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Metabolically healthy obese children

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https://www.readbyqxmd.com/read/29569446/who-healthy-diet-to-prevent-chronic-diseases-and-caries
#1
L Paglia
For some years now, the WHO has recommended less than 10% of energy intake from free sugars. The same document also stresses the need to bring this limit below 5% as soon as possible. These guidelines have been promoted with the aim of reducing the prevalence of chronic non-communicable diseases such as diabetes, cardiovascular disease, obesity and metabolic syndrome. At the same time, the reduction of free sugars in the diet can be part of a strategy to reduce the prevalence of caries, which is known to be an infectious and transmissible multifactorial disease known to be "triggered" by wrong dietary habits...
March 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29568109/mitochondrial-inefficiency-in-infants-born-to-overweight-african-american-mothers
#2
Manjusha Abraham, Christina A Collins, Scott Flewelling, Maraya Camazine, Alison Cahill, W Todd Cade, Jennifer G Duncan
BACKGROUND: Currently 20-35% of pregnant women are obese, posing a major health risk for mother and fetus. It is postulated that an abnormal maternal-fetal nutritional environment leads to adverse metabolic programming, resulting in altered substrate metabolism in the offspring and predisposing to risks of obesity and diabetes later in life. Data indicate that oocytes from overweight animals have abnormal mitochondria. We hypothesized that maternal obesity is associated with altered mitochondrial function in healthy neonatal offspring...
March 3, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29568108/lifestyle-of-women-before-pregnancy-and-the-risk-of-offspring-obesity-during-childhood-through-early-adulthood
#3
Klodian Dhana, Geng Zong, Changzheng Yuan, Eva Schernhammer, Cuilin Zhang, Xiaobin Wang, Frank B Hu, Jorge E Chavarro, Alison E Field, Qi Sun
BACKGROUND: In women, adhering to an overall healthy lifestyle is associated with a dramatically reduced risk of cardio-metabolic disorders. Whether such a healthy lifestyle exerts an intergenerational effects on child health deserves examination. METHODS: We included 5701 children (9-14 years old at baseline) of the Growing Up Today Study 2, and their mothers, who are participants in the Nurses' Health Study II. Pre-pregnancy healthy lifestyle was defined as a normal body mass index, no smoking, physical activity ≥150 min/week, and diet in the top 40% of the Alternative Healthy Eating Index-2010...
March 3, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29531563/lipid-regulatory-genes-polymorphism-in-children-with-and-without-obesity-and-cardiometabolic-risk-factors-the-caspian-iii-study
#4
Silva Hovsepian, Shaghayegh Haghjooy Javanmard, Marjan Mansourian, Mahin Hashemipour, Mohamadhasan Tajadini, Roya Kelishadi
Background: Genetically, predisposed children are considered as at-risk individuals for cardiovascular disease. In this study, we aimed to compare the frequency of four-lipid regulatory polymorphism in obese and normal-weight children with and without cardiometabolic risk factors. Materials and Methods: In this nested case-control study, 600 samples of four groups of participants consisted of those with normal weight with and without cardiometabolic risk factors and obese with and without cardiometabolic risk factors...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29494339/the-relationship-between-diet-quality-and-insulin-resistance-in-obese-children-adaptation-of-the-healthy-lifestyle-diet-index-in-turkey
#5
Yasemin Ertaş Öztürk, Rukiye Bozbulut, Esra Döğer, Aysun Bideci, Eda Köksal
BACKGROUND: Childhood obesity and its complications are serious health problems and diet/lifestyle changes can be beneficial for the prevention of diseases. Adaptation of the Healthy Lifestyle-Diet (HLD) Index in accordance with the dietary guidelines for Turkey (TR) and determination of the relationship between metabolic syndrome risk factors in obese children were the aims of this study. METHODS: This study was conducted on 164 overweight or obese children (87 male, 77 female) aged 9-13 years...
March 1, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29458745/sleep-duration-independently-influences-metabolic-body-size-phenotype-in-children-and-adolescents-a-population-based-study
#6
Han Hyuk Lim
BACKGROUND: Epidemiologic studies have found an association between sleep duration and obesity. However, the relationship between sleep duration and metabolic body size phenotype in children and adolescents remains unknown. METHODS: In this cross-sectional study, 3650 participants (1946 boys and 1704 girls) from the Korean National Health and Nutrition Examination Survey 2007-2012 were classified into four phenotypes according to body mass index and metabolic heath status based on the definition of metabolic syndrome by NCEP-ATP III or the International Diabetes Federation...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29444663/gender-related-differences-in-cardiometabolic-risk-factors-and-lifestyle-behaviors-in-treatment-seeking-adolescents-with-severe-obesity
#7
Lisa Ha Barstad, Pétur B Júlíusson, Line Kristin Johnson, Jens Kristoffer Hertel, Samira Lekhal, Jøran Hjelmesæth
BACKGROUND: Obesity during adolescence is associated with cardiovascular mortality in adulthood. The adverse obesity-related cardiometabolic risk profile is already observed in adolescence. We aimed to examine possible gender differences in cardiometabolic risk factors and lifestyle behaviors among adolescents with severe obesity, hypothesizing that boys would have both a higher prevalence of the metabolic syndrome as well as less healthy lifestyle behaviors than girls. METHODS: Cross-sectional study of treatment-seeking adolescents with severe obesity who attended the Morbid Obesity Centre at Vestfold Hospital Trust and who were consecutively enrolled in the Vestfold Register of Obese Children between September 2009 and September 2015...
February 14, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29402762/effect-on-the-metabolic-biomarkers-in-schoolchildren-after-a-comprehensive-intervention-using-electronic-media-and-in-person-sessions-to-change-lifestyles-community-trial
#8
Jenny Vilchis-Gil, Miguel Klünder-Klünder, Samuel Flores-Huerta
BACKGROUND: Obesity is a chronic low-intensity state of inflammation with metabolic alterations that, when acquired during childhood, lead to severe illness in adults. Encouraging healthy eating habits and physical activity is the basis for preventing and treating obesity and its complications. OBJECTIVE: To evaluate how a comprehensive intervention promoting healthy eating habits and physical activities in schools affects children's metabolic biomarkers. METHODS: Of four Mexico City primary schools in this study, two groups of children that were recruited at their schools were assigned to a 12-month intervention group (IG) and the other two were assigned to control groups (CGs)...
February 5, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29399981/maternal-metabolic-health-parameters-during-pregnancy-in-relation-to-early-childhood-bmi-trajectories
#9
Parisa Montazeri, Martine Vrijheid, David Martinez, Mikel Basterrechea, Ana Fernandez-Somoano, Monica Guxens, Carmen Iñiguez, Aitana Lertxundi, Mario Murcia, Adonina Tardon, Jordi Sunyer, Damaskini Valvi
OBJECTIVE: The objective of this study was to evaluate the associations between maternal metabolic parameters and early childhood BMI trajectories. METHODS: Two thousand two hundred fifty-one children born in Spain between 2004 and 2008 were analyzed. Five BMI z score trajectories from birth to age 4 years were identified by using latent class growth analysis. Multinomial regression assessed the associations between maternal metabolic parameters and offspring's BMI trajectories...
March 2018: Obesity
https://www.readbyqxmd.com/read/29379536/bifidobacteria-and-lactobacilli-in-the-gut-microbiome-of-children-with-non-alcoholic-fatty-liver-disease-which-strains-act-as-health-players
#10
Valerio Nobili, Lorenza Putignani, Antonella Mosca, Federica Del Chierico, Pamela Vernocchi, Anna Alisi, Laura Stronati, Salvatore Cucchiara, Marco Toscano, Lorenzo Drago
Introduction: Non-alcoholic fatty liver disease (NAFLD), considered the leading cause of chronic liver disease in children, can often progress from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH). It is clear that obesity is one of the main risk factors involved in NAFLD pathogenesis, even if specific mechanisms have yet to be elucidated. We investigated the distribution of intestinal bifidobacteria and lactobacilli in the stools of four groups of children: obese, obese with NAFL, obese with NASH, and healthy, age-matched controls (CTRLs)...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29346138/obesity-and-chronic-kidney-disease
#11
Edward Nehus
PURPOSE OF REVIEW: To review recent advances in the epidemiology, pathophysiology, clinical features, and treatment of obesity-related kidney disease. RECENT FINDINGS: Studies have confirmed that obesity is associated with increased risk of developing chronic kidney disease (CKD). This risk extends to those who are metabolically healthy, indicating that obesity per se contributes to CKD independent of the metabolic syndrome. Recent developments in the pathophysiology of obesity-related kidney disease indicate that chronic inflammation and abnormal lipid metabolism contribute to kidney cell injury...
April 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29295487/infant-feeding-beliefs-attitudes-knowledge-and-practices-of-chinese-immigrant-mothers-an-integrative-review-of-the-literature
#12
REVIEW
Ana Cristina Lindsay, Qun Le, Mary L Greaney
Chinese are a fast-growing immigrant population group in several parts of the world (e.g., Australia, Canada, Europe, Southeast Asia, United States). Research evidence suggests that compared to non-Hispanic whites, individuals of Asian-origin including Chinese are at higher risk of developing cardiovascular disease and type 2 diabetes at a lower body mass index (BMI). These risks may be possibly due to genetic differences in body composition and metabolic responses. Despite the increasing numbers of Chinese children growing up in immigrant families and the increasing prevalence of obesity among Chinese, little research has been focused on children of Chinese immigrant families...
December 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29290033/effects-of-obesity-and-metabolic-syndrome-on-cardiovascular-outcomes-in-pediatric-kidney-transplant-recipients-a-longitudinal-study
#13
Kristen Sgambat, Sarah Clauss, K Y Lei, Jiuzhou Song, Shaik O Rahaman, Margaret Lasota, Asha Moudgil
BACKGROUND: Obesity and metabolic syndrome (MS) are common after kidney transplantation, but their contribution to adverse cardiovascular (CV) outcomes in children are not well known. A prospective, controlled, longitudinal cohort study was conducted to investigate the effects of obesity and MS on left ventricular hypertrophy (LVH) and myocardial strain in pediatric kidney transplant recipients. METHODS: Transplant recipients (n = 42) had anthropometrics [body mass index (BMI), waist circumference, waist-to-height ratio], biochemical parameters (fasting glucose, lipid panel, HbA1c%), and echocardiogram with speckle tracking analysis for strain measured at 1, 18, and 30 months post-transplant...
December 30, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29282082/associations-between-dietary-factors-and-obesity-related-biomarkers-in-healthy-children-and-adolescents-a-systematic-review
#14
REVIEW
Jennifer Hilger-Kolb, Catherin Bosle, Irina Motoc, Kristina Hoffmann
BACKGROUND: The obesity prevalence in children and adolescents has increased worldwide during the past 30 years. Although diet has been identified as one risk factor for developing obesity in this age group, the role of specific dietary factors is still unclear. One way to gain insight into the role of these factors might be to detect biomarkers that reflect metabolic health and to identify the associations between dietary factors and these biomarkers. This would enable nutrition-related metabolic changes to be detected early in life, which might be a promising strategy to prevent childhood obesity...
December 28, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29237763/bisphenol-a-phthalate-metabolites-and-glucose-homeostasis-in-healthy-normal-weight-children
#15
Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen, Anders Juul
INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of the Copenhagen Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dual-energy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry and fasting blood samples...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29214176/human-gut-microbiota-associated-with-obesity-in-chinese-children-and-adolescents
#16
Ya-Ping Hou, Qing-Qing He, Hai-Mei Ouyang, Hai-Shan Peng, Qun Wang, Jie Li, Xiao-Fei Lv, Yi-Nan Zheng, Shao-Chuan Li, Hai-Liang Liu, Ai-Hua Yin
Objective: To investigate the gut microbiota differences of obese children compared with the control healthy cohort to result in further understanding of the mechanism of obesity development. Methods: We evaluated the 16S rRNA gene, the enterotypes, and quantity of the gut microbiota among obese children and the control cohort and learned the differences of the gut microbiota during the process of weight reduction in obese children. Results: In the present study, we learned that the gut microbiota composition was significantly different between obese children and the healthy cohort...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29206649/the-importance-of-the-microbiome-in-pediatrics-and-pediatric-infectious-diseases
#17
Thaidra Gaufin, Nicole H Tobin, Grace M Aldrovandi
PURPOSE OF REVIEW: Emerging research on the pediatric microbiome implicates the importance of the microbiome on the development of the immune system, nervous system, and growth. Changes to the microbiome during infancy are associated with the development of chronic illnesses such as asthma and inflammatory bowel disease. Additionally, the microbiome provides protection against certain pathogens, affects vaccine responses, and alters drug metabolism. This review highlights what is known about the microbiome, the establishment of a healthy microbiome and the significance that changes to the microbiome composition have on growth and health of children and adolescents...
February 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29175807/obesity-is-a-strong-risk-factor-for-the-development-of-restless-legs-syndrome-and-poor-sleep-quality-in-children-and-adolescents
#18
Rıza Taner Baran, Müge Atar, Özgür Pirgon, Serkan Filiz, Meral Filiz
OBJECTIVE: Adult epidemiological studies have suggested that the rate of restless legs syndrome (RLS) in the general population may range from 5% to 15%. The aim of this study was to investigate the frequency of RLS in a community sample of obese adolescents aged 10-16 years and its association with sleep quality and health-related glucose metabolism markers. METHODS: The study group comprised 144 obese and overweight children aged 10-16 years [mean body mass index (BMI): 30...
November 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29171553/negative-correlation-among-vitamin-b12-levels-obesity-severity-and-metabolic-syndrome-in-obese-children-a-case-control-study
#19
Samet Ozer, Ergun Sonmezgoz, Osman Demir
OBJECTIVE: To determine the relationship among vitamin B12 status, obesity severity, and metabolic syndrome and its components in obese children.. METHODS: This case-control study was conducted at the School of Medicine, Gaziosmanpasa University, Tokat, Turkey, from January 2012 and October 2014, and comprised cases of obese and healthy children. The obese children were divided into three groups according to body mass index-standard deviation score quartiles. Group 1 included the first quartile, group 2 included the second and third quartiles, and group 3 included the fourth quartile...
November 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29108814/waist-to-height-ratio-and-sedentary-lifestyle-as-predictors-of-metabolic-syndrome-in-children-in-ecuador
#20
F Aguirre P, A Coca, M F Aguirre, G Celis
OBJECTIVE: To determine the predictors and prevalence of metabolic syndrome (MS) and the presence of vascular inflammation in apparently-normal children (10-15 years) of both sexes in Guayaquil, Ecuador. STUDY DESIGN AND METHODS: We included 395 apparently-healthy students from a middle-income school in a cross-sectional survey. Informed consent was obtained from students and parents. Anthropometric measurements including blood pressure (BP), body mass index (BMI) and waist-to-height ratio (WHtR), and blood tests were recorded...
November 3, 2017: Hipertensión y Riesgo Vascular
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