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Metabolically healthy obese children

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https://www.readbyqxmd.com/read/29237763/bisphenol-a-phthalate-metabolites-and-glucose-homeostasis-in-healthy-normal-weight-children
#1
Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen, Anders Juul
INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of The COPENHAGEN Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dualenergy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry, and fasting blood samples...
December 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29214176/human-gut-microbiota-associated-with-obesity-in-chinese-children-and-adolescents
#2
Ya-Ping Hou, Qing-Qing He, Hai-Mei Ouyang, Hai-Shan Peng, Qun Wang, Jie Li, Xiao-Fei Lv, Yi-Nan Zheng, Shao-Chuan Li, Hai-Liang Liu, Ai-Hua Yin
Objective: To investigate the gut microbiota differences of obese children compared with the control healthy cohort to result in further understanding of the mechanism of obesity development. Methods: We evaluated the 16S rRNA gene, the enterotypes, and quantity of the gut microbiota among obese children and the control cohort and learned the differences of the gut microbiota during the process of weight reduction in obese children. Results: In the present study, we learned that the gut microbiota composition was significantly different between obese children and the healthy cohort...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29206649/the-importance-of-the-microbiome-in-pediatrics-and-pediatric-infectious-diseases
#3
Thaidra Gaufin, Nicole H Tobin, Grace M Aldrovandi
PURPOSE OF REVIEW: Emerging research on the pediatric microbiome implicates the importance of the microbiome on the development of the immune system, nervous system, and growth. Changes to the microbiome during infancy are associated with the development of chronic illnesses such as asthma and inflammatory bowel disease. Additionally, the microbiome provides protection against certain pathogens, affects vaccine responses, and alters drug metabolism. This review highlights what is known about the microbiome, the establishment of a healthy microbiome and the significance that changes to the microbiome composition have on growth and health of children and adolescents...
December 4, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29175807/obesity-is-a-strong-risk-factor-for-the-development-of-restless-legs-syndrome-and-poor-sleep-quality-in-children-and-adolescents
#4
Rıza Taner Baran, Müge Atar, Özgür Pirgon, Serkan Filiz, Meral Filiz
OBJECTIVE: Adult epidemiological studies have suggested that the rate of restless legs syndrome (RLS) in the general population may range from 5% to 15%. The aim of this study was to investigate the frequency of RLS in a community sample of obese adolescents aged 10-16 years and its association with sleep quality and health-related glucose metabolism markers. METHODS: The study group comprised 144 obese and overweight children aged 10-16 years [mean body mass index (BMI): 30...
November 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29171553/negative-correlation-among-vitamin-b12-levels-obesity-severity-and-metabolic-syndrome-in-obese-children-a-case-control-study
#5
Samet Ozer, Ergun Sonmezgoz, Osman Demir
OBJECTIVE: To determine the relationship among vitamin B12 status, obesity severity, and metabolic syndrome and its components in obese children.. METHODS: This case-control study was conducted at the School of Medicine, Gaziosmanpasa University, Tokat, Turkey, from January 2012 and October 2014, and comprised cases of obese and healthy children. The obese children were divided into three groups according to body mass index-standard deviation score quartiles. Group 1 included the first quartile, group 2 included the second and third quartiles, and group 3 included the fourth quartile...
November 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29108814/waist-to-height-ratio-and-sedentary-lifestyle-as-predictors-of-metabolic-syndrome-in-children-in-ecuador
#6
F Aguirre P, A Coca, M F Aguirre, G Celis
OBJECTIVE: To determine the predictors and prevalence of metabolic syndrome (MS) and the presence of vascular inflammation in apparently-normal children (10-15 years) of both sexes in Guayaquil, Ecuador. STUDY DESIGN AND METHODS: We included 395 apparently-healthy students from a middle-income school in a cross-sectional survey. Informed consent was obtained from students and parents. Anthropometric measurements including blood pressure (BP), body mass index (BMI) and waist-to-height ratio (WHtR), and blood tests were recorded...
November 3, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/29093301/adipokines-are-associated-with-hypertension-in-metabolically-healthy-obese-mho-children-and-adolescents-a-prospective-population-based-cohort-study
#7
Wenqing Ding, Hong Cheng, Fangfang Chen, Yinkun Yan, Meixian Zhang, Xiaoyuan Zhao, Dongqing Hou, Jie Mi
BACKGROUND: The potential mechanism underlying the relationship between the risk of cardiovascular diseases and metabolically healthy obese (MHO) individuals remains unclear. The aim of the study was to prospectively investigate the potential role of the adipokines in the association between the MHO phenotype and hypertension in children and adolescents. METHODS: A total of 1184 participants at baseline were recruited from a cohort of the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study...
October 25, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29073291/-direction-of-change-in-the-somatic-development-in-children-and-adolescents-with-type-1-diabetes
#8
Honorata Kołodziejczyk, Małgorzata Wajda-Cuszlag, Anna Świercz, Mieczysław Szalecki
INTRODUCTION: Disorders of somatic development in children and adolescents with type 1 diabetes can lead to unstable course of the disease and the difficulties in obtaining good metabolic control. AIM: Evaluation of somatic development in children and adolescents with type 1 diabetes in different age categories. MATERIAL AND METHODS: Agroup of 97 girls and 90 boys with type 1 diabetes was examined. Children were divided into three age groups: girls with mean age of 9...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29040067/early-onset-severe-obesity-due-to-complete-deletion-of-the-leptin-gene-in-a-boy
#9
Elif Ozsu, Serdar Ceylaner, Huseyin Onay
BACKGROUND: Monogenic obesity results from single gene mutations. Extreme obesity starting at an early age, especially in infancy, which is associated with endocrinopathy and metabolic disturbances is key to the diagnosis of monogenic obesity. CASE PRESENTATION: A 6-month-old boy was admitted to our clinic with severe obesity and food craving. He was born with a birth weight of 3400 g to first-cousin parents. He started to gain weight at an abnormal rate at the age of 2 months...
October 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28987250/differences-between-metabolically-healthy-vs-unhealthy-obese-children-and-adolescents
#10
Aditi Khokhar, Vivian Chin, Sheila Perez-Colon, Tanni Farook, Shipra Bansal, Elna Kochummen, Vatcharapan Umpaichitra
Obesity is on the rise worldwide. An obesity subtype, metabolically healthy obese (MHO), is resilient to unfavorable metabolic and cardiovascular effects. Factors predicting MHO phenotype are not well characterized. We aimed to identify MHO and metabolically unhealthy obese (MUO) children and adolescents with respect to metabolic factors, and to find predictors of MHO subtype. A retrospective chart review was done on children, ages 4-19 years, 99% African-American/Caribbean, with BMI ≥95th %tile. MUO was defined as meeting ≥1 of the following: fasting glucose ≥100 mg/dl, HbA1c >5...
2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28984255/risk-factors-for-cardiovascular-disease-in-obese-children
#11
T Chandrasekhar, M M Suchitra, M Pallavi, P V L N Srinivasa Rao, Alok Sachan
OBJECTIVE: To study the prevalence of cardiovascular risk factors in pediatric obesity. METHODS: 50 obese children (age 5-17y) and 50 apparently healthy non-obese children (body mass index of over 95th percentile and between 5th to 95th percentiles, respectively) using Centre for Disease Control growth charts were included. Fasting blood sugar, lipid profile, insulin, homeostasis model assessment of insulin resistance, uric acid, fibrinogen, lipoprotein (a), homocysteine, malondialdehyde, ferric reducing ability of plasma and nitric oxide were measured...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28960038/prevalence-and-clinical-characteristics-of-metabolically-healthy-obesity-in-korean-children-and-adolescents-data-from-the-korea-national-health-and-nutrition-examination-survey
#12
Da Young Yoon, Young Ah Lee, Jieun Lee, Jae Hyun Kim, Choong Ho Shin, Sei Won Yang
Metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) are differentiated by the presence of cardiometabolic risk factors (CMRFs) and insulin resistance (IR). This study aimed to evaluate the prevalence and clinical characteristics of MHO in Korean children and adolescents and to investigate the anthropometric, laboratory, and lifestyle predictors of MHO. This study included data from 530 obese subjects, aged 10-19 years, obtained from the Fourth Korea National Health and Nutrition Examination Survey...
November 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28886253/female-offspring-born-to-obese-and-insulin-resistant-dams-are-not-at-increased-risk-for-obesity-and-metabolic-dysfunction-during-early-development
#13
Hanin Aburasayn, Rami Al Batran, Keshav Gopal, Malak Almutairi, Amina Eshreif, Farah Eaton, John Ussher
The percentage of women who are obese at the time of conception/pregnancy is increasing, with animal and human studies demonstrating that offspring born to obese dams/mothers are at increased risk for obesity and the metabolic syndrome. Our goal was to confirm in an experimental model of metabolic syndrome in the dam, whether the offspring would be at increased risk of obesity. Conversely, we observed that male offspring born to dams with metabolic syndrome had no alterations in their body weight profiles, whereas female offspring born to dams with metabolic syndrome were heavier at weaning, but exhibited no perturbations in energy metabolism...
September 8, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28885093/heart-rate-recovery-time-in-metabolically-healthy-and-metabolically-unhealthy-obese-children
#14
Ljiljana Bjelakovic, Vladimir Vukovic, Marko Jovic, Sanja Bankovic, Tomislav Kostic, Dragan Radovanovic, Sasa Pantelic, Mladen Zivkovic, Sanja Stojanovic, Bojko Bjelakovic
BACKGROUND: Autonomic dysfunction is an emerging non-traditional cardiovascular risk factor that correlates with obesity, components of metabolic syndrome, as well as cardiorespiratory fitness. As a simple and validated index of autonomic balance, heart rate recovery (HRR) has been reported as a useful biomarker for predicting cardiovascular morbidity and mortality. OBJECTIVES: The aim of this study was to compare HRR in metabolically healthy vs. metabolically unhealthy obese children...
September 13, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28816926/feasibility-and-relevance-of-antipsychotic-safety-monitoring-in-children-with-tourette-syndrome-a-prospective-longitudinal-study
#15
Tamara Pringsheim, Josephine Ho, Justyna R Sarna, Tracy Hammer, Scott Patten
PURPOSE/BACKGROUND: Antipsychotics are efficacious for tics and are increasingly prescribed to children with behavioral disorders. Antipsychotics have important adverse effects, and systematic monitoring of drug safety is infrequently performed. The objectives of this study were to determine the feasibility of antipsychotic safety monitoring in children with Tourette Syndrome using a defined protocol and to evaluate the risk of adverse effects with chronic use. METHODS/PROCEDURES: A prospective longitudinal study of children prescribed antipsychotics was performed...
October 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28815857/association-between-short-sleep-duration-and-body-mass-index-in-australian-indigenous-children
#16
Melissa Deacon-Crouch, Isabelle Skinner, Joseph Tucci, Timothy Skinner
AIM: Associations between short sleep duration and obesity and the relationship between obesity and chronic illness are well documented. Obese children are likely to become obese adults. To date, there is a paucity of information regarding sleep duration and quality for Indigenous Australian people. It may be that poor-quality, short sleep is contributing to the gap in health outcomes for Indigenous people compared with non-Indigenous adults and children. This study sought to investigate the possibility that poor sleep quality may be contributing to health outcomes for Indigenous children by exploring associations between sleep duration and body mass index (BMI)...
August 16, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28782888/physical-activity-and-sedentary-time-associations-with-metabolic-health-across-weight-statuses-in-children-and-adolescents
#17
Nicholas Kuzik, Valerie Carson, Lars Bo Andersen, Luís B Sardinha, Anders Grøntved, Bjørge Herman Hansen, Ulf Ekelund
OBJECTIVE: The aim of this study was to examine the prevalence of metabolic health across weight statuses and the associations of physical activity and sedentary time within and across metabolic health-weight status groups. METHODS: Six studies (n = 4,581) from the International Children's Accelerometry Database were used. Sedentary time, light physical activity, and moderate to vigorous physical activity (MVPA) were accelerometer derived. Individuals were classified with normal weight (NW), overweight, or obesity...
August 7, 2017: Obesity
https://www.readbyqxmd.com/read/28759573/alternation-of-plasma-fatty-acids-composition-and-desaturase-activities-in-children-with-liver-steatosis
#18
Man-Chin Hua, Hui-Min Su, Tsung-Chieh Yao, Ming-Ling Kuo, Ming-Wei Lai, Ming-Han Tsai, Jing-Long Huang
OBJECTIVE: The aim of this study was to investigate changes in plasma fatty acids proportions and estimated desaturase activities for variable grading of liver steatosis in children. METHODS: In total, 111 schoolchildren (aged 8-18 years) were included in the analysis from March 2015 to August 2016. Anthropometric evaluation, liver ultrasound examination and scoring for nonalcoholic fatty liver disease (NAFLD score = 0-6), and biochemical and plasma fatty acids analysis were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28749784/concentrations-of-leptin-adiponectin-and-other-metabolic-parameters-in-non-obese-children-with-down-syndrome
#19
Nikhil Tenneti, Devi Dayal, Sheetal Sharda, Inusha Panigrahi, Mohammed Didi, Savita Verma Attri, Naresh Sachdeva, Anil Kumar Bhalla
BACKGROUND: Recent data indicates that adults with Down syndrome (DS) are at increased risk for cardiovascular disease (CVD) that significantly contributes to their morbidity and mortality. Although identification of cardiometabolic risk factors during childhood is desirable to design preventive interventions, the data on such risk factors in children with DS is scarce. The aim of this study was to study the cardiometabolic risk factors such as insulin resistance (IR), leptin and adiponectin concentrations, lipid abnormalities and leptin resistance in non-obese children with DS...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28745334/evaluation-of-the-wrist-worn-actigraph-wgt3x-bt-for-estimating-activity-energy-expenditure-in-preschool-children
#20
C Delisle Nyström, J Pomeroy, P Henriksson, E Forsum, F B Ortega, R Maddison, J H Migueles, M Löf
BACKGROUND/OBJECTIVES: Easy-to-use and accurate methods to assess free-living activity energy expenditure (AEE) in preschool children are required. The aims of this study in healthy preschool children were to (a) evaluate the ability of the wrist-worn ActiGraph wGT3x-BT to predict free-living AEE and (b) assess wear compliance using a 7-day, 24-h protocol. SUBJECTS/METHODS: Participants were 40 Swedish children (5.5±0.2 years) in the Mobile-based intervention intended to stop obesity in preschoolers (MINISTOP) obesity prevention trial...
October 2017: European Journal of Clinical Nutrition
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