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vitamin c serum, skin

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https://www.readbyqxmd.com/read/28697823/-clinical-feature-and-genetic-analysis-of-a-family-affected-by-congenital-bile-acid-synthesis-defect-type-2-identification-of-2-novel-mutations-in-akr1d1-gene
#1
Ying Cheng, Li Guo, Mei Deng, Yuan-Zong Song
Congenital bile acid synthesis defect type 2 (CBAS2) is an autosomal recessive disorder caused by biallelic mutations of AKR1D1 gene, which encodes the Δ4-3-oxo-steroid 5β-reductase. Cholestatic jaundice is the main clinical manifestation, accompanied by malabsorption of fat and fat-soluble vitamins. This paper reported the clinical and genetic features of a CBAS2 patient definitely diagnosed by AKR1D1 genetic analysis. An 8-month-old male infant was referred to the hospital with the complaint of jaundiced skin and sclera over 7 months...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28684064/protective-role-of-vitamin-e-preconditioning-of-human-dermal-fibroblasts-against-thermal-stress-in-vitro
#2
Hira Butt, Azra Mehmood, Muhammad Ali, Saba Tasneem, Muhammad Sohail Anjum, Moazzam N Tarar, Shaheen N Khan, Sheikh Riazuddin
AIMS: Oxidative microenvironment of burnt skin restricts the outcome of cell based therapies of thermal skin injuries. The aim of this study was to precondition human dermal fibroblasts with an antioxidant such as vitamin E to improve their survival and therapeutic abilities in heat induced oxidative in vitro environment. MAIN METHODS: Fibroblasts were treated with 100μM vitamin E for 24h at 37°C followed by heat shock for 10min at 51°C in fresh serum free medium...
July 3, 2017: Life Sciences
https://www.readbyqxmd.com/read/28611427/canine-leishmaniasis-progression-is-associated-with-vitamin-d-deficiency
#3
A Rodriguez-Cortes, C Martori, A Martinez-Florez, A Clop, M Amills, J Kubejko, J Llull, J M Nadal, J Alberola
The relationship between vitamin D deficiency and the risk of suffering from a plethora of health disorders, ranging from autoimmune processes to infectious diseases has been widely described. Nonetheless, the potential role of vitamin D in visceral leishmaniasis remains uncharacterized. In the Mediterranean basin, where the dog is leishmania's main peri-domestic reservoir, control measures against the canine disease have shown beneficial effects on the incidence of human leishmaniasis. In this study, we measured the vitamin D levels in serum samples from a cohort of 68 healthy and disease dogs from a highly endemic area and we have also studied the relationship of these levels with parasitological and immunological parameters...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28591686/the-role-of-topically-applied-l-ascorbic-acid-in-ex-vivo-examination-of-burn-injured-human-skin
#4
Anna Pielesz, Dorota Biniaś, Rafał Bobiński, Ewa Sarna, Jadwiga Paluch, Wioletta Waksmańska
Wound treatment and healing is complex and is comprised of an elaborate set of processes including cellular, spectroscopic and biochemical ones as well as the "reaction" of local tissue to thermal injury. Vitamin C as l-ascorbic acid (LA) prevents injurious effects of oxidants because it reduces reactive oxygen species to stable molecules, it becomes oxidized to the short-lived ascorbyl radical. As a result, antioxidant treatment may contribute to minimizing injury in burn patients. The aim of this study is to assess changes in molecular structure of collagen extracted from human epidermis burn wound scab during incubation of the epidermis in l-ascorbic acid solution...
May 30, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28589636/25-hydroxyvitamin-d3-and-its-c-3-epimer-are-elevated-in-the-skin-and-serum-of-skh-1-mice-supplemented-with-dietary-vitamin-d3
#5
Matthew D Teegarden, Amanda R Campbell, Jessica L Cooperstone, Kathleen L Tober, Steven J Schwartz, Tatiana M Oberyszyn
SCOPE: UV exposure is a risk factor for keratinocyte carcinoma (KC) while critical for endogenous vitamin D production. We investigated dietary modulation of skin and serum 25-hydroxyvitamin D3 (25OHD3 ) and its C-3 epimer (C3epi) in a mouse model of KC. C3epi is an under-investigated metabolite of vitamin D with respect to its biological implications. METHODS AND RESULTS: Male and female Skh-1 mice were supplemented with 25, 150 or 1000 IU/kg diet vitamin D3 for 25 weeks, with some exposed to UV light...
June 7, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28459987/vitamin-d-and-fracture-risk-in-early-childhood-a-case-control-study
#6
Laura N Anderson, Sze Wing Heong, Yang Chen, Kevin E Thorpe, Khosrow Adeli, Andrew Howard, Etienne Sochett, Catherine S Birken, Patricia C Parkin, Jonathon L Maguire
The objective of this study was to evaluate the association of vitamin D intake and serum levels with fracture risk in children under 6 years of age. A case-control study was conducted in Toronto, Ontario, Canada. Cases were recruited from the fracture clinic at the Hospital for Sick Children, and matched controls were obtained from the TARGet Kids! primary-care research network. Controls were matched to cases on age, sex, height, and season. Fracture risk was estimated from conditional logistic regression, with adjustment for skin type, fracture history, waist circumference, outdoor free play, neighborhood income, soda consumption, and child's birth weight...
April 28, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28421711/vitamin-d-status-of-white-pregnant-women-and-infants-at-birth-and-4%C3%A2-months-in-north-west-england-a-cohort-study
#7
A J B Emmerson, K Dockery, M Z Mughal, S A Roberts, C L Tower, J L Berry
The prevalence of vitamin D deficiency in pregnant white-skinned women (WSW) and their infants has not been investigated at northern latitudes in a developed county. A 2-year observational cohort study was undertaken in the North West of England to determine 25-hydroxyvitamin D (25OHD) levels in WSW and their infants during pregnancy and 4 months postdelivery and to explore factors associated with these levels. Nutritional and lifestyle questionnaires were completed and 25OHD levels measured at 28 weeks and 4 months postdelivery...
April 18, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28294587/vitamin-d-levels-and-allergic-diseases-an-italian-cross-sectional-multicenter-survey
#8
C Lombardi, G Passalacqua
Background. During the two last decades, the interest in the role of Vitamin D (VD) in allergic disease has increased. Apart from the well-known actions of VD in bone metabolism, recent studies suggested its possible role as an immune-modulator in allergy. Objective. This study, conducted over the Italian territory, evaluated the possible correlations between VD serum level and diagnosed allergic diseases (rhinitis / asthma, food allergy, atopic dermatitis). Thus, VD was assessed in patients with physician-diagnosed allergic diseases...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28287422/prevalence-of-vitamin-d-deficiency-and-its-associations-with-skin-color-in-pregnant-women-in-the-first-trimester-in-a-sample-from-switzerland
#9
Aline Richard, Sabine Rohrmann, Katharina C Quack Lötscher
Vitamin D deficiency in pregnancy has negative clinical consequences, such as associations with glucose intolerance, and has been shown to be distributed differently in certain ethnic groups. In some countries, a difference in the rate of vitamin D deficiency was detected in pregnant women depending on their skin color. We examined the prevalence of vitamin D deficiency (<20 ng/mL) in women in early pregnancy in Switzerland and evaluated the association of skin color with vitamin D deficiency. In a single-center cohort study, the validated Fitzpatrick scale and objective melanin index were used to determine skin color...
March 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28012019/birmingham-epidermolysis-severity-score-and-vitamin-d-status-are-associated-with-low-bmd-in-children-with-epidermolysis-bullosa
#10
G Rodari, S Guez, F Manzoni, K K Chalouhi, E Profka, S Bergamaschi, S Salera, G Tadini, F M Ulivieri, A Spada, C Giavoli, S Esposito
Bone status impairment represents a complication of generalized forms of epidermolysis bullosa (EB); however, the prevalence and the main determinants of this event in localized forms remain poorly defined. Birmingham epidermolysis bullosa severity (BEBS) score and 25-hydroxyvitamin D levels are strongly associated with low bone mass, suggesting that vitamin D may play a potential beneficial role in bone health. Further longitudinal studies are needed in order to confirm this hypothesis. INTRODUCTION: Bone status impairment represents a complication of generalized forms of EB; thus, we aimed to estimate the prevalence of low bone mass, to examine mineralization differences in various EB subtypes and to identify the most important determinants of bone impairment in children with either generalized or localized EB...
April 2017: Osteoporosis International
https://www.readbyqxmd.com/read/27926978/potential-blood-biomarkers-in-chronic-spontaneous-urticaria
#11
REVIEW
P Kolkhir, F André, M K Church, M Maurer, M Metz
Chronic spontaneous urticaria (CSU) is a mast cell-driven disease that is defined as the recurrence of weals, angioedema or both for > 6 weeks due to known or unknown causes. As of yet, disease diagnosis is purely clinical. Objective tools are needed to monitor the activity of CSU and the efficacy of treatment. Recently, several reports have suggested that blood parameters may be considered as potential disease-related biomarkers. Here, we reviewed available literature on blood biomarkers for CSU diagnosis, activity monitoring, duration, patient subgroup allocation or response to treatment...
January 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27894590/preconditioning-with-azadirachta-indica-ameliorates-cardiorenal-dysfunction-through-reduction-in-oxidative-stress-and-extracellular-signal-regulated-protein-kinase-signalling
#12
Temidayo Olutayo Omóbòwálé, Ademola Adetokunbo Oyagbemi, Olumuyiwa Abiola Adejumobi, Eguonor Vivian Orherhe, Adetayo Sadudeen Amid, Adeolu Alex Adedapo, Helen Olubukola Nottidge, Momoh Audu Yakubu
BACKGROUND: Azadirachta indica is widely distributed in Africa, Asia and other tropical parts of the world. A. indica (AI) is traditionally used for the treatment of several conditions including cancer, hypertension, heart diseases and skin disorders. Intestinal ischaemia-reperfusion is a common pathway for many diseases and may lead to multiple organ dysfunction syndrome and death. OBJECTIVE: In this study, we investigated the ameliorative effects of AI on intestinal ischaemia-reperfusion injury-induced cardiorenal dysfunction...
October 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27824059/vitamin-d-deficiency-in-individuals-with-a-spinal-cord-injury-a-literature-review
#13
REVIEW
J L Flueck, C Perret
STUDY DESIGN: Literature review of studies investigating vitamin D status in individuals with a spinal cord injury (SCI). OBJECTIVES: Prevalence of vitamin D deficiency seems to be high in the general population. Little is known regarding such a deficiency in individuals with a SCI. This review aimed to examine the literature that investigated vitamin D status in this population. SETTING: Switzerland. METHODS: A literature review was performed to investigate the prevalence of vitamin D deficiency in individuals with a SCI and to determine the factors leading to deficiency...
May 2017: Spinal Cord
https://www.readbyqxmd.com/read/27793182/homocysteine-metabolism-in-children-and-adolescents-with-epidermolysis-bullosa
#14
Rachele De Giuseppe, Greta Venturelli, Sophie Guez, Simona Salera, Claudia De Vita, Dario Consonni, Cinzia Dellanoce, Fabrizia Bamonti, Gabriella Chiarelli, Francesca Manzoni, Rita Maiavacca, Susanna Esposito
BACKGROUND: Epidermolysis bullosa (EB) belongs to a family of rare heterogeneous, genetic disorders characterized by blistering of the skin and mucous membranes in response to minor mechanical trauma. The involvement of the oral mucosa and oesophagus stenosis is suggested to be responsible for severe nutritional deficiencies, but few studies have till now considered this aspect. This observational study aimed to evaluate homocysteine status in children and adolescents with EB by assessing total plasma homocysteine (tHcy) and metabolically related vitamins (B6, B12, folate) concentrations...
October 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27693095/clinical-practice-guidelines-for-vitamin-d-in-the-united-arab-emirates
#15
Afrozul Haq, Sunil J Wimalawansa, Pawel Pludowski, Fatme Al Anouti
In the UAE and the Gulf region in general, there are several intricate public health issues in the context of vitamin D deficiency that needs to be addressed. Changes in lifestyle such as diet, lack of exercise, cultural habits, avoiding sun exposure due to excessive heat, and other risk factors predispose those who live in GULF countries, such as Emiratis likely to becoming vitamin D deficient. Consequently, the prevalence of vitamin D deficiency is high, and new guidelines are needed to overcome this major public health issue...
September 28, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27683872/lifestyle-and-other-factors-explain-one-half-of-the-variability-in-the-serum-25-hydroxyvitamin-d-response-to-cholecalciferol-supplementation-in-healthy-adults
#16
Judy R Rees, Leila A Mott, Elizabeth L Barry, John A Baron, Roberd M Bostick, Jane C Figueiredo, Robert S Bresalier, Douglas J Robertson, Janet L Peacock
BACKGROUND: Many factors have been associated with serum 25-hydroxyvitamin D [25(OH)D] concentrations in observational studies, with variable consistency. However, less information is available on factors affecting the magnitude of changes in serum 25(OH)D resulting from vitamin D supplementation. OBJECTIVE: This study aimed to identify factors associated with the serum 25(OH)D response to supplementation with 1000 IU cholecalciferol/d during the first year of a large, multicenter, randomized, placebo-controlled colorectal adenoma chemoprevention trial...
November 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27566444/interplay-between-membrane-lipid-peroxidation-and-photoproduct-formation-in-the-ultraviolet-a-induced-phototoxicity-of-vemurafenib-in-skin-keratinocytes
#17
Ana Teixeira, Patrice Morlière, João Ferreira, Marie-Alix Conte, Antoine Galmiche, Jean-Claude Mazière, René Santus, Paulo Filipe
According to some authors, the phototoxic response to ultraviolet A (UVA) of patients treated with vemurafenib (VB) may involve VB metabolites. However, the production of singlet oxygen and free radicals and photoproduct formation upon UVA light absorption by the lipophilic VB have been demonstrated. This work is aimed at determining the contribution of reactive oxygen species (ROS), lipid photoperoxidation, and VB photochemistry in the UVA-induced photocytotoxicity in NCTC 2544 keratinocytes. The potent membrane lipid peroxidation effectiveness of VB-photosensitization has been proved by the observation of an effective photohemolysis accompanied by thiobarbituric reactive substances (TBARS) formation in 2% red blood cell (RBC) suspensions...
December 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27517618/higher-maternal-serum-concentrations-of-nicotinamide-and-related-metabolites-in-late-pregnancy-are-associated-with-a-lower-risk-of-offspring-atopic-eczema-at-age-12-months
#18
S El-Heis, S R Crozier, S M Robinson, N C Harvey, C Cooper, H M Inskip, K M Godfrey
BACKGROUND: Evidence that atopic eczema partly originates in utero is increasing, with some studies linking the risk of developing the condition with aspects of maternal diet during pregnancy. Nicotinamide, a naturally occurring nutrient that is maintained through the dietary intakes of vitamin B3 and tryptophan, has been used in the treatment of some skin conditions including atopic eczema. OBJECTIVE: To examine the relation of maternal serum concentrations of nicotinamide and related tryptophan metabolites to the risk of atopic eczema in the offspring...
October 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27264092/vitamin-d-supplementation-causes-a-decrease-in-blood-cholesterol-in-professional-rowers
#19
RANDOMIZED CONTROLLED TRIAL
Zbigniew Jastrzebski, Jakub Kortas, Katarzyna Kaczor, Jedrzej Antosiewicz
In the skin vitamin D3 is synthesized from cholesterol, which leaves the question whether a feedback mechanism controlling the level of blood cholesterol exists. Here we investigate the effects of vitamin D3 supplementation on serum lipids in professional rowers. The rowers were divided into two groups following the same training schedule for 4 wk: one received placebo (TP) while the second received 5,000 IU of vitamin D3 every day (TD3). Plasma total antioxidant status, total triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL)-cholesterol (HDL-C), low-density lipoprotein (LDL)-cholesterol (LDL-C) and 25-hydroxyvitamin D (25-OH-D3) were determined in pre- and post-intervention...
2016: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/27212156/peripheral-blood-regulatory-t-cell-measurements-correlate-with-serum-vitamin-d-level-in-patients-with-psoriasis
#20
C Mattozzi, G Paolino, M Salvi, L Macaluso, C Luci, S Morrone, S Calvieri, A G Richetta
OBJECTIVE: Vitamin D is the precursor of a hormone (1,25-dihydroxyvitamin D3), which has many biological effects in the skin. The immune modulator properties of vitamin D are mediated in part through effects on regulatory T cells (T-reg). Currently, in psoriasis, the relationship between vitamin D and T-reg has not well elucidated. We assess whether vitamin D status is correlated with circulating T-reg in patients affected by psoriasis and if there is a correlation with the severity of the disease evaluated with Psoriasis Area Severity Index (PASI) score...
May 2016: European Review for Medical and Pharmacological Sciences
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