Wei Wu, Rahul Bhowmick, Ivan Vogel, Özgün Özer, Fiorella Ghisays, Roshan S Thakur, Esther Sanchez de Leon, Philipp H Richter, Liqun Ren, John H Petrini, Ian D Hickson, Ying Liu
Oncogene activation during tumorigenesis generates DNA replication stress, a known driver of genome rearrangements. In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and subsequently complete locus duplication in mitosis in a process known as 'MiDAS'. Here, we demonstrate that RTEL1 (regulator of telomere elongation helicase 1) has a genome-wide role in MiDAS at loci prone to form G-quadruplex-associated R-loops, in a process that is dependent on its helicase function...
May 2020: Nature Structural & Molecular Biology