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https://www.readbyqxmd.com/read/28723622/dual-targeting-of-mdm2-and-bcl2-as-a-therapeutic-strategy-in-neuroblastoma
#1
Alan Van Goethem, Nurten Yigit, Myrthala Moreno-Smith, Sanjeev A Vasudevan, Eveline Barbieri, Frank Speleman, Jason Shohet, Jo Vandesompele, Tom Van Maerken
Wild-type p53 tumor suppressor activity in neuroblastoma tumors is hampered by increased MDM2 activity, making selective MDM2 antagonists an attractive therapeutic strategy for this childhood malignancy. Since monotherapy in cancer is generally not providing long-lasting clinical responses, we here aimed to identify small molecule drugs that synergize with idasanutlin (RG7388). To this purpose we evaluated 15 targeted drugs in combination with idasanutlin in three p53 wild type neuroblastoma cell lines and identified the BCL2 inhibitor venetoclax (ABT-199) as a promising interaction partner...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721816/plga-nanoparticles-and-polysorbate-80-coated-plga-nanoparticles-increase-in-the-vitro-antioxiant-activity-of-melatonin
#2
Leiziani Gnatkowski Martins, Najeh Maissar Khalil, Rubiana Mara Mainardes
Melatonin is an endogen substance with several physiological functions, acting as an important antioxidant. Our objective was to prepare nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) coated with polysorbate 80 (PLGA-PS80) or uncoated (PLGA) nanoparticles containing melatonin (MLT) and evaluate their in vitro cytotoxicity over erythrocytes and in vitro antioxidant activity. Nanoparticles were obtained by an emulsion-solvent evaporation method and characterized by size, morphology, polydispersity index, zeta potential, encapsulation efficiency, thermal properties and in vitro drug release profile...
July 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28720952/anthocyanins-enriched-purple-tea-exhibits-antioxidant-immunostimulatory-and-anticancer-activities
#3
Robin Joshi, Ajay Rana, Vinay Kumar, Dharmesh Kumar, Yogendra S Padwad, Sudesh Kumar Yadav, Ashu Gulati
Purple coloured tea shoot clones have gained interest due to high content of anthocyanins in addition to catechins. Transcript expression of genes encoding anthocyanidin reductase (ANR), dihydroflavonol-4-reductase (DFR), anthocyanidin synthase (ANS), flavonol synthase (FLS) and leucoantho cyanidin reductase (LAR) enzymes in three new purple shoot tea clones compared with normal tea clone showed higher expression of CsDFR, CsANR, CsANS and lower expression of CsFLS and CsLAR in purple shoot clones compared to normal clone...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720944/evaluation-of-the-chemical-composition-antioxidant-and-anti-inflammatory-activities-of-distillate-and-residue-fractions-of-sweet-basil-essential-oil
#4
Hailong Li, Yanhui Ge, Zhimin Luo, Yulan Zhou, Xuguang Zhang, Junqing Zhang, Qiang Fu
In this study, the chemical composition and antioxidant and anti-inflammatory activities of sweet basil (Ocimum basilicum L. Lamiaceae family) were evaluated. Sweet basil is a food-related plant that is widely used in traditional Chinese medicine. Sweet basil crude oil was processed via molecular distillation and further characterized using gas chromatography-mass spectrometry (GC-MS) to screen for new compounds. The GC-MS analysis identified thirty-eight compounds. The major constituents of the residue fraction were estragole (17...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720929/antioxidant-characteristics-of-extracts-of-hibiscus-sabdariffa-calyces-encapsulated-with-mesquite-gum
#5
C E Ochoa-Velasco, C Salazar-González, S Cid-Ortega, J A Guerrero-Beltrán
This study compared the stability of extracts of H. sabdariffa calyces microencapsulated with different concentrations of mesquite gum during storage. Dry Roselle calyces were mixed with 50:50 (v/v) ethanol:water solution to obtain 18°Bx concentrate. This Roselle extract concentrate was mixed with purified mesquite gum (100:1-100:5 v/w). The Roselle extract concentrate-gum (RECG) was spray dried at inlet and outlet temperatures of 180 ± 2 and 104 ± 2.3 °C, respectively, at an air flow rate of 38 m(3)/h...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28718789/flavonoid-and-antioxidant-capacity-of-propolis-prediction-using-near-infrared-spectroscopy
#6
Eddy Betances-Salcedo, Isabel Revilla, Ana M Vivar-Quintana, M Inmaculada González-Martín
The use of propolis as a dietary supplement or as an ingredient in different food products is increasing, due to its antioxidant and bactericidal properties. These nutritional properties directly depend on its phenolic composition. For this reason, this study analysed the total contents of flavones and flavonols, flavanones and dihydroflavonols, and the antioxidant capacity by using the methods of ABTS and linoleic acid/β-carotene in 99 samples of propolis from Spain and Chile. A rapid method was developed for quantifying these parameters in raw propolis using near infrared (NIR) spectroscopy with a remote reflectance fibre-optic probe applied directly to the ground-up sample...
July 18, 2017: Sensors
https://www.readbyqxmd.com/read/28715604/antioxidant-activities-and-phenolic-compounds-of-several-tissues-of-pawpaw-asimina-triloba-l-dunal-grown-in-korea
#7
Jin-Sik Nam, Hye-Lim Jang, Young Ha Rhee
Pawpaw (Asimina triloba [L.] Dunal) possesses antioxidant compounds and strong inhibitors of cancer cells, and is widely cultivated in North America, Canada, and Korea. We analyzed the total phenolic and total flavonoid contents (TPC and TFC, respectively) of pawpaw plants grown in Korea and the antioxidant activities of their roots, twigs, leaves, and fruit with respect to 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis diammonium salt (ABTS) radical scavenging activity, ferrous (Fe(2+) ) chelating ability, and nitrite scavenging activity...
July 17, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28714899/electrochemical-flow-elisa-for-rapid-and-sensitive-determination-of-microcystin-lr-using-automated-sequential-injection-system
#8
Lesedi Lebogang, Jongjit Jantra, Martin Hedström, Bo Mattiasson
An amperometric immunoanalysis system based on monoclonal antibodies immobilized on Sepharose beads and packed into a micro-immunocolumn was developed for the quantification of microcystin-LR. Microcystin-LR (MCLR) was used as a reference microcystin variant. Inside the immunocolumn, free microcystins and microcystin-horseradish peroxidase (tracer) were sequentially captured by the immobilized antibodies, and the detection was performed electrochemically using Super AquaBlue ELISA substrate 2,2'-azinobis(3-ethylbenzothiazoline-sulfonic acid) (ABTS)...
July 16, 2017: Sensors
https://www.readbyqxmd.com/read/28714472/targeting-the-differential-addiction-to-anti-apoptotic-bcl-2-family-for-cancer-therapy
#9
Akane Inoue-Yamauchi, Paul S Jeng, Kwanghee Kim, Hui-Chen Chen, Song Han, Yogesh Tengarai Ganesan, Kota Ishizawa, Sylvia Jebiwott, Yiyu Dong, Maria C Pietanza, Matthew D Hellmann, Mark G Kris, James J Hsieh, Emily H Cheng
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-XL or MCL-1, which correlated with the respective protein expression ratio. ABT-263 (navitoclax), a BCL-2/BCL-XL inhibitor, prevented BCL-XL from sequestering activator BH3-only molecules (BH3s) and BAX but not BAK. Consequently, ABT-263 failed to kill BCL-XL-addicted cells with low activator BH3s and BCL-XL overabundance conferred resistance to ABT-263...
July 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28714345/chemical-composition-and-antioxidant-activity-of-aerial-parts-of-ferula-longipes-coss-ex-bonnier-and-maury
#10
Aicha Bouratoua, Assia Khalfallah, Chawki Bensouici, Zahia Kabouche, Abdulmagid Alabdul Magid, Dominique Harakat, Laurence Voutquenne-Nazabadioko, Ahmed Kabouche
This is the first study on the phytochemistry and antioxidant activity of Ferula longipes Coss. ex Bonnier and Maury (Apiaceae). A new flavonoid quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-[2-O-caffeoyl]-glucopyranoside (1), along with 10 known compounds kaempferol-3-O-α-L-rhamnopyranoside (2), quercetin-3-O-α-L-rhamnopyranoside (3), kaempferol-3-O-ß-D-glucopyranoside-7-O-α-L-rhamnopyranoside (4), isorhamnetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (5), quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (6), isorhamnetin-3,7-di-O-β-D-glucopyranoside (7), apigenin (8), apigenin-7-O-ß-D-glucopyranoside (9), 3,5-dicaffeoylquinic acid (10), deltoin (11) were isolated from the aerial parts of Ferula longipes Coss...
July 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28713162/abt-263-induces-g1-g0-phase-arrest-apoptosis-and-autophagy-in-human-esophageal-cancer-cells-in-vitro
#11
Qing-Huan Lin, Fu-Chang Que, Chun-Ping Gu, De-Sheng Zhong, Dan Zhou, Yi Kong, Le Yu, Shu-Wen Liu
Both the anti- and pro-apoptotic members of the Bcl-2 family are regulated by a conserved Bcl-2 homology (BH3) domain. ABT-263 (Navitoclax), a novel BH3 mimetic and orally bioavailable Bcl-2 family inhibitor with high affinity for Bcl-xL, Bcl-2 and Bcl-w has entered clinical trials for cancer treatment. But the anticancer mechanisms of ABT-263 have not been fully elucidated. In this study we investigated the effects of ABT-263 on human esophageal cancer cells in vitro and to explore its anticancer mechanisms...
July 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28712306/targeting-intrinsic-apoptosis-and-other-forms-of-cell-death-by-bh3-mimetics-in-glioblastoma
#12
Georg Karpel-Massler, Chiaki Tsuge Ishida, Yiru Zhang, Marc-Eric Halatsch, M-Andrew Westhoff, Markus D Siegelin
Novel approaches to treat malignant brain tumors are necessary since these neoplasms still display an unfavorable prognosis. Areas covered: In this review, the authors summarize and analyze recent preclinical data that suggest that targeting intrinsic apoptosis may be a suitable strategy for the treatment of malignant gliomas. They focus on the anti-apoptotic Bcl-2 family members of proteins and the recent drug developments in that field with a special focus on BH3-mimetics. With the discovery of BH3-mimetics that interfere with anti-apoptotic Bcl-2 family members in the low nanomolar range significant excitement has been generated towards these class of inhibitors, such as ABT-737, ABT-263 and the most recent successor, ABT-199 which is most advanced with respect to clinical application...
July 17, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28704976/role-of-the-p-coumaroyl-moiety-in-the-antioxidant-and-cytoprotective-effects-of-flavonoid-glycosides-comparison-of-astragalin-and-tiliroside
#13
Xican Li, Yage Tian, Tingting Wang, Qiaoqi Lin, Xiaoyi Feng, Qian Jiang, Yamei Liu, Dongfeng Chen
The aim of this study was to explore the role of p-coumaroyl in the antioxidant and cytoprotective effects of flavonoid glycosides. The antioxidant effects of astragalin and tiliroside were compared using ferric ion reducing antioxidant power, DPPH• scavenging, ABTS•⁺ scavenging, •O₂(-) scavenging, and Fe(2+)-chelating assays. The results of these assays revealed that astragalin and tiliroside both exhibited dose-dependent activities; however, tiliroside exhibited lower IC50 values than astragalin...
July 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28702643/antioxidant-ace-inhibitory-and-antimicrobial-activity-of-fermented-goat-milk-activity-and-physicochemical-property-relationship-of-the-peptide-components
#14
Miriam Moreno-Montoro, Manuel Olalla-Herrera, José Ángel Rufián-Henares, Rafael Giménez Martínez, Beatriz Miralles, Triana Bergillos, Miguel Navarro-Alarcón, Paula Jauregi
Increasing evidence on goat milk and the health benefits of its derived products beyond its nutritional value show its potential as a functional food. In this study, goat milk fractions were tested for their total antioxidant capacity using different methods (ORAC, ABTS, DPPH and FRAP), as well as their angiotensin-I-converting-enzyme inhibitory and antimicrobial (against Escherichia coli and Micrococcus luteus) activities. Different whey fractions (whey, cation exchange membrane permeate P and retentate R) of two fermented skimmed goat milks (ultrafiltered goat milk fermented with the classical starter bacteria or with the classical starter plus the Lactobacillus plantarum C4 probiotic strain) were assessed...
July 13, 2017: Food & Function
https://www.readbyqxmd.com/read/28702427/antioxidant-and-anticholinesterase-potential-of-two-nigerian-bitter-yams-using-a-simulated-gastrointestinal-digestion-model-and-conventional-extraction
#15
Sule Ola Salawu, Praise Blessing Ajiboye, Akintunde Afolabi Akindahunsi, Aline Augusti Boligon
The purpose of this study was to evaluate the antioxidant and anticholinesterase activities of yellow and white bitter yams from South Western Nigeria using methanolic extraction and simulated gastrointestinal digestion models. The phenolic compounds in the bitter yam varieties were evaluated by high performance liquid chromatography with a diode array detector (HPLC-DAD). The total phenolic content of the bitter yams was measured by the Folin-Ciocalteu method, reductive potential by assessing the ability of the bitter yam to reduce FeCl3 solution, and the antioxidant activities were determined by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(·)) scavenging activity, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(·+)) scavenging activity, nitric oxide radical (NO(·)) scavenging ability, hydroxyl radical scavenging ability, and ability to inhibit Fe(2+)-induced lipid oxidation...
June 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28700017/plasma-total-antioxidant-capacity-and-cardiometabolic-risk-in-non-obese-and-clinically-healthy-young-adults
#16
Jamille Oliveira Costa, Cecília M Passos Vásquez, Gleiciane de Jesus Santana, Natanael de Jesus Silva, Juciene de Matos Braz, Amélia M Ribeiro de Jesus, Danielle Góes da Silva, Luana Celina Seraphim Cunha, Kiriaque Barra Ferreira Barbosa
Background: The oxidative biomarkers play an important role in the genesis of cardiometabolic risk-related processes. Objective: To investigate the total antioxidant capacity of plasma and its association with cardiometabolic risk in non-obese and clinically healthy young adults. Methods: University students of the state of Sergipe, Brazil, aged between 18 and 25 years, were recruited for this study from May of 2013 and October of 2014. Anthropometric, clinical and biochemical parameters were measured and analyzed using protocols which were previously standardized and described in the literature...
July 10, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28699753/identification-of-anthocyanins-from-four-kinds-of-berries-and-their-inhibition-activity-to-%C3%AE-glycosidase-and-protein-tyrosine-phosphatase-1b-by-hplc-ft-icr-ms-ms
#17
Ting Xiao, Zhenghong Guo, Baoshan Sun, Yuqing Zhao
The polyphenolic profiles of four berries (blueberry, bilberry, mulberry, and cranberry) in China were investigated using Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). Thirty-nine polyphenols including 26 anthocyanins, 9 flavonoids, and 4 phenolic acids were identified accurately. Cyanidin aglycones are common in four berries, and malvidin aglycones are the main compounds found in bilberry and cranberry. The anthocyanin level in blueberry are the highest with 739.6 ± 17.14 mg/g DW and presented the strongest antioxidant capacity in DPPH, ABTS, FRAP, and ORAC assay...
July 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28699489/synthesis-and-evaluation-of-antioxidant-and-cytotoxicity-of-the-n-mannich-base-of-berberine-bearing-benzothiazole-moieties
#18
Bhupendra M Mistry, Young-Soo Keum, Muthuraman Pandurangan, Doo Hwan Kim, So Hyun Moon, Avinash A Kadam, Surendra Shinde, Han-Seung Shin, Rahul V Patel
The N-Mannich base of an isoquinoline alkaloid, berberine, bearing substituted benzothiazole moieties was obtained. Novel synthesized analogues were in vitro screened for antioxidant efficacy toward 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radicals and in vitro cytotoxicity towards cervical cancer cell lines (HeLa and CaSki), an ovarian cancer cell line (SK-OV-3) and human renal cancer cell line (Caki-2). Cytotoxicity of the compounds toward normal cell lines was examined using the Madin-Darby canine kidney (MDCK) non-cancer cell line...
July 10, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28699009/bio-fabrication-of-silver-nanoparticles-using-the-leaf-extract-of-an-ancient-herbal-medicine-dandelion-taraxacum-officinale-evaluation-of-their-antioxidant-anticancer-potential-and-antimicrobial-activity-against-phytopathogens
#19
Rijuta G Saratale, Giovanni Benelli, Gopalakrishnan Kumar, Dong Su Kim, Ganesh D Saratale
In recent years, the use of nanoparticle-based antimicrobials has been increased due to many advantages over conventional agrochemicals. This study investigates the utilization of common medicinal plant dandelion, Taraxacum officinale, for the synthesis of silver nanoparticles (TOL-AgNPs). AgNPs were evaluated for antimicrobial activity against two important phytopathogens, Xanthomonas axonopodis and Pseudomonas syringae. The morphology, size, and structure of TOL-AgNPs were characterized using UV-visible spectroscopy and X-ray diffraction (XRD)...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28698451/phenolics-from-mikania-micrantha-and-their-antioxidant-activity
#20
Li-Mei Dong, Xu-Chao Jia, Qing-Wen Luo, Qiang Zhang, Bi Luo, Wen-Bin Liu, Xu Zhang, Qiao-Lin Xu, Jian-Wen Tan
A phytochemical study on the aerial parts of Mikania micrantha led to the isolation of two new phenolic compounds, benzyl 5-O-β-d-glucopyranosyl-2,5-dihydroxybenzoate (1) and (7S,8R)-threo-dihydroxydehydrodiconiferyl alcohol 9-acetate (2), together with twelve known compounds, benzyl 2-O-β-d-glucopyranosyl-2,6-dihydroxybenzoate (3), 4-allyl-2,6-dimethoxyphenol glucoside (4), (+)-isolariciresinol (5), icariol A₂ (6), 9,10-dihydroxythymol (7), 8,9,10-trihydroxythymol (8), caffeic acid (9), p-coumaric acid (10), ethyl protocatechuate (11), procatechuic aldehyde (12), 4-hydroxybenzoic acid (13), and hydroquinone (14)...
July 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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