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Ileal pouch anal anastomosis

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https://www.readbyqxmd.com/read/29668894/endoscopic-treatment-of-ileal-pouch-sinus
#1
Nan Lan, Bo Shen
Background and aims: Pouch sinus is a serious complication in patients undergoing ileal pouch-anal anastomosis. The aim of this study was to verify the efficacy and safety of endoscopic needle knife sinusotomy (NKSi) in the management of pouch sinus. Methods: All consecutive patients with a pouch sinus treated with NKSi from 2008 to 2016 were identified. The primary outcomes were complete healing of the sinus and pouch survival. Results: A total of 109 patients were included...
April 12, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29660321/reliability-among-central-readers-in-the-evaluation-of-endoscopic-disease-activity-in-pouchitis
#2
Mark A Samaan, Bo Shen, Mahmoud H Mosli, Guangyong Zou, William J Sandborn, Lisa M Shackelton, Sigrid Nelson, Larry Stitt, Stuart Bloom, Darrell S Pardi, Paolo Gionchetti, James Lindsay, Simon Travis, Ailsa Hart, Mark S Silverberg, Brian G Feagan, Geert R D'Haens, Vipul Jairath
BACKGROUND & AIMS: Pouchitis is a common adverse event after proctocolectomy with ileal pouch anal anastomosis for ulcerative colitis. Evaluation of pouchitis disease activity and response to treatment requires use of validated indices. We assessed the reliability of items evaluating endoscopic pouchitis disease activity. METHODS: Twelve panelists used a modified RAND appropriateness methodology to rate the appropriateness of items evaluating endoscopic pouchitis disease activity derived from a systematic review, and also identified additional potential endoscopic items based on expert opinion...
April 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29650924/-endoscopy-assisted-partial-duodenal-resection-for-duodenal-adenoma-in-a-patient-with-familial-adenomatous-polyposis
#3
Tomoaki Hirashima, Shinobu Ohnuma, Hideaki Karasawa, Kazuhiro Watanabe, Hirofumi Imoto, Takeshi Aoki, Katsuyoshi Kudoh, Naoki Tanaka, Munenori Nagao, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
We here report a case of endoscopy-assisted partial duodenal resection for duodenal adenoma in a patient with familial adenomatous polyposis(FAP). A male underwent total proctocolectomy with ileal pouch anal anastomosis in 1997. Since 2004, duodenal adenomas occurred and the atypical grade of adenoma was gradually aggravated. Therefore, he underwent endoscopy-assisted partial duodenal resection in 2013. The pathological finding of the specimen showed well-differentiated tubular adenocarcinoma(pM, ly0, v0). No recurrence has been observed at 4 years after the operation...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29627174/short-term-outcomes-in-children-undergoing-restorative-proctocolectomy-with-ileal-pouch-anal-anastomosis
#4
Katerina Dukleska, Loren Berman, Allison A Aka, Charles D Vinocur, Erin A Teeple
INTRODUCTION: Patients with familial adenomatous polyposis (FAP) and ulcerative colitis (UC) commonly undergo restorative proctocolectomy with ileal-pouch anal anastomosis (RP-IPAA). We sought to describe patient characteristics and postoperative outcomes in this patient population. METHODS: Using the National Surgical Quality Improvement Program-Pediatric Participant Use Files from 2012 to 2015, children who were 6-18years old who underwent RP-IPAA for FAP or UC were identified...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29617820/fecal-incontinence-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#5
Phillip Gu, M Ellen Kuenzig, Gilaad G Kaplan, Mark Pimentel, Ali Rezaie
Background: Understanding of the prevalence, pathophysiology, and management of fecal incontinence (FI) in inflammatory bowel disease (IBD) patients without an ileal pouch anal anastomosis (IPAA) is suboptimal. We conducted a systematic review and meta-analysis on the prevalence, pathophysiology, and management of primary FI in IBD patients without IPAA. Methods: We searched MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews (1966 through March 2017) for studies on the prevalence, physiology, or management of FI in IBD patients without IPAA...
March 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29564356/chinese-research-into-severe-ulcerative-colitis-has-increased-in-quantity-and-complexity
#6
Cheng-Xin Luo, Zhong-Hui Wen, Yu Zhen, Zhu-Jun Wang, Jing-Xi Mu, Min Zhu, Qin Ouyang, Hu Zhang
AIM: To investigate the current state of research output from Chinese studies into severe ulcerative colitis (SUC) using a bibliometric analysis of publications. METHODS: The contents of the Chinese periodical databases WANFANG, VIP, and China National Knowledge Infrastructure were searched for all papers regarding UC or SUC published in last the 15 years (from 2001 to 2015). The number of publications in each year was recorded to assess the temporal trends of research output...
March 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29549433/impact-of-sex-on-30-day-complications-and-long-term-functional-outcomes-following-ileal-pouch-anal-anastomosis-for-chronic-ulcerative-colitis
#7
Nicholas P McKenna, Eric J Dozois, John H Pemberton, Amy L Lightner
PURPOSE: To determine the impact of patient sex on operative characteristics, short-term complications, and long-term functional outcomes following ileal pouch-anal anastomosis (IPAA) for chronic ulcerative colitis (CUC). METHODS: A retrospective review was performed on all patients undergoing two- or three-stage IPAA for CUC at our institution between January 2002 and August 2013. Patient demographics, operative characteristics, 30-day postoperative complications, and long-term functional outcomes from annual survey data were analyzed comparing men and women patients...
March 16, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29534812/risk-factors-for-organ-space-infection-after-ileal-pouch-anal-anastomosis-for-chronic-ulcerative-colitis-an-acs-nsqip-analysis
#8
Nicholas P McKenna, Amy E Glasgow, Robert R Cima, Elizabeth B Habermann
BACKGROUND: Organ space infection (OSI) after ileal pouch anal anastomosis (IPAA) is a devastating complication. The aim of this was study was to determine separately risk factors for OSI after total proctocolectomy (TPC) with IPAA and completion proctectomy (CP) with IPAA. METHODS: 4049 patients with a diagnosis of chronic ulcerative colitis undergoing TPC with IPAA or CP with IPAA between 2005 and 2015 were identified in the American College of Surgeons National Surgical Quality Improvement Program database...
March 6, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29520456/mri-defecography-of-the-ileal-pouch-anal-anastomosis-contributes-little-to-the-understanding-of-functional-outcome
#9
M L Sunde, A Negård, T Øresland, N Bakka, J T Geitung, A E Færden
PURPOSE: Variability in functional outcome after ileal pouch-anal anastomosis (IPAA) is to a large extent unexplained. The aim of this study was to use MRI to evaluate the morphology, emptying pattern and other pathology that may explain differences in functional outcome between well-functioning and poorly functioning pouch patients. A secondary aim was to establish a reference of normal MRI findings in pelvic pouch patients. METHODS: From a previous study, the best and worst functioning patients undergoing IPAA surgery between 2000 and 2013 had been identified and examined with manovolumetric tests (N = 47)...
March 9, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29511399/clinical-implication-of-enlarged-prostate-in-patients-with-the-ileal-pouch-anal-anastomosis-for-inflammatory-bowel-disease
#10
Lei Lian, Emmanuel Obusez, Erick M Remer, Manoj Monga, Bo Shen
Background: Enlarged prostate is often noticed in patients with ileal pouch-anal anastomosis (IPAA) in our clinical practice. The aims were to identify the factors associated with enlarged prostate and to investigate its clinical implications. Methods: IPAA patients with available prostate imaging after IPAA were included. Prostate length and width were measured in the axial plane and height in coronal plane. Prostate volume was calculated with the formula (length × width × height) × π/6...
February 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29502228/endoluminal-vacuum-assisted-therapy-as-treatment-for-anastomotic-leak-after-ileal-pouch-anal-anastomosis-a-pilot-study
#11
M Rottoli, M P Di Simone, C Vallicelli, L Vittori, G Liguori, L Boschi, G Poggioli
BACKGROUND: Anastomotic leak after ileal pouch-anal anastomosis (IPAA) could lead to poor functional results and failure of the pouch. The aim of the present study was to analyze the outcomes of the vacuum-assisted closure therapy as the unique treatment for anastomotic leaks following IPAA without any additional surgical operations. METHODS: Consecutive patients with anastomotic leak after IPAA treated at our institution between March 2016 and March 2017 were prospectively enrolled...
March 3, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29462381/restorative-surgery-in-patients-with-primary-sclerosing-cholangitis-and-ulcerative-colitis-following-a-colectomy
#12
Caroline Nordenvall, Ola Olén, Per Johan Nilsson, Anders Ekbom, Matteo Bottai, Pär Myrelid, Annika Bergquist
Background: Studies on surgical procedures in patients with concomitant primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) have mainly been restricted to single centers. The aim was to compare surgical treatment of UC with or without PSC in a nationwide study. Methods: A cohort study including all patients diagnosed with UC between 1987 and 2014 in Sweden was undertaken. The impact of PSC on the risk of colectomy, the chance of restorative surgery, and risk of failure (presence of a stoma) following restorative surgery were estimated...
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29456982/early-outcome-of-patient-with-ulcerative-colitis-who-received-high-dose-of-steroid-and-underwent-two-staged-total-proctocolectomy
#13
Hajar Khazraei, Alimohammad Bananzadeh, Seyed Vahid Hosseini
Background: Ulcerative colitis (UC) is an idiopathic inflammatory disorder. Currently, the final treatment is colectomy. The aim of this study was to investigate the outcomes of proctocolectomy in patients that used a high dose of prednisolone. Materials and Methods: Seventy-five patients presenting for surgical management of histopathologically proven UC. All patients were offered total proctocolectomy (TPC) with ileal pouch-anal anastomosis (IPAA). Patients were divided into two groups: low dose of steroids (Group A) and high dose of steroid (Group B) consumers...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29434447/enteral-nutrition-combined-with-glutamine-promotes-recovery-after-ileal-pouch-anal-anastomosis-in-rats
#14
Yan-Yan Xu, An-Qi He, Gang Liu, Kai-Yu Li, Jian Liu, Tong Liu
AIM: To assess the effect of enteral nutrition (EN) supplemented with glutamine on recovery after ileal pouch-anal anastomosis (IPAA) in rats, to provide an experimental basis for nutritional support in patients with ulcerative colitis (UC) after IPAA. METHODS: Male Sprague-Dawley (SD) rats were randomly divided into three groups ( n = 8) after IPAA operation using a microsurgical technique. From the third postoperative day, rats in the control group, EN group, and immune nutrition (IN) group were fed standard rat chow, short peptide EN, and short peptide EN combined with glutamine ad libitum , respectively...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29423501/association-of-sulindac-and-erlotinib-vs-placebo-with-colorectal-neoplasia-in-familial-adenomatous-polyposis-secondary-analysis-of-a-randomized-clinical-trial
#15
N Jewel Samadder, Scott K Kuwada, Kenneth M Boucher, Kathryn Byrne, Priyanka Kanth, Wade Samowitz, David Jones, Sean V Tavtigian, Michelle Westover, Therese Berry, Kory Jasperson, Lisa Pappas, Laurel Smith, Danielle Sample, Randall W Burt, Deborah W Neklason
Importance: Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for colorectal polyps and cancer. A combination of sulindac and erlotinib led to a 71% reduction in duodenal polyp burden in a phase 2 trial. Objective: To evaluate effect of sulindac and erlotinib on colorectal adenoma regression in patients with FAP. Design, Setting, and Participants: Prespecified secondary analysis for colorectal adenoma regression was carried out using data from a double-blind, randomized, placebo-controlled trial, enrolling 92 patients with FAP, conducted from July 2010 to June 2014 in Salt Lake City, Utah...
February 8, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29422639/ileal-pouch-of-ulcerative-colitis-and-familial-adenomatous-polyposis-patients-exhibit-modulation-of-autophagy-markers
#16
Nielce Maria Paiva, Lívia Bitencourt Pascoal, Leandro Minatel Vidal Negreiros, Mariana Portovedo, Andressa Coope, Maria de Lourdes Setsuko Ayrizono, Claudio Saddy Rodrigues Coy, Marciane Milanski, Raquel Franco Leal
Total retocolectomy with ileal pouch-anal anastomosis (IPAA) is the surgery of choice for patients with ulcerative colitis (UC) that are refractory to clinical treatment. Pouchitis is one of the most common complications after this procedure. Defects in autophagy have been reported in inflammatory bowel diseases. However, there are no studies on the IP. Therefore, we studied markers for autophagy in the IP mucosa of UC and FAP patients comparing them to controls with a normal distal ileum. Sixteen patients with IP in "J" shape, asymptomatic and with endoscopically normal IP were evaluated...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29394669/-a-case-of-local-recurrence-with-negative-fdg-pet-findings-after-a-total-proctocolectomy-for-ulcerative-colitis-associated-with-colon-cancer-with-retroperitoneal-penetration
#17
Masumi Kumakura, Toshiro Ogura, Yu Muta, Tetsuya Ito, Azusa Yamamoto, Kunihiko Amano, Toru Ishiguro, Minoru Fukuchi, Erito Mochiki, Hideyuki Ishida
We report the case of a 55-year-old man who successfully underwent resection of a recurrence of ulcerative colitis(UC)- associated colon cancer located in the pancreatic body and left kidney. The patient had undergone an emergency laparotomy (total proctocolectomy with stapled ileal-pouch anal anastomosis)for the treatment of a descending colon cancer with retroperitoneal penetration associated with UC at the age of 50 years. At that time, histological examinations revealed a mucinous carcinoma that was classified as Stage II colon cancer...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29391089/abdominal-visceral-fat-area-and-chronic-pouchitis-after-ileal-pouch-anal-anastomosis
#18
Vivek Pandrangi, Daniel Mandel, Norman Gellada, Dionisio Mieses, Cindy Kallman, Karen Zaghiyan, Phillip Fleshner
Chronic pouchitis (CP) after ileal pouch-anal anastomosis is a significant clinical problem. Adipose tissues produce antiinflammatory cytokines and chemokines. We evaluated the association between abdominal visceral fat area (VFA) and CP. Patients with a preoperative CT evaluation were included. The diagnosis of CP was confirmed in all cases by endoscopy with afferent ileal limb intubation. Patients were allocated into groups of high VFA and low VFA. The study cohort of 52 patients had a median body mass index of 22 (range, 14-32)...
October 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29362331/-surgical-case-of-ulcerative-colitis-accompanied-with-rectal-cancer-combined-with-transanal-minimally-invasive-surgery
#19
Hideaki Kawakita, Kenji Katsumata, Yoshiaki Osaka, Hitoshi Saito, Kazuhiko Tamura, Tomoki Shirota, Kenta Kasahara, Minoru Kuwabara, Masatoshi Shigoka, Takaaki Matsudo, Masanobu Enomoto, Tetsuo Ishizaki, Masayuki Hisada, Kazuhiko Kasuya, Akihiko Tsuchida
A46 -year-old man developed ulcerative colitis at the age of 19 years. Although the colitis was medically treated, it relapsed and repeated over time. Periodic lower gastrointestinal endoscopy revealed lower rectal cancer, and he was referred to our department of surgery. Previous steroid therapy induced diabetes, and he was obese, with a height of 170.3 cm, weight of 89.6 kg, and BMI of 30.89 kg/m2, indicating that laparoscopic dissection near the anus would be difficult to perform. Therefore, the patient was scheduled for transanal minimally invasive surgery(TAMIS)...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29361101/systematic-review-with-meta-analysis-anti-tnf-therapy-in-refractory-pouchitis-and-crohn-s-disease-like-complications-of-the-pouch-after-ileal-pouch-anal-anastomosis-following-colectomy-for-ulcerative-colitis
#20
Mathilde Huguet, Bruno Pereira, Marion Goutte, Félix Goutorbe, Anne Dubois, Gilles Bommelaer, Anthony Buisson
Background: Inflammatory complications including chronic refractory pouchitis and Crohn's disease (CD)-like complications of the pouch are common complications after ileal pouch-anal anastomosis (IPAA) following colectomy for ulcerative colitis (UC). We performed a systematic review and meta-analysis to evaluate the efficacy of anti-TNF therapy in distinguishing patients with chronic refractory pouchitis from those with CD-like complications of the pouch. Methods: We performed a systematic literature search to identify articles and abstracts reporting anti-TNF agents efficacy in treating inflammatory complications of the pouch after IPAA for UC...
January 18, 2018: Inflammatory Bowel Diseases
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