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https://www.readbyqxmd.com/read/28732258/areca-catechu-palm-tree-nut-chewing-and-seizures-an-observational-study
#1
Farrah J Mateen, Marco Carone, Lhab Tshering, Chencho Dorji, Ugyen Dema, Sara J Grundy, Dili Ram Pokhrel, Damber K Nirola
OBJECTIVE: The objective of this study was to report the impact of chronic abuse of Areca catechu nut wrapped in leaf (also known as doma, quid, paan), the fourth most commonly abused psychoactive substance worldwide, on the frequency of seizures among people with epilepsy. METHODS: People with clinically diagnosed epilepsy (>14years old) residing in the Kingdom of Bhutan were surveyed for self-reported Areca catechu use, demographic variables, epilepsy characteristics, and seizure frequency...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28731854/oral-submucous-fibrosis-in-a-school-going-indian-adolescent-boy
#2
Vishal Khandelwal, Hallaswamy V Kambalimath, Naveen B Reddy, Sushma Khandelwal, Vanaja Reddy, Nitu Gupta
A 14-year-old boy presented to our hospital with a chief complaint of difficulty in opening his mouth and a burning sensation on eating spicy food. The oral mucosa showed generalized diffused blanching and he was unable to protrude his tongue. For 6 years he had habitually chewed gutkha - a mixture of betel nut and tobacco for several minutes a day. This oral submucous fibrosis condition is very rare in young patients. The case highlights the link between oral submucous fibrosis and the regular use of areca nut (gutkha) products in a young boy...
July 21, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28729764/deciphering-the-role-of-micrornas-in-brd4-nut-fusion-gene-induced-nut-midline-carcinoma
#3
Ekta Pathak, Bhavya, Divya Mishra, Neelam Atri, Rajeev Mishra
NUT midline carcinoma (NMC) is a very aggressive and lethal type of squamous epithelial cell cancer caused due to fusion of BRD4 and NUT genes. The gene fusion results into a new fusion protein that promotes oncogenesis. The detailed molecular mechanisms underlying the NMC are still not clear and new findings are urgently required to complement the current efforts. Abnormal microRNAs (miRNA) expression promotes tumour formation by modulating the functional expression of critical genes other than the parent genes involved in tumour cell proliferation or survival...
2017: Bioinformation
https://www.readbyqxmd.com/read/28728684/healthful-and-unhealthful-plant-based-diets-and-the-risk-of-coronary-heart%C3%A2-disease-in-u-s-adults
#4
Ambika Satija, Shilpa N Bhupathiraju, Donna Spiegelman, Stephanie E Chiuve, JoAnn E Manson, Walter Willett, Kathryn M Rexrode, Eric B Rimm, Frank B Hu
BACKGROUND: Plant-based diets are recommended for coronary heart disease (CHD) prevention. However, not all plant foods are necessarily beneficial for health. OBJECTIVES: This study sought to examine associations between plant-based diet indices and CHD incidence. METHODS: We included 73,710 women in NHS (Nurses' Health Study) (1984 to 2012), 92,329 women in NHS2 (1991 to 2013), and 43,259 men in Health Professionals Follow-up Study (1986 to 2012), free of chronic diseases at baseline...
July 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28722143/breast-cancer-stem-cells-as-last-soldiers-eluding-therapeutic-burn-a-hard-nut-to-crack
#5
REVIEW
Pritish Nilendu, Ajay Kumar, Azad Kumar, Jayanta K Pal, Nilesh Kumar Sharma
Cancer stem cells (CSCs) are found in many cancer types, including breast carcinoma. Breast cancer stem cells (BCSCs) are considered as seed of cancer formation and they are associated with metastasis and genotoxic drug resistance. Several studies highlighted the presence of BCSCs in tumor microenvironment and they are accentuated with several carcinoma events including metastasis and resistance to genotoxic drugs and they also rebound after genotoxic burn. Stemness properties of a small population of cells in carcinoma have provided clues regarding the role of tumor microenvironment in tumor pathophysiology...
July 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28720626/family-physicians-perceptions-of-electronic-cigarettes-in-tobacco-use-counseling
#6
Samuel Ofei-Dodoo, Rick Kellerman, Kari Nilsen, Ruth Nutting, Douglas Lewis
BACKGROUND: Recent support has been shown for physicians to recommend e-cigarettes to patients who are trying to quit smoking. Supporters of this recommendation argue that e-cigarettes are not combustible products and are less harmful and more effective cessation products than regular cigarettes, with less inherent risk. Those who oppose this idea argue that little reliable evidence suggests that e-cigarettes are better cigarette cessation devices than currently available nicotine replacement therapies, and that they pose as much risk as cigarettes...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28720506/arecoline-activates-latent-transforming-growth-factor-%C3%AE-1-via-mitochondrial-reactive-oxygen-species-in-buccal-fibroblasts-suppression-by-epigallocatechin-3-gallate
#7
Yu-Ping Hsieh, King-Jean Wu, Hsin-Ming Chen, Yi-Ting Deng
BACKGROUND/PURPOSE: Oral submucous fibrosis (OSF) is a premalignant condition caused by the chewing of areca nut (AN). Transforming growth factor β (TGFβ) plays a central role in the pathogenesis of OSF. Connective tissue growth factor (CTGF or CCN2) and early growth response-1 (Egr-1) are important mediators in the fibrotic response to TGFβ in several fibrotic disorders including OSF. Arecoline, a major AN alkaloid, induced the synthesis of CCN2 and Egr-1 in human buccal mucosal fibroblast (BMFs)...
July 15, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28717510/post-obstructive-pulmonary-edema-from-aspirated-nuts
#8
Ahsan Bashir, Sabina Qureshi Ahmad, Joshua Silverman, Emily Concepcion, Haesoon Lee
OBJECTIVES: Post-obstructive pulmonary edema is thought to occur from hemodynamic changes secondary to forced inspiration against the closed airway due to acute or chronic airway obstruction. We report a case of a 13 month-old boy who developed pulmonary edema from aspirated foreign body, nuts. METHODS: He underwent emergency bronchoscopy to confirm the clinical diagnosis of aspirated nuts in the trachea and nuts were removed endoscopically. His trachea was then intubated and he was mechanically ventilated with oxygen...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28715555/application-of-a-lifestyle-based-tool-to-estimate-premature-cardiovascular-disease-events-in-young-adults-the-coronary-artery-risk-development-in-young-adults-cardia-study
#9
Holly C Gooding, Hongyan Ning, Matthew W Gillman, Christina Shay, Norrina Allen, David C Goff, Donald Lloyd-Jones, Stephanie Chiuve
Importance: Few tools exist for assessing the risk for early atherosclerotic cardiovascular disease (ASCVD) events in young adults. Objective: To assess the performance of the Healthy Heart Score (HHS), a lifestyle-based tool that estimates ASCVD events in older adults, for ASCVD events occurring before 55 years of age. Design, Setting, and Participants: This prospective cohort study included 4893 US adults aged 18 to 30 years from the Coronary Artery Risk Development in Young Adults (CARDIA) study...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28713409/phylogenetic-resolution-in-juglans-based-on-complete-chloroplast-genomes-and-nuclear-dna-sequences
#10
Wenpan Dong, Chao Xu, Wenqing Li, Xiaoman Xie, Yizeng Lu, Yanlei Liu, Xiaobai Jin, Zhili Suo
Walnuts (Juglans of the Juglandaceae) are well-known economically important resource plants for the edible nuts, high-quality wood, and medicinal use, with a distribution from tropical to temperate zones and from Asia to Europe and Americas. There are about 21 species in Juglans. Classification of Juglans at section level is problematic, because the phylogenetic position of Juglans cinerea is disputable. Lacking morphological and DNA markers severely inhibited the development of related researches. In this study, the complete chloroplast genomes and two nuclear DNA regions (the internal transcribed spacer and ubiquitin ligase gene) of 10 representative taxa of Juglans were used for comparative genomic analyses in order to deepen the understanding on the application value of genetic information for inferring the phylogenetic relationship of the genus...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28709968/specific-allergen-profiles-of-peanut-foods-and-of-diagnostic-or-therapeutic-allergenic-products
#11
Stephanie Filep, Denise Block, Bryan R E Smith, Eva M King, Scott Commins, Michael Kulis, Brian P Vickery, Martin D Chapman
RATIONALE: 'Generic' immunoassays for peanut cannot discriminate between allergen levels in peanut derived food products or therapeutics. Clinical trials of oral immunotherapy are strengthened by using standardized peanut preparations, with defined doses of major allergens. OBJECTIVE: This paper describes measurement of Ara h 1, Ara h 2 and Ara h 6 in peanut foods and in peanut flour extracts used for allergy diagnosis and oral immunotherapy. METHODS: Monoclonal antibody-based enzyme immunoassays for Ara h 1, Ara h 2 and Ara h 6 were used to compare allergen levels in peanut (n=19) and tree nut (n=16) butter, peanut flour (n=11); oils (n=8); extracts used for diagnosis and oral immunotherapy (n=5); and the National Institute for Standards and Technology Peanut Butter Standard Reference Material® 2387...
July 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28704075/arecoline-cannot-alter-testicular-dysfunction-and-pineal-activation-caused-by-noise-in-wistar-rat
#12
Indraneel Saha, Aniruddha Chatterjee, Urmi Chatterji, B R Maiti
Millions of people consume betel nut for increased capacity to work and for stress reduction. The nut contains arecoline, which has multiple side effects on endocrine functions. Objective of the work is to investigate pineal-testicular responses to noise and after arecoline treatment in noise in rats. Noise exposure (100 dB, 6 h daily, 10 days) caused pineal stimulation ultrastructurally and at indoleamines level. Leydig cell dysfunction with fall of testosterone level and suppression of sex accessories were noticed...
July 13, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28701220/identification-of-qtl-with-large-effect-on-seed-weight-in-a-selective-population-of-soybean-with-genome-wide-association-and-fixation-index-analyses
#13
Long Yan, Nicolle Hofmann, Shuxian Li, Marcio Elias Ferreira, Baohua Song, Guoliang Jiang, Shuxin Ren, Charles Quigley, Edward Fickus, Perry Cregan, Qijian Song
BACKGROUND: Soybean seed weight is not only a yield component, but also a critical trait for various soybean food products such as sprouts, edamame, soy nuts, natto and miso. Linkage analysis and genome-wide association study (GWAS) are two complementary and powerful tools to connect phenotypic differences to the underlying contributing loci. Linkage analysis is based on progeny derived from two parents, given sufficient sample size and biological replication, it usually has high statistical power to map alleles with relatively small effect on phenotype, however, linkage analysis of the bi-parental population can't detect quantitative trait loci (QTL) that are fixed in the two parents...
July 12, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28700962/studies-on-the-structural-changes-during-curing-of-epoxy-and-its-blend-with-ctbn
#14
Kavita Srivastava, Ashwani Kumar Rathore, Deepak Srivastava
Cashew nut shell liquid (CNSL), an agricultural renewable resource material, produces natural phenolic distillates such as cardanol. Cardanol condenses with formaldehyde at the ortho- and para-position of the phenolic ring under acidic or alkaline condition to yield a series of polymers of novolac- or resol-type phenolic resins. These phenolic resins may further be modified by epoxidation with epichlorohydrin to duplicate the performance of such phenolic-type novolacs (CFN). The structural changes during curing of blend samples of epoxy and carboxyl terminated poly (butadiene-co-acrylonitrile) (CTBN) were studies by Fourier-transform infrared (FTIR) spectrophotometer...
July 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28699969/the-effect-of-size-and-density-on-nut-removal-in-syagrus-loefgrenii-glassman-arecaceae-in-the-brazilian-cerrado
#15
J Ragusa-Netto
In this study I tested the effect of Syagrus loefgrenii nut size and number on the intensity of removal by rodents across seasons. Trials were performed in which piles of either small or large endocarps (1, 3, 6, 12, and 25) were subjected to removal by rodents in the Cerrado (Brazilian savanna). Despite of variations in the intensity of removal, always this process decrease conform endocarp number. Also, mean proportion of endocarp removal was unrelated to year period, initial number, and size of endocarps...
July 10, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28697546/development-of-novel-anionic-gemini-surfactants-and-application-in-fabricating-hierarchical-silver-microparticles-for-surface-enhanced-raman-spectroscopy
#16
Yuming Cheng, Xiong Liu, Qiufen Lei, Xuefeng Li, Jinfeng Dong
In this work, a new category of anionic Gemini surfactants with a rigid space, disodium 2,2'-(1, 4-phenylene bis (methylene)) bis (alkane-1-sulfate) (CmArCm, m=8, 10, 12, 14), were developed. They showed excellent surface activity and remarkable micellization tendency in aqueous solutions as measured by the equilibrium surface tension method. It was noticed that both the surface activity and micellization ability of CmArCm were gradually strengthened upon increasing the hydrophobic chain length m. Those Gemini surfactants were employed as capping reagents to fabricate three-dimensional (3D) hierarchical silver microparticles (AgMPs) successfully even in a large-scale of gram-level...
June 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28696394/influence-of-genetic-variations-in-selenoprotein-genes-on-the-pattern-of-gene-expression-after-supplementation-with-brazil-nuts
#17
Janaina L S Donadio, Marcelo M Rogero, Simon Cockell, John Hesketh, Silvia M F Cozzolino
Selenium (Se) is an essential micronutrient for human health. Its beneficial effects are exerted by selenoproteins, which can be quantified in blood and used as molecular biomarkers of Se status. We hypothesize that the presence of genetic polymorphisms in selenoprotein genes may: (1) influence the gene expression of specific selenoproteins and (2) influence the pattern of global gene expression after Brazil nut supplementation. The study was conducted with 130 healthy volunteers in Sao Paulo, Brazil, who consumed one Brazil nut (300 μg/Se) a day for eight weeks...
July 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28696362/trends-of-adherence-to-the-mediterranean-dietary-pattern-in-northern-italy-from-2010-to-2016
#18
Alessandro Leone, Alberto Battezzati, Ramona De Amicis, Giulia De Carlo, Simona Bertoli
Little information is available on the trends of adherence to the Mediterranean dietary pattern (MDP). This study investigates food consumption trends from 2010 to 2016 in subjects living in Northern Italy. A cross-sectional study of 8584 subjects enrolled between January 2010 and December 2016 was conducted. Socio-demographic, nutrition and lifestyle characteristics were collected. A 14-item questionnaire was used to evaluate adherence to MDP. Multivariable Poisson regression was used to evaluate the trends of and the determinants for the adherence to MDP...
July 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28693629/resveratrol-has-dose-dependent-effects-on-dna-fragmentation-and-mitochondrial-activity-of-ovine-secondary-follicles-cultured-in-vitro
#19
T J S Macedo, V R P Barros, A P O Monte, B B Gouveia, M É S Bezerra, A Y P Cavalcante, R S Barberino, V G Menezes, M H T Matos
The worldwide consumption of red wine, nuts and grapes has resulted in increased human exposure to resveratrol, which could affect reproductive function. However, the effect of resveratrol on in vitro culture of early-stage ovarian follicles has never been investigated. The aims of the present study were to evaluate the effect of resveratrol on sheep secondary follicle morphology, growth, DNA fragmentation, intracellular levels of glutathione (GSH) and active mitochondria. Secondary follicles were isolated from the ovaries and cultured for 18 days in supplemented α-MEM+ (control medium) or in control medium containing resveratrol (2, 10 or 30 µM)...
July 11, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28692127/diversity-and-genetic-structure-of-the-native-brazil-nut-tree-bertholletia-excelsa-bonpl-population
#20
J C Cabral, A B Baldoni, H Tonini, V C R Azevedo, L D Giustina, A V Tiago, A A B Rossi
The present study was carried out in a native Brazil nut tree population (Bertholletia excelsa Bonpl., Lecythidaceae) to assess its genetic diversity and structure. Ten microsatellite markers were used to genotype 198 adult trees (B. excelsa). The population presented high genetic diversity and inbreeding absence rates. The empirical Bayesian method showed three distinct groups in the structure of this population. Molecular analysis of variance showed 98% variability within groups, and 2% between groups. The genetic divergence (FST) indicated little difference between groups; thus, suggesting efficient gene flow between the analyzed B...
July 6, 2017: Genetics and Molecular Research: GMR
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