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https://www.readbyqxmd.com/read/29237763/bisphenol-a-phthalate-metabolites-and-glucose-homeostasis-in-healthy-normal-weight-children
#1
Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen, Anders Juul
INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of The COPENHAGEN Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dualenergy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry, and fasting blood samples...
December 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29234359/subtle-inflammation-a-possible-mechanism-of-future-cardiovascular-risk-in-obese-children
#2
Watchareewan Sontichai, Prapai Dejkhamron, Peraphan Pothacharoen, Prachya Kongtaweelert, Kevalee Unachak, Nuthapong Ukarapol
Purpose: The risk of cardiovascular disease (CVD) has been shown to be associated with systemic inflammation in obese adults with metabolic syndrome (MetS). The aims of this study were to evaluate the prevalence of MetS and its relation to inflammatory markers in obese Thai children. Methods: A cross-sectional study was conducted. Children with history of endogenous obesity, chronic diseases, drug ingestion, and any acute illness within 2 weeks prior to enrollment were excluded...
November 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29218646/cardiovascular-and-metabolic-complications-diagnosis-and-management-in-obese-children
#3
REVIEW
Naval K Vikram
The world at present is facing a burden of rising prevalence of obesity in children and adolescents. The developing countries are particularly facing the dual burden on under-nutrition and obesity. This is associated with appearance and clustering of cardiometabolic abnormalities at an early age with development of chronic complications early and possible decrease in life span of these children and adolescents. In adults this clustering has been termed as 'metabolic syndrome' with definitions that can be used universally...
December 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29214673/assessing-truncal-obesity-in-predicting-cardiometabolic-risk-in-children-clinical-measures-versus-dual-energy-x-ray-absorptiometry
#4
Vincent J Palmieri, Melissa H Henshaw, Janet Carter, Shahryar M Chowdhury
AIM: The objectives of this study were to: 1) Compare the accuracy of waist:hip ratio (WHR) and waist:height ratio (WHtR) by determining their association with reference-standard measures derived from dual-energy X-ray absorptiometry (DXA) and 2) assess the relationship of DXA, WHR, and WHtR to measures of dyslipidemia, insulin resistance, and inflammation in children. METHODS: Subjects aged four to 21 were prospectively recruited. Truncal obesity by DXA was defined as the trunk fat:height ratio and trunk fat:non-trunk fat ratio...
December 7, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29207397/relationship-of-serum-fetuin-a-with-metabolic-and-clinical-parameters-in-german-children-and-adolescents-with-type-1-diabetes
#5
Christina Reinauer, Thomas Reinehr, Christina Baechle, Beate Karges, Julia Seyfarth, Katharina Foertsch, Martin Schebek, Joachim Woelfle, Michael Roden, Reinhard W Holl, Joachim Rosenbauer, Thomas Meissner
BACKGROUND AND AIM: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. METHODS: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Pa-tienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D...
December 5, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29198767/ultrasonographic-quantitative-analysis-of-fatty-pancreas-in-obese-children-its-correlation-with-metabolic-syndrome-and-homeostasis-model-assessment-of-insulin-resistance
#6
Doo Ri Kim, Mu Sook Lee, Jeong Sub Lee, Guk Myung Choi, Ki Soo Kang
OBJECTIVES: To evaluate pancreatic echogenicity on transabdominal ultrasonography and the correlation of fatty pancreas with metabolic syndrome (MetS), as well as insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]). STUDY DESIGN: This retrospective study included 135 obese children and adolescents who underwent transabdominal ultrasonography from January 2015 to December 2015. Fatty pancreas was quantitatively analyzed using the pancreato-perihepatic fat index (PPHFI)...
November 29, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29176029/serum-progranulin-levels-in-relation-to-insulin-resistance-in-childhood-obesity
#7
Eman M Alissa, Rima H Sutaih, Hayat Z Kamfar, Abdulmoeen E Alagha, Zuhair M Marzouki
BACKGROUND: Progranulin is an adipokine that is involved in the inflammatory response, glucose metabolism, insulin resistance, and may therefore be involved in chronic subclinical inflammation associated with the pathogenesis of childhood obesity. We aimed to investigate the association of circulating progranulin levels with metabolic parameters in children and to assess the importance of progranulin as a biomarker for metabolic diseases. METHODS: A total of 150 children were consecutively recruited from the Pediatric Nutrition Clinics at King Abdulaziz University Hospital in Jeddah, Saudi Arabia...
November 25, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29159854/the-effect-of-impaired-glucose-metabolism-on-weight-loss-in-multidisciplinary-childhood-obesity-treatment
#8
Julie T Kloppenborg, Michael Gamborg, Cilius E Fonvig, Tenna R H Nielsen, Oluf Pedersen, Jesper Johannesen, Torben Hansen, Jens-Christian Holm
OBJECTIVE: To investigate whether children and adolescents exhibiting an impaired glucose metabolism are more obese at treatment entry and less likely to reduce their degree of obesity during treatment. METHODS: The present study is a longitudinal observational study, including children and adolescents from the Children's Obesity Clinic, Holbaek, Denmark. Anthropometrics, pubertal development, socioeconomic status (SES), and fasting concentrations of plasma glucose, serum insulin, serum C-peptide, and whole blood glycosylated hemoglobin (HbA1c) were collected at treatment entry and at follow-up...
November 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29108814/waist-to-height-ratio-and-sedentary-lifestyle-as-predictors-of-metabolic-syndrome-in-children-in-ecuador
#9
F Aguirre P, A Coca, M F Aguirre, G Celis
OBJECTIVE: To determine the predictors and prevalence of metabolic syndrome (MS) and the presence of vascular inflammation in apparently-normal children (10-15 years) of both sexes in Guayaquil, Ecuador. STUDY DESIGN AND METHODS: We included 395 apparently-healthy students from a middle-income school in a cross-sectional survey. Informed consent was obtained from students and parents. Anthropometric measurements including blood pressure (BP), body mass index (BMI) and waist-to-height ratio (WHtR), and blood tests were recorded...
November 3, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/29099463/associations-of-insulin-resistance-and-glycemia-with-liver-enzymes-in-hispanic-latino-youths-results-from-the-hispanic-community-children-s-health-study-study-of-latino-youth-sol-youth
#10
Christina M Parrinello, Bryan J Rudolph, Mariana Lazo, Linda C Gallo, Bharat Thyagarajan, Scott J Cotler, Qibin Qi, Tossaporn Seeherunvong, Denise C Vidot, Howard D Strickler, Robert C Kaplan, Carmen R Isasi
BACKGROUND: Associations of insulin resistance and hyperglycemia with a panel of liver enzymes have not been well studied in a young, heterogenous Hispanic/Latino population. We aimed to assess the associations of insulin resistance and glycemia with nonalcoholic fatty liver disease (NAFLD), as measured by liver enzymes and the pediatric NAFLD fibrosis index (PNFI), and whether these associations are modified by body mass index and mediated by inflammation or endothelial dysfunction. MATERIALS AND METHODS: We conducted a cross-sectional study of 1317 boys and girls aged 8 to 16 years from the Hispanic Community Children's Health Study/Study of Latino Youth...
November 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29095002/-physical-fitness-and-insulin-sensitivity-in-a-group-of-obese-children-from-8-to-13-years-of-age-by-puberal-state
#11
Fabián Vasquez, Erik Diaz, Lydia Lera, Jorge Meza, Katherine Curi, Jorge Torres, Raquel Burrows
INTRODUCTION: Insulin resistance is the most common metabolic disorder associated with obesity and highest cardiometabolic risk in children. If the inadequate physical condition is added, they have a high risk of developing cardiometabolic complications at an early age. OBJECTIVE: To evaluate physical fitness and insulin sensitivity in obese school children of 8-13 years of age from three public schools in the Metropolitan Region of Santiago. METHODS: the study was carried out in 61 obese school children (25 Tanner I-II y 36 Tanner III-V)...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29073286/differential-adipokine-receptor-expression-on-circulating-leukocyte-subsets-in-lean-and-obese-children
#12
Genoveva Keustermans, Laila B van der Heijden, Berlinda Boer, Rianne Scholman, Roos Nuboer, Gerard Pasterkamp, Berent Prakken, Wilco de Jager, Eric Kalkhoven, Arieke J Janse, Henk S Schipper
BACKGROUND: Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far...
2017: PloS One
https://www.readbyqxmd.com/read/29064478/dna-methylation-in-blood-from-neonatal-screening-cards-and-the-association-with-bmi-and-insulin-sensitivity-in-early-childhood
#13
S J van Dijk, T J Peters, M Buckley, J Zhou, P A Jones, R A Gibson, M Makrides, B S Muhlhausler, P L Molloy
BACKGROUND/OBJECTIVES: There is increasing evidence that metabolic diseases originate in early life, and epigenetic changes have been implicated as key drivers of this early life programming. This led to the hypothesis that epigenetic marks present at birth may predict an individual's future risk of obesity and type 2 diabetes. In this study, we assessed whether epigenetic marks in blood of newborn children were associated with body mass index (BMI) and insulin sensitivity later in childhood...
September 25, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29025201/the-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-in-overweight-korean-children-and-adolescents
#14
Dong-Yoon Yoo, Yu Sun Kang, Eun Byul Kwon, Eun-Gyong Yoo
PURPOSE: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents. METHODS: Data from 255 overweight (aged 8...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28991837/serum-osteocalcin-levels-in-children-with-nonalcoholic-fatty-liver-disease
#15
Saleh Amin, Doaa El Amrousy, Shaymaa Elrifaey, Rasha Gamal, Hossam Hodeib
OBJECTIVES: to investigate the relationship between osteocalcin and non alcoholic fatty liver disease (NAFLD) in obese children. METHOD: 60 obese children with NAFLD were taken as patient group and 60 non - NAFLD children with matches age, sex and BMI were taken as control group. Anthropometric measurements, abdominal ultrasonography for diagnosis and grading of NAFLD, and laboratory investigations in the form of liver function tests, lipid profile, fasting serum glucose and insulin, and serum osteocalcin levels were done for all children...
October 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28913977/the-effect-of-diet-or-exercise-on-ectopic-adiposity-in-children-and-adolescents-with-obesity-a-systematic-review-and-meta-analysis
#16
REVIEW
W Hens, D Vissers, D Hansen, S Peeters, J Gielen, L Van Gaal, J Taeymans
OBJECTIVE: Ectopic fat depostion in youth with obesity is associated with an increased cardiovascular disease risk. The aim of this meta-analysis was to summarize the evidence for the use of diet and/or exercise on ectopic adiposity in this population. METHODS: A systematic literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Clinical trials that assessed ectopic fat deposition and included study arms with diet and/or exercise were searched in PubMed, PEDro and the Cochrane database...
November 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28899517/metabolic-biomarkers-in-community-obese-children-effect-of%C3%A2-obstructive-sleep-apnea-and-its-treatment
#17
María Luz Alonso-Álvarez, Joaquin Terán-Santos, Mónica Gonzalez Martinez, José Aurelio Cordero-Guevara, María José Jurado-Luque, Jaime Corral-Peñafiel, Joaquin Duran-Cantolla, Estrella Ordax Carbajo, Fernando MasaJimenez, Leila Kheirandish-Gozal, David Gozal
OBJECTIVE: Obesity and obstructive sleep apnea in children have been associated with metabolic morbidities. The present study aimed to evaluate the presence of metabolic alterations among obese children recruited from the community, with and without obstructive sleep apnea syndrome (OSAS), and the impact of treatment of OSAS on metabolic profiles. METHODS: A cross-sectional, prospective, multicenter study of Spanish children aged 3-14 years with a body mass index (BMI) ≥95th percentile for age and sex were randomly selected in the first phase...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28898874/associations-between-liver-enzyme-levels-and-parameters-of-the-metabolic-syndrome-in-obese-children
#18
Christiane S Hampe, Michele L Shaffer, Christian L Roth
BACKGROUND: Obesity is strongly associated with insulin resistance, hypertension, dyslipidemia, and therefore risk for metabolic syndrome (MetS), which is an increasing problem in youth. The potential role of elevated liver enzyme levels in this context needs to be further investigated. METHODS: This paper provides a post hoc analysis of a cross-sectional study of 77 obese nondiabetic children (51% female; median age 11.7 years; BMI >97th percentile) enrolled at the University of Bonn, Bonn, Germany...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28776381/insulin-resistance-and-the-metabolic-syndrome-are-related-to-the-severity-of-steatosis-in-the-pediatric-population-with-obesity
#19
Esther Ubiña-Aznar, Leopoldo Tapia-Ceballos, José Miguel Rosales-Zabal, Rocío Porcel-Chacón, Francisco Poveda-Gómez, Carmen Lozano-Calero, Carmen Ortiz-Cuevas, Francisco Rivas-Ruiz, Andrés Sánchez Cantos, José María Navarro Jarabo
BACKGROUND: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. METHODS: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. RESULTS: A total of 94 children (51 males) aged from six to 14 years were included...
November 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28771179/leptin-receptor-gene-variant-rs11804091-is-associated-with-bmi-and-insulin-resistance-in-spanish-female-obese-children-a-case-control-study
#20
Josune Olza, Azahara I Rupérez, Mercedes Gil-Campos, Rosaura Leis, Ramón Cañete, Rafael Tojo, Ángel Gil, Concepción M Aguilera
Leptin is an endocrine hormone that has a critical role in body weight homoeostasis and mediates its effects via the leptin receptor (LEPR). Common polymorphisms in the genes coding leptin receptors have been associated with metabolic abnormalities. We assessed the association of 28 LEPR polymorphisms with body mass index (BMI) and their relationship with obesity-related phenotypes, inflammation and cardiovascular disease risk biomarkers. A multicentre case-control study was conducted in 522 children (286 with obesity and 236 with normal-BMI)...
August 3, 2017: International Journal of Molecular Sciences
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