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https://www.readbyqxmd.com/read/29720205/retrograde-type-a-dissection-in-a-24th-gestational-week-pregnant-patient-the-importance-of-interdisciplinary-interaction-to-a-successful-outcome
#1
Jerry Easo, Michael Horst, Bernhard Schmuck, Rohit Philip Thomas, Steffen Saupe, Malte Book, Alexander Weymann
BACKGROUND: Type A Dissection in pregnancy is a devastating medical condition with 2 lives at stake and unclear strategy at early gestational stages. We describe a successful outcome, clearly dependent on the coordination of all involved disciplines. CASE PRESENTATION: This case history describes a 28 year old female with a 24th week pregnancy gravida 2 para 0 with a DeBakey Type I aortic dissection, diagnosed via ultrasound. Surgery was perfomed on the day of diagnosis...
May 2, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29708542/a-simple-flow-cytometry-based-assay-to-determine-in-vitro-antibody-dependent-enhancement-of-dengue-virus-using-zika-virus-convalescent-serum
#2
William G Valiant, Joseph J Mattapallil
Antibody dependent enhancement of infection has been shown to play a major role in Dengue viral pathogenesis. Traditional assays that measure the capacity of antibodies or serum to enhance infection in impermissible cell lines have relied on using viral output in the media followed by plaque assays to quantify infection. More recently, these assays have examined Dengue virus (DENV) infection in the cell lines using fluorescently labeled antibodies. Both these approaches have limitations that restrict the widespread use of these techniques...
April 10, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29701421/rapid-pacing-for-thoracic-endovascular-aortic-repair-a-case-report
#3
Hugo Silva, Andreia Fernandes, João Rodrigues, Daniel Brandão, Manuela Vieira, Catarina Celestino
INTRODUCTION: Endovascular aortic interventions are suitable alternatives to open surgery, being less invasive and having lower mortality and complications. Accurate positioning of the stent graft is a critical point because of systolic thrush. Techniques used to prevent it include pharmacological (antihypertensive drugs, nitroglycerin, adenosine) and mechanical methods (temporary caval occlusion by balloon). Rapid Right Ventricular Pacing (RRVP) is an emerging alternative with good patient tolerance and low level of complications...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29680298/experimental-evaluation-of-homemade-distal-stent-graft-fenestration-for-thoracic-endovascular-aortic-repair-of-type-a-dissection-by-a-transapical-approach
#4
Thomas Gandet, Anis Seghrouchni, Baris Ata Ozdemir, Guillaume Captier, Roland Demaria, Pierre Alric, Bernard Albat, Ludovic Canaud
OBJECTIVE: The use of off-the-shelf stent grafts for thoracic endovascular aortic repair of type A dissections is limited by variability in both the length of the ascending aorta and the location of the proximal intimal tear. This experimental study aimed to assess the feasibility of using a physician-modified thoracic aortic stent graft to treat acute type A dissection by a transapical cardiac approach. METHODS: The experiments were performed on six cadaveric human heart, ascending aorta, aortic arch, and descending aorta specimens...
April 18, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29651829/incidental-finding-of-an-xq-microdeletion-in-a-girl-with-trichorhinophalangeal-syndrome-type-i-harboring-a-novel-trps1-nonsense-mutation
#5
Giulia Pascolini, Michele Valiante, Silvia Majore, Filomena Cariola, Luigi Laino, Mauro Calvani, Paola Grammatico
No abstract text is available yet for this article.
April 12, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29605455/integration-of-in-vitro-biorelevant-dissolution-and-in-silico-pbpk-model-of-carvedilol-to-predict-bioequivalence-of-oral-drug-products
#6
Manuel Ibarra, Cristian Valiante, Patricia Sopeña, Alejandra Schiavo, Marianela Lorier, Marta Vázquez, Pietro Fagiolino
Bioequivalence implementation in developing countries where a high proportion of similar drug products are being marketed has found several obstacles, impeding regulatory agencies to move forward with this policy. Biopharmaceutical quality of these products, several of which are massively prescribed, remains unknown. In this context, an in vitro-in silico-in vivo approach is proposed as a mean to screen product performance and target specific formulations for bioequivalence assessment. By coupling in vitro biorelevant dissolution testing in USP-4 Apparatus (flow-through cell) with physiologically-based pharmacokinetic (PBPK) modeling in PK-Sim® software (Bayer, Germany), the performance of seven similar products of carvedilol tablets containing 25 mg available in the Uruguayan market were compared with the brand-name drug Dilatrend®...
March 29, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29540824/author-correction-exploring-the-alpha-desynchronization-hypothesis-in-resting-state-networks-with-intracranial-electroencephalography-and-wiring-cost-estimates
#7
Jaime Gómez-Ramírez, Shelagh Freedman, Diego Mateos, José Luis Pérez Velázquez, Taufik A Valiante
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447733/stroke-risk-in-patients-with-reduced-ejection-fraction-after-myocardial-infarction-without-atrial-fibrillation
#8
João Pedro Ferreira, Nicolas Girerd, John Gregson, Ichraq Latar, Abhinav Sharma, Marc A Pfeffer, John J V McMurray, Azmil H Abdul-Rahim, Bertram Pitt, Kenneth Dickstein, Patrick Rossignol, Faiez Zannad
BACKGROUND: Stroke can occur after myocardial infarction (MI) in the absence of atrial fibrillation (AF). OBJECTIVES: This study sought to identify risk factors (excluding AF) for the occurrence of stroke and to develop a calibrated and validated stroke risk score in patients with MI and heart failure (HF) and/or systolic dysfunction. METHODS: The datasets included in this pooling initiative were derived from 4 trials: CAPRICORN (Effect of Carvedilol on Outcome After Myocardial Infarction in Patients With Left Ventricular Dysfunction), OPTIMAAL (Optimal Trial in Myocardial Infarction With Angiotensin II Antagonist Losartan), VALIANT (Valsartan in Acute Myocardial Infarction Trial), and EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study); EPHESUS was used for external validation...
February 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29371582/the-cell-wall-integrity-signaling-pathway-and-its-involvement-in-secondary-metabolite-production
#9
REVIEW
Vito Valiante
The fungal cell wall is the external and first layer that fungi use to interact with the environment. Every stress signal, before being translated into an appropriate stress response, needs to overtake this layer. Many signaling pathways are involved in translating stress signals, but the cell wall integrity (CWI) signaling pathway is the one responsible for the maintenance and biosynthesis of the fungal cell wall. In fungi, the CWI signal is composed of a mitogen-activated protein kinase (MAPK) module. After the start of the phosphorylation cascade, the CWI signal induces the expression of cell-wall-related genes...
December 6, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29349361/endovascular-repair-of-an-innominate-artery-pseudoaneurysm-using-the-valiant-mona-lsa-branched-graft-device
#10
Josh A Sibille, Joel P Harding, Jocelyn K Ballast, Mohammad Hooshmand, Jeko M Madjarov, Frank R Arko
A 60-year-old woman involved in a motor vehicle collision presented with a traumatic pseudoaneurysm of the innominate artery origin in addition to multiple concomitant injuries. She was classified as a high-risk candidate for open repair. An experimental thoracic branched graft device was used for coverage of the injury with the addition of a right carotid-to-left carotid-to-left subclavian artery bypass. Follow-up imaging showed resolution of the pseudoaneurysm and patency of her bypass grafts. This is the first described use of the Mona LSA Branch Thoracic Stent Graft System (Medtronic, Minneapolis, Minn) in the innominate artery...
March 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29314455/association-between-mean-systolic-and-diastolic-blood-pressure-throughout-the-follow-up-and-cardiovascular-events-in-acute-myocardial-infarction-patients-with-systolic-dysfunction-and-or-heart-failure-an-analysis-from-the-high-risk-myocardial-infarction-database
#11
João Pedro Ferreira, Kevin Duarte, Marc A Pfeffer, John J V McMurray, Bertram Pitt, Kenneth Dickstein, Faiez Zannad, Patrick Rossignol
BACKGROUND: Observational data have described the association of blood pressure (BP) with mortality as 'J-shaped', meaning that mortality rates increase below a certain BP threshold. We aimed to analyse the associations between BP and prognosis in a population of acute myocardial infarction (MI) patients with heart failure (HF) and/or systolic dysfunction. METHODS AND RESULTS: The datasets included in this pooling initiative are derived from four trials: CAPRICORN, EPHESUS, OPTIMAAL, and VALIANT...
February 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29298116/somatic-activating-kras-mutations-in-arteriovenous-malformations-of-the-brain
#12
Sergey I Nikolaev, Sandra Vetiska, Ximena Bonilla, Emilie Boudreau, Suvi Jauhiainen, Behnam Rezai Jahromi, Nadiya Khyzha, Peter V DiStefano, Santeri Suutarinen, Tim-Rasmus Kiehl, Vitor Mendes Pereira, Alexander M Herman, Timo Krings, Hugo Andrade-Barazarte, Takyee Tung, Taufik Valiante, Gelareh Zadeh, Mike Tymianski, Tuomas Rauramaa, Seppo Ylä-Herttuala, Joshua D Wythe, Stylianos E Antonarakis, Juhana Frösen, Jason E Fish, Ivan Radovanovic
BACKGROUND: Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in the brain vasculature, are a leading cause of hemorrhagic stroke in young adults and children. The genetic cause of this rare focal disorder is unknown. METHODS: We analyzed tissue and blood samples from patients with arteriovenous malformations of the brain to detect somatic mutations. We performed exome DNA sequencing of tissue samples of arteriovenous malformations of the brain from 26 patients in the main study group and of paired blood samples from 17 of those patients...
January 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29296883/innate-transcriptional-effects-by-adjuvants-on-the-magnitude-quality-and-durability-of-hiv-envelope-responses-in-nhps
#13
Joseph R Francica, Daniel E Zak, Caitlyn Linde, Emilio Siena, Carrie Johnson, Michal Juraska, Nicole L Yates, Bronwyn Gunn, Ennio De Gregorio, Barbara J Flynn, Nicholas M Valiante, Padma Malyala, Susan W Barnett, Pampi Sarkar, Manmohan Singh, Siddhartha Jain, Margaret Ackerman, Munir Alam, Guido Ferrari, Georgia D Tomaras, Derek T O'Hagan, Alan Aderem, Galit Alter, Robert A Seder
Adjuvants have a critical role for improving vaccine efficacy against many pathogens, including HIV. Here, using transcriptional RNA profiling and systems serology, we assessed how distinct innate pathways altered HIV-specific antibody responses in nonhuman primates (NHPs) using 8 clinically based adjuvants. NHPs were immunized with a glycoprotein 140 HIV envelope protein (Env) and insoluble aluminum salts (alum), MF59, or adjuvant nanoemulsion (ANE) coformulated with or without Toll-like receptor 4 (TLR4) and 7 agonists...
November 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29241685/fenestrated-thoracic-endovascular-aortic-repair-using-physician-modified-stent-grafts-for-acute-type-b-aortic-dissection-with-unfavourable-landing-zone
#14
Jiechang Zhu, Lujing Zhao, Xiangchen Dai, Yudong Luo, Hailun Fan, Zhou Feng, Yiwei Zhang, Fanguo Hu
OBJECTIVES: The aim was to evaluate the early results of fenestrated thoracic endovascular aortic repair (fTEVAR) using physician modified stent grafts (PMSGs) to revascularise aortic branches for acute type B aortic dissection (ABAD) with unfavourable proximal landing zone. METHODS: Twenty consecutive patients who underwent fenestrated TEVAR using PMSGs between November 2015 and December 2016 were retrospectively reviewed. Pre-, intra-, and post-operative clinical data were recorded...
February 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29171487/-evaluation-of-efficiency-and-safety-of-adding-neuromultivit-to-basic-therapy-of-vertebrogenic-radiculopathy
#15
F A Khabirov, T I Khaibullin, E V Granatov
AIM: To evaluate the efficacy and safety of neuromultivit (valiant, Russia) as add-on to the basic therapy of vertebrogenic radiculopathy (VR) L5-S1. MATERIAL AND METHODS: The open clinical trial included 100 patients with VR L5-S1 randomized into 2 groups. In group 1, patients received neuromultivit and basic therapy; in group 2 only basic therapy. Treatment efficacy was assessed by the dynamics of regression of pain intensity on the visual analogue scale (VAS), McGill pain questionnaire (MGPQ), Aberdeen back pain scale (ABPS), the Quebec Back Pain Disability Scale (QBPDS), the dynamics of neurologic symptoms, the need for additional treatment with NSAID...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29154924/characterization-of-three-novel-pathogenic-slc40a1-mutations-and-genotype-phenotype-correlations-in-7-italian-families-with-type-4-hereditary-hemochromatosis
#16
Silvia Majore, Maria Carmela Bonaccorsi di Patti, Michele Valiante, Fabio Polticelli, Andrea Cortese, Sabrina Di Bartolomeo, Carmelilia De Bernardo, Marianna De Muro, Fiorella Faienza, Francesca Clementina Radio, Paola Grammatico, Giovanni Musci
Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations. This disease can be classified as type 4A, better known as "ferroportin disease", which is due to "loss of function" mutations that lead to decreased iron export from cells, or as type 4B hemochromatosis, which is caused by "gain of function" mutations, conferring partial or complete resistance to hepcidin-mediated Fpn degradation...
February 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29142213/exploring-the-alpha-desynchronization-hypothesis-in-resting-state-networks-with-intracranial-electroencephalography-and-wiring-cost-estimates
#17
Jaime Gómez-Ramírez, Shelagh Freedman, Diego Mateos, José Luis Pérez Velázquez, Taufik A Valiante
This paper addresses a fundamental question, are eyes closed and eyes open resting states equivalent baseline conditions, or do they have consistently different electrophysiological signatures? We compare the functional connectivity patterns in an eyes closed resting state with an eyes open resting state to investigate the alpha desynchronization hypothesis. The change in functional connectivity from eyes closed to eyes open, is here, for the first time, studied with intracranial recordings. We perform network connectivity analysis in iEEG and we find that phase-based connectivity is sensitive to the transition from eyes closed to eyes open only in interhemispheral and frontal electrodes...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29098053/watering-canmeds-flowers
#18
Sarah Voll, Taufik A Valiante
We expand on the discourse related to nature surrounding Canadian medical training and the CanMEDS flower. We advance the notion that a major contributor to burnout is the increasing complexity and segregation of not only the medical profession, but society as a whole, leading to choice overload and an overemphasis on complex, data driven, rational decision making. We then propose that the key to watering CanMEDS flowers and preventing physician burnout lies in getting back to the basics of human behaviour.
June 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/29076725/rewiring-of-the-austinoid-biosynthetic-pathway-in-filamentous-fungi
#19
Derek J Mattern, Vito Valiante, Fabian Horn, Lutz Petzke, Axel A Brakhage
Filamentous fungi produce numerous high-value natural products (NPs). The biosynthetic genes for NPs are normally clustered in the genome. A valuable NP class is represented by the insecticidal austinoids. We previously determined their biosynthesis in the fungus Aspergillus calidoustus. After further computational analysis looking into the austinoid gene clusters in two additional distantly related fungi, Aspergillus nidulans and Penicillium brasilianum, a rearrangement of the genes was observed that corresponded to the diverse austinoid derivatives produced by each strain...
December 15, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29060344/low-latency-vlsi-architecture-for-neural-cross-frequency-coupling-analysis
#20
Gerard O'Leary, Taufik A Valiante, Roman Genov
Growing evidence suggests that cross-frequency coupling (CFC) is a key mechanism in neuronal computation, communication, and learning in the brain. Abnormal CFC has been implicated in pathological brain states such as epilepsy and Parkinson's disease. A reduction in excessive coupling has been shown in effective neuromodulation treatments, suggesting that CFC may be a useful feedback measure in closed-loop neural stimulation devices. However, processing latency limits the responsiveness of such systems. A VLSI architecture is presented which implements three selectable measures of CFC to enable the application specific trade-off between low-latency and high-accuracy processing...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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