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Metabolically healthy obese

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https://www.readbyqxmd.com/read/29447114/higher-d-lactate-levels-are-associated-with-higher-prevalence-of-small-dense-low-density-lipoprotein-in-obese-adolescents
#1
Reyna Rodríguez-Mortera, Claudia Luevano-Contreras, Sergio Solorio-Meza, Russell Caccavello, Yasmin Bains, Ma Eugenia Garay-Sevilla, Alejandro Gugliucci
BACKGROUND: Childhood obesity is associated with insulin resistance (IR), increased levels of small dense low-density lipoprotein (sd-LDL) as well as with augmented hepatic de novo lipogenesis, which implies increased triose phosphate fluxes that may lead to increased methylglyoxal (MG) and its catabolic end product D-lactate. We hypothesized that obese adolescents have increased D-lactate serum levels associated with high incidence of sd-LDL. METHODS: This is a cross-sectional study where the anthropometric characteristics, atherogenic dyslipidemia complex, sd-LDL (Lipoprint, Quantimetrix) and D-lactate (kinetic enzymatic analysis) were explored in 30 lean vs...
February 15, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29444663/gender-related-differences-in-cardiometabolic-risk-factors-and-lifestyle-behaviors-in-treatment-seeking-adolescents-with-severe-obesity
#2
Lisa Ha Barstad, Pétur B Júlíusson, Line Kristin Johnson, Jens Kristoffer Hertel, Samira Lekhal, Jøran Hjelmesæth
BACKGROUND: Obesity during adolescence is associated with cardiovascular mortality in adulthood. The adverse obesity-related cardiometabolic risk profile is already observed in adolescence. We aimed to examine possible gender differences in cardiometabolic risk factors and lifestyle behaviors among adolescents with severe obesity, hypothesizing that boys would have both a higher prevalence of the metabolic syndrome as well as less healthy lifestyle behaviors than girls. METHODS: Cross-sectional study of treatment-seeking adolescents with severe obesity who attended the Morbid Obesity Centre at Vestfold Hospital Trust and who were consecutively enrolled in the Vestfold Register of Obese Children between September 2009 and September 2015...
February 14, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29440783/comparative-analysis-of-subgingival-red-complex-bacteria-in-obese-and-normal-weight-subjects-with-and-without-chronic-periodontitis
#3
Snophia Suresh, Jaideep Mahendra, Angabakkam Rajasekaran Pradeep Kumar, Gurdeep Singh, Selvaraj Jayaraman, Roshini Paul
Background: Obesity is one of the systemic conditions which influence the onset and progression of periodontal disease and it is stated that the metabolic changes associated with obesity may contribute to alteration in subgingival microbial flora. Aim: Our study was aimed to quantify and compare the red complex microorganisms in obese or overweight and normal weight participants with and without chronic periodontitis to identify obesity as a risk for the presence of red complex bacteria...
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29437994/metabolic-profiling-of-visceral-adipose-tissue-from-obese-subjects-with-or-without-metabolic-syndrome
#4
Eleonora Candi, Manfredi Tesauro, Carmine Cardillo, Anna Maria Lena, Francesca Schinzari, Giuseppe Rodia, Giuseppe Sica, Paolo Gentileschi, Valentina Rovella, Margherita Annicchiarico-Petruzzelli, Nicola Di Daniele, Gerry Melino
Obesity represents one of the most complex public health challenges and has recently reached epidemic proportions.  Obesity is also considered to be primarily responsible for the rising prevalence of metabolic syndrome, defined as the coexistence in the same individual of several risk factors for atherosclerosis, including dyslipidaemia, hypertension and hyperglycaemia, as well as for cancer. Additionally, the presence of three of the five risk factors (abdominal obesity, low HDL cholesterol, high triglycerides, high fasting glucose and high blood pressure) characterizes metabolic syndrome, which has serious clinical consequences...
February 8, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29437024/uric-acid-metabolic-syndrome-and-atherosclerosis-the-chicken-or-the-egg-which-comes-first
#5
Giovanni De Pergola, Francesca Cortese, Gaetano Termine, Giovanni Meliota, Michele Masiello, Anna Maria Cortese, Francesco Silvestris, Domenico Caccavo, Marco Matteo Ciccone
BACKGROUND: A great debate in literature exists nowadays on the role of uric acid as a marker of cardiovascular and metabolic organ damage or a risk factor for cardiovascular and metabolic disease. METHODS: to determine the relationship among serum uric acid and metabolic syndrome and atherosclerosis, by mean of carotid intima media-thickness, in a cohort of 811 otherwise healthy overweight/obese subjects, without overt atherosclerosis not using any kind of drug...
February 11, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29436736/psychological-stress-induced-cerebrovascular-dysfunction-the-role-of-metabolic-syndrome-and-exercise
#6
Steven Brooks, Kayla Branyan, Evan DeVallance, Roy Skinner, Kent Lemaster, J Whitney Sheets, Christopher R Pitzer, Shinichi Asano, Randall Bryner, I Mark Olfert, Jefferson C Frisbee, Paul D Chantler
Chronic unresolvable stress leads to the development of depression and cardiovascular disease (CVD). There is a high prevalence of depression with the metabolic syndrome (MetS), however, to what extent the MetS concurrent with psychological stress affects cerebrovascular function is unknown. We investigated the differential effect of MetS on cerebrovascular structure/function in rats (16-17-wk-old) following 8 wk of unpredictable chronic mild stress (UCMS), and whether exercise training could limit any cerebrovascular dysfunction...
February 13, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29435121/lipidomics-reveals-altered-biosynthetic-pathways-of-glycerophospholipids-and-cell-signaling-as-biomarkers-of-the-polycystic-ovary-syndrome
#7
Mariona Jové, Irene Pradas, Alba Naudí, Susana Rovira-Llopis, Celia Bañuls, Milagros Rocha, Manuel Portero-Otin, Antonio Hernández-Mijares, Victor M Victor, Reinald Pamplona
Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors such as dyslipemia, obesity, altered glucose/insulin metabolism, cardiovascular disease, or cancer. Results: Multivariate statistics revealed a specific lipidomic signature for PCOS patients without associated pathologies. This signature implies changes, mainly by down-regulation, in glycerolipid, glycerophospholipid and sphingolipid metabolism suggesting an altered biosynthetic pathway of glycerophospholipids and cell signaling as second messengers in women with PCOS...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29433580/dietary-patterns-and-physical-activity-in-the-metabolically-un-healthy-obese-the-dutch-lifelines-cohort-study
#8
Sandra N Slagter, Eva Corpeleijn, Melanie M van der Klauw, Anna Sijtsma, Linda G Swart-Busscher, Corine W M Perenboom, Jeanne H M de Vries, Edith J M Feskens, Bruce H R Wolffenbuttel, Daan Kromhout, Jana V van Vliet-Ostaptchouk
BACKGROUND: Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences in dietary patterns and physical activity between MHO and metabolically unhealthy obesity (MUO). METHODS: Cross-sectional data of 9270 obese individuals (30-69 years) of the Lifelines Cohort Study was used. MHO was defined as obesity and no metabolic syndrome risk factors and no cardiovascular disease history...
February 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29430577/phenotypic-and-metabolic-dichotomy-in-obesity-clinical-biochemical-and-immunological-correlates-of-metabolically-divergent-obese-phenotypes-in-healthy-south-asian-adults
#9
Khadija Irfan Khawaja, Saqib Ali Mian, Aziz Fatima, Ghulam Murtaza Tahir, Fehmida Farrukh Khan, Saira Burney, Ali Hasan, Faisal Masud
INTRODUCTION: Metabolic heterogeneity among obese individuals is thought to translate into variation in cardiovascular risk. Identifying obese people with an unfavourable metabolic profile may allow targeting preventive strategies towards those at greatest risk. This study aimed to identify clinical, biochemical and immunological differences between insulin sensitive and resistant obese subgroups, to understand the population-specific pathophysiological basis of the adverse cardiovascular risk profile in the latter group...
February 12, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29429331/investigation-of-lipid-metabolism-by-a-new-structured-lipid-with-medium-and-long-chain-triacylglycerols-from-cinnamomum-camphora-seed-oil-in-healthy-c57bl-6j-mice
#10
Jiang-Ning Hu, Jin-Rong Shen, Chao-Yue Xiong, Xue-Mei Zhu, Ze-Yuan Deng
In the present study, a new structured lipid with medium- and long-chain triacylglycerols (MLCTs) was synthesized from camellia oil (CO) and Cinnamomum camphora seed oil (CCSO) by enzymatic interesterification. Meanwhile, the antiobesity effects of structured lipid were investigated through observing the changes of enzymes related to lipid mobilization in healthy C57BL/6J mice. Results showed that after synthesis, the major triacylgeride (TAG) species of intesterificated product changed to LaCC/CLaC (12.6 ± 0...
February 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29428931/increased-expression-of-the-innate-immune-receptor-tlr10-in-obesity-and-type-2-diabetes-association-with-ros-mediated-oxidative-stress
#11
Sardar Sindhu, Nadeem Akhter, Shihab Kochumon, Reeby Thomas, Ajit Wilson, Steve Shenouda, Jaakko Tuomilehto, Rasheed Ahmad
BACKGROUND/AIMS: Metabolic diseases such as obesity and type-2 diabetes (T2D) are known to be associated with chronic low-grade inflammation called metabolic inflammation together with an oxidative stress milieu found in the expanding adipose tissue. The innate immune Toll-like receptors (TLR) such as TLR2 and TLR4 have emerged as key players in metabolic inflammation; nonetheless, TLR10 expression in the adipose tissue and its significance in obesity/T2D remain unclear. METHODS: TLR10 gene expression was determined in the adipose tissue samples from healthy non-diabetic and T2D individuals, 13 each, using real-time RT-PCR...
January 30, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29428927/dancing-for-healthy-aging-functional-and-metabolic-perspectives
#12
Josianne Rodrigues-Krause, Mauricio Krause, Alvaro Reischak-Oliveira
Context • Dancing has been used as a form of exercise to improve functional and metabolic outcomes during aging. The field lacks randomized, clinical trials (RCTs) evaluating metabolic outcomes related to dance interventions, but dancing may be a form of exercise that could induce positive effects on the metabolic health of older adults. However, primary studies seem very heterogonous regarding the trial designs, characteristics of the interventions, the methods for outcomes assessments, statistical powers, and methodological quality...
February 10, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29425657/urine-metabolomics-shows-an-induction-of-fatty-acids-metabolism-in-healthy-adult-volunteers-after-supplementation-with-green-coffee-coffea-robusta-l-bean-extract
#13
Gregorio Peron, Davide Santarossa, Dario Voinovich, Stefano Dall'Acqua, Stefania Sut
BACKGROUND AND OBJECTIVE: Green coffee bean extract is used as herbal medicine or supplement for weight reduction and obesity. The active constituents are considered caffeine and chlorogenic acid (CGA) derivatives. The mode of action of CGA is still unclear and can be related to peroxisome proliferator-activated receptor α (PPAR-α) and liver X receptor Rα (LXR-α). Metabolomics may be an innovative tool for the description and discovery of the multiple target nature of such phytocomplex...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29423219/the-effect-of-protein-supplementation-on-body-muscle-mass-and-fat-mass-in-post-bariatric-surgery-a-randomized-controlled-trial-rct-study-protocol
#14
Sahar D Al-Shamari, Mohamed Aly ElSherif, Wahiba Hamid, Fahad Hanna
Background: Severe weight loss through means of bariatric surgery has been associated with loss of muscle mass due to lack of absorption of protein. The aim of this RCT is to investigate the effectiveness of protein supplementation in reducing the risk of developing protein malnutrition and muscle wasting in post-bariatric surgery patients in Qatar. Methods and analysis: The study was based at the Department of bariatric and metabolic surgery, Doha metropolitan and regional areas...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29417469/association-between-systemic-leptin-and-neurotensin-concentration-in-adult-individuals-with-and-without-type-2-diabetes-mellitus
#15
I Barchetta, G Ciccarelli, F A Cimini, V Ceccarelli, M Orho-Melander, O Melander, M G Cavallo
PURPOSE: Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed in human intestine where it promotes fat absorption and its circulating levels associate with obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease. Whether a relation exists between circulating leptin and NT levels has not been investigated yet. The aim of this study was to test the hypothesis of an association between plasma leptin and NT concentration in adults with or without T2DM...
February 7, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29416552/fructo-oligosaccharides-and-glucose-homeostasis-a-systematic-review-and-meta-analysis-in-animal-models
#16
REVIEW
Cindy Le Bourgot, Emmanuelle Apper, Sophie Blat, Frédérique Respondek
The aim of this systematic review was to assess the effect of fructo-oligosaccharide supplementation on glucose homeostasis. The search process was based on the selection of publications listed in the Pubmed-Medline database until April 2016 to identify studies evaluating the impact of short-chain fructo-oligosaccharides or oligofructose on glucose homeostasis. Twenty-nine trials were included in the systematic review and the meta-analysis was performed on twelve of these papers according to the inclusion criteria...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29410981/diet-and-microbiota-linked-in-health-and-disease
#17
REVIEW
T Requena, M C Martínez-Cuesta, C Peláez
Diet has shaped microbiota profiles through human evolution. Traditional gut microbiomes are described to be driven by high levels of Prevotella. In the present, however, it is consistently described a lower microbial richness in urban industrialized populations compared with individuals living in rural settings, Bacteroides being predominant among urban-industrial gut microbiomes. Components of diet are highly influential in shaping the gut microbiota, being fiber, fat, proteins, polyphenols and micronutrients differentially metabolized by generalist and specialized microorganisms alone or through the phenomenon of cross-feeding...
February 7, 2018: Food & Function
https://www.readbyqxmd.com/read/29410303/association-of-leptin-adiponectin-ratio-and-metabolic-risk-markers-in-postmenopausal-women
#18
Vandana Gupta, Sameeksha Mishra, Supriya Mishra, Sandeep Kumar, Vani Gupta
Leptin and adiponectin play an important role in the regulation of body weight and energy homeostasis. The purpose of the present study was to ascertain the relationship between leptin to adiponectin ratio (L:A) and metabolic risk factors in postmenopausal women.This is a cross sectional case-control study. A total of 523 postmenopausal women were recruited for the study 270 postmenopausal women with metabolic syndrome and 253 apparently healthy control postmenopausal women without metabolic syndrome. Biochemical and Anthropometrical parameters were measured...
February 2, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29402762/effect-on-the-metabolic-biomarkers-in-schoolchildren-after-a-comprehensive-intervention-using-electronic-media-and-in-person-sessions-to-change-lifestyles-community-trial
#19
Jenny Vilchis-Gil, Miguel Klünder-Klünder, Samuel Flores-Huerta
BACKGROUND: Obesity is a chronic low-intensity state of inflammation with metabolic alterations that, when acquired during childhood, lead to severe illness in adults. Encouraging healthy eating habits and physical activity is the basis for preventing and treating obesity and its complications. OBJECTIVE: To evaluate how a comprehensive intervention promoting healthy eating habits and physical activities in schools affects children's metabolic biomarkers. METHODS: Of four Mexico City primary schools in this study, two groups of children that were recruited at their schools were assigned to a 12-month intervention group (IG) and the other two were assigned to control groups (CGs)...
February 5, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29401650/the-role-of-the-japanese-traditional-diet-in-healthy-and-sustainable-dietary-patterns-around-the-world
#20
Ana San Gabriel, Kumiko Ninomiya, Hisayuki Uneyama
As incomes steadily increase globally, traditional diets have been displaced by diets that are usually animal-based with a high content of "empty calories" or refined sugars, refined fats, and alcohol. Dietary transition coupled with the expansion of urbanization and lower physical activity have been linked to the global growth in the prevalence of obesity, overweight and life style-related non-communicable diseases. The challenge is in how to reverse the trend of high consumption of less healthy food by more healthful and more environmentally sustainable diets...
February 3, 2018: Nutrients
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