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https://www.readbyqxmd.com/read/28319809/abt-737-synergizes-with-cisplatin-bypassing-aberration-of-apoptotic-pathway-in-non-small-cell-lung-cancer
#1
Eun Young Kim, Ji Ye Jung, Arum Kim, Yoon Soo Chang, Se Kyu Kim
A subset of non-small cell lung cancer (NSCLC), which does not have a druggable driver mutation, is treated with platinum-based cytotoxic chemotherapy, but it develops resistance triggered by DNA damage responses. Here, we investigated the effect of activation of STAT3 by cisplatin on anti-apoptotic proteins and the effectiveness of a co-treatment with cisplatin and a BH3 mimetic, ABT-737. We analyzed the relationship between cisplatin and STAT3 pathway and effect of ABT-737, when combined with cisplatin in NSCLC cells and K-ras mutant mouse models...
March 17, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28317753/bioactive-amines-and-phenolic-compounds-in-cocoa-beans-are-affected-by-fermentation
#2
Brenda de Nazaré do Carmo Brito, Renan Campos Chisté, Rosinelson da Silva Pena, Maria Beatriz Abreu Gloria, Alessandra Santos Lopes
Cocoa is the target of increased scientific research as it is one of the richest source of bioactive compounds. The formation of bioactive amines and their changes in cocoa beans during seven days of traditional fermentation was investigated for the first time. In addition, total phenolic compounds, anthocyanins contents and the scavenging capacity against ABTS radical were determined to monitor the fermentation process. Only two biogenic amines (tryptamine and tyramine) and two polyamines (spermidine and spermine) were detected in cocoa beans during fermentation...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317750/effects-of-storage-time-and-temperature-on-lipid-oxidation-of-egg-powders-enriched-with-natural-antioxidants
#3
Paula Toshimi Matumoto-Pintro, Alice Eiko Murakami, Ana Carolina Pelaes Vital, Camila Croge, Denise Felix da Silva, Ivan Camilo Ospina-Roja, Ana Flávia Quiles Garcia Guerra
The lipid fraction of egg powder may be affected by storage conditions due to the development of oxidative rancidity caused by polyunsaturated fatty acids. This study evaluated egg powders enriched with antioxidants [tocopherol, catechin, lycopene, and butylated hydroxyanisole (BHA)] for conjugated dienes (during a 90-day period) and for malonaldehydes (during a 210-day period) at 25±2 and 4±1°C. The presence of lycopene and BHA increases the total phenolic compounds in the enriched egg powders, and BHA exhibits the most antioxidant activity, as quantified by an ABTS assay...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317745/the-impact-of-rhizopus-oryzae-cultivation-on-rice-bran-gamma-oryzanol-recovery-and-its-antioxidant-properties
#4
Kelly Cristina Massarolo, Taiana Denardi de Souza, Carolina Carvalho Collazzo, Eliana Badiale Furlong, Leonor Almeida de Souza Soares
This study evaluated the effect of the solid state cultivation (SSC) time of rice bran by Rhizopus oryzae on γ-oryzanol recovery and its antioxidant properties. Gamma-oryzanol was extracted with organic solvents and its extracts were characterized by GC-FID and HPLC-UV. The antioxidant capacity was assessed by DPPH and ABTS(+) assays, β-carotene/linoleic acid system, and reduction of oxidation in lipid system. The biomass showed the γ-oryzanol recovery increased by 51.5% (20.52mg/g), and 5.7% in polyunsaturated fatty acids...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317712/lc-esi-qtof-ms-identification-of-novel-antioxidant-peptides-obtained-by-enzymatic-and-microbial-hydrolysis-of-vegetable-proteins
#5
Elena Babini, Davide Tagliazucchi, Serena Martini, Lucilla Dei Più, Andrea Gianotti
Bioactive antioxidant peptides are more and more attracting the attention of food manufacturers for their potential to transform food in functional food, able to prevent a variety of chronic diseases associated with oxidative stress. In the present study proteins extracted from different vegetable sources (KAMUT® khorasan wheat, emmer, lupine and pea) were hydrolyzed with commercial enzymes and Lactobacillus spp. strains. Hydrolysates were separated by size exclusion chromatography and purified fractions were analyzed for their antioxidant activity...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317705/comparison-of-old-cherry-cultivars-grown-in-czech-republic-by-chemical-composition-and-bioactive-compounds
#6
Agnieszka Nawirska-Olszańska, Joanna Kolniak-Ostek, Maciej Oziembłowski, Alena Ticha, Radomir Hyšpler, Zdenek Zadak, Pavla Židová, Frantisek Paprstein
Sweet cherry fruits are readily consumed by humans, and they contain significant quantities of bioactive compounds. Fifteen sweet cherry (Prunus avium L.) old cultivars grown in the Czech Republic were examined. In fresh fruits the contents of sugars, organic acids, and phenolic compounds, and antioxidant capacity were determined. The analyses showed that the fruits of sweet cherry are characterized by high contents of bioactive compounds. Four organic acids - malic, quinic, shikimic, and fumaric acid - were determined in examined fruits...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28314386/veliparib-in-combination-with-radiotherapy-for-the-treatment-of-mgmt-unmethylated-glioblastoma
#7
Toni Rose Jue, Kyoko Nozue, Ashleigh J Lester, Swapna Joshi, Lisette B W Schroder, Shane P Whittaker, Sheri Nixdorf, Robert W Rapkins, Mustafa Khasraw, Kerrie L McDonald
BACKGROUND: The O (6) -methylguanine methyltransferase (MGMT) gene is frequently unmethylated in patients with glioblastoma (GBM), rendering them non-responsive to the standard treatment regime of surgery followed by concurrent radiotherapy (RT) and temozolomide. Here, we investigate the efficacy of adding a PARP inhibitor, veliparib, to radiotherapy to treat MGMT unmethylated GBM. METHODS: The inhibition of PARP with veliparib (ABT-888), a potent and orally bioavailable inhibitor in combination with RT was tested on a panel of patient derived cell lines (PDCLs) and patient-derived xenografts (PDX) models generated from GBM patients with MGMT unmethylated tumors...
March 17, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28306529/in-vitro-inhibition-of-phosphodiesterase-5-and-arginase-activities-from-rat-penile-tissue-by-two-nigerian-herbs-hunteria-umbellata-and-anogeissus-leiocarpus
#8
Ganiyu Oboh, Adeniyi Abiodun Adebayo, Ayokunle Olubode Ademosun, Aline August Boligon
BACKGROUND: Anogeissus leiocarpus and Hunteria umbellata have been reportedly used in traditional medicine for the management of erectile dysfunction (ED). However, the scientific basis for their use has not been well established. Therefore, this study was designed to investigate the inhibitory effects of water extractable phytochemicals of H. umbellata and A. leiocarpus on phosphodiesterase-5 (PDE-5) and arginase as well as pro-oxidants induced lipid peroxidation in rat penile tissue...
March 17, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28306206/phytochemical-profile-and-biological-activities-of-helianthemum-canum-from-turkey
#9
Ayşe Baldemir, Neslihan Gökşen, Nilay Ildız, Gökçe Şeker Karatoprak, Müberra Koşar
In the current study, antioxidant, antibacterial activities, and the phenolic compositions of extracts from Helianthemum canum L. Baumg (Apiaceae) aerial parts were investigated for the first time. The H. canum was extracted with 70% methanol (HCMeOH) and water (HCW). Both extracts were determined by total phenolic contents (3 mg/mL), flavonoids (1.5 mg/mL), flavonols (1.5 mg/mL), qualitative-quantitative compositions, iron (II) chelation activities (0.1-5 mg/mL), free radical scavenging activities (DPPH(●) : 0...
March 17, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28303540/exploiting-fruit-byproducts-for-eco-friendly-nanosynthesis-citrus%C3%A2-%C3%A3-%C3%A2-clementina-peel-extract-mediated-fabrication-of-silver-nanoparticles-with-high-efficacy-against-microbial-pathogens-and-rat-glial-tumor-c6-cells
#10
Rijuta Ganesh Saratale, Han-Seung Shin, Gopalakrishnan Kumar, Giovanni Benelli, Gajanan S Ghodake, Yuan Yuan Jiang, Dong Su Kim, Ganesh Dattatraya Saratale
Process byproducts from the fruit industry may represent a cheap and reliable source of green reducing agents to be used in current bio-nanosynthesis. This study reports the use of orange (Citrus × clementina) peel aqueous extract (OPE) for one-pot green synthesis of silver nanoparticles (AgNPs) with high effectiveness against various microbial pathogens as well as rat glial tumor C6 cells. The effects of various operational parameters on the synthesis of AgNPs were systematically investigated. The morphology, particle size, and properties of synthesized AgNPs were characterized using UV-visible spectroscopy, x-ray diffraction, x-ray photoelectron spectroscopy, field emission scanning electron microscopy, energy-dispersive x-ray spectroscopy, and Fourier transform infrared spectroscopy...
March 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28302970/modified-radical-scavenging-and-antioxidant-activity-measurement-of-%C3%AE-carotene-with-%C3%AE-cyclodextrins-complexation-in-aqueous-medium
#11
Saliha Esin Çelik, Burcu Bekdeser, Ayse Nur Tufan, Resat Apak
In order to evaluate the antioxidant capacity/activity of β-carotene (BC) in aqueous media, we investigated the inclusion complexes of BC with methyl-β-cyclodextrin (Me-β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and 2-hydroxyethyl-β-cyclodextrin (HE-β-CD) that enhance water solubility and chemical stability. The inclusion complexes (monitored by FTIR) exhibited higher solubility than free BC, and phase solubility studies showed a linear increase in the solubility with the Me-β-CD concentration...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28301958/unlocking-the-in-vitro-anti-inflammatory-and-antidiabetic-potential-of-polygonum-maritimum
#12
Maria João Rodrigues, Luísa Custódio, Andreia Lopes, Marta Oliveira, Nuno R Neng, José M F Nogueira, Alice Martins, Amélia P Rauter, João Varela, Luísa Barreira
CONTEXT: Several Polygonum species (Polygonaceae) are used in traditional medicine in Asia, Europe and Africa to treat inflammation and diabetes. OBJECTIVE: Evaluate the in vitro antioxidant, anti-inflammatory and antidiabetic potential of methanol and dichloromethane extracts of leaves and roots of the halophyte Polygonum maritimum L. MATERIAL AND METHODS: Antioxidant activity was determined (up to 1 mg/mL) as radical-scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), copper (CCA) and iron (ICA) chelating activities and iron reducing power (FRAP)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28294059/phytochemical-screening-alpha-glucosidase-inhibition-antibacterial-and-antioxidant-potential-of-ajuga-bracteosa-extracts
#13
Kokab Hafeez, Saiqa Andleeb, Tahseen Ghousa, Kalsoom Akhter
BACKGROUND: Ajuga bracteosa, a medicinal herb, used by local community to cure a number of diseases such as inflammation, jaundice bronchial asthma, cancer and diabetes. OBJECTIVES: The aim of present work was to evaluate the antioxidant potential, in vitro antidiabetic and antimicrobial effects of A. bracteosa. METHODS: n-hexane, ethyl acetate, chloroform, acetone, methanol and aqueous extracts of Ajuga bracteosa roots, were prepared via maceration...
March 12, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28293470/hypothalamic-pituitary-adrenal-axis-and-depression-symptom-effects-of-an-arginine-vasopressin-type-1b-receptor-antagonist-in-a-one-week-randomized-phase-1b-trial
#14
David A Katz, Charles Locke, Nicholas Greco, Wei Liu, Katherine A Tracy
BACKGROUND: Arginine vasopressin 1B receptor (V1B) antagonists may have utility for the treatment of major depressive disorder (MDD). METHODS: The V1B antagonist ABT-436 (N = 31) or matching placebo (N = 20) was administered to MDD subjects for 7 days. The main study objectives were to assess the safety and hypothalamic-pituitary-adrenal axis (HPA) effects of ABT-436 in MDD subjects. MDD symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAM-D-17) and the subject-rated Mood and Anxiety Symptom Questionnaire (MASQ)...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28289386/traditionally-used-lathyrus-species-phytochemical-composition-antioxidant-activity-enzyme-inhibitory-properties-cytotoxic-effects-and-in-silico-studies-of-l-czeczottianus-and-l-nissolia
#15
Eulogio J Llorent-Martínez, Gokhan Zengin, María L Fernández-de Córdova, Onur Bender, Arzu Atalay, Ramazan Ceylan, Adriano Mollica, Andrei Mocan, Sengul Uysal, Gokalp O Guler, Abdurrahman Aktumsek
Members of the genus Lathyrus are used as food and as traditional medicines. In order to find new sources of biologically-active compounds, chemical and biological profiles of two Lathyrus species (L. czeczottianus and L. nissolia) were investigated. Chemical profiles were evaluated by HPLC-ESI-MS(n), as well as by their total phenolic and flavonoid contents. In addition, antioxidant, enzyme inhibitory, and cytotoxic effects were also investigated. Antioxidant properties were tested by using different assays (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelation)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28288834/exception-points-and-body-size-contribute-to-gender-disparity-in-liver-transplantation
#16
Lauren D Nephew, David Goldberg, James D Lewis, Peter Abt, Mathew Bryan, Kimberly A Forde
BACKGROUND & AIMS: Women are significantly less likely than men to receive a liver transplant and more likely to die on the waitlist. We investigated potential reasons for these disparities, including match run positions and declined organs due to small stature of female recipients. METHODS: We analyzed data from the United Network of Organ Sharing registry of candidates placed on the waitlist from May 10, 2007 through June 17, 2013. Primary outcomes included: ranked in first position on a match run, having an organ declined while in first position, declining an organ while in first position because of size mismatch between donor and recipient (body surface area discordance), and death or becoming too sick for liver transplantation...
March 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28288819/multifaceted-anticancer-activity-of-bh3-mimetics-current-evidence-and-future-prospects
#17
REVIEW
Małgorzata Opydo-Chanek, Oscar Gonzalo, Isabel Marzo
BH3 mimetics are a novel class of anticancer agents designed to specifically target pro-survival proteins of the Bcl-2 family. Like endogenous BH3-only proteins, BH3 mimetics competitively bind to surface hydrophobic grooves of pro-survival Bcl-2 family members, counteracting their protective effects and thus facilitating apoptosis in cancer cells. Among the small-molecule BH3 mimetics identified, ABT-737 and its analogs, obatoclax as well as gossypol derivatives are the best characterized. The anticancer potential of these compounds applied as a single agent or in combination with chemotherapeutic drugs is currently being evaluated in preclinical studies and in clinical trials...
March 10, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28284335/oxidative-modifications-of-blood-serum-proteins-in-myasthenia-gravis
#18
Monika Adamczyk-Sowa, Edyta Bieszczad-Bedrejczuk, Sabina Galiniak, Izabela Rozmiłowska, Damian Czyżewski, Grzegorz Bartosz, Izabela Sadowska-Bartosz
Myasthenia gravis (MG) is an autoimmune disease caused by production of antibodies against acetylcholine receptors of the neuromuscular junction (Ab). The aim of this study was to ascertain if oxidative stress accompanies MG by estimation of the several independent parameters of oxidative damage, mainly the levels of oxidative modifications of blood serum proteins. The group studied consisted of 50 MG patients (28 females and 22 males), 24 with ocular MG (OMG) and 26 with generalized MG (GMG), of mean age of 66...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28284312/combined-cross-linked-enzyme-aggregates-of-horseradish-peroxidase-and-glucose-oxidase-for-catalyzing-cascade-chemical-reactions
#19
Le Truc Nguyen, Kun-Lin Yang
Cascade reactions involved unstable intermediates are often encountered in biological systems. In this study, we developed combined cross-linked enzyme aggregates (combi-CLEA) to catalyze a cascade reaction which involves unstable hydrogen peroxide as an intermediate. The combi-CLEA contains two enzymes̶ glucose oxidase (GOx) and horseradish peroxidase (HRP) which are cross-linked together as solid aggregates. The first enzyme GOx catalyzes the oxidation of glucose and produces hydrogen peroxide, which is used by the second enzyme HRP to oxidize 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS)...
May 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28279820/binding-affinity-of-pro-apoptotic-bh3-peptides-for-the-anti-apoptotic-mcl-1-and-a1-proteins-molecular-dynamics-simulations-of-mcl-1-and-a1-in-complex-with-six-different-bh3-peptides
#20
Vivek Modi, Ramasubbu Sankararamakrishnan
The anti-apoptotic members of Bcl-2 family of proteins bind to their pro-apoptotic counterparts to induce or prevent cell death.Based on the distinct binding profiles for specific pro-apoptotic BH3 peptides, the anti-apoptotic Bcl-2 proteins can be divided into at least two subclasses. The subclass that includes Bcl-XL binds strongly to Bad BH3 peptide while it has weak binding affinity for the second subclass of Bcl-2 proteins such as Mcl-1 and A1. Anti-apoptotic Bcl-2 proteins are considered to be attractive drug targets for anti-cancer drugs...
February 9, 2017: Journal of Molecular Graphics & Modelling
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