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https://www.readbyqxmd.com/read/28806775/depression-screening-with-patient-targeted-feedback-in-cardiology-the-cost-effectiveness-of-depscreen-info
#1
Christian Brettschneider, Sebastian Kohlmann, Benjamin Gierk, Bernd Löwe, Hans-Helmut König
BACKGROUND: Although depression is common in patients with heart disease, screening for depression is much debated. DEPSCREEN-INFO showed that a patient-targeted feedback in addition to screening results in lower depression level six months after screening. The purpose of this analysis was to perform a cost-effectiveness analysis of DEPSCREEN-INFO. METHODS: Patients with coronary heart disease or arterial hypertension were included. Participants in both groups were screened for depression...
2017: PloS One
https://www.readbyqxmd.com/read/28805929/the-impact-of-training-strategies-on-the-accuracy-of-genomic-predictors-in-united-states-red-angus-cattle
#2
J Lee, S D Kachman, M L Spangler
Genomic selection (GS) has become an integral part of genetic evaluation methodology and has been applied to all major livestock species, including beef and dairy cattle, pigs, and chickens. Significant contributions in increased accuracy of selection decisions have been clearly illustrated in dairy cattle after practical application of GS. In the majority of U.S. beef cattle breeds, similar efforts have also been made to increase the accuracy of genetic merit estimates through the inclusion of genomic information into routine genetic evaluations using a variety of methods...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805909/genomewide-association-study-for-production-and-meat-quality-traits-in-canchim-beef-cattle
#3
G G Santiago, F Siqueira, F F Cardoso, L C A Regitano, R Ventura, B P Sollero, M D Souza, F B Mokry, A B R Ferreira, R A A Torres
The commercial value of the bovine carcass is determined by a set of traits, such as weight, yield, back fat thickness, and marbling; therefore, the genetic improvement of growth, meat, and carcass quality traits is an important tool to add value to the supply chain. Genomewide association studies (GWAS) enable the identification of loci that control phenotypic expression of quantitative traits (QTL). Therefore, the objective of this work was to perform a GWAS to identify genomic regions and genes associated with growth, carcass traits, and meat quality in Canchim beef cattle...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805813/analysis-of-genome-wide-association-data-highlights-candidates-for-drug-repositioning-in-psychiatry
#4
Hon-Cheong So, Carlos Kwan-Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim, Pak-Chung Sham
Knowledge of psychiatric disease genetics has advanced rapidly during the past decade with the advent of genome-wide association studies (GWAS). However, less progress has been made in harnessing these data to reveal new therapies. Here we propose a framework for drug repositioning by comparing transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectivity Map database and apply this approach to seven psychiatric disorders. We found a number of repositioning candidates, many supported by preclinical or clinical evidence...
August 14, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28802878/prehospital-sodium-bicarbonate-use-could-worsen-long-term-survival-with-favorable-neurological-recovery-among-patients-with-out-of-hospital-cardiac-arrest
#5
Takahisa Kawano, Brian Grunau, Frank X Scheuermeyer, Koichiro Gibo, William Dick, Christopher B Fordyce, Paul Dorian, Robert Stenstrom, Ronald Straight, Jim Christenson
BACKGROUND: Sodium bicarbonate (SB) is widely used for resuscitation in out-of- hospital cardiac arrest (OHCA); however, its effect on long term outcomes is unclear. METHODS: From 2005 to 2016, we prospectively conducted a province-wide population-based observational study including adult non-traumatic OHCA patients managed by paramedics. SB was administered by paramedics based on their clinical assessments. To examine the association of SB administration and survival and favorable neurological outcome to hospital discharge, defined as modified Rankin scale of 3 or less, we performed a multivariable logistic regression analysis: (1) within propensity score matched comparison groups, and; (2) within the full cohort with missing variables addressed by multiple imputation techniques...
August 9, 2017: Resuscitation
https://www.readbyqxmd.com/read/28802542/the-impact-of-intravenous-alteplase-on-long-term-patient-survival-the-georgia-coverdell-acute-stroke-registry-s-experience
#6
Moges S Ido, Michael R Frankel, Ike S Okosun, Richard B Rothenberg
INTRODUCTION: Intravenous alteplase reduces disability and improves functionality among acute ischemic stroke patients. Two decades after its approval, only a small fraction of patients get the treatment, and demonstrating its impact on mortality may make a strong case for its wider use. This study assessed the impact of thrombolytic treatment by alteplase on 1-year mortality and readmission among acute ischemic stroke patients. METHOD: The 2008-2013 Georgia Coverdell Acute Stroke Registry data were linked with the 2008-2013 hospital discharge and the 2008-2014 death data in Georgia...
July 31, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28800727/a-phased-snp-based-classification-of-sickle-cell-anemia-hbb-haplotypes
#7
Elmutaz M Shaikho, John J Farrell, Abdulrahman Alsultan, Hatem Qutub, Amein K Al-Ali, Maria Stella Figueiredo, David H K Chui, Lindsay A Farrer, George J Murphy, Gustavo Mostoslavsky, Paola Sebastiani, Martin H Steinberg
BACKGROUND: Sickle cell anemia causes severe complications and premature death. Five common β-globin gene cluster haplotypes are each associated with characteristic fetal hemoglobin (HbF) levels. As HbF is the major modulator of disease severity, classifying patients according to haplotype is useful. The first method of haplotype classification used restriction fragment length polymorphisms (RFLPs) to detect single nucleotide polymorphisms (SNPs) in the β-globin gene cluster. This is labor intensive, and error prone...
August 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28800628/genome-wide-analysis-of-sotalol-induced-ikr-inhibition-during-ventricular-repolarization-generepol-study-lack-of-common-variants-with-large-effect-sizes
#8
Joe-Elie Salem, Marine Germain, Jean-Sébastien Hulot, Pascal Voiriot, Bruno Lebourgeois, Jean Waldura, David-Alexandre Tregouet, Beny Charbit, Christian Funck-Brentano
Many drugs used for non-cardiovascular and cardiovascular purposes, such as sotalol, have the side effect of prolonging cardiac repolarization, which can trigger life-threatening cardiac arrhythmias by inhibiting the potassium-channel IKr (KCNH2). On the electrocardiogram (ECG), IKr inhibition induces an increase in QTc and Tpeak-Tend (TpTe) interval and a decrease of T wave maximal amplitude (TAmp). These changes vary markedly between subjects, suggesting the existence of predisposing genetic factors. 990 healthy individuals, prospectively challenged with an oral 80mg sotalol dose, were monitored for changes in ventricular repolarization on ECG between baseline and 3 hours post dosing...
2017: PloS One
https://www.readbyqxmd.com/read/28799431/vulvar-cancer-in-germany-increase-in-incidence-and-change-in-tumour-biological-characteristics-from-1974-to-2013
#9
Bernd Holleczek, Jalid Sehouli, Jana Barinoff
BACKGROUND: The incidence of vulvar cancer in Germany is increasing. Moreover, gynaecological oncologists reported observing increasing numbers of women presenting with small tumours. The aim of the present study is to validate this observation on a population level and to extend available incidence data. MATERIAL AND METHODS: Data from the population-based Saarland Cancer Registry were used and included 1136 women diagnosed with invasive vulvar cancer (ICD-9 codes: 181...
August 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28799197/cost-effectiveness-of-the-family-nurse-partnership-fnp-programme-in-england-evidence-from-the-building-blocks-trial
#10
Belen Corbacho, Kerry Bell, Eugena Stamuli, Gerry Richardson, Sarah Ronaldson, Kerenza Hood, Julia Sanders, Michael Robling, David Torgerson
RATIONAL, AIMS, AND OBJECTIVES: The Family Nurse Partnership (FNP) is a licensed intensive home visiting intervention developed in the United States. It has been provided in England by the Department of Health since 2006. The Building Blocks trial assessed the effectiveness and cost-effectiveness of FNP in England. METHODS: We performed a cost-utility analysis (National Health Service (NHS) perspective) alongside the Building Blocks trial (over 2.5 y). The analysis was conducted in accordance with National Institute for Health and Clinical Excellence (NICE) reference case standards...
August 11, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28797652/geographic-variation-in-opioid-and-heroin-involved-drug-poisoning-mortality-rates
#11
Christopher J Ruhm
INTRODUCTION: An important barrier to formulating effective policies to address the rapid rise in U.S. fatal overdoses is that the specific drugs involved are frequently not identified on death certificates. This analysis supplies improved estimates of state opioid and heroin involved drug fatality rates in 2014, and changes from 2008 to 2014. METHODS: Reported mortality rates were calculated directly from death certificates and compared to corrected rates that imputed drug involvement when no drug was specified...
August 1, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28797326/severe-liver-disease-related-to-chronic-hepatitis-c-virus-infection-in-treatment-naive-patients-epidemiological-characteristics-and-associated-factors-at-first-expert-centre-visit-france-2000-to-2007-and-2010-to-2014
#12
Alice Sanna, Yann Le Strat, Françoise Roudot-Thoraval, Sylvie Deuffic Burban, Patrizia Carrieri, Elisabeth Delarocque-Astagneau, Christine Larsen
Given recent profound improvements in the effectiveness of antiviral treatment for chronic Hepatitis C virus (HCV) infection, we aimed to describe the characteristics of patients referred to hepatology expert centres in France from 2000 to 2007 and from 2010 to 2014, and to identify factors associated with severe liver disease at their first visit for evaluation. We analysed data from two sources covering all of France: the former hepatitis C surveillance network, which included patients between 2000 and 2007, and the ANRS CO22 HEPATHER multi-centre cohort, which included patients between 2012 and 2014...
July 27, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797230/use-of-biological-priors-enhances-understanding-of-genetic-architecture-and-genomic-prediction-of-complex-traits-within-and-between-dairy-cattle-breeds
#13
Lingzhao Fang, Goutam Sahana, Peipei Ma, Guosheng Su, Ying Yu, Shengli Zhang, Mogens Sandø Lund, Peter Sørensen
BACKGROUND: A better understanding of the genetic architecture underlying complex traits (e.g., the distribution of causal variants and their effects) may aid in the genomic prediction. Here, we hypothesized that the genomic variants of complex traits might be enriched in a subset of genomic regions defined by genes grouped on the basis of "Gene Ontology" (GO), and that incorporating this independent biological information into genomic prediction models might improve their predictive ability...
August 10, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28796626/matrix-and-tensor-completion-on-a-human-activity-recognition-framework
#14
Sofia Savvaki, Grigorios Tsagkatakis, Athanasia Panousopoulou, Panagiotis Tsakalides
Sensor-based activity recognition is encountered in innumerable applications of the arena of pervasive healthcare and plays a crucial role in biomedical research. Nonetheless, the frequent situation of unobserved measurements impairs the ability of machine learning algorithms to efficiently extract context from raw streams of data. In this work, we study the problem of accurate estimation of missing multi-modal inertial data and we propose a classification framework that considers the reconstruction of sub-sampled data during the test phase...
August 7, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28795654/association-between-circulating-leptin-levels-and-systemic-lupus-erythematosus-an-updated-meta-analysis
#15
Y H Lee, G G Song
Objective We aimed to evaluate the relationship between circulating leptin levels and systemic lupus erythematosus (SLE). Methods MEDLINE, EMBASE, and Cochrane library databases were searched. Meta-analyses were performed comparing serum/plasma leptin levels in patients with SLE and healthy controls, and on patients with SLE in subgroups based on ethnicity, sample size, data type, and matched variables (age, sex, and/or body mass index (BMI)). Results Eighteen studies including 1333 patients with SLE and 1048 controls were ultimately selected, which showed that leptin levels were significantly higher in the SLE group than in the control group (SMD = 0...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28794112/fifteen-genetic-loci-associated-with-the-electrocardiographic-p-wave
#16
Ingrid E Christophersen, Jared W Magnani, Xiaoyan Yin, John Barnard, Lu-Chen Weng, Dan E Arking, Maartje N Niemeijer, Steven A Lubitz, Christy L Avery, Qing Duan, Stephan B Felix, Joshua C Bis, Kathleen F Kerr, Aaron Isaacs, Martina Müller-Nurasyid, Christian Müller, Kari E North, Alex P Reiner, Lesley F Tinker, Jan A Kors, Alexander Teumer, Astrid Petersmann, Moritz F Sinner, Petra Buzkova, Jonathan D Smith, David R Van Wagoner, Uwe Völker, Melanie Waldenberger, Annette Peters, Thomas Meitinger, Marian C Limacher, Kirk C Wilhelmsen, Bruce M Psaty, Albert Hofman, Andre Uitterlinden, Bouwe P Krijthe, Zhu-Ming Zhang, Renate B Schnabel, Stefan Kääb, Cornelia van Duijn, Jerome I Rotter, Nona Sotoodehnia, Marcus Dörr, Yun Li, Mina K Chung, Elsayed Z Soliman, Alvaro Alonso, Eric A Whitsel, Bruno H Stricker, Emelia J Benjamin, Susan R Heckbert, Patrick T Ellinor
BACKGROUND: The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28791798/cost-effectiveness-analysis-of-potentially-curative-and-combination-treatments-for-hepatocellular-carcinoma-with-person-level-data-in-a-canadian-setting
#17
Hla-Hla Thein, Wanrudee Isaranuwatchai, Yao Qiao, Kenny Wong, Gonzalo Sapisochin, Kelvin K W Chan, Eric M Yoshida, Craig C Earle
Patients with early-stage hepatocellular carcinoma (HCC) are potential candidates for curative treatments such as radiofrequency ablation (RFA), surgical resection (SR), or liver transplantation (LT), which have demonstrated a significant survival benefit. We aimed to estimate the cost-effectiveness of curative and combination treatment strategies among patients diagnosed with HCC during 2002-2010. This study used Ontario Cancer Registry-linked administrative data to estimate effectiveness and costs (2013 USD) of the treatment strategies from the healthcare payer's perspective...
August 8, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28783884/a-pattern-mixture-model-approach-for-handling-missing-continuous-outcome-data-in-longitudinal-cluster-randomized-trials
#18
Mallorie H Fiero, Chiu-Hsieh Hsu, Melanie L Bell
We extend the pattern-mixture approach to handle missing continuous outcome data in longitudinal cluster randomized trials, which randomize groups of individuals to treatment arms, rather than the individuals themselves. Individuals who drop out at the same time point are grouped into the same dropout pattern. We approach extrapolation of the pattern-mixture model by applying multilevel multiple imputation, which imputes missing values while appropriately accounting for the hierarchical data structure found in cluster randomized trials...
August 7, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28780673/investigating-the-genetic-relationship-between-alzheimer-s-disease-and-cancer-using-gwas-summary-statistics
#19
Yen-Chen Anne Feng, Kelly Cho, Sara Lindstrom, Peter Kraft, Jean Cormack, Liming Liang, Jane A Driver
Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer's disease (AD) and cancer. We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP and GAME-ON consortia. Sample size ranged from 9931 to 54,162; SNPs were imputed to the 1000 Genomes European panel. Our results based on cross-trait LD Score regression showed a significant positive genetic correlation between AD and five cancers combined (colon, breast, prostate, ovarian, lung; r g = 0...
August 5, 2017: Human Genetics
https://www.readbyqxmd.com/read/28780587/genotyping-by-sequencing-highlights-original-diversity-patterns-within-a-european-collection-of-1191-maize-flint-lines-as-compared-to-the-maize-usda-genebank
#20
Brigitte Gouesnard, Sandra Negro, Amélie Laffray, Jeff Glaubitz, Albrecht Melchinger, Pedro Revilla, Jesus Moreno-Gonzalez, Delphine Madur, Valérie Combes, Christine Tollon-Cordet, Jacques Laborde, Dominique Kermarrec, Cyril Bauland, Laurence Moreau, Alain Charcosset, Stéphane Nicolas
Genotyping by sequencing is suitable for analysis of global diversity in maize. We showed the distinctiveness of flint maize inbred lines of interest to enrich the diversity of breeding programs. Genotyping-by-sequencing (GBS) is a highly cost-effective procedure that permits the analysis of large collections of inbred lines. We used it to characterize diversity in 1191 maize flint inbred lines from the INRA collection, the European Cornfed association panel, and lines recently derived from landraces. We analyzed the properties of GBS data obtained with different imputation methods, through comparison with a 50 K SNP array...
August 5, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
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