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https://www.readbyqxmd.com/read/29151175/demographic-clinical-lifestyle-related-and-social-cognitive-correlates-of-physical-activity-in-head-and-neck-cancer-survivors
#1
Laurien M Buffart, Remco de Bree, Martine Altena, Sophie van der Werff, Constance H C Drossaert, Caroline M Speksnijder, Michiel W van den Brekel, Harriët Jager-Wittenaar, Neil K Aaronson, Martijn M Stuiver
PURPOSE: The purpose of the study is to identify demographic, clinical, lifestyle-related, and social-cognitive correlates of physical activity (PA) intention and behavior in head and neck cancer (HNC) survivors using the theory of planned behavior (TPB). METHODS: Data from two cross-sectional studies on correlates of PA in HNC survivors were pooled. Both studies used self-reports to assess PA and social-cognitive correlates. Potential correlates were collected via self-report or medical records...
November 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29145620/head-and-neck-cancer-in-hong-kong
#2
Wai Tong Ng, Edwin C Y Wong, Victor H F Lee, Jimmy Y W Chan, Anne W M Lee
Head and neck cancer is a major cause of morbidity and mortality in Hong Kong. HNC is well-known for its heterogeneity in epidemiology, clinical behavior, clinic-pathological features and patient characteristics. Treatment strategies for this heterogeneous disease vary greatly in different parts of the world, depending on availability of resources, local expertise and experience. Extensive research in head and neck cancer, particularly nasopharyngeal carcinoma, has been conducted in Hong Kong in the past few decades...
November 14, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29143133/association-of-dna-repair-genes-polymorphisms-and-mutations-with-increased-risk-of-head-and-neck-cancer-a-review
#3
REVIEW
Agata Dylawerska, Wojciech Barczak, Anna Wegner, Wojciech Golusinski, Wiktoria Maria Suchorska
DNA repair mechanisms allow maintain genomic stability and proper functioning within the cells. Any aberrations may cause an increased risk of many diseases such as cancer. The most crucial risk factors for head and neck squamous cell carcinoma are behavioral factors, predominantly chronic exposure to tobacco, alcohol addiction, and infection with human papillomavirus or Epstein-Barr virus. These agents can induce DNA damage; therefore, cells must activate appropriate mechanisms in order to function correctly...
November 15, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29137788/ultrasonic-assisted-manufacturing-of-new-hydrogel-nanocomposite-biosorbent-containing-calcium-carbonate-nanoparticles-and-tragacanth-gum-for-removal-of-heavy-metal
#4
Shadpour Mallakpour, Amir Abdolmaleki, Farbod Tabesh
This article reports the first incorporation of calcium carbonate nanoparticles (CC NPs) into tragacanth gum (TG) to prepare a new hydrogel nanocomposite (HNC) system using a green, safe, and eco-friendly method, ultrasound irradiation as an efficient biosorbent of heavy metal ions from wastewater. Morphological studies revealed that the surface of obtained HNCs is rough, homogeneous, and porous-like due to the embedding of CC NPs as well as sonication in comparison to the neat TG which has a smooth surface...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29134990/dft-coupled-with-negf-study-of-ultra-sensitive-hcn-and-hnc-gases-detection-and-distinct-i-v-response-based-on-phosphorene
#5
Jiu Pang, Qun Yang, Xiaosong Ma, Liming Wang, Chunjian Tan, Daxi Xiong, Huaiyu Ye, Xianping Chen
The sensing performances of pristine and X-doped phosphorene substrates (X = Al, Si, and S atoms) toward the adsorption of the toxic gases HCN and HNC were systematically investigated by first-principles simulations. The numerical results show that the pristine phosphorene is sensitive to HCN and HNC molecules with moderate adsorption energy, excellent charge transfer, high sensitivity and selectivity, implying its potential applications as excellent HCN and HNC sensors. In addition, the Al-doped phosphorene exhibits extremely high reactive activity toward HCN and HNC gases; thus, it has potential for use as a metal-free catalyst for activating or catalyzing HCN or HNC adsorbates...
November 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29133573/the-rars-mad1l1-fusion-gene-induces-cancer-stem-cell-like-properties-and-therapeutic-resistance-in-nasopharyngeal-carcinoma
#6
Qian Zhong, Zhihua Liu, Zhi-Rui Lin, Ze-Dong Hu, Li Yuan, Yan-Min Liu, Ai-Jun Zhou, Li-Hua Xu, Li-Juan Hu, Zi-Feng Wang, Xin Yuan Guan, Jia-Jie Hao, Vivian Wai Yan Lui, Ling Guo, Hai-Qiang Mai, Ming-Yuan Chen, Fei Han, Yun-Fei Xia, Jennifer R Grandis, Xing Zhang, Mu-Sheng Zeng
PURPOSE: Nasopharyngeal carcinoma (NPC) is most common head and neck cancer in Southeast Asia. Because local recurrence and distant metastasis are still the main causes of NPC treatment failure, it is urgent to identify new tumor markers and therapeutic targets for advanced NPC. EXPERIMENTAL DESIGN: RNA-seq was applied to look for interchromosome translocation in NPC. PCR, FISH and immunoprecipitation were used to examine the fusion gene expression at RNA, DNA, and protein levels in NPC biopsies...
November 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29126314/cost-effectiveness-analysis-of-nivolumab-for-treatment-of-platinum-resistant-recurrent-or-metastatic-squamous-cell-carcinoma-of-the-head-and-neck
#7
Kathryn R Tringale, Kate T Carroll, Kaveh Zakeri, Assuntina G Sacco, Linda Barnachea, James D Murphy
Background: The CheckMate 141 trial found that nivolumab improved survival for patients with recurrent or metastatic head and neck cancer (HNC). Despite the improved survival, nivolumab is much more expensive than standard therapies. This study assesses the cost-effectiveness of nivolumab for the treatment of HNC. Methods: We constructed a Markov model to simulate treatment with nivolumab or standard single-agent therapy for patients with recurrent or metastatic platinum-refractory HNC...
November 3, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29121151/association-between-cognitive-function-and-quality-of-life-in-patients-with-head-and-neck-cancer
#8
Amy M Williams, Jamie Lindholm, Diana Cook, Farzan Siddiqui, Tamer A Ghanem, Steven S Chang
Importance: There is a dearth of research examining the associations between cognitive function and quality of life (QoL) in patients with head and neck cancer (HNC), despite much research examining QoL and some research examining cognitive function in this population. Objective: To identify the associations between cognitive functioning and QoL in patients prior to treatment for HNC within a multidisciplinary care team. Design, Setting, and Participants: Case series with planned data collection of cognitive function, QoL, and psychosocial variables at an urban Midwest academic medical center including 83 patients with a diagnosis of HNC between August 2015 and December 2016 who underwent a pretreatment assessment with a clinical health psychologist and a speech and language pathologist...
November 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29114887/cough-strength-and-expiratory-force-in-aspirating-and-nonaspirating-postradiation-head-and-neck-cancer-survivors
#9
Katherine A Hutcheson, Martha P Barrow, Carla L Warneke, Yiqun Wang, George Eapen, Stephen Y Lai, Denise A Barringer, Emily K Plowman, Jan S Lewin
OBJECTIVE: Expiratory functions that clear aspiration from the airway are compromised in patients with neurogenic dysphagia for whom cough and expiratory force may be impaired by the primary disease process. The relationship between expiratory function, cough, and aspiration is less clear in head and neck cancer (HNC) survivors for whom the disease process does not directly impact the lower respiratory system. Our objective was to compare mechanisms of airway clearance (expiratory force and cough) with aspiration status in postradiated HNC survivors...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29114180/head-and-neck-cancer-tumor-segmentation-using-support-vector-machine-in-dynamic-contrast-enhanced-mri
#10
Wei Deng, Liangping Luo, Xiaoyi Lin, Tianqi Fang, Dexiang Liu, Guo Dan, Hanwei Chen
Objective: We aimed to propose an automatic method based on Support Vector Machine (SVM) and Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to segment the tumor lesions of head and neck cancer (HNC). Materials and Methods: 120 DCE-MRI samples were collected. Five curve features and two principal components of the normalized time-intensity curve (TIC) in 80 samples were calculated as the dataset in training three SVM classifiers. The other 40 samples were used as the testing dataset...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29112234/impact-of-the-insurance-type-of-head-and-neck-cancer-patients-on-their-hospitalization-utilization-patterns
#11
Avni Gupta, Stephen T Sonis, Eric B Schneider, Alessandro Villa
BACKGROUND: Head and neck cancer (HNC) patients with Medicaid, Medicare, or no insurance show poor outcomes in comparison with privately insured patients. It was hypothesized that nonprivate insurance coverage biases the selection of the treatment site to favor hospitals that are not associated with optimum treatment outcomes. This study assessed the relation between the insurance type of HNC patients and the hospital type for inpatient care. METHODS: Adult HNC patients were identified from the Nationwide Inpatient Sample (2012 and 2013)...
November 7, 2017: Cancer
https://www.readbyqxmd.com/read/29111172/nutritional-counseling-with-or-without-systematic-use-of-oral-nutritional-supplements-in-head-and-neck-cancer-patients-undergoing-radiotherapy
#12
Emanuele Cereda, Silvia Cappello, Sara Colombo, Catherine Klersy, Ilaria Imarisio, Annalisa Turri, Marilisa Caraccia, Valeria Borioli, Teresa Monaco, Marco Benazzo, Paolo Pedrazzoli, Franco Corbella, Riccardo Caccialanza
BACKGROUND: To evaluate the benefit of oral nutritional supplements (ONS) in addition to nutritional counseling in head and neck cancer (HNC) patients undergoing radiotherapy (RT). METHODS: In a single-center, randomized, pragmatic, parallel-group controlled trial (ClinicalTrials.gov: NCT02055833; February 2014-August 2016), 159 newly diagnosed HNC patients suitable for to RT regardless of previous surgery and induction chemotherapy were randomly assigned to nutritional counseling in combination with ONS (N = 78) or without ONS (N = 81) from the start of RT and continuing for up to 3 months after its end...
October 27, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29103742/percutaneous-endoscopic-gastrostomy-feeding-of-locally-advanced-oro-pharygo-laryngeal-cancer-patients-blenderized-or-commercial-food
#13
Pyrros Papakostas, Georgia Tsaousi, George Stavrou, Dimitrios Rachovitsas, Gavriil Tsiropoulos, Constantina Rova, Ioannis Konstantinidis, Antonios Michalopoulos, Vasilios Grosomanidis, Katerina Kotzampassi
OBJECTIVES: Head and neck cancer patients commonly suffer from severe malnutrition at the time of tentative diagnosis. Percutaneous Endoscopic Gastrostomy [PEG] feeding is now considered as an efficient tool to reduce nutritional deterioration alongside concurrent treatment. We undertook the challenge to retrospectively evaluate the impact of a commercial, disease-specific, feeding formula [Supportan, Fresenius Kabi, Hellas] versus blenderized family food on nutritional outcome. MATERIALS AND METHODS: This is a retrospective analysis of prospectively collected nutritional and anthropometric data at the time of PEG placement, at the 8th week [after treatment termination] and at 8 months [6mo of recovery from treatment]...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29103741/the-effect-of-home-based-program-and-outpatient-physical-therapy-in-patients-with-head-and-neck-cancer-a-randomized-controlled-trial
#14
Tsui-Ling Su, An-Ni Chen, Chau-Peng Leong, Yu-Chi Huang, Chia-Wei Chiang, I-Hsuan Chen, Yan-Yuh Lee
OBJECTIVES: Physical therapy improves outcomes for patients with head and neck cancer (HNC) but home-based program (HBP) has not yet been investigated thoroughly. This study compared a HBP with outpatient physical therapy (OPT). METHODS: This trial categorized patients with primary HNC into OPT and HBP groups. The patients in the HBP group received home-based therapy once a day for 5 days per week. By contrast, the OPT group received various physical therapies, including aerobic, anaerobic, and stretching therapies, twice per week, plus a thrice-weekly home-based therapy that similarly consisted of aerobic, anaerobic, and stretching exercises...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29098398/evaluation-of-an-automated-swallow-detection-algorithm-using-visual-biofeedback-in-healthy-adults-and-head-and-neck-cancer-survivors
#15
Gabriela Constantinescu, Kristina Kuffel, Daniel Aalto, William Hodgetts, Jana Rieger
Mobile health (mHealth) technologies may offer an opportunity to address longstanding clinical challenges, such as access and adherence to swallowing therapy. Mobili-T(®) is an mHealth device that uses surface electromyography (sEMG) to provide biofeedback on submental muscles activity during exercise. An automated swallow-detection algorithm was developed for Mobili-T(®). This study evaluated the performance of the swallow-detection algorithm. Ten healthy participants and 10 head and neck cancer (HNC) patients were fitted with the device...
November 2, 2017: Dysphagia
https://www.readbyqxmd.com/read/29097782/disease-relevant-signalling-pathways-in-head-and-neck-cancer-taspase1-s-proteolytic-activity-fine-tunes-tfiia-function
#16
Alena Gribko, Angelina Hahlbrock, Sebastian Strieth, Sven Becker, Jan Hagemann, Max Deichelbohrer, Andreas Hildebrandt, Negusse Habtemichael, Désirée Wünsch
Head and neck cancer (HNC) is the seventh most common malignancy in the world and its prevailing form, the head and neck squamous cell carcinoma (HNSCC), is characterized as aggressive and invasive cancer type. The transcription factor II A (TFIIA), initially described as general regulator of RNA polymerase II-dependent transcription, is part of complex transcriptional networks also controlling mammalian head morphogenesis. Posttranslational cleavage of the TFIIA precursor by the oncologically relevant protease Taspase1 is crucial in this process...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29090383/patients-with-advanced-periodontal-disease-before-intensity-modulated-radiation-therapy-are-prone-to-develop-bone-healing-problems-a-2-year-prospective-follow-up-study
#17
Jennifer M Schuurhuis, Monique A Stokman, Max J H Witjes, Harry Reintsema, Johannes A Langendijk, Arjan Vissink, Frederik K L Spijkervet
PURPOSE: Intensity-modulated radiation therapy (IMRT) has changed radiation treatment of head and neck cancer (HNC). However, it is still unclear if and how IMRT changes oral morbidity outcomes. In this prospective study, we assessed the outcome of reducing post-IMRT sequelae by means of pre-radiation dental screening and eliminating oral foci. METHODS: All consecutive dentate patients > 18 years, diagnosed with primary oral or oropharyngeal carcinoma, referred for pre-treatment dental screening between May 2011 and May 2013, were included and followed for 2 years...
October 31, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29090290/associative-detachment-ad-paths-for-h-and-cn-in-the-gas-phase-astrophysical-implications
#18
Stanka V Jerosimić, Franco A Gianturco, Roland Wester
The direct dynamical paths leading to Associative Detachment (AD) in the gas-phase, and specifically in the low-temperature regions of the Dark Molecular Clouds (DMC) in the ISM, or in cold trap laboratory experiments, are investigated with quantum chemical methods by using a high-level multi-reference Configuration Interaction (CI) approach that employs single and double excitations plus Davidson perturbative correction [MRSDCI(Q)] and the d-aug-cc-pV5Z basis set. The potential energy curves for H + CN(-) are constructed for different directions of the H partner approaching the CN(-) anion within the framework of the Born-Oppenheimer approximation...
November 1, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29081270/home-based-telehealth-service-for-swallowing-and-nutrition-management-following-head-and-neck-cancer-treatment
#19
Annette Collins, Clare L Burns, Elizabeth C Ward, Tracy Comans, Claire Blake, Lizbeth Kenny, Phil Greenup, Daniel Best
Introduction Following (chemo)radiotherapy (C/RT) for head and neck cancer (HNC), patients return to hospital for regular outpatient reviews with speech pathology (SP) and nutrition and dietetics (ND) for acute symptom monitoring, nutritional management, and swallowing and communication rehabilitation. The aim of the current study was to determine the feasibility of a home-based telehealth model for delivering SP and ND reviews, to provide patients with more convenient access to these appointments. Methods Service outcomes, costs, and consumer satisfaction were examined across 30 matched participants: 15 supported via the standard model of care (SMOC), and 15 via the home-based telehealth model of care (TMOC)...
December 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29079897/the-case-volume-issue-in-head-and-neck-oncology
#20
REVIEW
Salvatore Alfieri, Ester Orlandi, Paolo Bossi
In the past few years, several evidences reported better outcomes, in terms of reduced toxicities and longer survival, for head and neck cancer (HNC) patients when "regionalized," namely if they are managed at "high-volume" cancer referral centers (CRC). The benefit of case volume has been demonstrated in HNC patients primarily treated with surgery and in those receiving curative radiotherapy and chemotherapy. Many factors could explain these positive results: organization, facilities, processes of care, quality assurance programs, professional expertise, technology, and patient referral bias...
October 27, 2017: Current Treatment Options in Oncology
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