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Biliverdin

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https://www.readbyqxmd.com/read/28500721/structural-and-vibrational-characterization-of-the-chromophore-binding-site-of-bacterial-phytochrome-agp1
#1
Aref Takiden, Francisco Velazquez-Escobar, Jovan Dragelj, Anna Lena Woelke, Ernst-Walter Knapp, Patrick Piwowarski, Franz Bart, Peter Hildebrandt, Maria Andrea Mroginski
Agp1 is a prototypical bacterial phytochrome from Agrobacterium fabrum harboring a biliverdin cofactor which reversibly photoconverts between a red-light-absorbing (Pr) and a far-red-light-absorbing (Pfr) states. The reaction mechanism involves the isomerization of the bilin-chromophore followed by large structural changes of the protein matrix that are coupled to protonation dynamics at the chromophore binding site. Histidines His250 and His280 participate in this process. Although the three-dimensional structure of Agp1 has been solved at high resolution, the precise position of hydrogen atoms and protonation pattern in the chromophore binding pocket has not been investigated yet...
May 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28499219/oxidant-and-anti-oxidant-status-in-common-brain-tumors-correlation-to-tp53-and-human-biliverdin-reductase
#2
Pinar Atukeren, Sena Oner, Oguz Baran, Rahsan Kemerdere, Bulent Eren, Ufuk Cakatay, Taner Tanriverdi
OBJECTIVE: To assess oxidant and antioxidant status in patients with common brain tumors; namely meningiomas, low-grade gliomas (LGG) and high-grade gliomas (HGG) and to compare with normal brain tissues. PATIENTS AND METHODS: Almost nine biomarkers were measured in 59 brain tumors obtained during surgery and 15 normal brain tissues that were collected during autopsy. Results were compared between two groups. RESULTS: In general, protein oxidation and lipid peroxidation increased while antioxidant capacity decreased significantly in tumors compared to the controls (p<0...
May 3, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28490767/biliverdin-reductase-inhibitors-did-not-improve-severe-unconjugated-hyperbilirubinemia-in-vivo
#3
Remco van Dijk, Sem J Aronson, Dirk R de Waart, Stan F van de Graaf, Suzanne Duijst, Jurgen Seppen, Ronald Oude Elferink, Ulrich Beuers, Piter J Bosma
We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit human and rat BVRA activity and 26 compounds were identified as BVRA inhibitors. Montelukast and Disulfiram were selected as potentially clinically applicable drugs and tested to reduce serum unconjugated bilirubin (UCB) levels in the Ugt1a1-deficient rat, a model for chronic unconjugated hyperbilirubinemia...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28481303/interaction-of-biliverdin-chromophore-with-near-infrared-fluorescent-protein-bphp1-fp-engineered-from-bacterial-phytochrome
#4
Olesya V Stepanenko, Olga V Stepanenko, Irina M Kuznetsova, Daria M Shcherbakova, Vladislav V Verkhusha, Konstantin K Turoverov
Near-infrared (NIR) fluorescent proteins (FPs) designed from PAS (Per-ARNT-Sim repeats) and GAF (cGMP phosphodiesterase/adenylate cyclase/FhlA transcriptional activator) domains of bacterial phytochromes covalently bind biliverdin (BV) chromophore via one or two Cys residues. We studied BV interaction with a series of NIR FP variants derived from the recently reported BphP1-FP protein. The latter was engineered from a bacterial phytochrome RpBphP1, and has two reactive Cys residues (Cys15 in the PAS domain and Cys256 in the GAF domain), whereas its mutants contain single Cys residues either in the PAS domain or in the GAF domain, or no Cys residues...
May 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28480786/ultraviolet-a1-irradiation-therapy-for-systemic-lupus-erythematosus
#5
H McGrath
Systemic lupus erythematosus (lupus, SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which bind to antigens and are deposited within tissues to fix complement, resulting in widespread systemic inflammation. The studies presented herein are consistent with hyperpolarized, adenosine triphosphate (ATP)-deficient mitochondria being central to the disease process. These hyperpolarized mitochondria resist the depolarization required for activation-induced apoptosis. The mitochondrial ATP deficits add to this resistance to apoptosis and also reduce the macrophage energy that is needed to clear apoptotic bodies...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28459399/-biliverdin-protects-the-isolated-lungs-from-ischemia-reperfusion-injury-via-anti-apoptosis
#6
Jieyun Sun, Peng Zhang, Xinying Yang, Di Xu, Bin Du, Junliang Chen, Minchen Wu, Qingfeng Pang
OBJECTIVE: To observe the effect of biliverdin (BV) on the lung ischemia/reperfusion injury (LIRI), and to investigate the mechanism of BV in treatment of LIRI. METHODS: Thirty-two male Sprague-Dawley (SD) rats were randomly divided into control group, LIRI group, glutathione (GSH) group and BV-treated group, with 8 rats in each group. The rat LIRI model was reproduced by isolated lung perfusion system. Fifteen minutes after perfusion balance, lungs of control group were perfused continuously for 90 minutes, and the lungs in other groups were reperfused for 90 minutes after 1-hour ischemia, while the perfusion was added 10 ?mol/L BV in BV-treated group and 4 mmol/L GSH in GSH group respectively...
January 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28421060/the-heme-metabolite-carbon-monoxide-facilitates-kshv-infection-by-inhibiting-tlr4-signaling-in-endothelial-cells
#7
Sara Botto, Jean K Gustin, Ashlee V Moses
Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi sarcoma (KS) and certain rare B cell lymphoproliferative disorders. KSHV infection of endothelial cells (EC) in vitro increases expression of the inducible host-encoded enzyme heme oxygenase-1 (HO-1), which is also strongly expressed in KS tumors. HO-1 catalyzes the rate-limiting step in the conversion of heme into iron, biliverdin and the gasotransmitter carbon monoxide (CO), all of which share anti-apoptotic, anti-inflammatory, pro-survival, and tumorigenic activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28412905/therapeutic-potential-of-heme-oxygenase-1-carbon-monoxide-system-against-ischemia-reperfusion-injury
#8
Yuanyuan Cheng, Jianhui Rong
BACKGROUND: Ischemia-reperfusion (I/R) injury causes the dysfunctions of different major organs, leading to morbidity and mortality on the global scale. Among a battery of therapeutic targets, the heme oxygenase-1 (HO-1)/carbon monoxide (CO) system has been evaluated for the development of new therapies against I/R injury. The enzyme HO-1 catalyzes the degradation of heme into three biologically active end products, namely biliverdin/bilirubin, CO and ferrous ion. Interestingly, CO is one of a few bioactive gaseous molecules with the capability of regulating inflammation, cell survival and growth...
April 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28412296/impact-of-higher-order-heme-degradation-products-on-hepatic-function-and-hemodynamics
#9
Raphael A Seidel, Thierry Claudel, Franziska A Schleser, Navin K Ojha, Matthias Westerhausen, Sandor Nietzsche, Christoph Sponholz, Frans Cuperus, Sina M Coldewey, Stefan H Heinemann, Georg Pohnert, Michael Trauner, Michael Bauer
BACKGROUND& AIMS: While, traditionally, biliverdin and bilirubin are considered end products of heme catabolism, there is evidence for further degradation to diverse bioactive products. As such, Z-BOX A and Z-BOX B arise upon oxidation with unknown implications for hepatocellular function and integrity. We studied the impact of Z-BOX A and B on hepatic functions and explored their alterations in health and cholestatic conditions. METHODS: Functional implications and mechanisms were investigated in rats, hepatocytic HepG2 and HepaRG cells, human immortalized hepatocytes, and isolated perfused livers...
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28401765/near-infrared-fluorescent-proteins-biosensors-and-optogenetic-tools-engineered-from-phytochromes
#10
Konstantin G Chernov, Taras A Redchuk, Evgeniya S Omelina, Vladislav V Verkhusha
Phytochrome photoreceptors absorb far-red and near-infrared (NIR) light and regulate light responses in plants, fungi, and bacteria. Their multidomain structure and autocatalytic incorporation of linear tetrapyrrole chromophores make phytochromes attractive molecular templates for the development of light-sensing probes. A subclass of bacterial phytochromes (BphPs) utilizes heme-derived biliverdin tetrapyrrole, which is ubiquitous in mammalian tissues, as a chromophore. Because biliverdin possesses the largest electron-conjugated chromophore system among linear tetrapyrroles, BphPs exhibit the most NIR-shifted spectra that reside within the NIR tissue transparency window...
April 12, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28389660/characteristics-of-the-heme-catabolic-pathway-in-mild-unconjugated-hyperbilirubinemia-and-their-associations-with-inflammation-and-disease-prevention
#11
Christine Mölzer, Marlies Wallner, Carina Kern, Anela Tosevska, René Zadnikar, Daniel Doberer, Rodrig Marculescu, Karl-Heinz Wagner
Heme catabolism exerts physiological functions that impact health through depressing inflammation. Upon reactive pathway progression, as in Gilbert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined. Based on lower inflammation and improved metabolic health reported for GS, inter-group differences in heme catabolism were explored. Therefore, a case-control study including 120 fasted, healthy, age- and gender matched subjects with/without GS, was conducted. Genetic expressions of HMOX-1 and BLVRA were measured...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28385652/hmus-from-yersinia-pseudotuberculosis-is-a-non-canonical-heme-degrading-enzyme-to-acquire-iron-from-heme
#12
Masato Onzuka, Yukari Sekine, Takeshi Uchida, Koichiro Ishimori, Shin-Ichi Ozaki
Some Gram-negative pathogens import host heme into the cytoplasm and utilize it as an iron source for their survival. We report here that HmuS, encoded by the heme utilizing system (hmu) locus, cleaves the protoporphyrin ring to release iron from heme. A liquid chromatography/mass spectrometry analysis revealed that the degradation products of this reaction are two biliverdin isomers that result from transformation of a verdoheme intermediate. This oxidative heme degradation by HmuS required molecular oxygen and electrons supplied by either ascorbate or NADPH...
April 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28380331/near-infrared-fluorescent-protein-irfp713-as-a-reporter-protein-for-optogenetic-vectors-a-transgenic-cre-reporter-rat-and-other-neuronal-studies
#13
Christopher T Richie, Leslie R Whitaker, Keith W Whitaker, Julie Necarsulmer, Heather A Baldwin, Yajun Zhang, Lowella Fortuno, Josh J Hinkle, Pyry Koivula, Mark J Henderson, Wenzhi Sun, Kai Wang, Jeffrey C Smith, Jim Pickel, Na Ji, Bruce T Hope, Brandon K Harvey
BACKGROUND: The use of genetically-encoded fluorescent reporters is essential for the identification and observation of cells that express transgenic modulatory proteins. Near-infrared (NIR) fluorescent proteins have superior light penetration through biological tissue, but are not yet widely adopted. NEW METHOD: Using the near-infrared fluorescent protein, iRFP713, improves the imaging resolution in thick tissue sections or the intact brain due to the reduced light-scattering at the longer, NIR wavelengths used to image the protein...
April 2, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28347842/potential-role-of-heme-metabolism-in-the-inducible-expression-of-heme-oxygenase-1
#14
Aka-Aki Takeda, Machiko Sasai, Yuka Adachi, Keiko Ohnishi, Jun-Ichi Fujisawa, Shingo Izawa, Shigeru Taketani
BACKGROUND: The degradation of heme significantly contributes to cytoprotective effects against oxidative stress and inflammation. The enzyme heme oxygenase-1 (HO-1), involved in the degradation of heme, forms carbon monoxide (CO), ferrous iron, and bilirubin in conjunction with biliverdin reductase, and is induced by various stimuli including oxidative stress and heavy metals. We examined the involvement of heme metabolism in the induction of HO-1 by the inducers sulforaphane and sodium arsenite...
March 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28345551/biliverdin-protects-the-isolated-rat-lungs-from-ischemia-reperfusion-injury-via-antioxidative-anti-inflammatory-and-anti-apoptotic-effects
#15
Wen-Fang Tian, Ping Weng, Qiong Sheng, Jun-Liang Chen, Peng Zhang, Ji-Ru Zhang, Bin Du, Min-Chen Wu, Qing-Feng Pang, Jian-Jun Chu
BACKGROUND: Biliverdin (BV) has a protective role against ischemia-reperfusion injury (IRI). However, the protective role and potential mechanisms of BV on lung IRI (LIRI) remain to be elucidated. Thus, we aimed to investigate the protective role and potential mechanisms of BV on LIRI. METHODS: Lungs were isolated from Sprague-Dawley rats to establish an ex vivo LIRI model. After an initial 15 min stabilization period, the isolated lungs were subjected to ischemia for 60 min, followed by 90 min of reperfusion with or without BV treatment...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28343921/cell-growth-of-immortalized-arachnoid-cells-in-the-presence-of-fibroblasts-and-blood-products
#16
Catherine A Miller, Eric A Hansen, Cornelius H Lam
OBJECT: The pathophysiology of non-obstructive hydrocephalus involves alteration in cerebrospinal fluid (CSF) pathways. The exact mechanism is unknown, but as arachnoid CSF egress is a major route of CSF removal, damage or alteration to the growth of arachnoid cells may influence the rate of CSF absorption. We investigated the effect of soluble factors secreted by fibroblasts and the presence of blood products on arachnoid cell growth. METHODS: An immortalized arachnoid cell line was developed and cells were grown on semipermeable membranes in a culture chamber...
March 23, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28335416/supplementation-with-phycocyanobilin-citrulline-taurine-and-supranutritional-doses-of-folic-acid-and-biotin-potential-for-preventing-or-slowing-the-progression-of-diabetic-complications
#17
Mark F McCarty
Oxidative stress, the resulting uncoupling of endothelial nitric oxide synthase (eNOS), and loss of nitric oxide (NO) bioactivity, are key mediators of the vascular and microvascular complications of diabetes. Much of this oxidative stress arises from up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. Phycocyanobilin (PhyCB), the light-harvesting chromophore in edible cyanobacteria such as spirulina, is a biliverdin derivative that shares the ability of free bilirubin to inhibit certain isoforms of NADPH oxidase...
March 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28285405/the-effects-of-blood-and-blood-products-on-the-arachnoid-cell
#18
Eric A Hansen, Liudmila Romanova, Christopher Janson, Cornelius H Lam
After traumatic brain injury (TBI), large amounts of red blood cells and hemolytic products are deposited intracranially creating debris in the cerebrospinal fluid (CSF). This debris, which includes heme and bilirubin, is cleared via the arachnoid granulations and lymphatic systems. However, the mechanisms by which erythrocytes and their breakdown products interfere with normal CSF dynamics remain poorly defined. The purpose of this study was to model in vitro how blood breakdown products affect arachnoid cells at the CSF-blood barrier, and the extent to which the resorption of CSF into the venous drainage system is mechanically impaired following TBI...
March 11, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28257621/the-heme-oxygenase-system-in-hematological-malignancies
#19
Giovanni Li Volti, Daniele Tibullo, Luca Vanella, Cesarina Giallongo, Francesco Di Raimondo, Stefano Forte, Michelino Di Rosa, Salvatore Santo Signorelli, Ignazio Barbagallo
SIGNIFICANCE: Several lines of evidence suggest that hematological malignancies exhibit an altered redox balance homeostasis that can lead to the activation of various survival pathways that, in turn, lead to the progression of disease and chemoresistance. Among these pathways, the heme oxygenase-1 (HO-1) pathway is likely to play a major role. HO catalyzes the enzymatic degradation of heme with the simultaneous release of carbon monoxide (CO), ferrous iron (Fe(2+)), and biliverdin. This review focuses on the role of HO-1 in various hematological malignancies and the possibility of exploiting such targets to improve the outcome of well-established chemotherapeutic regimens...
May 19, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28219651/ho1-and-wnt-expression-is-independently-regulated-in-female-mice-brains-following-permanent-ischemic-brain-injury
#20
Jatin Tulsulkar, Alicia Ward, Zahoor A Shah
A gender difference in stroke is observed throughout epidemiologic studies, pathophysiology, treatment and outcomes. We investigated the neuroprotective role of hemeoxygenase (HO) enzyme, which catabolizes free heme to bilirubin, carbon monoxide and biliverdin in the female brain after permanent ischemia. We have previously reported in male mice that genetic deletion of HO1 exacerbates the brain damage after permanent ischemia, and the mechanism of neuroprotection is dependent on the HO1/Wnt pathway; however, the role of HO1/Wnt mediated neuroprotection in the female brain is yet to be investigated...
May 1, 2017: Brain Research
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