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vitamin c serum

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https://www.readbyqxmd.com/read/29788779/elevated-serum-lipid-peroxidation-and-reduced-vitamin-c-and-trace-element-concentrations-are-correlated-with-epilepsy
#1
Abhijit Das, Md Shahid Sarwar, Md Shohel Hossain, Palash Karmakar, Mohammad Safiqul Islam, Mohammad Enayet Hussain, Sujan Banik
BACKGROUND: Epilepsy is one of the chronic and heterogeneous epidemic neurological disorders leading to substantial mortality. The aim of the present study was to investigate the serum levels of malondialdehyde (MDA), vitamin C, and trace elements namely zinc (Zn), copper (Cu), and manganese (Mn) in epileptic patients of Bangladesh and to establish if there are any pathophysiological correlations. METHODS: This was a case-control study with 40 generalized epileptic patients and 40 healthy subjects as controls...
May 1, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29782992/single-ultra-high-dose-cholecalciferol-to-prevent-vitamin-d-deficiency-in-pediatric-hematopoietic-stem-cell-transplantation
#2
Gregory Wallace, Sonata Jodele, Kasiani C Myers, Christopher E Dandoy, Javier El-Bietar, Adam Nelson, Ashley Teusink-Cross, Pooja Khandelwal, Cynthia Taggart, Catherine M Gordon, Stella M Davies, Jonathan C Howell
BACKGROUND: Vitamin D (vitD) deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior transplant survival at 100 days after transplantation. Achieving and maintaining therapeutic vitD levels in HSCT recipients is extremely challenging in the first 3-6 months after transplant due to poor compliance in the setting of mucositis, and concomitant use of critical transplant drugs that interfere with vitD absorption. We sought to evaluate the safety and efficacy of a single, ultra-high dose of vitD given prior to childhood HSCT to maintain levels in a therapeutic range during the peri-transplantation period...
May 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29779702/vitamin-d-is-not-useful-as-a-biomarker-for-disease-activity-in-rheumatoid-arthritis
#3
Paola de la Torre Lossa, Mario Moreno Álvarez, María Del Carmen González Guzmán, Rafael López Martínez, Carlos Ríos Acosta
OBJECTIVE: To determine whether there is an association between serum vitamin D levels and the Disease Activity Index in patients with rheumatoid arthritis (RA). METHODOLOGY: An analytical, retrospective, cross-sectional study was performed at the Hospital Luis Vernaza and Center for Rheumatology and Rehabilitation. We included 18 to 75-year-old patients with a diagnosis of RA according to the 2010 classification criteria, and with a 25-hydroxyvitamin D (25 [OH] D) test within the last 3 months...
May 17, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29777621/serum-high-density-lipoprotein-cholesterol-is-a-protective-predictor-of-executive-function-in-older-patients-with-diabetes-mellitus
#4
Yue Sun, Jenny Lee, Ronald C Ma, Timothy Kwok
INTRODUCTION: Older people with diabetes mellitus (DM) are at high risk for cognitive impairment or dementia. The clinical predictors for cognitive decline in older people with DM were elucidated. METHODS: This was a secondary analysis of a vitamin B12 intervention trial in older people with DM. 271 non-demented subjects were followed up at nine months interval for 27 months. We explored the association between baseline clinical features with changes in cognitive measures (clinical dementia rating scale, neuropsychological test battery including executive function z scores, psychomotor speed z scores and memory z scores)...
May 19, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29764903/vitamin-d-supplementation-does-not-improve-cvd-risk-factors-in-vitamin-d-insufficient-subjects
#5
Julia Magdalena Kubiak, Per Medbøe Thorsby, Elena Kamycheva, Rolf Jorde
OBJECTIVE: Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects. DESIGN: Double-blinded randomized controlled trial. METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of blood pressure, lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B), and glucose metabolism parameters (blood glucose, HbA1c, sRAGE, insulin, C-peptide, and HOMA-IR)...
May 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29761544/effect-of-dietary-counselling-with-prosthetic-restoration-on-fruit-and-vegetable-intake-in-partially-dentate-patients-a-prospective-study
#6
Gen Nabeshima, Kenji Fueki, Yuka Inamochi, Noriyuki Wakabayashi
The aim of this study was to investigate the effects of a counselling-based dietary intervention on nutritional status in partially dentate patients receiving removable partial dentures (RPDs). Thirty-eight patients [mean age (standard deviation): 73.2 (7.7) years] who were scheduled to receive RPDs at a dental hospital and were currently eating < 350 g of vegetables per day were included in the study. A dentist provided basic dietary counselling aimed at increasing dietary fruit and vegetable intake and improving dietary habits...
May 14, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29757287/combinational-treatment-of-trichostatin-a-and-vitamin-c-improves-the-efficiency-of-cloning-mice-by-somatic-cell-nuclear-transfer
#7
Rika Azuma, Kei Miyamoto, Mami Oikawa, Masayasu Yamada, Masayuki Anzai
Somatic cell nuclear transfer (SCNT) provides a unique opportunity to directly produce a cloned animal from a donor cell, and it requires the use of skillful techniques. Additionally, the efficiencies of cloning have remained low since the successful production of cloned animals, especially mice. There have been many attempts to improve the cloning efficiency, and trichostatin A (TSA), a histone deacetylase inhibitor, has been widely used to enhance the efficiency of cloning. Here, we report a dramatically improved cloning method in mice...
April 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29754319/responses-of-rainbow-trout-intestinal-epithelial-cells-to-different-kinds-of-nutritional-deprivation
#8
Patrick G Pumputis, Vivian R Dayeh, Lucy E J Lee, Phuc H Pham, Zhenzhen Liu, Senthuri Viththiyapaskaran, Niels C Bols
In order to develop an in vitro system to study the cell biology of starvation in the fish intestine, rainbow trout intestinal epithelial cells were subjected to three kinds of nutrient deprivation and evaluated for 7 days. The RTgutGC cell line was grown into monolayers in Leibovitz's basal medium supplemented with fetal bovine serum (L15/FBS) and then subjected to deprivation of serum (L15); of serum, amino acids, and vitamin (L15/ex); and of all nutrients (L15/salts). After 7 days of nutrient deprivation, the cells remained attached to the plastic surface as monolayers but changes were seen in shape, with the cells becoming more polygonal, actin and α-tubulin cytoskeleton organization, and in tight junction protein-1 (ZO-1) localization...
May 12, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29748907/effect-of-combined-vitamin-d-receptor-activator-and-lanthanum-carbonate-on-serum-fibroblast-growth-factor-23-level-in-predialysis-patients-cvd-laf-study-design-and-method
#9
Eri Ito, Daijo Inaguma, Shigehisa Koide, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa, Yukio Yuzawa
BACKGROUND: Whether vitamin D receptor activator (VDRA) use is beneficial in chronic kidney disease (CKD) is unclear, because it is possible that VDRA increases serum fibroblast growth factor 23 (FGF23) levels. We will conduct a randomized controlled trial in predialysis patients to determine the effect of VDRA alone or in combination with lanthanum carbonate (LC) on serum FGF23 levels. METHODS: This is a single-center, open-label, randomized controlled trial. Enrollment will commence February 1, 2018, using the following inclusion criteria: (1) age ≥ 20 years, (2) CKD with an estimated glomerular filtration rate of 10-45 mL/min/1...
May 10, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29745686/does-incipient-dementia-explain-normal-cognitive-decline-determinants-lothian-birth-cohort-1921
#10
Ruth A Sibbett, Tom C Russ, Alison Pattie, John M Starr, Ian J Deary
The presence of an apolipoprotein E (APOE) ε4 allele, lower physical fitness, smoking, and lower serum vitamin B-12 have been reported as contributing to poorer cognitive function in LBC1921 at age 79, after adjusting for childhood intelligence. Because incident dementia was not previously ascertained within LBC1921, it is possible that preclinical or unrecognized cases at age 79 influenced findings. Dementia cases arising over approximately 16 years of follow-up were determined by a consensus using evidence from electronic medical records, death certificates, and clinical reviews...
May 10, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29743793/bone-health-and-impact-of-tenofovir-treatment-in-men-with-hepatitis-b-related-chronic-liver-disease
#11
Kattiparambil G Sajith, Nitin Kapoor, Sahana Shetty, Ashish Goel, Uday Zachariah, Chundamannil E Eapen, Thomas V Paul
Background: Chronic Liver Disease (CLD) has been shown to have an adverse impact on bone health. Hepatitis-B related CLD and its treatment with tenofovir may have additional effects on skeleton. Objective: To study the impact of HBV related CLD and its treatment with Tenofovir on bone health in Indian subjects. Methods: This cross sectional study included men (18-60 years) and comprised of three groups: Group-1 was treatment naïve HBV related CLD ( n  = 79), Group-2 those with HBV related CLD on tenofovir for at least 1 year ( n  = 136), Group-3 age, sex and Body Mass Index (BMI) matched healthy controls ( n  = 58)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743767/pressure-ulcer-and-nutrition
#12
REVIEW
Seied Hadi Saghaleini, Kasra Dehghan, Kamran Shadvar, Sarvin Sanaie, Ata Mahmoodpoor, Zohreh Ostadi
Pressure ulcers can diminish global life quality, contribute to rapid mortality in some patients and pose a significant cost to health-care organizations. Accordingly, their prevention and management are highly important. Nutritional deprivation and insufficient dietary intake are the key risk factors for the development of pressure ulcers and impaired wound healing. Unplanned weight loss is a major risk factor for malnutrition and pressure ulcer development. Suboptimal nutrition interferes with the function of the immune system, collagen synthesis, and tensile strength...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29741927/transcellular-transport-of-cobalamin-in-aortic-endothelial-cells
#13
Luciana Hannibal, Keerthana Bolisetty, Armend Axhemi, Patricia M DiBello, Edward V Quadros, Sergey Fedosov, Donald W Jacobsen
Cobalamin [Cbl (or B12 )] deficiency causes megaloblastic anemia and a variety of neuropathies. However, homeostatic mechanisms of cyanocobalamin (CNCbl) and other Cbls by vascular endothelial cells are poorly understood. Herein, we describe our investigation into whether cultured bovine aortic endothelial cells (BAECs) perform transcytosis of B12 , namely, the complex formed between serum transcobalamin and B12 , designated as holo-transcobalamin (holo-TC). We show that cultured BAECs endocytose [57 Co]-CNCbl-TC (source material) via the CD320 receptor...
May 9, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29739041/1%C3%AE-25-oh-2-vitamin-d3-inhibits-c2c12-cell-differentiation-by-activating-c-src-and-erk1-2
#14
Zhonghua Wang, Aijun Jiang, Jingwei Mei, Xinyan Zhang
BACKGROUND: The steroid hormone 1α,25(OH)2-vitamin D3 (1,25-D3) induced some biological responses through activation of MAPK cascades in various cell types. It seems that 1,25-D3 plays different roles at different stages of proliferating, differentiating, and differentiated C2C12 cells. We wanted to detect the effect of 1,25-D3 on myogenic differentiation and the role of ERK1/2 in differentiating stage induced by 2% horse serum with 1,25-D3. METHODS: In this study, cells were induced to differentiate with 2% horse serum until the 7th day (with addition of 1,25-D3 every two days)...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737412/factors-associated-with-inadequate-responses-to-risedronate-in-japanese-patients-with-osteoporosis
#15
Ryo Okazaki, Ryoichi Muraoka, Masayuki Maehara, Daisuke Inoue
Factors associated with an inadequate response (IR) to bisphosphonates have been reported in many countries, but not in Japan, where the approved dose is half the global dose. We analyzed factors associated with IR to risedronate in Japanese patients with osteoporosis. This was a post hoc analysis of 1261 Japanese osteoporosis patients who received risedronate for 1 year in phase III trials. IR was defined as more than one new vertebral fracture (VF) and/or negative change in lumbar spine bone mineral density (BMD) at 1 year...
May 8, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29736388/aqueous-extract-of-carica-papaya-linn-roots-potentially-attenuates-arsenic-induced-biochemical-and-genotoxic-effects-in-wistar-rats
#16
Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Olayinka Awoyinka, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Olukemi Adetutu Osukoya, Israel Idowu Olayide, Adejoke Ibitayo
In Africa, the fruit, leaf, seed and roots of Carica papaya Linn. are generally used to treat a variety of diseases such as malaria, cancer, and cardiovascular diseases. In this study, we evaluated the protective potentials of aqueous extract of C. papaya roots on arsenic-induced biochemical and genotoxic effects in Wistar rats. Rats were induced intraperitoneal with sodium arsenate (dissolved in distilled water at 3 mg/kg body weight) for 21 days and the animals were administered simultaneously with 200 mg/kg body weight vitamin C, 100 and 150 mg/kg body weight of the C...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29734698/disparate-habitual-physical-activity-and-dietary-intake-profiles-of-elderly-men-with-low-and-elevated-systemic-inflammation
#17
Dimitrios Draganidis, Athanasios Z Jamurtas, Theodoros Stampoulis, Vasiliki C Laschou, Chariklia K Deli, Kalliopi Georgakouli, Konstantinos Papanikolaou, Athanasios Chatzinikolaou, Maria Michalopoulou, Constantinos Papadopoulos, Panagiotis Tsimeas, Niki Chondrogianni, Yiannis Koutedakis, Leonidas G Karagounis, Ioannis G Fatouros
The development of chronic, low-grade systemic inflammation in the elderly (inflammaging) has been associated with increased incidence of chronic diseases, geriatric syndromes, and functional impairments. The aim of this study was to examine differences in habitual physical activity (PA), dietary intake patterns, and musculoskeletal performance among community-dwelling elderly men with low and elevated systemic inflammation. Nonsarcopenic older men free of chronic diseases were grouped as &lsquo;low&rsquo; (LSI: n = 17; 68...
May 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29732934/no-association-between-the-vitamin-d-pathway-gene-polymorphisms-and-bone-biomarkers-response-to-calcium-and-low-dose-calcitriol-supplementation-in-postmenopausal-chinese-women-a-one-year-prospective-study
#18
Jiemei Gu, Chun Wang, Hao Zhang, Hue Yue, Weiwei Hu, Jinwei He, Wenzhen Fu, Zhenlin Zhang
INTRODUCTION: The aim of the study was to explore the association between the Vitamin D pathway gene variations and the bone biomarkers response to calcium and low dose calcitriol supplementation in postmenopausal Chinese women. METHODS: A total of 110 healthy postmenopausal Chinese women (61.51±6.93 years) were enrolled. The participants were supplemented with calcium (600 mg/d) and calcitriol (0.25 μg/d), for 1 year. Four biomarkers, serum levels of beta C-terminal cross-linked telopeptides of type I collagen (β-CTX), amino-terminal propeptide of type I collagen (P1NP), parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] were measured at baseline and 12-month follow-up...
May 7, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29726119/inverse-association-of-vitamin-d-3-levels-with-lung-cancer-mediated-by-genetic-variation
#19
Majda Haznadar, Kristopher W Krausz, Ezra Margono, Christopher M Diehl, Elise D Bowman, Soumen Kanti Manna, Ana I Robles, Bríd M Ryan, Frank J Gonzalez, Curtis C Harris
Vitamin D is an essential micronutrient required for normal physiological function and recognized for its role regulating calcium metabolism. Recent work is beginning to emerge demonstrating a role for vitamin D in chronic illnesses, such as cancer. Circulating serum levels of 25(OH)D2/3 were quantitatively measured using sensitive ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) in 406 lung cancer cases and 437 population controls, while 1,25(OH)2 D2/3 levels were measured in a subset of 90 cases and 104 controls using the same method, from the NCI-MD case-control cohort...
May 3, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29725544/stability-of-folate-and-vitamin-b-12-in-human-serum-after-long-term-storage-a-follow-up-after-13-years
#20
Eugène H J M Jansen, Piet K Beekhof
In epidemiological and nutrition research, it is very important to evaluate the stability of biomarkers as function of both storage time and temperature. In this study, the stability of folate and vitamin B12 in human serum samples has been tested after long-term storage at -80°C up to 13 years. Serum samples of 16 individuals were used in this study. The concentration of folate and vitamin B12 has been determined at t =0 and at 1, 8, and 13 years after storage at -80°C. The folate concentrations in serum samples remained stable at -80°C...
2018: Journal of Nutrition and Metabolism
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