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caffeine, brain development

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https://www.readbyqxmd.com/read/29605768/perinatal-exposure-to-energy-drink-induces-oxidative-damage-in-the-liver-kidney-and-brain-and-behavioral-alterations-in-mice-offspring
#1
Gadh I Al-Basher, Hanan Aljabal, Rafa S Almeer, Ahmed A Allam, Ayman M Mahmoud
The worldwide consumption of energy drinks (EDs) has increased in recent years. EDs have several side effects and can be linked to liver injury, kidney damage and risk-seeking behavior. The impact of perinatal consumption of EDs on the newborns has not been previously investigated. In this study, we evaluated the effects of perinatal exposure to a caffeinated ED on the liver, kidney, brain, locomotor activity and anxiety in mice newborns. Pregnant mice received 2.5 or 5 ml ED by oral gavage from the first day of pregnancy until day 15 after birth...
March 29, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29593226/caffeine-augments-anesthesia-neurotoxicity-in-the-fetal-macaque-brain
#2
Kevin K Noguchi, Stephen A Johnson, Francesca M Manzella, Kobe L Masuoka, Sasha L Williams, Lauren D Martin, Gregory A Dissen, Chrysanthy Ikonomidou, Katie J Schenning, John W Olney, Ansgar M Brambrink
Caffeine is the most frequently used medication in premature infants. It is the respiratory stimulant of choice for apnea associated with prematurity and has been called the silver bullet in neonatology because of many proven benefits and few known risks. Research has revealed that sedative/anesthetic drugs trigger apoptotic death of neurons and oligodendrocytes in developing mammalian brains. Here we evaluated the influence of caffeine on the neurotoxicity of anesthesia in developing nonhuman primate brains...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29512445/an-insight-on-the-therapeutic-potential-of-major-coffee-components
#3
Muhammad Torequl Islam, Shams Tabrez, Nasimudeen R Jabir, Murtaza Ali, Mohammad A Kamal, Lidiane da Silva Araujo, Jose Victor De Oliveira Santos, Ana Maria Oliveira Ferreira Da Mata, Rai Pablo Sousa De Aguiar, Ana Amelia de Carvalho Melo Cavalcante
The popular drink, coffee (Coffea arabica) is under the great attention of late because of its promising pharmacological potential. Caffeine (the major constituent of coffee) is known for its prominent psychoactive impact. This review aims at highlighting the therapeutic potentials of caffeine and other five coffee components viz. caffeic acid, chlorogenic acids, cafestol, ferulic acid and kahweol and their suggested mechanisms of action. A number of pharmacological activities are attributed to these components that include anti-oxidant, anti-inflammatory, immunomodulatory, anti-microbial, anti-cancer, cardioprotective and neuroprotective effects...
March 2, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29498762/the-effects-of-capillary-transit-time-heterogeneity-on-the-bold-signal
#4
Hugo Angleys, Sune N Jespersen, Leif Østergaard
Neurovascular coupling mechanisms give rise to vasodilation and functional hyperemia upon neural activation, thereby altering blood oxygenation. This blood oxygenation level dependent (BOLD) contrast allows studies of activation patterns in the working human brain by functional MRI (fMRI). The BOLD-weighted fMRI signal shows characteristic transients in relation to functional activation, such as the so-called initial dip, overshoot, and post-stimulus undershoot. These transients are modulated by other physiological stimuli and in disease, but the underlying physiological mechanisms remain incompletely understood...
June 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29417440/caffeine-protects-against-anticonvulsant-induced-impaired-neurogenesis-in-the-developing-rat-brain
#5
Stefanie Endesfelder, Ulrike Weichelt, Cornelia Schiller, Katja Winter, Clarissa von Haefen, Christoph Bührer
In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for caffeine both in newborn rodents and preterm human infants. To characterize the interaction of phenobarbital and caffeine in the hippocampus of the developing rodent brain, we examined the effects of both drugs given separately or together on postnatal neurogenesis after administration to neonatal rats throughout postnatal day (P) 4 to P6...
February 7, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29360435/cerebellar-oxidative-stress-and-fine-motor-impairment-in-adolescent-rats-exposed-to-hyperthermia-induced-seizures-is-prevented-by-maternal-caffeine-intake-during-gestation-and-lactation
#6
María Crespo, David Agustín León-Navarro, Mairena Martín
Febrile seizures (FS) is one of the most common convulsive disorders in infants and young children that only occurs during the first years of life in humans, when the cerebellum is still developing. Several works have shown that maternal caffeine consumption during gestation and lactation can exert protective effects on developing brain under pathological conditions. Here, we have used an animal model of FS to know whether maternal caffeine consumption during gestation and lactation exhibited protective effects on rat cerebellum...
March 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29327202/transient-disruption-of-adenosine-signaling-during-embryogenesis-triggers-a-pro-epileptic-phenotype-in-adult-zebrafish
#7
Fabiano Peres Menezes, Felipe Machado Torresini, Laura Roesler Nery, Rosane Souza da Silva
Adenosinergic signaling has important effects on brain function, anatomy, and physiology in both late and early stages of development. Exposure to caffeine, a non-specific blocker of adenosine receptor, has been indicated as a developmental risk factor. Disruption of adenosinergic signaling during early stages of development can change the normal neural network formation and possibly lead to an increase in susceptibility to seizures. In this work, morpholinos (MO) temporarily blocked the translation of adenosine receptor transcripts, adora1, adora2aa, and adora2ab, during the embryonic phase of zebrafish...
January 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29251842/taurine-caffeine-and-energy-drinks-reviewing-the-risks-to-the-adolescent-brain
#8
REVIEW
Christine Perdan Curran, Cecile A Marczinski
Energy drinks are emerging as a major component of the beverage market with sales projected to top $60 billion globally in the next five years. Energy drinks contain a variety of ingredients, but many of the top-selling brands include high doses of caffeine and the amino acid taurine. Energy drink consumption by children has raised concerns, due to potential caffeine toxicity. An additional risk has been noted among college-aged consumers of energy drinks who appear at higher risk of over-consumption of alcohol when the two drinks are consumed together...
December 1, 2017: Birth defects research
https://www.readbyqxmd.com/read/29024709/caffeine-administration-alters-the-behaviour-and-development-of-galleria-mellonella-larvae
#9
Ronan Maguire, Martin Kunc, Pavel Hyrsl, Kevin Kavanagh
The effect of feeding caffeine on the behaviour and neural proteome of Galleria mellonella larvae was assessed. Caffeine was administered to larvae by force feeding and the metabolites theobromine and theophylline were subsequently detected by RP-HPLC analysis. Administration of caffeine to larvae resulted in reduced movement and a reduction in the formation of pupae. The production of the muscle relaxant theophylline may contribute to the reduction in larval movement. Analysis of the changes in proteome of the brain and surrounding tissues of caffeine fed larvae revealed an increase in the abundance of immune related proteins such as immune-related Hdd1 (6...
October 9, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28826637/sex-differences-in-the-effects-of-pre-and-postnatal-caffeine-exposure-on-behavior-and-synaptic-proteins-in-pubescent-rats
#10
Cássia Sallaberry, Ana Paula Ardais, Andréia Rocha, Maurício Felisberto Borges, Gabriela T Fioreze, Sabrina Mioranzza, Fernanda Nunes, Natália Pagnussat, Paulo Henrique S Botton, Lisiane O Porciúncula
Few studies have addressed the effects of caffeine in the puberty and/or adolescence in a sex dependent manner. Considering that caffeine intake has increased in this population, we investigated the behavioral and synaptic proteins changes in pubescent male and female rats after maternal consumption of caffeine. Adult female Wistar rats started to receive water or caffeine (0.1 and 0.3g/L in drinking water; low and moderate dose, respectively) during the active cycle at weekdays, two weeks before mating. The treatment lasted up to weaning and the offspring received caffeine until the onset of puberty (30-34days old)...
August 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28810965/the-benefits-and-risks-of-energy-drinks-in-young-adults-and-military-service-members
#11
Julianne Manchester, Inbal Eshel, Donald W Marion
INTRODUCTION: Energy drinks (EDs) have become an integral part of the young adult, athletic, and military culture. Many athletes are convinced that EDs enhance performance, and service members as well as college students frequently use EDs as stimulants to counter sleep deprivation, or to improve academic performance. However, concerns have been raised by some military leaders about potential adverse effects of EDs. MATERIALS AND METHODS: A needs assessment survey of a convenience sample of military health care providers was conducted and identified EDs as a top knowledge need for those providers working in the area of traumatic brain injury (TBI)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28643232/caffeine-protects-against-anticonvulsant-induced-neurotoxicity-in-the-developing-rat-brain
#12
Stefanie Endesfelder, Ulrike Weichelt, Cornelia Schiller, Marco Sifringer, Ivo Bendix, Christoph Bührer
Phenobarbital is the most commonly used drug for the treatment of neonatal seizures but may induce neurodegeneration in the developing brain. Methylxanthine caffeine is used for the treatment of apnea in newborn infants and appears to be neuroprotective, as shown by antiapoptotic and anti-inflammatory effects in oxidative stress models in newborn rodents and reduced rates of cerebral palsy in human infants treated with caffeine. We hypothesized that caffeine may counteract the proapoptotic effects of phenobarbital in newborn rats...
October 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28588361/caffeine-and-cannabis-effects-on-vital-neurotransmitters-and-enzymes-in-the-brain-tissue-of-juvenile-experimental-rats
#13
J O Owolabi, S Y Olatunji, A J Olanrewaju
BACKGROUND: Caffeine and cannabis are globally consumed and abused psychoactive substances. While caffeine is legally used in various forms, including in tea and coffee as beverages, it is also consumed in soda and energy drinks as additives. Cannabis, on the other hand, is considered illegal in most countries; albeit, it is being consumed globally particularly by adolescents. PURPOSE: The adolescent stage marks a critical stage of brain development and maturation...
May 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28582855/diabetes-and-alzheimer-s-disease-can-tea-phytochemicals-play-a-role-in-prevention
#14
Warnakulasuriya M A D B Fernando, Geeshani Somaratne, Kathryn G Goozee, Shehan Williams, Harjinder Singh, Ralph N Martins
Dementia and diabetes mellitus are prevalent disorders in the elderly population. While recognized as two distinct diseases, diabetes has more recently recognized as a significant contributor to risk for developing dementia, and some studies make reference to type 3 diabetes, a condition resulting from insulin resistance in the brain. Alzheimer's disease, the most common form of dementia, and diabetes, interestingly, share underlying pathological processes, commonality in risk factors, and, importantly, pathways for intervention...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28576568/early-life-exposure-to-caffeine-affects-the-construction-and-activity-of-cortical-networks-in-mice
#15
Walid Fazeli, Stefania Zappettini, Stephan Lawrence Marguet, Jasper Grendel, Monique Esclapez, Christophe Bernard, Dirk Isbrandt
The consumption of psychoactive drugs during pregnancy can have deleterious effects on newborns. It remains unclear whether early-life exposure to caffeine, the most widely consumed psychoactive substance, alters brain development. We hypothesized that maternal caffeine ingestion during pregnancy and the early postnatal period in mice affects the construction and activity of cortical networks in offspring. To test this hypothesis, we focused on primary visual cortex (V1) as a model neocortical region. In a study design mimicking the daily consumption of approximately three cups of coffee during pregnancy in humans, caffeine was added to the drinking water of female mice and their offspring were compared to control offspring...
September 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28555252/the-perinatal-effects-of-maternal-caffeine-intake-on-fetal-and-neonatal-brain-levels-of-testosterone-estradiol-and-dihydrotestosterone-in-rats
#16
S Karaismailoglu, M Tuncer, S Bayrak, G Erdogan, E L Ergun, A Erdem
Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible for the organization and sexual differentiation of brain structures during early development. The hypothalamo-pituitary-adrenocortical axis, adrenal cells, and gonads play a key role in the production of sex steroids and express adenosine receptors. Caffeine is a non-selective adenosine antagonist; therefore, it can modulate metabolic pathways in these tissues. Besides, the proportion of pregnant women that consume caffeine is ∼60%...
August 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28480791/reversible-cerebral-vasoconstriction-syndrome-secondary-to-caffeine-withdrawal
#17
Dheeraj Kalladka, Aslam Siddiqui, Alok Tyagi, Edward Newman
We describe a 39-year-old man who developed thunderclap headaches during a hospital admission for accidental superficial burns. His magnetic resonance brain imaging was normal expect for diffuse segmental vasoconstriction. Prior to admission, he was consuming excessive amounts of caffeine which was restarted and slowly tapered and stopped over weeks. Repeat magnetic resonance angiogram showed resolution of segmental vasoconstriction. The implications of prescribed and non-prescribed drugs on cerebral vasculature have been discussed...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28420694/caffeine-preferentially-protects-against-oxygen-induced-retinopathy
#18
Shuya Zhang, Rong Zhou, Bo Li, Haiyan Li, Yanyan Wang, Xuejiao Gu, Lingyun Tang, Cun Wang, Dingjuan Zhong, Yuanyuan Ge, Yuqing Huo, Jing Lin, Xiao-Ling Liu, Jiang-Fan Chen
Retinopathy of prematurity (ROP) is the leading cause of childhood blindness, but current anti-VEGF therapy is concerned with delayed retinal vasculature, eye, and brain development of preterm infants. The clinical observation of reduced ROP severity in premature infants after caffeine treatment for apnea suggests that caffeine may protect against ROP. Here, we demonstrate that caffeine did not interfere with normal retinal vascularization development but selectively protected against oxygen-induced retinopathy (OIR) in mice...
August 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28345118/effect-of-paullinia-cupana-mart-commercial-extract-during-the-aging-of-middle-age-wistar-rats-differential-effects-on-the-hippocampus-and-striatum
#19
Moara Rodrigues Mingori, Luana Heimfarth, Charles Francisco Ferreira, Henrique Mautone Gomes, Karla Suzana Moresco, Jeferson Delgado, Sabrina Roncato, Fares Zeidán-Chuliá, Daniel Pens Gelain, José Cláudio Fonseca Moreira
During aging, there is a marked decline in the antioxidant capacity of brain tissue, leading to a gradual loss of the antioxidant/oxidant balance, which causes oxidative damage. The effects of Paullinia cupana Mart. extract, which is described as being rich in caffeine and many polyphenol compounds, on the central nervous system have not been extensively investigated. The aim of this study was to therefore investigate the effect of a commercial guarana extract (CGE) on cognitive function, oxidative stress, and brain homeostasis proteins related to cognitive injury and senescence in middle age, male Wistar rats...
August 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28106777/neuroprotection-by-caffeine-in-hyperoxia-induced-neonatal-brain-injury
#20
Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schlör, Marco Sifringer, Till Scheuer, Christoph Bührer, Thomas Schmitz
Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term "oxygen radical disease of prematurity". Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats...
January 18, 2017: International Journal of Molecular Sciences
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