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Gnrh agonist trigger

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https://www.readbyqxmd.com/read/29037085/luteal-phase-serum-progesterone-levels-after-gnrh-agonist-trigger-how-low-is-still-high-enough-for-an-ongoing-pregnancy
#1
B Lawrenz, S Samir, L Melado, F Ruiz, H M Fatemi
In the past years, individualization of assisted reproductive technique (ART)-treatment is increasingly common to customize the treatment protocol to the patient's specific conditions. The use of GnRH-agonist for final oocyte maturation in a gonadotropin-releasing hormone (GnRH)-antagonist protocol is the best approach to reduce the risk for ovarian hyperstimulation in high responder patients. However, due to severe luteolysis, the reproductive outcome with this approach in combination with the use of vaginal progesterone as luteal phase support, was poor...
October 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28957685/dual-trigger-of-final-oocyte-maturation-with-a-combination-of-gnrh-agonist-and-hcg-versus-a-hcg-alone-trigger-in-gnrh-antagonist-cycle-for-in-vitro-fertilization-a-systematic-review-and-meta-analysis
#2
REVIEW
Nan Ding, Xingchen Liu, Qiliang Jian, Zhongzhen Liang, Fang Wang
OBJECTIVE: Increasing evidence indicates that a dual trigger (a gonadotrophin-releasing hormone agonist [GnRH-a] with a human chorionic gonadotrophin [hCG] trigger) is the best choice for final oocyte maturation in the GnRH antagonist (GnRH-ant) cycle. However, this conclusion remains controversial. Therefore, we performed this meta-analysis to systematically evaluate the efficacy of a GnRH-a combined with a standard hCG trigger in comparison with hCG alone for final oocyte maturation in the GnRH-ant cycle for in vitro fertilization...
September 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28939988/frozen-embryo-transfer-can-be-performed-in-the-cycle-immediately-following-the-freeze-all-cycle
#3
Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Peter Humaidan, Kevin Coetzee
PURPOSE: In this study, we investigated whether the time interval between oocyte retrieval and frozen embryo transfer (FET) affected the live birth (LB) rates of human segmented-IVF cycles. METHOD: A total of 1338 ICSI freeze-all cycles were performed between February 2015 and January 2016, with 1121 FET cycles being retrospectively analyzed. All vitrified-warmed blastocyst transfers were performed in artificial FET cycles, using gonadotropin-releasing hormone (GnRH) agonist downregulation and oral estrogen endometrial preparation...
September 22, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28933569/day-two-post-retrieval-1500-iui-hcg-bolus-progesterone-free-luteal-support-post-gnrh-agonist-trigger-a-proof-of-concept-study
#4
Sharon Vanetik, Linoy Segal, Tatiana Breizman, Shahar Kol
Small dose of hCG (1500 IU) on the day of oocyte retrieval, followed by daily progesterone administration, is currently the preferred way to secure adequate luteal support following GnRH agonist trigger. In the current proof-of-concept study, we explored the possibility that a bolus of 1500 IU hCG, given two days after oocyte retrieval, may be sufficient to sustain adequate luteal support without additional progesterone treatment. From February 2015 to August 2016, we obtained 44 pregnancies following GnRHa trigger followed by day 2 hCG (1500 IU) support only (study group)...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28916209/towards-new-strategies-to-manage-livestock-reproduction-using-kisspeptin-analogs
#5
M Beltramo, C Decourt
The discovery of the hypothalamic neuropeptide kisspeptin and its receptor (KISS1R) have dramatically improved our knowledge about the central mechanisms controlling reproduction. Kisspeptin neurons could be considered the hub where internal and external information controlling reproduction converge. The information is here elaborated and the command dispatched to GnRH neurons, the final output of the brain system controlling reproduction. Several studies have shown that in mammals administration of kisspeptin could finely modulate many aspects of reproduction from puberty to ovulation...
September 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/28904504/role-of-serpine-gene-polymorphism-in-recurrent-implantation-failure-and-preeclampsia
#6
Nidhi Sharma, Jayashree K Srinivasan, Margeret Harriet Priya, Venkatachalam Sibiya
This is a rare case of serpine gene polymorphism causing thrombophilia and recurrent implantation failure following intrauterine insemination. SERPINE1 gene encodes plasminogen activator inhibitor type 1 and inhibits fibrinolysis, or clot dissolution. The 4G variant results in increased expression of SERPINE1 and consequently higher inhibition of fibrinolysis, thus leading to thrombophilia. The patient had unexplained primary infertility for 9 years. Ovulation induction was done with gonadotropin releasing hormone (GnRH) agonist long protocol...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28865552/gonadotropin-releasing-hormone-agonist-trigger-increases-the-number-of-oocytes-and-embryos-available-for-cryopreservation-in-cancer-patients-undergoing-ovarian-stimulation-for-fertility-preservation
#7
Nigel Pereira, Amelia G Kelly, Logan D Stone, Justine D Witzke, Jovana P Lekovich, Rony T Elias, Glenn L Schattman, Zev Rosenwaks
OBJECTIVE: To compare the oocyte and embryo yield associated with GnRH-agonist triggers vs. hCG triggers in cancer patients undergoing controlled ovarian stimulation (COS) for fertilization preservation. DESIGN: Retrospective cohort study. SETTING: Academic center. PATIENT(S): Cancer patients undergoing COS with letrozole and gonadotropins or gonadotropin-only protocols for oocyte or embryo cryopreservation. INTERVENTION(S): Gonadotropin-releasing hormone agonist or hCG trigger...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28837025/comparison-of-two-different-dosage-of-gnrh-agonist-as-ovulation-trigger-in-oocyte-donors-a-randomized-controled-trial
#8
Sonia Morales Zarcos, Pamela Valdivieso Mejía, Carla Donado Stefani, Pascual Sánchez Martin, Fernando Sánchez Martin
OBJECTIVE: To compare the results obtained with two different GnRH agonist dosages: 0.3mg versus 0.4mg to trigger ovulation in oocyte donor cycles. METHODS: Experimental controlled randomized trial including 40 patients from a private practice center. The patients were randomized into two groups. Group A received a single dose of Triptorelin 0.3mg (Decapeptyl®) 36hours before pick-up. Group B patients received Triptorelin 0.4mg (Decapeptyl®) before pick-up to final oocyte maturation...
September 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28830648/feasibility-of-corifollitropin-alfa-gnrh-antagonist-protocol-combined-with-gnrh-agonist-triggering-and-freeze-all-strategy-in-polycystic-ovary-syndrome-patients
#9
Jiann-Loung Hwang, Shee-Uan Chen, Hen-Ju Chen, Hsin-Fu Chen, Yu-Shih Yang, Chin-Hao Chang, Kok-Min Seow, Chii-Ruey Tzeng, Yu-Hung Lin
BACKGROUND/PURPOSE: The long-acting corifollitropin alfa is comparable to FSH in terms of pregnancy outcomes in normal responders and poor responders. Corifollitropin alfa has never been studied in polycystic ovary syndrome (PCOS) patients because of concerns of excessive ovarian stimulation and ovarian hyperstimulation syndrome (OHSS). The purpose of the study was to evaluate if corifollitropin alfa can be used in PCOS patients. METHODS: Forty PCOS patients who were going to undergo in vitro fertilization were enrolled in this study...
August 19, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28760794/comparison-of-a-freeze-all-strategy-including-gnrh-agonist-trigger-versus-a-fresh-transfer-strategy-including-hcg-trigger-in-assisted-reproductive-technology-art-a-study-protocol-for-a-randomised-controlled-trial
#10
Sacha Stormlund, Kristine Løssl, Anne Zedeler, Jeanette Bogstad, Lisbeth Prætorius, Henriette Svarre Nielsen, Mona Bungum, Sven O Skouby, Anne Lis Mikkelsen, Anders Nyboe Andersen, Christina Bergh, Peter Humaidan, Anja Pinborg
INTRODUCTION: Pregnancy rates after frozen embryo transfer (FET) have improved in recent years and are now approaching or even exceeding those obtained after fresh embryo transfer. This is partly due to improved laboratory techniques, but may also be caused by a more physiological hormonal and endometrial environment in FET cycles. Furthermore, the risk of ovarian hyperstimulation syndrome is practically eliminated in segmentation cycles followed by FET and the use of natural cycles in FETs may be beneficial for the postimplantational conditions of fetal development...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28742191/high-progesterone-levels-during-the-luteal-phase-related-to-the-use-of-an-aromatase-inhibitor-in-breast-cancer-patients
#11
C Alviggi, R Marci, R Vallone, A Conforti, F Di Rella, I Strina, S Picarelli, P De Rosa, M De Laurentiis, C Yding Andersen, G De Placido
OBJECTIVE: To evaluate the hormonal profile in three breast cancer patients who underwent controlled ovarian stimulation in the presence of the aromatase inhibitor letrozole. PATIENTS AND METHODS: In IVF University referral center, a case series of three breast cancer patients who underwent controlled ovarian stimulation (COS) with recombinant FSH and letrozole were investigated. Ovulation was induced with hCG (case No. 1) or with GnRH agonist (case No. 2-3). The primary outcome of our study was the detection of progesterone levels in the luteal phase...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28715965/dual-triggering-with-gonadotropin-releasing-hormone-agonist-and-standard-dose-human-chorionic-gonadotropin-in-patients-with-a-high-immature-oocyte-rate
#12
Alberta Maria Fabris, M Cruz, V Legidos, C Iglesias, M Muñoz, J A García-Velasco
In in vitro fertilization (IVF) cycles, some patients show a high rate of immature oocytes retrieved after controlled ovarian stimulation. In vitro oocyte maturation is an experimental technique, with poorer results than conventional IVF. For this reason, improving in vivo maturation could meliorate the reproductive outcome of these patients. We performed a retrospective, not interventional, study analyzing the difference in the number and percentage of mature oocytes retrieved in patients with more than 50% immature oocytes in a previous IVF cycle triggered with human chorionic gonadotropin (hCG) compared to the number and rate of mature oocytes retrieved in subsequent cycles, triggered with both gonadotropin-releasing hormone agonist (GnRH-a) and hCG...
August 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28710674/what-is-the-best-predictor-of-severe-ovarian-hyperstimulation-syndrome-in-ivf-a-cohort-study
#13
Theoni B Tarlatzi, Christos A Venetis, Fabienne Devreker, Yvon Englert, Anne Delbaere
PURPOSE: The purpose of the present study is to study what is the best predictor of severe ovarian hyperstimulation syndrome (OHSS) in IVF. METHODS: This is a retrospective analysis of all consecutive IVF/intracytoplasmic injection cycles performed during a 5-year period (2009-2014) in a single university fertility centre. All fresh IVF cycles where ovarian stimulation was performed with gonadotrophins and GnRH agonists or antagonists and triggering of final oocyte maturation was induced with the administration of urinary or recombinant hCG were analyzed (2982 patients undergoing 5493 cycles)...
October 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28697910/duphaston-and-human-menopausal-gonadotropin-protocol-in-normally-ovulatory-women-undergoing-controlled-ovarian-hyperstimulation-during-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection-treatments-in-combination-with-embryo-cryopreservation
#14
RANDOMIZED CONTROLLED TRIAL
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
OBJECTIVE: To evaluate endocrine characteristics and clinical outcomes in normal ovulatory patients undergoing controlled ovarian hyperstimulation (COH) with the use of a Duphaston and hMG protocol during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments in combination with frozen-thawed embryo transfer (FET) compared with the characteristics and outcomes of patients undergoing an Utrogestan and hMG protocol. DESIGN: Prospective controlled study...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28663739/impact-of-mid-luteal-phase-gnrh-agonist-administration-on-reproductive-outcomes-in-gnrh-agonist-triggered-cycles-a-randomized-controlled-trial
#15
Abdelhamid Benmachiche, Sebti Benbouhedja, Abdelali Zoghmar, Amel Boularak, Peter Humaidan
OBJECTIVE: To explore whether the addition of a mid-luteal bolus of GnRH agonist (GnRHa) improves the implantation rate (IR) in in vitro fertilization (IVF) cycles. DESIGN: A randomized controlled trial. SETTING: Private IVF center. PATIENTS: 328 IVF/intracytoplasmic sperm injection patients were triggered with GnRHa and received 1,500 IU HCG on the day of oocyte pick-up (OPU) in addition to a standard luteal phase support (LPS)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28649232/ion-channels-of-pituitary-gonadotrophs-and-their-roles-in-signaling-and-secretion
#16
REVIEW
Stanko S Stojilkovic, Ivana Bjelobaba, Hana Zemkova
Gonadotrophs are basophilic cells of the anterior pituitary gland specialized to secrete gonadotropins in response to elevation in intracellular calcium concentration. These cells fire action potentials (APs) spontaneously, coupled with voltage-gated calcium influx of insufficient amplitude to trigger gonadotropin release. The spontaneous excitability of gonadotrophs reflects the expression of voltage-gated sodium, calcium, potassium, non-selective cation-conducting, and chloride channels at their plasma membrane (PM)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28638367/gnrh-agonist-trigger-and-lh-activity-luteal-phase-support-versus-hcg-trigger-and-conventional-luteal-phase-support-in-fresh-embryo-transfer-ivf-icsi-cycles-a-systematic-prisma-review-and-meta-analysis
#17
REVIEW
Thor Haahr, Matheus Roque, Sandro C Esteves, Peter Humaidan
INTRODUCTION: The use of GnRH agonist (GnRHa) for final oocyte maturation trigger in oocyte donation and elective frozen embryo transfer cycles is well established due to lower ovarian hyperstimulation syndrome (OHSS) rates as compared to hCG trigger. A recent Cochrane meta-analysis concluded that GnRHa trigger was associated with reduced live birth rates (LBRs) in fresh autologous IVF cycles compared to hCG trigger. However, the evidence is not unequivocal, and recent trials have found encouraging reproductive outcomes among couples undergoing GnRHa trigger and individualized luteal LH activity support...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28625761/impact-of-vitamin-d-levels-on-ovarian-reserve-and-ovarian-response-to-ovarian-stimulation-in-oocyte-donors
#18
Alberta Maria Fabris, Maria Cruz, Carlos Iglesias, Alberto Pacheco, Azadeh Patel, Jayesh Patel, Human Fatemi, Juan Antonio García-Velasco
Recently, growing interest in vitamin D has emerged from findings that demonstrate a low vitamin D status in populations. Similarly, much interest has been shown in the role that anti-Müllerian hormone (AMH) plays in reproductive physiology. Considerable confusion as to whether vitamin D status is related to ovarian function can be found in the literature. Our retrospective study was performed from June 2014 to April 2015. Oocyte donors were recruited and stimulated under the antagonist protocol with gonadotrophin-releasing hormone (GnRH) agonist to trigger ovulation...
May 19, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28601880/accelerated-coasting-does-not-affect-oocyte-maturation
#19
Ahmed F Galal, Hadeer Aly Abbassy, Ashraf Hany AbdElrahman, Mohamed Sayed Abdelhafez, Ahmed Badawy
AIMS: The study aimed to assess the efficacy of accelerating the process of coasting through adding gonadotropin releasing hormone (GnRH) antagonist (GnRH-ant) on the day of triggering of oocyte maturation without withholding the GnRH agonist (GnRHa) in women at risk for developing ovarian hyperstimulation syndrome (OHSS). METHODS: Retrospective case-control study of the outcomes of GnRHa cycles in which women were at risk to develop OHSS. Women who underwent acceleration of coasting (n = 50) were compared with a control group of women who underwent usual coasting (n = 57)...
June 10, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28600619/ovarian-hyperstimulation-syndrome-following-gnrh-agonist-trigger-think-ectopic
#20
Raoul Orvieto, Valeria Stella Vanni
PURPOSE: This study aims to report a case of ovarian hyperstimulation syndrome (OHSS) following GnRH agonist trigger for final follicular maturation. METHODS: This study is a retrospective chart review. RESULTS: We report the first case of OHSS following GnRH agonist trigger for final follicular maturation and freeze-all, masking extrauterine pregnancy (EUP). The present case report elucidates the feasibility of stimulating and recruiting ovarian follicles yielding mature oocytes during early pregnancy and the ability of GnRH agonist to trigger final follicular maturation during pregnancy, in the presence of high progesterone and hCG levels...
June 9, 2017: Journal of Assisted Reproduction and Genetics
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