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Metabolically healthy obese

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https://www.readbyqxmd.com/read/29030686/blood-mercury-concentration-in-relation-to-metabolic-and-weight-phenotypes-using-the-knhanes-2011-2013-data
#1
Kayoung Lee
PURPOSE: We assessed the association of blood mercury concentration with metabolic and weight phenotypes. METHODS: Blood mercury concentration, metabolic syndrome components, and body mass index (BMI) were measured in 6006 Korean adults (2963 men, 3043 women, mean age 44.7 ± 14.7 years), using the 2011-2013 Korean National Health and Nutrition Examination Survey data. Metabolic and weight phenotypes were classified based on BMI and metabolic syndrome (MetS) presence as metabolically healthy and normal weight (MHNW), metabolically unhealthy and normal weight (MUNW), metabolically healthy and obese (MHO), and metabolically unhealthy and obese (MUO)...
October 13, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29029011/obesity-and-prognosis-time-to-forget-about-metabolically-healthy-obesity
#2
Xavier Garcia-Moll
No abstract text is available yet for this article.
September 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29028831/short-term-vitamin-e-treatment-impairs-reactive-oxygen-species-signaling-required-for-adipose-tissue-expansion-resulting-in-fatty-liver-and-insulin-resistance-in-obese-mice
#3
Martin Alcala, Maria Calderon-Dominguez, Dolors Serra, Laura Herrero, Maria P Ramos, Marta Viana
OBJECTIVES: The use of antioxidant therapy in the treatment of oxidative stress-related diseases such as cardiovascular disease, diabetes or obesity remains controversial. Our aim is to demonstrate that antioxidant supplementation may promote negative effects if used before the establishment of oxidative stress due to a reduced ROS generation under physiological levels, in a mice model of obesity. METHODS: C57BL/6J mice were fed with a high-fat diet for 14 weeks, with (OE group) or without (O group) vitamin E supplementation...
2017: PloS One
https://www.readbyqxmd.com/read/29026443/neutrophil-killing-of-staphylococcus-aureus-in-diabetes-obesity-and-metabolic-syndrome-a-prospective-cellular-surveillance-study
#4
Ingrid Lea Scully, Lisa Kristin McNeil, Sudam Pathirana, Christine Lee Singer, Yongdong Liu, Stanley Mullen, Douglas Girgenti, Alejandra Gurtman, Michael W Pride, Kathrin Ute Jansen, Paul L Huang, Annaliesa S Anderson
BACKGROUND: Obesity, metabolic syndrome (MetS), and diabetes are frequent in surgical populations and can enhance susceptibility to postoperative surgical site infections. Reduced neutrophil function has been linked with diabetes and risk of Staphylococcus aureus infection. Therefore, neutrophil function in diabetic and obese subjects (± MetS) was assessed in this prospective serological and cellular surveillance study to determine whether vaccines administered to protect against infections after surgery could be effective in these populations...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29021511/overcoming-sleep-disordered-breathing-and-ensuring-sufficient-good-sleep-time-for-a-healthy-life-expectancy
#5
Kazuo Chin
Recent advances in basic and clinical medicine have resulted in major improvements in human health. Currently sleep has been considered an essential factor in maintaining and promoting a healthy life expectancy. Sleep disorders include more than 60 diseases. Sleep disordered breathings (SDB) have 17 disorders, including sleep apnea. SDB usually induces hypoxemia and hypercapnia, which would have significant effects on cells, organs, and the whole body. We have investigated SDB for nearly 35 years. We found that SDB has significant associations with humoral factors, including coagulation systems, the body's protective factors against diseases, and metabolic and organ diseases...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/29020414/separate-and-combined-associations-of-obesity-and-metabolic-health-with-coronary-heart-disease-a-pan-european-case-cohort-analysis
#6
Camille Lassale, Ioanna Tzoulaki, Karel G M Moons, Michael Sweeting, Jolanda Boer, Laura Johnson, José María Huerta, Claudia Agnoli, Heinz Freisling, Elisabete Weiderpass, Patrik Wennberg, Daphne L van der A, Larraitz Arriola, Vassiliki Benetou, Heiner Boeing, Fabrice Bonnet, Sandra M Colorado-Yohar, Gunnar Engström, Anne K Eriksen, Pietro Ferrari, Sara Grioni, Matthias Johansson, Rudolf Kaaks, Michail Katsoulis, Verena Katzke, Timothy J Key, Giuseppe Matullo, Olle Melander, Elena Molina-Portillo, Concepción Moreno-Iribas, Margareta Norberg, Kim Overvad, Salvatore Panico, J Ramón Quirós, Calogero Saieva, Guri Skeie, Annika Steffen, Magdalena Stepien, Anne Tjønneland, Antonia Trichopoulou, Rosario Tumino, Yvonne T van der Schouw, W M Monique Verschuren, Claudia Langenberg, Emanuele Di Angelantonio, Elio Riboli, Nicholas J Wareham, John Danesh, Adam S Butterworth
Aims: The hypothesis of 'metabolically healthy obesity' implies that, in the absence of metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk. We tested this hypothesis in a large pan-European prospective study. Methods and results: We conducted a case-cohort analysis in the 520 000-person European Prospective Investigation into Cancer and Nutrition study ('EPIC-CVD'). During a median follow-up of 12.2 years, we recorded 7637 incident coronary heart disease (CHD) cases...
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018189/the-gut-microbiome-in-atherosclerotic-cardiovascular-disease
#7
Zhuye Jie, Huihua Xia, Shi-Long Zhong, Qiang Feng, Shenghui Li, Suisha Liang, Huanzi Zhong, Zhipeng Liu, Yuan Gao, Hui Zhao, Dongya Zhang, Zheng Su, Zhiwei Fang, Zhou Lan, Junhua Li, Liang Xiao, Jun Li, Ruijun Li, Xiaoping Li, Fei Li, Huahui Ren, Yan Huang, Yangqing Peng, Guanglei Li, Bo Wen, Bo Dong, Ji-Yan Chen, Qing-Shan Geng, Zhi-Wei Zhang, Huanming Yang, Jian Wang, Jun Wang, Xuan Zhang, Lise Madsen, Susanne Brix, Guang Ning, Xun Xu, Xin Liu, Yong Hou, Huijue Jia, Kunlun He, Karsten Kristiansen
The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29017004/eating-frequency-predicts-changes-in-regional-body-fat-distribution-in-healthy-adults
#8
G Georgiopoulos, K Karatzi, M Yannakoulia, E Georgousopoulou, E Efthimiou, A Mareti, I Bakogianni, A Mitrakou, C Papamichael, K Stamatelopoulos
Background: Eating frequency (EF) has been associated with generalized obesity. Aim: We aimed to prospectively investigate potential associations of frequency of eating episodes with regional fat layers. Design: EF was evaluated at baseline in 115 subjects free of clinically overt cardiovascular disease (54 ± 9.1 years, 70 women) in a prospective, observational study. Methods: Metabolic parameters known to be associated with dietary factors and anthropometric markers including ultrasound assessment of subcutaneous (Smin) and pre-peritoneal (Pmax) fat and their ratio Smin/Pmax (AFI) were evaluated at baseline and at follow-up, 5 years later...
June 21, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28991084/association-among-obesity-metabolic-health-and-the-risk-for-colorectal-cancer-in-the-general-population-in-korea-using-the-national-health-insurance-service-national-sample-cohort
#9
Cheol Min Shin, Kyungdo Han, Dong Ho Lee, Yoon Jin Choi, Nayoung Kim, Young Soo Park, Hyuk Yoon
BACKGROUND: In Korea, the incidence of colorectal cancer has increased and obesity is on a rising trend because of a Westernized lifestyle in men. OBJECTIVE: The purpose of this study was to evaluate the relationship between metabolic health status, as well as BMI, and the incidence of colorectal cancer. DESIGN: This was a prospective cohort study. SETTINGS: The study was conducted with the National Health Insurance Service-National Sample Cohort...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28990591/incidence-of-components-of-metabolic-syndrome-in-the-metabolically-healthy-obese-over-9-years-follow-up-the-atherosclerosis-risk-in-communities-study
#10
P T Bradshaw, K R Reynolds, L E Wagenknecht, C E Ndumele, J Stevens
BACKGROUND: Some obese adults are not afflicted by the metabolic abnormalities often associated with obesity [the 'metabolically healthy obese' (MHO)], however, they may be at increased risk of developing cardiometabolic abnormalities in the future. Little is known about the relative incidence of individual components of metabolic syndrome (MetSyn). METHODS: We used data from a multi-center, community-based cohort aged 45-64 years at recruitment [the Atherosclerosis Risk in Communities (ARIC) study] to examine the first appearance of any MetSyn component, excluding waist circumference...
October 9, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28989878/prevalence-of-metabolic-syndrome-markers-among-women-at-1-year-postpartum-as-per-prepregnancy-body-mass-index-status-a-longitudinal-study
#11
Neha A Kajale, Vaman Khadilkar, Shashi A Chiplonkar, Raja Padidela, Anuradha V Khadilkar
INTRODUCTION: Maternal body composition (BC) changes during lactation. Increased prepregnancy obesity is associated with poor obstetric outcomes. The aim was to study changes in maternal BC postpartum (PP) to 1-year PP with reference to their prepregnancy body mass index (BMI) status. METHODS: The study design was a 1-year follow-up study. Sixty-five apparently healthy primiparous women (28.6 ± 3.4 years delivered full-term infants) were randomly selected from December 2010 to June 2013 and postclassified on the basis of their prepregnancy BMI status...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28987777/palestinian-arab-ethnicity-is-associated-with-an-adverse-metabolic-phenotype
#12
Ram Weiss, Hisham Nassar, Ronit Sinnreich, Wiessam Abu Ahmad, James Otvos, Jeremy D Kark
Urban-dwelling Palestinians have been shown to have higher cardiovascular morbidity and mortality and prevalence of diabetes than urban Israelis. Inflammation is implicated in the etiology of these conditions. We hypothesized that increased inflammatory activation, manifested as increased GlycA, a novel biomarker of global inflammation, would be evident in Palestinians. We compared GlycA concentrations between Palestinians and Israelis and assessed the associations of GlycA with anthropometric, health behavioral and clinical variables in a sample of 1674 Palestinians and Israelis aged 25-74, residing in Jerusalem...
October 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28987250/differences-between-metabolically-healthy-vs-unhealthy-obese-children-and-adolescents
#13
Aditi Khokhar, Vivian Chin, Sheila Perez-Colon, Tanni Farook, Shipra Bansal, Elna Kochummen, Vatcharapan Umpaichitra
Obesity is on the rise worldwide. An obesity subtype, metabolically healthy obese (MHO), is resilient to unfavorable metabolic and cardiovascular effects. Factors predicting MHO phenotype are not well characterized. We aimed to identify MHO and metabolically unhealthy obese (MUO) children and adolescents with respect to metabolic factors, and to find predictors of MHO subtype. A retrospective chart review was done on children, ages 4-19 years, 99% African-American/Caribbean, with BMI ≥95th %tile. MUO was defined as meeting ≥1 of the following: fasting glucose ≥100 mg/dl, HbA1c >5...
2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28984844/maternal-obesity-heritably-perturbs-offspring-metabolism-for-three-generations-without-serial-programming
#14
S A Eaton, A J Aiken, P E Young, J W K Ho, J E Cropley, C M Suter
Maternal obesity can program offspring metabolism across multiple generations. It is not known whether multigenerational effects reflect true inheritance of the induced phenotype, or are due to serial propagation of the phenotype through repeated exposure to a compromised gestational milieu. Here we sought to distinguish these possibilities, using the A(vy) mouse model of maternal obesity. In this model, F1 sons of obese dams display a predisposition to hepatic insulin resistance which remains latent unless the offspring are challenged with a Western diet...
October 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28984255/risk-factors-for-cardiovascular-disease-in-obese-children
#15
T Chandrasekhar, M M Suchitra, M Pallavi, P V L N Srinivasa Rao, Alok Sachan
OBJECTIVE: To study the prevalence of cardiovascular risk factors in pediatric obesity. METHODS: 50 obese children (age 5-17y) and 50 apparently healthy non-obese children (body mass index of over 95th percentile and between 5th to 95th percentiles, respectively) using Centre for Disease Control growth charts were included. Fasting blood sugar, lipid profile, insulin, homeostasis model assessment of insulin resistance, uric acid, fibrinogen, lipoprotein (a), homocysteine, malondialdehyde, ferric reducing ability of plasma and nitric oxide were measured...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28983981/neurocognitive-performances-of-visuospatial-attention-and-the-correlations-with-metabolic-and-inflammatory-biomarkers-in-adults-with-obesity
#16
Chia-Liang Tsai, Tsang-Hai Huang, Meng-Che Tsai
The purposes of the present study were to explore the neurophysiological mechanism of visuospatial attention deficits in the adults with obesity, and to examine the relationships between neurocognitive (neuropsychological and neurophysiological) performances and the biochemical markers. Thirty adults with obesity and 30 healthy-weight controls, categorized by body mass index and %fat as measured with dual-energy X-ray absorptiometry, completed a fasting blood draw and performed a visuospatial attention paradigm with concomitant electrophysiological recording...
October 5, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28982656/changing-the-obesogenic-environment-to-improve-cardiometabolic-health-in-residential-patients-with-a-severe-mental-illness-cluster-randomised-controlled-trial
#17
Anne Looijmans, Annemarie P M Stiekema, Richard Bruggeman, Lisette van der Meer, Ronald P Stolk, Robert A Schoevers, Frederike Jörg, Eva Corpeleijn
BackgroundFor patients with severe mental illness (SMI) in residential facilities, adopting a healthy lifestyle is hampered by the obesity promoting (obesogenic) environment.AimsTo determine the effectiveness of a 12-month lifestyle intervention addressing the obesogenic environment with respect to diet and physical activity to improve waist circumference and cardiometabolic risk factors v. care as usual (Dutch Trial Registry: NTR2720).MethodIn a multisite cluster randomised controlled pragmatic trial, 29 care teams were randomised into 15 intervention (365 patients) and 14 control teams (371 patients)...
October 5, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28982486/weight-gain-in-women-at-midlife-a-concise-review-of-the-pathophysiology-and-strategies-for-management
#18
REVIEW
Ekta Kapoor, Maria L Collazo-Clavell, Stephanie S Faubion
Weight gain accompanied by an increased tendency for central fat distribution is common among women in midlife. These changes are a result of aging, decreasing estrogen levels after menopause, and other unique influences in menopausal women that interfere with the adoption of healthy lifestyle measures. Central obesity, in particular, results in several adverse metabolic consequences, including dysglycemia, dyslipidemia, hypertension, and cardiovascular disease. Given that cardiovascular disease is the leading cause of death in postmenopausal women, the importance of weight management in midlife cannot be overemphasized...
October 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28981243/-treatments-of-non-alcoholic-steatohepatitis
#19
T Gustot
Non-alcoholic fatty liver diseases are highly prevalent in Western countries and associated with insulin resitance and metabolic syndrome. Non-alcoholic steatohepatitis (NASH) is characterized by lobular inflammation and hepatocellular ballooning, and may be associated with liver fibrosis leading to cirrhosis and its complications as hepatocarcinoma. The presence of obesity, type 2 diabetes mellitus or increased liver enzymes in patients with metabolic syndrome should prompt non-invasive screening (liver ultrasound, serum markers and/or transient elastography) to predict steatosis, NASH and fibrosis...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28978976/subcutaneous-adipose-tissue-gene-expression-and-dna-methylation-respond-to-both-short-and-long-term-weight-loss
#20
S Bollepalli, S Kaye, S Heinonen, J Kaprio, A Rissanen, K A Virtanen, K H Pietiläinen, M Ollikainen
BACKGROUND: Few studies have examined both gene expression and DNA methylation profiles in subcutaneous adipose tissue (SAT) during long-term weight loss. Thus molecular mechanisms in weight loss and regain remain elusive. PARTICIPANTS/METHODS: We performed a one-year weight loss intervention on 19 healthy obese participants (mean BMI 34.6 kg/m(2)) and studied longitudinal gene expression (Affymetrix Human Genome U133 Plus 2.0) and DNA methylation (Infinium HumanMethylation450 BeadChip) in SAT at 0, 5 and 12 months...
October 5, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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