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https://www.readbyqxmd.com/read/29338386/estrogen-estrogen-receptor-%C3%AE-signaling-facilitates-bilirubin-metabolism-in-regenerating-liver-through-regulating-cytochrome-p450-2a6-expression
#1
Ta-Lun Kao, Yao-Li Chen, Yu-Ping Kuan, Wei-Chun Chang, Yu-Chen Ho, Shuyuan Yeh, Long-Bin Jeng, Wen-Lung Ma
BACKGROUND: After living donor liver transplantation (LDLT), rising serum bilirubin levels commonly indicate insufficient numbers of hepatocytes are available to metabolize bilirubin into biliverdin. Recovery of bilirubin levels is an important marker of hepatocyte repopulation after LDLT. Cytochrome P450 (CYP) 2A6 in humans (or cyp2a4 in rodents) can function as "bilirubin oxidase." Functional hepatocytes contain abundant CYP2A6, which is considered a marker for hepatocyte function recovery...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29338093/longitudinal-profiles-of-metabolism-and-bioenergetics-associated-with-innate-immune-hormonal-inflammatory-responses-and-amino-acid-kinetics-in-severe-sepsis-and-systemic-inflammatory-response-syndrome-in-children
#2
Anna Maria Spanaki, Theonymfi Tavladaki, Helen Dimitriou, Andrey V Kozlov, J Catharina Duvigneau, Eftychia Meleti, Adelheid Weidinger, Evangelos Papakonstantinou, George Briassoulis
BACKGROUND: Experimental data indicate that sepsis influences the mitochondrial function and metabolism. We aim to investigate longitudinal bioenergetic, metabolic, hormonal, amino-acid, and innate immunity changes in children with sepsis. METHODS: Sixty-eight children (sepsis, 18; systemic inflammatory response syndrome [SIRS], 23; healthy controls, 27) were enrolled. Plasma amino acids were determined by high-performance liquid chromatography (HPLC); flow-cytometry expressed as mean fluorescence intensity (MFI) of heat shock protein (HSP) levels from monocytes (m) and neutrophils (n); resistin, adiponectin, and extracellular (e) HSPs evaluated by ELISA; ATP levels in white blood cells by luciferase luminescent assay; lipid peroxidation products (TBARS) by colorimetric test; nitrite and nitrate levels by chemiluminescent assay; biliverdin reductase (BVR) activity by enzymatic assay; and energy-expenditure (EE) by E-COVX...
January 16, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29249571/redox-functions-of-heme-oxygenase-1-and-biliverdin-reductase-in-diabetes
#3
REVIEW
Luc Rochette, Marianne Zeller, Yves Cottin, Catherine Vergely
In patients with diabetes, the hyperglycemia-driven excess generation of reactive oxygen species (ROS) induces oxidative stress (OS) in a variety of tissues. OS is closely associated with chronic inflammation and has a key role in the pathogenesis of vascular complications. The enzymes that generate ROS and gasotransmitters are redox regulated and are implicated in cellular signaling. As a result of cellular metabolism, cells produce significant amounts of carbon monoxide (CO), mainly from heme degradation catalyzed by heme oxygenases (HOs)...
December 14, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29220548/haem-oxygenase-a-functionally-diverse-enzyme-of-photosynthetic-organisms-and-its-role-in-phytochrome-chromophore-biosynthesis-cellular-signalling-and-defence-mechanisms
#4
REVIEW
Lovely Mahawar, G S Shekhawat
Haem oxygenase (HO) is a universal enzyme that catalyzes stereospecific clevage of haem to BV IX α and liberates Fe+2 ion and CO as byproduct. Beside haem degradation, it has important functions in plants that include cellular defence, stomatal regulation, iron mobilization, phytochrome chromophore synthesis and lateral root formation. Phytochromes are an extended family of photoreceptors with a molecular mass of 250 kDa and occur as a dimer made up of two equivalent subunits of 125 kDa each. Each subunit is made of two components; the chromophore, a light capturing pigment molecule and the apoprotein...
December 8, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29195835/absence-of-the-biliverdin-reductase-a-gene-is-associated-with-increased-endogenous-oxidative-stress
#5
Weiyu Chen, Ghassan J Maghzal, Anita Ayer, Cacang Suarna, Louise L Dunn, Roland Stocker
Bilirubin, a byproduct of heme catabolism, has been shown to be an effective lipid-soluble antioxidant in vitro. Bilirubin is able to inhibit free radical chain reactions and protects against oxidant-induced damage in vitro and ex vivo. However, direct evidence for bilirubin's antioxidant effects in vivo remains limited. As bilirubin is formed from biliverdin by biliverdin reductase, we generated global biliverdin reductase-a gene knockout (Bvra-/-) mice to assess the contribution of bilirubin as an endogenous antioxidant...
November 28, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29163402/pharmacological-induction-of-heme-oxygenase-1-impairs-nuclear-accumulation-of-herpes-simplex-virus-capsids-upon-infection
#6
Francisco J Ibáñez, Mónica A Farías, Angello Retamal-Díaz, Janyra A Espinoza, Alexis M Kalergis, Pablo A González
Heme oxygenase-1 (HO-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), as well as cytokines, among others. Its activity can be positively modulated by cobalt protoporphyrin (CoPP) and negatively by tin protoporphirin (SnPP). Once induced, HO-1 degrades iron-containing heme into ferrous iron (Fe(2+)), carbon monoxide (CO) and biliverdin. Importantly, numerous products of HO-1 are cytoprotective with anti-apoptotic, anti-oxidant, anti-inflammatory, and anti-cancer effects...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29156487/evolution-and-molecular-mechanism-of-four-electron-reducing-ferredoxin-dependent-bilin-reductases-from-oceanic-phages
#7
Benjamin Ledermann, Meike Schwan, Johannes A Sommerkamp, Eckhard Hofmann, Oded Béjà, Nicole Frankenberg-Dinkel
Ferredoxin-dependent bilin reductases (FDBRs) are a class of enzymes reducing the heme metabolite biliverdin IXα (BV) to form open-chain tetrapyrroles used for light-perception and light-harvesting in photosynthetic organisms. Thus far, seven FDBR families have been identified, each catalyzing a distinct reaction and either transferring two or four electrons from ferredoxin onto the substrate. The newest addition to the family is PcyX, originally identified from metagenomics data derived from phage. Phylogenetically, PcyA is the closest relative catalyzing the reduction of BV to phycocyanobilin...
November 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29122256/cupping-therapy-an-analysis-of-the-effects-of-suction-on-skin-and-the-possible-influence-on-human-health
#8
REVIEW
Duane T Lowe
BACKGROUND: Cupping therapy is a traditional therapy that has been employed worldwide for thousands of years. Despite a lack of quality clinical studies evaluating the efficacy of cupping therapy, its long history and widespread use throughout the world suggests the commonly claimed health benefits should not be completely discounted as without merit. PURPOSE: The goal of this paper is to present the research detailing what is known concerning the effects of suction on skin and underlying tissue, and the reaction of the body to that stimulus...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29110341/hemin-and-bile-pigments-are-the-secondary-structure-regulators-of-intrinsically-disordered-antimicrobial-peptides
#9
Ferenc Zsila, Tünde Juhász, Szilvia Bősze, Kata Horváti, Tamás Beke-Somfai
The interaction of protoporphyrin compounds of human origin with the major bee venom component melittin (26 a.a., Z +6) and its hybrid derivative (CM15, 15 a.a., Z +6) were studied by a combination of various spectroscopic methods. Throughout a two-state, concentration-dependent process, hemin and its metabolites (biliverdin, bilirubin, bilirubin ditaurate) increase the parallel β-sheet content of the natively unfolded melittin, suggesting the oligomerization of the peptide chains. In contrast, α-helix promoting effect was observed with the also disordered but more cationic CM15...
November 7, 2017: Chirality
https://www.readbyqxmd.com/read/29091422/engineering-an-e-coli-near-infrared-light-sensor
#10
Nicholas T Ong, Evan J Olson, Jeffrey J Tabor
Optogenetics is a technology wherein researchers combine light and genetically engineered photoreceptors to control biological processes with unrivaled precision. Near-infrared (NIR) wavelengths (>700 nm) are desirable optogenetic inputs due to their low phototoxicity and spectral isolation from most photoproteins. The bacteriophytochrome photoreceptor 1 (BphP1), found in several purple photosynthetic bacteria, senses NIR light and activates transcription of photosystem promoters by binding to and inhibiting the transcriptional repressor PpsR2...
November 9, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29078307/efficient-synthesis-of-phycocyanobilin-in-mammalian-cells-for-optogenetic-control-of-cell-signaling
#11
Youichi Uda, Yuhei Goto, Shigekazu Oda, Takayuki Kohchi, Michiyuki Matsuda, Kazuhiro Aoki
Optogenetics is a powerful tool to precisely manipulate cell signaling in space and time. For example, protein activity can be regulated by several light-induced dimerization (LID) systems. Among them, the phytochrome B (PhyB)-phytochrome-interacting factor (PIF) system is the only available LID system controlled by red and far-red lights. However, the PhyB-PIF system requires phycocyanobilin (PCB) or phytochromobilin as a chromophore, which must be artificially added to mammalian cells. Here, we report an expression vector that coexpresses HO1 and PcyA with Ferredoxin and Ferredoxin-NADP+ reductase for the efficient synthesis of PCB in the mitochondria of mammalian cells...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29065700/murine-bone-marrow-mesenchymal-stromal-cells-respond-efficiently-to-oxidative-stress-despite-the-low-level-of-heme-oxygenases-1-and-2
#12
Witold Norbert Nowak, Hevidar Taha, Neli Kachamakova-Trojanowska, Jacek Stepniewski, Joanna Agata Markiewicz, Anna Kusienicka, Krzysztof Szade, Agata Szade, Karolina Bukowska-Strakova, Karolina Hajduk, Damian Klóska, Aleksandra Kopacz, Anna Grochot-Przeczek, Kathrin Barthenheier, Camille Cauvin, Jozef Dulak, Alicja Jozkowicz
AIMS: Mesenchymal stromal cells (MSCs) are heterogeneous cells from adult tissues, able to differentiate in vitro into adipocytes, osteoblasts or chondrocytes. Such cells are widely studied in regenerative medicine. However, the success of cellular therapy depends on the cell survival. Heme oxygenase-1 (HO-1, encoded by the Hmox1 gene), an enzyme converting heme to biliverdin, carbon monoxide, and Fe2+, is cytoprotective and can affect stem cell performance. Therefore, our study aimed to assess if Hmox1 is critical for survival and functions of murine bone marrow MSCs...
October 25, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29017728/near-infrared-fluorescent-proteins-engineered-from-bacterial-phytochromes-in-neuroimaging
#13
Kiryl D Piatkevich, Ho-Jun Suk, Suhasa B Kodandaramaiah, Fumiaki Yoshida, Ellen M DeGennaro, Mikhail Drobizhev, Thomas E Hughes, Robert Desimone, Edward S Boyden, Vladislav V Verkhusha
Several series of near-infrared (NIR) fluorescent proteins (FPs) were recently engineered from bacterial phytochromes but were not systematically compared in neurons. To fluoresce, NIR FPs utilize an enzymatic derivative of heme, the linear tetrapyrrole biliverdin, as a chromophore whose level in neurons is poorly studied. Here, we evaluated NIR FPs of the iRFP protein family, which were reported to be the brightest in non-neuronal mammalian cells, in primary neuronal culture, in brain slices of mouse and monkey, and in mouse brain in vivo...
November 21, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28962110/effect-of-the-herbal-formulation-shen-zhi-ling-on-an-app-ps1-mouse-model-of-alzheimer-s-disease-by-modulating-the-biliverdin-reductase-heme-oxygenase-1-system
#14
Sanli Xing, Dingzhu Shen, Chuan Chen, Beiling Wu, Huiying Chi
Shen-Zhi-Ling (SZL) oral liquid is a traditional Chinese medicine formula that is mainly used for the clinical treatment of mild to moderate Alzheimer's disease (AD). The aim of the present study was to investigate the effects and underlying mechanisms of SZL treatment on AD. APP/PS1 transgenic mice were utilized to evaluate the effect of SZL treatment (0.5 g/20 g/day). Morris water maze and Thioflavin S staining analyses were used to evaluate the cognitive impairment and β-amyloid plaques, respectively, while quantitative polymerase chain reaction and western blot analysis were performed to examine the mRNA and protein expression levels of heme oxygenase 1 (HO-1) and biliverdin reductase (BVR)...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28937855/eggshell-biliverdin-and-protoporphyrin-pigments-in-a-songbird-are-they-derived-from-erythrocytes-blood-plasma-or-the-shell-gland
#15
Rita Hargitai, Nóra Boross, Susanne Hámori, Eszter Neuberger, Zoltán Nyiri
Biliverdin and protoporphyrin pigments are deposited into the eggshell when the developing egg is in the shell gland. However, the site of synthesis of eggshell pigments is still uncertain, although it may influence the possible costs and potential functions of eggshell coloration in avian species. Eggshell pigments may be derived from red blood cells or be produced in other organs and then transferred to the shell gland, or they may be synthesized de novo in the shell gland. We studied in the canary (Serinus canaria) whether eggshell blue-green and brown pigmentations are associated with experimentally elevated anemia, female hematocrit level, immature erythrocyte percentage, and feces and plasma pigment levels during egg laying to find out the possible origin of eggshell pigments...
November 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28927849/metabolome-wide-association-study-of-peripheral-parasitemia-in-plasmodium-vivax-malaria
#16
Luiz Gustavo Gardinassi, Regina Joice Cordy, Marcus V G Lacerda, Jorge L Salinas, Wuelton M Monteiro, Gisely C Melo, André M Siqueira, Fernando F Val, ViLinh Tran, Dean P Jones, Mary R Galinski, Shuzhao Li
BACKGROUND: Plasmodium vivax is one of the leading causes of malaria worldwide. Infections with this parasite cause diverse clinical manifestations, and recent studies revealed that infections with P. vivax can result in severe and fatal disease. Despite these facts, biological traits of the host response and parasite metabolism during P. vivax malaria are still largely underexplored. Parasitemia is clearly related to progression and severity of malaria caused by P. falciparum, however the effects of parasitemia during infections with P...
December 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28900278/function-coupling-mechanism-of-phus-and-hemo-in-heme-degradation
#17
Michael J Y Lee, Ye Wang, Yafei Jiang, Xichen Li, Jianqiu Ma, Hongwei Tan, Keegan Turner-Wood, Mona N Rahman, Guangju Chen, Zongchao Jia
Most bacteria possess only one heme-degrading enzyme for obtaining iron, however few bacteria such as Pseudomonas aeruginosa express two, namely PhuS and HemO. While HemO is a well-known heme oxygenase, previously we discovered that PhuS also possesses heme degradation activity and generates verdoheme, an intermediate of heme breakdown. To understand the coexistence of these two enzymes, using the DFT calculation we reveal that PhuS effectively enhances heme degradation through its participation in heme hydroxylation, the rate limiting reaction...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899357/comparative-transcriptome-analysis-provides-clues-to-molecular-mechanisms-underlying-blue-green-eggshell-color-in-the-jinding-duck-anas-platyrhynchos
#18
Zhepeng Wang, Guohua Meng, Yun Bai, Ruifang Liu, Yu Du, Lihong Su
BACKGROUND: In birds, blue-green eggshell color (BGEC) is caused by biliverdin, a bile pigment derived from the degradation of heme and secreted in the eggshell by the shell gland. Functionally, BGEC might promote the paternal investment of males in the nest and eggs. However, little is known about its formation mechanisms. Jinding ducks (Anas platyrhynchos) are an ideal breed for research into the mechanisms, in which major birds lay BGEC eggs with minor individuals laying white eggs...
September 12, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28875070/dinosaur-origin-of-egg-color-oviraptors-laid-blue-green-eggs
#19
Jasmina Wiemann, Tzu-Ruei Yang, Philipp N Sander, Marion Schneider, Marianne Engeser, Stephanie Kath-Schorr, Christa E Müller, P Martin Sander
Protoporphyrin (PP) and biliverdin (BV) give rise to the enormous diversity in avian egg coloration. Egg color serves several ecological purposes, including post-mating signaling and camouflage. Egg camouflage represents a major character of open-nesting birds which accomplish protection of their unhatched offspring against visually oriented predators by cryptic egg coloration. Cryptic coloration evolved to match the predominant shades of color found in the nesting environment. Such a selection pressure for the evolution of colored or cryptic eggs should be present in all open nesting birds and relatives...
2017: PeerJ
https://www.readbyqxmd.com/read/28874192/plasma-metabolomic-study-in-chinese-patients-with-wet-age-related-macular-degeneration
#20
Dan Luo, Tingting Deng, Wei Yuan, Hui Deng, Ming Jin
BACKGROUND: Age-related macular degeneration (AMD) is a leading disease associated with blindness. It has a high incidence and complex pathogenesis. We aimed to study the metabolomic characteristics in Chinese patients with wet AMD by analyzing the morning plasma of 20 healthy controls and 20 wet AMD patients for metabolic differences. METHODS: We used ultra-high-pressure liquid chromatography and quadrupole-time-of-flight mass spectrometry for this analysis. The relationship of these differences with AMD pathophysiology was also assessed...
September 6, 2017: BMC Ophthalmology
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