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https://www.readbyqxmd.com/read/28335230/fluorescent-nanocomposite-of-embedded-ceria-nanoparticles-in-crosslinked-pva-electrospun-nanofibers
#1
Nader Shehata, Soha Gaballah, Effat Samir, Aya Hamed, Marwa Saad
This paper introduces a new fluorescent nanocomposite of electrospun biodegradable nanofibers embedded with optical nanoparticles. In detail, this work introduces the fluorescence properties of PVA nanofibers generated by the electrospinning technique with embedded cerium oxide (ceria) nanoparticles. Under near-ultra violet excitation, the synthesized nanocomposite generates a visible fluorescent emission at 520 nm, varying its intensity peak according to the concentration of in situ embedded ceria nanoparticles...
June 1, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28301707/authenticity-best-interest-and-clinical-nudging
#2
Søren Holm
In this issue of the Hastings Center Report, Moti Gorin, Steven Joffe, Neal Dickert, and Scott Halpern offer a comprehensive defense of the use of nudging techniques in the clinical context, with the aim of promoting the best interests of patients. Their argument is built on three important claims: Nudging is ubiquitous and inescapable in clinical choice situations, and there is no neutral way of informing patients about their treatment choices; many patients do not have authentic (preexisting) preferences concerning their treatment choices, and those that do can easily resist nudging; and, finally, since many people lack authentic preferences and those that do can still act on their preferences, nudging in the patients' best interest is justified...
March 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28121081/familial-melanoma-and-multiple-primary-melanoma
#3
Paola DE Simone, Michele Valiante, Vitaliano Silipo
Cutaneous Melanoma (CM) is the most deadly of the common skin cancers and its incidence is rising worldwide contributing to significant health care burden (2). CM is considered the most lethal skin cancer if it is not detected and treated during its early stages (2). Susceptibility to CM is also associated with an increased presence of atypical nevi and the occurrence of multiple primary melanoma. Personal history of CM increases 5-8% the risk of developing a second melanoma. Finally, family history of melanoma has been widely associated with an increased melanoma risk (1)...
January 24, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28032280/fluorescent-nanocomposite-of-embedded-ceria-nanoparticles-in-electrospun-chitosan-nanofibers
#4
Nader Shehata, Effat Samir, Soha Gaballah, Aya Hamed, Marwa Saad, Mohammed Salah
This paper introduces a detailed optical characterization for a novel fluorescent biodegradable nanocomposite of electro-spun chitosan nanofibers with in-situ embedded cerium oxide (ceria) nanoparticles as the nanocomposite optical fluorescent material. Under near ultra-violet excitation, this synthesized nanocomposite emits a visible green wavelength at nearly 520nmwith different intensities according to the concentration of the embedded fluorescent material; i.e. ceria nanoparticles. This emission is due to the synthesized ceria nanoparticles optical tri-valiant cerium ions ce(3+), associated with formed oxygen vacancies with a direct allowed bandgap around 3...
December 28, 2016: Journal of Fluorescence
https://www.readbyqxmd.com/read/27994872/air-bubbles-are-released-by-thoracic-endograft-deployment-an-in-vitro-experimental-study
#5
Kamuran Inci, Giasemi Koutouzi, Valery Chernoray, Anders Jeppsson, Håkan Nilsson, Mårten Falkenberg
PURPOSE: Embolic stroke is a dreaded complication of thoracic endovascular aortic repair. The prevailing theory about its cause is that particulate debris from atherosclerotic lesions in the aortic wall are dislodged by endovascular instruments and embolize to the brain. An alternative source of embolism might be air trapped in the endograft delivery system. The aim of this experimental study was to determine whether air is released during deployment of a thoracic endograft. METHODS: In an experimental benchtop study, eight thoracic endografts (five Medtronic Valiant Thoracic and three Gore TAG) were deployed in a water-filled transparent container drained from air...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/27918580/correction-gene-expansion-shapes-genome-architecture-in-the-human-pathogen-lichtheimia-corymbifera-an-evolutionary-genomics-analysis-in-the-ancient-terrestrial-mucorales-mucoromycotina
#6
Volker U Schwartze, Sascha Winter, Ekaterina Shelest, Marina Marcet-Houben, Fabian Horn, Stefanie Wehner, Jörg Linde, Vito Valiante, Michael Sammeth, Konstantin Riege, Minou Nowrousian, Kerstin Kaerger, Ilse D Jacobsen, Manja Marz, Axel A Brakhage, Toni Gabaldón, Sebastian Böcker, Kerstin Voigt
[This corrects the article DOI: 10.1371/journal.pgen.1004496.].
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27908809/a-combination-of-thoracic-and-abdominal-stent-grafts-to-treat-an-abdominal-aortic-aneurysm-with-hostile-proximal-neck
#7
Mafalda Massara, Roberto Prunella, Pasquale Gerardi, Giovanni De Caridi, Raffaele Serra, Stefano Notarstefano, Giovanni Impedovo
Endovascular aneurysm repair (EVAR) actually represents the treatment of choice for most patients affected by abdominal aortic aneurysm (AAA). However, the feasibility of EVAR depends on anatomical characteristics of abdominal aorta and iliofemoral axis. We present the case of an 82-year-old man affected by severe left hydronephrosis, kidney tumor, and ureteral tumor requiring nephrectomy, who also presented a very voluminous AAA with a large diameter (96 mm), and a large proximal neck (39 mm) with severe angulation of the proximal neck (>60°)...
February 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27904769/disruption-of-actin-filaments-and-suppression-of-pancreatic-cancer-cell-viability-and-migration-following-treatment-with-polyisoprenylated-cysteinyl-amides
#8
Augustine T Nkembo, Olufisayo Salako, Rosemary A Poku, Felix Amissah, Elizabeth Ntantie, Hernan Flores-Rozas, Nazarius S Lamango
Pancreatic cancer is characterized by K-Ras mutations in over 90% of the cases. The mutations make the tumors aggressive and resistant to current therapies resulting in very poor prognoses. Valiant efforts to drug mutant K-Ras and related proteins for the treatment of cancers with Ras mutations have been elusive. The need thus persists for therapies to target and suppress the hyperactive K-Ras mutant proteins to normal levels of activity. Polyisoprenylated cysteinyl amide inhibitors (PCAIs) of polyisoprenylated methylated protein methyl esterase (PMPMEase) were designed to disrupt polyisoprenylated protein metabolism and/or functions...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27887897/nomenclature-and-diagnosis-of-gluten-related-disorders-a-position-statement-by-the-italian-association-of-hospital-gastroenterologists-and-endoscopists-aigo
#9
REVIEW
Luca Elli, Danilo Villalta, Leda Roncoroni, Donatella Barisani, Stefano Ferrero, Nicoletta Pellegrini, Maria Teresa Bardella, Flavio Valiante, Carolina Tomba, Antonio Carroccio, Massimo Bellini, Marco Soncini, Renato Cannizzaro, Gioacchino Leandro
BACKGROUND: "Gluten-related disorders" is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively studying them. AIM: To support gastroenterologists with a correct nomenclature and diagnostic approach to gluten-related disorders in adulthood. METHODS: The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of gluten-related disorders, focusing on those of gastroenterological interest...
February 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27876000/comparison-of-repair-of-peripheral-nerve-transection-in-predegenerated-muscle-with-and-without-a-vein-graft
#10
COMPARATIVE STUDY
Jamshid Mohammadi, Hamdollah Delaviz, Bahram Mohammadi, Hamoun Delaviz, Parastou Rad
BACKGROUND: Despite substantial research into the topic and valiant surgical efforts, reconstruction of peripheral nerve injury remains a challenging surgery. This study was conducted to evaluate the effectiveness of axonal regeneration of a transected sciatic nerve through a vein conduit containing degenerated skeletal muscle compared with axonal regeneration in a transected sciatic nerve through degenerated skeletal muscle alone. METHODS: In two of the three experimental rat groups, 10 mm of the left sciatic nerve was transected and removed...
November 22, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27844043/geostatistical-analysis-of-trace-elements-pxrf-dataset-of-near-surface-semi-arid-soils-from-central-botswana
#11
Peter N Eze, Valiant S Mosokomani, Theophilus K Udeigwe, Opeoluwa F Oyedele, Adeniyi F Fagbamigbe
Geospatial dataset of trace elements including manganese (Mn), iron (Fe), titanium (Ti), rubidium (Rb), strontium (Sr), thorium (Th), Vanadium (V) and Zirconium (Zr) of near-surface soils in a Cu-Ni prospecting field at Airstrip North, Central Botswana were statistically analysed. Grid sampling method was used in the field data collection. The relatively new portable X-ray fluorescence spectrometer (Delta Premium, 510890, USA) technology in a "soil" mode was used to measure the concentrations of trace elements in the soils...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27829460/renal-function-estimation-and-cockroft-gault-formulas-for-predicting-cardiovascular-mortality-in-population-based-cardiovascular-risk-heart-failure-and-post-myocardial-infarction-cohorts-the-heart-omics-in-ageing-homage-and-the-high-risk-myocardial-infarction
#12
João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Kevin Duarte, Sophie Girerd, Marc A Pfeffer, John J V McMurray, Bertram Pitt, Kenneth Dickstein, Lotte Jacobs, Jan A Staessen, Javed Butler, Roberto Latini, Serge Masson, Alexandre Mebazaa, Hans Peter Brunner-La Rocca, Christian Delles, Stephane Heymans, Naveed Sattar, J Wouter Jukema, John G Cleland, Faiez Zannad, Patrick Rossignol
BACKGROUND: Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease Study (MDRD4), and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The CKD-EPI is the most accurate eGFR estimator as compared to a "gold-standard"; however, which of the latter is the best formula to assess prognosis remains to be clarified...
November 10, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27796292/quantifying-unobserved-protein-coding-variants-in-human-populations-provides-a-roadmap-for-large-scale-sequencing-projects
#13
James Zou, Gregory Valiant, Paul Valiant, Konrad Karczewski, Siu On Chan, Kaitlin Samocha, Monkol Lek, Shamil Sunyaev, Mark Daly, Daniel G MacArthur
As new proposals aim to sequence ever larger collection of humans, it is critical to have a quantitative framework to evaluate the statistical power of these projects. We developed a new algorithm, UnseenEst, and applied it to the exomes of 60,706 individuals to estimate the frequency distribution of all protein-coding variants, including rare variants that have not been observed yet in the current cohorts. Our results quantified the number of new variants that we expect to identify as sequencing cohorts reach hundreds of thousands of individuals...
October 31, 2016: Nature Communications
https://www.readbyqxmd.com/read/27732794/regulation-and-role-of-fungal-secondary-metabolites
#14
Juliane Macheleidt, Derek J Mattern, Juliane Fischer, Tina Netzker, Jakob Weber, Volker Schroeckh, Vito Valiante, Axel A Brakhage
Fungi have the capability to produce a tremendous number of so-called secondary metabolites, which possess a multitude of functions, e.g., communication signals during coexistence with other microorganisms, virulence factors during pathogenic interactions with plants and animals, and in medical applications. Therefore, research on this topic has intensified significantly during the past 10 years and thus knowledge of regulatory mechanisms and the understanding of the role of secondary metabolites have drastically increased...
November 23, 2016: Annual Review of Genetics
https://www.readbyqxmd.com/read/27635231/recent-advances-in-targeted-therapy-for-ewing-sarcoma
#15
REVIEW
Kathleen I Pishas, Stephen L Lessnick
Ewing sarcoma is an aggressive, poorly differentiated neoplasm of solid bone that disproportionally afflicts the young. Despite intensive multi-modal therapy and valiant efforts, 70% of patients with relapsed and metastatic Ewing sarcoma will succumb to their disease. The persistent failure to improve overall survival for this subset of patients highlights the urgent need for rapid translation of novel therapeutic strategies. As Ewing sarcoma is associated with a paucity of mutations in readily targetable signal transduction pathways, targeting the key genetic aberration and master regulator of Ewing sarcoma, the EWS/ETS fusion, remains an important goal...
2016: F1000Research
https://www.readbyqxmd.com/read/27617281/quantitative-geospatial-dataset-on-the-near-surface-heavy-metal-concentrations-in-semi-arid-soils-from-maibele-airstrip-north-central-botswana
#16
Peter N Eze, Valiant S Mosokomani, Theophilus K Udeigwe, Opeoluwa F Oyedele
This article contains a statistically analyzed dataset of the heavy metals including Cr, Co, Ni, Cu, Zn and Pb contents of near-surface (~30 cm depth) soils in a Cu-Ni prospecting field at Airstrip North, Central Botswana. The soils developed on paragneisses and amphibolites parent materials in a semi-arid environment with hardveld vegetation, "The geology of the Topisi area" (Key et al., 1994) [1]. Grid sampling was adopted in the field data collection. Heavy metals were determined using the relatively new portable x-ray fluorescence spectrometer (Delta Premium, 510,890, USA) technology in a "soil" mode...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27611015/functional-reconstitution-of-a-fungal-natural-product-gene-cluster-by-advanced-genome-editing
#17
Jakob Weber, Vito Valiante, Christina S Nødvig, Derek J Mattern, Rebecca A Slotkowski, Uffe H Mortensen, Axel A Brakhage
Filamentous fungi produce varieties of natural products even in a strain dependent manner. However, the genetic basis of chemical speciation between strains is still widely unknown. One example is trypacidin, a natural product of the opportunistic human pathogen Aspergillus fumigatus, which is not produced among different isolates. Combining computational analysis with targeted gene editing, we could link a single nucleotide insertion in the polyketide synthase of the trypacidin biosynthetic pathway and reconstitute its production in a nonproducing strain...
January 20, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27609048/meningioangiomatosis-a-disease-with-many-radiological-faces
#18
Fábio A Nascimento, Tim-Rasmus Kiehl, Peter C Tai, Taufik A Valiante, Timo Krings
No abstract text is available yet for this article.
November 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27576185/closed-loop-interruption-of-hippocampal-ripples-through-fornix-stimulation-in-the-non-human-primate
#19
Omid Talakoub, Andrea Gomez Palacio Schjetnan, Taufik A Valiante, Milos R Popovic, Kari L Hoffman
BACKGROUND: Hippocampal sharp-wave ripples (SWRs) arising from synchronous bursting in CA3 pyramidal cells and propagating to CA1 are thought to facilitate memory consolidation. Stimulation of the CA3 axon collaterals comprising the hippocampal commissure in rats interrupts sharp-wave ripples and leads to memory impairment. In primates, however, these commissural collaterals are limited. Other hippocampal fiber pathways, like the fornix, may be potential targets for modulating ongoing hippocampal activity, with the short latencies necessary to interrupt ripples...
November 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27499801/an-improved-four-russians-method-and-sparsified-four-russians-algorithm-for-rna-folding
#20
Yelena Frid, Dan Gusfield
BACKGROUND: The basic RNA secondary structure prediction problem or single sequence folding problem (SSF) was solved 35 years ago by a now well-known [Formula: see text]-time dynamic programming method. Recently three methodologies-Valiant, Four-Russians, and Sparsification-have been applied to speedup RNA secondary structure prediction. The sparsification method exploits two properties of the input: the number of subsequence Z with the endpoints belonging to the optimal folding set and the maximum number base-pairs L...
2016: Algorithms for Molecular Biology: AMB
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