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Keewan Kim, Jean Wactawski-Wende, Kara A Michels, Karen C Schliep, Torie C Plowden, Ellen N Chaljub, Sunni L Mumford
Although minerals are linked to several reproductive outcomes, it is unknown whether dietary minerals are associated with ovulatory function. We hypothesised that low intakes of minerals would be associated with an increased risk of anovulation. We investigated associations between dietary mineral intake and both reproductive hormones and anovulation in healthy women in the BioCycle Study, which prospectively followed up 259 regularly menstruating women aged 18-44 years who were not taking mineral supplements for two menstrual cycles...
April 20, 2018: British Journal of Nutrition
Lindsey A Sjaarda, Rose G Radin, Chandra Swanson, Daniel L Kuhr, Sunni L Mumford, Noya Galai, Robert M Silver, Jean Wactawski-Wende, Neil J Perkins, Enrique F Schisterman
BACKGROUND: Inflammation, measured by high-sensitivity C-reactive protein (hsCRP), is linked to adverse reproductive outcomes. However, prevalence and predictors of low-grade inflammation are poorly understood among reproductive age women. Therefore, the current aim was to characterize: (i) the prevalence of elevated hsCRP and (ii) whether the association of various demographic, anthropometric, life style, and metabolic characteristics with higher hsCRP varies across populations of reproductive age women with varying risk profiles for adverse reproductive outcomes...
January 2018: Paediatric and Perinatal Epidemiology
Kara A Michels, Jean Wactawski-Wende, James L Mills, Karen C Schliep, Audrey J Gaskins, Edwina H Yeung, Keewan Kim, Torie C Plowden, Lindsey A Sjaarda, Ellen N Chaljub, Sunni L Mumford
STUDY QUESTION: How are concentrations of plasma homocysteine and serum folate associated with reproductive hormones and anovulation in regularly menstruating women? SUMMARY ANSWER: Higher homocysteine was associated with sporadic anovulation and hormonal changes that may be indicative of impaired ovulatory function, but higher serum folate was associated only with higher luteal phase progesterone. WHAT IS KNOWN ALREADY: Higher folate levels as well as some variants in genes relevant to one-carbon metabolism, are associated with improved reproductive outcomes and responses to fertility treatment, but only a few small studies have explored the relationship between markers of one-carbon metabolism and menstrual cycle characteristics...
August 1, 2017: Human Reproduction
Yong-Guan Zhu, Xi-Mei Xue, Andreas Kappler, Barry P Rosen, Andrew A Meharg
The biotransformation of arsenic is highly relevant to the arsenic biogeochemical cycle. Identification of the molecular details of microbial pathways of arsenic biotransformation coupled with analyses of microbial communities by meta-omics can provide insights into detailed aspects of the complexities of this biocycle. Arsenic transformations couple to other biogeochemical cycles, and to the fate of both nutrients and other toxic environmental contaminants. Microbial redox metabolism of iron, carbon, sulfur, and nitrogen affects the redox and bioavailability of arsenic species...
July 5, 2017: Environmental Science & Technology
Ethan D Goddard-Borger, Spencer J Williams
The sulfonated carbohydrate sulfoquinovose (SQ) is produced in quantities estimated at some 10 billion tonnes annually and is thus a major participant in the global sulfur biocycle. SQ is produced by most photosynthetic organisms and incorporated into the sulfolipid sulfoquinovosyl diacylglycerol (SQDG), as well as within some archaea for incorporation into glycoprotein N-glycans. SQDG is found mainly within the thylakoid membranes of the chloroplast, where it appears to be important for membrane structure and function and for optimal activity of photosynthetic protein complexes...
February 20, 2017: Biochemical Journal
C A Siegel, K D Thompson, D Walls, J Gollins, J-F Colombel, E Louis
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
Jiaojiao Li, Shashank S Pawitwar, Barry P Rosen
Arsenic is the most pervasive environmental toxic substance. As a consequence of its ubiquity, nearly every organism has genes for resistance to inorganic arsenic. In bacteria these genes are found largely in bacterial arsenic resistance (ars) operons. Recently a parallel pathway for synthesis and degradation of methylated arsenicals has been identified. The arsM gene product encodes the ArsM (AS3MT in animals) As(iii) S-adenosylmethionine methyltransferase that methylates inorganic trivalent arsenite in three sequential steps to methylarsenite MAs(iii), dimethylarsenite (DMAs(iii) and trimethylarsenite (TMAs(iii))...
October 1, 2016: Metallomics: Integrated Biometal Science
Karen C Schliep, Enrique F Schisterman, Jean Wactawski-Wende, Neil J Perkins, Rose G Radin, Shvetha M Zarek, Emily M Mitchell, Lindsey A Sjaarda, Sunni L Mumford
BACKGROUND: Clinicians often recommend limiting caffeine intake while attempting to conceive; however, few studies have evaluated the associations between caffeine exposure and menstrual cycle function, and we are aware of no previous studies assessing biological dose via well-timed serum measurements. OBJECTIVES: We assessed the relation between caffeine and its metabolites and reproductive hormones in a healthy premenopausal cohort and evaluated potential effect modification by race...
July 2016: American Journal of Clinical Nutrition
Kristen A Johnson, Lindsey A Sjaarda, Sunni L Mumford, Rebecca A Garbose, Karen C Schliep, Donald Mattison, Neil J Perkins, Jean Wactawski-Wende, Enrique F Schisterman
PURPOSE: The purpose of this study is to characterize the patterns of medication intake in healthy, reproductive-age women not using hormonal contraception. METHODS: Two hundered fifty-nine healthy, premenopausal women (18-44 years of age) enrolled in the BioCycle Study (2005-2007) were followed over two menstrual cycles. Women were excluded if they were currently using oral contraceptives or other chronic medications. Over-the-counter and prescription medication use among participants was evaluated daily throughout the study via a diary assessing type of medication, dosage, units, and frequency...
June 2016: Pharmacoepidemiology and Drug Safety
Sunni L Mumford, Jorge E Chavarro, Cuilin Zhang, Neil J Perkins, Lindsey A Sjaarda, Anna Z Pollack, Karen C Schliep, Kara A Michels, Shvetha M Zarek, Torie C Plowden, Rose G Radin, Lynne C Messer, Robyn A Frankel, Jean Wactawski-Wende
BACKGROUND: Emerging evidence suggests potential links between some dietary fatty acids and improved fertility, because specific fatty acids may affect prostaglandin synthesis and steroidogenesis. OBJECTIVE: The objective of this exploratory study was to evaluate associations between total and specific types of dietary fat intake and 1) hormone concentrations and 2) the risk of sporadic anovulation in a cohort of 259 regularly menstruating women in the BioCycle Study...
March 2016: American Journal of Clinical Nutrition
Sunni L Mumford, Richard W Browne, Karen C Schliep, Jonathan Schmelzer, Torie C Plowden, Kara A Michels, Lindsey A Sjaarda, Shvetha M Zarek, Neil J Perkins, Lynne C Messer, Rose G Radin, Jean Wactawski-Wende, Enrique F Schisterman
BACKGROUND: Evidence is growing that the equilibrium between reactive oxygen species and antioxidants plays a vital role in women's reproductive health. OBJECTIVE: The objective of this study was to evaluate variations in serum antioxidant concentrations across the menstrual cycle and associations between antioxidants and reproductive hormones and anovulation among healthy women. METHODS: The BioCycle Study, a prospective cohort, followed 259 women aged 18-44 y for up to 2 menstrual cycles...
January 2016: Journal of Nutrition
Mary A Andrews, Karen C Schliep, Jean Wactawski-Wende, Joseph B Stanford, Shvetha M Zarek, Rose G Radin, Lindsey A Sjaarda, Neil J Perkins, Robyn A Kalwerisky, Ahmad O Hammoud, Sunni L Mumford
STUDY QUESTION: Are prospectively assessed dietary factors, including overall diet quality, macronutrients and micronutrients, associated with luteal phase deficiency (LPD) in healthy reproductive aged women with regular menstrual cycles? SUMMARY ANSWER: Mediterranean Diet Score (MDS), fiber and isoflavone intake were positively associated with LPD while selenium was negatively associated with LPD after adjusting for age, percentage body fat and total energy intake...
August 2015: Human Reproduction
Shashank S Pawitwar, Sagar M Utturkar, Steven D Brown, Masafumi Yoshinaga, Barry P Rosen
To elucidate the environmental organoarsenical biocycle, we isolated a soil organism, Burkholderia sp. MR1, which reduces relatively nontoxic pentavalent methylarsenate to the more toxic trivalent methylarsenite, with the goal of identifying the gene for the reductase. Here, we report the draft genome sequence of Burkholderia sp. MR1.
2015: Genome Announcements
Anna M Gorczyca, Lindsey A Sjaarda, Emily M Mitchell, Neil J Perkins, Karen C Schliep, Jean Wactawski-Wende, Sunni L Mumford
PURPOSE: It is thought that total energy intake in women is increased during the luteal versus follicular phase of the menstrual cycle; however, less is understood regarding changes in diet composition (i.e., macro- and micronutrient intakes) across the cycle. The aim of this study was to investigate changes in macronutrient, micronutrient, and food group intakes across phases of the menstrual cycle among healthy women, and to assess whether these patterns differ by ovulatory status. METHODS: The BioCycle study (2005-2007) was a prospective cohort study of 259 healthy regularly menstruating women age 18-44 who were followed for up to two menstrual cycles...
April 2016: European Journal of Nutrition
R A Matyas, S L Mumford, K C Schliep, K A Ahrens, L A Sjaarda, N J Perkins, A C Filiberto, D Mattison, S M Zarek, J Wactawski-Wende, E F Schisterman
STUDY QUESTION: Does use of commonly used over-the-counter (OTC) pain medication affect reproductive hormones and ovulatory function in premenopausal women? SUMMARY ANSWER: Few associations were found between analgesic medication use and reproductive hormones, but use during the follicular phase was associated with decreased odds of sporadic anovulation after adjusting for potential confounders. WHAT IS KNOWN ALREADY: Analgesic medications are the most commonly used OTC drugs among women, but their potential effects on reproductive function are unclear...
July 2015: Human Reproduction
Emily M Mitchell, Robert H Lyles, Amita K Manatunga, Neil J Perkins, Enrique F Schisterman
The potential for research involving biospecimens can be hindered by the prohibitive cost of performing laboratory assays on individual samples. To mitigate this cost, strategies such as randomly selecting a portion of specimens for analysis or randomly pooling specimens prior to performing laboratory assays may be employed. These techniques, while effective in reducing cost, are often accompanied by a considerable loss of statistical efficiency. We propose a novel pooling strategy based on the k-means clustering algorithm to reduce laboratory costs while maintaining a high level of statistical efficiency when predictor variables are measured on all subjects, but the outcome of interest is assessed in pools...
December 10, 2014: Statistics in Medicine
Ankita Prasad, Sunni L Mumford, Germaine M Buck Louis, Katherine A Ahrens, Lindsey A Sjaarda, Karen C Schliep, Neil J Perkins, Kerri A Kissell, Jean Wactawski-Wende, Enrique F Schisterman
We investigated whether sexual activity was associated with reproductive function in the BioCycle Study, a prospective cohort study that followed 259 regularly menstruating women aged 18 to 44years for one (n=9) or two (n=250) menstrual cycles in 2005-2007. Women were not attempting pregnancy nor using hormonal contraceptives. History of ever having been sexually active was assessed at baseline and frequency of sexual activity, defined as vaginal-penile intercourse, was self-reported daily throughout the study...
July 2014: Hormones and Behavior
Katherine A Ahrens, Catherine J Vladutiu, Sunni L Mumford, Karen C Schliep, Neil J Perkins, Jean Wactawski-Wende, Enrique F Schisterman
PURPOSE: To evaluate the association between physical activity (PA) across the menstrual cycle and reproductive function. METHODS: The BioCycle Study (2005-2007) followed 259 healthy premenopausal women not using hormonal contraceptives for up to two menstrual cycles (N = 509 cycles). Serum leptin, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and testosterone were measured five to eight times per cycle. Linear mixed models were used to estimate the effect of past-week PA (measured four times during each cycle) on hormone levels...
February 2014: Annals of Epidemiology
Katherine Ahrens, Sunni L Mumford, Karen C Schliep, Kerri A Kissell, Neil J Perkins, Jean Wactawski-Wende, Enrique F Schisterman
OBJECTIVE: The purpose of this study was to investigate the role of leptin on reproductive hormones and ovulation. STUDY DESIGN: The BioCycle Study (2005-2007) followed 259 healthy premenopausal women not using hormonal contraceptives for ≤2 menstrual cycles (n = 509 cycles). Serum leptin, estradiol, progesterone, luteinizing hormone (LH), follicle-stimulating hormone, and testosterone were measured ≤8 times per cycle. The association of time-varying leptin and reproductive hormones over the cycle was estimated with the use of linear mixed models that were adjusted for percent body fat and age with inverse probability weighting for time-varying physical activity, caloric intake, and other reproductive hormones...
March 2014: American Journal of Obstetrics and Gynecology
Stacy A Blondin, Edwina H Yeung, Sunni L Mumford, Cuilin Zhang, Richard W Browne, Jean Wactawski-Wende, Enrique F Schisterman
OBJECTIVE: The aim of this study was to investigate how serum retinol and carotenoids (β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene) are associated with biomarkers of insulin resistance. RESEARCH METHODS AND PROCEDURES: The BioCycle Study (2005-2007) is a prospective cohort of 259 healthy premenopausal women. Fasting serum samples were collected at up to sixteen clinic visits, from which retinol, carotenoids, insulin, glucose, and sex hormone-binding globulin (SHBG) were measured...
January 1, 2013: ISRN Nutrition
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