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Endometrioid adenocarcinoma

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https://www.readbyqxmd.com/read/29137657/p53-aberrations-in-low-grade-endometrioid-carcinoma-of-the-endometrium-with-nodal-metastases-possible-insights-on-pathogenesis-discerned-from-immunohistochemistry
#1
Oluwole Fadare, Vinita Parkash
BACKGROUND: TP53 mutations are rarely identified in low grade endometrioid carcinoma of the endometrium, and their pathogenic significance in such tumors is evidenced by the fact that TP53 aberrations have been associated with reduced recurrence-free survival in this subset of tumors. However, TP53 aberrations may not always represent a driving molecular event in a given endometrial cancer with a mutation. In this case study, the immunophenotype of a distinctive low grade endometrioid adenocarcinoma with an unusual pattern of lymph node metastases is used to explore the possible roles for underlying TP53-related molecular events in its pathogenesis...
November 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/29135516/international-endocervical-adenocarcinoma-criteria-and-classification-iecc-a-new-pathogenetic-classification-for-invasive-adenocarcinomas-of-the-endocervix
#2
Simona Stolnicu, Iulia Barsan, Lien Hoang, Prusha Patel, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Malcolm C Pike, Esther Oliva, Kay J Park, Robert A Soslow
We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World Health Organization 2014 classification. The International Endocervical Adenocarcinoma Criteria and Classification (IECC criteria), described herein, distinguishes between human papillomavirus-associated adenocarcinoma (HPVA), recognized by the presence of luminal mitoses and apoptosis seen at scanning magnification, and no or limited HPVA features (nonhuman papillomavirus-associated adenocarcinoma [NHPVA])...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29135119/expression-and-significance-of-arid1a-mrna-in-endometriosis-associated-ovarian-cancer
#3
Qiong Wang, Lingxiong Wang, Yali L, Xiaohui Ding, Aijun Liu
PURPOSE: To investigate the expression and relevant clinical and pathological significance of AT-rich interactive domaincontaining protein 1A (ARID1A) mRNA in endometriosis-associated ovarian cancer. METHODS: The clinical and pathological data of 63 patients with ovarian clear cell carcinoma (OCCC) and of 43 patients with ovarian endometrioid adenocarcinoma (OEAC) were collected. The expression of ARID1A-encoded protein, baf250a, in ovarian cancer tissues was detected using immunohistochemistry...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29129333/pitfalls-in-the-interpretation-of-specimens-from-patients-with-testicular-tumours-with-an-emphasis-on-variant-morphologies
#4
REVIEW
Thomas M Ulbright
Accurate diagnosis of primary and metastatic tumours is essential in testicular cancer. While many cases are straightforward, some pose difficulties, especially when variant morphologies occur. Seminoma with 'atypical' features, including increased nuclear pleomorphism and crowding and greater cytoplasmic density with loss of membrane definition, mimics embryonal carcinoma, although ancillary features (fibrous septa, lymphocytes) and immunohistochemistry are of great help. Other deceptive seminoma features include prominent to exclusive intertubular growth, microcystic/tubular patterns, and signet-ring tumour cells...
November 9, 2017: Pathology
https://www.readbyqxmd.com/read/29128439/robotic-splenectomy-for-isolated-splenic-recurrence-of-endometrial-adenocarcinoma
#5
Valerio Gallotta, Marco D'Indinosante, Camilla Nero, Maria Teresa Giudice, Carmine Conte, Claudio Lodoli, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
OBJECTIVES: We present a rare case of an isolated intraparenchymal splenic metastasis of endometrial cancer managed with robotic-assisted surgery. METHODS: A 55-year-old patient with a history of endometrial cancer was found to have a splenic lesion during her follow-up exams. She underwent surgical staging (total hysterectomy, bilateral salpingo-oopherectomy, pelvic lymphadenectomy and peritoneal washing) in 2014 and the final pathologic findings showed an endometrioid endometrial adenocarcinoma, FIGO Stage IB G2...
November 8, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29109365/improvement-in-5-year-relative-survival-in-cancer-of-the-corpus-uteri-from-1993-2000-to-2001-2006-in-japan
#6
Shusaku Inoue, Satoyo Hosono, Hidemi Ito, Isao Oze, Yoshikazu Nishino, Masakazu Hattori, Tomohiro Matsuda, Isao Miyashiro, Tomio Nakayama, Mika Mizuno, Keitaro Matsuo, Kiyoko Kato, Hideo Tanaka, Yuri Ito
BACKGROUND: Medical circumstances in Japanese patients with cancer of the corpus uteri have greatly changed since the late 1990s, including the introduction of concomitant therapy with taxane and platinum. We evaluated changes in survival rates for this cancer following these advances by analyzing data from population-based cancer registries in Japan. METHODS: Data were available for 8562 cases of cancer of the corpus uteri from six prefectural cancer registries...
November 4, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29096350/endometrioid-adenocarcinoma-originating-simultaneously-from-endometrium-sites-of-adenomyosis-and-ovarian-endometriosis-a-case-report-and-review-of-our-cancer-database
#7
Lena Tashima, Kensuke Hori, Hitomi Ono, Teruaki Nagano, Shin-Ichi Nakatsuka, Kimihiko Ito
INTRODUCTION: Although adenomyosis is a common disease, it is a relatively rare site for cancer origin. On the other hand, chocolate cysts have the potential to develop into cancer. We report a case of endometrioid adenocarcinoma occurred at three sites simultaneously; uterine endometrium, adenomyosis and ovarian endometriosis. PRESENTATION OF CASE: A 51-year-old woman underwent total hysterectomy and bilateral salpingo-oophorectomy after a diagnosis of corpus cancer (endometrioid adenocarcinoma, G1) stage IA...
October 30, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29093822/ezh2-inhibition-in-arid1a-mutated-clear-cell-and-endometrioid-ovarian-and-endometrioid-endometrial-cancers
#8
REVIEW
Jill K Alldredge, Ramez N Eskander
Clear cell carcinoma and endometrioid adenocarcinoma are histologic subtypes of ovarian and uterine cancer that demonstrate unique clinical behavior but share common underlying genomic aberrations and oncogenic pathways. ARID1A mutations are more frequently identified in these tumors, in comparison to other gynecologic histologies, and loss of ARID1A tumor suppressor function is thought to be an essential component of carcinogenic transformation. Several therapeutic targets in ARID1A mutated cancers are in development, including EZH2 inhibitors...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/29084048/clinical-targeted-next-generation-sequencing-shows-increased-mutational-load-in-endometrioid-type-endometrial-adenocarcinoma-with-deficient-dna-mismatch-repair
#9
Paul J Lee, Samantha McNulty, Eric J Duncavage, Jonathan W Heusel, Ian S Hagemann
A subset of endometrial adenocarcinomas (EACs) exhibit microsatellite instability and have deficient DNA mismatch repair (dMMR). The overall aim of the study was to compare the spectrum of mutations in endometrioid-type EAC with and without dMMR by using a clinically validated next-generation sequencing assay. We retrospectively identified 19 EACs with known mismatch repair status that had undergone targeted sequencing of a panel of cancer-related genes. The mismatch repair status was ascertained by immunohistochemistry against MLH1, PMS2, MSH2, and MSH6 mismatch proteins...
October 27, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29083987/amide-proton-transfer-mr-imaging-of-endometrioid-endometrial-adenocarcinoma-association-with-histologic-grade
#10
Yukihisa Takayama, Akihiro Nishie, Osamu Togao, Yoshiki Asayama, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Okamoto, Nobuhiro Fujita, Kenzo Sonoda, Tomoyuki Hida, Yoshihiro Ohishi, Jochen Keupp, Hiroshi Honda
Purpose To evaluate the utility of amide proton transfer (APT) imaging in estimating histologic grades of endometrioid endometrial adenocarcinoma (EEA). Materials and Methods The institutional review board approved this prospective study. Between June 2012 and March 2016, 32 patients with EEA underwent magnetic resonance (MR) imaging. After their surgical procedures, their EEAs were confirmed pathologically and classified into histologic grades: grade 1 (n = 11), grade 2 (n = 11), and grade 3 (n = 10). The APT signal intensities (SIs) and the mean and minimum apparent diffusion coefficients (ADCs) of the three grades were calculated and compared...
October 30, 2017: Radiology
https://www.readbyqxmd.com/read/29079795/comprehensive-single-cell-transcriptome-analysis-reveals-heterogeneity-in-endometrioid-adenocarcinoma-tissues
#11
Shinichi Hashimoto, Yuta Tabuchi, Hideaki Yurino, Yoshihiko Hirohashi, Shungo Deshimaru, Takuya Asano, Tasuku Mariya, Kenshiro Oshima, Yuzuru Takamura, Yoshiaki Ukita, Akio Ametani, Naoto Kondo, Norikazu Monma, Tadayuki Takeda, Sadahiko Misu, Toshitugu Okayama, Kazuho Ikeo, Tsuyoshi Saito, Shuich Kaneko, Yutaka Suzuki, Masahira Hattori, Kouji Matsushima, Toshihiko Torigoe
Single cell transcriptome analysis of a cancer tissue can provide objective assessment of subtype population or the activation of each of various microenvironment component cells. In this study, we applied our newly developed technique of single cell analysis to the myometrial infiltration side (M-side) and the endometrial side (E-side) of a human endometrioid adenocarcinoma with squamous differentiation tissues. We also analyzed spherogenic cultures derived from the same tissue to identify putative regulators of stemness in vivo...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29060967/-significance-and-expression-of-pax8-pax2-p53-and-ras-in-ovary-and-fallopian-tubes-to-origin-of-ovarian-high-grade-serous-carcinoma
#12
Y N Mao, L X Zeng, Y H Li, Y Z Liu, J Y Wu, L Li, Q Wang
Objective: To explore the origin of ovarian high grade serous carcinoma (HGSC) through analysing the expression and significance of PAX8, PAX2, p53 and RAS in the ovary and fallopian tube of different types and grades of serous carcinoma. Methods: A total of 44 cases tissue samples of ovarian tumor including 34 malignant ovarian tumor and 10 normal normal tissue (as control group) were collected from the admitted patients in Affiliated Tumor Hospital of Guangxi Medical University from January 2015 to January 2016...
October 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29060924/identification-of-key-genes-in-endometrioid-endometrial-adenocarcinoma-via-tcga-database
#13
Yanni Liu, Zeshun Yu, Fangfang Nan, Kexin Lu, Yunfang Wang, Yu Liu, Shuangyan Wei, Ruixue Wu, Ying Wang
BACKGROUND: Understanding the molecular mechanisms is important in development and therapy of endometrioid endometrial adenocarcinoma. OBJECTIVE: To identify key genes in endometrioid endometrial adenocarcinoma. METHODS: The data of mRNA, miRNA and DNA methylation were downloaded from The Cancer Genome Atlas (TCGA) database and differential analysis was performed. Then, bioinformatic analysis was used to explore the regulatory mechanisms of miRNA and DNA methylation on gene expression...
October 13, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29021811/significance-of-finding-benign-endometrial-cells-in-women-40-45-versus-46-years-or-older-on-papanicolaou-tests-and-histologic-follow-up
#14
Shanna M Colletti, Ghassan A Tranesh, Aziza Nassar
BACKGROUND: The 2014 Bethesda System recommends reporting the finding of benign-appearing, exfoliated endometrial cells on Papanicolaou (Pap) tests in women aged 45 years and older. We aimed to determine the significance of normal endometrial cells on liquid-based Pap tests in women aged 40 years and older and to correlate this finding with clinical factors and cytologic/histologic follow-up. MATERIALS AND METHODS: We retrospectively identified all women aged 40 years and older who had benign endometrial cells (BECs) on Pap tests at our institution during a 6-year period...
2017: CytoJournal
https://www.readbyqxmd.com/read/29017668/frequency-of-her2-neu-protein-expression-in-ovarian-epithelial-cancers
#15
Anum Jafri, Sarwat Rizvi
OBJECTIVE: To detect the frequency of Her-2/neu protein expression in epithelial ovarian cancers by immunohistochemistry. STUDY DESIGN: Descriptive cross-sectional study. PLACE AND DURATION OF STUDY: Department of Pathology, King Edward Medical University, Lahore, from July 2014 to May 2015. METHODOLOGY: Fifty-six cases diagnosed as epithelial ovarian cancer on histopathology were included in this study. Immunohistochemistry was performed to observe the pattern of HER2/neu protein expression in these cases...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28990139/association-between-morphological-patterns-of-myometrial-invasion-and-cancer-stem-cell-markers-in-endometrial-endometrioid-carcinoma
#16
Ji Y Park, Daegy Hong, Ji Young Park
In endometrial endometrioid adenocarcinoma (EEC), the depth of myometrial invasion (MI) is an important parameter for determining whether additional treatment is warranted. The present study investigated the association between MI patterns, cancer stem cell (CSC) phenotypes, and their clinicopathological significance in EEC. A total of 73 cases of EEC with MI were examined in this study. Haematoxylin and eosin-stained tissue specimens were analysed for MI pattern, which was categorised as infiltrating; expansile; adenomyosis (AM)-like; or microcystic, elongated, and fragmented (MELF)-type...
October 8, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28984674/targeted-genomic-profiling-reveals-recurrent-kras-mutations-in-mesonephric-like-adenocarcinomas-of-the-female-genital-tract
#17
Jelena Mirkovic, Marie McFarland, Elizabeth Garcia, Lynette M Sholl, Neal Lindeman, Laura MacConaill, Fei Dong, Michelle Hirsch, Marisa R Nucci, Charles M Quick, Christopher P Crum, W Glenn McCluggage, Brooke E Howitt
Mesonephric adenocarcinoma most commonly arises in the cervix and is presumed to be derived from normal or hyperplastic mesonephric remnants. It is characterized by recurrent KRAS mutations and lack of PIK3CA/PTEN alterations. Adenocarcinomas of the uterine corpus and ovary characterized by morphologic and immunophenotypic similarities to mesonephric adenocarcinoma have been reported. The pathogenesis of these tumors, which have been designated "mesonephric-like adenocarcinomas" is unknown, and it has been debated whether these represent mesonephric adenocarcinomas that arise in the endometrium/ovary or endometrioid adenocarcinomas that closely mimic mesonephric adenocarcinoma...
October 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28969912/dysregulation-of-mir-181c-expression-influences-recurrence-of-endometrial-endometrioid-adenocarcinoma-by-modulating-notch2-expression-an-nrg-oncology-gynecologic-oncology-group-study
#18
Eric J Devor, Jeffrey Miecznikowski, Brandon M Schickling, Jesus Gonzalez-Bosquet, Heather A Lankes, Premal Thaker, Peter A Argenta, Michael L Pearl, Susan L Zweizig, Robert S Mannel, Amy Brown, Nilsa C Ramirez, Olga B Ioffe, Kay J Park, William T Creasman, Michael J Birrer, David Mutch, Kimberly K Leslie
OBJECTIVE: Endometrial cancer can be diagnosed early and cured, yet cases that recur portend a very poor prognosis with over 10,000 women succumbing to the disease every year. In this study we addressed the question of how to recognize cases likely to recur early in the course of therapy using dysregulation of tumor microRNAs (miRNAs) as predictors. METHODS: Using the tissue collection from Gynecologic Oncology Group Study-210, we selected and analyzed expression of miRNAs in 54 recurrent and non-recurrent cases...
September 29, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28969139/immunohistochemical-study-of-er-pr-ki67-and-p53-in-endometrial-hyperplasias-and-endometrial-carcinomas
#19
Nayar Musfera Abdul Masjeed, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Maithili Mandar Kulkarni, Nidhi Pandya
INTRODUCTION: Endometrial carcinoma is the second most common gynecologic malignancy in the developing countries. Endometrial Hyperplasia (EH) is a precursor to Endometrioid Adenocarcinoma (EMAC). A 23% of Atypical Hyperplasias (AEH) progress to EMAC. AIM: This study was undertaken to analyse ER, PR, p53 and Ki67 in EH and endometrial carcinomas and attempt correlation with clinical and histopathological findings. MATERIALS AND METHODS: The present study was conducted over a period of seven years...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28958736/image-guided-high-dose-rate-intracavitary-brachytherapy-in-the-treatment-of-medically-inoperable-early-stage-endometrioid-type-endometrial-adenocarcinoma
#20
Scott E Jordan, Ida Micaily, Enrique Hernandez, J Stuart Ferriss, Curtis T Miyamoto, Shidong Li, Bizhan Micaily
PURPOSE: The purpose of this case series is to describe the treatment and outcomes of a cohort of patients with inoperable early-stage endometrioid endometrial cancer with 3D image-guided high-dose-rate (HDR) intracavitary brachytherapy. MATERIALS AND METHODS: A review was performed of patients with early-stage endometrial cancer who underwent primary radiation treatment between 2010 and 2016. Staging and treatment planning were performed CT, pelvic ultrasound, and pelvic MRI...
September 22, 2017: Brachytherapy
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