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caffeine, brain development

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https://www.readbyqxmd.com/read/27899304/caffeine-for-apnea-of-prematurity-effects-on-the-developing-brain
#1
REVIEW
Anzari Atik, Richard Harding, Robert De Matteo, Delphi Kondos-Devcic, Jeanie Cheong, Lex W Doyle, Mary Tolcos
Caffeine is a methylxanthine that is widely used to treat apnea of prematurity (AOP). In preterm infants, caffeine reduces the duration of respiratory support, improves survival rates and lowers the incidence of cerebral palsy and cognitive delay. There is, however, little evidence relating to the immediate and long-term effects of caffeine on brain development, especially at the cellular and molecular levels. Experimental data are conflicting, with studies showing that caffeine can have either adverse or benefical effects in the developing brain...
November 26, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27751556/the-epidemiology-of-parkinson-s-disease-risk-factors-and-prevention
#2
Alberto Ascherio, Michael A Schwarzschild
Since 2006, several longitudinal studies have assessed environmental or behavioural factors that seem to modify the risk of developing Parkinson's disease. Increased risk of Parkinson's disease has been associated with exposure to pesticides, consumption of dairy products, history of melanoma, and traumatic brain injury, whereas a reduced risk has been reported in association with smoking, caffeine consumption, higher serum urate concentrations, physical activity, and use of ibuprofen and other common medications...
November 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27720901/guarana-paullinia-cupana-ameliorates-memory-impairment-and-modulates-acetylcholinesterase-activity-in-poloxamer-407-induced-hyperlipidemia-in-rat-brain
#3
Jader B Ruchel, Josiane B S Braun, Stephen A Adefegha, Alessandra Guedes Manzoni, Fátima H Abdalla, Juliana S de Oliveira, Kelly Trelles, Cristiane Signor, Sônia T A Lopes, Cássia B da Silva, Lívia G Castilhos, Maribel A Rubin, Daniela B R Leal
Hyperlipidemia is a risk factor for the development of cognitive dysfunction and atherosclerosis. Natural compounds have recently received special attention in relation to the treatment of disease due to their low cost and wide margin of safety. Thus, the aim of this study was to determine the possible preventive effect of guarana powder (Paullinia cupana) on memory impairment and acetylcholinesterase (AChE) activity in the brain structures of rats with Poloxamer-407-induced hyperlipidemia. Adult male Wistar rats were pretreated with guarana (12...
January 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27565749/adolescent-intake-of-caffeinated-energy-drinks-does-not-affect-adult-alcohol-consumption-in-c57bl-6-and-balb-c-mice
#4
Meridith T Robins, Julia N DeFriel, Richard M van Rijn
The rise in marketing and mass consumption of energy drink products by adolescents poses a largely unknown risk on adolescent development and drug reward. Yet, with increasing reports of acute health issues present in young adults who ingest large quantities of energy drinks alone or in combination with alcohol, the need to elucidate these potential risks is pressing. Energy drinks contain high levels of caffeine and sucrose; therefore, exposure to energy drinks may lead to changes in drug-related behaviors since caffeine and sucrose consumption activates similar brain pathways engaged by substances of abuse...
August 2016: Alcohol
https://www.readbyqxmd.com/read/27399645/microfluidic-blood-brain-barrier-model-provides-in-vivo-like-barrier-properties-for-drug-permeability-screening
#5
Ying I Wang, Hasan Erbil Abaci, Michael L Shuler
Efficient delivery of therapeutics across the neuroprotective blood-brain barrier (BBB) remains a formidable challenge for central nervous system drug development. High-fidelity in vitro models of the BBB could facilitate effective early screening of drug candidates targeting the brain. In this study, we developed a microfluidic BBB model that is capable of mimicking in vivo BBB characteristics for a prolonged period and allows for reliable in vitro drug permeability studies under recirculating perfusion. We derived brain microvascular endothelial cells (BMECs) from human induced pluripotent stem cells (hiPSCs) and cocultured them with rat primary astrocytes on the two sides of a porous membrane on a pumpless microfluidic platform for up to 10 days...
January 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27053210/individual-differences-in-cognitive-control-circuit-anatomy-link-sensation-seeking-impulsivity-and-substance-use
#6
Avram J Holmes, Marisa O Hollinshead, Joshua L Roffman, Jordan W Smoller, Randy L Buckner
UNLABELLED: Individuals vary widely in their tendency to seek stimulation and act impulsively, early developing traits with genetic origins. Failures to regulate these behaviors increase risk for maladaptive outcomes including substance abuse. Here, we explored the neuroanatomical correlates of sensation seeking and impulsivity in healthy young adults. Our analyses revealed links between sensation seeking and reduced cortical thickness that were preferentially localized to regions implicated in cognitive control, including anterior cingulate and middle frontal gyrus (n = 1015)...
April 6, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27007534/the-effects-of-caffeine-administered-at-different-temperatures-on-foetal-development
#7
Marek Tomaszewski, Franciszek Burdan, Grażyna Olchowik, Monika Tomaszewska
An easy access to products containing caffeine makes it widely consumed to excess by the general population, including pregnant women. Beverages containing caffeine are consumed at different temperatures (iced, hot, room temperature). Caffeine easily passes through biological membranes, including the blood-brain barrier, the placental barrier, and can also enter the amniotic fluid, breast milk and semen. The aim of this study was to evaluate the relationship between caffeine's developmental toxicity, and the solution's temperature (both low and high) administered to pregnant female rats...
2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/26976495/caffeine-administration-to-prevent-apnea-in-very-premature-infants
#8
Amir-Mohammad Armanian, Ramin Iranpour, Eiman Faghihian, Nima Salehimehr
BACKGROUND: Apnea intervals frequently occur in premature infants. Periods of apnea occur more often with decreases in gestational age. Periods of apnea can cause damage to the infant's developing brain and other organs. This study was designed to investigate the preventive effects of caffeine on apnea incidence in higher-risk neonates. METHODS: In this single-center randomized control trial study, premature infants with a birth weight of ≤1200 g were eligible for enrollment...
January 28, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/26790872/validation-of-an-immortalized-human-hbmec-in-vitro-blood-brain-barrier-model
#9
Daniela Elisabeth Eigenmann, Evelyn Andrea Jähne, Martin Smieško, Matthias Hamburger, Mouhssin Oufir
We recently established and optimized an immortalized human in vitro blood-brain barrier (BBB) model based on the hBMEC cell line. In the present work, we validated this mono-culture 24-well model with a representative series of drug substances which are known to cross or not to cross the BBB. For each individual compound, a quantitative UHPLC-MS/MS method in Ringer HEPES buffer was developed and validated according to current regulatory guidelines, with respect to selectivity, precision, and reliability. Various biological and analytical challenges were met during method validation, highlighting the importance of careful method development...
March 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/26775960/metal-chelation-radical-scavenging-and-inhibition-of-a%C3%AE-%C3%A2-%C3%A2-fibrillation-by-food-constituents-in-relation-to-alzheimer-s-disease
#10
Stephen Chan, Srinivas Kantham, Venkatesan M Rao, Manoj Kumar Palanivelu, Hoang L Pham, P Nicholas Shaw, Ross P McGeary, Benjamin P Ross
Various food constituents have been proposed as disease-modifying agents for Alzheimer's disease (AD), due to epidemiological evidence of their beneficial effects, and for their ability to ameliorate factors linked to AD pathogenesis, namely by: chelating iron, copper and zinc; scavenging reactive oxygen species; and suppressing the fibrillation of amyloid-beta peptide (Aβ). In this study, nine different food constituents (l-ascorbic acid, caffeic acid, caffeine, curcumin, (-)-epigallocatechin gallate (EGCG), gallic acid, propyl gallate, resveratrol, and α-tocopherol) were investigated for their effects on the above factors, using metal chelation assays, antioxidant assays, and assays of Aβ42 fibrillation...
May 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26774980/caffeine-exposure-during-rat-brain-development-causes-memory-impairment-in-a-sex-selective-manner-that-is-offset-by-caffeine-consumption-throughout-life
#11
Ana Paula Ardais, Andréia S Rocha, Maurício Felisberto Borges, Gabriela T Fioreze, Cássia Sallaberry, Sabrina Mioranzza, Fernanda Nunes, Natália Pagnussat, Paulo Henrique S Botton, Rodrigo A Cunha, Lisiane de Oliveira Porciúncula
Caffeine is the psychostimulant most consumed worldwide. In moderate doses, it affords a beneficial effect in adults and upon aging, but has a deleterious effect during brain development. We now tested if caffeine consumption by rats (0.1, 0.3, 1.0 g/L in the drinking water, only during active cycle and weekdays) during adulthood could revert the potentially negative effects of caffeine during early life. Thus, we compared caffeine intake starting 15 days before mating and lasting either up to weaning (development) or up to adulthood, on behavior and synaptic proteins in male and female rats...
April 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26677204/effects-of-coffee-caffeine-on-brain-health-and-disease-what-should-i-tell-my-patients
#12
REVIEW
Astrid Nehlig
Over the last decade, Food Regulation Authorities have concluded that coffee/caffeine consumption is not harmful if consumed at levels of 200 mg in one sitting (around 2½ cups of coffee) or 400 mg daily (around 5 cups of coffee). In addition, caffeine has many positive actions on the brain. It can increase alertness and well-being, help concentration, improve mood and limit depression. Caffeine may disturb sleep, but only in sensitive individuals. It may raise anxiety in a small subset of particularly sensitive people...
April 2016: Practical Neurology
https://www.readbyqxmd.com/read/26626862/antidepressive-like-effects-and-antioxidant-activity-of-green-tea-and-gaba-green-tea-in-a-mouse-model-of-post-stroke-depression
#13
Arianna Di Lorenzo, Seyed Fazel Nabavi, Antoni Sureda, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani, Patrizia Arcidiaco, Seyed Mohammad Nabavi, Maria Daglia
SCOPE: Growing evidence suggests that oxidative stress plays a role in the development of chronic diseases such as cardiovascular disease and some psychiatric disorders. Tea consumption exerts beneficial effects against damage induced by cerebral ischemia-reperfusion in ischemic stroke and depressive symptoms in depression. The aim of this study was to evaluate, in vivo, the protective activity of green tea (GT) and GABA green tea (GGT) against post-stroke depression (PSD), a common consequence of stroke...
March 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26444074/prenatal-caffeine-exposure-and-child-iq-at-age-5-5-years-the-eden-mother-child-cohort
#14
Cédric Galéra, Jonathan Y Bernard, Judith van der Waerden, Manuel-Pierre Bouvard, Sandrine Lioret, Anne Forhan, Maria De Agostini, Maria Melchior, Barbara Heude
BACKGROUND: Evidence from animal studies suggests maternal caffeine intake during pregnancy has detrimental effects on subsequent brain development in offspring. However, human data in this area are limited. The aim of this study was to assess whether caffeine intake by women during pregnancy is associated with impaired cognitive development in offspring at age 5.5 years. METHODS: Multivariate modeling was conducted using data of 1083 mother-child pairs from a population-based birth cohort in France followed from pregnancy to age 5...
November 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/26220901/plant-alkaloids-as-drug-leads-for-alzheimer-s-disease
#15
REVIEW
Yu Pong Ng, Terry Cho Tsun Or, Nancy Y Ip
Alzheimer's disease (AD) is a neurodegenerative illness associated with dementia and is most prevalent among the elderly population. Current medications can only treat symptoms. Alkaloids are structurally diverse and have been an important source of therapeutics for various brain disorders. Two US Food and Drug Administration (FDA)-approved acetylcholinesterase inhibitors for AD, galantamine and rivastigmine, are in fact alkaloids. In addition, clinical trials of four other extensively studied alkaloids-huperzine A, caffeine, nicotine, and indomethacin-have been conducted but do not convincingly demonstrate their clinical efficacy for AD...
October 2015: Neurochemistry International
https://www.readbyqxmd.com/read/26047722/methylxanthine-evoked-perturbation-of-spontaneous-and-evoked-activities-in-isolated-newborn-rat-hippocampal-networks
#16
A Ruangkittisakul, S Sharopov, C Kantor, J Kuribayashi, E Mildenberger, H J Luhmann, W Kilb, K Ballanyi
Treatment of apnea of prematurity with methylxanthines like caffeine, aminophylline or theophylline can evoke hippocampal seizures. However, it is unknown at which interstitial brain concentrations methylxanthines promote such neonatal seizures or interfere with physiological 'early network oscillations' (ENOs) that are considered as pivotal for maturation of hippocampal neural networks. We studied theophylline and caffeine effects on ENOs in CA3 neurons (CA3-ENOs) and CA3 electrical stimulation-evoked monosynaptic CA1 field potentials (CA1-FPs) in sliced and intact hippocampi, respectively, from 8 to 10-days-old rats...
August 20, 2015: Neuroscience
https://www.readbyqxmd.com/read/25977676/can-tea-consumption-be-a-safe-and-effective-therapy-against-diabetes-mellitus-induced-neurodegeneration
#17
Ana R Nunes, Marco G Alves, Paula I Moreira, Pedro F Oliveira, Branca M Silva
Diabetes mellitus (DM) is a metabolic disease that is rapidly increasing and has become a major public health problem. Type 2 DM (T2DM) is the most common type, accounting for up to 90-95% of the new diagnosed DM cases. The brain is very susceptible to glucose fluctuations and hyperglycemia-induced oxidative stress (OS). It is well known that DM and the risk of developing neurodegenerative diseases are associated. Tea, Camellia sinensis L., is one of the most consumed beverages. It contains several phytochemicals, such as polyphenols, methylxanthines (mainly caffeine) and L-theanine that are often reported to be responsible for tea's health benefits, including in brain...
December 2014: Current Neuropharmacology
https://www.readbyqxmd.com/read/25842372/neural-correlates-of-taste-and-pleasantness-evaluation-in-the-metabolic-syndrome
#18
Erin Green, Aaron Jacobson, Lori Haase, Claire Murphy
Metabolic syndrome (MetS) is a constellation of cardiometabolic abnormalities that commonly occur together and increase risk for cardiovascular disease and type II diabetes. Having MetS, especially during middle-age, increases the risk for dementia in later life. Abdominal obesity is a central feature of MetS; therefore, increased efforts to prevent obesity and identify predictors of weight gain are of extreme importance. Altered processing of food reward in the brain of obese individuals has been suggested to be a possible mechanism related to overeating...
September 16, 2015: Brain Research
https://www.readbyqxmd.com/read/25827925/concentration-and-age-dependent-effects-of-chronic-caffeine-on-contextual-fear-conditioning-in-c57bl-6j-mice
#19
Rachel L Poole, David Braak, Thomas J Gould
Chronic caffeine exerts negligible effects on learning and memory in normal adults, but it is unknown whether this is also true for children and adolescents. The hippocampus, a brain region important for learning and memory, undergoes extensive structural and functional modifications during pre-adolescence and adolescence. As a result, chronic caffeine may have differential effects on hippocampus-dependent learning in pre-adolescents and adolescents compared with adults. Here, we characterized the effects of chronic caffeine and withdrawal from chronic caffeine on hippocampus-dependent (contextual) and hippocampus-independent (cued) fear conditioning in pre-adolescent, adolescent, and adult mice...
February 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/25732217/coffee-tea-and-caffeine-consumption-and-prevention-of-late-life-cognitive-decline-and-dementia-a-systematic-review
#20
REVIEW
F Panza, V Solfrizzi, M R Barulli, C Bonfiglio, V Guerra, A Osella, D Seripa, C Sabbà, A Pilotto, G Logroscino
A prolonged preclinical phase of more than two decades before the onset of dementia suggested that initial brain changes of Alzheimer's disease (AD) and the symptoms of advanced AD may represent a unique continuum. Given the very limited therapeutic value of drugs currently used in the treatment of AD and dementia, preventing or postponing the onset of AD and delaying or slowing its progression are becoming mandatory. Among possible reversible risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors were associated with the development of dementia and late-life cognitive disorders, opening new avenues for the prevention of these diseases...
March 2015: Journal of Nutrition, Health & Aging
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