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https://www.readbyqxmd.com/read/29778610/a-decade-of-tevar-in-new-york-state-volumes-outcomes-and-implications-for-the-dissemination-of-endovascular-technology
#1
Jordan R Stern, Tianyi Sun, Jialin Mao, Art Sedrakyan, Andrew J Meltzer
INTRODUCTION: /Objectives: The purpose of this study was to characterize utilization and outcomes of TEVAR in New York State during the first decade of commercial availability, with respect to evolving indications, results, and costs. Of specific interest was evaluation of the volume-outcome relationship for this relatively uncommon procedure. METHODS: The New York Statewide Planning and Research Cooperative System (SPARCS) database was queried to identify patients undergoing TEVAR from 2005-2014 for aortic dissection (AD), non-ruptured aneurysm (NRA), and ruptured aneurysm (RA)...
May 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29778400/stromal-heterogeneity-in-pancreatic-cancer-and-chronic-pancreatitis
#2
Lena Haeberle, Katja Steiger, Anna Melissa Schlitter, Sami Alexander Safi, Wolfram Trudo Knoefel, Mert Erkan, Irene Esposito
BACKGROUND/OBJECTIVES: An abundant stromal reaction is a hallmark of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). The cells mainly responsible for the stromal reaction are activated pancreatic stellate cells (PSCs). Despite their crucial role, PSCs are not well characterized. PSCs share characteristics with the better-known hepatic stellate cells (HSCs). The aim of this study was a detailed analysis of PSCs in PDAC and CP. METHODS: Whole-slide specimens of CP (n = 12) and PDAC (n = 10) were studied by histochemistry and immunohistochemistry...
May 12, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29755121/assessment-of-contrast-sensitivity-by-spaeth-richman-contrast-sensitivity-test-and-pelli-robson-chart-test-in-patients-with-varying-severity-of-glaucoma
#3
Sahil Thakur, Parul Ichhpujani, Suresh Kumar, Ravneet Kaur, Sunandan Sood
PURPOSE: This study was designed to assess the efficacy, reliability and repeatability of SPARCS (Spaeth Richman Contrast Sensitivity Test) as compared to the conventional Pelli Robson Chart Test for the assessment of contrast sensitivity in patients with glaucoma. MATERIALS AND METHODS: We evaluated 135 eyes of 135 patients who were age and sex matched into three groups (controls, disc suspects and glaucoma) of 45 patients each. The glaucoma subgroup was further divided into subgroups of mild, moderate and severe based on the visual field damage...
May 14, 2018: Eye
https://www.readbyqxmd.com/read/29739725/surgical-outcomes-for-patients-diagnosed-with-dementia-a-coarsened-exact-matching-study
#4
REVIEW
Kimon Bekelis, Symeon Missios, Joel Shu, Todd A MacKenzie, Bruce Mayerson
BACKGROUND: An increasing number of elderly patients with dementia are undergoing surgical operations. Little is known about the differential impact of dementia on surgical outcomes. We investigated whether demented patients undergoing surgical operations have worse outcomes than their non-demented counterparts. METHODS: We performed a cohort study of all patients undergoing a series of surgical operations who were registered in the New York Statewide Planning and Research Cooperative System (SPARCS) database from 2009 to 2013...
May 5, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29732051/dual-targeting-biomimetic-delivery-for-anti-glioma-activity-via-remodeling-the-tumor-microenvironment-and-directing-macrophage-mediated-immunotherapy
#5
Pengfei Zhao, Yonghui Wang, Xuejia Kang, Aihua Wu, Weimin Yin, Yisi Tang, Jinyu Wang, Meng Zhang, Yifei Duan, Yongzhuo Huang
Tumor-associated macrophages (TAMs) are the major components in the tumor microenvironment (TME). The polarization from the protumor M2 (TAM2) to antitumor M1 (TAM1) phenotype can not only lift the immunosuppressive constraints and elicit cytotoxic T-cell immunity but also augment the chemotherapy efficacy. However, the treatment feasibility by TAM modulation in brain tumors and the mechanisms remained unknown. A dual-targeting biomimetic codelivery and treatment strategy was developed for anti-glioma activity...
March 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29730504/sparc-preserves-endothelial-glycocalyx-integrity-and-protects-against-adverse-cardiac-inflammation-and-injury-during-viral-myocarditis
#6
Marieke Rienks, Paolo Carai, Jurgen van Teeffelen, Bart Eskens, Wouter Verhesen, Bianca Hemmeryckx, Daniel M Johnson, Rick van Leeuwen, Elizabeth A Jones, Stephane Heymans, Anna-Pia Papageorgiou
Myocardial damage as a consequence of cardiotropic viruses leads to a broad variety of clinical presentations and is still a complicated condition to diagnose and treat. Whereas the extracellular matrix protein Secreted Protein Acidic and Rich in Cysteine or SPARC has been implicated in hypertensive and ischemic heart disease by modulating collagen production and cross-linking, its role in cardiac inflammation and endothelial function is yet unknown. Absence of SPARC in mice resulted in increased cardiac inflammation and mortality, and reduced cardiac systolic function upon coxsackievirus-B3 induced myocarditis...
May 3, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29726090/gene-expression-signatures-prognostic-for-relapse-in-stage-i-testicular-germ-cell-tumors-tgct
#7
Jeremy Lewin, Laleh Soltan Ghoraie, Philippe L Bedard, Robert J Hamilton, Peter Chung, Malcolm Moore, Michael A S Jewett, Lynn Anson-Cartwright, Carl Virtanen, Neil Winegarden, Julie Tsao, Padraig Warde, Joan Sweet, Benjamin Haibe-Kains, Aaron R Hansen
OBJECTIVES: To identify differentially expressed genes between relapsed (R) and non-relapsed (NR) clinical stage I (CSI) testicular germ cell tumor (TGCT). MATERIALS AND METHODS: We reviewed patients with CSI non-seminoma(NS) and seminoma(S) from an institutional database (2000-2012) managed by active surveillance. NR-NS and NR-S patients were defined as being relapse free after 2 and 3 years of surveillance respectively. RNA extraction and gene expression analysis was performed on archival primary tumor samples and Gene-Set-Enrichment-Analysis (GSEA) was conducted in order to identify differentiating biological pathways...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29725448/clinical-significance-of-secreted-protein-acidic-and-cysteine-rich-gene-expression-in-patients-with-stage-ii-iii-gastric-cancer-following-curative-resection-and-adjuvant-chemotherapy-with-s-1
#8
Yoshihiro Suzuki, Takashi Oshima, Kazue Yoshihara, Kentaro Sakamaki, Toru Aoyama, Haruhiko Cho, Manabu Shiozawa, Takaki Yoshikawa, Yasushi Rino, Toshio Imada, Munetaka Masuda
The standard treatment for stage II/III gastric cancer is surgical resection followed by adjuvant chemotherapy with fluoropyrimidine anticancer agents, including S-1. The protein, secreted protein, acidic and cysteine-rich (SPARC), promotes angiogenesis, and the proliferation and migration of cancer cells. The present study evaluated the significance of expression of the SPARC gene in patients with stage II/III gastric cancer who had undergone surgical resection and adjuvant chemotherapy with S-1. In the present study, reverse transcription-quantitative polymerase chain reaction was performed in order to quantify mRNA expression levels of SPARC in cancer tissues and adjacent normal mucosa obtained from 134 patients with stage II/III gastric cancer who had undergone surgical resection followed by adjuvant chemotherapy with S-1...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29701683/the-incorporation-of-strontium-to-improve-bone-regeneration-ability-of-mesoporous-bioactive-glasses
#9
Sonia Fiorilli, Giulia Molino, Carlotta Pontremoli, Giorgio Iviglia, Elisa Torre, Clara Cassinelli, Marco Morra, Chiara Vitale-Brovarone
Over the recent years, mesoporous bioactive glasses (MBGs) gained interest as bone regeneration systems, due to their excellent bioactivity and ability to release therapeutic molecules. In order to improve the bone regeneration ability of MBGs, the incorporation of Sr2+ ions, due to its recognized pro-osteogenenic potential, represents a very promising strategy. In this study, MBGs based on the SiO₂⁻CaO system and containing different percentages (2 and 4 mol %) of strontium were prepared by two synthesis methods, in the form of microspheres and nanoparticles...
April 26, 2018: Materials
https://www.readbyqxmd.com/read/29698405/mining-co-occurrence-and-sequence-patterns-from-cancer-diagnoses-in-new-york-state
#10
Yu Wang, Wei Hou, Fusheng Wang
The goal of this study is to discover disease co-occurrence and sequence patterns from large scale cancer diagnosis histories in New York State. In particular, we want to identify disparities among different patient groups. Our study will provide essential knowledge for clinical researchers to further investigate comorbidities and disease progression for improving the management of multiple diseases. We used inpatient discharge and outpatient visit records from the New York State Statewide Planning and Research Cooperative System (SPARCS) from 2011-2015...
2018: PloS One
https://www.readbyqxmd.com/read/29685993/osteoblast-differentiation-of-equine-induced-pluripotent-stem-cells
#11
Arabella Baird, Timothy Lindsay, Alice Everett, Valentine Iyemere, Yasmin Z Paterson, Alyce McClellan, Frances M D Henson, Deborah J Guest
Bone fractures occur in horses following traumatic and non-traumatic (bone overloading) events. They can be difficult to treat due to the need for the horse to bear weight on all legs during the healing period. Regenerative medicine to improve fracture union and recovery could significantly improve horse welfare.Equine induced pluripotent stem cells (iPSCs) have previously been derived. Here we show that equine iPSCs cultured for 21 days in osteogenic induction media on an OsteoAssay surface upregulate the expression of osteoblast associated genes and proteins, including COL1A1 , SPARC , SPP1 , IBSP , RUNX2 and BGALP We also demonstrate that iPSC-osteoblasts are able to produce a mineralised matrix with both calcium and hydroxyapatite deposition...
April 23, 2018: Biology Open
https://www.readbyqxmd.com/read/29684373/racial-disparity-in-utilization-of-high-volume-hospitals-for-surgical-treatment-of-esophageal-cancer
#12
Sadiq S Rehmani, Bian Liu, Adnan Al-Ayoubi, Wissam Raad, Raja M Flores, Faiz Bhora, Emanuela Taioli
BACKGROUND: Utilization of high-volume hospitals (HVH) for esophagectomy has been associated with improved perioperative outcomes and reduced mortality. We aimed to test the hypothesis that black-white racial disparities exist in HVH utilization, and to identify predictors of in-hospital surgical outcomes of esophageal cancer while adjusting for HVH utilization patterns. METHODS: We queried the New York Statewide Planning and Research Cooperative System (SPARCS) database (1995-2012) for esophageal cancer patients who underwent surgical resection exclusively...
April 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29660567/summary-of-expression-of-sparc-protein-in-cutaneous-vascular-neoplasms-and-mimickers
#13
Shakuntala H Mauzo, Denái R Milton, Victor G Prieto, Carlos A Torres-Cabala, Wei-Lien Wang, Nitin Chakravarti, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Robert E Brown, Phyu P Aung
BACKGROUND: Serum protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein, which regulates cell proliferation and facilitates intracellular transport of albumin bound particles including chemotherapeutic agents such as Nab-paclitaxel/ABI-007. Therefore the presence of SPARC may achieve higher intra-tumoral drug concentration with lower dosage and thus reduce systemic side-effects. Several trials of ABI-007, in melanoma, show promising clinical activity. DESIGN: Fifty-four cases of dermal based neoplasms were retrieved including 24 angiosarcomas (AS), 10 hemangiomas, 9 nodular melanomas, 4 Kaposi sarcomas (KS), 3 leiomyosarcomas (LMS), 3 atypical fibroxanthomas (AFX) and 1 spindle cell squamous cell carcinoma (SSCC)...
March 15, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29604793/compact-and-tunable-focusing-device-for-plasma-wakefield-acceleration
#14
R Pompili, M P Anania, E Chiadroni, A Cianchi, M Ferrario, V Lollo, A Notargiacomo, L Picardi, C Ronsivalle, J B Rosenzweig, V Shpakov, A Vannozzi
Plasma wakefield acceleration, either driven by ultra-short laser pulses or electron bunches, represents one of the most promising techniques able to overcome the limits of conventional RF technology and allows the development of compact accelerators. In the particle beam-driven scenario, ultra-short bunches with tiny spot sizes are required to enhance the accelerating gradient and preserve the emittance and energy spread of the accelerated bunch. To achieve such tight transverse beam sizes, a focusing system with short focal length is mandatory...
March 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29589497/risk-factors-for-recurrent-instability-or-revision-surgery-following-arthroscopic-bankart-repair
#15
S A Mahure, B Mollon, B M Capogna, J D Zuckerman, Y W Kwon, A S Rokito
Aims The factors that predispose to recurrent instability and revision stabilization procedures after arthroscopic Bankart repair for anterior glenohumeral instability remain unclear. We sought to determine the rate and risk factors associated with ongoing instability in patients undergoing arthroscopic Bankart repair for instability of the shoulder. Materials and Methods We used the Statewide Planning and Research Cooperative System (SPARCS) database to identify patients with a diagnosis of anterior instability of the shoulder undergoing arthroscopic Bankart repair between 2003 and 2011...
March 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29587245/mitochondrial-ros-cause-motor-deficits-induced-by-synaptic-inactivity-implications-for-synapse-pruning
#16
Eva Sidlauskaite, Jack W Gibson, Ian L Megson, Philip D Whitfield, Artak Tovmasyan, Ines Batinic-Haberle, Michael P Murphy, Peter R Moult, James N Cobley
Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown. To begin to unravel whether mitochondrial ROS regulate pruning, we made the local consequences of neuromuscular junction (NMJ) pruning detectable as motor deficits by using disparate exogenous and endogenous models to induce synaptic inactivity en masse in developing Xenopus laevis tadpoles...
March 20, 2018: Redox Biology
https://www.readbyqxmd.com/read/29580448/hospital-admissions-mortality-and-comorbidities-among-new-york-state-sickle-cell-patients-2005-2013
#17
Elizabeth Linton, Arielle L Langer, Jeffrey Glassberg
Analyses of administrative and large data sources in Sickle Cell Disease (SCD) can answer questions not suitable for prospective study but have been hampered by lack of validated methods to adjust for individual comorbidities and lack of baseline utilization data over time. We sought to develop a database to characterize inpatient SCD care across New York State and generate a re-weighted sickle-cell specific Charlson Comorbidity index (S-CCI) for use in future large data SCD research. We identified 18,541 individual SCD patients admitted to New York State hospitals between 2005 and 2013 from the SPARCS database...
April 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29579013/the-impact-of-comorbid-mental-health-disorders-on-complications-following-cervical-spine-surgery-with-minimum-2-year-surveillance
#18
Bassel G Diebo, Joshua D Lavian, Shian Liu, Neil V Shah, Daniel P Murray, George A Beyer, Frank A Segreto, Fenizia Maffucci, Gregory W Poorman, Denis Cherkalin, Barrett Torre, Dennis Vasquez-Montes, Hiroyuki Yoshihara, Daniel Cukor, Qais Naziri, Peter G Passias, Carl B Paulino
STUDY DESIGN: Retrospective Analysis OBJECTIVE.: To improve understanding of the impact of comorbid mental health disorders on long-term outcomes following cervical spinal fusion in cervical radiculopathy (CR) or cervical myelopathy (CM) patients. SUMMARY OF BACKGROUND DATA: Subsets of patients with CR and CM have mental health disorders, and their impact on surgical complications is poorly understood. METHODS: Patients admitted from 2009-2013 with CR or CM diagnoses who underwent cervical surgery with minimum 2-year surveillance were retrospectively reviewed using New York State's Statewide Planning and Research Cooperative System (SPARCS)...
March 23, 2018: Spine
https://www.readbyqxmd.com/read/29570171/factors-associated-with-health-care-utilization-of-recurrent-clostridium-difficile-infection-in-new-york-state
#19
Steven N Mathews, Ryan Lamm, Jie Yang, Jihye Park, Demetrios Tzimas, Jonathan M Buscaglia, Aurora Pryor, Mark Talamini, Dana Telem, Juan C Bucobo
BACKGROUND: The incidence of infection due to Clostridium difficile infection (CDI) and subsequent economic burden are substantial. GOALS: The impact of changing practice patterns on demographics at risk and utilization of health care resources for recurrence of CDI remains unclear. STUDY: A total of 291,163 patients hospitalized for CDI were identified from 1995 to 2014 from the New York SPARCS database. The χ test, the Welch t test, and multivariable logistic regression analysis were performed to evaluate factors related to readmission...
March 21, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29558210/matricellular-proteins-play-a-potential-role-in-acute-primary-angle-closure
#20
Jing Wang, Mingshui Fu, Kun Liu, Ning Wang, Zhihua Zhang, Minwen Zhou, Xun Xu
PURPOSE: To quantify levels of matricellular proteins in aqueous humor samples from acute primary angle closure (APAC) and non-glaucomatous cataract eyes and investigate their correlation with intraocular pressure (IOP) fluctuation. MATERIALS AND METHODS: Aqueous humor samples were collected from 63 eyes including 29 current APAC eyes, 12 previous APAC eyes, and 22 cataract eyes. Concentrations of four main matricellular proteins (SPARC, tenascin-C, thrombospondin-2, and osteopontin) were measured using multiplexed immunoassay kits...
March 20, 2018: Current Eye Research
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