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https://www.readbyqxmd.com/read/29692737/spexin-acts-as-novel-regulator-for-bile-acid-synthesis
#1
Cheng-Yuan Lin, Ling Zhao, Tao Huang, Lin Lu, Mahjabin Khan, Jie Liu, Linda L D Zhong, Zong-Wei Cai, Bao-Min Fan, Anderson O L Wong, Zhao-Xiang Bian
Spexin is a novel hormone involved in obesity and diabetes while its biofunctional significance in lipid metabolism is still to be comprehended. Global metabolomic analysis in the present study revealed multiple metabolic pathways altered by spexin intraperitoneal ( i.p .) injection in rat serum, which are highlighted by the changes in several bile acid metabolites. In rats, spexin (300 μg/kg) could dramatically reduce hepatic and circulating total bile acids (TBA) level compared with the controls. Correspondingly, treatment with spexin by i...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29691953/circulating-mots-c-levels-are-decreased-in-obese-male-children-and-adolescents-and-associated-with-insulin-resistance
#2
Caiqi Du, Cai Zhang, Wei Wu, Yan Liang, Anru Wang, Shimin Wu, Yue Zhao, Ling Hou, Qin Ning, Xiaoping Luo
BACKGROUND AND AIMS: A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted attention as a potential prevention or therapeutic option for obesity and type 2 diabetes mellitus (T2DM). MOTS-c profiles have not yet been reported in human obesity and T2DM. We aimed to determine circulating MOTS-c levels in obesity and explore the association between MOTS-c levels and various metabolic parameters. METHODS: In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017...
April 25, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29687092/circulating-spexin-levels-negatively-correlate-with-age-bmi-fasting-glucose-and-triglycerides-in-healthy-adult-women
#3
Cheng-Yuan Lin, Tao Huang, Ling Zhao, Linda L D Zhong, Wai Ching Lam, Bao-Min Fan, Zhao-Xiang Bian
Context: Spexin is a newly identified neuropeptide that is involved in satiety control, glucose, and lipids metabolism. It has also been related to human diseases, such as obesity and type 2 diabetes. However, whether spexin changes with age or not is still unclear. Objective: The aim of this study is to investigate the relationship between circulating spexin levels and age and to study their interaction effects on body mass index (BMI), fasting glucose, and -lipids...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29684673/exercise-as-a-therapeutic-intervention-to-optimize-fetal-weight
#4
REVIEW
Laura M Reyes, Margie H Davenport
The Developmental Origins of Health and Disease suggest the in utero environment programs offspring obesity and cardiovascular disease. Therefore, there is a need to implement safe therapeutic interventions that do not involve the intake of medications or biological products during pregnancy that can improve maternal and fetal health. Prenatal exercise is established to promote maternal and fetal health. It is generally recommended that women accumulate at least 150 minutes per week of moderate-intensity exercise...
April 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29680861/obesity-and-metabolic-features-associated-with-long-term-developing-diastolic-dysfunction-in-an-initially-healthy-population-based-cohort
#5
Kénora Chau, Nicolas Girerd, Martin Magnusson, Zohra Lamiral, Erwan Bozec, Ludovic Merckle, Margret Leosdottir, Erasmus Bachus, Zied Frikha, João Pedro Ferreira, Jean-Pierre Després, Patrick Rossignol, Jean-Marc Boivin, Faiez Zannad
BACKGROUND: Diastolic dysfunction (DD) is increasingly common. However, its metabolic determinants are poorly known. This study aims to determine which metabolic and inflammatory features predict DD in initially healthy adults. METHODS: We prospectively analyzed the association between metabolic features and DD in 728 initially healthy adults aged 30-60 from Eastern France enrolled in the STANISLAS population-based cohort. Clinical and biological cardiovascular features were collected at baseline (1994-1995)...
April 21, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29675621/myocardial-function-in-primary-antiphospholipid-syndrome-using-speckle-tracking-echocardiography
#6
Gabriela Medina, Eduardo Gómez-Bañuelos, Erick Calderón-Aranda, María Pilar Cruz-Domínguez, Olga Vera-Lastra, Luis J Jara
Antiphospholipid syndrome (APS) patients have high cardiovascular risk. Speckle-tracking echocardiography (STE) detects myocardial function. To evaluate the myocardial function in primary APS (PAPS) patients using two-dimensional echocardiography (2-D) obtaining values of left ventricle global longitudinal strain (GLS) by STE. Patients with PAPS, > 16 years, both genders, without signs and symptoms of heart disease were recruited and matched with healthy controls by age and gender. Demographic, clinical data, and cardiovascular risk factors were recorded...
April 19, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29674996/association-between-thyroid-hormones-thyroid-antibodies-and-cardiometabolic-factors-in-non-obese-individuals-with-normal-thyroid-function
#7
Jia Liu, Yan Duan, Jing Fu, Guang Wang
Background: Hypothyroidism is an important risk factor for cardiovascular diseases, and autoimmune thyroiditis (AIT) is the leading cause of hypothyroidism. Recent studies showed that even AIT patients with euthyroidism still had an increased number of early atherosclerotic lesions. However, the precise mechanism is not yet known. This study aimed to investigate the association of thyroid function, thyroid autoimmunity, and cardiometabolic risk factors in non-obese AIT patients with euthyroidism...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29674968/peripherally-administered-y-2-receptor-antagonist-biie0246-prevents-diet-induced-obesity-in-mice-with-excess-neuropeptide-y-but-enhances-obesity-in-control-mice
#8
Liisa Ailanen, Laura H Vähätalo, Henriikka Salomäki-Myftari, Satu Mäkelä, Wendy Orpana, Suvi T Ruohonen, Eriika Savontaus
Neuropeptide Y (NPY) plays an important role in the regulation of energy homeostasis in the level of central and sympathetic nervous systems (SNSs). Genetic silencing of peripheral Y2 -receptors have anti-obesity effects, but it is not known whether pharmacological blocking of peripheral Y2 -receptors would similarly benefit energy homeostasis. The effects of a peripherally administered Y2 -receptor antagonist were studied in healthy and energy-rich conditions with or without excess NPY. Genetically obese mice overexpressing NPY in brain noradrenergic nerves and SNS (OE-NPYDβH ) represented the situation of elevated NPY levels, while wildtype (WT) mice represented the normal NPY levels...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29673211/the-role-of-gut-microbiota-in-obesity-and-type-2-and-type-1-diabetes-mellitus-new-insights-into-old-diseases
#9
REVIEW
Igor Alexander Harsch, Peter Christopher Konturek
The investigation of the human microbiome is the most rapidly expanding field in biomedicine. Early studies were undertaken to better understand the role of microbiota in carbohydrate digestion and utilization. These processes include polysaccharide degradation, glycan transport, glycolysis, and short-chain fatty acid production. Recent research has demonstrated that the intricate axis between gut microbiota and the host metabolism is much more complex. Gut microbiota—depending on their composition—have disease-promoting effects but can also possess protective properties...
April 17, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29664676/a-mathematical-analysis-of-adaptations-to-the-metabolic-fate-of-fructose-in-essential-fructosuria-subjects
#10
R J Allen, Cynthia J Musante
Fructose is a major component of Western diets and is implicated in the pathogenesis of obesity and type 2 diabetes. In response to an oral challenge, the majority of fructose is cleared during "first-pass" liver metabolism, primarily via phosphorylation by ketohexokinase (KHK). A rare benign genetic deficiency in KHK, called essential fructosuria (EF), leads to altered fructose metabolism. The only reported symptom of EF is the appearance of fructose in the urine following either oral or intravenous fructose administration...
April 17, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29659960/obese-mice-losing-weight-due-to-trans-10-cis-12-conjugated-linoleic-acid-supplementation-or-food-restriction-harbor-distinct-gut-microbiota
#11
Laura J den Hartigh, Zhan Gao, Leela Goodspeed, Shari Wang, Arun K Das, Charles F Burant, Alan Chait, Martin J Blaser
Background: trans-10,cis-12 Conjugated linoleic acid (t10,c12-CLA) is a dietary supplement that promotes weight loss by increasing fat oxidation and energy expenditure. We previously reported that in the absence of t10,c12-CLA, mice forced to lose equivalent body weight by food restriction (FR) do not exhibit increases in fat oxidation or energy expenditure but have improved glucose metabolism, consistent with FR as a metabolically healthy weight-loss method. Objective: Because diet is a primary determinant of gut bacterial populations, we hypothesized that the disparate metabolic effects accompanying weight loss from t10,c12-CLA or FR could be related to altered intestinal microbiota...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659954/the-ossabaw-pig-is-a-suitable-translational-model-to-evaluate-dietary-patterns-and-coronary-artery-disease-risk
#12
Nirupa R Matthan, Gloria Solano-Aguilar, Huicui Meng, Stefania Lamon-Fava, Audrey Goldbaum, Maura E Walker, Saebyeol Jang, Sukla Lakshman, Aleksey Molokin, Yue Xie, Ethiopia Beshah, James Stanley, Joseph F Urban, Alice H Lichtenstein
Background: Animal models that mimic diet-induced human pathogenesis of chronic diseases are of increasing importance in preclinical studies. The Ossabaw pig is an established model for obesity-related metabolic disorders when fed extreme diets in caloric excess. Objective: To increase the translational nature of this model, we evaluated the effect of diets resembling 2 human dietary patterns, the Western diet (WD) and the Heart Healthy Diet (HHD), without or with atorvastatin (-S or +S) therapy, on cardiometabolic risk factors and atherosclerosis development...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29658358/association-of-mthfr-c677t-gene-polymorphism-with-metabolic-syndrome-in-a-chinese-population-a-case-control-study
#13
Jin Wang, Lijuan Xu, Hongmiao Xia, Ying Li, Shiqi Tang
Objective To investigate the association of the MTHFR C677T gene polymorphism with metabolic syndrome (MetS) in people in Hubei Province, China. Methods A case-control study was conducted with 651 subjects with MetS (MetS group) and 727 healthy controls (control group) at Renmin Hospital of Wuhan University between January and December 2016. The MTHFR C677T genotype was detected by the gene chip technique and clinical data were collected. Results Body mass index, waist circumference, the waist-hip-ratio, systolic and diastolic blood pressure, fasting blood glucose, fasting insulin, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, and homocysteine levels, and the homeostasis model assessment of insulin resistance were higher in the MetS group than in controls...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29656108/epoxygenase-inactivation-exacerbates-diet-and-aging-associated-metabolic-dysfunction-resulting-from-impaired-adipogenesis
#14
Antoni Olona, Ximena Terra, Jeong-Hun Ko, Carme Grau-Bové, Montserrat Pinent, Anna Ardevol, Ana Garcia Diaz, Aida Moreno-Moral, Matthew Edin, David Bishop-Bailey, Darryl C Zeldin, Timothy J Aitman, Enrico Petretto, Mayte Blay, Jacques Behmoaras
OBJECTIVE: When molecular drivers of healthy adipogenesis are perturbed, this can cause hepatic steatosis. The role of arachidonic acid (AA) and its downstream enzymatic cascades, such as cyclooxygenase, in adipogenesis is well established. The exact contribution of the P450 epoxygenase pathway, however, remains to be established. Enzymes belonging to this pathway are mainly encoded by the CYP2J locus which shows extensive allelic expansion in mice. Here we aimed to establish the role of endogenous epoxygenase during adipogenesis under homeostatic and metabolic stress conditions...
March 9, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29653099/herbacetin-a-flaxseed-flavonoid-ameliorates-high-percent-dietary-fat-induced-insulin-resistance-and-lipid-accumulation-through-the-regulation-of-hepatic-lipid-metabolizing-and-lipid-regulating-enzymes
#15
Chinnadurai Veeramani, Mohammed A Alsaif, Khalid S Al-Numair
Healthy plants and their constituents have been considered as a safe remedy for the treatment of obesity and obesity associated diseases. Herbacetin is a dietary flavonoid that has been explored for many pharmacological activities; but, the anti-hyperglycaemic and anti-hyperlipidemic properties of herbacetin have not yet been explored. The present study was performed to evaluate the ameliorative effect of herbacetin on high-fat diet-induced hyperglycaemia and hyperlipidemia in 57BL/6 J mice. Obesity associated insulin resistance was induced by continuously feeding the mice with high-fat diet for 10 weeks...
April 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29650791/impairments-in-adipose-tissue-microcirculation-in-type-2-diabetes-mellitus-assessed-by-real-time-contrast-enhanced-ultrasound
#16
Donghua Hu, Devika Remash, Ryan D Russell, Timothy Greenaway, Stephen Rattigan, Kathryn A Squibb, Graeme Jones, Dino Premilovac, Stephen M Richards, Michelle A Keske
BACKGROUND: In obesity and type 2 diabetes mellitus (T2D), adipose tissue expansion (because of larger adipocytes) results in reduced microvascular density which is thought to lead to adipocyte hypoxia, inflammation, and reduced nutrient delivery to the adipocyte. Adipose tissue microvascular responses in humans with T2D have not been extensively characterized. Furthermore, it has not been determined whether impaired microvascular responses in human adipose tissue are most closely associated with adiposity, inflammation, or altered metabolism...
April 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29649378/poor-sleep-quality-is-associated-with-insulin-resistance-in-postmenopausal-women-with-and-without-metabolic-syndrome
#17
Christopher E Kline, Martica H Hall, Daniel J Buysse, Conrad P Earnest, Timothy S Church
BACKGROUND: Poor sleep quality has previously been shown to be related to insulin resistance in apparently healthy adults. However, it is unclear whether an association between sleep quality and insulin resistance exists among adults with metabolic syndrome (MetS). METHODS: Participants included 347 overweight/obese postmenopausal women without type 2 diabetes (age: 57.5 ± 6.5 years; body mass index [BMI]: 31.7 ± 3.7 kg/m2 ; 54% with MetS). Sleep quality was assessed with the six-item Medical Outcomes Study Sleep Scale; values were categorized into quartiles...
March 20, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29643322/metabolically-healthy-obesity-and-risk-of-leukoaraiosis-a-population-based-cross-sectional-study
#18
Takuro Okamura, Yoshitaka Hashimoto, Masahide Hamaguchi, Akihiro Ohbora, Takao Kojima, Michiaki Fukui
Metabolically healthy obese (MHO) individual is known to be defended from the metabolic complications of obesity. Leukoaraiosis, which is commonly detected on brain magnetic resonance imaging (MRI), is now recognized as a risk of stroke, dementia and death. However, the association between MHO and the prevalence of leukoaraiosis is unclear. In this cross-sectional study of 796 participants who received a medical examination program, we investigated the association between MHO and the prevalence of leukoaraiosis...
April 10, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29629481/trace-elements-in-saliva-as-markers-of-type-2-diabetes-mellitus
#19
Luis Marín Martínez, Diana Molino Pagán, Pía López Jornet
To analyze Mg, Ca, and Zn levels in saliva, comparing patients with type 2 diabetes mellitus and a control group of healthy subjects. This transversal, observational, clinical study included a total sample of 147 patients, 74 with type 2 diabetes mellitus and a control group of 73 healthy subjects. Socio-demographic, anthropometric, diabetological, and metabolic variables were registered. Trace elements in non-stimulated basal saliva were measured using inductively coupled plasma mass spectrometry (ICP-MS): Mg, Ca, and Zn...
April 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29628481/the-association-between-metabolically-healthy-obesity-and-the-risk-of-proteinuria-the-kansai-healthcare-study
#20
Shinichiro Uehara, Kyoko Kogawa Sato, Hideo Koh, Mikiko Shibata, Shigeki Kinuhata, Akiko Yamada, Keiko Oue, Hiroshi Kambe, Michio Morimoto, Tomoshige Hayashi
BACKGROUND: Metabolically healthy obesity seems to be a unique phenotype for the risk of cardiometabolic diseases. However, it is not known whether this phenotype is associated with the risk of proteinuria. METHODS: Study subjects were 9,185 non-diabetic Japanese male workers aged 40-55 years who had no proteinuria, an estimated glomerular filtration rate ≥60 mL/min/1.73 m2 , no history of cancer, and no use of antihypertensive or lipid-lowering medications at baseline...
April 7, 2018: Journal of Epidemiology
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