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https://www.readbyqxmd.com/read/28505082/supervised-clustering-of-adipokines-and-hormonal-receptors-predict-prognosis-in-a-population-of-obese-women-with-type-1-endometrial-cancer
#1
Jennifer Uzan, Enora Laas, Issam Abd Alsamad, Dounia Skalli, Dhouha Mansouri, Bassam Haddad, Cyril Touboul
Obesity is a major risk factor for endometrial cancer (EC). Yet, its impact on prognosis is controversial. Obesity is associated with metabolic and hormonal dysregulation as well as adipokines increase. The aim of this study was to characterize the expression of biological factors related to obesity within the tumor and evaluate their impact on prognosis. One hundred and thirty-six patients, including 55 obese patients, with endometrioid type I EC operated by total hysterectomy were included in this retrospective study conducted in a Tertiary teaching hospital between 2000 and 2013...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28499910/sparc-paucity-alleviates-superoxide-mediated-oxidative-stress-apoptosis-and-autophagy-in-diabetogenic-hepatocytes
#2
Kanikkai Raja Aseer, Allwin Jennifa Silvester, Anuj Kumar, Myung-Sook Choi, Jong Won Yun
Secreted protein acidic and rich in cysteine (SPARC) is known to play a previously unappreciated role in diabetes, but its precise mechanism in liver/hepatocyte pathology remains unknown. Inhibition of SPARC is critical in resolving candidate pathogenic events such as production of reactive oxygen species (ROS), which are broadly considered for their roles in diabetes, and is capable of protecting functional hepatocytes. Here, we provide in vitro and in vivo evidence demonstrating pathological correlations between SPARC and streptozotocin (STZ)-induced diabetic rat livers as well as cultured hepatocytes induced by diabetogenic stimuli...
May 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28496027/expression-profile-of-matricellular-proteins-in-hypertrophied-right-ventricle-of-monocrotaline-induced-pulmonary-hypertensive-rats
#3
Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawaki
Matricellular proteins, a non-structural extracellular matrix (ECM) component, bind to and modulate various molecules including growth factor, cytokine, protease, other ECM components and cell membrane receptors. While most matricellular proteins are hardly expressed in normal adult tissue, they are re-expressed in heart tissue during cardiac diseases. The present study aimed to clarify the mRNA expression profile of matricellular proteins [secreted protein acidic and rich in cysteine: SPARC, hevin, thrombospondin (TSP)-1, -2 and -4, CCN1 and 5, tenascin (Tn)C and N, periostin and osteopontin (OPN)] in hypertrophied right ventricle (RV) of monocrotaline (MCT)-induced pulmonary hypertensive rats...
May 11, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28482007/molecular-biomarkers-for-weight-control-in-obese-individuals-subjected-to-a-multi-phase-dietary-intervention
#4
Jennifer Bolton, Emilie Montastier, Jérôme Carayol, Sophie Bonnel, Lucile Mir, Marie-Adeline Marques, Arne Astrup, Wim Saris, Jason Iacovoni, Nathalie Villa-Vialaneix, Armand Valsesia, Dominique Langin, Nathalie Viguerie
Context: While calorie restriction has proven beneficial for weight loss, long-term weight control is variable between individuals. Objective: To identify biomarkers of successful weight control during a dietary intervention (DI). Design, Setting, and Participants: Adipose tissue (AT) transcriptomes were compared between 21 obese individuals that either maintained weight loss or regained weight during the DI. Results were validated on 310 individuals from the same study using RT-qPCR, and protein levels of potential circulating biomarkers measured by ELISA...
May 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28463901/a-mechanism-underlying-preventive-effect-of-high-intensity-training-on-colon-cancer
#5
Kaori Matsuo, Koji Sato, Ken Suemoto, Eri Miyamoto-Mikami, Noriyuki Fuku, Kazuhiko Higashida, Katsunori Tsuji, Yuzhong Xu, Xin Liu, Motoyuki Iemitsu, Takafumi Hamaoka, Izumi Tabata
INTRODUCTION: We examined effects of high intensity training on chemically induced aberrant crypt foci (ACF) in rat colon. We also investigated mechanisms that may underlie the results obtained, with a focus on secreted protein acidic and rich in cysteine (SPARC), which has been proposed as an exercise-related factor of colon cancer prevention. METHODS: After an administration of 1,2-dimethylhydrazine (DMH), F344 rats executed high-intensity intermittent swimming training (HIIST) (twelve 20-sec swimming with a weight [16% body weight] with 10-sec pauses between the bouts) 5 days/week for 4 weeks...
May 2, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28457985/validation-of-aspirin-response-related-transcripts-in-patients-with-coronary-artery-disease-and-preliminary-investigation-on-cmtm5-function
#6
J W Zhang, T F Liu, X H Chen, W Y Liang, X R Feng, L Wang, Sidney W Fu, Timothy A McCaffrey, M L Liu
Aspirin is widely used in the prevention of cardiovascular diseases, but the antiplatelet responses vary from one patient to another. To validate aspirin response related transcripts and illustrate their roles in predicting cardiovascular events, we have quantified the relative expression of 14 transcripts previously identified as related to high on-aspirin platelet reactivity (HAPR) in 223 patients with coronary artery disease (CAD) on regular aspirin treatment. All patients were followed up regularly for cardiovascular events (CVE)...
April 27, 2017: Gene
https://www.readbyqxmd.com/read/28456743/does-objective-quality-of-physicians-correlate-with-patient-satisfaction-measured-by-hospital-compare-metrics-in-new-york-state
#7
Kimon Bekelis, Symeon Missios, Todd A MacKenzie, Patrick M O'Shaughnessy
BACKGROUND: It is unclear whether publicly reported benchmarks correlate with the quality of physicians and institutions. We investigated the association of patient satisfaction measures from a public reporting platform with the performance of neurosurgeons in New York State. METHODS: We performed a cohort study involving patients undergoing neurosurgical operations from 2009-2013, who were registered in the Statewide Planning and Research Cooperative System (SPARCS) database...
April 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28439016/astrocytes-locally-translate-transcripts-in-their-peripheral-processes
#8
Kristina Sakers, Allison M Lake, Rohan Khazanchi, Rebecca Ouwenga, Michael J Vasek, Adish Dani, Joseph D Dougherty
Local translation in neuronal processes is key to the alteration of synaptic strength necessary for long-term potentiation, learning, and memory. Here, we present evidence that regulated de novo protein synthesis occurs within distal, perisynaptic astrocyte processes. Astrocyte ribosomal proteins are found adjacent to synapses in vivo, and immunofluorescent detection of peptide elongation in acute slices demonstrates robust translation in distal processes. We have also developed a biochemical approach to define candidate transcripts that are locally translated in astrocyte processes...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28435518/sparc-overexpression-alters-microrna-expression-profiles-involved-in-tumor-progression
#9
Bhavesh K Ahir, Nasya M Elias, Sajani S Lakka
Medulloblastoma is the most common malignant brain tumor in children. SPARC (secreted protein acidic and rich in cysteine), a multicellular non-structural glycoprotein is known to be involved in multiple processes in various cancers. Previously, we reported that SPARC expression significantly impairs medulloblastoma tumor growth in vitro and in vivo and also alters chemo sensitivity. MicroRNAs are a class of post-transcriptional gene regulators with critical functions in tumor progression. In addition, microRNA (miRNA) expression changes are also involved in chemo-resistance...
January 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28433772/mesenchymal-stem-cells-induce-epithelial-to-mesenchymal-transition-in-colon-cancer-cells-through-direct-cell-to-cell-contact
#10
Hidehiko Takigawa, Yasuhiko Kitadai, Kei Shinagawa, Ryo Yuge, Yukihito Higashi, Shinji Tanaka, Wataru Yasui, Kazuaki Chayama
We previously reported that in an orthotopic nude mouse model of human colon cancer, bone marrow-derived mesenchymal stem cells (MSCs) migrated to the tumor stroma and promoted tumor growth and metastasis. Here, we evaluated the proliferation and migration ability of cancer cells cocultured with MSCs to elucidate the mechanism of interaction between cancer cells and MSCs. Proliferation and migration of cancer cells increased following direct coculture with MSCs but not following indirect coculture. Thus, we hypothesized that direct contact between cancer cells and MSCs was important...
May 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28425924/roles-of-copper-binding-proteins-in-breast-cancer
#11
REVIEW
Stéphanie Blockhuys, Pernilla Wittung-Stafshede
Copper ions are needed in several steps of cancer progression. However, the underlying mechanisms, and involved copper-binding proteins, are mainly elusive. Since most copper ions in the body (in and outside cells) are protein-bound, it is important to investigate what copper-binding proteins participate and, for these, how they are loaded with copper by copper transport proteins. Mechanistic information for how some copper-binding proteins, such as extracellular lysyl oxidase (LOX), play roles in cancer have been elucidated but there is still much to learn from a biophysical molecular viewpoint...
April 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28422762/silencing-smoc2-ameliorates-kidney-fibrosis-by-inhibiting-fibroblast-to-myofibroblast-transformation
#12
Casimiro Gerarduzzi, Ramya K Kumar, Priyanka Trivedi, Amrendra K Ajay, Ashwin Iyer, Sarah Boswell, John N Hutchinson, Sushrut S Waikar, Vishal S Vaidya
Secreted modular calcium-binding protein 2 (SMOC2) belongs to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins whose members are known to modulate cell-matrix interactions. We report that SMOC2 is upregulated in the kidney tubular epithelial cells of mice and humans following fibrosis. Using genetically manipulated mice with SMOC2 overexpression or knockdown, we show that SMOC2 is critically involved in the progression of kidney fibrosis. Mechanistically, we found that SMOC2 activates a fibroblast-to-myofibroblast transition (FMT) to stimulate stress fiber formation, proliferation, migration, and extracellular matrix production...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28411351/simultaneous-resection-for-synchronous-colorectal-liver-metastasis-the-new-standard-of-care
#13
Jonathan S Abelson, Fabrizio Michelassi, Tianyi Sun, Jialin Mao, Jeffrey Milsom, Benjamin Samstein, Art Sedrakyan, Heather L Yeo
BACKGROUND: Optimal surgical management for patients with synchronous colorectal cancer liver metastasis is controversial. We provide an analysis of surgical utilization and outcomes for patients presenting with synchronous colon and rectal cancer liver metastasis between simultaneous and staged approaches. METHODS: SPARCS database was used to follow patients undergoing surgery for colorectal cancer with liver metastases from 2005 to 2014. Using International Classification of Diseases, Ninth Revision codes, we identified patients undergoing staged and simultaneous resection...
April 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28382397/does-scope-of-practice-correlate-with-the-outcomes-of-craniotomy-for-tumor-resection-in-children
#14
Symeon Missios, Kimon Bekelis
BACKGROUND: The relationship of scope of practice (predominantly adult, versus predominantly pediatric) with the outcomes of brain tumor surgery in children remains uncertain. We investigated the association of practice focus with the outcomes of neurosurgical oncology operations in pediatric patients. METHODS: We performed a cohort study of all pediatric patients (younger than 18 years old) who underwent craniotomies for tumor resections from 2009 to 2013 and were registered in the Statewide Planning and Research Cooperative System (SPARCS) database...
June 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28371333/behavior-of-prostate-cancer-cells-in-a-nanohydroxyapatite-collagen-bone-scaffold
#15
Susana Cruz-Neves, Nilza Ribeiro, Inês Graça, Carmen Jerónimo, Susana R Sousa, Fernando J Monteiro
Prostate cancer (PCa) is the second leading cause of death among men in Europe and U.S. The metastatic dissemination pattern of PCa is unique, developing bone metastasis as the only site of progression, consequently with a prognosis very poor. The cancer cells interactions within the surrounding bone environment are critical for tumor growth and progression. Secreted protein, acidic and rich in cysteine (SPARC) is described to be involved in PCa cells migration and invasion into bone. Three-dimensional (3D) in vitro systems that are able to closely resemble the in vivo microenvironment are recently taking importance in cancer research...
March 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28363815/proteomic-profiling-of-isogenic-primary-and-metastatic-medulloblastoma-cell-lines-reveals-differential-expression-of-key-metastatic-factors
#16
Shuo Gu, Kai Chen, Minzhi Yin, Zhixiang Wu, Yeming Wu
Medulloblastoma is the most common malignant brain tumor in children. Around 30% of medulloblastoma patients are diagnosed with metastasis, which often results in a poor prognosis. Unfortunately, molecular mechanisms of medulloblastoma metastasis remain largely unknown. In this study, we employed the recently developed deep proteome analysis approach to quantitatively profile the expression of >10,000 proteins from CHLA-01-MED and CHLA-01R-MED isogenic cell lines derived from the primary and metastatic tumor of the same patient diagnosed with a group IV medulloblastoma...
March 28, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28356709/the-sparc-related-modular-calcium-binding-protein-2-smoc2-gene-polymorphism-in-primary-glaucoma-a-case-control-study
#17
Najwa Al-Dabbagh, Hamoud Al-Shahrani, Nourah Al-Dohayan, Md Mustafa, Misbahul Arfin, Abdulrahman K Al-Asmari
Primary glaucomas are among the most common eye diseases that may potentially result in bilateral blindness. Both genetics and environmental factors are reported to be involved in the etiology of primary glaucomas. Secreted protein acidic and rich in cysteine (SPARC)-related modular calcium binding protein 2 (SMOC2) is a matricellular glycoprotein encoded by the SMOC2 gene and known to regulate the expression of extracellular matrix (ECM) proteins and matrix metalloproteinases (MMPs), which play an important role in the pathogenesis of primary glaucomas...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28342122/impact-of-secreted-protein-acidic-and-rich-in-cysteine-sparc-expression-on-prognosis-after-surgical-resection-for-biliary-carcinoma
#18
Kazuhiro Toyota, Yoshiaki Murakami, Naru Kondo, Kenichiro Uemura, Naoya Nakagawa, Shinya Takahashi, Taijiro Sueda
BACKGROUND: Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that influences chemotherapy effectiveness and prognosis. The aim of this study was to investigate whether SPARC expression correlates with the postoperative survival of patients treated with surgical resection for biliary carcinoma. METHODS: SPARC expression in resected biliary carcinoma specimens was investigated immunohistochemically in 175 patients. The relationship between SPARC expression and prognosis after surgery was evaluated using univariate and multivariate analyses...
March 24, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28324731/basement-membranes
#19
Ranjay Jayadev, David R Sherwood
Basement membranes (BMs) are thin, dense sheets of specialized, self-assembled extracellular matrix that surround most animal tissues (Figure 1, top). The emergence of BMs coincided with the origin of multicellularity in animals, suggesting that they were essential for the formation of tissues. Their sheet-like structure derives from two independent polymeric networks - one of laminin and one of type IV collagen (Figure 1, bottom). These independent collagen and laminin networks are thought to be linked by several additional extracellular matrix proteins, including nidogen and perlecan (Figure 1, bottom)...
March 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28320530/single-cell-rna-sequence-analysis-of-mouse-glomerular-mesangial-cells-uncovers-mesangial-cell-essential-genes
#20
Yuqiu Lu, Yuting Ye, Qianqian Yang, Shaolin Shi
Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms underlying these roles are not well understood. Here, we performed a single-cell RNA-sequence (RNA-seq) analysis of mouse mesangial cells using the Fluidigm C1 platform. We found that gene expression in individual mesangial cells was tremendously heterogeneous, with mean correlation coefficients of 0.20, and most mesangial genes were actually expressed in only a portion of mesangial cells and are therefore presumably dispensable...
March 17, 2017: Kidney International
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