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https://www.readbyqxmd.com/read/28736725/intraoperative-radiation-therapy-a-promising-treatment-modality-in-head-and-neck-cancer
#1
REVIEW
Lara Hilal, Karine A Al Feghali, Paul Ramia, Ibrahim Abu Gheida, Jean-Pierre Obeid, Wassim Jalbout, Bassem Youssef, Fady Geara, Youssef H Zeidan
Every year, almost 62,000 are diagnosed with a head and neck cancer (HNC) and 13,000 will succumb to their disease. In the primary setting, intraoperative radiation therapy (IORT) can be used as a boost in select patients in order to optimize local control. Addition of external beam radiation to limited volumes results in improved disease control over surgery and IORT alone. In the recurrent setting, IORT can improve outcomes from salvage surgery especially in patients previously treated with external beam radiation...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28731191/carboxy-terminus-hsc70-interacting-protein-exerts-a-tumor-inhibition-function-in-head-and-neck-cancer
#2
Meng Xiao, Ming Yan, Jianjun Zhang, Qin Xu, Wantao Chen
Several independent studies have reported the roles of the E3 ubiquitin ligase, carboxy-terminus Hsc70 interacting protein (CHIP) in various types of cancers. However, the biological effects of CHIP vary in regards to different cancers, and the role of CHIP in head and neck cancers (HNCs) remains unknown. In the present study, CHIP overexpression plasmids and CHIP knockdown lentivirus were constructed to affect the expression levels of CHIP protein and biological behaviors in HNC cell lines bilaterally. The biological behaviors regulated by CHIP in HNCs were investigated both in vivo and in vitro with a series of assays and analyses...
July 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28726060/psychosocial-issues-in-patients-with-head-and-neck-cancer-an-updated-review-with-a-focus-on-clinical-interventions
#3
REVIEW
Joshua D Smith, Andrew G Shuman, Michelle B Riba
PURPOSE OF REVIEW: There are frequent and diverse psychosocial issues that afflict patients with head and neck cancer (HNC) across the illness trajectory, prompting a focus on clinical interventions to prevent and mitigate psychosocial distress. We sought to characterize current understanding on the cause, effects, and interplay of various psychosocial factors in HNC and summarize updated, evidence-based interventions. RECENT FINDINGS: The psychosocial experience of patients with HNC is characterized by a disproportionately high incidence of depression, suicide, continued substance dependence/abuse, and distress related to relationship conflict, social isolation, disfigurement, and damage to self-image...
September 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28725868/physico-mechanical-thermal-and-morphological-properties-of-furfuryl-alcohol-2-ethylhexyl-methacrylate-halloysite-nanoclay-wood-polymer-nanocomposites-wpncs
#4
Md Rezaur Rahman, Sinin Hamdan, Josephine Chang Hui Lai, Mohammad Jawaid, Fahmi Asyadi Bin Md Yusof
In this study, the physical, morphological, mechanical and thermal properties of furfuryl alcohol/2-ethylhexyl methacrylate/halloysite nanoclay wood polymer nanocomposites (FA-co-EHMA-HNC WPNCs) were investigated. FA-co-EHMA-HNC WPNCs were prepared via an impregnation method and the properties of the nanocomposites were characterized through the weight percent gain, Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), three-point flexural test, dynamic mechanical thermal analysis (DMTA), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) analysis and moisture absorption test...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28721019/inhibitors-of-the-pd-1-pd-l1-axis-for-the-treatment-of-head-and-neck-cancer-current-status-and-future-perspectives
#5
REVIEW
Xiongwen Ran, Kai Yang
Head and neck cancer (HNC) is a common malignant tumor, but traditional therapeutic methods have unsatisfactory curative effects and many complications occur. Hence, there is an urgent need to develop therapeutic methods that can elicit curative effects as well as low toxic and few side effects. With the development of cancer molecular biology and immunology, targeted therapy for immune checkpoints of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) has shown enormous development prospects for HNC treatment...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28710831/dietary-fiber-intake-and-head-and-neck-cancer-risk-a-pooled-analysis-in-the-international-head-and-neck-cancer-epidemiology-consortium
#6
Daisuke Kawakita, Yuan-Chin Amy Lee, Federica Turati, Maria Parpinel, Adriano Decarli, Diego Serraino, Keitaro Matsuo, Andrew F Olshan, Jose P Zevallos, Deborah M Winn, Kirsten Moysich, Zuo-Feng Zhang, Hal Morgenstern, Fabio Levi, Karl Kelsey, Michael McClean, Cristina Bosetti, Werner Garavello, Stimson Schantz, Guo-Pei Yu, Paolo Boffetta, Shu-Chun Chuang, Mia Hashibe, Monica Ferraroni, Carlo La Vecchia, Valeria Edefonti
The possible role of dietary fiber in the etiology of head and neck cancers (HNCs) is unclear. We used individual-level pooled data from 10 case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders...
July 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28707400/hormone-factors-play-a-favorable-role-in-female-head-and-neck-cancer-risk
#7
Dana Hashim, Samantha Sartori, Carlo La Vecchia, Diego Serraino, Luigino Dal Maso, Eva Negri, Elaine Smith, Fabio Levi, Stefania Boccia, Gabriella Cadoni, Hung N Luu, Yuan-Chin Amy Lee, Mia Hashibe, Paolo Boffetta
Due to lower female incidence, estimates of exogenous and endogenous hormonal factors in head and neck cancers (HNCs, comprising cancers of the oral cavity, oropharynx, hypopharynx, and larynx) among women have been inconsistent and unable to account for key HNC risk factors. We pooled data from 11 studies from Europe, North America, and Japan. Analysis included 1572 HNC female cases and 4343 controls. Pooled odds ratios (ORs) estimates and their 95% confidence intervals (CIs) were calculated using multivariate logistic regression models adjusting for tobacco smoking and alcohol drinking...
July 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28707205/knowledge-and-preferences-of-primary-care-providers-in-delivering-head-and-neck-cancer-survivorship-care
#8
Callie Berkowitz, Deborah H Allen, Jennifer Tenhover, Leah L Zullig, John Ragsdale, Jonathan E Fischer, Kathryn I Pollak, Bridget F Koontz
Long-term care for head and neck cancer (HNC) survivors is complex and requires coordination among multiple providers. Clinical practice guidelines highlight the role of primary care providers (PCPs) in screening for secondary cancer/recurrence, assessment of late/long-term side effects, and referrals for appropriate specialty management of toxicity. However, these responsibilities may be difficult to meet within the scope of primary care practice. We conducted this study to explore preferences, comfort, and knowledge of PCPs in the care of HNC survivors...
July 14, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28702685/durable-usage-of-patient-reported-outcome-measures-in-clinical-practice-to-monitor-health-related-quality-of-life-in-head-and-neck-cancer-patients
#9
S Duman-Lubberding, C F van Uden-Kraan, F Jansen, B I Witte, S E J Eerenstein, S van Weert, R de Bree, C R Leemans, I M Verdonck-de Leeuw
PURPOSE: To investigate the long-term follow-up (5 years) of implementing patient-reported outcome measures (PROMs) in clinical practice to monitor health-related quality of life (HRQOL) in head and neck cancer (HNC) patients. METHODS: A mixed method design was used. The usage rate of OncoQuest (a touch screen computer system to monitor HRQOL) and the subsequent nurse consultation was calculated among HNC patients who visited the outpatient clinic for regular follow-up, as well as differences between ever users and never users (sociodemographic and clinical characteristics)...
July 12, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28697190/-18-f-fdg-pet-ct-and-histology-for-diagnosing-recurrent-remnant-tumors-in-head-and-neck-cancer-patients-treated-with-radiotherapy
#10
Eun Ji Han, Joo Hyun O, Ie Ryung Yoo, Yeon Sil Kim, Min Sik Kim, Jin Hyoung Kang, Woo Hee Choi
OBJECTIVE: The aim of this study was to assess the diagnostic performance of fluorine-18-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) for locoregional recurrent/residual tumor in patients with head and neck cancer (HNC) who underwent previous radiotherapy (RT). SUBJECTS AND METHODS: (18)F-FDG PET/CT images from patients with HNC who previously underwent RT were retrospectively reviewed. Only cases with histological confirmation within 4 weeks of PET/CT imaging were included...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28693802/the-vicious-circle-of-treatment-induced-toxicities-in-locally-advanced-head-and-neck-cancer-and-the-impact-on-treatment-intensity
#11
REVIEW
Bossi Paolo, Cossu Rocca Maria, Corvò Renzo, Depenni Roberta, Guardamagna Vittorio, Marinangeli Franco, Miccichè Francesco, Trippa Fabio
The intensity of the available treatment approaches for locally-advanced head and neck cancer (HNC) is at the upper limit of tolerance of acute toxicities. Several factors including breakthrough cancer pain, mucositis, dysphagia, local and systemic infections, and nutritional problems are related to treatment intensity. Particularly, pain, as symptom directly associated with the disease or combined with other treatment-related factors, has a major impact on quality of life of HNC patients and ultimately can influence the efficacy of treatments in HNC...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28691045/pharyngocutaneous-fistula-as-an-alternative-access-route-for-inserting-a-percutaneous-endoscopic-gastrostomy-tube-in-head-and-neck-cancer-patients
#12
Louise Deluiz Verdolin Di Palma, Gustavo Francisco de Souza E Mello, Cindy Lis Granados, Ricardo Dardengo Glória, Caroline Sauter Dalbem, Rolantre Lopes da Cruz, Ana Carolina Maron Ayres, Renata Sofia Camara Lisboa, Alexandre Dias Pelosi, Maria Aparecida Ferreira, Gilberto Reynaldo Mansur, Simone Guaraldi da Silva, Theresa Christina Damian Ribeiro, Fernando Luiz Dias
BACKGROUND AND STUDY AIMS:  Performing a percutaneous endoscopic gastrostomy (PEG) in head and neck cancer (HNC) patients can be challenging because of the presence of trismus, pharyngeal obstruction by tumor, and pharyngoesophageal strictures or fistula. Pharyngocutaneous fistula (PCF) is a major postoperative concern in patients submitted to total laryngectomy (TL). In the medical literature to date, the cervical fistula has been used as an access to PEG in only four reports. The aim of this study was to evaluate the safety of cervical fistula for insertion of a PEG tube...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28688679/long-term-toxicities-in-10-year-survivors-of-radiation-treatment-for-head-and-neck-cancer
#13
Yanqun Dong, John A Ridge, Tianyu Li, Miriam N Lango, Thomas M Churilla, Jessica R Bauman, Thomas J Galloway
OBJECTIVES: To characterize the recognized but poorly understood long-term toxicities of radiation therapy (RT) for head and neck cancer (HNC). MATERIALS AND METHODS: We retrospectively evaluated patients treated with curative-intent RT for HNC between 1990 and 2005 at a single institution with systematic multidisciplinary follow-up ≥10years. Long-term toxicities of the upper aerodigestive tract were recorded and assigned to two broad categories: pharyngeal-laryngeal and oral cavity toxicity...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28688678/partner-s-survivorship-care-needs-an-analysis-in-head-and-neck-cancer-patients
#14
Meredith Giuliani, Robin Milne, Maurene McQuestion, Lorna Sampson, Lisa W Le, Jennifer Jones, Terry Cheng, John Waldron, Jolie Ringash
PURPOSE: To determine the number, type and predictors of unmet needs for head and neck cancer (HNC) survivors' partner's. METHODS: Partners of HNC patients were invited to complete the Cancer Survivors' Partners Unmet Needs Survey (CaSPUN). Analysis determined number, proportion and factors associated with greater unmet needs using linear regression. Agreement between the unmet needs of patients and their partners was determined. RESULTS: Among the 44 partners participated 29 reported ≥1 unmet need and 4 had a very high number of needs (31-35)...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28688192/assessment-of-human-papillomavirus-awareness-in-association-with-head-and-neck-cancer-at-a-screening-event
#15
Michael H Berger, Erin R Cohen, Alan G Shamrock, Brandon Chan, Michelle Camp, Kaming Lo, Zoukaa B Sargi
OBJECTIVES/HYPOTHESIS: To assess the baseline awareness of human papillomavirus (HPV) infection as a cause of head and neck cancer (HNC) to design improved targeted screening and education efforts. STUDY DESIGN: Retrospective review of collected survey at a cancer screening event. METHODS: This was a screening event at three hospitals and one community center in Miami, Florida. Participants were recruited throughout the Greater Miami area...
July 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28678755/radiation-therapy-and-serum-salivary-amylase-in-head-and-neck-cancer
#16
REVIEW
Francesca De Felice, Mario Tombolini, Angela Musella, Francesco Marampon, Vincenzo Tombolini, Daniela Musio
Radiation therapy (RT) is a valid treatment option for head and neck cancer (HNC). The risk of RT-induced toxicities is significant, especially due to extended treatment fields. The raise in amylase activity is strictly dependent on the volume of salivary glands included in the irradiated target volume and it is firmly related to the dose. The aim of this review is to report the effects on salivary amylase activity after radiation exposure of salivary glands, in patients with HNC.
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28675770/oral-complications-at-six-months-after-radiation-therapy-for-head-and-neck-cancer
#17
Rajesh V Lalla, Nathaniel Treister, Thomas Sollecito, Brian Schmidt, Lauren L Patton, Kusha Mohammadi, James S Hodges, Michael T Brennan
OBJECTIVE: Examine oral complications 6 months after modern radiation therapy (RT) for head and neck cancer (HNC). METHODS: Prospective multi-center cohort study of HNC patients receiving Intensity-Modulated Radiation Therapy (IMRT) or more advanced RT. Stimulated whole salivary flow, maximal mouth opening, oral mucositis, oral pain, oral health-related quality of life (OH-QOL), and oral hygiene practices, were measured in 372 subjects pre-RT and 216 at 6 months from start of RT...
July 4, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28673655/peak-inspiratory-flow-as-predictor-for-tracheotomy
#18
M Lesnik, J J Sanchez-Guerrero, O De Crouy Chanel, C Hervé, J Guerlain, S Périé
OBJECTIVES: Quantitative evaluation of upper airway obstruction cannot be commonly performed under acute dyspnea, especially in head and neck cancer (HNC); the decision whether or not to perform airway control surgery may be difficult to reach. Peak inspiratory flow (PIF) has been previously demonstrated to be a useful tool to decide on decannulation after HNC surgery. The aim of the present study was to assess the role of PIF as a standardized non-invasive tool in quantifying severe inspiratory dyspnea requiring emergency tracheostomy...
June 30, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28671620/epithelial-to-mesenchymal-transition-in-the-pathogenesis-and-therapy-of-head-and-neck-cancer
#19
REVIEW
Julia Thierauf, Johannes Adrian Veit, Jochen Hess
Head and neck cancer (HNC) is one of the most prevalent human malignancies worldwide, with a high morbidity and mortality. Implementation of interdisciplinary treatment modalities has improved the quality of life, but only minor changes in overall survival have been achieved over the past decades. Main causes for treatment failure are an aggressive and invasive tumor growth in combination with a high degree of intrinsic or acquired treatment resistance. A subset of tumor cells gain these properties during malignant progression by reactivating a complex program of epithelia-to-mesenchymal transition (EMT), which is integral in embryonic development, wound healing, and stem cell behavior...
July 3, 2017: Cancers
https://www.readbyqxmd.com/read/28666335/a-randomized-double-blind-placebo-controlled-multicenter-study-of-a-ginger-extract-in-the-management-of-chemotherapy-induced-nausea-and-vomiting-cinv-in-patients-receiving-high-dose-cisplatin
#20
P Bossi, D Cortinovis, S Fatigoni, M Cossu Rocca, A Fabi, P Seminara, C Ripamonti, S Alfieri, R Granata, C Bergamini, F Agustoni, P Bidoli, F Nolè, M A Pessi, F Macchi, L Michellini, F Montanaro, F Roila
Background: The activity of ginger in the management of chemotherapy-induced nausea and vomiting (CINV) has been suggested, but design inadequacies, heterogeneity of the population, small numbers and poor quality of tested products limit the possibility to offer generalizable results. Patients and methods: We conducted a randomized, double-blind, placebo-controlled, multicenter study in patients planned to receive ≥2 chemotherapy cycles with high dose (>50 mg/m 2 ) cisplatin...
June 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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