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https://www.readbyqxmd.com/read/29649377/vitamin-d-status-and-cardiovascular-risk-in-obesity-effect-of-physical-activity-in-nonvitamin-d-supplemented-adolescents
#1
Md Jobayer Hossain, Alexa Levinson, Donald George, Jose Canas, Seema Kumar, P Babu Balagopal
BACKGROUND: The relationship among inadequate vitamin D status, obesity, and cardiometabolic risk and the potential impact of physical activity-based interventions on vitamin D status are poorly characterized in children. This study aimed to address these issues. METHODS: We studied a total of 21 adolescents (15 obese and 6 normal weight; age: 14-18 years; Tanner stage>IV). Adolescents with obesity (n = 15) underwent a randomized controlled (8 in the intervention group and 7 in the control group) 3-month physical activity-based lifestyle intervention...
March 13, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29617475/ultrasonographic-markers-of-cardiovascular-disease-risk-in-obese-children
#2
Karla Cristina Malta Costa, Luiz Antonio Del Ciampo, Patrícia Silveira Silva, Jailson Costa Lima, Wellington de Paula Martins, Carlos Alberto Nogueira-de-Almeida
OBJECTIVE: To evaluate whether the obesity alters ultrasonographical markers of metabolic and cardiovascular disease risk in children. METHODS: A cross-sectional study evaluated 80 children aged between 6 and 10 years, comparing 40 obese with 40 normal children. The following parameters were assessed: weight; height; body mass index; arterial blood pressure; body fat; basal metabolic rate; HDL-cholesterol, LDL-cholesterol and total cholesterol; fasting insulin and glucose; quantitative insulin sensitivity check index (QUICKI); homeostasis model of assessment - insulin resistance (HOMA-IR); basal diameter of the brachial artery; brachial artery flow mediated dilation (FMD) and of pulsatility index change (PI-C)...
March 29, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29565153/inflammatory-cytokines-and-non-alcoholic-fatty-liver-disease-nafld-in-obese-children-and-adolescents
#3
Silvana Neves Ferraz de Assunção, Ney Christian Amaral Boa Sorte, Crésio De Aragão Dantas Alves, Patrícia S Almeida Mendes, Carlos Roberto Brites Alves, Luciana Rodrigues Silva
INTRODUCTION: Non-alcoholic fatty liver disease is characterized by the intrahepatic deposition of fat. It is the most prevalent liver disease in the world, affecting obese children and adolescents. Its pathophysiology is not fully understood, although it is often related to insulin resistance. This in turn would be due to an inflammatory condition common to obesity. Thus, the objective of this study was to describe the behavior of proinflammatory cytokines in obese children and adolescents, with and without non-alcoholic fatty liver disease...
January 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29565148/physical-fitness-cardiometabolic-risk-and-heart-rate-recovery-in-chilean-children
#4
María José Arias Téllez, Johana Patricia Soto-Sánchez, Sergio Gerardo Weisstaub
OBJECTIVE: To evaluate the association of physical fitness (PF) and cardiometabolic risk (CMR) with heart rate recovery time (ΔHRR) in Chilean school aged children. METHODS: Cross-sectional study in 478 6-9 years old children participants. We measured weight, height and abdominal circumference. Fitness was measured using the 6MWT, grip strength and leap forward without impulse tests; PF z-scores were calculated. Heart rate (HR) was monitored and recorded during the 6MWT...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29523875/insulin-sensitivity-is-reduced-in-children-with-high-body-fat-regardless-of-bmi
#5
Timothy J Fairchild, Heidi Klakk, Malene Heidemann, Anders Grøntved, Niels Wedderkopp
PURPOSE: To examine the association between insulin sensitivity and adiposity in children stratified according to their body mass index (BMI: normal weight, NW; overweight or obese, OW/OB) and body-fat percentage (BF%: adipose or NonAdipose), and determine whether cardiorespiratory fitness (CRF) ameliorates any deleterious associations. METHODS: This prospective cohort study comprises a cross-sectional and longitudinal analyses of data collected at baseline and 2 years later on children (7...
February 23, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29505614/high-normal-estimated-glomerular-filtration-rate-and-hyperuricemia-positively-correlate-with-metabolic-impairment-in-pediatric-obese-patients
#6
Roberta Ricotti, Giulia Genoni, Enza Giglione, Alice Monzani, Martina Nugnes, Sara Zanetta, Matteo Castagno, Agostina Marolda, Giorgio Bellomo, Gianni Bona, Simonetta Bellone, Flavia Prodam
BACKGROUND: Childhood obesity represents a major health concern worldwide due to its well established detrimental effect on cardiovascular and its potential negative effect on kidney functions. However, biomarkers that can help diagnose early stages of kidney damage in obese children represent an unmet clinical need. OBJECTIVES: In this study, we asked whether the prevalence of microalbuminuria, estimated glomerular filtration rate (eGFR) or hyperuricemia recorded in a wide cohort of obese children and adolescents would positively correlate with cardiometabolic dysfunction in these subjects...
2018: PloS One
https://www.readbyqxmd.com/read/29493116/serum-igfbp-2-levels-are-associated-with-reduced-insulin-sensitivity-in-obese-children
#7
S W Yau, B E Harcourt, K-T Kao, E J Alexander, V C Russo, G A Werther, M A Sabin
Insulin-like growth factor binding protein 2 (IGFBP-2) may represent a critical link between body composition and insulin sensitivity. We investigated the relationship between circulating IGFBP-2 levels, body composition, insulin sensitivity, energy intake and physical activity in children with obesity. Children were recruited via the Weight Management Service at the Royal Children's Hospital, Melbourne, as part of the Childhood Overweight BioRepository of Australia (COBRA). Comprehensive anthropometric, biochemical and environmental data were collected and compared to serum IGFBP-2 levels (measured by enzyme-linked immunosorbent assay)...
February 28, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29485130/the-rs626283-variant-in-the-mboat7-gene-is-associated-with-insulin-resistance-and-fatty-liver-in-caucasian-obese-youth
#8
Giuseppina R Umano, Sonia Caprio, Anna Di Sessa, Naga Chalasani, Daniel J Dykas, Bridget Pierpont, Allen E Bale, Nicola Santoro
OBJECTIVES: Non alcoholic fatty liver disease (NAFLD) is a leading cause of liver damage in childhood, its occurrence is influenced by genetic and environmental factors. Recently, the rs626283 polymorphism in the MBOAT7 gene has been found to be associated with alcoholic liver disease and NAFLD in adults. METHODS: In a multiethnic cohort of obese children and adolescents we genotyped the rs626283 polymorphism in the MBOAT7 gene, evaluated insulin sensitivity by an oral glucose tolerance test, and measured the intra-hepatic fat content (HFF%) by magnetic resonance imaging...
February 27, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29411326/plasma-adrenomedullin-level-in-children-with-obesity-relationship-to-left-ventricular-function
#9
Kotb Abbass Metwalley, Hekma Saad Farghaly, Tahra Sherief
BACKGROUND: Obese children are at increased risk for abnormal cardiac structure and function. Little is known about adrenomedullin (AM), a cytokine produced in various organs and tissues, as a biomarker of cardiac hypertrophy in obese children. This study aimed to assess the plasma AM levels in a cohort of obese children and its relationship to left ventricular (LV) functions. METHODS: The study included 60 obese children and 60 non-obese children matched for age and gender as control group...
February 6, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29390101/breastfeeding-and-maternal-hypertension
#10
Sangshin Park, Nam-Kyong Choi
BACKGROUND: Little is known about the relationship between breastfeeding and hypertension. We performed this study to identify whether breastfeeding itself influenced maternal hypertension and whether degree of obesity or insulin sensitivity would contribute to the relationship between breastfeeding and hypertension in postmenopausal women. METHODS: Our study population comprised 3,119 nonsmoking postmenopausal women aged 50 years or above in the 2010-2011 Korea National Health and Nutrition Examination Survey...
January 25, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29381651/exercise-effects-on-adipose-tissue-postprandial-lipolysis-and-blood-flow-in-children
#11
Huimin Yan, Joseph R Pierce, Kimberly B Myers, Katrina D DuBose, Gabriel S Dubis, Charles J Tanner, Robert C Hickner
Poor suppression of lipolysis and blunted increase in blood flow following meal ingestion in obese adults may indicate resistance to the antilipolytic action of insulin. Exercise may be used to normalize lipolytic responses to food intake by increasing insulin sensitivity. PURPOSE: To determine if acute bouts of aerobic exercise and/or excise training alter lipolytic and blood flow responses to food intake in lean (LN) and obese (OB) children. METHODS: Sixty-five children (9-11 yrs) were randomized into acute exercise (EX: 16 LN and 28 OB) or control (CON: 9 LN and 12 OB) groups that exercised (EX), or rested (CON) between standardized breakfast and lunch...
January 30, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29357498/validity-and-reliability-of-a-novel-metabolic-flexibility-test-in-children-with-obesity
#12
Lisa Chu, Katherine M Morrison, Michael C Riddell, Sandeep Raha, Brian W Timmons
PURPOSE: Existing methods for diagnosing diabetes and for identifying risk of diabetes development are completed under resting conditions and based on adult data. Studying additional methods to identify metabolic risk in children is warranted. Our objective was to examine the validity and reliability of a metabolic flexibility (MetFlex) test for screening glycemia and insulin resistance (IR) in children. We hypothesized higher MetFlex during exercise would be correlated with lower fasting glucose and homeostasis model assessment of insulin resistance (HOMA-IR), and higher whole body insulin sensitivity index (WBISI) and insulin secretion-sensitivity index-2 (ISSI-2)...
December 21, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29319392/the-association-between-serum-vaspin-and-omentin-1-levels-in-obese-children-with-metabolic-syndrome
#13
Muammer Buyukinan, Muge Atar, Ummugulsum Can, Ozgur Pirgon, Asuman Guzelant, Isa Deniz
BACKGROUND AND AIM: Excess visceral fat accumulation results in altered release of adipokines. The aim of this study was to examine the relationship between new adipokines (omentin-1 and vaspin), insulin resistance, and serum inflammatory markers in obese subjects with metabolic syndrome (MS). PATIENTS AND METHODS: The study included a total of 121 obese children (79 females and 42 males, aged 12-17 years old). The obese subjects were divided into two groups based on the presence or absence of MS criteria (MS group and non-MS group)...
March 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29285449/carotid-intima-medial-thickness-and-glucose-homeostasis-in-indian-obese-children-and-adolescents
#14
Aashima Dabas, Thushanth Thomas, Monita Gahlot, Nandita Gupta, K Devasenathipathy, Rajesh Khadgawat
Objective: To evaluate for subclinical atherosclerosis and its risk factors in Indian obese children. Materials and Methods: A cross-sectional, case-control study was conducted to recruit 80 children aged 6-17 years with constitutional obesity as cases and 23 age- and gender-matched controls with normal body mass index (BMI). Anthropometric and clinical evaluation was followed by biochemical analysis and body fat estimation by dual-energy X-ray absorptiometry in cases...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29242622/assessment-of-disturbed-glucose-metabolism-and-surrogate-measures-of-insulin-sensitivity-in-obese-children-and-adolescents
#15
Christian L Roth, Clinton Elfers, Christiane S Hampe
BACKGROUND: With the rising prevalence of obesity and type 2 diabetes (T2D) in obese children, it is becoming imperative to detect disturbed glucose metabolism as early as possible in order to prevent T2D development. SUBJECTS/METHODS: Cross-sectional study of 92 obese children (median age 11.7 years, 51% female) and 7 lean children (median age 11.4 years, 57% female) who underwent an oral glucose tolerance test (OGTT) in a tertiary pediatric care center. Glucose tolerance was assessed and different indices for β-cell function, insulin sensitivity and insulin secretion were calculated...
December 14, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29237763/bisphenol-a-phthalate-metabolites-and-glucose-homeostasis-in-healthy-normal-weight-children
#16
Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen, Anders Juul
INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of the Copenhagen Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dual-energy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry and fasting blood samples...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29234359/subtle-inflammation-a-possible-mechanism-of-future-cardiovascular-risk-in-obese-children
#17
Watchareewan Sontichai, Prapai Dejkhamron, Peraphan Pothacharoen, Prachya Kongtaweelert, Kevalee Unachak, Nuthapong Ukarapol
Purpose: The risk of cardiovascular disease (CVD) has been shown to be associated with systemic inflammation in obese adults with metabolic syndrome (MetS). The aims of this study were to evaluate the prevalence of MetS and its relation to inflammatory markers in obese Thai children. Methods: A cross-sectional study was conducted. Children with history of endogenous obesity, chronic diseases, drug ingestion, and any acute illness within 2 weeks prior to enrollment were excluded...
November 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29218646/cardiovascular-and-metabolic-complications-diagnosis-and-management-in-obese-children
#18
REVIEW
Naval K Vikram
The world at present is facing a burden of rising prevalence of obesity in children and adolescents. The developing countries are particularly facing the dual burden on under-nutrition and obesity. This is associated with appearance and clustering of cardiometabolic abnormalities at an early age with development of chronic complications early and possible decrease in life span of these children and adolescents. In adults this clustering has been termed as 'metabolic syndrome' with definitions that can be used universally...
December 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29214673/assessing-truncal-obesity-in-predicting-cardiometabolic-risk-in-children-clinical-measures-versus-dual-energy-x-ray-absorptiometry
#19
Vincent J Palmieri, Melissa H Henshaw, Janet Carter, Shahryar M Chowdhury
AIM: The objectives of this study were to 1) compare the accuracy of waist:hip ratio (WHR) and waist:height ratio (WHtR) by determining their association with reference-standard measures derived from dual-energy X-ray absorptiometry (DXA) and 2) assess the relationship of DXA, WHR and WHtR to measures of dyslipidemia, insulin resistance and inflammation in children. METHODS: Subjects aged four to 21 were prospectively recruited. Truncal obesity by DXA was defined as the trunk fat:height ratio and trunk fat:nontrunk fat ratio...
December 7, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29207397/relationship-of-serum-fetuin-a-with-metabolic-and-clinical-parameters-in-german-children-and-adolescents-with-type-1-diabetes
#20
Christina Reinauer, Thomas Reinehr, Christina Baechle, Beate Karges, Julia Seyfarth, Katharina Foertsch, Martin Schebek, Joachim Woelfle, Michael Roden, Reinhard W Holl, Joachim Rosenbauer, Thomas Meissner
BACKGROUND AND AIM: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. METHODS: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Pa-tienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D...
2018: Hormone Research in Pædiatrics
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