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Emil F Coccaro, Royce Lee, Michael McCloskey, John G Csernansky, Lei Wang
BACKGROUND: Impulsive aggressive behavior is thought to be facilitated by activation of the limbic brain, particularly the amygdala and hippocampus., Functional imaging studies suggest abnormalities in limbic brain activity during emotional information processing in impulsively aggressive subjects with Intermittent Explosive Disorder (IED). It is not known if IED is associated with altered amygdala and hippocampus volume and shape. METHODS: We examined the volume and shape of the amygdala-hippocampal complex, using morphometric analysis of high resolution structural 3T MR scans in healthy control (HC: n = 73) subjects without history of Axis I or II psychiatric conditions and in subjects with IED (n = 67)...
October 2015: Journal of Psychiatric Research
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