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https://www.readbyqxmd.com/read/28921843/potential-proton-and-photon-dose-degradation-in-advanced-head-and-neck-cancer-patients-by-intratherapy-changes
#1
Kristin Stützer, Annika Jakobi, Anna Bandurska-Luque, Steffen Barczyk, Carolin Arnsmeyer, Steffen Löck, Christian Richter
PURPOSE: Evaluation of dose degradation by anatomic changes for head-and-neck cancer (HNC) intensity-modulated proton therapy (IMPT) relative to intensity-modulated photon therapy (IMRT) and identification of potential indicators for IMPT treatment plan adaptation. METHODS: For 31 advanced HNC datasets, IMPT and IMRT plans were recalculated on a computed tomography scan (CT) taken after about 4 weeks of therapy. Dose parameter changes were determined for the organs at risk (OARs) spinal cord, brain stem, parotid glands, brachial plexus, and mandible, for the clinical target volume (CTV) and the healthy tissue outside planning target volume (PTV)...
September 18, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28904066/pd-1-status-in-cd8-t-cells-associates-with-survival-and-anti-pd-1-therapeutic-outcomes-in-head-and-neck-cancer
#2
Benjamin A Kansy, Fernando Concha-Benavente, Raghvendra M Srivastava, Hyun-Bae Jie, Gulidanna Shayan, Yu Lei, Jessica Moskovitz, Jennifer Moy, Jing Li, Sven Brandau, Stephan Lang, Nicole C Schmitt, Gordon J Freeman, William E Gooding, David A Clump, Robert L Ferris
Improved understanding of expression of immune checkpoint receptors (ICR) on tumor-infiltrating lymphocytes (TIL) may facilitate more effective immunotherapy in head and neck cancer (HNC) patients. A higher frequency of PD-1(+) TIL has been reported in human papillomavirus (HPV)(+) HNC patients, despite the role of PD-1 in T cell exhaustion. This discordance led us to hypothesize that the extent of PD-1 expression more accurately defines T cell function and prognostic impact, since PD-1(high) T cells may be more exhausted than PD-1(low) T cells and may influence clinical outcome and response to anti-PD-1 immunotherapy...
September 13, 2017: Cancer Research
https://www.readbyqxmd.com/read/28887707/correlations-between-patient-reported-dysphagia-screening-and-penetration-aspiration-scores-in-head-and-neck-cancer-patients-post-oncological-treatment
#3
Johanna Hedström, Lisa Tuomi, Caterina Finizia, Caroline Olsson
Dysphagia is a common and severe toxicity after oncological treatment of head and neck cancer (HNC). The study aim was to investigate relationships between patient-reported dysphagia and clinically measured swallowing function in HNC after modern curative radiotherapy with or without chemotherapy to identify possible alarm symptoms for clinically manifest dysphagia. Patients with tumors of the tonsil, base of tongue, hypopharynx, and larynx treated in 2007-2015 were assessed for dysphagia post-treatment by telephone interview and videofluoroscopy (VFS)...
September 8, 2017: Dysphagia
https://www.readbyqxmd.com/read/28884146/optimizing-respiratory-swallowing-coordination-in-patients-with-oropharyngeal-head-and-neck-cancer
#4
Bonnie Martin-Harris, Kendrea L Focht Garand, David McFarland
Swallowing impairment (dysphagia) represents the highest functional morbidity in oropharyngeal (OP) head and neck (HNC) treated either with surgical approaches followed by radiation or with more recent organ preservation protocols, including combined chemotherapy and radiation. Despite the promising overall increasing survival rates, swallowing impairments remain chronic, are often resistant to traditional swallowing therapy, and have devastating consequences on health and well-being. The respiratory-swallow cross-system approach presented here extends beyond traditional swallowing interventions that commonly targets muscles and structures alone, and is instead, directed toward the re-establishment of optimal respiratory-swallowing coordination...
July 2017: Perspectives of the ASHA special interest groups
https://www.readbyqxmd.com/read/28882958/treatment-of-squamous-cell-carcinoma-of-the-esophagus-synchronously-associated-with-head-and-neck-cancer
#5
Masaru Morita, Akinori Egashira, Y U Nakaji, Masaki Kagawa, Masahiko Sugiyama, Daisuke Yoshida, Mitsuhiko Ota, Masahiko Ikebe, Muneyuki Masuda, Yojiro Inoue, Naonobu Kunitake, Yasushi Toh
BACKGROUND/AIM: The aim of this study was to clarify the treatment strategy for synchronous squamous cell carcinoma of the esophagus (ESCC) and head and neck cancer (HNC). PATIENTS AND METHODS: Treatment outcomes of 91 patients with synchronous ESCC and HNC were evaluated. Thirty-eight patients received simultaneous definitive chemoradiotherapy (CRT) and 15 patients underwent simultaneous resection. RESULTS: Among the patients who received simultaneous CRT, adverse events (grade 3-5) were recognized in 14 patients (40%), including one case of death due to aspiration pneumonia...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28875091/demographics-of-head-and-neck-cancer-patients-a-single-institution-experience
#6
George S Stoyanov, Martina Kitanova, Deyan L Dzhenkov, Peter Ghenev, Nikolay Sapundzhiev
Introduction Head and neck cancer (HNC) comprises a diverse group of oncological entities, originating from various tissue types and organ localizations, situated in the topographical regions of the head and neck (H&N). This single institution retrospective study was aimed at establishing the HNC patient demographics and categorizing the individual incidence of H&N malignancies, regarding their organ of origin and main histopathological type. Materials and methods All histologically verified cases of HNC from a single tertiary referral center were reviewed in a descriptive retrospective manner...
July 2, 2017: Curēus
https://www.readbyqxmd.com/read/28865046/prospective-experience-of-percutaneous-endoscopic-gastrostomy-tubes-placed-by-otorhinolaryngologist-head-and-neck-surgeons-%C3%A2-safe-and-efficacious
#7
Johanna Ruohoalho, Katri Aro, Antti A Mäkitie, Timo Atula, Aaro Haapaniemi, Harri Keski-Säntti, Leena Kylänpää, Annika Takala, Leif J Bäck
Percutaneous endoscopic gastrostomy (PEG) is often the treatment of choice in head and neck cancer (HNC) patients needing long-term nutritional support. Prospective studies on PEG tube placement in an otorhinolaryngologist service are lacking. At our hospital, otolaryngologist-head and neck (ORL-HN) surgeons-have performed PEG insertions for HNC patients since 2008. We prospectively analyzed 127 consecutive HNC patients who received their PEG tubes at the Department of Otorhinolaryngology-head and neck surgery, and evaluated the outcome of PEG tube insertions performed by ORL-HN surgeons...
September 1, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28862204/epidemiological-profile-of-head-and-neck-cancer-patients-in-western-uttar-pradesh-and-analysis-of-distributions-of-risk-factors-in-relation-to-site-of-tumor
#8
Mohammad Shadab Alam, Shahid Ali Siddiqui, Roshan Perween
BACKGROUND: Head and neck cancers (HNCs) are a major form of cancers in India. The spectrum varies from place to place within the country because of significant diversified risk factors. AIMS AND OBJECTIVE: To study, epidemiology and risk factors of HNC patients from Western Uttar Pradesh and to find out the correlation between risk factors and different anatomical regions involved. MATERIALS AND METHODS: All patients with histologically confirmed diagnoses of HNC between January 2011 and December 2013 were selected from hospital records...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28860859/head-and-neck-cancer-improving-outcomes-with-a-multidisciplinary-approach
#9
REVIEW
Cristiana Lo Nigro, Nerina Denaro, Anna Merlotti, Marco Merlano
For early-stage head and neck cancer (HNC), surgery (S) or radiotherapy (RT) is a standard treatment. The multidisciplinary approach, which includes multimodality treatment with S followed by RT, with or without chemotherapy (CT) or concurrent chemoradiotherapy (CRT), is required for locally advanced head and neck cancer (LAHNC). CRT improves prognosis, locoregional control (LRC), and organ function in LAHNC, compared to RT alone. Prognosis in recurrent/metastatic HNC (R/M HNC) is dismal. Platinum-based CT, combined with the anti-Epidermal Growth Factor Receptor (EGFR) antibody (Ab) cetuximab, is used in first-line setting, while no further validated options are available at progression...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28857394/patterns-of-stress-coping-and-depression-among-patients-with-head-and-neck-cancer-a-japanese-cross-sectional-study
#10
Kanako Ichikura, Aya Yamashita, Taro Sugimoto, Seiji Kishimoto, Eisuke Matsushima
OBJECTIVE: Patients with head and neck cancer (HNC) experience many stressful problems with breathing, eating, swallowing, and/or speaking. The aim of this study was to (1) identify the clusters of HNC patients based on their stress coping strategies, and (2) evaluate the differences in clinical data and depression between the identified HNC patients' coping clusters. METHODS: We conducted a single-center, cross-sectional study with self-completed questionnaires for patients with HNC between April and August 2013...
August 31, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28857306/the-effect-of-targeted-therapy-on-recruited-cancer-stem-cells-in-a-head-and-neck-carcinoma-model
#11
Loredana G Marcu, David Marcu
OBJECTIVE: Head and neck cancers (HNC) are known for their repopulation ability driven by cancer stem cells (CSCs). While a small fraction of CSCs proliferates, there are quiescent CSCs that are long-lived and reside outside the cell cycle. Recruitment of quiescent CSCs into the cycle occurs as a response to cell loss and their proliferation may lead to treatment failure. Therefore, CSCs require a more targeted approach to be destroyed. An agent that sensitizes CSC response to treatment is all-trans-retinoic acid (ATRA)...
August 30, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28851901/investigating-the-association-between-alcohol-and-risk-of-head-and-neck-cancer-in-taiwan
#12
Cheng-Chih Huang, Jenn-Ren Hsiao, Wei-Ting Lee, Yao-Chou Lee, Chun-Yen Ou, Chan-Chi Chang, Yu-Cheng Lu, Jehn-Shyun Huang, Tung-Yiu Wong, Ken-Chung Chen, Sen-Tien Tsai, Sheen-Yie Fang, Jiunn-Liang Wu, Yuan-Hua Wu, Wei-Ting Hsueh, Chia-Jui Yen, Shang-Yin Wu, Jang-Yang Chang, Chen-Lin Lin, Yi-Hui Wang, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S Chang
Although alcohol is an established risk factor of head and neck cancer (HNC), insufficiencies exist in the literature in several aspects. We analyzed detailed alcohol consumption data (amount and type of alcoholic beverage) of 811 HNC patients and 940 controls to evaluate the association between alcohol and HNC by HNC sites and by genotypes of ADH1B and ALDH2. Alcohol was associated with an increased HNC risk in a dose-response relationship, with the highest risk observed for hypopharyngeal cancer, followed by oropharyngeal and laryngeal cancers...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840980/is-definitive-concurrent-chemoradiotherapy-effective-for-locally-advanced-head-and-neck-cancer-in-the-elderly-aged%C3%A2-%C3%A2-%C3%A2-75-years-a-single-institute-retrospective-cohort-study
#13
Kuan-Ming Lai, Jen-Tsun Lin, Hsueh-Ju Lu, Chia-Chun Liang, Mu-Kuan Chen
BACKGROUND: Definitive chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer (HNC). However, for very elderly patients, the comparison of benefit/risk between definitive radiotherapy (RT) with and without systemic chemotherapy was equivocal. PATIENTS AND METHODS: The study was a single-institute, retrospective, cohort study. Seventy patients aged ≥75 years who had a locally advanced HNC were enrolled. The patients were divided into those with CRT and those with RT alone...
August 25, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28834021/multi-isocentric-4%C3%AF-volumetric-modulated-arc-therapy-approach-for-head-and-neck-cancer
#14
Vallinayagam Shanmuga Subramanian, Vellaiyan Subramani, Srinivas Chilukuri, Murugesan Kathirvel, Gandhi Arun, Shanmugam Thirumalai Swamy, Kala Subramanian, Antonella Fogliata, Luca Cozzi
OBJECTIVES: To explore the feasibility of multi-isocentric 4π volumetric-modulated arc therapy (MI4π-VMAT) for the complex targets of head and neck cancers. METHODS: Twenty-five previously treated patients of HNC underwent re-planning to improve the dose distributions with either coplanar VMAT technique (CP-VMAT) or noncoplanar MI4π-VMAT plans. The latter, involving 3-6 noncoplanar arcs and 2-3 isocenters were re-optimized using the same priorities and objectives...
August 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28826628/brainstem-dose-is-associated-with-patient-reported-acute-fatigue-in-head-and-neck-cancer-radiation-therapy
#15
Matthew J Ferris, Jim Zhong, Jeffrey M Switchenko, Kristin A Higgins, Richard J Cassidy, Mark W McDonald, Bree R Eaton, Kirtesh R Patel, Conor E Steuer, H Michael Baddour, Andrew H Miller, Deborah W Bruner, Canhua Xiao, Jonathan J Beitler
BACKGROUND AND PURPOSE: Radiation (RT) dose to the central nervous system (CNS) has been implicated as a contributor to treatment-related fatigue in head and neck cancer (HNC) patients undergoing radiation therapy (RT). This study evaluates the association of RT dose to CNS structures with patient-reported (PRO) fatigue scores in a population of HNC patients. MATERIALS AND METHODS: At pre-RT (baseline), 6th week of RT, and 1-month post-RT time points, Multidimensional Fatigue Inventory (MFI-20) scores were prospectively obtained from 124 patients undergoing definitive treatment for HNC...
August 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28815324/alcohol-and-head-and-neck-cancer
#16
Daisuke Kawakita, Keitaro Matsuo
In this article, we reviewed the association between alcohol drinking and head and neck cancer (HNC) and its subsites, using the available literature. Alcohol drinking is an established risk factor for HNC, and this association may be stronger among cancers of the oropharynx and hypopharynx than the oral cavity or larynx. In addition, higher alcohol consumption over a shorter period was more harmful than fewer alcohol consumption over a longer period, and the most frequently consumed alcoholic beverages in a population is likely to be associated with the highest risk of HNC in that population...
August 16, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28812214/the-role-of-human-papillomavirus-on-the-prognosis-and-treatment-of-oropharyngeal-carcinoma
#17
Nicholas Fung, Farhoud Faraji, Hyunseok Kang, Carole Fakhry
Human papillomavirus positive oropharyngeal cancer (HPV-positive OPC) is a distinct subtype of head and neck carcinoma (HNC) distinguished from HPV-negative HNC by its risk factor profile, clinical behavior, and molecular biology. Compared to HPV-negative HNC, HPV-positive OPC exhibits significantly better prognosis and an enhanced response to treatment. Recognition of the survival benefit of HPV-positive tumors has led to therapeutic de-intensification strategies aiming to mitigate treatment-related toxicities while maintaining high response rates...
August 15, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28801876/tumor-dna-an-emerging-biomarker-in-head-and-neck-cancer
#18
Joseph A Bellairs, Rifat Hasina, Nishant Agrawal
Head and neck cancer (HNC) includes a diverse range of malignancies arising commonly from mucosal epithelia of the upper aerodigestive tract. Head and neck squamous cell carcinoma (HNSCC), the most common form of HNC, develops in the oral cavity, pharynx, and larynx and is associated with tobacco exposure, alcohol abuse, and infection with oncogenic viruses. Despite global advances in cancer care, HNSCC often presents with advanced disease and is associated with poor 5-year survival of ~50%. Genotyping tumor tissue to guide clinical decision-making is becoming commonplace in modern oncology, but in the management of HNSCC, tissue biopsies with cytopathology or histopathology remain the mainstay for diagnosis...
August 12, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28800444/do-parental-adhd-symptoms-reduce-the-efficacy-of-parent-training-for-preschool-adhd-a-secondary-analysis-of-a-randomized-controlled-trial
#19
Rex Forehand, Justin Parent, Virginia D Peisch, Edmund Sonuga-Barke, Nicholas Long, Nicole Lafko Breslend, Howard B Abikoff
Previous studies have suggested that children with Attention-Deficit/Hyperactivity Disorder (ADHD) may benefit less from behavioral parent training (BPT) if their parents have high levels of ADHD symptoms. We conducted a secondary analysis of data from a randomized controlled trial to test the hypothesis that parental ADHD symptoms reduce the efficacy of two BPT programs in a sample of preschoolers with ADHD. One intervention was specifically designed for children with ADHD (NFPP: New Forest Parenting Programme) and one was designed for children with Oppositional Defiant Disorder (ODD) (HNC: Helping the Noncompliant Child)...
October 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28799372/matrix-isolation-and-ab-initio-study-on-hcn-co2-system-and-its-radiation-induced-transformations-spectroscopic-evidence-for-hcn%C3%A2-co2-and-trans-hcnh%C3%A2-co2-complexes
#20
Svetlana V Kameneva, Daniil A Tyurin, Kirill B Nuzhdin, Vladimir I Feldman
Spectroscopic characteristics and X-ray induced transformations of the HCN⋯CO2 complex in solid Ar and Kr matrices were studied by FTIR spectroscopy and ab initio calculations at the CCSD(T) level. The complex was prepared by deposition of the HCN/CO2/Ng gas mixtures (Ng = Ar or Kr). The comparison of the experiment and calculations prove formation of a linear, H-bonded NCH⋯OCO complex with a substantial red shift of the C-H stretching band and a blue shift of the H-C-N bending band in respect to the monomer...
December 7, 2016: Journal of Chemical Physics
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