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https://www.readbyqxmd.com/read/27908809/a-combination-of-thoracic-and-abdominal-grafts-to-treat-an-abdominal-aortic-aneurysm-with-hostile-proximal-neck
#1
Mafalda Massara, Roberto Prunella, Pasquale Gerardi, Giovanni De Caridi, Raffaele Serra, Stefano Notarstefano, Giovanni Impedovo
Endovascular aneurysm repair (EVAR) actually represents the treatment of choice for most patients affected by aneurysm of the abdominal aorta (AAA). However, the feasibility of EVAR depends on anatomical characteristics of abdominal aorta and ilio-femoral axis. We present the case of a 82-years old man affected by severe left hydronephrosis, kidney and ureteral tumor requiring nephrectomy, that presented also a very voluminous AAA with a large diameter (96 mm), presenting also with a large proximal neck (39 mm) and with a severe angulation of the proximal neck (> 60°)...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27904769/disruption-of-actin-filaments-and-suppression-of-pancreatic-cancer-cell-viability-and-migration-following-treatment-with-polyisoprenylated-cysteinyl-amides
#2
Augustine T Nkembo, Olufisayo Salako, Rosemary A Poku, Felix Amissah, Elizabeth Ntantie, Hernan Flores-Rozas, Nazarius S Lamango
Pancreatic cancer is characterized by K-Ras mutations in over 90% of the cases. The mutations make the tumors aggressive and resistant to current therapies resulting in very poor prognoses. Valiant efforts to drug mutant K-Ras and related proteins for the treatment of cancers with Ras mutations have been elusive. The need thus persists for therapies to target and suppress the hyperactive K-Ras mutant proteins to normal levels of activity. Polyisoprenylated cysteinyl amide inhibitors (PCAIs) of polyisoprenylated methylated protein methyl esterase (PMPMEase) were designed to disrupt polyisoprenylated protein metabolism and/or functions...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27887897/nomenclature-and-diagnosis-of-gluten-related-disorders-a-position-statement-by-the-italian-association-of-hospital-gastroenterologists-and-endoscopists-aigo
#3
REVIEW
Luca Elli, Danilo Villalta, Leda Roncoroni, Donatella Barisani, Stefano Ferrero, Nicoletta Pellegrini, Maria Teresa Bardella, Flavio Valiante, Carolina Tomba, Antonio Carroccio, Massimo Bellini, Marco Soncini, Renato Cannizzaro, Gioacchino Leandro
BACKGROUND: "Gluten-related disorders" is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively studying them. AIM: To support gastroenterologists with a correct nomenclature and diagnostic approach to gluten-related disorders in adulthood. METHODS: The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of gluten-related disorders, focusing on those of gastroenterological interest...
November 4, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27876000/comparison-of-repair-of-peripheral-nerve-transection-in-predegenerated-muscle-with-and-without-a-vein-graft
#4
Jamshid Mohammadi, Hamdollah Delaviz, Bahram Mohammadi, Hamoun Delaviz, Parastou Rad
BACKGROUND: Despite substantial research into the topic and valiant surgical efforts, reconstruction of peripheral nerve injury remains a challenging surgery. This study was conducted to evaluate the effectiveness of axonal regeneration of a transected sciatic nerve through a vein conduit containing degenerated skeletal muscle compared with axonal regeneration in a transected sciatic nerve through degenerated skeletal muscle alone. METHODS: In two of the three experimental rat groups, 10 mm of the left sciatic nerve was transected and removed...
November 22, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27844043/geostatistical-analysis-of-trace-elements-pxrf-dataset-of-near-surface-semi-arid-soils-from-central-botswana
#5
Peter N Eze, Valiant S Mosokomani, Theophilus K Udeigwe, Opeoluwa F Oyedele, Adeniyi F Fagbamigbe
Geospatial dataset of trace elements including manganese (Mn), iron (Fe), titanium (Ti), rubidium (Rb), strontium (Sr), thorium (Th), Vanadium (V) and Zirconium (Zr) of near-surface soils in a Cu-Ni prospecting field at Airstrip North, Central Botswana were statistically analysed. Grid sampling method was used in the field data collection. The relatively new portable X-ray fluorescence spectrometer (Delta Premium, 510890, USA) technology in a "soil" mode was used to measure the concentrations of trace elements in the soils...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27829460/renal-function-estimation-and-cockroft-gault-formulas-for-predicting-cardiovascular-mortality-in-population-based-cardiovascular-risk-heart-failure-and-post-myocardial-infarction-cohorts-the-heart-omics-in-ageing-homage-and-the-high-risk-myocardial-infarction
#6
João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Kevin Duarte, Sophie Girerd, Marc A Pfeffer, John J V McMurray, Bertram Pitt, Kenneth Dickstein, Lotte Jacobs, Jan A Staessen, Javed Butler, Roberto Latini, Serge Masson, Alexandre Mebazaa, Hans Peter Brunner-La Rocca, Christian Delles, Stephane Heymans, Naveed Sattar, J Wouter Jukema, John G Cleland, Faiez Zannad, Patrick Rossignol
BACKGROUND: Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease Study (MDRD4), and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The CKD-EPI is the most accurate eGFR estimator as compared to a "gold-standard"; however, which of the latter is the best formula to assess prognosis remains to be clarified...
November 10, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27796292/quantifying-unobserved-protein-coding-variants-in-human-populations-provides-a-roadmap-for-large-scale-sequencing-projects
#7
James Zou, Gregory Valiant, Paul Valiant, Konrad Karczewski, Siu On Chan, Kaitlin Samocha, Monkol Lek, Shamil Sunyaev, Mark Daly, Daniel G MacArthur
As new proposals aim to sequence ever larger collection of humans, it is critical to have a quantitative framework to evaluate the statistical power of these projects. We developed a new algorithm, UnseenEst, and applied it to the exomes of 60,706 individuals to estimate the frequency distribution of all protein-coding variants, including rare variants that have not been observed yet in the current cohorts. Our results quantified the number of new variants that we expect to identify as sequencing cohorts reach hundreds of thousands of individuals...
October 31, 2016: Nature Communications
https://www.readbyqxmd.com/read/27732794/regulation-and-role-of-fungal-secondary-metabolites
#8
Juliane Macheleidt, Derek J Mattern, Juliane Fischer, Tina Netzker, Jakob Weber, Volker Schroeckh, Vito Valiante, Axel A Brakhage
Fungi have the capability to produce a tremendous number of so-called secondary metabolites, which possess a multitude of functions, e.g., communication signals during coexistence with other microorganisms, virulence factors during pathogenic interactions with plants and animals, and in medical applications. Therefore, research on this topic has intensified significantly during the past 10 years and thus knowledge of regulatory mechanisms and the understanding of the role of secondary metabolites have drastically increased...
November 23, 2016: Annual Review of Genetics
https://www.readbyqxmd.com/read/27635231/recent-advances-in-targeted-therapy-for-ewing-sarcoma
#9
REVIEW
Kathleen I Pishas, Stephen L Lessnick
Ewing sarcoma is an aggressive, poorly differentiated neoplasm of solid bone that disproportionally afflicts the young. Despite intensive multi-modal therapy and valiant efforts, 70% of patients with relapsed and metastatic Ewing sarcoma will succumb to their disease. The persistent failure to improve overall survival for this subset of patients highlights the urgent need for rapid translation of novel therapeutic strategies. As Ewing sarcoma is associated with a paucity of mutations in readily targetable signal transduction pathways, targeting the key genetic aberration and master regulator of Ewing sarcoma, the EWS/ETS fusion, remains an important goal...
2016: F1000Research
https://www.readbyqxmd.com/read/27617281/quantitative-geospatial-dataset-on-the-near-surface-heavy-metal-concentrations-in-semi-arid-soils-from-maibele-airstrip-north-central-botswana
#10
Peter N Eze, Valiant S Mosokomani, Theophilus K Udeigwe, Opeoluwa F Oyedele
This article contains a statistically analyzed dataset of the heavy metals including Cr, Co, Ni, Cu, Zn and Pb contents of near-surface (~30 cm depth) soils in a Cu-Ni prospecting field at Airstrip North, Central Botswana. The soils developed on paragneisses and amphibolites parent materials in a semi-arid environment with hardveld vegetation, "The geology of the Topisi area" (Key et al., 1994) [1]. Grid sampling was adopted in the field data collection. Heavy metals were determined using the relatively new portable x-ray fluorescence spectrometer (Delta Premium, 510,890, USA) technology in a "soil" mode...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27611015/functional-reconstitution-of-a-fungal-natural-product-gene-cluster-by-advanced-genome-editing
#11
Jakob Weber, Vito Valiante, Christina Spuur Nødvig, Derek Joseph Mattern, Rebecca A Slotkowski, Uffe H Mortensen, Axel A Brakhage
Filamentous fungi produce varieties of natural products even in a strain dependent manner. However, the genetic basis of chemical speciation between strains is still widely unknown. One example is trypacidin, a natural product of the opportunistic human pathogen Aspergillus fumigatus, which is not produced amongst different isolates. Combining computational analysis with targeted gene editing, we could link a single nucleotide insertion in the polyketide synthase of the trypacidin biosynthetic pathway and reconstitute its production in a nonproducing strain...
September 9, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27609048/meningioangiomatosis-a-disease-with-many-radiological-faces
#12
Fábio A Nascimento, Tim-Rasmus Kiehl, Peter C Tai, Taufik A Valiante, Timo Krings
No abstract text is available yet for this article.
September 9, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27576185/closed-loop-interruption-of-hippocampal-ripples-through-fornix-stimulation-in-the-non-human-primate
#13
Omid Talakoub, Andrea Gomez Palacio Schjetnan, Taufik A Valiante, Milos R Popovic, Kari L Hoffman
BACKGROUND: Hippocampal sharp-wave ripples (SWRs) arising from synchronous bursting in CA3 pyramidal cells and propagating to CA1 are thought to facilitate memory consolidation. Stimulation of the CA3 axon collaterals comprising the hippocampal commissure in rats interrupts sharp-wave ripples and leads to memory impairment. In primates, however, these commissural collaterals are limited. Other hippocampal fiber pathways, like the fornix, may be potential targets for modulating ongoing hippocampal activity, with the short latencies necessary to interrupt ripples...
August 2, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27499801/an-improved-four-russians-method-and-sparsified-four-russians-algorithm-for-rna-folding
#14
Yelena Frid, Dan Gusfield
BACKGROUND: The basic RNA secondary structure prediction problem or single sequence folding problem (SSF) was solved 35 years ago by a now well-known [Formula: see text]-time dynamic programming method. Recently three methodologies-Valiant, Four-Russians, and Sparsification-have been applied to speedup RNA secondary structure prediction. The sparsification method exploits two properties of the input: the number of subsequence Z with the endpoints belonging to the optimal folding set and the maximum number base-pairs L...
2016: Algorithms for Molecular Biology: AMB
https://www.readbyqxmd.com/read/27464853/extracellular-potassium-and-seizures-excitation-inhibition-and-the-role-of-ih
#15
Lihua Wang, Suzie Dufour, Taufik A Valiante, Peter L Carlen
Seizure activity leads to increases in extracellular potassium concentration ([K[Formula: see text]]o), which can result in changes in neuronal passive and active membrane properties as well as in population activities. In this study, we examined how extracellular potassium modulates seizure activities using an acute 4-AP induced seizure model in the neocortex, both in vivo and in vitro. Moderately elevated [K[Formula: see text]]o up to 9[Formula: see text]mM prolonged seizure durations and shortened interictal intervals as well as depolarized the neuronal resting membrane potential (RMP)...
December 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/27439378/novel-adjuvant-alum-tlr7-significantly-potentiates-immune-response-to-glycoconjugate-vaccines
#16
Cecilia Buonsanti, Cristiana Balocchi, Carole Harfouche, Federica Corrente, Luisa Galli Stampino, Francesca Mancini, Marta Tontini, Padma Malyala, Simone Bufali, Barbara Baudner, Ennio De Gregorio, Nicholas M Valiante, Derek T O'Hagan, Rino Rappuoli, Ugo D'Oro
Although glycoconjugate vaccines are generally very efficacious, there is still a need to improve their efficacy, especially in eliciting a strong primary antibody response. We have recently described a new type of vaccine adjuvant based on a TLR7 agonist adsorbed to alum (Alum-TLR7), which is highly efficacious at enhancing immunogenicity of protein based vaccines. Since no adjuvant has been shown to potentiate the immune response to glycoconjugate vaccines in humans, we investigated if Alum-TLR7 is able to improve immunogenicity of this class of vaccines...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27393422/the-aspergillus-fumigatus-conidial-melanin-production-is-regulated-by-the-bifunctional-bhlh-devr-and-mads-box-rlma-transcription-factors
#17
Vito Valiante, Clara Baldin, Peter Hortschansky, Radhika Jain, Andreas Thywißen, Maria Straßburger, Ekaterina Shelest, Thorsten Heinekamp, Axel A Brakhage
Melanins play a crucial role in defending organisms against external stressors. In several pathogenic fungi, including the human pathogen Aspergillus fumigatus, melanin production was shown to contribute to virulence. A. fumigatus produces two different types of melanins, i.e., pyomelanin and dihydroxynaphthalene (DHN)-melanin. DHN-melanin forms the gray-green pigment characteristic for conidia, playing an important role in immune evasion of conidia and thus for fungal virulence. The DHN-melanin biosynthesis pathway is encoded by six genes organized in a cluster with the polyketide synthase gene pksP as a core element...
July 9, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27375547/restoration-of-upper-limb-function-in-an-individual-with-cervical-spondylotic-myelopathy-using-functional-electrical-stimulation-therapy-a-case-study
#18
Milos R Popovic, Vera Zivanovic, Taufik A Valiante
Non-traumatic spinal cord pathology is responsible for 25-52% of all spinal cord lesions. Studies have revealed that spinal stenosis accounts for 16-21% of spinal cord injury (SCI) admissions. Impaired grips as well as slow unskilled hand and finger movements are the most common complaints in patients with spinal cord disorders, such as myelopathy secondary to cervical spondylosis. In the past, our team carried out couple of successful clinical trials, including two randomized control trials, showing that functional electrical stimulation therapy (FEST) can restore voluntary reaching and/or grasping function, in people with stroke and traumatic SCI...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27353607/predicting-outcomes-over-time-in-patients-with-heart-failure-left-ventricular-systolic-dysfunction-or-both-following-acute-myocardial-infarction
#19
Renato D Lopes, Karen S Pieper, Susanna R Stevens, Scott D Solomon, John J V McMurray, Marc A Pfeffer, Jeffrey D Leimberger, Eric J Velazquez
BACKGROUND: Most studies of risk assessment or stratification in patients with myocardial infarction (MI) have been static and fail to account for the evolving nature of clinical events and care processes. We sought to identify predictors of mortality, cardiovascular death or nonfatal MI, and cardiovascular death or nonfatal heart failure (HF) over time in patients with HF, left ventricular systolic dysfunction, or both post-MI. METHODS AND RESULTS: Using data from the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial, we developed models to estimate the association between patient characteristics and the likelihood of experiencing an event from the time of a follow-up visit until the next visit...
June 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27270029/incorporation-of-phosphonate-into-benzonaphthyridine-toll-like-receptor-7-agonists-for-adsorption-to-aluminum-hydroxide
#20
Alex Cortez, Yongkai Li, Andrew T Miller, Xiaoyue Zhang, Kathy Yue, Jillian Maginnis, Janice Hampton, De Shon Hall, Michael Shapiro, Bishnu Nayak, Ugo D'Oro, Chun Li, David Skibinski, M Lamine Mbow, Manmohan Singh, Derek T O'Hagan, Michael P Cooke, Nicholas M Valiante, Tom Y-H Wu
Small molecule Toll-like receptor 7 (TLR7) agonists have been used as vaccine adjuvants by enhancing innate immune activation to afford better adaptive response. Localized TLR7 agonists without systemic exposure can afford good adjuvanticity, suggesting peripheral innate activation (non-antigen-specific) is not required for immune priming. To enhance colocalization of antigen and adjuvant, benzonaphthyridine (BZN) TLR7 agonists are chemically modified with phosphonates to allow adsorption onto aluminum hydroxide (alum), a formulation commonly used in vaccines for antigen stabilization and injection site deposition...
June 23, 2016: Journal of Medicinal Chemistry
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