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Metabolically healthy obese

Meena Balasubramanian, Diana S Johnson
BACKGROUND: Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases due to impaired lipid and protein glycosylation. It comprises a characteristic high frequency of intellectual disability (ID) and a wide range of clinical phenotypes. OBJECTIVE: (s): To identify the underlying diagnosis in two families each with two siblings with variable level of ID through trio whole exome sequencing. METHODS: Both the families were recruited to the Deciphering Developmental Disorders (DDD) study to identify the aetiology for their ID...
June 13, 2018: European Journal of Medical Genetics
Dhite Bayu Nugroho, Koji Ikeda, Agian Jeffilano Barinda, Donytra Arby Wardhana, Keiko Yagi, Keishi Miyata, Yuichi Oike, Ken-Ichi Hirata, Noriaki Emoto
Adipose tissue (AT) contains well-developed vascular networks. Pathological AT expansion often accompany the reduction in AT blood vessels, which further exacerbates adipocyte dysfunction due to hypoxia; however, it remains unclear whether AT vascular rarefaction is simply secondary to adipocyte hypertrophy, or if there is an actively regulated pathway that mediates impaired AT angiogenesis in obesity. We searched for growth factors whose expression in AT is down-regulated in obesity; accordingly, we identified neuregulin-4 (Nrg4), a member of the EGF family of proteins...
June 11, 2018: Biochemical and Biophysical Research Communications
Mikkel Lykke, Per T Sangild, Johannes B van Goudoever, Dewi van Harskamp, Henk Schierbeek, Berthold Koletzko, Eline M van der Beek, Marieke Abrahamse-Berkeveld, Bert J M van de Heijning, Barbara Stoll, Douglas G Burrin, Thomas Thymann
Background: Excess protein intake in early life has been linked to obesity and metabolic syndrome in later life. Yet protein, and in particular the essential amino acids (EAAs), need to be present in adequate quantity to support growth. Objective: With the use of a piglet model restricted in dietary amino acids (AAs), we compared the efficacy and safety of a standard formula with a low-AA formula containing an adjusted AA composition. Methods: Female piglets (3-7 d old; Landrace × Yorkshire × Duroc) were fed 1 of 4 isoenergetic AA-based formulas for 14 d (700 kJ · kg body weight-1 · d-1)...
May 13, 2018: Journal of Nutrition
Amany K Elshorbagy, Dorit Samocha-Bonet, Fredrik Jernerén, Cheryl Turner, Helga Refsum, Leonie K Heilbronn
Background: Plasma concentrations of branched-chain amino acids (BCAAs) and the sulfur-containing amino acid cysteine are associated with obesity and insulin resistance. BCAAs predict future diabetes. Objective: We investigated amino acid changes during food overconsumption. Methods: Forty healthy men and women with a body mass index (mean ± SEM) of 25.6 ± 0.6 were overfed by 1250 kcal/d for 28 d, increasing consumption of all macronutrients...
June 13, 2018: Journal of Nutrition
Claire Greenhill
No abstract text is available yet for this article.
June 13, 2018: Nature Reviews. Endocrinology
F T Fellendorf, M Platzer, R Pilz, A Rieger, H P Kapfhammer, H Mangge, N Dalkner, S Zelzer, A Meinitzer, A Birner, S A Bengesser, R Queissner, C Hamm, R Hartleb, E Z Reininghaus
OBJECTIVES: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. METHODS: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analyzed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters...
June 14, 2018: World Journal of Biological Psychiatry
Marhazlina Mohamad, See Ling Loy, Poh Ying Lim, Yu Wang, Kah Leng Soo, Hamid Jan Jan Mohamed
The prevalence of childhood obesity is increasing at an alarming rate in Malaysia. Metabolic changes during pregnancy are critical to the development of infant adiposity, due to imbalanced adipokines production. Hence, we aimed to investigate the association of maternal serum and breast milk adipokines with infant adiposity development. The study was conducted from April 2010 until December 2012. A total of 155 healthy pregnant mothers aged 19 to 40 years were recruited during the first and second trimester in Kelantan, Malaysia...
June 12, 2018: International Journal of Environmental Research and Public Health
Magali Palau-Rodriguez, Sara Tulipani, Anna Marco-Ramell, Antonio Miñarro, Olga Jáuregui, Raúl González-Domínguez, Alex Sanchez-Pla, Bruno Ramos-Molina, Francisco J Tinahones, Cristina Andres-Lacueva
The exact impact of bariatric surgery in metabolically "healthy" (MH) or "unhealthy" (MU) phenotypes for the study of the metabolic improvement is still unknown. We applied an untargeted LC-ESI-TripleTOF -MS- driven metabolomics approach in serum samples from 39 patients with morbid obesity (MH and MU) 1, 3 and 6 months after bariatric surgery. Multiple factor analysis, along with correlation and enrichment analyses were carried out to distinguish those metabolites associated with metabolic improvement...
June 12, 2018: Journal of Proteome Research
Farshad Farzadfar, Abolghasem Djazayery, Lu Qi, Minoo Bagheri, Mir Saeed Yekaninejad, Maryam Chamari, Maryam Naderi, Zarin Ebrahimi, Berthold Koletzko, Olaf Uhl
BACKGROUND: Uncertainty remains about the effect of vitamin D therapy on biomarkers of health status in obesity. The molecular basis underlying this controversy is largely unknown. OBJECTIVE: To address the existing gap, our study sought to compare changes in metabolomic profiles of obesity phenotypes (metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO)) patients with sub-optimal levels of vitamin D following vitamin D supplementation. METHODS: We conducted two randomized double-blind clinical trials on participants with either of the two obesity phenotypes from Tehran province...
June 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Myong Ki Baeg, Sun-Hye Ko, Seung Yeon Ko, Hee Sun Jung, Myung-Gyu Choi
BACKGROUND: Obesity is a known risk factor for erosive esophagitis (EE) and metabolic unhealthiness has been implicated in EE pathogenesis. However, obesity and metabolic unhealthiness are not synonymous and the associations between obesity, metabolic health, and EE are unclear. Therefore, our aim was to investigate the relationship between EE, obesity, and metabolic health. METHODS: We performed a retrospective cross-sectional study of subjects undergoing health screening at a university hospital...
June 8, 2018: BMC Gastroenterology
Eun Sun Yoon, Kevin S Heffernan, Sae Young Jae, Hyun Jeong Kim, Kanokwan Bunsawat, Bo Fernhall
OBJECTIVE: Despite preserved metabolic function, metabolically healthy obesity may increase the risk of subclinical atherosclerosis. Given the high prevalence of cardiometabolic diseases in individuals with spinal cord injury, the aim of this study was to investigate the association of insulin resistance, systemic low-grade inflammation, and markers of subclinical atherosclerosis with metabolically healthy obesity in individuals with spinal cord injury. METHODS: Insulin resistance index (HOMA-IR), high-sensitivity C-reactive protein, carotid artery intima-media thickness and carotid-femoral pulse wave velocity were measured in individuals with spinal cord injury classified with metabolically healthy obesity (n = 12), metabolically unhealthy obesity (n = 8), or metabolically healthy normal-weight (n = 18)...
June 8, 2018: Journal of Rehabilitation Medicine
Paolo Bordin, Francesca Picco, Francesca Valent, Bruna Mattiussi, Luigino Vidotto, Giorgio Brianti
AIMS: Cardio50 is a project of active risk identification and cardiovascular prevention implemented in an Italian cohort of healthy people aged 50. METHODS: A total of 3127 individuals were invited for a screening visit with lifestyle interview and registration of BMI, blood pressure (BP), glucose, cholesterol and classified into groups: A (normal), B (abnormal lifestyle, normal parameters), C (at least one abnormal parameter). People in group C were offered a free blood test and a specialistic medical visit to investigate the suspect of hypertension, dyslipidemia or dysglycemia...
June 6, 2018: Journal of Cardiovascular Medicine
Enrique Almanza-Aguilera, Carl Brunius, M Rosa Bernal-Lopez, Mar Garcia-Aloy, Francisco Madrid-Gambin, Francisco J Tinahones, Ricardo Gómez-Huelgas, Rikard Landberg, Cristina Andres-Lacueva
Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analysed using an untargeted 1H-NMR metabolomics approach at baseline, after 3 months (intervention) and 12 months (follow-up)...
June 7, 2018: Journal of Proteome Research
Ji Taek Hong, Tae Jun Kim, Jeung Hui Pyo, Eun Ran Kim, Sung Noh Hong, Young-Ho Kim, Hyeon Seon Ahn, Insuk Sohn, Dong Kyung Chang
BACKGROUND AND AIM: Sarcopenia is a pathological condition characterized by the progressive loss of muscle mass and increased amount of visceral fat. Recent evidence has revealed that sarcopenia is associated with certain diseases. However, the impact of sarcopenia on colorectal neoplasia has not been documented clearly. We studied the association between sarcopenia and advanced colorectal neoplasia in a large screening population. METHODS: This cross-sectional study included 14,024 asymptomatic adults who underwent first-time screening colonoscopy...
June 7, 2018: Journal of Gastroenterology and Hepatology
Anna Babinska, Mariusz Kaszubowski, Krzysztof Sworczak
Due to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic syndrome was demonstrated. The aim of the study was to investigate plasma adiponectin, leptin, resistin, tumor necrosis factor α (TNFα), interleukin 6 (IL6) and monocyte chemoattractant protein 1 (MCP1) levels in patients with NFAIs and healthy subjects...
June 5, 2018: Endocrine Journal
Catherine Nduku Kiama, Joyce Njeri Wamicwe, Elvis Omondi Oyugi, Mark Odhiambo Obonyo, Jane Githuku Mungai, Zeinab Gura Roka, Ann Mwangi
Introduction: Metabolic syndrome affects 20-25% of the adult population globally. It predisposes to cardiovascular disease and Type 2 diabetes. Studies in other countries suggest a high prevalence of metabolic syndrome among HIV-infected patients but no studies have been reported in Kenya. The objective of this study was to assess the prevalence and factors associated with metabolic syndrome in adult HIV-infected patients in an urban population in Nairobi, Kenya. Methods: In a cross-sectional study design, conducted at Riruta Health Centre in 2016, 360 adults infected with HIV were recruited...
2018: Pan African Medical Journal
Bing Cao, Yan Chen, Elisa Brietzke, Danielle Cha, Aisha Shaukat, Zihang Pan, Caroline Park, Mehala Subramaniapillai, Hannah Zuckerman, Kiran Grant, Rodrigo B Mansur, Roger S McIntyre
OBJECTIVES: To explore differences in adipokine levels (i.e., leptin and adiponectin levels) between adults with Major Depressive Disorder (MDD) and healthy controls (HC), and to discuss the possible role of adipokine regulation in the development and progression of MDD. METHODS: A systematic review and meta-analysis were conducted based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. A systematic search was conducted for all English and Chinese peer-reviewed articles from inception to November 2017...
June 2, 2018: Journal of Affective Disorders
Ty T Kim, Nirmal Parajuli, Miranda M Sung, Suresh C Bairwa, Jody Levasseur, Carrie-Lynn M Soltys, David S Wishart, Karen Madsen, Jonathan D Schertzer, Jason R B Dyck
Oral administration of resveratrol attenuates several symptoms associated with the metabolic syndrome such as impaired glucose homeostasis and hypertension. Recent work has shown that resveratrol can improve glucose homeostasis in obesity via changes in the gut microbiota. Studies involving fecal microbiome transplants (FMTs) suggest that either live gut microbiota or bacterial-derived metabolites from resveratrol ingestion are responsible for producing the observed benefits in recipients. Herein, we show that obese mice receiving FMTs from healthy resveratrol-fed mice have improved glucose homeostasis within 11 days of the first transplant, and that resveratrol-FMTs is more efficacious than oral supplementation of resveratrol for the same duration...
June 5, 2018: American Journal of Physiology. Endocrinology and Metabolism
Natalie Kirch, Lea Berk, Yvonne Liegl, Marcel Adelsbach, Benno F Zimmermann, Peter Stehle, Birgit Stoffel-Wagner, Norbert Ludwig, Andreas Schieber, Hans-Peter Helfrich, Sabine Ellinger
Background: Regular cocoa consumption has been shown to reduce blood pressure, improve lipid profiles, and increase insulin sensitivity and flow-mediated dilatation in healthy adults. It is assumed that these effects can be attributed to polyphenolic cocoa ingredients such as flavanols, especially to (-)-epicatechin. Nutritive intervention studies to prove this hypothesis are scarce. Objective: We aimed to evaluate whether regular consumption of 25 mg of pure (-)-epicatechin can affect increased cardiometabolic risk factors [blood pressure, glucose and lipid metabolism, low-density lipoprotein (LDL) oxidation] in overweight-to-obese subjects...
June 1, 2018: American Journal of Clinical Nutrition
Izaskun Garcia-Mantrana, Marta Selma-Royo, Cristina Alcantara, María C Collado
There is increasing evidence for the interaction between gut microbiome, diet, and health. It is known that dysbiosis is related to disease and that most of the times this imbalances in gut microbial populations can be promoted through diet. Western dietary habits, which are characterized by high intakes of calories, animal proteins, saturated fats, and simple sugars have been linked with higher risk of obesity, diabetes, cancer, and cardiovascular disease. However, little is known about the impact of dietary patterns, dietary components, and nutrients on gut microbiota in healthy people...
2018: Frontiers in Microbiology
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