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https://www.readbyqxmd.com/read/28214178/validation-of-the-university-of-washington-quality-of-life-chinese-version-uwqol-c-for-head-and-neck-cancer-patients-in-taiwan
#1
Yun-Hsiang Lee, Yeur-Hur Lai, Bevan Yueh, Pen-Yuan Chu, Yen-Ju Chen, Shu-Ching Chen, Cheng-Ping Wang
BACKGROUND/PURPOSE: The purposes of this three-phase study were to: (1) translate and evaluate the burden, content, and face validity of the Chinese version of the University of Washington Quality of Life Scale, version 4 (UWQOL-v4-C); and (2) examine the psychometric properties of the UWQOL-v4-C in oral cancer and laryngeal cancer patients in Taiwan. METHODS: This instrument translation and validation study was part of a major research project. The first phase of this study developed and validated the content of the UWQOL-v4-C...
February 14, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28206871/swallowing-therapy-and-progressive-resistance-training-in-head-and-neck-cancer-patients-undergoing-radiotherapy-treatment-randomized-control-trial-protocol-and-preliminary-data
#2
Sara F Hajdú, Irene Wessel, Christoffer Johansen, Claus A Kristensen, Zahra T Kadkhoda, Christina C Plaschke, Susanne O Dalton
BACKGROUND: Head and neck cancer (HNC) patients are often challenged by treatment induced dysphagia and trismus. Traditionally, rehabilitation is initiated when loss of function has already occurred. There is increasing evidence that it is of benefit to patients to initiate an early rehabilitation process before and during treatment. HNC patients have a unique set of functional challenges such as pre- and post-treatment dysphagia, pain and weight loss. The aim of the trial is to investigate the effects of swallowing and mouth-opening exercises combined with progressive resistance training (PRT) during radiotherapy...
February 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28205306/multi-site-quality-and-variability-analysis-of-3d-fdg-pet-segmentations-based-on-phantom-and-clinical-image-data
#3
Reinhard R Beichel, Brian J Smith, Christian Bauer, Ethan J Ulrich, Payam Ahmadvand, Mikalai M Budzevich, Robert J Gillies, Dmitry Goldgof, Milan Grkovski, Ghassan Hamarneh, Qiao Huang, Paul E Kinahan, Charles M Laymon, James M Mountz, John P Muzi, Mark Muzi, Sadek Nehmeh, Matthew J Oborski, Yongqiang Tan, Binsheng Zhao, John J Sunderland, John M Buatti
PURPOSE: Radiomics utilizes a large number of image-derived features for quantifying tumor characteristics that can in turn be correlated with response and prognosis. Unfortunately, extraction and analysis of such image-based features is subject to measurement variability and bias. The challenge for radiomics is particularly acute in Positron Emission Tomography (PET) where limited resolution, a high noise component related to the limited stochastic nature of the raw data, and the wide variety of reconstruction options confound quantitative feature metrics...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28204992/the-life-experience-of-nutrition-impact-symptoms-during-treatment-for-head-and-neck-cancer-patients-a-systematic-review-and-meta-synthesis
#4
REVIEW
Valentina Bressan, Annamaria Bagnasco, Giuseppe Aleo, Gianluca Catania, Milko P Zanini, Fiona Timmins, Loredana Sasso
PURPOSE: In the literature, there is limited research about the changed meaning of food, the eating and the eating experience during treatment in patients with head and neck cancer. This systematic review includes findings from a qualitative research synthesis to gain a deeper understanding of the influence and experiences of dysphagia, dysgeusia, oral mucositis and xerostomia in head and neck cancer patients (HNC) and suggests recommendations for care practice. METHOD: A systematic review and meta-synthesis techniques were adopted to identify, appraise and synthesize the relevant literature regarding the experience of nutritional symptoms of HNC patients conducted according to the PRISMA guidelines...
February 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28198401/enrichment-of-circulating-head-and-neck-tumour-cells-using-spiral-microfluidic-technology
#5
Arutha Kulasinghe, Thao Huynh Phuoc Tran, Tony Blick, Ken O'Byrne, Erik W Thompson, Majid E Warkiani, Colleen Nelson, Liz Kenny, Chamindie Punyadeera
Whilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this is that the rate of distant metastasis has not changed. Such disseminated disease is reflected in measurable levels of cancer cells in the blood of HNC patients, referred to as circulating tumour cells (CTCs). Numerous marker-independent techniques have been developed for CTC isolation and detection. Recently, microfluidics-based platforms have come to the fore to avoid molecular bias...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197389/adaptive-resistance-to-anti-pd1-therapy-by-tim-3-upregulation-is-mediated-by-the-pi3k-akt-pathway-in-head-and-neck-cancer
#6
Gulidanna Shayan, Raghvendra Srivastava, Jing Li, Nicole Schmitt, Lawrence P Kane, Robert L Ferris
Programmed Death 1 (PD-1) and T cell Ig and mucin domain-3 protein (Tim-3) are immune checkpoint receptors that are expressed on tumor-infiltrating lymphocytes (TIL) in tumor-bearing mice and humans. As anti-PD-1 single agent response rates are only <20% in head and neck squamous cell carcinoma (HNSCC) patients, it is important to understand how multiple inhibitory checkpoint receptors maintain suppressed cellular immunity. One such receptor, Tim-3, activates downstream proliferative pathways through Akt/S6, and is highly expressed in dysfunctional TIL...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28194641/unsupervised-exercise-in-survivors-of-human-papillomavirus-related-head-and-neck-cancer-how-many-can-go-it-alone
#7
Joshua Bauml, Jiyoung Kim, Xiaochen Zhang, Charu Aggarwal, Roger B Cohen, Kathryn Schmitz
PURPOSE: Patients with human papillomavirus (HPV)-related head and neck cancer (HNC) have a better prognosis relative to other types of HNC, making survivorship an emerging and critical issue. Exercise is a core component of survivorship care, but little is known about how many survivors of HPV-related HNC can safely be advised to start exercising on their own, as opposed to needing further evaluation or supervised exercise. METHODS: We utilized guidelines to identify health issues that would indicate value of further evaluation prior to being safely prescribed unsupervised exercise...
February 13, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28187443/analysis-of-the-cancer-genome-atlas-sequencing-data-reveals-novel-properties-of-the-human-papillomavirus-16-genome-in-head-and-neck-squamous-cell-carcinoma
#8
Tara J Nulton, Amy L Olex, Mikhail Dozmorov, Iain M Morgan, Brad Windle
Human papillomavirus (HPV) DNA is detected in up to 80% of oropharyngeal carcinomas (OPC) and this HPV positive disease has reached epidemic proportions. To increase our understanding of the disease, we investigated the status of the HPV16 genome in HPV-positive head and neck cancers (HNC). Raw RNA-Seq and Whole Genome Sequence data from The Cancer Genome Atlas HNC samples were analyzed to gain a full understanding of the HPV genome status for these tumors. Several remarkable and novel observations were made following this analysis...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28187294/comprehensible-knowledge-model-creation-for-cancer-treatment-decision-making
#9
Muhammad Afzal, Maqbool Hussain, Wajahat Ali Khan, Taqdir Ali, Sungyoung Lee, Eui-Nam Huh, Hafiz Farooq Ahmad, Arif Jamshed, Hassan Iqbal, Muhammad Irfan, Manzar Abbas Hydari
BACKGROUND: A wealth of clinical data exists in clinical documents in the form of electronic health records (EHRs). This data can be used for developing knowledge-based recommendation systems that can assist clinicians in clinical decision making and education. One of the big hurdles in developing such systems is the lack of automated mechanisms for knowledge acquisition to enable and educate clinicians in informed decision making. MATERIALS AND METHODS: An automated knowledge acquisition methodology with a comprehensible knowledge model for cancer treatment (CKM-CT) is proposed...
January 29, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28183993/multiparametric-imaging-of-tumor-hypoxia-and-perfusion-with-18-f-fmiso-dynamic-pet-in-head-and-neck-cancer
#10
Milan Grkovski, Heiko Schöder, Nancy Lee, Sean D Carlin, Bradley Jay Beattie, Nadeem Riaz, Jonathan E Leeman, Joseph A O'Donoghue, John Laurence Humm
Tumor hypoxia and perfusion are independent prognostic indicators of patient outcome. We developed the methodology for, and investigated the utility of multiparametric imaging of tumor hypoxia and perfusion with (18)F-fluoromisonidazole (FMISO) dynamic positron emission tomography (dPET) in head and neck cancer (HNC). Methods: 120 HNC patients underwent 0-30 min FMISO dPET in a customized immobilization mask, followed by 10 min static acquisitions starting at 93±6 and 160±13 min post-injection. A total of 248 lesions (≥2 cm(3)) were analyzed...
February 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28183827/measured-adiposity-in-relation-to-head-and-neck-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition
#11
Heather A Ward, Petra A Wark, David C Muller, Annika Steffen, Mattias Johansson, Teresa Norat, Marc J Gunter, Kim Overvad, Christina C Dahm, Jytte Halkjær, Anne Tjønneland, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Sylvie Mesrine, Paul Brennan, Heinz Freisling, Kuanrong Li, Rudolf Kaaks, Antonia Trichopoulou, Pagona Lagiou, Salvatore Panico, Sara Grioni, Rosario Tumino, Paolo Vineis, Domenico Palli, Petra H M Peeters, H Bas Bueno-de-Mesquita, Elisabete Weiderpass, Antonio Agudo, Jose Ramon Quiros, Nerea Larrañaga, Eva Ardanaz, José María Huerta, María-José Sánchez, Goran Laurell, Ingegerd Johansson, Ulla Westin, Peter Wallstrom, Kathryn E Bradbury, Nicholas J Wareham, Kay-Tee Khaw, Clare Pearson, Heiner Boeing, Elio Riboli
BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error. METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22...
February 9, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28168421/screening-for-distress-using-the-distress-thermometer-and-the-university-of-washington-quality-of-life-in-post-treatment-head-and-neck-cancer-survivors
#12
Naseem Ghazali, Brenda Roe, Derek Lowe, Sank Tandon, Terry Jones, James Brown, Richard Shaw, Janet Risk, Simon N Rogers
The primary aim was to determine the efficacy of the Distress Thermometer (DT) in screening for anxiety and mood problems against the University of Washington Quality of Life, version 4 (UWQOL). Secondary aims were to evaluate the association between demographic, clinical and health-related QOL variables with significant distress. Two hundred and sixty one disease-free HNC ambulatory patients attending routine follow-up clinics were prospectively recruited. Both DT and UWQOL were completed pre-consultation...
February 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28164282/incidence-trends-for-potentially-human-papilloma-virus-related-and-unrelated-head-and-neck-cancers-in-france-using-population-based-cancer-registries-data-1980-2012
#13
Karine Jéhannin-Ligier, Aurélien Belot, Anne-Valérie Guizard, Nadine Bossard, Guy Launoy, Zoé Uhry
Human papilloma virus (HPV) has been recently recognised as a carcinogenic factor for a subset of head and neck cancers (HNC). In Europe, France has one of the highest incidence rates of HNC. The aim of this study is to explore changes in HNC incidence in France, potentially in relation with infection by HPV. HNC were classified into two anatomical groups: potentially HPV-related and HPV- unrelated. Trends over the period 1980-2012 were analysed by an age-period-cohort model based on data from eleven French cancer registries...
February 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28161784/benchmark-dft-assessments-cooperativity-and-energy-decomposition-analysis-of-the-hydrogen-bonds-in-hcn-hnc-oligomeric-complexes
#14
Paulo McMiller C de Oliveira, Juliana A B Silva, Ricardo L Longo
Hydrogen cyanide (HCN) and its tautomer hydrogen isocyanide (HNC) are relevant for extraterrestrial chemistry and possible relation to the origin of biomolecules. Several processes and reactions involving these molecules depend on their intermolecular interactions that can lead to aggregates and liquids especially due to the hydrogen bonds. It is thus important to comprehend, to describe, and to quantify their hydrogen bonds, mainly their nature and the cooperativity effects. A systematic study of all linear complexes up to pentamers of HCN and HNC is presented...
February 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28160583/calcified-carotid-artery-atheromas-on-panoramic-radiographs-of-head-and-neck-cancer-patients-before-and-after-radiotherapy
#15
R-L Markman, K-G Conceição-Vasconcelos, T-B Brandão, A-C Prado-Ribeiro, A-R Santos-Silva, M Ajudarte Lopes
BACKGROUND: The aims of this study were to verify if head and neck radiotherapy (RT) is able to induce calcified carotid artery atheroma (CCAA) in a large head and neck cancer (HNC) population and also to compare the socio-demographic and clinical findings of patients with and without CCAA detected on panoramic radiographs. MATERIAL AND METHODS: Panoramic radiographs taken before and after head and neck radiotherapy (RT) of 180 HNC patients were selected and analyzed in order to identify the presence of CCAA...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28156655/a-two-group-study-to-evaluate-the-impact-of-an-educational-handbook-in-the-care-of-patients-with-head-and-neck-cancer-hnc
#16
Areej El-Jawahri, Karen Quinn, Lisa Arcikowski, Gina Chan, Elene Viscosi, Carol Doherty, John Ross Clark, Jennifer S Temel, Lori J Wirth
: 228 Background: Patients undergoing chemoradiotherapy for HNC have a significant symptom burden, psychological distress, and educational needs. We evaluated the impact of an educational handbook integrated into oncology care on patient outcomes. METHODS: We conducted a two group, prospective, longitudinal study. Patients enrolled in group 1 received standard care as a control. Then, patients in group 2 received the intervention of a specialized handbook integrated into weekly visits with oncology clinicians during treatment...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156440/patient-reported-outcomes-pros-in-patients-with-human-papilloma-virus-hpv-positive-versus-negative-head-and-neck-cancer-hnc
#17
Areej El-Jawahri, Karen Quinn, Lisa Arcikowski, Gina Chan, Elene Viscosi, Carol Doherty, John Ross Clark, Lori J Wirth, Jennifer S Temel
: 87 Background: HNC caused by HPV has become an epidemic. Treatment for HNC results in a tremendous symptom burden. The impact of HPV-status on quality of life (QOL) and how this effects illness perception and mood has not been described. We sought to explore differences in PROs in patients with HPV + vs. - HNC. METHODS: This is a secondary analysis of data from a prospective, longitudinal intervention study of 60 patients with newly diagnosed HNC undergoing concurrent chemoradiation...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28155041/informational-needs-of-head-and-neck-cancer-patients
#18
Janet Papadakos, Maurene McQuestion, Anandita Gokhale, Ali Damji, Aileen Trang, Nazek Abdelmutti, Jolie Ringash
The patient journey with head and neck cancer (HNC) is particularly challenging given the physical and functional impact of the cancer and treatment. The ability to perform activities of daily living can be severely compromised and have a profound impact on psychosocial well-being. These complex and long-lasting effects can affect patient quality of life for months to years and the literature shows that information for HNC patients is often insufficient. This observational cross-sectional study utilized survey methodology to investigate the informational needs of HNC patients and the preferred modalities for delivery...
February 2, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28154335/analysis-of-the-risk-factors-for-severe-oral-mucositis-in-head-and-neck-cancer-after-chemoradiotherapy-with-s-1
#19
Akiko Nagatani, Yumiko Ogawa, Tomiko Sunaga, Kazuki Tomura, Yuki Naito, Naokazu Fujii, Takayuki Okabe, Touji Hashimoto, Mari Kogo, Tadanori Sasaki
 Radiotherapy (RT) and chemoradiotherapy (CRT) is widely accepted as the standard treatment for head and neck cancer (HNC). Oral mucositis (OM) often develops as an adverse reaction in HNC patients that receive RT or CRT involving S-1. However, little is known about the risk factors for OM in HNC patients. We retrospectively evaluated patients' pre-treatment clinical data in order to identify the risk factors for severe OM in HNC patients that are treated with RT or CRT involving S-1. We analyzed the cases of 129 patients who received RT or CRT involving S-1 for HNC...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28143871/role-of-host-microrna-hsa-mir-139-3p-in-hpv-16-induced-carcinomas
#20
Malay Kr Sannigrahi, Rajni Sharma, Varinder Singh, Naresh K Panda, Vidya Rattan, Madhu Khullar
PURPOSE: Human papillomavirus 16 (HPV-16) is important risk factor in Head and Neck Cancer (HNC). Studies suggest that microRNAs play an important role in cancer, however, their role in HPV mediated oncogenesis remains largely unknown. We investigated the role of microRNAs with HPV-16 as putative target in HPV-16 mediated cancers. EXPERIMENTAL DESIGN: Using in-silico tools, we identified microRNAs with putative binding sequences on HPV-16 mRNAs. Hsa-miR-139-3p was identified as best candidate miRNA by luciferase reporter assay and was found to be significantly down-regulated in HPV-16 positive tissues and cell lines...
January 31, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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