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https://www.readbyqxmd.com/read/27903972/gdf15-contributes-to-radioresistance-and-cancer-stemness-of-head-and-neck-cancer-by-regulating-cellular-reactive-oxygen-species-via-a-smad-associated-signaling-pathway
#1
Yan-Liang Li, Joseph T Chang, Li-Yu Lee, Kang-Hsing Fan, Ya-Ching Lu, Yi-Chen Li, Chang-Hsu Chiang, Guo-Rung You, Hsin-Ying Chen, Ann-Joy Cheng
Radiotherapy is an integral part for the treatment of head and neck cancer (HNC), while radioresistance is a major cause leads to treatment failure. GDF15, a member of the TGF-β superfamily, is hypothesized to participate in various types of homeostasis. However, the potential role of this molecule in regulation of radiosensitivity remains unclear. In this study, we demonstrated that GDF15 contributed to radioresistance of HNC, as determined by both gain- and lost-of-functional experiments. These results were achieved by the induction of mitochondrial membrane potential and suppression of intracellular reactive oxygen species (ROS)...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901488/cancer-associated-fibroblasts-promote-cancer-cell-growth-through-a-mir-7-rassf2-par-4-axis-in-the-tumor-microenvironment
#2
Zongze Shen, Xing Qin, Ming Yan, Rongrong Li, Gang Chen, Jianjun Zhang, Wantao Chen
Cancer-associated fibroblasts (CAFs), a major component of cancer stroma, play an important role in cancer progression but little is known about how CAFs affect tumorigenesis and development. MicroRNAs (miRNAs) are small non-coding RNAs that can negatively regulate target mRNA expression at post-transcriptional levels. In head and neck cancer (HNC), our analysis of miRNA arrays showed that miR-7, miR-196 and miR-335 were significantly up-regulated in CAFs when compared with their paired normal fibroblasts (NFs)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901485/mir-146a-rs2910164-polymorphism-and-head-and-neck-carcinoma-risk-a-meta-analysis-based-on-10-case-control-studies
#3
Zhaolan Xiang, Jue Song, Xianlu Zhuo, Qi Li, Xueyuan Zhang
Two recent meta-analyses have been conducted on the relationship between miR-146a polymorphism (rs2910164) and head and neck cancer (HNC) risk. However, they have yielded conflicting results. Hence, the aim of the present study was to conduct a quantitative updated meta-analysis addressing this subject. Eligible studies up to Sep 2016 were retrieved and screened from the bio-databases and then essential data were extracted for data analysis. Next, subgroup analyses on ethnicity, source of controls, sample size, and genotyping method were also carried out...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27897274/modelling-tumour-volume-variations-in-head-and-neck-cancer-magnetic-resonance-imaging-contribution-for-patients-undergoing-induction-chemotherapy
#4
N Dinapoli, T Tartaglione, F Bussu, R Autorino, F Miccichè, M Sciandra, E Visconti, C Colosimo, G Paludetti, V Valentini
Primary tumour volume evaluation has predictive value for estimating survival outcomes. Using volumetric data acquired by MRI in patients undergoing induction chemotherapy (IC) these outcomes were estimated before the radiotherapy course in head and neck cancer (HNC) patients. MRI performed before and after IC in 36 locally advanced HNC patients were analysed to measure primary tumour volume. The two volumes were correlated using the linear-log ratio (LLR) between the volume in the first MRI and the volume in the second...
November 29, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27889257/translation-and-cultural-adaptation-of-the-shame-and-stigma-scale-sss-into-portuguese-brazil-to-evaluate-patients-with-head-and-neck-cancer
#5
William Eduardo Pirola, Bianca Sakamoto Ribeiro Paiva, Eliane Marçon Barroso, David W Kissane, Claudia Valéria Maseti Pimenta Serrano, Carlos Eduardo Paiva
INTRODUCTION: Head and Neck Cancer (HNC) is the sixth leading cause of death from cancer worldwide and its treatment may involve surgery, chemotherapy and/or radiation therapy. The surgical procedure may cause mutilating sequelae, that can alter patient self-image. Thus, HNC is often connected to the negative stigma with decreased quality of life. Few studies assess the social stigma and shame perceived by patients with HNC. OBJECTIVE: To perform the translation and cultural adaptation of the Shame and Stigma Scale (SSS) into Portuguese (Brazil)...
November 9, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27881885/acyclic-nucleoside-phosphonates-containing-the-amide-bond
#6
Iwona E Głowacka, Dorota G Piotrowska, Graciela Andrei, Dominique Schols, Robert Snoeck, Andrzej E Wróblewski
ABSTRACT: To study the influence of a linker rigidity and donor-acceptor properties, the P-CH2-O-CHR- fragment in acyclic nucleoside phosphonates (e.g., acyclovir, tenofovir) was replaced by the P-CH2-HN-C(O)- residue. The respective phosphonates were synthesized in good yields by coupling the straight chain of ω-aminophosphonates and nucleobase-derived acetic acids with EDC. Based on the (1)H and (13)C NMR data, the unrestricted rotation within the methylene and 1,2-ethylidene linkers in phosphonates from series a and b was confirmed...
2016: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/27877135/metabolomics-of-head-and-neck-cancer-a-mini-review
#7
REVIEW
Jae M Shin, Pachiyappan Kamarajan, J Christopher Fenno, Alexander H Rickard, Yvonne L Kapila
Metabolomics is used in systems biology to enhance the understanding of complex disease processes, such as cancer. Head and neck cancer (HNC) is an epithelial malignancy that arises in the upper aerodigestive tract and affects more than half a million people worldwide each year. Recently, significant effort has focused on integrating multiple "omics" technologies for oncological research. In particular, research has been focused on identifying tumor-specific metabolite profiles using different sample types (biological fluids, cells and tissues) and a variety of metabolomic platforms and technologies...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27875280/malnutrition-identified-by-the-academy-of-nutrition-and-dietetics-and-american-society-for-parenteral-and-enteral-nutrition-consensus-criteria-and-other-bedside-tools-is-highly-prevalent-in-a-sample-of-individuals-undergoing-treatment-for-head-and-neck-cancer
#8
Urvashi Mulasi, David M Vock, Adam J Kuchnia, Gautam Jha, Naomi Fujioka, Venkatesh Rudrapatna, Manish R Patel, Levi Teigen, Carrie P Earthman
BACKGROUND: Using the Academy of Nutrition and Dietetics and American Society for Parenteral and Enteral Nutrition (Academy/ASPEN) Consensus malnutrition definition, we estimated malnutrition prevalence in a sample of individuals with head and neck cancer (HNC) and compared it with the Patient-Generated Subjective Global Assessment (PG-SGA). We also investigated the utility of the 50-kHz phase angle (PA) and 200-kHz/5-kHz impedance ratio (IR) to identify malnutrition. MATERIALS AND METHODS: Nineteen individuals (18 males, 1 female) scheduled to undergo chemoradiotherapy were seen at 5 time points during and up to 3 months after treatment completion...
October 7, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27872524/human-papilloma-virus-in-oral-cavity-cancer-and-relation-to-change-in-quality-of-life-following-treatment-a-pilot-study-from-northern-india
#9
Abhishek Kumar Singh, Jitendra Kumar Kushwaha, Akshay Anand, Abhinav Arun Sonkar, Nuzhat Husain, Kirti Srivastava, Sudhir Singh
Human papilloma virus (HPV)-associated head and neck cancer (HNC) has generated significant amount of research interest in recent times with focus shifted to oral cavity squamous cell cancer (OCSCC) after oropharyngeal cancer. Due to high incidence of OCSCC and anecdotal reports on association of HPV infection from northern region of India, this study was conceived to investigate HPV infection and establish its association with lifestyle habits such as tobacco, alcohol consumption, oro-genital sex, number of sexual contacts, and change in quality of life posttreatment...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27865369/feasibility-of-using-head-and-neck-ct-imaging-to-assess-skeletal-muscle-mass-in-head-and-neck-cancer-patients
#10
Justin E Swartz, Ajit J Pothen, Inge Wegner, Ernst J Smid, Karin M A Swart, Remco de Bree, Loek P H Leenen, Wilko Grolman
OBJECTIVES: Patients with head and neck cancer (HNC) have a higher risk of malnutrition and sarcopenia, which is associated with adverse clinical outcome. As abdominal CT-imaging is often used to detect sarcopenia, such scans are rarely available in HNC patients, possibly explaining why no studies investigate the effect of sarcopenia in this population. We correlated skeletal muscle mass assessed on head and neck CT-scans with abdominal CT-imaging. METHODS: Head and neck, and abdominal CT-scans of trauma (n=51) and HNC-patients (n=52) were retrospectively analyzed...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27860386/raman-spectroscopy-can-discriminate-between-normal-dysplastic-and-cancerous-oral-mucosa-a-tissue-engineering-approach
#11
Salman A Mian, Ceyla Yorucu, Muhammad Saad Ullah, Ihtesham U Rehman, Helen E Colley
Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Squamous cell carcinoma, the primary cause of HNC, evolves from normal epithelium through dysplasia before invading the connective tissue to form a carcinoma. However, less than 18% of suspicious oral lesions progress to cancer, with diagnosis currently relying on histopathological evaluation, which is invasive and time consuming. A non-invasive, real-time, point-of-care method could overcome these problems and facilitate regular screening...
November 10, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27859893/psychosocial-effects-of-a-skin-camouflage-program-in-female-survivors-with-head-and-neck-cancer-a-randomized-controlled-trial
#12
Shu-Ching Chen, Bing-Shen Huang, Chien-Yu Lin, Kang-Hsing Fan, Joseph Tung-Chien Chang, Shu-Chen Wu, Yeur-Hur Lai
OBJECTIVE: The purpose of this study was to evaluate the effects of a skin camouflage program on disfigurement, self-esteem, social interaction, and body image in female head and neck cancer (HNC) survivors. METHODS: A prospective, repeated-measures, randomized controlled therapeutic intervention design was used. A total of 66 participants were randomly assigned to each group, with 32 in the experimental group and 34 in the control group. The experimental group received a 4-session skin camouflage program, and the control group received routine care...
November 15, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27857249/palliative-care-considerations-for-patients-with-head-and-neck-cancer-with-children-at-home
#13
Verna L Hendricks-Ferguson, Rebecca Ott
Adult patients diagnosed with head and neck cancer (HNC) who may have contact with children in the home setting are at risk of experiencing distress because of embarrassing and challenging oral symptoms often associated with an HNC diagnosis and the side effects of required treatments. This article features a case study involving a patient diagnosed with HNC and details how oncology nurses can provide patients with HNC and their caregivers with resources and support.
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27853984/fentanyl-pectin-nasal-spray-for-painful-mucositis-in-head-and-neck-cancers-during-intensity-modulated-radiation-therapy-with-or-without-chemotherapy
#14
R Mazzola, F Ricchetti, A Fiorentino, N Giaj-Levra, S Fersino, U Tebano, S Albanese, S Gori, F Alongi
PURPOSE: The aim of the current analysis was to evaluate the effectiveness and tolerability of rapid onset opioid in a cohort of head and neck cancer (HNC) patients affected by painful mucositis influencing swallowing function during RT ± ChT with definitive or adjuvant intent. METHODS: A retrospective analysis was conduct on HNC patients during RT ± ChT that received fentanyl pectin na sal spray (FPNS) for incidental BTP due to painful mucositis 13 min before the main meals...
November 16, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27848021/impact-of-compliance-on-dysphagia-rehabilitation-in-head-and-neck-cancer-patients-results-from-a-multi-center-clinical-trial
#15
Gintas P Krisciunas, Kerlly Castellano, Timothy M McCulloch, Cathy L Lazarus, Barbara R Pauloski, Tanya K Meyer, Darlene Graner, Douglas J Van Daele, Alice K Silbergleit, Lisa R Crujido, Denis Rybin, Gheorghe Doros, Tamar Kotz, Susan E Langmore
A 5-year, 16-site, randomized controlled trial enrolled 170 HNC survivors into active (estim + swallow exercise) or control (sham estim + swallowing exercise) arms. Primary analyses showed that estim did not enhance swallowing exercises. This secondary analysis determined if/how patient compliance impacted outcomes. A home program, performed 2 times/day, 6 days/week, for 12 weeks included stretches and 60 swallows paired with real or sham estim. Regular clinic visits ensured proper exercise execution, and detailed therapy checklists tracked patient compliance which was defined by mean number of sessions performed per week (0-12 times) over the 12-week intervention period...
November 16, 2016: Dysphagia
https://www.readbyqxmd.com/read/27844152/adherence-to-a-prophylactic-swallowing-therapy-program-during-chemo-radiotherapy-impact-of-service-delivery-model-and-patient-factors
#16
Laurelie R Wall, Elizabeth C Ward, Bena Cartmill, Anne J Hill, Sandro V Porceddu
Intensive, prophylactic swallowing therapy programs have been developed to improve dysphagia outcomes for patients with head/neck cancer (HNC) receiving (chemo)radiotherapy ([C]RT). Across studies, variable therapy adherence rates have been reported. Preliminary research suggests that service-delivery mode and demographic factors may influence adherence. This study examined patient adherence to a prophylactic swallowing therapy protocol across three service-delivery models: (1) clinician-directed face-to-face therapy, (2) technology-assisted therapy using the telepractice application, SwallowIT and (3) independent patient-directed therapy...
November 14, 2016: Dysphagia
https://www.readbyqxmd.com/read/27833352/adaptive-radiotherapy-for-head-neck-cancer
#17
Shrikant Balasaheb Mali
Changes in patient anatomy may occur either from a tumour volume, position or function of a specific organ at risk, or target volume, weight loss or a reduction in postoperative oedema, and may vary between patients. Adaptive radiotherapy aims to correct morphological variations by realizing one or more plans during the treatment course. Imaging is used to detect these variations, thereby deciding on a potential replanning. At present, adaptive radiotherapy for head neck cancer (HNC) mainly deals with treatment response, such as weight loss or tumor shrinkage...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27832971/metronomic-chemotherapy-in-head-and-neck-cancer
#18
Francesca De Felice, Ilaria Benevento, Angela Musella, Daniela Musio, Vincenzo Tombolini
Head neck cancer (HNC) is generally treated with a multimodality approach. Loco-regional-distant control is often worst, due to the advantage stage disease at diagnosis and the optimal treatment option remains an unresolved issue. Metronomic chemotherapy (MCHT) is an emerging therapeutic option in clinical oncology and it may prove useful in HNC patients.
November 8, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27822211/cd4-t-follicular-helper-and-iga-b-cell-numbers-in-gut-biopsies-from-hiv-infected-subjects-on-antiretroviral-therapy-are-similar-to-hiv-uninfected-individuals
#19
John Zaunders, Mark Danta, Michelle Bailey, Gerald Mak, Katherine Marks, Nabila Seddiki, Yin Xu, David J Templeton, David A Cooper, Mark A Boyd, Anthony D Kelleher, Kersten K Koelsch
BACKGROUND: Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation, and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4(+) T cells in gut-associated lymphoid tissue (GALT), but its impact on humoral immunity within GALT is unclear. Therefore, we studied CD4(+) subsets, including T follicular helper cells (Tfh), as well as resident B cells that have switched to IgA production, in gut biopsies, from HIV(+) subjects on suppressive ART compared to HIV-negative controls (HNC)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27815390/kv1-3-channels-mark-functionally-competent-cd8-tumor-infiltrating-lymphocytes-in-head-and-neck-cancer
#20
Ameet A Chimote, Peter Hajdu, Alexandros M Sfyris, Brittany N Gleich, Trisha Wise-Draper, Keith A Casper, Laura Conforti
Tumor infiltrating lymphocytes (TIL) are potent mediators of an anti-tumor response. However, their function is attenuated in solid tumors. CD8(+) T cell effector functions such as cytokine and granzyme production depend on cytoplasmic Ca(2+), which is controlled by ion channels. In particular, Kv1.3 channels regulate the membrane potential and Ca(2+) influx in human effector memory T (TEM) cells. In this study, we assessed the contribution of reduced Kv1.3 and Ca(2+) flux on TIL effector function in head and neck cancer (HNC)...
November 4, 2016: Cancer Research
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