induced endothelial dysfunction, but the mechanisms behind this linkage remain unknown. We attempt to determine whether clinically relevant low glucose (LG) exposures acutely induce endothelial dysfunction through activation of the mitochondrial fission process...
December 6, 2016: American Journal of Physiology. Heart and Circulatory Physiology
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