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Pancreas embryology

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https://www.readbyqxmd.com/read/29580319/liver-and-pancreas-do-similar-embryonic-development-and-tissue-organization-lead-to-similar-mechanisms-of-tumorigenesis
#1
Elsa Ghurburrun, Ivan Borbath, Frédéric P Lemaigre, Patrick Jacquemin
Liver and pancreas are closely associated organs which share a common embryological origin. They display amphicrine properties and have similar exocrine organization with parenchymal cells, namely hepatocytes and acinar cells, secreting bile and pancreatic juice into the duodenum via a converging network of bile ducts and pancreatic ducts. Here we compare and highlight the similarities of molecular mechanisms leading to liver and pancreatic cancer development. We suggest that unraveling tumor development in an organ may provide insight into our understanding of carcinogenesis in the other organ...
March 26, 2018: Gene Expression
https://www.readbyqxmd.com/read/29560005/pancreaticoduodenectomy-for-an-ampullary-region-carcinoma-occurred-in-annular-pancreas-coexistent-with-replaced-common-hepatic-artery
#2
Ryuji Komine, Atsushi Shimizu, Kazuhiko Mori, Keisuke Minamimura, Toru Hirata, Takashi Kobayashi, Nobuo Toda, Masaya Mori
Introduction: Annular pancreas is a rare congenital abnormality characterized by a ring of pancreatic tissue surrounding the descending portion of the duodenum. Annular pancreas coexisting with replaced common hepatic artery which is also a rare anatomical variation has not been reported previously. Case Presentation: A 53-year-old man visited our hospital complaining of epigastric pain. Based on radiological examinations, he was diagnosed as having pancreatitis, annular pancreas, and hepatomesenteric trunk...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29245220/case-report-of-intestinal-non-rotation-heterotaxy-and-polysplenia-in-a-patient-with-pancreatic-cancer
#3
Spyridon Pagkratis, Sara Kryeziu, Miranda Lin, Samah Hoque, Juan Carlos Bucobo, Jonathan M Buscaglia, Georgios V Georgakis, Aaron R Sasson, Joseph Kim
RATIONALE: Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly complex. This case report demonstrates successful pancreatic cancer resection despite the patient's complicated anatomy. PATIENT CONCERNS: An 82-year-old female presented to our institution with complaints of mild right upper quadrant pain radiating to the mid-epigastric region...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29029025/insulin-deficient-mouse-%C3%AE-cells-do-not-fully-maturebut-can-be-remedied-through-insulin-replacementby-islet-transplantation
#4
COMPARATIVE STUDY
Adam Ramzy, Majid Mojibian, Timothy J Kieffer
Insulin receptor (IR) insufficiency in β-cells leads to impaired insulin secretion and reduced β-cell hyperplasia in response to hyperglycemia. Selective IR deficiency in β-cells in later embryological development may lead to compensatory β-cell hyperplasia. Although these findings suggest insulin signaling on the β-cell is important for β-cell function, they are confounded by loss of signaling by the insulinlike growth factors through the IR. To determine whether insulin itself is necessary for β-cell development and maturation, we performed a characterization of pancreatic islets in mice with deletions of both nonallelic insulin genes (Ins1-/-Ins2-/-)...
January 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29028511/a-pictorial-review-of-diagnostic-pitfalls-of-developmental-anomalies-and-variants-in-pancreatic-imaging
#5
REVIEW
Jong Eun Lee, Sang Soo Shin, Shin Jung Kim, Suk Hee Heo, Hyo Soon Lim, Jin Woong Kim, Yong Yeon Jeong
Developmental anomalies and anatomic variants of the pancreas vary widely, and most of them are encountered incidentally during radiologic evaluation. However, some of these anomalies and variants are potentially pathologic and may cause various clinical presentations in childhood or adulthood. The early identification of these entities in various imaging modalities including ultrasound, computed tomography (CT), and magnetic resonance (MR) imaging would be valuable in making correct diagnoses and, in turn, preventing unnecessary additional procedures...
March 2018: Clinical Imaging
https://www.readbyqxmd.com/read/28932042/small-cell-neuroendocrine-carcinoma-of-the-paranasal-sinus-with-intraoral-involvement-report-of-a-rare-case-and-review-of-the-literature
#6
Anita Spadigam, Anita Dhupar, Shaheen Syed, Shruti U Nagvekar
The diffuse neuroendocrine system continues to be an enigmatic topic of study in pathology due to its controversial embryologic origins, biology and a variety of tumors engendered. Originally thought to be localized to the classic neuroendocrine organs (pituitary, thyroid, pancreas and adrenal medulla), the neuroendocrine cells are now known to be distributed in every organ system of the body. A number of human diseases have been linked to aberrations in the functioning of the neuroendocrine cells. Neoplasms of the neuroendocrine system can thus occur in myriad primary sites and range in behavior from benign to lethal...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28871557/anatomy-of-the-transverse-mesocolon-based-on-embryology-for-laparoscopic-complete-mesocolic-excision-of-right-sided-colon-cancer
#7
Takeru Matsuda, Yasuo Sumi, Kimihiro Yamashita, Hiroshi Hasegawa, Masashi Yamamoto, Yoshiko Matsuda, Shingo Kanaji, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
BACKGROUND: To treat colon cancer via complete mesocolic excision (CME) with central vascular ligation (CVL), dissection along the embryologic fusion planes is required. However, this surgery is difficult, especially for right-sided colon cancer, because the anatomy and embryology of the transverse mesocolon are not familiar to gastrointestinal surgeons. METHODS: In this video article, the anatomic details of the transverse mesocolon based on embryology are illustrated with a focus on the venous anatomy...
November 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28655083/-anatomic-study-and-clinical-practice-of-mesopancreas-and-total-mesopancreatic-excision
#8
J Y Xu, Y R Chen, C Liu, L Tian, J W Wang, D Cui, Y Wang, W G Zhang, Y M Yang
Objective: To explore the anatomical characteristics of the mesopancreas, to define the range of the total mesopancreas excision and to evaluate the feasibility, safety and effectiveness in the treatment of pancreatic cancer. Methods: A regional anatomical and pathological study was performed on 14 cadavers with large slices and paraffin sections. The clinical and pathological data of 58 consecutive patients underwent total mesopancreas excision for pancreatic head carcinoma from January 2013 to December 2015 were prospectively collected and analysed...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28432408/a-rare-anastomosis-between-the-common-hepatic-artery-and-the-superior-mesenteric-artery-a-case-report
#9
Łukasz Olewnik, Grzegorz Wysiadecki, Michał Polguj, Mirosław Topol
For decades, anastomoses between unpaired branches of the abdominal aorta have attracted the attention of anatomists, surgeons and radiologists, due to their significance in many clinical procedures. This report presents a rare anastomosis between the common hepatic artery and the superior mesenteric artery, which gave off three branches to the jejunum. The diameter of the anastomosis measured at the point of its branching off the common hepatic artery and at the level of union with the superior mesenteric artery was 4...
October 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28364316/a-case-of-annular-pancreas-with-wirsung-s-duct-encircling-the-duodenum-embryological-hypothesis-based-on-cholangiopancreatographic-and-immunohistochemical-findings
#10
Manami Fukai, Terumi Kamisawa, Shin-Ichirou Horiguchi, Tsunekazu Hishima, Sawako Kuruma, Kazuro Chiba, Satomi Koizumi, Taku Tabata, Sayaka Nagao, Masataka Kikuyama, Goro Honda, Masanao Kurata
We present a resected case of annular pancreas in which Wirsung's duct encircled the duodenum and continued directly to the main pancreatic duct in the body and tail. Furthermore, Wirsung's duct coursed along the right side of the lower bile duct near the major duodenal papilla. Histologically, the islets of Langerhans in the annular pancreas were irregular in shape and were characterized by a striking abundance of pancreatic polypeptide (PP)-positive cells. The PP-rich area that encircled the duodenum was fused with the PP-poor area in the head of the pancreas...
June 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28205123/isolated-pancreatic-uncinate-duct-ipmn
#11
Ajay V Maker, Vijay K Maker
The ventral pancreas originally forms as an evagination of the common bile duct at 32 days gestation and its duct, the uncinate duct, eventually rotates with the ventral anlage to join the dorsal pancreas and fuse with the main pancreatic duct. Thus, though often considered a "branch" duct of the pancreas, embryologically, the uncinate duct is the "main" pancreatic duct of the ventral pancreas. This concept is not fully addressed in the current definitions of intraductal papillary mucinous neoplasms of the pancreas (IPMN) where international consensus guidelines consider the main-duct IPMN as high risk for malignancy and most small branch-duct IPMN as low risk for malignancy...
April 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28182631/zebrafish-atoh8-mutants-do-not-recapitulate-morpholino-phenotypes
#12
Elsie S Place, James C Smith
Atoh8 is a bHLH transcription factor expressed in pancreas, skeletal muscle, the nervous system, and cardiovascular tissues during embryological development. Although it has been implicated in the regulation of pancreatic and endothelial cell differentiation, the phenotypic consequences of Atoh8 loss are uncertain. Conclusions from knockout studies in the mouse differ widely depending on the targeting strategy used, while atoh8 knockdown by interfering morpholino oligonucleotides (morpholinos) in zebrafish has led to a range of developmental defects...
2017: PloS One
https://www.readbyqxmd.com/read/28135676/horizontal-traumatic-laceration-of-the-pancreas-head-a-rare-case-report
#13
Atsushi Nanashima, Naoya Imamura, Yuki Tsuchimochi, Takeomi Hamada, Kouichi Yano, Masahide Hiyoshi, Yoshiro Fujii, Fumiaki Kawano, MitsuruTamura
INTRODUCTION: This case report is intended to inform acute care surgeons about treating rare horizontal laceration of the pancreas head caused by blunt trauma. CASE PRESENTATION: A 57-year-old woman who sustained blunt abdominal trauma during a car crash was transported to the emergency center of our hospital with unstable vital signs due to hemorrhagic shock. Computed tomography showed transection of the pancreas head and massive intra-abdominal hemorrhage. She was referred for emergency surgery because of a transient response...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27995452/an-optimal-approach-for-laparoscopic-d3-lymphadenectomy-plus-complete-mesocolic-excision-d3-cme-for-right-sided-colon-cancer
#14
Daxing Xie, Chaoran Yu, Chun Gao, Hasan Osaiweran, Junbo Hu, Jianping Gong
BACKGROUND: It is common knowledge that high ligation of blood vessels at the D3 level and complete mesocolic excision (CME) are two critical points of right hemicolectomy for right colon cancer (RCC). 1-5 To date, a safe strategy for completing these two procedures under laparoscopic surgery has not been extensively described. The authors provide a video to demonstrate laparoscopic right hemicolectomy (D3 + CME) with an optimal mesentery-defined approach. By identifying three "tri-junctions," this approach facilitates dissection of the entire mesocolon along the embryologic planes as far centrally as possible and enables the high tie of feeding vessels at bifurcation...
May 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27738535/pancreatic-neuroendocrine-tumor-in-the-setting-of-dorsal-agenesis-of-the-pancreas
#15
Samih Nassif, Cecilia Ponchiardi, Teviah Sachs
Dorsal agenesis of the pancreas (DAP) is an uncommon embryological abnormality where there is absence of the distal pancreas. DAP is mostly asymptomatic, but common presenting symptoms include diabetes mellitus, abdominal pain, pancreatitis, enlarged pancreatic head, and, in a few cases, polysplenia. MRCP and ERCP are the gold standard imaging techniques to demonstrate the absence of the dorsal pancreatic duct. The literature on the association of pancreatic neoplasia and DAP is limited. We present the case of a pancreatic neuroendocrine tumor in a patient with dorsal agenesis of the pancreas, with a review of the related literature...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27504274/unusual-variation-in-the-branching-pattern-of-the-celiac-trunk-and-its-embryological-and-clinical-perspective
#16
Shilpi Agarwal, Babita Pangtey, Neelam Vasudeva
Knowledge of variations in the branching pattern of Celiac Trunk (CT) is important for surgeries of stomach, duodenum, pancreas and hepatobiliary region, for abdominal aortic aneurysm, for liver transplant and chaemoembolization of hepatic tumours. An unusual variation in the branching pattern of CT was observed in 50-year-old male cadaver of Indian origin. CT divided into six branches out of which right & left inferior phrenic arteries originated as first two branches and left gastric artery as the third branch...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26943696/ciliated-foregut-cyst-in-the-triangle-of-calot-the-first-report
#17
Osama S Al Beteddini, Nasir K Amra, Emad Sherkawi
Ciliated foregut cysts are rare anomalies arising from remnants of aberrant embryological development. Around 100 reports on the presence of these congenital masses in the tracheobronchial tree, mediastinum, liver, pancreas and, rarely, the gallbladder have been described. In this article, the case of a 33-year-old woman, who was operated for a laparoscopic cholecystectomy, is presented. During the dissection of the triangle of Calot, a cystic mass, attached to the common hepatic duct, was discovered incidentally...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/26929735/the-role-of-gastrin-and-cck-receptors-in-pancreatic-cancer-and-other-malignancies
#18
REVIEW
Jill P Smith, Lionel K Fonkoua, Terry W Moody
The gastrointestinal (GI) peptide gastrin is an important regulator of the release of gastric acid from the stomach parietal cells and it also plays an important role in growth of the gastrointestinal tract. It has become apparent that gastrin and its related peptide cholecystokinin (CCK) are also significantly involved with growth of GI cancers as well as other malignancies through activation of the cholecystokinin-B (CCK-B) receptor. Of interest, gastrin is expressed in the embryologic pancreas but not in the adult pancreas; however, gastrin becomes re-expressed in pancreatic cancer where it stimulates growth of this malignancy by an autocrine mechanism...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/26897927/anatomical-resection-of-the-bile-duct-a-hidden-door-to-the-bile-duct
#19
Soichi Narumoto, Ken Hayashi, Hitoshi Seki, Yasuhiro Munakata
BACKGROUND/AIMS: Pancreas-preserving resection of the bile duct has been attempted as an organ preserving procedures for the treatment of low-grade malignant neoplasms of the bile duct. The fact that the lower bile duct penetrates pancreas head to join the duodenum, makes those attempts one of the challenging procedures in biliary tract surgery. Here we present a novel and unique surgical technique for anatomically resecting lower bile duct, focusing on the anatomy of the pancreas head...
May 2015: Hepato-gastroenterology
https://www.readbyqxmd.com/read/26890682/a-rare-gallbladder-ciliated-foregut-cyst-in-chronic-cholecystitis
#20
Mee-Jin Lee, James Salinas, Winny Varikatthas, Ghiyath Alsnih
INTRODUCTION: Ciliated foregut cysts (CFC) are rare anomalies due to aberrant embryological development. It is thought to arise from a remnant of the embryologic foregut. The solitary cysts are characterised by ciliated pseudostratified columnar epithelium. They are usually located above the diaphragm but they can also arise in relation to the liver, gallbladder and pancreas. PRESENTATION OF CASE: We present the first ciliated foregut cyst of the gallbladder case reported in Australia, and the ninth known case to be reported worldwide...
2016: International Journal of Surgery Case Reports
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