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vitamin c serum, skin

Afrozul Haq, Sunil J Wimalawansa, Pawel Pludowski, Fatme Al Anouti
In the UAE and the Gulf region in general, there are several intricate public health issues in the context of vitamin D deficiency that needs to be addressed. Changes in lifestyle such as diet, lack of exercise, cultural habits, avoiding sun exposure due to excessive heat, and other risk factors predispose those who live in GULF countries, such as Emiratis likely to becoming vitamin D deficient. Consequently, the prevalence of vitamin D deficiency is high, and new guidelines are needed to overcome this major public health issue...
September 28, 2016: Journal of Steroid Biochemistry and Molecular Biology
Judy R Rees, Leila A Mott, Elizabeth L Barry, John A Baron, Roberd M Bostick, Jane C Figueiredo, Robert S Bresalier, Douglas J Robertson, Janet L Peacock
BACKGROUND: Many factors have been associated with serum 25-hydroxyvitamin D [25(OH)D] concentrations in observational studies, with variable consistency. However, less information is available on factors affecting the magnitude of changes in serum 25(OH)D resulting from vitamin D supplementation. OBJECTIVE: This study aimed to identify factors associated with the serum 25(OH)D response to supplementation with 1000 IU cholecalciferol/d during the first year of a large, multicenter, randomized, placebo-controlled colorectal adenoma chemoprevention trial...
September 28, 2016: Journal of Nutrition
A Teixeira, P Morlière, J Ferreira, M-A Conte, A Galmiche, J-C Mazière, R Santus, P Filipe
According to some authors, the phototoxic response to UVA of patients treated with vemurafenib (VB) may involve VB metabolites. However, the production of singlet oxygen and free radicals and photoproduct formation upon UVA light absorption by the lipophilic VB have been demonstrated. This works is aimed at determining the contribution of reactive oxygen species (ROS), lipid photoperoxidation and VB photochemistry in the UVA-induced photocytotoxicity in 2544 NCTC keratinocytes. The potent membrane lipid peroxidation effectiveness of VB-photosensitisation has been proved by the observation of an effective photohaemolysis accompanied by thiobarbituric reactive substances (TBARS) formation in 2% red blood cell (RBC) suspensions...
August 26, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
S El-Heis, S R Crozier, S M Robinson, N C Harvey, C Cooper, H M Inskip, K M Godfrey
BACKGROUND: Evidence that atopic eczema partly originates in utero is increasing, with some studies linking the risk of developing the condition with aspects of maternal diet during pregnancy. Nicotinamide, a naturally occurring nutrient that is maintained through the dietary intakes of vitamin B3 and tryptophan, has been used in the treatment of some skin conditions including atopic eczema. OBJECTIVE: To examine the relation of maternal serum concentrations of nicotinamide and related tryptophan metabolites to the risk of atopic eczema in the offspring...
October 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Zbigniew Jastrzebski, Jakub Kortas, Katarzyna Kaczor, Jedrzej Antosiewicz
In the skin vitamin D3 is synthesized from cholesterol, which leaves the question whether a feedback mechanism controlling the level of blood cholesterol exists. Here we investigate the effects of vitamin D3 supplementation on serum lipids in professional rowers. The rowers were divided into two groups following the same training schedule for 4 wk: one received placebo (TP) while the second received 5,000 IU of vitamin D3 every day (TD3). Plasma total antioxidant status, total triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL)-cholesterol (HDL-C), low-density lipoprotein (LDL)-cholesterol (LDL-C) and 25-hydroxyvitamin D (25-OH-D3) were determined in pre- and post-intervention...
2016: Journal of Nutritional Science and Vitaminology
C Mattozzi, G Paolino, M Salvi, L Macaluso, C Luci, S Morrone, S Calvieri, A G Richetta
OBJECTIVE: Vitamin D is the precursor of a hormone (1,25-dihydroxyvitamin D3), which has many biological effects in the skin. The immune modulator properties of vitamin D are mediated in part through effects on regulatory T cells (T-reg). Currently, in psoriasis, the relationship between vitamin D and T-reg has not well elucidated. We assess whether vitamin D status is correlated with circulating T-reg in patients affected by psoriasis and if there is a correlation with the severity of the disease evaluated with Psoriasis Area Severity Index (PASI) score...
May 2016: European Review for Medical and Pharmacological Sciences
Payam Peymani, Saied Ghavami, Behzad Yeganeh, Reza Tabrizi, Siamak Sabour, Bita Geramizadeh, Mohammad Reza Fattahi, Seyed Mehdi Ahmadi, Kamran B Lankarani
BACKGROUND: Hepatitis C virus infection frequently leads to chronic hepatitis C which may progress to cirrhosis and can be ended to hepatocellular carcinoma. This study aimed to investigate the effect of Anthropometric Parameters, Vit D3, Thyroid Function, Ferritin and Biochemistry Parameters in patients chronically infected with HCV with non-response criteria which was treated by chloroquine. METHODS: This study was the continuation of our previous investigation with a triple-blind method in a randomized controlled pilot study...
2016: Acta Bio-medica: Atenei Parmensis
Olumuyiwa Owolabi, Schadrac Agbla, Patrick Owiafe, Simon Donkor, Toyin Togun, Abdou K Sillah, Martin O C Ota, Jayne S Sutherland
BACKGROUND: Vitamin D is essential in the host defence against tuberculosis (TB) as an immune modulator. The aim of this study was to determine the level of 25-hydroxyvitamin D (25 (OH) D) from adult TB index cases before and after treatment and their exposed household contacts (HHC) in The Gambia. METHODS: Serum from adult index TB cases and their TB-exposed household contacts (HHC) was analysed for 25(OH) D and Vitamin D binding protein (VDBP) concentrations. Tuberculin skin test (TST) status was used as a measure of Mycobacterium tuberculosis (Mtb) infectivity in the HHC...
May 2016: Tuberculosis
S Azarpeykan, K E Dittmer, E K Gee, J C Marshall, J Wallace, P Elder, E Acke, K G Thompson
The aims of the study were to determine the effect of season and blanketing on vitamin D synthesis in horses and examine the interaction between vitamin D and other analytes involved in calcium homeostasis. Twenty-one healthy horses at pasture were included; 5 were covered with standard horse blankets including neck rugs. Blood samples were collected for 13 mo and analyzed for 25-hydroxyvitamin D2 (25OHD2) and 25-hydroxyvitamin D3 (25OHD3), 1,25-dihydroxyvitamin D (1,25[OH]2D), ionized calcium (iCa), total calcium (tCa), phosphorus (P), total magnesium (tMg), and parathyroid hormone (PTH)...
July 2016: Domestic Animal Endocrinology
Susana Cubillos, Nadine Krieg, Johannes Norgauer
BACKGROUND: Psoriasis, a chronic skin disease with or without joint inflammation, has increased circulating proinflammatory cytokine levels. Vitamin D is involved in calcium homeostasis, bone formation, osteoclastogenesis and osteoclast activity, as well as regulation of immune response. We aimed to study osteoclast differentiation and cytokine secretion of peripheral blood mononuclear cells (PBMCs) from patients with psoriasis vulgaris and psoriatic arthritis, in response to 1,25(OH)2D3...
2016: PloS One
Pameli Datta, Peter A Philipsen, Peter Olsen, Bibi Petersen, Peter Johansen, Niels Morling, Hans C Wulf
Vitamin D influences skeletal health as well as other aspects of human health. Even when the most obvious sources of variation such as solar UVB exposure, latitude, season, clothing habits, skin pigmentation and ethnicity are selected for, variation in the serum 25-hydroxy vitamin D (25(OH)D) response to UVB remains extensive and unexplained. Our study assessed the inter-personal variation in 25(OH)D response to UVR and the maximal obtainable 25(OH)D level in 22 healthy participants (220 samples) with similar skin pigmentation during winter with negligible ambient UVB...
April 2016: Photochemical & Photobiological Sciences
S Karras, S A Paschou, E Kandaraki, P Anagnostis, C Annweiler, B C Tarlatzis, B W Hollis, W B Grant, D G Goulis
Despite high levels of sunshine, maternal hypovitaminosis D during pregnancy is prevalent in the Mediterranean region. The aim of this study is to systematically review trials that investigated vitamin D concentrations during pregnancy in this region, in order to determine predictors of hypovitaminosis D and explain this phenomenon. After applying inclusion/exclusion criteria, 15 studies were entered into the systematic review involving 2649 pregnant women and 820 neonates. The main outcome was maternal vitamin D status, assessed by serum 25-hydroxy-vitamin D (25(OH)D) concentrations...
September 2016: European Journal of Clinical Nutrition
Vincent M Brandenburg, Rafael Kramann, Hansjörg Rothe, Nadine Kaesler, Joanna Korbiel, Paula Specht, Sophia Schmitz, Thilo Krüger, Jürgen Floege, Markus Ketteler
BACKGROUND: Calcific uraemic arteriolopathy (CUA, calciphylaxis) is a rare disease predominantly in dialysis patients and associated with high mortality. Painful skin ulcerations and calcification of cutaneous arterioles characterize calciphylaxis. METHODS: We established an observational, Internet-based registry allowing online notification for all German CUA cases. The registry recorded data about patient characteristics, biochemistry and therapies. Blood samples were stored in a central biobank...
January 29, 2016: Nephrology, Dialysis, Transplantation
Katrina J Allen, Mary Panjari, Jennifer J Koplin, Anne-Louise Ponsonby, Peter Vuillermin, Lyle C Gurrin, Ronda Greaves, Natalie Carvalho, Kim Dalziel, Mimi L K Tang, Katherine J Lee, Melissa Wake, Nigel Curtis, Shyamali C Dharmage
INTRODUCTION: Postnatal vitamin D supplementation may be associated with a reduction in IgE-mediated food allergy, lower respiratory tract infections and improved bone health. Countries in the Northern hemisphere recommend universal infant vitamin D supplementation to optimise early vitamin D levels, despite the absence of large trials proving safety or efficacy for any disease outcome. With the aim of determining the clinical and cost-effectiveness of daily vitamin D supplementation in breastfed infants from age 6-8 weeks to 12 months of age, we have started a double-blind, randomised, placebo-controlled trial of daily 400 IU vitamin D supplementation during the first year of life, VITALITY...
2015: BMJ Open
Sonia Paco, Teresa Casserras, Maria Angels Rodríguez, Cristina Jou, Montserrat Puigdelloses, Carlos I Ortez, Jordi Diaz-Manera, Eduardo Gallardo, Jaume Colomer, Andrés Nascimento, Susana G Kalko, Cecilia Jimenez-Mallebrera
BACKGROUND: Collagen VI related myopathies encompass a range of phenotypes with involvement of skeletal muscle, skin and other connective tissues. They represent a severe and relatively common form of congenital disease for which there is no treatment. Collagen VI in skeletal muscle and skin is produced by fibroblasts. AIMS & METHODS: In order to gain insight into the consequences of collagen VI mutations and identify key disease pathways we performed global gene expression analysis of dermal fibroblasts from patients with Ullrich Congenital Muscular Dystrophy with and without vitamin C treatment...
2015: PloS One
Johanna E C Van der Walt, Werner Sinclair
BACKGROUND: Associations between vitamin D deficiency and a broad variety of independent diseases, including several bone diseases, various types of cancer, autoimmune diseases, hypertension, and cardiovascular disease, have been suggested. It is therefore important to detect and treat vitamin D deficiency in high-risk groups. Because patients with albinism (PWA) practice a policy of strict sun avoidance, they may be at risk for low levels of vitamin D. OBJECTIVES: This study was conducted in patients attending dermatology clinics in the Free State, South Africa, to determine sun avoidance behavior in the patient population and to compare 25-hydroxyvitamin D (25[OH]D) levels in PWA with those in normally pigmented Black patients attending the same clinics...
September 2016: International Journal of Dermatology
Andrzej T Slominski, Tae-Kang Kim, Wei Li, Arnold Postlethwaite, Elaine W Tieu, Edith K Y Tang, Robert C Tuckey
To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we analyzed samples of human serum and epidermis, and pig adrenals for the presence of intermediates and products of these pathways. We extracted human epidermis from 13 individuals and sera from 13 individuals and analyzed them by LC/qTOF-MS alongside the corresponding standards. Pig adrenal glands were also analyzed for these steroids and secosteroids...
October 8, 2015: Scientific Reports
Catherine S Birken, Gerald Lebovic, Laura N Anderson, Brian W McCrindle, Muhammad Mamdani, Sharmilaa Kandasamy, Marina Khovratovich, Patricia C Parkin, Jonathon L Maguire
Vitamin D is associated with established cardiovascular risk factors such as low density lipoprotein (LDL) in adults. It is unknown whether these associations are present in early childhood. To determine whether serum 25-hydroxyvitamin D (25(OH)D) is associated with serum non-high density lipoprotein (non-HDL) cholesterol during early childhood we conducted a cross-sectional study of children aged 1 to 5 years. Healthy children were recruited through the TARGet Kids! practice based research network from 2008-2011 (n=1,961)...
2015: PloS One
L Chandrashekar, G R Krishna Kumarit, M Rajappa, G Revathy, M Munisamy, D M Thappa
Psoriasis is a T-helper-1 (Th1)/Th17-mediated chronic inflammatory skin disease, characterised by hyperproliferation of keratinocytes. Psoriasis and cardiovascular disease share similar pathogenic mechanisms such as vascular endothelial cell dysfunction, oxidative stress and metabolic syndrome. 25-hydroxy vitamin D is an immune-regulatory hormone, with the ability to reduce cellular proliferation in psoriasis. Ischaemia-modified albumin (IMA) is a marker of oxidative stress. This study examined 25-hydroxy vitamin D, IMA and high-sensitivity C-reactive protein (hs-CRP) levels in patients with psoriasis, in comparison with healthy controls and their possible association with disease severity...
2015: British Journal of Biomedical Science
Xuesong Li, Zhihua Huang, Hong Wang
OBJECTIVE: To study the clinical characteristics and early diagnosis of children with 3β-hydroxy-Δ(5)-C27-steroid dehydrogenase (3β-HSD) deficiency. METHOD: Data related to clinical characteristics, serum biochemistry, liver pathology, gene mutations and treatment of two children with 3β-HSD deficiency were analyzed and relevant literature was reviewed. Fifty-three cases of 3β-HSD deficiency were reported since 1993 in the world. RESULT: (1) Both patients showed neonatal cholestasis, blood biochemical examination of patient one showed alanine aminotransferase 292 U/L, aspartate aminotransferase 458 U/L, serum bile acids 1...
May 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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