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caffeine, brain development

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https://www.readbyqxmd.com/read/28643232/caffeine-protects-against-anticonvulsant-induced-neurotoxicity-in-the-developing-rat-brain
#1
Stefanie Endesfelder, Ulrike Weichelt, Cornelia Schiller, Marco Sifringer, Ivo Bendix, Christoph Bührer
Phenobarbital is the most commonly used drug for the treatment of neonatal seizures but may induce neurodegeneration in the developing brain. Methylxanthine caffeine is used for the treatment of apnea in newborn infants and appears to be neuroprotective, as shown by antiapoptotic and anti-inflammatory effects in oxidative stress models in newborn rodents and reduced rates of cerebral palsy in human infants treated with caffeine. We hypothesized that caffeine may counteract the proapoptotic effects of phenobarbital in newborn rats...
June 22, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28588361/caffeine-and-cannabis-effects-on-vital-neurotransmitters-and-enzymes-in-the-brain-tissue-of-juvenile-experimental-rats
#2
J O Owolabi, S Y Olatunji, A J Olanrewaju
BACKGROUND: Caffeine and cannabis are globally consumed and abused psychoactive substances. While caffeine is legally used in various forms, including in tea and coffee as beverages, it is also consumed in soda and energy drinks as additives. Cannabis, on the other hand, is considered illegal in most countries; albeit, it is being consumed globally particularly by adolescents. PURPOSE: The adolescent stage marks a critical stage of brain development and maturation...
May 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28582855/diabetes-and-alzheimer-s-disease-can-tea-phytochemicals-play-a-role-in-prevention
#3
Warnakulasuriya M A D B Fernando, Geeshani Somaratne, Kathryn G Goozee, Shehan Williams, Harjinder Singh, Ralph N Martins
Dementia and diabetes mellitus are prevalent disorders in the elderly population. While recognized as two distinct diseases, diabetes has more recently recognized as a significant contributor to risk for developing dementia, and some studies make reference to type 3 diabetes, a condition resulting from insulin resistance in the brain. Alzheimer's disease, the most common form of dementia, and diabetes, interestingly, share underlying pathological processes, commonality in risk factors, and, importantly, pathways for intervention...
May 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28576568/early-life-exposure-to-caffeine-affects-the-construction-and-activity-of-cortical-networks-in-mice
#4
Walid Fazeli, Stefania Zappettini, Stephan Lawrence Marguet, Jasper Grendel, Monique Esclapez, Christophe Bernard, Dirk Isbrandt
The consumption of psychoactive drugs during pregnancy can have deleterious effects on newborns. It remains unclear whether early-life exposure to caffeine, the most widely consumed psychoactive substance, alters brain development. We hypothesized that maternal caffeine ingestion during pregnancy and the early postnatal period in mice affects the construction and activity of cortical networks in offspring. To test this hypothesis, we focused on primary visual cortex (V1) as a model neocortical region. In a study design mimicking the daily consumption of approximately three cups of coffee during pregnancy in humans, caffeine was added to the drinking water of female mice and their offspring were compared to control offspring...
May 30, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28555252/the-perinatal-effects-of-maternal-caffeine-intake-on-fetal-and-neonatal-brain-levels-of-testosterone-estradiol-and-dihydrotestosterone-in-rats
#5
S Karaismailoglu, M Tuncer, S Bayrak, G Erdogan, E L Ergun, A Erdem
Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible for the organization and sexual differentiation of brain structures during early development. The hypothalamo-pituitary-adrenocortical axis, adrenal cells, and gonads play a key role in the production of sex steroids and express adenosine receptors. Caffeine is a non-selective adenosine antagonist; therefore, it can modulate metabolic pathways in these tissues. Besides, the proportion of pregnant women that consume caffeine is ∼60%...
August 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28480791/reversible-cerebral-vasoconstriction-syndrome-secondary-to-caffeine-withdrawal
#6
Dheeraj Kalladka, Aslam Siddiqui, Alok Tyagi, Edward Newman
We describe a 39-year-old man who developed thunderclap headaches during a hospital admission for accidental superficial burns. His magnetic resonance brain imaging was normal expect for diffuse segmental vasoconstriction. Prior to admission, he was consuming excessive amounts of caffeine which was restarted and slowly tapered and stopped over weeks. Repeat magnetic resonance angiogram showed resolution of segmental vasoconstriction. The implications of prescribed and non-prescribed drugs on cerebral vasculature have been discussed...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28420694/caffeine-preferentially-protects-against-oxygen-induced-retinopathy
#7
Shuya Zhang, Rong Zhou, Bo Li, Haiyan Li, Yanyan Wang, Xuejiao Gu, Lingyun Tang, Cun Wang, Dingjuan Zhong, Yuanyuan Ge, Yuqing Huo, Jing Lin, Xiao-Ling Liu, Jiang-Fan Chen
Retinopathy of prematurity (ROP) is the leading cause of childhood blindness, but current anti-VEGF therapy is concerned with delayed retinal vasculature, eye, and brain development of preterm infants. The clinical observation of reduced ROP severity in premature infants after caffeine treatment for apnea suggests that caffeine may protect against ROP. Here, we demonstrate that caffeine did not interfere with normal retinal vascularization development but selectively protected against oxygen-induced retinopathy (OIR) in mice...
April 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28345118/effect-of-paullinia-cupana-mart-commercial-extract-during-the-aging-of-middle-age-wistar-rats-differential-effects-on-the-hippocampus-and-striatum
#8
Moara Rodrigues Mingori, Luana Heimfarth, Charles Francisco Ferreira, Henrique Mautone Gomes, Karla Suzana Moresco, Jeferson Delgado, Sabrina Roncato, Fares Zeidán-Chuliá, Daniel Pens Gelain, José Cláudio Fonseca Moreira
During aging, there is a marked decline in the antioxidant capacity of brain tissue, leading to a gradual loss of the antioxidant/oxidant balance, which causes oxidative damage. The effects of Paullinia cupana Mart. extract, which is described as being rich in caffeine and many polyphenol compounds, on the central nervous system have not been extensively investigated. The aim of this study was to therefore investigate the effect of a commercial guarana extract (CGE) on cognitive function, oxidative stress, and brain homeostasis proteins related to cognitive injury and senescence in middle age, male Wistar rats...
August 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28106777/neuroprotection-by-caffeine-in-hyperoxia-induced-neonatal-brain-injury
#9
Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schlör, Marco Sifringer, Till Scheuer, Christoph Bührer, Thomas Schmitz
Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term "oxygen radical disease of prematurity". Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28062599/in-vivo-evaluation-of-11-c-preladenant-for-pet-imaging-of-adenosine-a2a-receptors-in-the-conscious-monkey
#10
Xiaoyun Zhou, Ronald Boellaard, Kiichi Ishiwata, Muneyuki Sakata, Rudi A J O Dierckx, Johan R de Jong, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Erik F J de Vries, Philip H Elsinga
(11)C-preladenant was developed as a novel PET ligand for the adenosine A2A receptors (A2ARs). The present study aimed to evaluate the suitability of (11)C-preladenant PET for the quantification of striatal A2ARs and the assessment of A2AR occupancy in the conscious monkey brain. Methods:(11)C-preladenant was intravenously injected into conscious monkeys (n = 4, 18 PET scans), and a 91-min dynamic scan was started. Arterial blood samples in combination with metabolite analysis were obtained during the scan to provide the input function for kinetic modeling...
May 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27924651/caffeine-combined-with-sedative-anesthetic-drugs-triggers-widespread-neuroapoptosis-in-a-mouse-model-of-prematurity
#11
Omar Hoseá Cabrera, Shawn David O'Connor, Brant Stephen Swiney, Patricia Salinas-Contreras, Francesca Maria Manzella, George Townsend Taylor, Kevin Kiyoshi Noguchi
OBJECTIVES: Caffeine (CAF) and sedative/anesthetic drugs (SADs) are often coadministered to premature infants in the neonatal intensive care unit (NICU). While SAD neurotoxicity in the developing brain is well established, it is not fully clear whether CAF interacts with SADs and whether this interaction is detrimental. Using a mouse model of prematurity, we hypothesized that CAF would increase apoptotic neurotoxicity when coadministered with SADs. METHODS: Postnatal day 3 mice were treated with vehicle or 80 mg/kg CAF prior to challenge with 6 mg/kg midazolam, 40 mg/kg ketamine, or 40 μg/kg fentanyl...
December 7, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27899304/caffeine-for-apnea-of-prematurity-effects-on-the-developing-brain
#12
REVIEW
Anzari Atik, Richard Harding, Robert De Matteo, Delphi Kondos-Devcic, Jeanie Cheong, Lex W Doyle, Mary Tolcos
Caffeine is a methylxanthine that is widely used to treat apnea of prematurity (AOP). In preterm infants, caffeine reduces the duration of respiratory support, improves survival rates and lowers the incidence of cerebral palsy and cognitive delay. There is, however, little evidence relating to the immediate and long-term effects of caffeine on brain development, especially at the cellular and molecular levels. Experimental data are conflicting, with studies showing that caffeine can have either adverse or benefical effects in the developing brain...
January 2017: Neurotoxicology
https://www.readbyqxmd.com/read/27751556/the-epidemiology-of-parkinson-s-disease-risk-factors-and-prevention
#13
REVIEW
Alberto Ascherio, Michael A Schwarzschild
Since 2006, several longitudinal studies have assessed environmental or behavioural factors that seem to modify the risk of developing Parkinson's disease. Increased risk of Parkinson's disease has been associated with exposure to pesticides, consumption of dairy products, history of melanoma, and traumatic brain injury, whereas a reduced risk has been reported in association with smoking, caffeine consumption, higher serum urate concentrations, physical activity, and use of ibuprofen and other common medications...
November 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27720901/guarana-paullinia-cupana-ameliorates-memory-impairment-and-modulates-acetylcholinesterase-activity-in-poloxamer-407-induced-hyperlipidemia-in-rat-brain
#14
Jader B Ruchel, Josiane B S Braun, Stephen A Adefegha, Alessandra Guedes Manzoni, Fátima H Abdalla, Juliana S de Oliveira, Kelly Trelles, Cristiane Signor, Sônia T A Lopes, Cássia B da Silva, Lívia G Castilhos, Maribel A Rubin, Daniela B R Leal
Hyperlipidemia is a risk factor for the development of cognitive dysfunction and atherosclerosis. Natural compounds have recently received special attention in relation to the treatment of disease due to their low cost and wide margin of safety. Thus, the aim of this study was to determine the possible preventive effect of guarana powder (Paullinia cupana) on memory impairment and acetylcholinesterase (AChE) activity in the brain structures of rats with Poloxamer-407-induced hyperlipidemia. Adult male Wistar rats were pretreated with guarana (12...
January 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27565749/adolescent-intake-of-caffeinated-energy-drinks-does-not-affect-adult-alcohol-consumption-in-c57bl-6-and-balb-c-mice
#15
Meridith T Robins, Julia N DeFriel, Richard M van Rijn
The rise in marketing and mass consumption of energy drink products by adolescents poses a largely unknown risk on adolescent development and drug reward. Yet, with increasing reports of acute health issues present in young adults who ingest large quantities of energy drinks alone or in combination with alcohol, the need to elucidate these potential risks is pressing. Energy drinks contain high levels of caffeine and sucrose; therefore, exposure to energy drinks may lead to changes in drug-related behaviors since caffeine and sucrose consumption activates similar brain pathways engaged by substances of abuse...
August 2016: Alcohol
https://www.readbyqxmd.com/read/27399645/microfluidic-blood-brain-barrier-model-provides-in-vivo-like-barrier-properties-for-drug-permeability-screening
#16
Ying I Wang, Hasan Erbil Abaci, Michael L Shuler
Efficient delivery of therapeutics across the neuroprotective blood-brain barrier (BBB) remains a formidable challenge for central nervous system drug development. High-fidelity in vitro models of the BBB could facilitate effective early screening of drug candidates targeting the brain. In this study, we developed a microfluidic BBB model that is capable of mimicking in vivo BBB characteristics for a prolonged period and allows for reliable in vitro drug permeability studies under recirculating perfusion. We derived brain microvascular endothelial cells (BMECs) from human induced pluripotent stem cells (hiPSCs) and cocultured them with rat primary astrocytes on the two sides of a porous membrane on a pumpless microfluidic platform for up to 10 days...
January 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27053210/individual-differences-in-cognitive-control-circuit-anatomy-link-sensation-seeking-impulsivity-and-substance-use
#17
Avram J Holmes, Marisa O Hollinshead, Joshua L Roffman, Jordan W Smoller, Randy L Buckner
UNLABELLED: Individuals vary widely in their tendency to seek stimulation and act impulsively, early developing traits with genetic origins. Failures to regulate these behaviors increase risk for maladaptive outcomes including substance abuse. Here, we explored the neuroanatomical correlates of sensation seeking and impulsivity in healthy young adults. Our analyses revealed links between sensation seeking and reduced cortical thickness that were preferentially localized to regions implicated in cognitive control, including anterior cingulate and middle frontal gyrus (n = 1015)...
April 6, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27007534/the-effects-of-caffeine-administered-at-different-temperatures-on-foetal-development
#18
Marek Tomaszewski, Franciszek Burdan, Grażyna Olchowik, Monika Tomaszewska
An easy access to products containing caffeine makes it widely consumed to excess by the general population, including pregnant women. Beverages containing caffeine are consumed at different temperatures (iced, hot, room temperature). Caffeine easily passes through biological membranes, including the blood-brain barrier, the placental barrier, and can also enter the amniotic fluid, breast milk and semen. The aim of this study was to evaluate the relationship between caffeine's developmental toxicity, and the solution's temperature (both low and high) administered to pregnant female rats...
2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/26976495/caffeine-administration-to-prevent-apnea-in-very-premature-infants
#19
Amir-Mohammad Armanian, Ramin Iranpour, Eiman Faghihian, Nima Salehimehr
BACKGROUND: Apnea intervals frequently occur in premature infants. Periods of apnea occur more often with decreases in gestational age. Periods of apnea can cause damage to the infant's developing brain and other organs. This study was designed to investigate the preventive effects of caffeine on apnea incidence in higher-risk neonates. METHODS: In this single-center randomized control trial study, premature infants with a birth weight of ≤1200 g were eligible for enrollment...
October 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/26790872/validation-of-an-immortalized-human-hbmec-in-vitro-blood-brain-barrier-model
#20
Daniela Elisabeth Eigenmann, Evelyn Andrea Jähne, Martin Smieško, Matthias Hamburger, Mouhssin Oufir
We recently established and optimized an immortalized human in vitro blood-brain barrier (BBB) model based on the hBMEC cell line. In the present work, we validated this mono-culture 24-well model with a representative series of drug substances which are known to cross or not to cross the BBB. For each individual compound, a quantitative UHPLC-MS/MS method in Ringer HEPES buffer was developed and validated according to current regulatory guidelines, with respect to selectivity, precision, and reliability. Various biological and analytical challenges were met during method validation, highlighting the importance of careful method development...
March 2016: Analytical and Bioanalytical Chemistry
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