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Endometrioid adenocarcinoma

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https://www.readbyqxmd.com/read/29785550/does-tumor-grade-influence-the-rate-of-lymph-node-metastasis-in-apparent-early-stage-ovarian-cancer
#1
Dimitrios Nasioudis, Spyridon A Mastroyannis, Emily M Ko, Nawar A Latif
PURPOSE: To evaluate the prevalence of regional lymph node (LN) metastasis in patients with non-clear cell epithelial ovarian cancer apparently confined to the ovary, stratified by tumor grade. METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed (1988-2014). We identified patients with epithelial ovarian carcinoma of serous, endometrioid and mucinous histology apparently confined to the ovary who underwent extensive lymphadenectomy (defined as at least 20 lymph nodes removed)...
May 21, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29779939/endometrial-carcinoma-in-a-single-horn-of-a-bicornuate-uterus-a-case-report
#2
Khaled Gaballa, Carla Cicero, Valerio Gallotta, Gianfranco Zannoni, Giovanni Scambia
We discuss the diagnosis and the management of endometrial carcinoma in a single horn of bicornuate uterus in a 64-year-old woman as a case report. The case underwent laparoscopic radical hysterectomy and bilateral iliac lymphadenectomy. The gross examination of the uterus revealed a bicornuate uterus with a greater horn of 12 × 9 × 8 cm and a smaller horn of 10 × 3 cm. The cavity of the greater horn showed a neoplastic growth of 10 cm with infiltration of about 1,8 cm of the myometrium from whole thickness of 1...
May 17, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29770620/value-of-combined-adjuvant-chemotherapy-and-radiation-on-survival-for-stage-iii-uterine-cancer-is-less-radiation-equal-to-more
#3
Chiachien Jake Wang, Alana Christie, Michael R Folkert, Xian Jin Xie, Kevin Albuquerque
OBJECTIVE: Locally advanced endometrioid adenocarcinoma (LA-EAC) accounts for the majority of deaths for this cancer, yet there is no consensus on adjuvant treatment after surgery. Past studies suggest that combined modality treatment (CMT) may improve outcomes over treatment with chemotherapy (CT) or radiation therapy (RT, either external beam radiotherapy [EBRT] or vaginal brachytherapy [VBT]) alone. Using a large US-based population-based registry, we evaluated adjuvant CMT in LA-EAC and the relative benefit of regional EBRT compared to focused VBT...
March 6, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29769513/ovarian-endometrioid-adenocarcinoma-arising-in-endometriosis-a-case-report
#4
K Nahar, B Ferdous, N Akhter, P A Shamsunnahar, K Khatun, S A Begum, M A Aziz
Malignant transformation of ovarian endometriosis was first described in 1925 by Sampson; later on it has been described in extragonadal regions by few authors also. Ovarian endometrioid and clear cell carcinoma are highly associated with endometriosis. Here we present a case of malignant transformation of ovarian endometrioma into endometrioid adenocarcinoma and review the clinical and pathological features of these tumors. A 45-years old infertile woman diagnosed as a case of bilateral chocolate cyst with pelvic endometriosis underwent total hysterectomy with bilateral salpingo-oophorectomy...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29759073/laparoscopic-splenectomy-for-solitary-splenic-metastasis-in-a-patient-with-ovarian-cancer-with-a-long-disease-free-interval-a-case-report
#5
Katsuhiko Yasuda, Tomoo Yoshimura, Hiroaki Kitade, Hidesuke Yanagida, Naoki Hosaka
BACKGROUND: In general, splenic metastasis of epithelial ovarian cancer is considered a terminal stage resulting in widespread metastasis. Solitary splenic metastasis of epithelial ovarian cancer is rare in patients with post-treatment ovarian cancer with long disease-free intervals. CASE PRESENTATION: We report a case of a 62-year-old Japanese woman who presented with elevated serum cancer antigen 125 due to a solitary splenic metastasis of ovarian cancer. She underwent primary open cytoreduction including resection of the right ovarian cancer and postoperative chemotherapy, followed by secondary open cytoreduction and additional postoperative chemotherapy...
May 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29750708/endometrioid-adenocarcinoma-with-solitary-metastasis-to-the-appendix-mimicking-primary-appendiceal-adenocarcinoma-a-case-report-and-literature-review
#6
Qiujie Ma, Jianshe Wu
Metastatic tumors of the appendix are rare. Endometrial cancer tends to metastasize by directly invading neighboring structures; the lung, liver, bones, and brain are common sites of distant metastasis. Herein, we present a case of a solitary endometrial metastatic tumor in the appendiceal mucosa without serosal involvement that mimicked a primary adenocarcinoma of the appendix. The patient who had undergone a radical hysterectomy for an endometrioid adenocarcinoma 3 years earlier presented to the hospital with a history of persistent right-lower abdominal pain...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29731792/immunohistochemical-characterization-of-normal-ovary-and-common-epithelial-ovarian-neoplasm-with-a-monoclonal-antibody-to-cytokeratin-and-vimentin
#7
Ankita Goel, Nandam Mohan Rao, Vissa Santhi, Syam Sundar Byna, Bhavana Grandhi, Jyothi Conjeevaram
Background & Objective: The common epithelial ovarian tumors are classified into serous, mucinous, clear cell, endometrioid, the Brenner, mixed, and undifferentiated types. Cytoskeleton intermediate filament composition of ovarian tissues indicates that the cytokeratin and vimentin are observed in ovarian surface epithelium along with the common ovarian epithelial tumors. The current study aimed at investigating the cytokeratin and vimentin expression in epithelial ovarian tumors to establish a diagnostic relevance...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29725467/association-between-ovarian-cancer-and-advanced-endometriosis
#8
Michail Matalliotakis, Charoula Matalliotaki, George N Goulielmos, Evridiki Patelarou, Maria Tzardi, Demetrios A Spandidos, Aydin Arici, Ioannis Matalliotakis
We retrospectively analyzed clinicopathological data in two different countries over the past years on the association between ovarian endometriosis and ovarian carcinoma. Medical and pathological reports were evaluated from 1,000 patients with endometriosis from two different geographical areas. The prevalence and women characteristics of cases were analyzed. Endometriosis-associated ovarian cancer was present in 20 (2%) cases, among the study subjects. The observed prevalence was 12 (60%) for endometrioid carcinoma, 4 (20%) for clear cell ovarian carcinoma, 2 (10%) for serous and 2 (10%) for mucinous adenocarcinoma...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29703038/dedifferentiated-endometrioid-adenocarcinoma-with-trophoblastic-components-and-elevated-serum-alfa-fetoprotein-a-case-report-and-literature-review
#9
He Cai, Rong Zhou, Wanying Liang, Jianliu Wang
RATIONALE: Dedifferentiated endometrioid adenocarcinoma (DEAC) consisted of a combination of undifferentiated and differentiated carcinoma is more aggressive than other conventional endometrioid adenocarcinomas. PATIENT CONCERNS: A 33-year-old woman with atypical vaginal bleeding was refereed to our hospital. She had an endometrial biopsy in a local clinic which showed differentiated endometrioid carcinoma with trophoblastic components. High levels of β-Human chorionic gonadotropin (β-hCG) and alfa-fetoprotein (AFP) were detected in the patient's serum...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29682601/radical-resection-of-an-endometrioid-carcinoma-arising-from-endometriosis-in-the-round-ligament-within-the-right-canal-of-nuck-a-case-report-and-literature-review
#10
Yashiro Motooka, Takeshi Motohara, Ritsuo Honda, Hironori Tashiro, Yoshiki Mikami, Hidetaka Katabuchi
•A patient had endometrioid adenocarcinoma arising from endometriosis in the canal of Nuck.•The tumor invaded muscles in the inguinal region.•She showed favorable prognosis by radical surgery and adjuvant chemotherapy.
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29642629/17%C3%AE-hydroxysteroid-dehydrogenase-type-2-expression-is-induced-by-androgen-signaling-in-endometrial-cancer
#11
Chiaki Hashimoto, Yasuhiro Miki, Sota Tanaka, Kiyoshi Takagi, Misaki Fue, Zhulanqiqige Doe, Bin Li, Nobuo Yaegashi, Takashi Suzuki, Kiyoshi Ito
Endometrial cancer is one of the most common female pelvic cancers and has been considered an androgen-related malignancy. Several studies have demonstrated the anti-cell proliferative effect of androgen on endometrial cancer cells; however, the mechanisms of the anti-cancer effect of androgen remain largely unclear. 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), which catalyzes the conversion of E2 to E1, is known to be upregulated by androgen treatment in breast cancer cells. In this study, we therefore focused on the role of androgen on estrogen dependence in endometrial cancer...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29615163/diagnostic-accuracy-of-pelvic-mri-for-determination-of-the-cervical-involvement-in-endometrial-cancer
#12
Imrana Masroor, Sadia Rashid, Shaista Afzal, Saira Naz Sufian, Muhammad Azeemuddin
OBJECTIVE: To determine the diagnostic accuracy of pelvic MRI for assessment of the cervical involvement in endometrial cancer. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Radiology Department of the Aga Khan University Hospital, Karachi from January 2014 to December 2015. METHODOLOGY: Patients with biopsy-proven endometrial cancer were included, who had both their MRI and histopathological diagnosis performed at our institution...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29602378/-melf-pattern-in-myometrial-infiltration-in-endometrioid-adenocarcinoma-of-the-endometrium-a-retrospective-study-of-70-cases
#13
Francisco Tresserra, María Ángela Pascual, Mireia Arenas, Claudia Blancafort, María Ángeles Martínez-Lanao, Ignacio Rodríguez, Rafa Fábregas
INTRODUCTION: Endometrioid adenocarcinoma of the endometrium (EAE) usually has a favorable prognosis. Recently, the MELF (microcystic, elongated and fragmented) pattern of myometrial infiltration has been described. It is associated with lymphovascular invasion and lymph node metastasis. Seventy cases of EAE were reviewed to identify the presence of MELF and its correlation with other prognostic factors. MATERIAL AND METHODS: Hysterectomies performed for EAE during a 5-year period were reviewed, searching for MELF pattern...
April 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29545232/dedifferentiated-endometrioid-adenocarcinoma-clinicopathologic-and-immunohistochemical-features-of-five-cases
#14
Seyran Yiğit, Neşe Ekinci, Leyla Hayrullah, İrfan Öcal, İncim Bezircioğlu
OBJECTIVE: Dedifferentiated endometrioid adenocarcinoma is a recently defined uterine tumor composed of low grade endometrioid adenocarcinoma and undifferentiated carcinoma. Herein we present clinicopathologic, morphologic and immunohistochemical features of 5 dedifferentiated endometrioid adenocarcinoma cases. MATERIAL AND METHODS: All cases diagnosed as mixed endometrial adenocarcinoma (endometrioid + undifferentiated carcinoma) or dedifferentiated endometrioid adenocarcinoma between January 2008 and December 2014 were retrieved from the archives of our institution's pathology department...
March 16, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29541214/clinical-significance-and-prognostic-value-of-forkhead-box-a1-expression-in-human-epithelial-ovarian-cancer
#15
Kai Wang, Chenan Guan, Chenyan Fang, Xiaoxiao Jin, Junhui Yu, Yuquan Zhang, Lingzhi Zheng
Forkhead box (FOX) A1 is a member of the FOX family of transcription factors, which serve a function in numerous types of tumor. The present study assessed the potential role of FOXA1 in human epithelial ovarian carcinoma (EOC). Total RNA was isolated from 16 fresh-frozen EOC tumors with paired corresponding non-malignant ovarian epithelium tissues, and FOXA1 expression was analyzed using reverse transcription-quantitative polymerase chain reaction. Immunohistochemical analysis was performed to evaluate FOXA1 expression in 110 epithelial ovarian carcinoma tissue specimens (including 80 serous papillary adenocarcinoma, 9 clear cell carcinoma, 12 endometrioid adenocarcinoma, 5 mucinous carcinoma and 4 transitional cell carcinoma specimens), 24 benign ovarian tumor surface epithelium tissues and 10 normal ovarian tissue samples...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29538253/factors-predictive-of-receiving-adjuvant-radiotherapy-in-high-intermediate-risk-stage-i-endometrial-cancer
#16
Mary McGunigal, Ariel Pollock, John T Doucette, Jerry Liu, Manjeet Chadha, Tamara Kalir, Vishal Gupta
OBJECTIVES: Randomized trials have shown a local control benefit with adjuvant radiotherapy (RT) in high-intermediate-risk endometrial cancer patients, although not all such patients receive RT. We reviewed the National Cancer Data Base to investigate which patient/tumor-related factors are associated with delivery of adjuvant RT. METHODS: The National Cancer Data Base was queried for patients diagnosed with International Federation of Gynecology and Obstetrics 2009 stage I endometrioid adenocarcinoma from 1998 to 2012 who underwent surgery +/- adjuvant RT...
June 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29501813/concomitant-laparoscopic-and-thoracoscopic-resection-of-recurrent-high-grade-ovarian-cancer
#17
Roberto Tozzi, Jvan Casarin, Elizabeth Belcher, Riccardo Garruto Campanile, Lamiese Ismail, Hooman Soleymani Majd, Matteo Morotti, Marcello Desgro
STUDY OBJECTIVE: To describe the first case of combined endoscopic management of a thoracic and abdominal recurrence of ovarian cancer. DESIGN: An instructive video showing the combined thoracic and abdominal surgical procedure. SETTING: Department of Gynecological Oncology, Churchill Hospital, Oxford University, UK. PATIENTS: A 64-year-old woman undergoing endoscopic treatment for a third recurrence of ovarian cancer after a full surgical staging in 2007...
March 2, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29491073/combined-oocyte-retrieval-and-robot-assisted-hysterectomy-in-a-super-morbidly-obese-patient-with-endometrial-carcinoma
#18
Esther H Chung, Paula C Brady, Kimberly Keefe Smith, Michelle R Davis, Michael G Muto, Rachel K Ashby, Elizabeth S Ginsburg
AIM: To report on the unique, innovative management of a super morbidly obese patient presenting for fertility preservation in the setting of Grade 2 endometrioid endometrial adenocarcinoma. CASE REPORT: A back-to-back oocyte retrieval and robot-assisted total laparoscopic hysterectomy (RA-TLH) with bilateral salpingo-oophorectomy (BSO) was performed in a 37-year-old nulligravid woman with super morbid obesity (BMI 63 kg/m2 ) with endometrial cancer. MAIN OUTCOME MEASURE: the successful retrieval of oocytes for fertility preservation and oncologic intervention via RA-TLH with BSO in the same operative and anesthetic episode...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29474242/cervical-adenocarcinoma-a-comparison-of-the-reproducibility-of-the-world-health-organization-2003-and-2014-classifications
#19
Aylin Sar, Qiuli Duan, Moosa Khalil, Lisa M DiFrancesco, Carol Ewanowich, Alice Lytwyn, Bojana Djordjevic, Doha Itani, Sandra Lee, Martin Köbel, Sarah Glaze, Elena Park, Máire A Duggan
OBJECTIVE: The aim of the study was to compare the reproducibility of malignant glandular tumors of the uterine cervix classified per World Health Organization (WHO) 2003 and 2014. MATERIALS AND METHODS: Two pathologists reviewed 228 cases composed of adenocarcinoma in situ and 22 adenocarcinoma histotypes and selected 405 representative hematoxylin and eosin slides, which were digitally scanned. Six other pathologists (3 gynecological and 3 anatomical) independently reviewed and classified the images per both WHO classifications...
April 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29458899/single-port-access-laparoscopic-subtotal-hysterectomy-using-contained-manual-morcellation-experience-from-a-tertiary-referral-center-in-taiwan
#20
Shih-Shien Weng, Yi-Chun Chou, Fang-Ju Sun
OBJECTIVE: To describe the surgical outcomes of single port access laparoscopic subtotal hysterectomy (LSH) using in-bag manual morcellation and evaluate the feasibility of this procedure. MATERIALS AND METHODS: Thirty patients with symptomatic leiomyoma or adenomyosis were enrolled. A 2-cm transverse incision was made at the umbilicus and single port apparatus (LagiPort) was applied. After dissection of vesicouterine peritoneum from the uterus, the uterine ligaments and vessels were secured and transected by Gyrus PK cutting forceps...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
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