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premetastatic niche

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https://www.readbyqxmd.com/read/28148719/matricellular-proteins-tune-myeloid-derived-suppressor-cell-recruitment-and-function-in-breast-cancer
#1
REVIEW
Claudia Chiodoni, Sabina Sangaletti, Mario P Colombo
Solid tumor progression is often associated with the expansion of myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells that actively foster tumor growth and metastatic dissemination through a plethora of mechanisms, including, but not limited to, their major suppressive activity on the immune response. Indeed, MDSCs may sustain tumor progression by dynamically remodeling the tumor microenvironment through the production of angiogenic factors and metalloproteases, by helping the establishment of a premetastatic niche, and by promoting stemness and epithelial-to-mesenchymal transition (EMT) features in tumor cells...
February 1, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28069800/label-free-raman-spectroscopy-detects-stromal-adaptations-in-premetastatic-lungs-primed-by-breast-cancer
#2
Santosh Kumar Paidi, Asif Rizwan, Chao Zheng, Menglin Cheng, Kristine Glunde, Ishan Barman
Recent advances in animal modeling, imaging technology, and functional genomics have permitted precise molecular observations of the metastatic process. However, a comprehensive understanding of the premetastatic niche remains elusive, owing to the limited tools that can map subtle differences in molecular mediators in organ-specific microenvironments. Here, we report the ability to detect premetastatic changes in the lung microenvironment, in response to primary breast tumors, using a combination of metastatic mouse models, Raman spectroscopy, and multivariate analysis of consistent patterns in molecular expression...
January 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28036019/lymph-nodes-and-cancer-metastasis-new-perspectives-on-the-role-of-intranodal-lymphatic-sinuses
#3
REVIEW
Rui-Cheng Ji
The lymphatic system is essential for transporting interstitial fluid, soluble antigen, and immune cells from peripheral tissues to lymph nodes (LNs). Functional integrity of LNs is dependent on intact lymphatics and effective lymph drainage. Molecular mechanisms that facilitate interactions between tumor cells and lymphatic endothelial cells (LECs) during tumor progression still remain to be identified. The cellular and molecular structures of LNs are optimized to trigger a rapid and efficient immune response, and to participate in the process of tumor metastasis by stimulating lymphangiogenesis and establishing a premetastatic niche in LNs...
December 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28031234/the-multiple-roles-of-exosomes-in-metastasis
#4
REVIEW
Ulrich H Weidle, Fabian Birzele, Gwen Kollmorgen, Rüdiger Rüger
Exosomes are important contributors to cell-cell communication and their role as diagnostic markers for cancer and the pathogenesis for cancer is under intensive investigation. Here, we focus on their role in metastasis-related processes. We discuss their impact regarding promotion of invasion and migration of tumor cells, conditioning of lymph nodes, generation of premetastatic niches and organotropism of metastasis. Furthermore, we highlight interactions of exosomes with bone marrow and stromal components such as fibroblasts, endothelial cells, myeloid- and other immune-related cells in the context of metastases...
January 2, 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27959340/e-selectin-targeting-pegylated-thioaptamer-prevents-breast-cancer-metastases
#5
Yoshihiro Morita, Mohamed Kamal, Shin-Ae Kang, Roy Zhang, Ganesh Lr Lokesh, Varatharasa Thiviyanathan, Nafis Hasan, Sukyung Woo, Daniel Zhao, Macall Leslie, Stephen Suh, Wajeeha Razaq, Hallgeir Rui, David G Gorenstein, David E Volk, Takemi Tanaka
E-selectin is an adhesion molecule expressed on the luminal surface of inflamed blood vessels that mediates hematogenous metastasis by assisting shear-resistant adhesion of circulating tumor cells to the vessel surface under dynamic blood flow. Previously, we developed an E-selectin antagonistic thioaptamer (ESTA) for the prevention of hematogenous metastasis through the blockade of CD44(high) breast cancer cells (BCa) adhesion to E-selectin-expressing premetastatic endothelial niche. The current study focuses on developing a PEGylated E-selectin targeting thioaptamer with improved pharmaceutical properties...
December 13, 2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27885671/recruited-monocytic-myeloid-derived-suppressor-cells-promote-the-arrest-of-tumor-cells-in-the-premetastatic-niche-through-an-il-1%C3%AE-mediated-increase-in-e-selectin-expression
#6
Huifang Shi, Juechao Zhang, Xiaoqing Han, Huihan Li, Mingshu Xie, Yingying Sun, Wenguang Liu, Xueqing Ba, Xianlu Zeng
The tumor premetastatic niche initiated by primary tumors is constructed by multiple molecular factors and cellular components and provides permissive condition that allows circulating tumor cells to successfully metastasize. Myeloid-derived suppressor cells (MDSCs), a population of immature cells in pathological conditions, play a critical role in the formation of the premetastatic niche. However, few researches are focused on the function of monocytic MDSCs (mo-MDSCs), a subtype of MDSCs, in the construction of the niche...
March 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27813080/protein-content-and-functional-characteristics-of-serum-purified-exosomes-from-patients-with-colorectal-cancer-revealed-by-quantitative-proteomics
#7
Yanyu Chen, Yong Xie, Lai Xu, Shaohua Zhan, Yi Xiao, Yanpan Gao, Bin Wu, Wei Ge
Tumor cells of colorectal cancer (CRC) release exosomes into the circulation. These exosomes can mediate communication between cells and affect various tumor-related processes in their target cells. We present a quantitative proteomics analysis of the exosomes purified from serum of patients with CRC and normal volunteers; data are available via ProteomeXchange with identifier PXD003875. We identified 918 proteins with an overlap of 725 Gene IDs in the Exocarta proteins list. Compared with the serum-purified exosomes (SPEs) of normal volunteers, we found 36 proteins upregulated and 22 proteins downregulated in the SPEs of CRC patients...
February 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27756426/exosomes-in-tumor-microenvironment-novel-transporters-and-biomarkers
#8
Zhen Wang, Jun-Qiang Chen, Jin-Lu Liu, Lei Tian
Tumor microenvironment (TME) plays an integral part in the biology of cancer, participating in tumor initiation, progression, and response to therapy. Exosome is an important part of TME. Exosomes are small vesicles formed in vesicular bodies with a diameter of 30-100 nm and a classic "cup" or "dish" morphology. They can contain microRNAs, mRNAs, DNA fragments and proteins, which are shuttled from a donor cell to recipient cells. Exosomes secreted from tumor cells are called tumor-derived (TD) exosomes. There is emerging evidence that TD exosomes can construct a fertile environment to support tumor proliferation, angiogenesis, invasion and premetastatic niche preparation...
October 19, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27223426/platelet-factor-4-is-produced-by-subsets-of-myeloid-cells-in-premetastatic-lung-and-inhibits-tumor-metastasis
#9
Jiang Jian, Yanli Pang, H Hannah Yan, Yongfen Min, Bhagelu R Achyut, M Christine Hollander, P Charles Lin, Xinhua Liang, Li Yang
Bone marrow-derived myeloid cells can form a premetastatic niche and provide a tumor-promoting microenvironment. However, subsets of myeloid cells have also been reported to have anti-tumor properties. It is not clear whether there is a transition between anti- and pro- tumor function of these myeloid cells, and if so, what are the underlying molecular mechanisms. Here we report platelet factor 4 (PF4), or CXCL4, but not the other family members CXCL9, 10, and 11, was produced at higher levels in the normal lung and early stage premetastatic lungs but decreased in later stage lungs...
May 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27157716/exosome-mediated-metastasis-from-epithelial-mesenchymal-transition-to-escape-from-immunosurveillance
#10
REVIEW
Nicholas Syn, Lingzhi Wang, Gautam Sethi, Jean-Paul Thiery, Boon-Cher Goh
Exosomes are extracellular signalosomes that facilitate eukaryotic intercellular communication under a wide range of normal physiological contexts. In malignancies, this regulatory circuit is co-opted to promote cancer cell survival and outgrowth. Tumour-derived exosomes (TDEs) carry a pro-EMT (epithelial-mesenchymal transition) programme including transforming growth factor beta (TGFβ), caveolin-1, hypoxia-inducible factor 1 alpha (HIF1α), and β-catenin that enhances the invasive and migratory capabilities of recipient cells, and contributes to stromal remodelling and premetastatic niche formation...
July 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27006653/cancer-associated-immune-resistance-and-evasion-of-immune-surveillance-in-colorectal-cancer
#11
REVIEW
Pietro Parcesepe, Guido Giordano, Carmelo Laudanna, Antonio Febbraro, Massimo Pancione
Data from molecular profiles of tumors and tumor associated cells provide a model in which cancer cells can acquire the capability of avoiding immune surveillance by expressing an immune-like phenotype. Recent works reveal that expression of immune antigens (PDL1, CD47, CD73, CD14, CD68, MAC387, CD163, DAP12, and CD15) by tumor cells "immune resistance," combined with prometastatic function of nonmalignant infiltrating cells, may represent a strategy to overcome the rate-limiting steps of metastatic cascade through (a) enhanced interactions with protumorigenic myeloid cells and escape from T-dependent immune response mediated by CD8+ and natural killer (NK) cells; (b) production of immune mediators that establish a local and systemic tumor-supportive environment (premetastatic niche); (c) ability to survive either in the peripheral blood as circulating tumor cells (CTCs) or at the metastatic site forming a cooperative prometastatic loop with foreign "myeloid" cells, macrophages, and neutrophils, respectively...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/26937132/emerging-molecular-basis-of-hematogenous-metastasis-in-gastric-cancer
#12
REVIEW
Jing Zhong, Yan Chen, Liang-Jing Wang
Lymphatic metastasis is commonly observed in gastric cancer (GC), but hematogenous metastasis is more likely responsible for the cancer-related mortality. Since Stephen Paget first introduced the "seed and soil hypothesis" a century ago, growing evidence recognizes that numerous essential secreted factors and signaling pathway effectors participate in the pre-metastatic niche formation and distant organ metastasis. The cross-talk between GC cells and surrounding microenvironment may consist of a series of interrelated steps, including epithelial mesenchymal transition, intravasation into blood vessels, circulating tumor cell translocation, and secondary organ metastasis...
February 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26909582/increased-angiogenesis-and-lymphangiogenesis-in-metastatic-sentinel-lymph-nodes-is-associated-with-nonsentinel-lymph-node-involvement-and-distant-metastasis-in-patients-with-melanoma
#13
MULTICENTER STUDY
Ievgenia Pastushenko, Gert G Van den Eynden, Sandra Vicente-Arregui, Lucia Prieto-Torres, Ramiro Alvarez-Alegret, Ignacio Querol, Luc Y Dirix, Francisco J Carapeto, Peter B Vermeulen, Steven J Van Laere
Lymph node angio- and lymphangio-genesis have been shown to play an important role in the premetastatic niche of sentinel lymph nodes. In the current study we have investigated the association of angio- and lympangio-genesis related parameters in metastatic sentinel lymph nodes of patients with melanoma with the presence of nonsentinel and distant organ metastasis. Peritumoral and intratumoral relative blood and lymphatic vessel areas (evaluated by Chalkley method), blood and lymphatic microvessel densities, and the rates of blood and lymphatic vessel proliferation were assessed in primary tumors and sentinel lymph node metastasis of 44 patients with melanoma using CD34/Ki-67 and D240/Ki-67 immunohistochemical double staining...
May 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26899533/clinical-and-biological-significance-of-circulating-tumor-cells-in-cancer
#14
REVIEW
Takaaki Masuda, Naoki Hayashi, Tomohiro Iguchi, Shuhei Ito, Hidetoshi Eguchi, Koshi Mimori
During the process of metastasis, which is the leading cause of cancer-related death, cancer cells dissociate from primary tumors, migrate to distal sites, and finally colonize, eventually leading to the formation of metastatic tumors. The migrating tumor cells in circulation, e.g., those found in peripheral blood (PB) or bone marrow (BM), are called circulating tumor cells (CTCs). CTCs in the BM are generally called disseminated tumor cells (DTCs). Many studies have reported the detection and characterization of CTCs to facilitate early diagnosis of relapse or metastasis and improve early detection and appropriate treatment decisions...
March 2016: Molecular Oncology
https://www.readbyqxmd.com/read/26707854/the-role-of-exosomes-in-tumor-progression-and-metastasis-review
#15
REVIEW
Wiktoria M Suchorska, Michal S Lach
Tumor cells have developed various mechanisms in defense against applied treatment, which prevent their total elimination from an organism. One of the underestimated mechanisms of defense is secretion of highly specialized double-membrane structures called exosomes. They play a crucial role in the control of the local microenvironment and intracellular communication. It has been shown that the exosomes can be carriers of various proteins, lipids, miRNAs and mRNAs. There are extensive data concerning the influence and participation by exosomes in metastasis and cancer progression...
March 2016: Oncology Reports
https://www.readbyqxmd.com/read/26675257/exosomes-from-bulk-and-stem-cells-from-human-prostate-cancer-have-a-differential-microrna-content-that-contributes-cooperatively-over-local-and-pre-metastatic-niche
#16
Catherine A Sánchez, Eliana I Andahur, Rodrigo Valenzuela, Enrique A Castellón, Juan A Fullá, Christian G Ramos, Juan C Triviño
The different prostate cancer (PCa) cell populations (bulk and cancer stem cells, CSCs) release exosomes that contain miRNAs that could modify the local or premetastatic niche. The analysis of the differential expression of miRNAs in exosomes allows evaluating the differential biological effect of both populations on the niche, and the identification of potential biomarkers and therapeutic targets. Five PCa primary cell cultures were established to originate bulk and CSCs cultures. From them, exosomes were purified by precipitation for miRNAs extraction to perform a comparative profile of miRNAs by next generation sequencing in an Illumina platform...
January 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/26667458/exosomes-in-cancer-disease
#17
Margot Zöller
Cancer diagnosis and therapy is steadily improving. Still, diagnosis is frequently late and diagnosis and follow-up procedures mostly are time-consuming and expensive. Searching for tumor-derived exosomes (TEX) in body fluids may provide an alternative, minimally invasive, yet highly reliable diagnostic tool. Beyond this, there is strong evidence that TEX could become a potent therapeutics. Exosomes, small vesicles delivered by many cells of the organism, are found in all body fluids. Exosomes are characterized by lipid composition, common and donor cell specific proteins, mRNA, small non-coding RNA including miRNA and DNA...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26483204/ccl9-induced-by-tgf%C3%AE-signaling-in-myeloid-cells-enhances-tumor-cell-survival-in-the-premetastatic-organ
#18
Hangyi H Yan, Jian Jiang, Yanli Pang, B R Achyut, Michael Lizardo, Xinhua Liang, Kent Hunter, Chand Khanna, Christine Hollander, Li Yang
Tumor cell survival in the hostile distant organ is a rate-limiting step in cancer metastasis. Bone marrow-derived myeloid cells can form a premetastatic niche and provide a tumor-promoting microenvironment. However, it is unclear whether these myeloid cells in the premetastatic site have any direct effect on tumor cell survival. Here, we report that chemokine CCL9 was highly induced in Gr-1(+)CD11b(+) immature myeloid cells and in premetastatic lung in tumor-bearing mice. Knockdown of CCL9 in myeloid cells decreased tumor cell survival and metastasis...
December 15, 2015: Cancer Research
https://www.readbyqxmd.com/read/26450920/clinical-and-translational-assessment-of-vegfr1-as-a-mediator-of-the-premetastatic-niche-in-high-risk-localized-prostate-cancer
#19
Sumanta Kumar Pal, Winston Vuong, Wang Zhang, Jiehui Deng, Xueli Liu, Courtney Carmichael, Nora Ruel, Manasvi Pinnamaneni, Przemyslaw Twardowski, Clayton Lau, Hua Yu, Robert A Figlin, Neeraj Agarwal, Jeremy O Jones
Preclinical studies have suggested that VEGFR1-positive cells potentially foster the development of metastases by establishing a "premetastatic niche." We sought to test this hypothesis in high-risk localized prostate cancer and assess potential niche modulation by the VEGFR1-targeting drug axitinib. Formalin-fixed, paraffin-embedded tissue derived from benign lymph nodes was collected and VEGFR1-positive cell clustering was assessed in benign lymph nodes via IHC. Recursive partitioning was used to define a threshold for VEGFR1 clustering that could segregate patients based on time to biochemical recurrence (TTBR)...
December 2015: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/26408927/tissue-factor-old-and-new-links-with-cancer-biology
#20
REVIEW
Henri H Versteeg
Blood coagulation is one of the most profound factors that influence cancer progression. Especially the initiator of coagulation, tissue factor (TF), has been subject to many studies investigating the overlap between coagulation and cancer. It has been known for decades that TF is a risk factor for metastasis, and in mouse models, TF drives metastasis in a coagulation-dependent manner. However, TF also serves as a cellular receptor to drive primary tumor growth and tumor angiogenesis. Nevertheless, recent studies have indicated that TF plays more fundamental roles in cancer biology...
October 2015: Seminars in Thrombosis and Hemostasis
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