keyword
MENU ▼
Read by QxMD icon Read
search

k2 vitamin

keyword
https://www.readbyqxmd.com/read/29773167/optimal-dosage-and-early-intervention-of-l-ascorbic-acid-inhibiting-k-2-cr-2-o-7-induced-renal-tubular-cell-damage
#1
Tzeng-Jih Lin, Yeou-Lih Huang, Jung-San Chang, Kuan-Ting Liu, Meng-Chi Yen, Fen-Wei Chen, Yueh-Lun Shih, Jo-Chi Jao, Po-Chi Huang, I-Jeng Yeh
Chromium poisoning can cause renal failure and death. Chromium intoxication may be managed using L-ascorbic acid (vitamin C) therapy. However, the evidence supporting the effectiveness of this treatment is insufficient, and the mechanism of action has not been clarified in renal cells. In this study, our results showed that the optimal regimen of L-ascorbic acid therapy in human epithelial renal proximal tubule cells, HK-2 cells, was 30 μg/mL. Supplementation of L-ascorbic acid with 30 μg/mL and within 8 h of chromium intoxication (K2 Cr2 O7, Cr6+ ) was effective to inhibit renal tubular cell damage by blocking generation of free radicals, cell apoptosis, and autophagy...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29749440/vitamin-k%C3%A2-dependent-proteins-involved-in-bone-and-cardiovascular-health-review
#2
Lianpu Wen, Jiepeng Chen, Lili Duan, Shuzhuang Li
In postmenopausal women and elderly men, bone density decreases with age and vascular calcification is aggravated. This condition is closely associated with vitamin K2 deficiency. A total of 17 different vitamin K‑dependent proteins have been identified to date. Vitamin K‑dependent proteins are located within the bone, heart and blood vessels. For instance, carboxylated osteocalcin is beneficial for bone and aids the deposition of calcium into the bone matrix. Carboxylated matrix Gla protein effectively protects blood vessels and may prevent calcification within the vascular wall...
April 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749330/bone-mineral-density-and-vitamin-k-status-in-children-with-celiac-disease-is-there-a-relation
#3
Burcu Volkan, Ali Fettah, Ali İşlek, Soner Sertan Kara, Nezahat Kurt, Atilla Çayır
BACKGROUND/AIMS: To investigate bone mineral density (BMD) in children with celiac disease (CD) and to evaluate the association between vitamin K levels and osteoporosis. MATERIALS AND METHODS: Children with CD and age- and sex-matched healthy control subjects were prospectively included in the study. BMD was measured, and serum anti-tissue transglutaminase IgA, ferritin, folate, vitamin B12, 25-hydroxy vitamin D and K2, calcium, phosphate, alkaline phosphatase, and parathormone were assayed in all subjects...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29705920/retraction-note-to-efficacy-of-menatetrenone-vitamin-k2-against-non-vertebral-and-hip-fractures-in-patients-with-neurological-diseases-meta-analysis-of-three-randomized-controlled-trials
#4
Jun Iwamoto, Hideo Matsumoto, Tsuyoshi Takeda
The Editor-in-Chief has retracted this article because two of the three studies [1, 2] included in the meta-analysis (cited as references 11 and 12) have been retracted due to fabrication of the data, which has rendered the results of this meta-analysis invalid.
May 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29697859/the-effects-of-vitamin-k1-and-vitamin-k2-on-the-proliferation-cytokine-production-and-regulatory-t-cell-frequency-in-peripheral-blood-mononuclear-cells-of-pediatric-atopic-dermatitis-patients
#5
Kehan Meng, Wencheng Xu, Taro Miura, Shunsuke Suzuki, Masako Chiyotanda, Sachiko Tanaka, Kentaro Sugiyama, Hisashi Kawashima, Toshihiko Hirano
We estimated the pharmacological efficacy of vitamin K1 (VK1 ) and VK2 on the mitogen-activated peripheral-blood mononuclear cells (PBMCs) of pediatric atopic dermatitis (AD) patients. VK2 suppressed the in vitro proliferation of T cell-mitogen-activated PBMCs of AD patients. In contrast, VK1 had little effect on the PBMC proliferation. The IL-2 production from the activated PBMCs of AD patients significantly increased (P<0.05), while the production significantly decreased by 100 μM VK2 (P<0.01). In addition, 100 μM VK2 reduced the percentage of CD4+ and CD4+CD25+cells in PBMCs...
April 26, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29663377/ubiad1-protects-against-oxygen-glucose-deprivation-reperfusion-induced-multiple-subcellular-organelles-injury-through-pi3k-akt-pathway-in-n2a-cells
#6
Yan Huang, Zhiping Hu
Cerebral ischemia/reperfusion-induced injury plays a significant role in the development of multi-subcellular organelles injury after ischemic stroke. UBIAD1 was discovered originally as a potential tumor suppressor protein. Recently, analysis of UBIAD1 has indicated it is a prenyltransferase enzyme for both non-mitochondrial CoQ10 and vitamin K2 production. Further, UBIAD1 has been localized to multiple subcellular organelles. Particularly, UBIAD1 plays an important role in the regulation of oxidative stress, apoptosis and cell proliferation, cholesterol and lipid metabolism, which was closely associated with the cerebral ischemic/reperfusion mechanism...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29617432/vitamin-k2-improves-proliferation-and-migration-of-bovine-skeletal-muscle-cells-in-vitro
#7
Sissel Beate Rønning, Mona Elisabeth Pedersen, Ragnhild Stenberg Berg, Bente Kirkhus, Rune Rødbotten
Skeletal muscle function is highly dependent on the ability to regenerate, however, during ageing or disease, the proliferative capacity is reduced, leading to loss of muscle function. We have previously demonstrated the presence of vitamin K2 in bovine skeletal muscles, but whether vitamin K has a role in muscle regulation and function is unknown. In this study, we used primary bovine skeletal muscle cells, cultured in monolayers in vitro, to assess a potential effect of vitamin K2 (MK-4) during myogenesis of muscle cells...
2018: PloS One
https://www.readbyqxmd.com/read/29617330/fermented-food-and-non-communicable-chronic-diseases-a-review
#8
REVIEW
Doreen Gille, Alexandra Schmid, Barbara Walther, Guy Vergères
Fermented foods represent a significant fraction of human diets. Although their impact on health is positively perceived, an objective evaluation is still missing. We have, therefore, reviewed meta-analyses of randomized controlled trials (RCT) investigating the relationship between fermented foods and non-transmissible chronic diseases. Overall, after summarizing 25 prospective studies on dairy products, the association of fermented dairy with cancer was found to be neutral, whereas it was weakly beneficial, though inconsistent, for specific aspects of cardio-metabolic health, in particular stroke and cheese intake...
April 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29561783/bicuspid-aortic-valve-stenosis-and-the-effect-of-vitamin-k2-on-calcification-using-18-f-sodium-fluoride-positron-emission-tomography-magnetic-resonance-the-basik2-rationale-and-trial-design
#9
Frederique E C M Peeters, Manouk J W van Mourik, Steven J R Meex, Jan Bucerius, Simon M Schalla, Suzanne C Gerretsen, Casper Mihl, Marc R Dweck, Leon J Schurgers, Joachim E Wildberger, Harry J G M Crijns, Bas L J H Kietselaer
BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) on imaging measurements of calcification in the bicuspid aortic valve (BAV) and calcific aortic valve stenosis (CAVS). BAV is associated with early development of CAVS. Pathophysiologic mechanisms are incompletely defined, and the only treatment available is valve replacement upon progression to severe symptomatic stenosis. Matrix Gla protein (MGP) inactivity is suggested to be involved in progression...
March 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29506628/the-determination-of-the-effect-of-some-1-3-4-thiadiazole-derivatives-on-biochemical-content-fatty-acids-sterols-lipophilic-vitamins-in-rat-liver
#10
Akif E Parlak, Yusuf Karagozoglu, Naci Ö Alayunt, Semra Turkoglu, Mustafa Karatepe, Metin Koparir
Thiadiazole derivatives and its metal compounds have antibacterial, antifungal, antitumoral, antiproliferative and antioxidant properties. In the study, the effects caused by thiadiazole ligand and its metal complexes upon the fatty acids and lipophilic vitamins in livers of rats were examined. The fatty acids in liver were specified by GC while the lipophilic vitamins were specified by HPLC. It was observed that the amounts of oleic acids (18:1, n-9) and monounsaturated fatty acids (MUFA) notably increased in the Mn complex group while the amounts of arachidonic acid (20:4, n-6) notably increased in the ligand group, compared to control group...
February 28, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29500722/vitamin-k2-in-multiple-sclerosis-patients
#11
Reza Lasemi, Michael Kundi, Nahid Beladi Moghadam, Hanns Moshammer, Johannes A Hainfellner
BACKGROUND: Vitamin K2 (VK2) belongs to the vitamin K family and comprises a number of subtypes differing in length of side chains consisting of isoprenoid groups (menaquinone-n, MK-n). It is essential for a number of physiological functions although the full spectrum of activity has not yet been elucidated. Due to its role in protection of mitochondrial damage, VK2 could be relevant in preventing disease progress in multiple sclerosis (MS). METHODS: We measured VK2 serum levels by the double antibody sandwich Enzyme-linked Immunosorbent Assay (ELISA) technique in MS patients and age and sex matched controls, both under vitamin D supplementation, and related it to disease characteristics and treatment...
March 2, 2018: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29484617/ascorbic-acid-protects-male-rat-brain-from-oral-potassium-dichromate-induced-oxdative-dna-damage-and-apoptotic-changes-the-expression-patterns-of-caspase-3-p-53-bax-and-bcl-2-genes
#12
Ehsan H Abu Zeid, Mohamed M A Hussein, Haytham Ali
Our study designed to study the potential of potassium dichromate (K2 Cr2 O7 ) oral exposure to induce damage in male rat brain and to compare the possible protective role of vitamin C (VC) either pre and/or concurrent supply against (K2 Cr2 O7 ) induced changes. Thirty male rats were divided into five groups. First control group received distilled water (C), second received 120 mg/kg b.wt (VC), third received 25 mg/kg b.wt K2 Cr2 O7 (Cr), fourth group received VC together with K2 Cr2 O7 by the same former doses (VC + Cr), and the fifth group received the same oral doses of VC 2 weeks prior to and along with K2 Cr2 O7 for 6 weeks (VC + Cr pro/co treated)...
May 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29480629/immunomodulatory-effect-of-vitamin-k2-implications-for-bone-health
#13
V D Myneni, E Mezey
OBJECTIVE: In women with postmenopausal osteoporosis, vitamin K2 appears to decrease the incidence of hip, vertebral, and non-vertebral fractures. Women with postmenopausal osteoporosis have more circulating activated T cells compared with healthy postmenopausal and premenopausal women, but the effects of vitamin K2 on T cells have not been studied. In this study, we have looked at T-cell suppression by vitamin K2. MATERIALS AND METHODS: Peripheral blood mononuclear cells (PBMCs) from three healthy donors were used...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29432837/vitamin-k2-a-menaquinone-present-in-dairy-products-targets-castration-resistant-prostate-cancer-cell-line-by-activating-apoptosis-signaling
#14
Subramanyam Dasari, Angela Lincy Prem Antony Samy, Andre Kajdacsy-Balla, Maarten C Bosland, Gnanasekar Munirathinam
The aim of this study was to evaluate the therapeutic effects of vitamin K2 (VK2) on castration-resistant prostate cancer (CRPC) and its anti-cancer mechanisms in a pre-clinical study using a VCaP cell line (ATCC® CRL-2876™) which was established from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. Our data showed that VK2 significantly inhibited CRPC VCaP cell proliferation in a dose-dependent manner at 48 h treatment in vitro. In addition, VK2 reduced the migration potential of VCaP cells and inhibited anchorage-independent growth of these cells...
February 9, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29429532/vitamin-k-2-alleviates-type-2-diabetes-in-rats-by-induction-of-osteocalcin-gene-expression
#15
Atef G Hussein, Randa H Mohamed, Sally M Shalaby, Dalia M Abd El Motteleb
OBJECTIVES: The biological mechanisms behind the association between vitamin K (Vit K) and glucose metabolism are uncertain. We aimed to analyze the expression of insulin 1 (Ins 1), insulin 2 (Ins 2) and cyclin D2, the expression of adiponectin and UCP-1 . In addition, we aimed to estimate the doses of Vit K2 able to affect various aspects of glucose and energy metabolism in type 2 diabetes. METHODS: Thirty adult male rats were allocated equally into five groups: control group, diabetes mellitus group, and groups 3, 4, and 5, which received Vit K2 at three daily dose levels (10, 15, and 30 mg/kg, respectively) for 8 wk...
March 2018: Nutrition
https://www.readbyqxmd.com/read/29407923/identification-of-menaquinones-vitamin-k2-homologues-as-novel-constituents-of-honey
#16
Linda Kim, Katrina Brudzynski
Our recent research indicated that honey active macromolecules form colloidal particles that scatter the light and produce elaborate UV spectral profile dominated by double absorption peaks at 240-250 nm. The absorption at 240-250 nm signified the stable honey conformation that supported antibacterial activity and hydrogen peroxide production. Our aim was to identify the bioactive constituent relevant to this absorption. The methodology included activity-guided fractionation of honey through size-exclusion chromatography, solid-phase extraction and UPLC-UV-MS...
May 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29395943/warfarin-accelerated-vascular-calcification-and-worsened-cardiac-dysfunction-in-remnant-kidney-mice
#17
Ming-Tsun Tsai, Ying-Ying Chen, Wei-Jeng Chang, Szu-Yuan Li
BACKGROUND: Vascular calcification is highly prevalent in end-stage renal disease (ESRD) and is a significant risk factor for future cardiovascular events and death. Warfarin use results in dysfunction of matrix Gla protein, an inhibitor of vascular calcification. However, the effect of warfarin on vascular calcification in patients with ESRD is still not well characterized. Thus we investigated whether arterial calcification can be accelerated by warfarin treatment both in vitro and in vivo using a mouse remnant kidney model...
April 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29380579/-synthesis-of-vitamin-k2-by-isopentenyl-transferase-nova-in-pichia-pastoris-gpn12
#18
Xihua Wu, Zhemin Li, Hui Liu, Peng Wang, Li Wang, Xue Fang, Xiaowen Sun, Wenfeng Ni, Qiang Yang, Zhiming Zheng, Genhai Zhao
The effect of methanol addition on the heterologous expression of isoprenyl transferase NovQ was studied in Pichia pastoris Gpn12, with menadione and isopentenol as precursors to catalyze vitamin K2 (MK-3) synthesis. The expression of NovQ increased by 36% when 2% methanol was added every 24 h. The influence of initial pH, temperature, methanol addition, precursors (menadione, isopentenol) addition, catalytic time and cetyltrimethyl-ammonium bromide (CTAB) addition were explored in the P. pastoris whole-cell catalytic synthesis process of MK-3 in shaking flask...
January 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29348256/flavonoids-dairy-foods-and-cardiovascular-and-metabolic-health-a-review-of-emerging-biologic-pathways
#19
REVIEW
Dariush Mozaffarian, Jason H Y Wu
A growing body of nutritional science highlights the complex mechanisms and pleiotropic pathways of cardiometabolic effects of different foods. Among these, some of the most exciting advances are occurring in the area of flavonoids, bioactive phytochemicals found in plant foods; and in the area of dairy, including milk, yogurt, and cheese. Many of the relevant ingredients and mechanistic pathways are now being clarified, shedding new light on both the ingredients and the pathways for how diet influences health and well-being...
January 19, 2018: Circulation Research
https://www.readbyqxmd.com/read/29333616/determination-of-vitamins-k-1-mk-4-and-mk-7-in-human-serum-of-postmenopausal-women-by-hplc-with-fluorescence-detection
#20
Eva Klapkova, Jana Cepova, Katerina Dunovska, Richard Prusa
BACKGROUND: New high-performance liquid chromatography (HPLC) method was developed for the determination of vitamin K1 and two forms of vitamin K2 (MK-4 and MK-7) in human serum, and the levels of vitamin K were determined in 350 samples of postmenopausal women. METHODS: Vitamin K was determined by HPLC with fluorescence detection after postcolumn zinc reduction. The detection was performed at 246 nm (excitation) and 430 nm (emission). The internal standard and 2 mL of ethanol were added to 500 μL of serum...
January 15, 2018: Journal of Clinical Laboratory Analysis
keyword
keyword
86321
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"