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https://www.readbyqxmd.com/read/29779202/tumour-stage-and-gender-predict-recurrence-and-second-primary-malignancies-in-head-and-neck-cancer-a-multicentre-study-within-the-inhance-consortium
#1
Emanuele Leoncini, Vladimir Vukovic, Gabriella Cadoni, Luca Giraldi, Roberta Pastorino, Dario Arzani, Livia Petrelli, Victor Wünsch-Filho, Tatiana Natasha Toporcov, Raquel Ayub Moyses, Keitaro Matsuo, Cristina Bosetti, Carlo La Vecchia, Diego Serraino, Lorenzo Simonato, Franco Merletti, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, Stefania Boccia
Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium-Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52-67)...
May 19, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29773816/experimental-investigation-of-radiobiology-in-head-and-neck-cancer-cell-lines-as-a-function-of-hpv-status-by-mtt-assay
#2
Paul Reid, Puthenparampil Wilson, Yanrui Li, Loredana G Marcu, Alexander H Staudacher, Michael P Brown, Eva Bezak
Head and neck cancers (HNCs) are aggressive epithelial tumours frequently treated using radiation. HNC biology shows distinctions dependent on the oncologic involvement of the human papilloma virus (HPV). Clinically, HPV positive HNCs respond better to radiotherapy but few in vitro data demonstrate radiobiological differences explaining differences in clinical outcomes. This pilot study examined radiobiological responses to irradiation and subsequent regeneration in two HNC cell lines (HPV positive and negative)...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768689/hsp-enriched-properties-of-extracellular-vesicles-involve-survival-of-metastatic-oral-cancer-cells
#3
Kisho Ono, Takanori Eguchi, Chiharu Sogawa, Stuart K Calderwood, Junya Futagawa, Tomonari Kasai, Masaharu Seno, Kuniaki Okamoto, Akira Sasaki, Ken-Ichi Kozaki
Cancer cells often secrete extracellular vesicles (EVs) that carry heat shock proteins (HSPs) with roles in tumor progression. Oral squamous cell carcinoma (OSCC) belongs to head and neck cancers (HNC) whose lymph-node-metastases often lead to poor prognosis. We have examined the EV proteome of OSCC cells and found abundant secretion of HSP90-enriched EVs in lymph-node-metastatic OSCC cells. Double knockdown of HSP90α and HSP90β, using small interfering RNA significantly reduced the survival of the metastatic OSCC cells, although single knockdown of each HSP90 was ineffective...
May 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29761303/racial-differences-in-the-relationship-between-tobacco-alcohol-and-the-risk-of-head-and-neck-cancer-pooled-analysis-of-us-studies-in-the-inhance-consortium
#4
Kristin J Voltzke, Yuan-Chin Amy Lee, Zuo-Feng Zhang, Jose P Zevallos, Guo-Pei Yu, Deborah M Winn, Thomas L Vaughan, Erich M Sturgis, Elaine Smith, Stephen M Schwartz, Stimson Schantz, Joshua Muscat, Hal Morgenstern, Michael McClean, Guojun Li, Philip Lazarus, Karl Kelsey, Maura Gillison, Chu Chen, Paolo Boffetta, Mia Hashibe, Andrew F Olshan
There have been few published studies on differences between Blacks and Whites in the estimated effects of alcohol and tobacco use on the incidence of head and neck cancer (HNC) in the United States. Previous studies have been limited by small numbers of Blacks. Using pooled data from 13 US case-control studies of oral, pharyngeal, and laryngeal cancers in the International Head and Neck Cancer Epidemiology Consortium, this study comprised a large number of Black HNC cases (n = 975). Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for several tobacco and alcohol consumption characteristics...
May 14, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29756979/prevention-of-oral-mucositis-secondary-to-antineoplastic-treatments-in-head-and-neck-cancer-by-supplementation-with-oral-glutamine
#5
Jerónimo Pachón Ibáñez, José Luis Pereira Cunill, Guiovana Fernanda Osorio Gómez, Jose Antonio Irles Rocamora, Pilar Serrano Aguayo, Begoña Quintana Ángel, José Fuentes Pradera, Manuel Chaves Conde, María José Ortiz Gordillo, Pedro Pablo García Luna
OBJECTIVES: to evaluate the efficacy of glutamine in the prevention of the incidence of oral mucositis secondary to cancer therapies in patients with head and neck cancer (HNC). Secondary objectives were to know the incidence of odynophagia, interruptions of treatment and the requirements of analgesia and nasogastric tube. MATERIAL AND METHODS: prospective cohort study of patients with squamous cell carcinoma of HNC treated with radiotherapy ± concomitant chemotherapy...
February 27, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29756240/vitamin-d-intake-and-survival-and-recurrence-in-head-and-neck-cancer-patients
#6
Eva B Yokosawa, Anna E Arthur, Katie M Rentschler, Gregory T Wolf, Laura S Rozek, Alison M Mondul
OBJECTIVES/HYPOTHESIS: With an unacceptably low 5-year survival rate and few identified modifiable factors that affect head and neck cancer (HNC) outcomes, HNC survival remains an important public health problem. Vitamin D has been shown to be associated with immune reactivity and improved outcomes for some cancer sites, but findings are mixed, and few studies have examined vitamin D in relation to HNC. This study aimed to assess the association between vitamin D intake and survival outcomes in HNC patients...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29753503/novel-esophageal-reconstruction-technique-via-transmediastinal-route-from-posterior-to-anterior-mediastinum-after-esophagectomy
#7
Takushi Yasuda, Osamu Shiraishi, Mitsuru Iwama, Tomoki Makino, Hiroaki Kato, Yutaka Kimura
BACKGROUND: The incidence of metachronous esophageal squamous cell cancer (ESCC) after head and neck cancer (HNC) and in elderly patients has increased. Both elderly ESCC patients and ESCC patients after HNC surgery are at potential risk for dysphagia, and for the latter, surgery in the neck is difficult. An intrathoracic anastomosis that bypasses the cervical procedure is preferable to preserve swallowing function and reduce surgical risk. In gastrectomized patients, because the stomach cannot be used as a substitute, securing graft blood supply is critical, but microvascular anastomosis cannot be easily added in procedures for intrathoracic posterior mediastinal reconstruction...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29752155/a-retrospective-study-of-treatment-for-curative-synchronous-double-primary-cancers-of-the-head-and-neck-and-the-esophagus
#8
Tabito Okamoto, Chikatoshi Katada, Shouko Komori, Keishi Yamashita, Shunsuke Miyamoto, Koichi Kano, Yutomo Seino, Hiroshi Hosono, Hiroki Matsuba, Hiromitsu Moriya, Mitsuhiro Sugawara, Mizutomo Azuma, Hiromichi Ishiyama, Satoshi Tanabe, Kazushige Hayakawa, Wasaburo Koizumi, Makito Okamoto, Taku Yamashita
OBJECTIVE: Curative synchronous double primary cancers of the head and neck and the esophagus (CSC-HE) are frequently detected, but a standard treatment remains to be established. We studied the clinical course to explore appropriate treatment strategies. METHODS: We retrospectively studied consecutive 33 patients who had CSC-HE. The disease stage was classified into 4 groups: group A, early head and neck cancer (HNC) and early esophageal cancer (EC); group B, early HNC and advanced EC; group C, advanced HNC and early EC; and group D, advanced HNC and advanced EC...
May 8, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29747873/assessment-of-image-quality-of-a-radiotherapy-specific-hardware-solution-for-pet-mri-in-head-and-neck-cancer-patients
#9
René M Winter, Sara Leibfarth, Holger Schmidt, Kerstin Zwirner, David Mönnich, Stefan Welz, Nina F Schwenzer, Christian la Fougère, Konstantin Nikolaou, Sergios Gatidis, Daniel Zips, Daniela Thorwarth
BACKGROUND AND PURPOSE: Functional PET/MRI has great potential to improve radiotherapy planning (RTP). However, data integration requires imaging with radiotherapy-specific patient positioning. Here, we investigated the feasibility and image quality of radiotherapy-customized PET/MRI in head-and-neck cancer (HNC) patients using a dedicated hardware setup. MATERIAL AND METHODS: Ten HNC patients were examined with simultaneous PET/MRI before treatment, with radiotherapy and diagnostic scan setup, respectively...
May 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29747544/deep-hyperthermia-with-the-hypercollar-system-combined-with-irradiation-for-advanced-head-and-neck-carcinoma-a-feasibility-study
#10
G M Verduijn, E M de Wee, Z Rijnen, P Togni, J A U Hardillo, I Ten Hove, M Franckena, G C van Rhoon, M M Paulides
PURPOSE: Radiotherapy (RT) treatment of locally-advanced and recurrent head and neck carcinoma (HNC) results in disappointing outcomes. Combination of RT with cisplatin or cetuximab improves survival but the increased toxicity and patient's comorbidity warrant the need for a less-toxic radiosensitizer. Stimulated by several randomized studies demonstrating the radio-sensitizing effect of hyperthermia, we developed the HYPERcollar. Here, we report early experience and toxicity in patients with advanced HNC...
May 11, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29747023/assessment-of-dna-repair-susceptibility-genes-identified-by-whole-exome-sequencing-in-head-and-neck-cancer
#11
Raima Das, Sharbadeb Kundu, Shaheen Laskar, Yashmin Choudhury, Sankar Kumar Ghosh
Head and neck cancer (HNC), the sixth most common cancer globally, stands second in India. In Northeast (NE) India, it is the sixth most common cause of death in males and seventh in females. Prolonged tobacco and alcohol consumption constitute the major etiological factors for HNC development, which induce DNA damage. Therefore, DNA repair pathway is a crucial system in maintaining genomic integrity and preventing carcinogenesis. The present work was aimed to predict the consequence of significant germline variants of the DNA repair genes in disease predisposition...
April 26, 2018: DNA Repair
https://www.readbyqxmd.com/read/29746178/head-and-neck-squamous-cell-carcinoma-in-adolescents-and-young-adults-survivorship-patterns-and-disparities
#12
Sai D Challapalli, Matthew C Simpson, Eric Adjei Boakye, Jay S Pannu, Dary J Costa, Nosayaba Osazuwa-Peters
PURPOSE: Adolescent and young adult (AYA) head and neck cancer (HNC) patients require longer term follow-ups as they age; yet, little is known about factors associated with survivorship in this population. We aimed to describe nonclinical factors associated with HNC survivorship among AYAs. METHODS: In this retrospective cohort study, the Surveillance, Epidemiology and End Results 18 database from 2007 to 2014 was queried. Eligible cases were 15-39-year-old primary HNC patients with known cause of death (n = 1777)...
May 10, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29742280/quantitative-survival-impact-of-composite-treatment-delays-in-head-and-neck-cancer
#13
Allen S Ho, Sungjin Kim, Mourad Tighiouart, Alain Mita, Kevin S Scher, Joel B Epstein, Anna Laury, Ravi Prasad, Nabilah Ali, Chrysanta Patio, Jon Mallen St-Clair, Zachary S Zumsteg
BACKGROUND: Multidisciplinary management of head and neck cancer (HNC) must reconcile increasingly sophisticated subspecialty care with timeliness of care. Prior studies examined the individual effects of delays in diagnosis-to-treatment interval, postoperative interval, and radiation interval but did not consider them collectively. The objective of the current study was to investigate the combined impact of these interwoven intervals on patients with HNC. METHODS: Patients with HNC who underwent curative-intent surgery with radiation were identified in the National Cancer Database between 2004 and 2013...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29740440/targeting-head-and-neck-cancer-by-vaccination
#14
REVIEW
Chuan Wang, James Dickie, Ruhcha V Sutavani, Catherine Pointer, Gareth J Thomas, Natalia Savelyeva
Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29739713/volumetric-modulated-arc-therapy-of-head-and-neck-cancer-on-a-fast-rotating-o-ring-linac-plan-quality-and-delivery-time-comparison-with-a-c-arm-linac
#15
Steven Michiels, Kenneth Poels, Wouter Crijns, Laurence Delombaerde, Robin De Roover, Bianca Vanstraelen, Karin Haustermans, Sandra Nuyts, Tom Depuydt
BACKGROUND AND PURPOSE: Linac improvements in gantry speed, leaf speed and dose rate may increase the time-efficiency of volumetric modulated arc therapy (VMAT) delivery. The plan quality achievable with faster VMAT however remains to be investigated. In this study, a fast-rotating O-ring linac with fast-moving leaves is compared with a C-arm linac in terms of plan quality and delivery time for VMAT of head-and-neck cancer (HNC). MATERIAL AND METHODS: For 30 patients with HNC, treatment planning was performed using dual-arc (HA2) and triple-arc (HA3) VMAT on a Halcyon fast-rotating O-ring linac and using dual-arc VMAT on a TrueBeam C-arm linac (TB2)...
May 5, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29736121/analgesic-and-opioid-use-in-pain-associated-with-head-and-neck-radiation-therapy
#16
Sandeep Muzumder, S Nirmala, H U Avinash, Mg John Sebastian, Prashanth Bhat Kainthaje
Aim: The aim of the study is to find the incidence of analgesic and opioid use in pain associated in HNC patient undergoing radiation therapy. Background: Radiation therapy with concurrent chemotherapy has become the standard of care in head and neck cancer. Acute toxicity like mucositis and dysphagia has increased with aggressive therapy. Pain is an invariable accompaniment of oropharyngeal mucositis, which leads to decreased quality of life and treatment break...
April 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29728769/correction-to-patient-adherence-to-dysphagia-recommendations-a-systematic-review
#17
Brittany N Krekeler, Courtney K Broadfoot, Stephen Johnson, Nadine P Connor, Nicole Rogus-Pulia
The original version of this article unfortunately contains mistakes. The second sentence in the section "Results", under the heading "Study Design" was incorrect. It should read as: Two studies [24, 29] used a prospective cohort study design with a JAMA rating of 2. Four studies [17, 25, 27, 34] completed retrospective studies earning a JAMA score of 3. Four studies [26, 28, 30, 33] earned a JAMA quality rating score of 4 and used the following designs: case series [26, 28, 33], and pilot study [30]...
May 4, 2018: Dysphagia
https://www.readbyqxmd.com/read/29726363/dysphagia-treatment-for-patients-with-head-and-neck-cancer-undergoing-radiation-therapy-a-meta-analysis-review
#18
REVIEW
Elissa Greco, Tijana Simic, Jolie Ringash, George Tomlinson, Yoko Inamoto, Rosemary Martino
PURPOSE: Patients undergoing radiation therapy with or without chemotherapy (C/RT) for head and neck cancer (HNC) often develop dysphagia. Interventions from speech-language pathologists aim to maintain or improve swallow physiology and function. However, it is unclear which interventions provide the greatest benefit. We performed a systematic review to assess the benefit of exercise therapy on swallow physiology, function, and related quality of life (QOL). METHODS AND MATERIALS: We searched 7 electronic databases up to July 12, 2017, for all primary studies of any language or design that included the following: a behavioral swallowing intervention for patients with HNC treated with curative C/RT, a comparison group, and outcomes related to swallow physiology, function, and/or QOL...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29725850/the-association-with-xerostomia-from-sialadenitis-and-the-jaw-osteonecrosis-in-head-and-neck-cancer-population-a-nationwide-cohort-study
#19
Yi-Fang Huang, Chih-Hsin Muo, Chun-Hao Tsai, Shih-Ping Liu, Chung-Ta Chang
OBJECTIVES: Determine the association between sialadenitis and osteonecrosis of the jaw (ONJ) in head and neck cancer (HNC) patients with varying severity of sialadenitis, treatment modalities, and cancer locations. MATERIALS AND METHODS: A total of 40,168 HNC patients, including 1907 ONJ subjects and 7559 matched comparisons, were enrolled from a Longitudinal Health Insurance Database for Catastrophic Illness Patients of Taiwan between 2000 and 2006. The association with sialadenitis and ONJ was estimated by logic regression and presented as the odds ratio (OR) and 95% confidence intervals (CIs)...
May 3, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29725422/long-non-coding-rna-gastric-carcinoma-highly-expressed-transcript-1-promotes-cell-proliferation-and-invasion-in-human-head-and-neck-cancer
#20
Hui Liu, Yu Wu
Recent evidence indicates that the long non-coding RNA gastric carcinoma highly expressed transcript 1 (GHET1) is involved in the development and carcinogenesis of several tumor types; however, the exact roles of GHET1 and its underlying mechanisms in head and neck cancer (HNC) remain largely unknown. In the present study, the expression patterns of GHET1 in HNC were determined and its clinical significance was assessed. The expression level of GHET1 was significantly increased in HNC tissues, compared with paired adjacent normal tissues...
May 2018: Oncology Letters
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