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https://www.readbyqxmd.com/read/29146309/stard13-3-untranslated-region-functions-as-a-cerna-for-tp53inp1-in-prohibiting-migration-and-invasion-of-breast-cancer-cells-by-regulating-mir-125b-activity
#1
Lufeng Zheng, Xiaoman Li, Jinjiang Chou, Chenxi Xiang, Qianqian Guo, Zhiting Zhang, Xinwei Guo, Lanlan Gao, Yingying Xing, Tao Xi
Competitive endogenous messenger RNA (ceRNA) affects transcription of other RNA molecules by competitively binding common microRNAs. Previous studies have shown that TP53INP1 functions as a suppressor in tumor metastasis. Our study elucidated StarD13 messenger RNA as a ceRNA in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated...
November 11, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29142603/expression-and-significance-of-secreted-protein-acidic-and-rich-in-cysteine-in-human-osteosarcoma
#2
Yongkun Yang, Xiaohui Niu, Weifeng Liu, Hairong Xu
Osteosarcoma is the most common primary malignancy of bone, and is a high-grade malignant mesenchymal tumor with high recurrence and metastatic rates. Increased expression of secreted protein, acidic and rich in cysteine (SPARC) indicates poor prognosis in a number of malignances. However, the expression level of SPARC in human osteosarcoma and its associated mechanism remains unclear. To analyze the expression of SPARC in human osteosarcoma and its potential application in the diagnosis and treatment of osteosarcoma, the clinical records and samples of 20 cases of osteosarcoma were collected...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29139094/investigating-the-therapeutic-potential-and-mechanism-of-curcumin-in-breast-cancer-based-on-rna-sequencing-and-bioinformatics-analysis
#3
Rong Wang, Jinbin Li, Yulan Zhao, Yapeng Li, Ling Yin
BACKGROUND: Breast cancer is a prevalent cancer in female. This study aims to investigate the therapeutic potential and mechanism of curcumin in breast cancer. METHODS: After cultivation, human breast cancer cells (MCF-7 cells) were treated with 0.1% (v/v) 15 µmol/ml curcumin-dimethylsulfoxide solution and 0.1% (v/v) dimethylsulfoxide, respectively, at 37 °C and 5% CO2 for 48 h. Total RNA was extracted, cDNA library was constructed, and cDNAs were amplified and sequenced...
November 14, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29135276/effects-of-the-new-york-state-concussion-management-and-awareness-act-lystedt-law-on-concussion-related-emergency-health-care-utilization-among-adolescents-2005-2015
#4
David R Baker, Erin R Kulick, Amelia K Boehme, James M Noble
BACKGROUND: All states have enacted legislation addressing the management of sports-related concussions (SRCs) in adolescent athletes. The effect of these laws on health care utilization is uncertain. Hypothesis/Purpose: The purpose was to evaluate the effects of New York's 2011 Concussion Management and Awareness Act ("Lystedt Law") on emergency department (ED) concussion health care visits (EDCHVs) and brain imaging utilization. It was hypothesized that New York concussion legislation would have a significant temporal effect on EDCHVs...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29129760/the-key-role-of-proinflammatory-cytokines-matrix-proteins-rankl-opg-and-wnt-%C3%AE-catenin-in-bone-healing-of-hip-arthroplasty-patients
#5
Jean Cassuto, Agnetha Folestad, Jan Göthlin, Henrik Malchau, Johan Kärrholm
INTRODUCTION: We still lack understanding of why some implants fail while most remain stable after decades of use. Proinflammatory cytokines, matrix proteins and bone regulating cytokines of the RANKL/OPG (receptor activator of nuclear factor kappa B ligand/osteoprotegerin) and Wnt/β-catenin pathways are mandatory for normal bone repair but their spatial and temporal role in the healing of primary total hip arthroplasties (THA) has not been previously shown. MATERIALS AND METHODS: Twenty-four osteoarthritis patients with one-sided well-fixed primary THA were prospectively monitored during 18years (18Y) with repeated blood samples, clinical variables and radiographs...
November 10, 2017: Bone
https://www.readbyqxmd.com/read/29113221/sparc-inhibits-breast-cancer-bone-metastasis-and-may-be-a-clinical-therapeutic-target
#6
Jingjing Ma, Sheng Gao, Xiju Xie, Erhu Sun, Min Zhang, Qian Zhou, Cheng Lu
Breast cancer is one of the most common types of cancer in females worldwide, and metastasis to bone is an important characteristic of malignancy. The present study aimed to investigate the molecular mechanism of breast cancer to bone metastasis of secreted protein acidic and rich in cysteine (SPARC). Immunohistochemistry was performed to examine the expression of SPARC in primary breast tumors and bone metastatic foci. Western blotting and reverse transcription-quantitative polymerase chain reaction were performed to detect the expression level of SPARC in several types of breast cancer cell...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29101562/academic-status-does-not-affect-outcome-following-complex-hepato-pancreato-biliary-procedures
#7
Maria S Altieri, Jie Yang, Donald Groves, Donglei Yin, Kristen Cagino, Mark Talamini, Aurora Pryor
INTRODUCTION: There is a growing debate regarding outcomes following complex hepato-pancreato-biliary (HPB) procedures. The purpose of our study is to examine if facility type has any impact on complications, readmission rates, emergency department (ED) visit rates, and length of stay (LOS) for patients undergoing HPB surgery. METHODS: The SPARCS administrative database was used to identify patients undergoing complex HPB procedures between 2012 and 2014 in New York...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29077165/role-of-secreted-protein-acidic-in-hematogenous-metastasis-of-gastric-cancer
#8
A Mo, S-W Yang, Y-X Jiang, Y-L Zhao, Y Shi, F Qian, Y-X Hao, P-W Yu
OBJECTIVE: To investigate tumor microenvironment of metastasis (TMEM) and the expression of SPARC (secreted protein acidic and rich in cysteine) in gastric cancer, and their relationships with hematogenous metastasis. PATIENTS AND METHODS: Twenty-six pairs of cases with gastric cancer were enrolled, in which there were 26 cases with distant organ metastases and 26 cases of gastric cancer without organ metastases as controls. TMEM (by double-stained immunohistochemistry) and the expression of SPARC were determined in twenty-six pairs of cases...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29075785/sparc-suppresses-lymph-node-metastasis-by-regulating-the-expression-of-vegfs-in-ovarian-carcinoma
#9
Fenghui Peng, Yanping Zhong, Yunfeng Liu, Yueming Zhang, Yihong Xie, Yingxin Lu, Xinyin Zhang, Danrong Li
Lymph node metastasis is one of the most valuable determinants for the prognosis of ovarian cancer. However, the molecular mechanisms underlying lymphangiogenesis in ovarian cancer is still poorly understood. Secreted protein acidic and rich in cysteine (SPARC), a Ca2+-binding matricellular glycoprotein that modulates cell adhesion, migration and differentiation, is thought to play a decisive role in tumor metastasis. Vascular endothelial growth factor (VEGF)-C and VEGF-D contributes to tumor-associated lymphatic vessel growth, enhancing the metastatic spread of tumor cells to lymph nodes...
December 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29063306/what-happens-to-biliary-colic-patients-in-new-york-state-10-year-follow-up-from-emergency-department-visits
#10
Maria S Altieri, Jie Yang, Chencan Zhu, Samer Sbayi, Konstantinos Spaniolas, Mark Talamini, Aurora Pryor
INTRODUCTION: Biliary colic is a common diagnosis for patients presenting to the emergency department (ED). The purpose of this study is to examine the outcomes of patients coming to the ED with biliary colic. METHODS: The NYS longitudinal SPARCS database was used to identify patients presenting to the ED with biliary colic from 2005 to 2014. Through the use of a unique identifier, patients were followed in NYS across multiple institutions. Patients who were lost to follow-up, with duplicated records, and those that underwent percutaneous cholecystectomy tubes were excluded from the analysis...
October 23, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29048685/mir-504-promotes-tumour-growth-and-metastasis-in-human-osteosarcoma-by-targeting-tp53inp1
#11
Qingchun Cai, Sixiang Zeng, Xing Dai, Junlong Wu, Wei Ma
An increasing number of studies have demonstrated that microRNAs participate in the development of osteosarcoma by acting as tumour suppressor or tumour-promoting genes. We investigated the role of miR-504 in the growth and metastasis of osteosarcoma. The expression of miR-504 in clinical osteosarcoma samples was higher than that in the adjacent normal tissue and correlated with tumour size and clinical stage. Tumour protein p53-inducible nuclear protein 1 (TP53INP1) was downregulated in the clinical osteosarcoma samples compared with the adjacent normal tissues and was consistently correlated with the clinical stage...
September 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29040309/targeted-pth4-expressing-cell-ablation-impairs-skeletal-mineralization-in-zebrafish
#12
Paula Suarez-Bregua, Ankur Saxena, Marianne E Bronner, Josep Rotllant
Skeletal development and mineralization are essential processes driven by the coordinated action of neural signals, circulating molecules and local factors. Our previous studies revealed that the novel neuropeptide Pth4, synthesized by hypothalamic cells, was involved in bone metabolism via phosphate regulation in adult zebrafish. Here, we investigate the role of pth4 during skeletal development using single-cell resolution, two-photon laser ablation of Pth4:eGFP-expressing cells and confocal imaging in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29032244/the-impact-of-sparc-on-age-related-cardiac-dysfunction-and-fibrosis-in-drosophila
#13
Leigh Vaughan, Richard Marley, Sara Miellet, Paul S Hartley
Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are unclear, yet clinically important. Drosophila is amenable to the study of cardiac ageing as well as collagen deposition; however it is unclear whether collagen accumulates in the ageing Drosophila heart. This work examined collagen deposition and cardiac function in ageing Drosophila, in the context of reduced expression of collagen-interacting protein SPARC (Secreted Protein Acidic and Rich in Cysteine) an evolutionarily conserved protein linked with fibrosis...
October 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29028628/role-of-pdgf-bb-in-proliferation-differentiation-and-maintaining-stem-cell-properties-of-pdl-cells-in-vitro
#14
Zornitsa Mihaylova, Rozaliya Tsikandelova, Pavel Sanimirov, Natalia Gateva, Vanyo Mitev, Nikolay Ishkitiev
OBJECTIVE: Platelet-derived growth factor-BB (PDGF-BB) is one of the most abundant growth factors in platelet derived products and has been shown to stimulate regeneration after tissue injury. There is a population of mesenchymal stem cells (MSC) in human periodontal ligament (PDL) which can contribute to tissue regeneration under appropriate conditions. DESIGN: PDL cells were isolated and characterized using stem cell and differentiation markers via immunofluorescence and flow cytometry and then cultured in vitro and treated with different concentrations of PDGF-BB...
September 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29024941/in-depth-proteomic-analysis-of-tissue-interstitial-fluid-for-hepatocellular-carcinoma-serum-biomarker-discovery
#15
Jian Zhang, Ning Hao, Wei Liu, Min Lu, Longqin Sun, Ning Chen, Miantao Wu, Xiaohang Zhao, Baocai Xing, Wei Sun, Fuchu He
BACKGROUND: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. New serum biomarkers for HCC screening are needed, especially for alpha-fetoprotein (AFP) negative patients. As a proximal fluid between body fluids and intracellular fluid, tissue interstitial fluid (TIF) is a suitable source for serum biomarker discovery. METHODS: Sixteen paired TIF samples from HCC tumour and adjacent non-tumour tissues were analysed by isobaric tags for relative and absolute quantitation (iTRAQ) method...
October 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29016436/trends-and-disparities-in-cervical-spine-fusion-procedures-utilization-in-the-new-york-state
#16
Rui Feng, Mark Finkelstein, Khawaja Bilal, Eric K Oermann, Michael Palese, John Caridi
STUDY DESIGN: A retrospective review of the Statewide Planning and Research Cooperative System database of the New York State. OBJECTIVE: This study examined the rate of increase of cervical spine fusion procedures at low-, medium-, and high-volume hospitals, and analyzed racial and socioeconomic characteristics of the patient population treated at these three volume categories. SUMMARY OF BACKGROUND DATA: There has been a steady increase in spinal fusion procedures performed each year in the US, especially cervical and lumbar fusion...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28988962/prehospital-cooling-to-improve-successful-targeted-temperature-management-after-cardiac-arrest-a-randomized-controlled-trial
#17
D C Scales, S Cheskes, P R Verbeek, R Pinto, D Austin, S C Brooks, K N Dainty, K Goncharenko, M Mamdani, K E Thorpe, L J Morrison
RATIONALE: Targeted temperature management (TTM) improves survival with good neurological outcome after out-of-hospital cardiac arrest (OHCA), but is delivered inconsistently and often with delay. OBJECTIVE: To determine if prehospital cooling by paramedics leads to higher rates of 'successful TTM', defined as achieving a target temperature of 32-34°C within 6h of hospital arrival. METHODS: Pragmatic RCT comparing prehospital cooling (surface ice packs, cold saline infusion, wristband reminders) initiated 5min after return of spontaneous circulation (ROSC) versus usual resuscitation and transport...
October 5, 2017: Resuscitation
https://www.readbyqxmd.com/read/28982537/collagen-iv-trafficking-the-inside-out-and-beyond-story
#18
REVIEW
Alexa Chioran, Sebastian Duncan, Andrew Catalano, Theodore J Brown, Maurice J Ringuette
Collagen IV networks endow basement membranes (BMs) with remarkable tensile strength and function as morphoregulatory substrata for diverse tissue-specific developmental events. A complex repertoire of intracellular and extracellular molecular interactions are required for collagen IV secretion and supramolecular assembly into BMs. These include intracellular chaperones such as Heat shock protein 47 (Hsp47) and the chaperone-binding trafficking protein Transport and Golgi organization protein 1 (Tango1). Mutations in these proteins lead to compromised collagen IV protomer stability and secretion, leading to defective BM assembly and function...
November 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28969021/secreted-protein-acidic-and-rich-in-cysteine-sparc-induces-cell-migration-and-epithelial-mesenchymal-transition-through-wnk1-snail-in-non-small-cell-lung-cancer
#19
Jen-Yu Hung, Meng-Chi Yen, Shu-Fang Jian, Cheng-Ying Wu, Wei-An Chang, Kuan-Ting Liu, Ya-Ling Hsu, Inn-Wen Chong, Po-Lin Kuo
The extracellular matrix is a component of physiological microenvironment and a regulator of cellular processes such as migration and proliferation. Secreted Protein Acidic and Rich in Cysteine (SPARC/osteonectin) is an extracellular matrix-associated glycoprotein involved in the regulation of cell proliferation and cell migration in several types of cancers. However, the role of SPARC in lung cancer is paradoxical and details of the regulatory mechanism are not well-known. In this study, we investigated novel SPARC-mediated signaling pathways...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28962925/spp1-rs4754-and-its-epistatic-interactions-with-sparc-polymorphisms-in-gastric-cancer-susceptibility
#20
Le-Zong Chen, Cai-Yun He, Xuan Su, Jun-Ling Peng, Dong-Liang Chen, Zulu Ye, Dong-Dong Yang, Zi-Xian Wang, Feng Wang, Jian-Yong Shao, Rui-Hua Xu
The matricellular glycoprotein products of the SPP1 and SPARC genes play critical roles in many aggressive tumor phenotypes including gastric cancer. We sought to test whether the polymorphisms of these two genes, individually or jointly, influence gastric cancer susceptibility. Nine potentially functional, tagging single nucleotide polymorphisms (tagSNPs) of SPP1 and SPARC were selected and detected using the Kompetitive Allele Specific PCR method in 301 gastric cancer cases and 1441 healthy control subjects...
January 15, 2018: Gene
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