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Pold3 and mitosis

Sheroy Minocherhomji, Songmin Ying, Victoria A Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W Mankouri, Huahao Shen, Ying Liu, Ian D Hickson
Oncogene-induced DNA replication stress has been implicated as a driver of tumorigenesis. Many chromosomal rearrangements characteristic of human cancers originate from specific regions of the genome called common fragile sites (CFSs). CFSs are difficult-to-replicate loci that manifest as gaps or breaks on metaphase chromosomes (termed CFS 'expression'), particularly when cells have been exposed to replicative stress. The MUS81-EME1 structure-specific endonuclease promotes the appearance of chromosome gaps or breaks at CFSs following replicative stress...
December 10, 2015: Nature
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