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https://www.readbyqxmd.com/read/28460574/the-neurogenic-compound-nsi-189-phosphate-a-novel-multi-domain-treatment-capable-of-pro-cognitive-and-antidepressant-effects
#1
REVIEW
Roger S McIntyre, Karl Johe, Carola Rong, Yena Lee
Alterations in neurogenic and neurotrophic processes as well as intracellular signalling cascades provides the basis for hypothesizing that neurogenic agents may be therapeutic across multiple RDoC-defined domains (e.g. positive valence systems, general cognitive processes). Moreover, using the DSM-5 taxonomy, neurogenic agents may mitigate symptoms in adults with depressive and bipolar disorders as well as individuals with cognitive disorders. Areas covered: NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo...
June 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28181668/nsi-189-a-small-molecule-with-neurogenic-properties-exerts-behavioral-and-neurostructural-benefits-in-stroke-rats
#2
Naoki Tajiri, David M Quach, Yuji Kaneko, Stephanie Wu, David Lee, Tina Lam, Ken L Hayama, Thomas G Hazel, Karl Johe, Michael C Wu, Cesar V Borlongan
Enhancing neurogenesis may be a powerful stroke therapy. Here, we tested in a rat model of ischemic stroke the beneficial effects of NSI-189, an orally active, new molecular entity (mol. wt. 366) with enhanced neurogenic activity, and indicated as an anti-depressant drug in a clinical trial (Fava et al., , Molecular Psychiatry, DOI: 10.1038/mp.2015.178) and being tested in a Phase 2 efficacy trial (ClinicalTrials.gov, , ClinicalTrials.gov Identifier: NCT02695472) for treatment of major depression. Oral administration of NSI-189 in adult Sprague-Dawley rats starting at 6 hr after middle cerebral artery occlusion, and daily thereafter over the next 12 weeks resulted in significant amelioration of stroke-induced motor and neurological deficits, which was maintained up to 24 weeks post-stroke...
October 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27528461/a-phase-1b-randomized-double-blind-placebo-controlled-multiple-dose-escalation-study-of-nsi-189-phosphate-a-neurogenic-compound-in-depressed-patients
#3
M Fava, K Johe, L Ereshefsky, L G Gertsik, B A English, J A Bilello, L M Thurmond, J Johnstone, B C Dickerson, N Makris, B B Hoeppner, M Flynn, D Mischoulon, G Kinrys, M P Freeman
No abstract text is available yet for this article.
October 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26643541/a-phase-1b-randomized-double-blind-placebo-controlled-multiple-dose-escalation-study-of-nsi-189-phosphate-a-neurogenic-compound-in-depressed-patients
#4
M Fava, K Johe, L Ereshefsky, L G Gertsik, B A English, J A Bilello, L M Thurmond, J Johnstone, B C Dickerson, N Makris, B B Hoeppner, M Flynn, D Mischoulon, G Kinrys, M P Freeman
We wanted to examine tolerability and efficacy of NSI-189, a benzylpiperizine-aminiopyridine neurogenic compound for treating major depressive disorder (MDD). This was a Phase 1B, double blind, randomized, placebo controlled, multiple-dose study with three cohorts. The first cohort received 40 mg q.d. (n=6) or placebo (n=2), the second cohort 40 mg b.i.d. (n=6) or placebo (n=2), and the third cohort 40 mg t.i.d. (n=6) or placebo (n=2). Twenty-four patients with MDD were recruited, with the diagnosis and severity confirmed through remote interviews...
October 2016: Molecular Psychiatry
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