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https://www.readbyqxmd.com/read/27936287/combining-item-response-theory-with-multiple-imputation-to-equate-health-assessment-questionnaires
#1
Chenyang Gu, Roee Gutman
The assessment of patients' functional status across the continuum of care requires a common patient assessment tool. However, assessment tools that are used in various health care settings differ and cannot be easily contrasted. For example, the Functional Independence Measure (FIM) is used to evaluate the functional status of patients who stay in inpatient rehabilitation facilities, the Minimum Data Set (MDS) is collected for all patients who stay in skilled nursing facilities, and the Outcome and Assessment Information Set (OASIS) is collected if they choose home health care provided by home health agencies...
December 9, 2016: Biometrics
https://www.readbyqxmd.com/read/27931207/a-comparative-study-classification-vs-user-based-collaborative-filtering-for-clinical-prediction
#2
Fang Hao, Rachael Hageman Blair
BACKGROUND: Recommender systems have shown tremendous value for the prediction of personalized item recommendations for individuals in a variety of settings (e.g., marketing, e-commerce, etc.). User-based collaborative filtering is a popular recommender system, which leverages an individuals' prior satisfaction with items, as well as the satisfaction of individuals that are "similar". Recently, there have been applications of collaborative filtering based recommender systems for clinical risk prediction...
December 8, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27931187/computational-strategies-for-alternative-single-step-bayesian-regression-models-with-large-numbers-of-genotyped-and-non-genotyped-animals
#3
Rohan L Fernando, Hao Cheng, Bruce L Golden, Dorian J Garrick
BACKGROUND: Two types of models have been used for single-step genomic prediction and genome-wide association studies that include phenotypes from both genotyped animals and their non-genotyped relatives. The two types are breeding value models (BVM) that fit breeding values explicitly and marker effects models (MEM) that express the breeding values in terms of the effects of observed or imputed genotypes. MEM can accommodate a wider class of analyses, including variable selection or mixture model analyses...
December 8, 2016: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/27925597/tackling-missing-data-in-community-health-studies-using-additive-ls-svm-classifier
#4
Guanjin Wang, Zhaohong Deng, Kup-Sze Choi
Missing data is a common issue in community health and epidemiological studies. Direct removal of samples with missing data can lead to reduced sample size and information bias, which deteriorates the significance of the results. While data imputation methods are available to deal with missing data, they are limited in performance and could introduce noises into the dataset. Instead of data imputation, a novel method based on additive least square support vector machine (LS-SVM) is proposed in this paper for predictive modeling when the input features of the model contain missing data...
December 1, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27923414/missing-data-in-ffqs-making-assumptions-about-item-non-response
#5
Karen E Lamb, Dana Lee Olstad, Cattram Nguyen, Catherine Milte, Sarah A McNaughton
OBJECTIVE: FFQs are a popular method of capturing dietary information in epidemiological studies and may be used to derive dietary exposures such as nutrient intake or overall dietary patterns and diet quality. As FFQs can involve large numbers of questions, participants may fail to respond to all questions, leaving researchers to decide how to deal with missing data when deriving intake measures. The aim of the present commentary is to discuss the current practice for dealing with item non-response in FFQs and to propose a research agenda for reporting and handling missing data in FFQs...
December 7, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27921338/melancholic-and-atypical-depression-as-predictor-and-moderator-of-outcome-in-cognitive-behavior-therapy-and-pharmacotherapy-for-adult-depression
#6
Pim Cuijpers, Erica Weitz, Femke Lamers, Brenda W Penninx, Jos Twisk, Robert J DeRubeis, Sona Dimidjian, Boadie W Dunlop, Robin B Jarrett, Zindel V Segal, Steven D Hollon
BACKGROUND: Melancholic and atypical depression are widely thought to moderate or predict outcome of pharmacological and psychological treatments of adult depression, but that has not yet been established. This study uses the data from four earlier trials comparing cognitive behavior therapy (CBT) versus antidepressant medications (ADMs; and pill placebo when available) to examine the extent to which melancholic and atypical depression moderate or predict outcome in an "individual patient data" meta-analysis...
December 6, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27921315/imputing-estrogen-receptor-er-status-in-a-population-based-cancer-registry-a-sensitivity-analysis
#7
Rebecca Andridge, Anne-Michelle Noone, Nadia Howlader
Breast cancers are clinically heterogeneous based on tumor markers. The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program provides baseline data on these tumor markers for reporting cancer burden and trends over time in the US general population. These tumor markers, however, are often prone to missing observations. In particular, estrogen receptor (ER) status, a key biomarker in the study of breast cancer, has been collected since 1992 but historically was not well-reported, with missingness rates as high as 25% in early years...
December 5, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27919261/caf%C3%A3-a-multicomponent-audit-and-feedback-intervention-to-improve-implementation-of-healthy-food-policy-in-primary-school-canteens-a-randomised-controlled-trial
#8
Sze Lin Yoong, Nicole Nathan, Luke Wolfenden, John Wiggers, Kathryn Reilly, Christopher Oldmeadow, Rebecca Wyse, Rachel Sutherland, Tessa Delaney, Peter Butler, Lisa Janssen, Sarah Preece, Christopher M Williams
BACKGROUND: The implementation of nutrition policies in schools has been recommended as a strategy to improve child dietary intake. Internationally, research suggests that the majority of schools do not implement these policies. In New South Wales (NSW), Australia, the NSW Healthy School Canteen Policy requires that school canteens prohibit the sale of 'red' foods (i.e. foods that are typically nutrient poor and high in energy, such as confectionary and deep-fried foods) and 'banned'drinks (i...
December 5, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27919231/erratum-to-assessment-of-predictive-performance-in-incomplete-data-by-combining-internal-validation-and-multiple-imputation
#9
Simone Wahl, Anne-Laure Boulesteix, Astrid Zierer, Barbara Thorand, Mark A van de Wiel
No abstract text is available yet for this article.
December 5, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27918712/cost-utility-of-stepped-care-targeting-psychological-distress-in-patients-with-head-and-neck-or-lung-cancer
#10
Femke Jansen, Anna M H Krebber, Veerle M H Coupé, Pim Cuijpers, Remco de Bree, Annemarie Becker-Commissaris, Egbert F Smit, Annemieke van Straten, Guus M Eeckhout, Aartjan T F Beekman, C René Leemans, Irma M Verdonck-de Leeuw
Purpose A stepped care (SC) program in which an effective yet least resource-intensive treatment is delivered to patients first and followed, when necessary, by more resource-intensive treatments was found to be effective in improving distress levels of patients with head and neck cancer or lung cancer. Information on the value of this program for its cost is now called for. Therefore, this study aimed to assess the cost-utility of the SC program compared with care-as-usual (CAU) in patients with head and neck cancer or lung cancer who have psychological distress...
December 5, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27911851/inherited-variants-affecting-rna-editing-may-contribute-to-ovarian-cancer-susceptibility-results-from-a-large-scale-collaboration
#11
Jennifer B Permuth, Brett Reid, Madalene Earp, Y Ann Chen, Alvaro N A Monteiro, Zhihua Chen, Aocs Study Group, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Adriaan Vanderstichele, Els Van Niewenhuyse, Ignace Vergote, Mary Anne Rossing, Jennifer Anne Doherty, Jenny Chang-Claude, Kirsten Moysich, Kunle Odunsi, Marc T Goodman, Yurii B Shvetsov, Lynne R Wilkens, Pamela J Thompson, Thilo Dörk, Natalia Bogdanova, Ralf Butzow, Heli Nevanlinna, Liisa Pelttari, Arto Leminen, Francesmary Modugno, Robert P Edwards, Roberta B Ness, Joseph Kelley, Florian Heitz, Beth Karlan, Jenny Lester, Susanne K Kjaer, Allan Jensen, Graham Giles, Michelle Hildebrandt, Dong Liang, Karen H Lu, Xifeng Wu, Douglas A Levine, Maria Bisogna, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Shelley S Tworoger, Elizabeth M Poole, Elisa V Bandera, Brooke Fridley, Julie Cunningham, Stacey J Winham, Sara H Olson, Irene Orlow, Line Bjorge, Lambertus A Kiemeney, Leon Massuger, Tanja Pejovic, Melissa Moffitt, Nhu Le, Linda S Cook, Angela Brooks-Wilson, Linda E Kelemen, Jacek Gronwald, Jan Lubinski, Nicolas Wentzensen, Louise A Brinton, Jolanta Lissowska, Hanna Yang, Estrid Hogdall, Claus Hogdall, Lene Lundvall, Paul D P Pharoah, Honglin Song, Ian Campbell, Diana Eccles, Iain McNeish, Alice Whittemore, Valerie McGuire, Weiva Sieh, Joseph Rothstein, Catherine M Phelan, Harvey Risch, Steven Narod, John McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Celeste Leigh Pearce, Anna H Wu, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Joellen M Schildkraut, Jin Q Cheng, Ellen L Goode, Thomas A Sellers
RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypothesized that single nucleotide polymorphisms (SNPs) in ADAR genes modify EOC susceptibility, potentially by altering ovarian tissue gene expression. Using directly genotyped and imputed data from 10,891 invasive EOC cases and 21,693 controls, we evaluated the associations of 5,303 SNPs in ADAD1, ADAR, ADAR2, ADAR3, and SND1...
July 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27910156/ixekizumab-treatment-improves-fingernail-psoriasis-in-patients-with-moderate-to-severe-psoriasis-results-from-the-randomized-controlled-and-open-label-phases-of-uncover-3
#12
P van de Kerkhof, L Guenther, A B Gottlieb, M Sebastian, J J Wu, P Foley, A Morita, O Goldblum, L Zhang, J Erickson, S Ball, P Rich
BACKGROUND: Fingernail psoriasis is difficult to treat. OBJECTIVE: The objective was to evaluate the effect of ixekizumab, a monoclonal antibody selectively targeting IL-17A, on fingernail psoriasis. METHODS: This Phase 3, double-blind trial (UNCOVER-3) randomized patients to placebo, etanercept (50-mg twice weekly), or 80 mg ixekizumab as one injection every 4 (IXE Q4W) or 2 weeks (IXE Q2W) after a 160-mg starting dose. At Week 12, ixekizumab patients received open-label IXE Q4W through Week 60; placebo patients received a 160-mg starting ixekizumab dose and etanercept patients a 4-week placebo washout before starting IXE Q4W...
November 5, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27909221/factors-related-to-diffuse-large-b-cell-lymphoma-relative-survival-in-a-population-based-study-in-france-is-there-a-role-of-socio-economic-status
#13
Sandra Le Guyader-Peyrou, Sebastien Orazio, Olivier Dejardin, Marc Maynadie, Xavier Troussard, Alain Monnereau
Due to addition of anti-CD20 to anthracycline-based chemotherapy, survival of diffuse large B-cell lymphoma increased during the last decade. Although these trends are encouraging, there are still persistent differences in survival within and between US and European countries suggesting the role of non-biological factors. Our aim was to investigate the influence of such factors on relative survival of diffuse large B-cell lymphoma patients. We conducted a retrospective multicenter registry-based study in France, between 2002 and 2008, on 1165 incident cases of diffuse large B-cell lymphoma Relative survival analyses were performed and data missing were controlled with multiple imputation method...
December 1, 2016: Haematologica
https://www.readbyqxmd.com/read/27909127/costs-quality-of-life-and-cost-effectiveness-of-arthroscopic-and-open-repair-for-rotator-cuff-tears-an-economic-evaluation-alongside-the-ukuff-trial
#14
J Murphy, A Gray, C Cooper, D Cooper, C Ramsay, A Carr
AIMS: A trial-based comparison of the use of resources, costs and quality of life outcomes of arthroscopic and open surgical management for rotator cuff tears in the United Kingdom NHS was performed using data from the United Kingdom Rotator Cuff Study (UKUFF) randomised controlled trial. PATIENTS AND METHODS: Using data from 273 patients, healthcare-related use of resources, costs and quality-adjusted life years (QALYs) were estimated at 12 months and 24 months after surgery on an intention-to-treat basis with adjustment for covariates...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27905878/genomic-prediction-using-preselected-dna-variants-from-a-gwas-with-whole-genome-sequence-data-in-holstein-friesian-cattle
#15
Roel F Veerkamp, Aniek C Bouwman, Chris Schrooten, Mario P L Calus
BACKGROUND: Whole-genome sequence data is expected to capture genetic variation more completely than common genotyping panels. Our objective was to compare the proportion of variance explained and the accuracy of genomic prediction by using imputed sequence data or preselected SNPs from a genome-wide association study (GWAS) with imputed whole-genome sequence data. METHODS: Phenotypes were available for 5503 Holstein-Friesian bulls. Genotypes were imputed up to whole-genome sequence (13,789,029 segregating DNA variants) by using run 4 of the 1000 bull genomes project...
December 1, 2016: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/27902717/could-google-trends-be-used-to-predict-methamphetamine-related-crime-an-analysis-of-search-volume-data-in-switzerland-germany-and-austria
#16
Alex Gamma, Roman Schleifer, Wolfgang Weinmann, Anna Buadze, Michael Liebrenz
OBJECTIVE: To compare the time trends of Google search interest in methamphetamine and criminal offences related to this drug. METHODS: Google Trends data for the search term "meth" was compared to methamphetamine-related crime statistics (incl. use, possession, and dealing) in Switzerland, Germany, and Austria for the years 2004-2016. Google data was availably monthly. Crime data was available yearly, and monthly values were imputed. RESULTS: On the country level, internet search trends for "meth" roughly paralleled relevant criminal activity...
2016: PloS One
https://www.readbyqxmd.com/read/27900064/enzalutamide-induced-acute-generalized-exanthematous-pustulosis
#17
Chloé Alberto, Maria Polina Konstantinou, Catherine Martinage, Eline Casassa, Emilie Tournier, Haleh Bagheri, Vincent Sibaud, Loïc Mourey, Juliette Mazereeuw-Hautier, Nicolas Meyer, Carle Paul, Cristina Bulai Livideanu
INTRODUCTION: Enzalutamide (Xtandi®) is a new potent inhibitor of the signaling pathway for the androgen receptor with a half-life of 5.8 days. It has been on the market for the treatment of metastatic castration-resistant prostate cancer since November 2013. OBJECTIVE: We report the first case of acute generalized exanthematous pustulosis (AGEP) induced by enzalutamide. OBSERVATION: A 62-year-old male patient with no significant medical history, was diagnosed in April 2014 with metastatic prostatic adenocarcinoma...
November 13, 2016: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/27898963/justification-for-setting-the-individual-animal-genotype-call-rate-threshold-at-eighty-five-percent
#18
D C Purfield, M McClure, D P Berry
Data quality of SNP arrays impacts the accuracy and precision of downstream data analyses. One such quality control measure often imposed is a threshold on individual animal call rate. Different call rate thresholds have been applied across studies; little is known, however, about the impact of these thresholds on the quality of the genotype data. The objective of the present study was to investigate the effect of different call rate thresholds on the integrity of the genotypes but also to quantify the contribution of different factors to the variability in animal call rate...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898706/prediction-of-body-mass-index-using-concurrently-self-reported-or-previously-measured-height-and-weight
#19
Zhaohui Cui, June Stevens, Kimberly P Truesdale, Donglin Zeng, Simone French, Penny Gordon-Larsen
OBJECTIVE: To compare alternative models for the imputation of BMIM (measured weight in kilograms/measured height in meters squared) in a longitudinal study. METHODS: We used data from 11,008 adults examined at wave III (2001-2002) and wave IV (2007-2008) in the National Longitudinal Study of Adolescent to Adult Health. Participants were asked their height and weight before being measured. Equations to predict wave IV BMIM were developed in an 80% random subsample and evaluated in the remaining participants...
2016: PloS One
https://www.readbyqxmd.com/read/27897266/evaluation-of-association-of-common-variants-in-htr1a-and-htr5a-with-schizophrenia-and-executive-function
#20
Fanglin Guan, Huali Lin, Gang Chen, Lu Li, Teng Chen, Xinshe Liu, Jiuqiang Han, Tao Li
The 5-HT1A receptor (HTR1A) and the 5-HT5A receptor (HTR5A) are key 5-HT receptors with distinct inhibitory functions. Studies have been conducted to investigate the association of a few HTR1A polymorphisms with schizophrenia, producing conflicting results, and the relationship between HTR5A and schizophrenia has not yet been well investigated. We aimed to examine the association of HTR1A and HTR5A with schizophrenia and executive function. The study included a discovery stage with 1,115 patients and 2,289 controls and a replication stage with 2,128 patients and 3,865 controls...
November 29, 2016: Scientific Reports
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