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Endometrioid adenocarcinoma

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https://www.readbyqxmd.com/read/27924672/endometrioid-adenocarcinoma-arising-from-endometriosis-of-the-pelvic-peritoneum-mimicking-advanced-ovarian-cancer-a-case-report
#1
Gee Hoon Lee, Mi Sun Kim, Min Chul Choi, Sang Geun Jung, Ah-Young Kwon, Haeyoun Kang, Kyoung Ah Kim
No abstract text is available yet for this article.
December 7, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27919969/cyclins-a-b-e-and-p27-in-endometrial-endometrioid-adenocarcinoma
#2
Simi Santala, Anne Talvensaari-Mattila, Ylermi Soini, Paula Kuvaja, Markku Santala
BACKGROUND/AIM: We have previously shown that cyclin A, B and E hold prognostic significance in endometrial endometrioid adenocarcinoma. The aim of this study was to investigate the impact of cyclin-dependent kinase inhibitor p27 on cancer-specific survival and other clinicopathological variables, as well as further analyze the relationship between p27 and cyclins A, B and E and their combined relation to prognosis in the disease. PATIENTS AND METHODS: The study comprised of 211 patients surgically treated for endometrial endometrioid adenocarcinoma at the Oulu University Hospital between 1992 and 2000...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27903930/metachronous-uterine-endometrioid-adenocarcinoma-and-peritoneal-mesothelioma-in-lynch-syndrome-a-case-report
#3
Yuxin Lu, Sara Milchgrub, Gaurav Khatri, Purva Gopal
Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma that developed in a Lynch syndrome patient 10 months after diagnosis of uterine endometrioid adenocarcinoma. To our knowledge, this is the first reported case of a Lynch syndrome patient with metachronous uterine endometrioid adenocarcinoma and primary peritoneal mesothelioma...
November 30, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27899784/-effectiveness-of-carboplatin-plus-taxane-chemotherapy-for-advanced-or-recurrent-uterine-serous-carcinoma
#4
Takuto Matsuura, Isao Otsuka
OBJECTIVE: Uterine serous carcinoma(USC)is more aggressive compared to endometrioid adenocarcinoma, and often exhibits intraperitoneal spread, resulting in a poor prognosis. It is a rare subtype of uterine cancers, accounting for 5%of cases in Japan; therefore, optimal chemotherapy regimens for patients with advanced or recurrent disease have not been established. In the present study, we evaluated the safety and efficacy of carboplatin plus taxane chemotherapy for the treatment of patients withadvanced and recurrent USC...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27803529/a-rare-benign-tumor-and-an-associated-malignancy-case-report-of-ovarian-fibroma-with-minor-sex-cord-elements-and-uterine-endometrioid-adenocarcinoma
#5
G Shilpa, E Gomathy, M L Harendra Kumar, M Anil Kumar Sakalecha
No abstract text is available yet for this article.
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27801764/tissue-based-immunohistochemical-biomarker-accuracy-in-the-diagnosis-of-malignant-glandular-lesions-of-the-uterine-cervix-a-systematic-review-of-the-literature-and-meta-analysis
#6
Sandra Lee, Marianne S Rose, Vikrant V Sahasrabuddhe, Rachel Zhao, Máire A Duggan
Immunohistochemistry is widely used to support a pathology diagnosis of cervical adenocarcinoma despite the absence of a systematic review and meta-analysis of the published data. This systematic review and meta-analysis was performed to investigate the sensitivity and specificity of immunohistochemistry biomarkers in the tissue-based diagnosis of cervical adenocarcinoma histotypes compared with normal endocervix and benign glandular lesions. The systematic review and meta-analysis used a PICOT framework and QUADAS-2 to evaluate the quality of included studies...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27798902/genomic-characterisation-and-response-to-trastuzumab-and-paclitaxel-in-advanced-or-recurrent-her2-positive-endometrial-carcinoma
#7
Martin Koskas, Jeroen Depreeuw, Stijn Moens, Daniela Annibali, Tine Cuppens, Philippe Moerman, Diether Lambrechts, Frederic Amant
BACKGROUND/AIM: Human epidermal growth factor receptor 2 (HER2) positivity is associated with a worse prognosis in endometrial cancer (EC). Trastuzumab as a single agent did not demonstrate activity in such cases but there are no reports on its combined use with taxanes. We report the outcome in patients treated simultaneously with trastuzumab and paclitaxel for advanced or recurrent HER2-positive endometrial carcinoma and compared it to their microsatellite instability (MSI) status and PIK3CA mutational profiles...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27793358/adjuvant-radiation-therapy-is-associated-with-improved-overall-survival-in-high-intermediate-risk-stage-i-endometrial-cancer-a-national-cancer-data-base-analysis
#8
Vishal Gupta, Mary McGunigal, Monica Prasad-Hayes, Tamara Kalir, Jerry Liu
PURPOSE: Adjuvant radiation therapy (RT) was shown to improve local control in patients with high-intermediate risk (HIR) stage I endometrial cancer (EC) in randomized trials. Overall survival (OS) was not significantly different with adjuvant RT in these trials or subsequent meta-analyses; however, they were underpowered to assess OS. We used the National Cancer Data Base (NCDB) to examine the impact of adjuvant RT on OS in HIR EC patients. METHODS: The NCDB was queried for patients diagnosed with FIGO (2009) Stage I endometrioid adenocarcinoma from 1998 to 2012 who underwent surgery±adjuvant RT...
October 25, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27780688/patterns-of-care-in-women-with-high-intermediate-risk-endometrioid-adenocarcinoma-in-the-portec-2-era-a-seer-database-analysis
#9
Peter J Zavitsanos, Kara L Leonard
PURPOSE: We examined the radiotherapy patterns of care over an 8-year period during which the PORTEC-2 trial and other series were published. METHODS AND MATERIALS: Patients diagnosed with Stage I endometrioid adenocarcinoma (EA) between 2004 and 2011 were identified in the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Adjuvant radiation treatments were analyzed by year. Patterns of care from 2004 to 2008 were compared to those from 2009 to 2011 using the χ(2) test...
October 22, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27768222/histologic-subtypes-of-ovarian-carcinoma-selected-diagnostic-and-classification-problems-in-bulgaria-is-low-hospital-volume-an-issue
#10
Vesela Ivanova, Tihomir Dikov, Nadya Dimitrova
PURPOSE: To provide an overview of the morphologic subtypes of ovarian carcinomas in Bulgaria in relation to current healthcare organization using Bulgarian National Cancer Registry data. Further, we investigated hospital volume as a factor influencing the quality of care for patients with ovarian cancer. METHODS: Bulgarian National Cancer Registry ovarian carcinoma data were retrieved (2009-2011) and distribution of histologic types was analyzed. Cases were divided and compared with respect to main treatment: no surgery, surgery at hospitals dealing with ≥30 ovarian cancer patients/year (high volume), and surgery at hospitals dealing with <30 ovarian cancer patients/year (low volume)...
October 8, 2016: Tumori
https://www.readbyqxmd.com/read/27759595/survival-differences-among-uterine-papillary-serous-clear-cell-and-grade-3-endometrioid-adenocarcinoma-endometrial-cancers-a-national-cancer-database-analysis
#11
Mary McGunigal, Jerry Liu, Tamara Kalir, Manjeet Chadha, Vishal Gupta
OBJECTIVES: High-risk histology including UPSC, CC, and high-grade (G3) endometrioid adenocarcinoma (EAC) have a worse prognosis compared to G1-2 EAC. It is unknown whether G3EAC outcomes are more similar to UPSC/CC or to G1-2 EAC. The purpose of this study was to compare overall survival (OS) among UPSC, CC, and G1-3 EAC, for International Federation of Gynecology and Obstetrics stages I to III. METHODS: The National Cancer Data Base was queried for patients diagnosed with International Federation of Gynecology and Obstetrics (1988 classification) Stage I-III UPSC, CC, and EAC from 1998 to 2012 who underwent surgery as definitive treatment...
October 18, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27757531/-metastatic-mechanisms-of-uterine-malignancies-and-therapeutic-consequences
#12
S F Lax, K F Tamussino, P F Lang
Malignancies of the uterus metastasize by direct invasion of neighboring structures, lymphatically or hematogenously. Endometrial and cervical cancers lymphatically spread to the pelvic and para-aortic lymph nodes. For endometrial cancer the depth of myometrial invasion, lymphosvascular space involvement (LVSI) and a microcystic, elongated and fragmented (MELF) glandular invasion pattern are predictors for lymph node metastases. Metastases to the pelvic lymph nodes occur in approximately 10 % of endometrial cancer patients and in 30 % of these cases the para-aortic lymph nodes are also involved...
October 18, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27746268/association-of-ovarian-hyperthecosis-with-endometrial-polyp-endometrial-hyperplasia-and-endometrioid-adenocarcinoma-in-postmenopausal-women-a-clinicopathologic-study-of-238-cases
#13
Cunxian Zhang, C James Sung, M Ruhul Quddus, Rochelle A Simon, Tarek Jazaerly, W Dwayne Lawrence
Ovarian hyperthecosis, a source of estrogen, may occur in postmenopausal women. In this study, we evaluated the possible association of ovarian hyperthecosis with endometrial polyp, endometrial hyperplasia, and endometrioid adenocarcinoma in postmenopausal women. Our study consisted of 238 postmenopausal women: 108 with endometrioid adenocarcinoma and 130 without endometrial carcinoma. The International Federation of Gynecology and Obstetrics system was used to grade endometrioid adenocarcinoma. Within the endometrioid adenocarcinoma cases, 48 (44...
October 13, 2016: Human Pathology
https://www.readbyqxmd.com/read/27745917/prospective-evaluation-of-the-molecular-effects-of-metformin-on-the-endometrium-in-women-with-newly-diagnosed-endometrial-cancer-a-window-of-opportunity-study
#14
Pamela T Soliman, Qian Zhang, Russell R Broaddus, Shannon N Westin, David Iglesias, Mark F Munsell, Rosemarie Schmandt, Melinda Yates, Lois Ramondetta, Karen H Lu
OBJECTIVE: Metformin reduces cancer incidence and improves overall survival in diabetic patients. In preclinical studies, metformin decreases endometrial cancer (EC) cell growth by activation of AMPK/mTOR inhibition. We sought to determine the effects of metformin on serum/tumor biomarkers in women with EC. METHODS: In this prospective trial, newly diagnosed EC patients underwent pre-treatment blood draw/endometrial biopsy, were administered oral metformin 850mg daily for ≥7days, and underwent post-treatment blood draw/definitive surgery...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27743738/impact-of-histology-and-surgical-approach-on-survival-among-women-with-early-stage-high-grade-uterine-cancer-an-nrg-oncology-gynecologic-oncology-group-ancillary-analysis
#15
Amanda N Fader, James Java, Meaghan Tenney, Stephanie Ricci, Camille C Gunderson, Sarah M Temkin, Nick Spirtos, Christina L Kushnir, Michael L Pearl, Oliver Zivanovic, Krishnansu S Tewari, David O'Malley, Ellen M Hartenbach, Chad A Hamilton, Natalie S Gould, Robert S Mannel, William Rodgers, Joan L Walker
OBJECTIVES: We sought to analyze the clinicopathologic features, recurrence patterns and survival outcomes of women with high-grade uterine cancer (UC) enrolled on The Gynecologic Oncology Group (GOG) LAP2 trial. METHODS: This is a post-hoc analysis of LAP-2 patients with grade 3 endometrioid adenocarcinoma (ENDO), uterine serous (USC), clear cell (CC) and carcinosarcoma (CS). Demographics, clinicopathologic features, and recurrence patterns, were compared by histology and surgical approach...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27740968/the-microcystic-elongated-and-fragmented-melf-pattern-of-invasion-a-single-institution-report-of-464-consecutive-figo-grade-1-endometrial-endometrioid-adenocarcinomas
#16
Amy S Joehlin-Price, Kelsey E McHugh, Julie A Stephens, Zaibo Li, Floor J Backes, David E Cohn, David W Cohen, Adrian A Suarez
MELF invasion has been associated with nonvaginal recurrences and lymph node (LN) metastases in multi-institutional case control studies but has not been well examined in large single-institution cohorts. Hysterectomy specimens with FIGO 1 endometrioid endometrial carcinoma and lymphadenectomies from 2007 to 2012 were identified. Electronic medical records and histologic slides were reviewed. Of 464 identified cases, 163 (35.1%) were noninvasive, 60 (12.9%) had MELF, 222 (47.8%) had a component of the infiltrative invasion pattern without MELF, 13 (2...
October 12, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27721290/minimal-deviation-adenocarcinoma-of-endometrium-a-rare-entity-in-a-72-year-old-female
#17
Thambi Renu, Mathew Siji, N Shilpa, A Vijayalakhmi
Minimal deviation adenocarcinoma (MDA) of endometrium is considered a differentiated state of endometrioid adenocarcinoma. It is a low-grade tumor associated with areas histologically typical of endometrioid adenocarcinoma in the majority of the cases. Due to deceptively benign microscopy, MDA may be overlooked leading to incorrect assessment of tumor extend and staging.
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27718528/childhood-body-mass-index-growth-trajectories-and-endometrial-cancer-risk
#18
Julie Aarestrup, Michael Gamborg, Kate Tilling, Lian G Ulrich, Thorkild I A Sørensen, Jennifer L Baker
Previously, we found that excess weight already in childhood has positive associations with endometrial cancer; however, associations with changes in body mass index (BMI) during childhood are not well understood. Therefore, we examined whether growth in childhood BMI is associated with endometrial cancer and its sub-types. A cohort of 155,505 girls from the Copenhagen School Health Records Register with measured weights and heights at the ages of 6-14 years and born 1930-1989 formed the analytical population...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27711077/relb-nf-%C3%AE%C2%BAb-links-cell-cycle-transition-and-apoptosis-to-endometrioid-adenocarcinoma-tumorigenesis
#19
Qiu-Lin Ge, San-Hong Liu, Zhi-Hong Ai, Min-Fang Tao, Li Ma, Shan-Yun Wen, Miao Dai, Fei Liu, Han-Shao Liu, Rong-Zhen Jiang, Zhuo-Wei Xue, Yu-Hang Jiang, Xiao-Hua Sun, Yi-Ming Hu, Yong-Xu Zhao, Xi Chen, Yu Tao, Xiao-Lu Zhu, Wen-Jing Ding, Bing-Qing Yang, Dan-Dan Liu, Xiao-Ren Zhang, Yin-Cheng Teng
Dysfunction of nuclear factor-κB (NF-κB) signaling has been causally associated with numerous human malignancies. Although the NF-κB family of genes has been implicated in endometrial carcinogenesis, information regarding the involvement of central regulators of NF-κB signaling in human endometrial cancer (EC) is limited. Here, we investigated the specific roles of canonical and noncanonical NF-κB signaling in endometrial tumorigenesis. We found that NF-κB RelB protein, but not RelA, displayed high expression in EC samples and cell lines, with predominant elevation in endometrioid adenocarcinoma (EEC)...
October 6, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27703679/prognostic-impact-of-primary-tumor-suvmax-on-preoperative-18-f-fluoro-2-deoxy-d-glucose-positron-emission-tomography-and-computed-tomography-in-endometrial-cancer-and-uterine-carcinosarcoma
#20
Tamaki Yahata, Shigetaka Yagi, Yasushi Mabuchi, Yuko Tanizaki, Aya Kobayashi, Madoka Yamamoto, Mika Mizoguchi, Sakiko Nanjo, Michihisa Shiro, Nami Ota, Sawako Minami, Masaki Terada, Kazuhiko Ino
The objective of the present study was to investigate the usefulness of the maximum standardized uptake value (SUVmax) of the primary tumor on preoperative (18)F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography and computed tomography (PET/CT) as a prognostic indicator in patients with endometrial neoplasms. A total of 75 patients with endometrial cancer or uterine carcinosarcoma who underwent surgical treatment were included in the present study. All patients underwent preoperative PET/CT, and the correlation between the SUVmax of the primary tumor and clinical outcomes was analyzed...
October 2016: Molecular and Clinical Oncology
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