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Magnesium AND pancreatic cancer

Mahdi Shiri, Mona Navaei-Nigjeh, Maryam Baeeri, Mahban Rahimifard, Hossein Mahboudi, Ahmad Reza Shahverdi, Abbas Kebriaeezadeh, Mohammad Abdollahi
Diazinon (DZ) is an organophosphorus insecticide that acts as an acetylcholinesterase inhibitor. It is important to note that it can induce oxidative stress, lipid peroxidation, diabetic disorders, and cytotoxicity. Magnesium oxide (MgO) and selenium nanoparticles (Se NPs) showed promising protection against oxidative stress, lipid peroxidation, cytotoxicity, and diabetic disorders. Therefore, this study was conducted to explore the possible protective mechanisms of MgO and Se NPs against DZ-induced cytotoxicity in PaTu cell line...
2016: International Journal of Nanomedicine
Mochamat, Henning Cuhls, Milka Marinova, Stein Kaasa, Christiane Stieber, Rupert Conrad, Lukas Radbruch, Martin Mücke
We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO,, and a selection of cancer journals have been searched up until 15 April 2016. The systematic literature research yielded 4214 publications with 21 of these included in the final evaluation. Regarding minerals, our search identified only one study examining the use of magnesium with no effect on weight loss...
February 2017: Journal of Cachexia, Sarcopenia and Muscle
Mathieu Gautier, Marianne Perrière, Michael Monet, Alison Vanlaeys, Irina Korichneva, Isabelle Dhennin-Duthille, Halima Ouadid-Ahidouch
Transient Receptor Potential Melastatin-related 7 (TRPM7) is a non-selective cation channel fused with a functional kinase domain. Physiologically, TRPM7 channel is involved in magnesium homeostasis, cell survival and gastrulation. The channel part is responsible for calcium, magnesium, and metal trace entries. Cation current through TRPM7 channel is inhibited by both intracellular magnesium and magnesium complexed with nucleotides. In parallel, the kinase is able to phosphorylate cytoskeleton proteins like myosin chain regulating cell tension and motility...
2016: Current Medicinal Chemistry
A Schattner, I Dubin, R Huber, M Gelber
BACKGROUND: Hypercalcaemia of malignancy is well recognised, but hypocalcaemia in cancer patients is not, although it is increasingly encountered. METHODS: Analysis of an exemplary case and a narrative review of the literature based on the search terms cancer and hypocalcaemia. RESULTS: Hypocalcaemia may affect as many as 10% of hospitalised cancer patients. We identified 12 different potential mechanisms of hypocalcaemia of malignancy. Identifying the pathogenesis is essential for the correct treatment and can usually be performed at the bedside, based on serum parathyroid hormone (PTH) levels, creatinine, phosphate, magnesium, creatine kinase, liver enzymes and 25(OH)D...
July 2016: Netherlands Journal of Medicine
Irfan Moinuddin, Asif Bala, Butool Ali, Husna Khan, Erika Bracamonte, Amy Sussman
Acute oxalate nephropathy can occur due to primary hyperoxaluria and secondary hyperoxaluria. The primary hyperoxalurias are a group of autosomal recessive disorders of endogenous oxalate overproduction. Secondary hyperoxaluria may occur as a result of excess dietary intake, poisoning with oxalate precursors (ethylene glycol), or enteric hyperoxaluria. The differential diagnosis of enteric hyperoxaluria includes inflammatory bowel disease, short bowel syndrome, bariatric surgery (with jejunoileal bypass or Roux-en-Y gastric bypass), celiac disease, partial colectomy, and chronic pancreatitis...
February 2016: Human Pathology
Daniel Dibaba, Pengcheng Xun, Kuninobu Yokota, Emily White, Ka He
BACKGROUND: Studies document that magnesium is inversely associated with the risk of diabetes, which is a risk factor of pancreatic cancer. However, studies on the direct association of magnesium with pancreatic cancer are few and findings are inconclusive. In this study, we aimed to investigate the longitudinal association between magnesium intake and pancreatic cancer incidence in a large prospective cohort study. METHOD: A cohort of 66,806 men and women aged 50-76 years at baseline who participated in the VITamins And Lifestyle (VITAL) study was followed from 2000 to 2008...
December 1, 2015: British Journal of Cancer
Björn Lindkvist, Mary E Phillips, J Enrique Domínguez-Muñoz
Pancreatic exocrine insufficiency (PEI) frequently occurs secondary to exocrine pancreatic disease (e.g. chronic pancreatitis, cystic fibrosis, cancer) or pancreatic/gastrointestinal surgery, resulting in the maldigestion of nutrients and consequently malnutrition. Pancreatic enzyme replacement therapy (PERT) is the cornerstone of PEI management. Despite its clinical relevance, the diagnosis of PEI in clinical practice is challenging, as the current gold standard test is cumbersome, and alternatives have limited availability or accuracy...
November 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Ramasamy Venkat Ragavan, Kalavathi Murugan Kumar, Vijayaparthasarathi Vijayakumar, Sundaramoorthy Sarveswari, Sudha Ramaiah, Anand Anbarasu, Sivashanmugam Karthikeyan, Periyasamy Giridharan, Nalilu Suchetha Kumari
BACKGROUND: Pyrazolones are traditionally synthesized by the reaction of β-keto esters with hydrazine and its derivatives. There are methods to synthesize β-keto esters from esters and aldehydes, but these methods have main limitation in varying the substituents. Often, there are a number of methods such as acylation of enolates in which a chelating effect has been employed to lock the enolate anion using lithium and magnesium salts; however, these methods suffer from inconsistent yields in the case of aliphatic acylation...
July 19, 2013: Organic and Medicinal Chemistry Letters
Rick J Jansen, Dennis P Robinson, Rachael Z Stolzenberg-Solomon, William R Bamlet, Mariza de Andrade, Ann L Oberg, Kari G Rabe, Kristin E Anderson, Janet E Olson, Rashmi Sinha, Gloria M Petersen
PURPOSE: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. Our objective was to evaluate the risk of pancreatic cancer associated with nutrients found in fruits and vegetables and nutrient supplementation using a clinic-based case-control design. METHODS: Our study included 384 rapidly ascertained cases and 983 controls frequency-matched on age at time of recruitment (in 5-year increments), race, sex, and region of residence...
June 2013: Journal of Gastrointestinal Cancer
T Di Valentin, Y Alam, A Ali Alsharm, S Arif, F Aubin, J Biagi, C M Booth, S Bourque, R Burkes, P Champion, B Colwell, C Cripps, M Dallaire, M Dorreen, N Finn, D Frechette, S Gallinger, J Gapski, C Giacomantonio, S Gill, R Goel, R Goodwin, L Grimard, A Grothey, N Hammad, D Hedley, K Jhaveri, D Jonker, Y Ko, M L'espérance, J Maroun, H Ostic, N Perrin, M Rother, E St-Hilaire, M Tehfe, M Thirlwell, S Welch, N Yarom, T Asmis
The annual Eastern Canadian Colorectal Cancer Consensus Conference was held in Ottawa, Ontario, October 22-23, 2010. Health care professionals involved in the care of patients with colorectal cancer participated in presentation and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses current issues in the management of colorectal cancer, such as the use of epidermal growth factor inhibitors in metastatic colon cancer, the benefit of calcium and magnesium with oxaliplatin chemotherapy, the role of microsatellites in treatment decisions for stage II colon cancer, the staging and treatment of rectal cancer, and the management of colorectal and metastatic pancreatic cancers...
June 2012: Current Oncology
Esther Molina-Montes, Petra A Wark, María-José Sánchez, Teresa Norat, Paula Jakszyn, Leila Luján-Barroso, Dominique S Michaud, Francesca Crowe, Naomi Allen, Kay-Tee Khaw, Nicholas Wareham, Antonia Trichopoulou, George Adarakis, Helen Katarachia, Guri Skeie, Maria Henningsen, Ann Ragnhild Broderstad, Franco Berrino, Rosario Tumino, Domenico Palli, Amalia Mattiello, Paolo Vineis, Pilar Amiano, Aurelio Barricarte, José-María Huerta, Eric J Duell, José-Ramón Quirós, Weimin Ye, Malin Sund, Björn Lindkvist, Dorthe Johansen, Kim Overvad, Anne Tjønneland, Nina Roswall, Kuanrong Li, Verena A Grote, Annika Steffen, Heiner Boeing, Antoine Racine, Marie-Christine Boutron-Ruault, Franck Carbonnel, Petra H M Peeters, Peter D Siersema, Veronika Fedirko, Mazda Jenab, Elio Riboli, Bas Bueno-de-Mesquita
Several studies support a protective effect of dietary magnesium against type 2 diabetes, but a harmful effect for iron. As diabetes has been linked to pancreatic cancer, intake of these nutrients may be also associated with this cancer. We examined the association between dietary intake of magnesium, total iron and heme-iron and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In total, 142,203 men and 334,999 women, recruited between 1992 and 2000, were included...
October 1, 2012: International Journal of Cancer. Journal International du Cancer
Pierre Rybarczyk, Mathieu Gautier, Frédéric Hague, Isabelle Dhennin-Duthille, Denis Chatelain, Julie Kerr-Conte, François Pattou, Jean-Marc Regimbeau, Henri Sevestre, Halima Ouadid-Ahidouch
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of cancer with a tendency to invade surrounding healthy tissues, leading to a largely incurable disease. Despite many advances in modern medicine, there is still a lack of early biomarkers as well as efficient therapeutical strategies. The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselective cation channel that is involved in maintaining Ca(2+) and Mg(2+) homeostasis. It has been recently reported to regulate cell differentiation, proliferation and migration...
September 15, 2012: International Journal of Cancer. Journal International du Cancer
L M Krums, A I Parfenov, E A Sabel'nikova, R B Gudkova, N N Vorob'eva
In this article presented results of examination and treatment of 207 patients with glutensensitive celiac disease. And also you can find comprehensive method for the treatment of patients with varying severity of disease. The fundamental method of therapy glutensensitive celiac disease is strict lifelong adherence to a gluten-free diet (GFD), which eliminated protein cereal--gluten contained in wheat, rye and barley. Recently, there is large number of products which include the "hidden gluten". Its elimination from the diet of GFD is mandatory for patients with celiac disease...
2011: Experimental & Clinical Gastroenterology
Nelson S Yee, Weiqiang Zhou, I-Chau Liang
Genetic analysis of pancreatic development has provided new insights into the mechanisms underlying the formation of exocrine pancreatic neoplasia. Zebrafish sweetbread (swd) mutants develop hypoplastic acini and dysmorphic ducts in the exocrine pancreas, with impeded progression of cell division cycle and of epithelial growth. Positional cloning and allelic complementation have revealed that the swd mutations affect the transient receptor potential melastatin-subfamily member 7 (trpm7) gene, which encodes a divalent cation-permeable channel with kinase activity...
March 2011: Disease Models & Mechanisms
Hui-Fen Chiu, Shang-Shyue Tsai, Trong-Neng Wu, Chun-Yuh Yang
The objective of this study was to examine the relationship between total trihalomethanes (TTHM) levels in public water supplies and risk of pancreatic cancer and to determine whether calcium (Ca) and magnesium (Mg) levels in drinking water modify the effects of TTHM on risk to develop pancreatic cancer. A matched case-control study was used to investigate the relationship between the risk of death attributed to pancreatic cancer and exposure to TTHM in drinking water in 53 municipalities in Taiwan. All pancreatic cancer deaths in the 53 municipalities from 1998 through 2007 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health...
July 2010: Environmental Research
John J Grzesiak, Fabian Vargas, Michael Bouvet
OBJECTIVES: We previously showed that divalent cations regulate alpha2beta1 integrin-mediated pancreatic cancer cell interactions with type I collagen in 2 dimensions (2D), including cell adhesion, migration, and proliferation. Presently, we examined divalent cation-dependent alpha2beta1 integrin-mediated pancreatic cancer cell adhesion and proliferation on type I collagen in a novel 3D in vitro model. METHODS: Cell attachment, proliferation, and antibody inhibition assays on type I collagen in both 2D and 3D, and microscopy and immunoblotting were used for these studies...
August 2010: Pancreas
Yamini Kesavan, Edward Giovannucci, Charles S Fuchs, Dominique S Michaud
Many studies have investigated the relation between magnesium and iron intake and diabetes and, separately, between diabetes and pancreatic cancer. However, no known study has examined the direct association of magnesium and iron intake with pancreatic cancer risk. The authors obtained magnesium and iron intake data using food frequency questionnaires from the US male Health Professionals Follow-up Study, which began in 1986. During 851,476 person-years and 20 years of follow-up, 300 pancreatic cancer cases were documented...
January 15, 2010: American Journal of Epidemiology
Leon Fisher, Elizabeth Byrnes, Alexander A Fisher
Little is known about the role of fat-soluble vitamins K and D in liver function and bone metabolism in biliary and pancreatic diseases associated with cholestasis and/or fat malabsorption. The aim of this study was to determine vitamin K of bone, vitamin D and parathyroid hormone status in patients with biliary and pancreatic disorders. In 90 consecutive patients (mean +/- SD age, 65.5 +/- 17.7 years; 45 females) undergoing endoscopic retrograde cholangiopancreatography (68 with choledocholithiasis, 14 with other benign condition, and 8 with cholangiopancreatic cancers) fasting concentrations of carboxylated (cOC) and undercarboxylated osteocalcin (ucOC), 25-hydroxyvitamin D, calcium, phosphorus, magnesium, prothrombin time, liver function tests, lipase, and creatinine were measured...
September 2009: Nutrition Research
John J Grzesiak, Michael Bouvet
We have previously demonstrated that pathophysiological shifts in the concentrations of extracellular Mg(2+) and Ca(2+) activate the alpha(2)beta(1) integrin-mediated malignant phenotype on type I collagen in pancreatic cancer cells, as evidenced by increased adhesion, migration and proliferation. In the present study, we examined the integrin and divalent cation specificity of pancreatic cancer cell interactions with other physiologically relevant extracellular matrix proteins, including fibronectin, type IV collagen, laminin and vitronectin...
August 2008: Cancer Science
John J Grzesiak, Michael Bouvet
The authors have previously demonstrated that alpha(2)beta(1) integrin-mediated pancreatic cancer cell adhesion to Type I collagen is Mg(2+)-dependent, inhibited by Ca(2+), and that this integrin, purified from cell lysates using Type I-collagen-sepharose in Mg(2+), can be eluted with Ca(2+). In the present study, the authors examined the divalent cation-dependency of alpha(2)beta(1) integrin-mediated pancreatic cancer cell adhesion, migration and proliferation on Type I collagen, an extracellular matrix protein shown to be highly up-regulated, and to promote the malignant phenotype in vitro and in vivo...
May 15, 2008: International Journal of Cancer. Journal International du Cancer
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