keyword
MENU ▼
Read by QxMD icon Read
search

Antidepressant augmentation

keyword
https://www.readbyqxmd.com/read/29332095/both-serum-brain-derived-neurotrophic-factor-and-interleukin-6-levels-are-not-associated-with-therapeutic-response-to-lamotrigine-augmentation-therapy-in-treatment-resistant-depressive-disorder
#1
Shoko Kagawa, Kazuo Mihara, Takeshi Suzuki, Goyo Nagai, Akifumi Nakamura, Kenji Nemoto, Tsuyoshi Kondo
BACKGROUND/AIMS: Serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) were prospectively monitored in relation with therapeutic response to lamotrigine augmentation therapy in 46 (15 males and 31 females) inpatients with treatment-resistant depressive disorder during an 8-week treatment with lamotrigine using an open-study design. METHODS: The subjects were 46 depressed patients who had already shown insufficient response to at least 3 psychotropics including antidepressants, mood stabilizers, and atypical antipsychotics...
January 12, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29331701/the-use-of-triiodothyronine-t3-in-the-treatment-of-bipolar-depression-a-review-of-the-literature
#2
REVIEW
T Parmentier, P Sienaert
BACKGROUND: There is a paucity of treatment options for bipolar depression. The use of triiodothyronine (T3) has been suggested as adjunctive treatment. METHODS: A search on Medline, Limo and ScienceDirect was performed using the search terms bipolar disorder, bipolar depression, treatment resistant, treatment refractory, thyroid hormones, triiodothyronine, T3, acceleration and augmentation. RESULTS: We retrieved three open studies, one comparative study, two double blind and one retrospective chart review...
January 9, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329045/increased-depression-symptom-score-in-newly-diagnosed-type-2-diabetes-patients
#3
Wolfgang Rathmann, Oliver Kuß, Dörte Anderson, Stefan Busch, Michael Hahn, Johanna Engelhard, Ming Zou, Karel Kostev
The aim was to investigate the association between diabetes duration and depressive symptoms in type 2 diabetes. The DIAREG registry used data of a nationwide general medicine practice database (Disease Analyzer, Germany) augmented by prospective data from patient reported outcomes (PRO) including Center of Epidemiological Studies Depression Scale (CES-D: <16 vs. ≥16) and the SF-36. Multiple logistic regression models were used to investigate the association of diabetes duration with PROs. Overall, 1807 type 2 diabetes patients were registered in 108 practices...
January 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29274869/neuromodulators-for-functional-gi-disorders-disorders-of-gut-brain-interaction-a-rome-foundation-working-team-report
#4
REVIEW
Douglas A Drossman, Jan Tack, Alexander C Ford, Eva Szigethy, Hans Törnblom, Lukas Van Oudenhove
BACKGROUND AND AIMS: Central neuromodulators (antidepressants, antipsychotics and other CNS targeted medications) are increasingly used for treatment of functional GI disorders (FGIDs), now recognized as disorders of gut-brain interaction. However, the available evidence and guidance for the use of central neuromodulators in these conditions is scanty and incomplete. In this Rome Foundation Working Team report, a multidisciplinary team summarized available research evidence and clinical experience to provide guidance and treatment recommendations...
December 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29214483/psychotherapyplus-augmentation-of-cognitive-behavioral-therapy-cbt-with-prefrontal-transcranial-direct-current-stimulation-tdcs-in-major-depressive-disorder-study-design-and-methodology-of-a-multicenter-double-blind-randomized-placebo-controlled-trial
#5
Malek Bajbouj, Sabine Aust, Jan Spies, Ana-Lucia Herrera-Melendez, Sarah V Mayer, Maike Peters, Christian Plewnia, Andreas J Fallgatter, Lukas Frase, Claus Normann, Nora Behler, Linda Wulf, Eva-Lotta Brakemeier, Frank Padberg
Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders worldwide. About 20-30% of patients do not respond to the standard psychopharmacological and/or psychotherapeutic interventions. Mounting evidence from neuroimaging studies in MDD patients reveal altered activation patterns in lateral prefrontal brain areas. Successful cognitive behavioral therapy (CBT) is associated with a recovery of these neural alterations. Moreover, it has been demonstrated that transcranial direct current stimulation (tDCS) is capable of influencing prefrontal cortex activity and cognitive functions such as working memory and emotion regulation...
December 6, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29194112/drug-associated-spontaneous-orgasm-a-case-report-and-systematic-review-of-literature
#6
Wei-Hsi Chen, Yuan-Hsiang Chu, Kuo-Yen Chen
OBJECTIVES: Spontaneous orgasm is characterized by a spontaneous onset of orgasm without any preceding sexual or nonsexual trigger. It sheds insight on the mechanisms underlying orgasms and the sexual response cycle in humans. METHODS: We report a male patient of repetitive spontaneous orgasm under trazodone treatment and systematically review the literature on drug-associated spontaneous orgasm (DASO). RESULTS: A total of 25 patients (18 women and 7 men), including our reported case, experienced 27 DASO events...
December 1, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29174531/can-we-increase-speed-and-efficacy-of-antidepressant-treatments-part-i-general-aspects-and-monoamine-based-strategies
#7
REVIEW
Francesc Artigas, Analia Bortolozzi, Pau Celada
Major depressive disorder (MDD) is a severe psychiatric syndrome with high prevalence and socioeconomic impact. Current antidepressant treatments are based on the blockade of serotonin (5-hydroxytryptamine, 5-HT) and/or noradrenaline transporters. These drugs show slow onset of clinical action and limited efficacy, partly due to the activation of physiological negative feed-back mechanisms operating through autoreceptors (5-HT1A, 5-HT1B, α2-adrenoceptors) and postsynaptic receptors (e.g., 5-HT3). As a result, clinically-relevant doses of reuptake inhibitors increase extracellular (active) 5-HT concentrations in the midbrain raphe nuclei but not in forebrain, as indicated by rodent microdialysis studies and by PET-scan studies in primate/human brain...
November 21, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29157513/antipsychotic-augmentation-for-major-depressive-disorder-a-review-of-clinical-practice-guidelines
#8
REVIEW
Peter Simons, Lisa Cosgrove, Allen F Shaughnessy, Harold Bursztajn
Clinical Practice Guidelines (CPGs) are seen as the gold standard of evidence-based care. Because of their influence, these guidelines can have profound legal and economic effects. Despite their proliferation and influence, the trustworthiness and quality of guidelines have been seriously questioned and they have been implicated as drivers of overtreatment. In the U.S, augmentation with second generation antipsychotics (SGAs) is becoming an increasingly common strategy for treating major depressive disorder (MDD) when initial antidepressant treatment does not result in remission of symptoms...
November 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29151192/impact-of-oral-ketamine-augmentation-on-hospital-admissions-in-treatment-resistant-depression-and-ptsd-a-retrospective-study
#9
John Hartberg, Simone Garrett-Walcott, Angelo De Gioannis
RATIONALE: Depressive episodes are the leading cause of mental health-related hospital admissions in Australia, and 44% of those admitted have a previous history of hospitalisations for depression (Admitted patient mental health-related care: (Australian Institute of Health and Welfare Aust Hospital Stat 2011-12, 2013). Despite numerous available antidepressant treatments, many patients do not respond to conventional therapy, having what is called 'treatment resistance' (Fava Biol Psychiatry 53:649-659, 2003)...
November 18, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29138992/use-of-ketamine-in-elderly-patients-with-treatment-resistant-depression
#10
REVIEW
Carolina Medeiros da Frota Ribeiro, Patricio Riva-Posse
PURPOSE OF REVIEW: The purpose of this paper is to provide a review of the use of ketamine as an antidepressant for treatment-resistant depression (TRD) in the geriatric population. Available treatment options for late-life treatment-resistant depression are limited and include electroconvulsive therapy and transcranial magnetic stimulation as well as possible pharmacologic augmentation. Ketamine has been shown to be a promising treatment in TRD; however, data regarding the use of ketamine in the elderly includes only five case reports...
November 15, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29131097/fluoxetine-treatment-in-rats-increases-the-rate-of-taurine-transport-in-mononuclear-cells
#11
María Gabriela Colmenares-Aguilar, Mary Urbina, Francisco Obregón, Fili Fazzino, Lucimey Lima
Fluoxetine, a selective serotonin reuptake inhibitor antidepressant, modulates the mitogen-induced proliferation of lymphocytes. Lymphocytes contain taurine and express taurine transporter (TauT). Among the effects of taurine on lymphocytes are protection against oxidants and regulation of the inflammatory aspects of the immune response. Our aim was to determine the influence of fluoxetine treatment on taurine transport, and to determine the presence of TauT in the mononuclear cells of rats. METHODS: Male adult Sprague-Dawley rats were treated with fluoxetine 10 mg/kg i...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29110139/the-place-of-antipsychotics-in-the-therapy-of-anxiety-disorders-and-obsessive-compulsive-disorders
#12
REVIEW
Baptiste Pignon, Chloé Tezenas du Montcel, Louise Carton, Antoine Pelissolo
PURPOSE OF REVIEW: The purpose of this review was to assess and present the findings up to this date on the efficacy of antipsychotics in the treatment of generalized anxiety disorders (GAD), social anxiety disorders (SAD), panic disorders (PD), and obsessive-compulsive disorders (OCD), mostly based on published randomized controlled trials (RCTs) or on open-label studies when RCT were lacking. RECENT FINDINGS: Quetiapine could be recommended in patients with GAD...
November 7, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29107818/low-comorbid-obsessive-compulsive-disorder-in-patients-with-major-depressive-disorder-findings-from-a-european-multicenter-study
#13
Markus Dold, Lucie Bartova, Daniel Souery, Julien Mendlewicz, Stefano Porcelli, Alessandro Serretti, Joseph Zohar, Stuart Montgomery, Siegfried Kasper
BACKGROUND: This cross-sectional European multicenter study examined the association between major depressive disorder (MDD) and comorbid obsessive-compulsive disorder (OCD). METHODS: Socio-demographic, clinical, and treatment features of 1346 adult MDD patients were compared between MDD subjects with and without concurrent OCD using descriptive statistics, analyses of covariance (ANCOVA), and binary logistic regression analyses. RESULTS: We determined a point prevalence of comorbid OCD in MDD of 1...
October 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29101798/cytokine-serum-levels-remain-unchanged-during-lithium-augmentation-of-antidepressants-in-major-depression
#14
Roland Ricken, Marlene Busche, Peter Schlattmann, Hubertus Himmerich, Sandra Bopp, Tom Bschor, Christoph Richter, Thomas J Stamm, Andreas Heinz, Rainer Hellweg, Undine E Lang, Mazda Adli
Lithium augmentation (LA) of antidepressants is a first-line therapy in treatment-resistant depression. Immunomodulatory effects of lithium have been described. The cytokine hypothesis of depression postulates that cytokines play a key role in the pathophysiology of depression. Concordantly, it has been shown that proinflammatory cytokine serum levels decrease during antidepressant treatment. The aim of this study was to investigate changes in cytokine serum levels during LA. Serum concentrations of the cytokines interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, tumour necrosis factor alpha, interferon-gamma, granulocyte and monocyte colony stimulating factor were measured in a total of 95 acutely depressed patients before and after four weeks of LA...
October 5, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29101244/abrogated-freud-1-cc2d1a-repression-of-5-ht1a-autoreceptors-induces-fluoxetine-resistant-anxiety-depression-like-behavior
#15
Faranak Vahid-Ansari, Mireille Daigle, M Chiara Manzini, Kenji F Tanaka, René Hen, Sean D Geddes, Jean-Claude Béïque, Jonathan James, Zul Merali, Paul R Albert
Freud-1/CC2D1A represses the gene transcription of serotonin-1A (5-HT1A) autoreceptors, which negatively regulate 5-HT tone. To test the role of Freud-1 in vivo, we generated mice with adulthood conditional knockout of Freud-1 in 5-HT neurons (cF1ko). In cF1ko mice, 5-HT1A autoreceptor protein, binding and hypothermia response were increased, with reduced 5-HT content and neuronal activity in the dorsal raphe. The cF1ko mice displayed increased anxiety- and depression-like behavior that was resistant to chronic antidepressant (fluoxetine) treatment...
November 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29080596/can-cognitive-behavioral-therapy-for-anxiety-and-depression-be-improved-with-pharmacotherapy-a-meta-analysis
#16
REVIEW
David F Tolin
The present meta-analysis examined controlled trials of pharmacologic augmentation of cognitive-behavioral therapy (CBT) for patients with anxiety or depressive disorders. The additive effect of medications was small for both anxiety and depressive disorders at posttreatment, and there was no additive benefit after medications were discontinued. A small body of evidence suggested that antidepressant medications are an efficacious second-line treatment for patients failing to respond to CBT alone. In anxiety disorders, novel agents thought to potentiate the biological mechanisms of CBT showed small effects at posttreatment; after discontinuation, some of these agents were associated with an increasing effect...
December 2017: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29064607/hypothalamic-pituitary-thyroid-hpt-axis-functioning-in-anxiety-disorders-a-systematic-review
#17
REVIEW
Susanne Fischer, Ulrike Ehlert
Depression has repeatedly been linked to subclinical hypothyroidism, and thyroid hormones have successfully been used to augment antidepressant treatment. By contrast, the extent of thyroid dysfunction in anxiety disorders remains less clear. This is surprising, given that anxiety-related symptoms (e.g., nervousness, palpitations, increased perspiration) are highly prevalent in hyperthyroidism. The present study was undertaken to synthesize the literature on hypothalamic-pituitary-thyroid (HPT) axis functioning in anxiety disorders...
October 24, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29055748/sex-and-dose-dependent-abuse-liability-of-repeated-subanesthetic-ketamine-in-rats
#18
Kristin J Schoepfer, Caroline E Strong, Samantha K Saland, Katherine N Wright, Mohamed Kabbaj
RATIONALE: Subanesthetic ketamine (KET) elicits rapid, robust, but transient antidepressant effects. KET's antidepressant actions can be augmented and maintained for a longer duration when repeatedly delivered. However, KET is recreationally abused, raising long-term treatment safety concerns. Women are more likely than men to seek treatment for depression, escalate from casual to compulsive drug use, and are more sensitive to antidepressants. Similarly, female rodents are more sensitive than males to KET's rapid antidepressant-like behavioral effects; dose-response thresholds in these assays equal 2...
October 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29030111/double-blind-proof-of-concept-poc-trial-of-low-field-magnetic-stimulation-lfms-augmentation-of-antidepressant-therapy-in-treatment-resistant-depression-trd
#19
Maurizio Fava, Marlene P Freeman, Martina Flynn, Bettina B Hoeppner, Richard Shelton, Dan V Iosifescu, James W Murrough, David Mischoulon, Cristina Cusin, Mark Rapaport, Boadie W Dunlop, Madhukar H Trivedi, Manish Jha, Gerard Sanacora, Gretchen Hermes, George I Papakostas
BACKGROUND: Low-Field Magnetic Stimulation (LFMS) is a novel, non-invasive, sub-threshold neuromodulation technique, shown in preliminary studies to have immediate mood elevating effects in both unipolar and bipolar depressed patients. OBJECTIVE: We aimed to assess the antidepressant augmentation effects at 48 h of LFMS administered on two consecutive days compared to sham treatment in treatment resistant depression (TRD) subjects, using the Sequential Parallel Comparison Design (SPCD)...
September 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29028590/efficacy-and-tolerability-of-lisdexamfetamine-as-an-antidepressant-augmentation-strategy-a-meta-analysis-of-randomized-controlled-trials
#20
Peter Giacobbe, Uros Rakita, Raymond Lam, Roumen Milev, Sidney H Kennedy, Roger S McIntyre
BACKGROUND: Psychostimulants have been used in the treatment of depression, with mixed results. This meta-analysis examines the efficacy and tolerability of the stimulant Lisdexamfetamine (LDX) as an add-on strategy in those with MDD who have failed to respond to an antidepressant. METHOD: Randomized control trials were identified and extracted from Pubmed; Web of Science; PsychINFO; and Cochrane Library. The efficacy of LDX was evaluated using Hedges' g and Odds Ratio, whereas Risk Difference was used to assess the safety and tolerability of LDX...
January 15, 2018: Journal of Affective Disorders
keyword
keyword
86292
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"