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https://www.readbyqxmd.com/read/28531643/lipid-based-nutrient-supplements-containing-vitamins-and-minerals-attenuate-renal-electrolyte-loss-in-hiv-aids-patients-starting-antiretroviral-therapy-a-randomized-controlled-trial-in-zambia
#1
D Munkombwe, T L Muungo, C Michelo, P Kelly, S Chirwa, S Filteau
BACKGROUND & AIMS: Advanced HIV infection combined with undernutrition and antiretroviral therapy (ART) places HIV/AIDS patients at high risk of electrolyte abnormalities and increased morbidity and mortality. Here, in a sub-study of a large published randomized trial, we evaluated if nutritional supplements will help curtail renal electrolyte loss in HIV/AIDS patients starting ART. METHODS: 130 malnourished HIV-positive patients referred for ART received lipid-based nutrient supplements alone (LNS, n = 63) or together with vitamins and minerals (LNS-VM, n = 67)...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531130/comparative-safety-and-efficacy-profile-of-a-novel-oil-in-water-vaccine-adjuvant-comprising-vitamins-a-and-e-and-a-catechin-in-protective-anti-influenza-immunity
#2
Sapna Patel, Yasser Faraj, Debra K Duso, William W Reiley, Erik A Karlsson, Stacey Schultz-Cherry, Michael Vajdy
Non-replicating vaccines, such as those based on recombinant proteins, require adjuvants and delivery systems, which have thus far depended on mimicking pathogen danger signals and strong pro-inflammatory responses. In search of a safer and more efficacious alternative, we tested whether vaccinations with influenza recombinant hemagglutinin (HA) mixed with a novel vegetable oil in water emulsion adjuvant (Natural Immune-enhancing Delivery System, NIDS), based on the immune-enhancing synergy of vitamins A and E and a catechin, could protect against intra-nasal challenge with live influenza virus...
May 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28526622/9-cis-retinoic-acid-modulates-the-type-i-allergic-immune-response
#3
Guido Heine, Tim Hollstein, Sandra Treptow, Andreas Radbruch, Margitta Worm
BACKGROUND: Vitamin A is a potent regulator of adaptive immunity. The impact of the endogenous metabolite 9-cis retinoic acid (9cRA) on allergic sensitization is unknown. OBJECTIVE: To investigate whether and to what extent 9cRA modulates the humoral immune response. METHODS: BALB/c mice were sensitized and challenged with ovalbumin (OVA). 9cRA was applied repeatedly together with the antigen. Immunoglobulin production and cellular analysis were performed by ELISA, ELISPOTs and flow-cytometry...
May 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28526388/serum-vitamin-d-and-change-in-lipid-levels-over-5%C3%A2-y-the-atherosclerosis-risk-in-communities-study
#4
Kamil F Faridi, Di Zhao, Seth S Martin, Joshua R Lupton, Steven R Jones, Eliseo Guallar, Christie M Ballantyne, Pamela L Lutsey, Erin D Michos
OBJECTIVES: Deficiency of 25-hydroxyvitamin D (25[OH]D) is associated with increased risk for cardiovascular disease, perhaps mediated through dyslipidemia. Deficient 25(OH)D is cross-sectionally associated with dyslipidemia, but little is known about longitudinal lipid changes. The aim of this study was to determine the relationship of 25(OH)D deficiency to longitudinal lipid changes and risk for incident dyslipidemia. METHODS: This was a longitudinal community-based study of 13 039 participants from the ARIC (Atherosclerosis Risk in Communities) study who had 25(OH)D and lipids measured at baseline (1990-1992) and lipids remeasured in 1993 to 1994 and 1996 to 1998...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526382/quality-of-diet-and-level-of-physical-performance-related-to-inflammatory-markers-in-community-dwelling-frail-elderly-people
#5
Do-Yeon Kim, Chang-O Kim, Hyunjung Lim
OBJECTIVE: The aim of this study was to assess whether diet quality and functional status were associated with serum levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in frail, elderly, community-dwelling individuals. METHODS: Seventy-eight frail, elderly individuals (age ≥65 y, usual gait speed <0.6 m/s and Mini Nutritional Assessment <24) participated in this cross-sectional study from the National Home Healthcare Services in Gangbuk-gu, Seoul, South Korea...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28511498/antioxidant-oxidant-index-as-a-biomarker-in-oral-potentially-malignant-disorders-and-oral-squamous-cell-carcinoma-a-biochemical-study
#6
Saurabh Juneja, Ajit Singh Rathore, Kanika Sharma, Devicharan Shetty, Anshi Jain
INTRODUCTION: Oxidative stress has been implicated in tumourigenesis by affecting the actions of various protein kinases and transcription factors, and resulting in damage to DNA structure by the deamination of nucleotides and the generation of free radicals. Derangements in the antioxidant defence mechanism have been considered in the pathogenesis of oral cancer. AIM: To evaluate and compare the serum levels of nitric oxide and vitamin C in cases of Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCC) and healthy controls...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509078/the-effects-of-vitamin-d-supplementation-on-proatherogenic-inflammatory-markers-and-carotid-intima-media-thickness-in-subjects-with-metabolic-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#7
Shabnam Salekzamani, Abolhassan Shakeri Bavil, Hossein Mehralizadeh, Mohammad Asghari Jafarabadi, Aymaral Ghezel, Bahram Pourghassem Gargari
PURPOSE: Metabolic syndrome may predispose to cardiovascular diseases. Since, in recent studies, vitamin D is advocated for cardioprotective roles, this study was designed to investigate the effects of vitamin D supplementation on proatherogenic inflammatory markers and common carotid intima media thickness in subjects with metabolic syndrome. METHODS: This randomized double blind clinical trial was conducted in Tabriz, Iran. Eligible subjects (n = 80) with metabolic syndrome were recruited thorough advertisement and randomized to receive either vitamin D (50,000 IU/week) or matching placebo for 16 weeks...
May 16, 2017: Endocrine
https://www.readbyqxmd.com/read/28503504/antioxidant-status-and-risk-of-gestational-diabetes-mellitus-a-case-control-study
#8
Vida Mohammad Parast, Zamzam Paknahad
Gestational diabetes mellitus (GDM) is described as glucose intolerance diagnosed during pregnancy. Increased oxidative stress has implicated in diabetic problems. The aim of the current study was to compare antioxidant capacity and antioxidant nutrient intake between women with GDM (n = 40) and healthy pregnant women (n = 40). Demographic and obstetrics data were completed using interview technique and dietary intakes by using a semi-quantitative food frequency questionnaire (FFQ) with 168 items. The total antioxidant capacity (TAC) of serum was assessed by double-antibody sandwich enzyme-linked immune-sorbent assay (ELISA) method...
April 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28501775/vitamin-d-correlation-with-biochemical-and-body-composition-changes-in-a-southern-brazilian-population-and-induction-of-cytotoxicity-in-mesenchymal-stem-cells-derived-from-human-adipose-tissue
#9
João Renato Pesarini, Rodrigo Juliano Oliveira, Lucas Roberto Pessatto, Andréia Conceição Milan Brochado Antoniolli-Silva, Ingrid Felicidade, Nance Beyer Nardi, Melissa Camassola, Mário Sérgio Mantovani, Lúcia Regina Ribeiro
Studies have shown that metabolic disorders, serum inflammatory markers and weight gain (obesity) are correlated with vitamin D deficiency. Therefore, the present study correlated the serum calcidiol (s25(OH)D3) levels in a sample of individuals from southern Brazil with variables related to metabolic disorders, obesity and lifestyle habits and assessed the cytotoxic effect of calcitriol on adipose tissue-derived mesenchymal stem cells (ADSCs). The results showed a 79.23% prevalence of hypovitaminosis D in the study population and a correlation (p<0...
May 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28498788/nutritional-status-energy-expenditure-and-protein-oxidative-stress-after-kidney-transplantation
#10
Larissa Vieira Marino, Elen Almeida Romão, Paula Garcia Chiarello
OBJECTIVES: To evaluate the association between nutritional status, resting energy expenditure (REE), and protein oxidative stress in patients after kidney transplantation (KT). METHODOLOGY: The study evaluated 35 patients transplanted at the time of hospital discharge and 3 months after regarding: body composition, REE (by indirect calorimetry), and injury factor (IF); serum urea, creatinine, glucose, albumin, total protein, advanced oxidation protein products (AOPP), vitamin C...
May 12, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28493902/circulating-levels-of-sclerostin-but-not-dkk1-associate-with-laboratory-parameters-of-ckd-mbd
#11
Geert J Behets, Liesbeth Viaene, Björn Meijers, Frank Blocki, Vincent M Brandenburg, Anja Verhulst, Patrick C D'Haese, Pieter Evenepoel
INTRODUCTION: Mounting evidence indicates that a disturbed Wnt-β-catenin signaling may be involved in the pathogenesis of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD). Data on the impact of CKD on circulating levels of the Wnt antagonists sclerostin and Dickkopf related protein 1 (DKK1) and the relationship with laboratory parameters of CKD-MBD are incomplete. METHODS: We analyzed serum sclerostin and DKK1 in 308 patients across the stages of chronic kidney disease (kDOQI stage 1-2 n = 41; CKD stage 3 n = 54; CKD stage 4-5 n = 54; hemodialysis n = 100; peritoneal dialysis n = 59) as well as in 49 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28492801/orthotopic-tumorgrafts-in-nude-mice-as-a-model-to-evaluate-calcitriol-effects-in-breast-cancer
#12
V C N Fonseca-Filho, M L H Katayama, E C Lyra, D A Maria, R A Basso, S Nonogaki, J M Guerra, S Maistro, J C G S Góes, M A A K Folgueira
Objectives: To establish a tumorgraft model, from freshly collected breast cancer samples, which were directly implanted in nude mice, to study calcitriol effects. Methods: Breast cancer samples collected from 12 patients were orthotopically implanted into nude mice. Animals were treated with weekly intratumoral injections of calcitriol 3 μg/Kg, which was previously shown to induce peak serum calcitriol levels in the predicted therapeutic range. Results: Success engraftment rate was 25%...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28488734/body-size-and-the-risk-of-primary-hyperparathyroidism-in-women-a-cohort-study
#13
Anand Vaidya, Gary C Curhan, Julie M Paik, Molin Wang, Eric N Taylor
Greater body weight and fat mass have been associated with higher serum parathyroid hormone levels and a higher prevalence of primary hyperparathyroidism (P-HPTH) in women. However, prospective studies to evaluate whether greater body size associates with a higher incidence of developing P-HPTH have not been reported. We investigated whether greater body size was independently associated with a higher risk for developing P-HPTH in women. We conducted a prospective cohort study of 85,013 female participants in the Nurses' Health Study I followed for up to 26 years...
May 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28486474/vitamin-d-levels-and-susceptibility-to-asthma-elevated-immunoglobulin-e-levels-and-atopic-dermatitis-a-mendelian-randomization-study
#14
Despoina Manousaki, Lavinia Paternoster, Marie Standl, Miriam F Moffatt, Martin Farrall, Emmanuelle Bouzigon, David P Strachan, Florence Demenais, Mark Lathrop, William O C M Cookson, J Brent Richards
BACKGROUND: Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological associations, if true, would have public health importance, since vitamin D insufficiency is common and correctable. METHODS AND FINDINGS: We aimed to test whether genetically lowered vitamin D levels were associated with risk of asthma, atopic dermatitis, or elevated serum IgE levels, using Mendelian randomization (MR) methodology to control bias owing to confounding and reverse causation...
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28486434/neonatal-and-maternal-25-oh-vitamin-d-serum-levels-in-neonates-with-early-onset-sepsis
#15
Taha Soliman Gamal, Abd-Allah Sayed Madiha, Mostafa Kamel Hanan, Mohamed El-Mazary Abdel-Azeem, Gamil S Marian
Vitamin D is a fat-soluble vitamin that is important for calcium metabolism and plays an important role in the immune functions. The aim of this study was to measure neonatal and maternal 25-OH vitamin D serum levels in neonates with early onset sepsis. The study included fifty neonates with early onset sepsis (25 full-term and 25 preterm infants) and thirty age and sex matched healthy neonates as controls. After history taking and clinical examination, complete blood count, C-reactive protein and 25-OH vitamin D serum levels (neonatal and maternal) were measured for all neonates...
May 9, 2017: Children
https://www.readbyqxmd.com/read/28483427/association-between-muscle-function-and-body-composition-vitamin-d-status-and-blood-glucose-in-postmenopausal-women-with-type-2-diabetes
#16
Claudio M Bentes, Pablo B Costa, Monique Resende, Humberto L Miranda, Carolina M V Silva, Claudia C Netto, Lizanka P F Marinheiro
AIMS: The aim of this study was to examine the association between muscle function, and body composition, vitamin D status, and blood glucose in post-menopausal women with type 2 diabetes (T2D). METHODS: Forty post-menopausal women (62.48±7.67years; 154.6±5.11cm; 73.93±15.43kg; 31.13±5.82 BMI kg/m(2)) with a diagnosis of T2D participated in this cross-sectional study. The patients performed fasting blood sample exams, anthropometrics assessments, body composition, and clinical exams...
April 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28483406/rates-of-inappropriate-laboratory-test-utilization-in-ontario
#17
Nadine Chami, Janet Simons, Arthur Sweetman, Andrew C Don Wauchope
BACKGROUND: Medical laboratory tests ordered redundantly represent one of the targets for reducing diagnostic testing without negatively, and possibly positively, affecting patient care. We study a clearly defined category of excessive laboratory utilization for nine analytes where inappropriate diagnostic testing is defined in terms of the time interval between tests; that is, ordering a test too soon following the previous order of the same test. METHODS: Population data from the near universal public Ontario Health Insurance Plan for the years 2006-2010 are employed where the tests are fulfilled by community medical laboratories...
May 5, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28482093/can-nutrition-or-inflammation-moderate-the-age-cognition-association-among-older-adults
#18
Elizabeth P Handing, Brent J Small, Ross Andel, Cathy L McEvoy, Nagi Kumar
Objectives: Previous research has shown that nutrition can influence cognitive abilities in older adults. We examined whether nutritional factors or inflammatory biomarkers moderate the age-cognition association. Method: Analyses included 1,308 participants (age ≥60) from the National Health and Nutrition Examination Survey III. Macronutrients (% of calories from fat, protein, and carbohydrates), micronutrients/amino acids (blood serum values: Vitamins B12, C, D, E, folate, iron, homocysteine, and β-carotene), and inflammatory biomarkers (serum C-reactive protein, plasma fibrinogen, and serum ferritin) were examined as moderators with cognition...
May 6, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28481882/vitamin-d-supplementation-and-growth-in-urban-mongol-school-children-results-from-two-randomized-clinical-trials
#19
Davaasambuu Ganmaa, Jennifer J Stuart, Nyamjav Sumberzul, Boldbaatar Ninjin, Edward Giovannucci, Ken Kleinman, Michael F Holick, Walter C Willett, Lindsay A Frazier, Janet W Rich-Edwards
BACKGROUND: Symptomatic vitamin D deficiency is associated with slowed growth in children. It is unknown whether vitamin D repletion in children with asymptomatic serum vitamin D deficiency can restore normal growth. OBJECTIVE: We tested the impact of vitamin D-supplementation on serum concentrations of 25-hydroxyvitamin D [25(OH)D] and short-term growth in Mongol children, with very low serum vitamin D levels in winter. DESIGN: We conducted two randomized, double-blind, placebo-controlled trials in urban school age children without clinical signs of rickets...
2017: PloS One
https://www.readbyqxmd.com/read/28477055/link-between-community-acquired-pneumonia-and-vitamin%C3%A2-d-levels-in-older-patients
#20
Dongxi Lu, Jiandong Zhang, Chunming Ma, Yuanyuan Yue, Zhehua Zou, Changying Yu, Fuzai Yin
PURPOSE: To investigate the correlation between the level of 25-hydroxyvitamin D [25-(OH)D] and community-acquired pneumonia (CAP) in elderly patients. METHODS: A total of 163 older patients were chosen from those hospitalized between October 2011 and October 2012. Patients were divided into pneumonia and non-pneumonia groups, and the concentrations of 25-(OH)D (nmol/L) in serum were measured. Clinical data were then compared between the two groups and pneumonia-related risk factors were analyzed using logistic regression...
May 5, 2017: Zeitschrift Für Gerontologie und Geriatrie
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