keyword
MENU ▼
Read by QxMD icon Read
search

Biliverdin

keyword
https://www.readbyqxmd.com/read/28795139/elevated-preoperative-serum-bilirubin-improves-reperfusion-injury-and-survival-postliver-transplantation
#1
Vinzent Spetzler, Nicolas Goldaracena, Johann Moritz Kaths, Max Marquez, Markus Selzner, Nazia Selzner
BACKGROUND: The cytoprotective effects of hemeoxygenase-1 and its product biliverdin/bilirubin are widely acknowledged in experimental transplant medicine. However, its potentially beneficial effect during organ reperfusion is not established. METHODS: In a matched study, we compared markers of reperfusion injury (alanine aminotransferase/aspartate aminotransferase) and transplantation outcome (complication rates, liver function, and survival) between recipient groups with "normal" versus "increased" preoperative bilirubin values...
August 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28782566/small-monomeric-and-highly-stable-near-infrared-fluorescent-markers-derived-from-the-thermophilic-phycobiliprotein-apcf2
#2
Wen-Long Ding, Dan Miao, Ya-Nan Hou, Su-Ping Jiang, Bao-Qin Zhao, Ming Zhou, Hugo Scheer, Kai-Hong Zhao
Biliproteins have extended the spectral range of fluorescent proteins into the region of maximal transmission of most tissues and are favorable for multiplexing, but their application presents considerable challenges. Their fluorescence derives from open-chain tetrapyrrole chromophores which often require the introduction of dedicated reductases and lyases. In addition, their fluorescence yield generally decreases with increasing wavelengths and depends strongly on the state of the binding protein. We report fluorescent biliproteins, termed BDFPs, that are derived from the phycobilisome core subunit, ApcF2: this subunit is induced in the thermophilic cyanobacterium, Chroococcidiopsis thermalis, by far-red light and binds phycocyanobilin non-covalently...
August 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28771589/structural-and-mutational-analyses-of-the-leptospira-interrogans-virulence-related-heme-oxygenase-provide-insights-into-its-catalytic-mechanism
#3
Anabel Soldano, Sebastián Klinke, Lisandro H Otero, Mario Rivera, Daniela L Catalano-Dupuy, Eduardo A Ceccarelli
Heme oxygenase from Leptospira interrogans is an important virulence factor. During catalysis, redox equivalents are provided to this enzyme by the plastidic-type ferredoxin-NADP+ reductase also found in L. interrogans. This process may have evolved to aid this bacterial pathogen to obtain heme-iron from their host and enable successful colonization. Herein we report the crystal structure of the heme oxygenase-heme complex at 1.73 Å resolution. The structure reveals several distinctive features related to its function...
2017: PloS One
https://www.readbyqxmd.com/read/28756878/heme-oxygenase-1-a-new-druggable-target-in-the-management-of-chronic-and-acute-myeloid-leukemia
#4
REVIEW
Loredana Salerno, Giuseppe Romeo, Maria N Modica, Emanuele Amata, Valeria Sorrenti, Ignazio Barbagallo, Valeria Pittalà
Heme oxygenase-1 (HO-1) is the enzyme catalyzing the rate-limiting oxidative degradation of cellular heme into free iron, carbon monoxide (CO), and biliverdin, which is then rapidly converted into bilirubin. By means of these catabolic end-products and by removal of pro-oxidant heme, HO-1 exerts antioxidant, antiapoptotic, and immune-modulating effects, leading to overall cytoprotective and beneficial functions in mammalian cells. Therefore, HO-1 is considered a survival molecule in various stress-related conditions...
July 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28708313/human-biliverdin-reductase-regulates-the-molecular-mechanism-underlying-cancer-development
#5
Min Zhang, Wei Xin, Zhi Yi, Yue Li, Ying Liu, Hongyue Zhang, He Chen, Xinxin Chen, Shujie Tan, Daling Zhu
Human biliverdin reductase (hBVR), is an enzyme, that converts biliverdin to bilirubin, and has been implicated in epithelial-mesenchymal transition?EMT? in breast cancer. However, few studies have investigated the role of hBVR in cell apoptosis in other cancers. Therefore, the aim of this study was to investigate the effects of hBVR in several lines of cancer cells. The results of this study showed that hBVR expression was up-regulated in breast, lung, and liver cancers, but not ovarian cancer. Moreover, hBVR inhibition by small interfering RNA (si-hBVR) attenuated cell survival and increased caspase-3 protein expression, which was mediated by the ERK1/2 signaling pathway in relative cancer cells...
July 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28672984/biliverdin-administration-ameliorates-cerebral-ischemia-reperfusion-injury-in-rats-and-is-associated-with-proinflammatory-factor-downregulation
#6
Jun-Jie Li, Zhi-Yao Zou, Jia Liu, Liu-Lin Xiong, Hai-Yan Jiang, Ting-Hua Wang, Jian-Lin Shao
Biliverdin (BV), one of the heme oxygenase-1 (HO-1) catalytic products, has been demonstrated to have protective effects in liver ischemia reperfusion injury (IRI). The present study aimed to explore the effects of BV on cerebral IRI, and to investigate the potential mechanisms thereof. Adult male SD rats, weighing 200-240 g, were randomly divided into sham (group S), cerebral ischemia reperfusion control (group C) and BV (group BV) groups. Rats in group C underwent transient middle cerebral artery occlusion (tMCAO) and received 2 ml normal saline; rats in group BV received BV (35 mg/kg) intraperitoneally 15 min prior to reperfusion and 4 h after reperfusion, then twice a day thereafter for 5 days...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28655775/the-iron-chaperone-poly-rc-binding-protein-2-forms-a-metabolon-with-the-heme-oxygenase-1-cytochrome-p450-reductase-complex-for-heme-catabolism-and-iron-transfer
#7
Izumi Yanatori, Des R Richardson, Shinya Toyokuni, Fumio Kishi
Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)/NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron. Moreover, intestinal iron is incorporated as ferrous iron, which is transported via the iron importer, divalent metal transporter 1 (DMT1). Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1...
June 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28654333/identification-of-genes-for-synthesis-of-the-blue-pigment-biliverdin-ix%C3%AE-in-the-blue-coral-heliopora-coerulea
#8
Yuki Hongo, Nina Yasuda, Satoshi NagaI
Heliopora coerulea is the only species in the subclass Octocorallia that has a crystalline aragonite skeleton. The skeleton has been reported to contain the blue pigment, biliverdin IXα, which is formed by heme oxygenase (HO) during heme decomposition. There is little information regarding gene expression in H. coerulea; therefore, the biosynthesis pathway for biliverdin IXα is poorly understood. To identify the genes related to heme synthesis and degradation, metatranscripts of H. coerulea and its symbiont Symbiodinium spp...
April 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28641882/ferredoxin-dependent-bilin-reductases-in-eukaryotic-algae-ubiquity-and-diversity
#9
Nathan C Rockwell, J Clark Lagarias
Linear tetrapyrroles (bilins) are produced from heme by heme oxygenase, usually forming biliverdin IXα (BV). Fungi and bacteria use BV as chromophore for phytochrome photoreceptors. Oxygenic photosynthetic organisms use BV as a substrate for ferredoxin-dependent bilin reductases (FDBRs), enzymes that produce diverse reduced bilins used as light-harvesting pigments in phycobiliproteins and as photoactive photoreceptor chromophores. Bilin biosynthesis is essential for phototrophic growth in Chlamydomonas reinhardtii despite the absence of phytochromes or phycobiliproteins in this organism, raising the possibility that bilins are more generally required for phototrophic growth by algae...
May 31, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28607990/reaction-intermediates-in-the-heme-degradation-reaction-by-hutz-from-vibrio-cholerae
#10
Takeshi Uchida, Yukari Sekine, Nobuhiko Dojun, Ariel Lewis-Ballester, Izumi Ishigami, Toshitaka Matsui, Syun-Ru Yeh, Koichiro Ishimori
HutZ is a heme-degrading enzyme in Vibrio cholerae. It converts heme to biliverdin via verdoheme, suggesting that it follows the same reaction mechanism as that of mammalian heme oxygenase. However, none of the key intermediates have been identified. In this study, we applied steady-state and time-resolved UV-vis absorption and resonance Raman spectroscopy to study the reaction of the heme-HutZ complex with H2O2 or ascorbic acid. We characterized three intermediates: oxyferrous heme, meso-hydroxyheme, and verdoheme complexes...
June 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28602760/how-to-increase-brightness-of-near-infrared-fluorescent-proteins-in-mammalian-cells
#11
Anton A Shemetov, Olena S Oliinyk, Vladislav V Verkhusha
Numerous near-infrared (NIR) fluorescent proteins (FPs) were recently engineered from bacterial photoreceptors but lack of their systematic comparison makes researcher's choice rather difficult. Here we evaluated side-by-side several modern NIR FPs, such as blue-shifted smURFP and miRFP670, and red-shifted mIFP and miRFP703. We found that among all NIR FPs, miRFP670 had the highest fluorescence intensity in various mammalian cells. For instance, in common HeLa cells miRFP703, mIFP, and smURFP were 2-, 9-, and 53-fold dimmer than miRFP670...
June 22, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28601647/metalloproteomic-and-differential-expression-in-plasma-in-a-rat-model-of-type-1-diabetes
#12
Camila Pereira Braga, José Cavalcante Souza Vieira, Aline de Lima Leite, Ana Angélica Henrique Fernandes, Marília Afonso Rabelo Buzalaf, Pedro de Magalhães Padilha
Type 1 diabetes is characterized by hyperglycemia, which in the chronic stage is associated with abnormalities in lipids, protein and, carbohydrate metabolism, as well as oxidative stress. New strategies for prevention and treatment are needed, as type 1 diabetes affects life quality and survival, and involves high-cost treatment. Proteomic and metalloproteomic studies can elucidate the functional and physiological aspects of biomolecules. In the present study, differential proteomics was used to identify potential biomarkers of diabetes in rat plasma associated with copper, selenium, zinc, and magnesium fractionation in control and diabetic rats, as well as diabetic rats treated with insulin...
June 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28588733/differences-in-the-sensitivity-of-ovarian-cancer-to-photodynamic-therapy-and-the-mechanisms-for-those-differences
#13
Yoshihito Yokoyama, Tatsuhiko Shigeto, Rie Miura, Asami Kobayashi, Makito Mizunuma, Aisa Yamauchi, Masayuki Futagami, Hideki Mizunuma
Protoporphyrin IX (PpIX) levels are crucial to the antitumor action of photodynamic therapy (PDT). In the present study, the underling molecular mechanisms for the variation in PpIX levels in ovarian cancer cells were investigated. Five ovarian cancer cell lines were subcutaneously grafted onto the backs of nude mice. Once tumors had developed, 5-aminolevulinic acid methyl ester hydrochloride (methyl-ALA) was administered intraperitoneally and the tumor was irradiated twice/week. PpIX levels in the tumor were assayed using high-performance liquid chromatography...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28576353/reprint-of-heme-oxygenase-1-affects-granulopoiesis-in-mice-through-control-of-myelocyte-proliferation
#14
Karolina Bukowska-Strakova, Maciej Ciesla, Krzysztof Szade, Witold Norbert Nowak, Robert Straka, Agata Szade, Malgorzata Tyszka-Czochara, Karolina Najder, Anna Konturek, Maciej Siedlar, Jozef Dulak, Alicja Jozkowicz
Heme oxygenase-1 (HO-1) is stress-inducible, cytoprotective enzyme degrading heme to carbon monoxide (CO), biliverdin and Fe(2+). We showed that HO-1 knock-out mice (HO-1(-/-)) have a twofold higher level of granulocytes than wild type (WT) mice, despite decreased concentration of granulocyte colony-stimulating factor (G-CSF) in the blood and reduced surface expression of G-CSF receptor on the hematopoietic precursors. This suggests the effect of HO-1 on granulopoiesis. Here we aimed to determine the stage of granulopoiesis regulated by HO-1...
June 2017: Immunobiology
https://www.readbyqxmd.com/read/28566503/heavy-metal-suicide
#15
Andreas Linkermann, Brent R Stockwell, Tom Vanden Berghe
In acute kidney injury (AKI), the majority of dying tubular cells succumbs to an iron-dependent form of regulated necrosis, referred to as ferroptosis. Ferroptosis is essentially mediated by iron-catalyzed lipid peroxidation upon GPX4 dysfunction. Heme oxygenase 1 (HO-1) is a master regulator of intracellular free iron due to the conversion of heme to iron, carbon monoxide, and biliverdin(12), and therefore represents a potential regulator of ferroptotic cell death. In this issue of AJP - Renal Physiology, Adedoyin et al...
May 31, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28560878/serial-metabolome-changes-in-a-prospective-cohort-of-subjects-with-influenza-viral-infection-and-comparison-with-dengue-fever
#16
Liang Cui, Jinling Fang, Eng Eong Ooi, Yie Hou Lee
Influenza virus infection (IVI) and dengue virus infection (DVI) are major public health threats. Between IVI and DVI, clinical symptoms can be overlapping yet infection-specific, but host metabolome changes are not well-described. Untargeted metabolomics and targeted oxylipinomic analyses were performed on sera serially collected at three phases of infection from a prospective cohort study of adult subjects with either H3N2 influenza infection or dengue fever. Untargeted metabolomics identified 26 differential metabolites, and major perturbed pathways included purine metabolism, fatty acid biosynthesis and β-oxidation, tryptophan metabolism, phospholipid catabolism, and steroid hormone pathway...
June 12, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28560357/impact-of-heme-on-specific-antibody-production-in-mice-promotive-inhibitive-or-null-outcome-is-determined-by-its-concentration
#17
Guofu Li, Haiyan Xue, Zeng Fan, Yun Bai
Free heme is an endogenous danger signal that provokes innate immunity. Active innate immunity provides a precondition of an effective adaptive immune response. However, heme catabolites, CO, biliverdin and bilirubin trigger immunosuppression. Furthermore, free heme induces expression of heme oxygenase-1 to increase production of CO, biliverdin and bilirubin. As such, free heme can play a paradoxical role in adaptive immunity. What is the outcome of the animal immune response to an antigen in the presence of free heme? This question remains to be explored...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28554854/hgf-induces-emt-in-non-small-cell-lung-cancer-through-the-hbvr-pathway
#18
Fang Liu, Shasha Song, Zhi Yi, Min Zhang, Jiali Li, Fang Yang, Hongtao Yin, Xiufeng Yu, Chao Guan, Ying Liu, Zizhen Liu, Jing Wang, Daling Zhu
The epithelial-to-mesenchymal transition (EMT) is a crucial event during non-small-cell lung cancer (NSCLC) invasion and metastasis. However, the mechanisms involved in NSCLC EMT have not been fully clarified. Hepatocyte growth factor (HGF) and human biliverdin reductase (hBVR) are reported to contribute to EMT in several diseases. Here, we show that compared with transforming growth factor beta (TGF-β), fibroblast growth factor (FGF), and epidermal growth factor (EGF), HGF is an important cell factor for EMT in NSCLC cell lines A549 and H460...
May 26, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28500721/structural-and-vibrational-characterization-of-the-chromophore-binding-site-of-bacterial-phytochrome-agp1
#19
Aref Takiden, Francisco Velazquez-Escobar, Jovan Dragelj, Anna Lena Woelke, Ernst-Walter Knapp, Patrick Piwowarski, Franz Bart, Peter Hildebrandt, Maria Andrea Mroginski
Agp1 is a prototypical bacterial phytochrome from Agrobacterium fabrum harboring a biliverdin cofactor which reversibly photoconverts between a red-light-absorbing (Pr) and a far-red-light-absorbing (Pfr) states. The reaction mechanism involves the isomerization of the bilin-chromophore followed by large structural changes of the protein matrix that are coupled to protonation dynamics at the chromophore binding site. Histidines His250 and His280 participate in this process. Although the three-dimensional structure of Agp1 has been solved at high resolution, the precise position of hydrogen atoms and protonation pattern in the chromophore binding pocket has not been investigated yet...
May 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28499219/oxidant-and-anti-oxidant-status-in-common-brain-tumors-correlation-to-tp53-and-human-biliverdin-reductase
#20
Pinar Atukeren, Sena Oner, Oguz Baran, Rahsan Kemerdere, Bulent Eren, Ufuk Cakatay, Taner Tanriverdi
OBJECTIVE: To assess oxidant and antioxidant status in patients with common brain tumors; namely meningiomas, low-grade gliomas (LGG) and high-grade gliomas (HGG) and to compare with normal brain tissues. PATIENTS AND METHODS: Almost nine biomarkers were measured in 59 brain tumors obtained during surgery and 15 normal brain tissues that were collected during autopsy. Results were compared between two groups. RESULTS: In general, protein oxidation and lipid peroxidation increased while antioxidant capacity decreased significantly in tumors compared to the controls (p<0...
May 3, 2017: Clinical Neurology and Neurosurgery
keyword
keyword
86327
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"