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https://www.readbyqxmd.com/read/28524888/reducing-unplanned-admissions-focusing-on-hospital-admissions-and-emergency-department-visits-for-patients-with-head-and-neck-cancer-during-radiation-therapy%C3%A2
#1
Lauren Terzo, Mary Fleming, Alekhya Yechoor, Jayne Camporeale, Miriam Troxler, Elaine Roth, Xianming Tan, Michael Pignone, Lawrence Marks, Bhishamjit S Chera
BACKGROUND: Head and neck cancer (HNC) treatments cause severe toxicities, leading to high rates of emergency department (ED) visits and unplanned hospital admissions (UHAs). 
. OBJECTIVES: The study aimed to evaluate a quality improvement project to reduce ED visits and UHAs.
. METHODS: A weekly nurse/nurse practitioner-led symptom management clinic was created for patients with HNC receiving radiation therapy deemed at high risk for an ED visit or UHA...
June 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28522878/the-photodissociation-of-hcn-and-hnc-effects-on-the-hnc-hcn-abundance-ratio-in-the-interstellar-medium
#2
Alfredo Aguado, Octavio Roncero, Alexandre Zanchet, Marcelino Agúndez, José Cernicharo
The impact of the photodissociation of HCN and HNC isomers is analyzed in different astrophysical environments. For this purpose, the individual photodissociation cross section of HCN and HNC isomers have been calculated in the 7-13.6 eV photon energy range for a temperature of 10 K. These calculations are based on the ab initio calculation of three-dimensional adiabatic potential energy surfaces of the 21 lower electronic states. The cross sections are then obtained using a quantum wave packet calculation of the rotational transitions needed to simulate a rotational temperature of 10 K...
March 20, 2017: Astrophysical Journal
https://www.readbyqxmd.com/read/28516303/erratum-to-theoretical-study-of-the-h-hcn-%C3%A2-h-hnc-process
#3
Eberth Correa, Washington Barbosa da Silva, Patricia R P Barreto, Alessandra F Albernaz
No abstract text is available yet for this article.
June 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28515423/mir-520b-as-a-novel-molecular-target-for-suppressing-stemness-phenotype-of-head-neck-cancer-by-inhibiting-cd44
#4
Ya-Ching Lu, Ann-Joy Cheng, Li-Yu Lee, Guo-Rung You, Yan-Liang Li, Hsin-Ying Chen, Joseph T Chang
Cancer stem cells preferentially acquire the specific characteristics of stress tolerance and high mobility, allowing them to progress to a therapy-refractive state. To identify a critical molecule to regulate cancer stemness is indispensable to erratically cure cancer. In this study, we identified miR-520b as a novel molecular target to suppress head-neck cancer (HNC) with stemness phenotype. MiR-520b inhibited cellular migration and invasion via the mechanism of epithelial-mesenchymal transition. It also sensitized cells to therapeutic drug and irradiation...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28511189/the-role-of-audiometry-prior-to-high-dose-cisplatin-in-patients-with-head-and-neck-cancer
#5
Miguel Caballero, Paula Mackers, Oscar Reig, Elvira Buxo, Pilar Navarrete, Jose L Blanch, Juan J Grau
OBJECTIVES: To analyze the role of audiometry in considering change to a less ototoxic treatment in head and neck cancer (HNC) patients. METHODS: Consecutive patients prescribed high-dose cisplatin (100 mg/m2) between January 2013 and February 2015 were enrolled. Audiometry was performed at baseline and before cisplatin. Change to a less ototoxic agent or reduced cisplatin dose was considered with audiometric decreases >25 dB. RESULTS: A total of 103 patients were included; the median age of the patients was 59 years (range 18-75)...
May 17, 2017: Oncology
https://www.readbyqxmd.com/read/28507748/comparison-of-the-pull-and-introducer-percutaneous-endoscopic-gastrostomy-techniques-in-patients-with-head-and-neck-cancer
#6
Felipe A Retes, Fabio S Kawaguti, Marcelo S de Lima, Bruno da Costa Martins, Ricardo S Uemura, Gustavo A de Paulo, Caterina Mp Pennacchi, Carla Gusmon, Adriana Vs Ribeiro, Elisa R Baba, Sebastian N Geiger, Mauricio P Sorbello, Marco A Kulcsar, Ulysses Ribeiro, Fauze Maluf-Filho
BACKGROUND AND STUDY AIMS: Percutaneous endoscopic gastrostomy (PEG) in head and neck cancer (HNC) patients is associated with higher complication and mortality rates when compared to a general patient population. The pull technique is still the preferred technique worldwide but it has some limitations. The aim of this study is to compare the pull and introducer PEG techniques in patients with HNC. PATIENTS AND METHODS: This study is based on a retrospective analysis of a prospectively collected database of 309 patients with HNC who underwent PEG in the Cancer Institute of São Paulo...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28503348/emerging-trends-in-the-epidemiological-pattern-of-head-and-neck-cancers-in-lagos-nigeria
#7
O A Erinoso, E Okoturo, O M Gbotolorun, O A Effiom, N A Awolola, S S Soyemi, R T Oluwakuyide
BACKGROUND: Unfortunately, despite an increase in medical knowledge, survival rates of head and neck cancers (HNCs) have not been observed to improve greatly. This is true, especially in tumors located in obscure primary sites or late presentation. AIM: The purpose of this study is to assess the epidemiologic pattern of HNCs and to evaluate its emerging trends and patterns in Lagos state. SUBJECTS AND METHODS: A retrospective study was conducted from 2003 to 2013 that analyzed histologically diagnosed cases of HNC at the Pathology Departments of the two tertiary teaching hospitals in Lagos...
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28497009/false-positive-positron-emission-tomography-computed-tomography-scans-in-treated-head-and-neck-cancers
#8
Michael K Cheung, Shawn Y Ong, Uma Goyal, Betsy C Wertheim, Charles C Hsu, Sun K Yi
OBJECTIVE: Positron emission tomography/computed tomography (PET/CT) imaging for head and neck cancers (HNC) is commonly utilized for post-treatment assessment. Though PET/CT in this setting has been reported to have high negative predictive values (> 90%), positive predictive values have been reported at approximately 50%, leading to high rates of false positivity (FP) and troubling management decisions for both patient and practitioner. The objective of this study was to identify patient, disease, treatment and imaging factors that might be associated with a higher likelihood of FP on initial post-treatment PET/CT imaging for patients treated for HNC...
April 10, 2017: Curēus
https://www.readbyqxmd.com/read/28494850/efficacy-of-a-traditional-persian-medicine-preparation-for-radiation-induced-xerostomia-a-randomized-open-label-active-controlled-trial
#9
Ghazaleh Heydarirad, Hossein Rezaeizadeh, Rasool Choopani, Seyed Hamdollah Mosavat, Ahmad Ameri
BACKGROUND: Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers (HNC). However, conventional medicine lacks an effective treatment for radiation-induced xerostomia. OBJECTIVE: Synthesizing the traditional use of Alcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life (QOL) of HNC patients with radiation-induced xerostomia...
May 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28494483/the-cost-of-major-head-and-neck-cancer-surgery
#10
Rahul Jayakar, Jenny Choi, Craig MacKinnon, Swee Tan
AIM: This study quantified the cost of major head and neck cancer (HNC) surgery. METHODS: Consecutive patients undergoing major HNC surgery between July 2007 and June 2012 were identified from our head and neck database. Patient demographics, tumour type, site, stage and types of resection and reconstruction, length of stay and surgical complications occurring within six months of initial surgery were retrospectively analysed. The actual cost of initial surgical treatment and hospital income were calculated...
May 12, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28488375/factors-associated-with-healthcare-professional-s-rating-of-disfigurement-and-self-perceived-body-image-in-female-patients-with-head-and-neck-cancer
#11
S-C Chen, C-Y Huang, B-S Huang, C-Y Lin, K-H Fan, J T-C Chang, S-C Wu, Y-H Lai
The purpose of this study was to determine factors associated with self-perceived body image in female patients with head and neck cancer (HNC), and factors associated with healthcare professional's rating of disfigurement, as well as the correlation between patient and observer ratings. This cross-sectional study recruited 105 women with HNC at a large medical centre. Measures of facial disfigurement and body image, as well as demographic and clinical characteristics, were collected. Multivariate multiple linear regression modelling was used to identify factors associated with healthcare professional's rating of disfigurement and patient self-perceived body image...
May 9, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28476132/efficacy-and-safety-of-rebamipide-liquid-for-chemoradiotherapy-induced-oral-mucositis-in-patients-with-head-and-neck-cancer-a-multicenter-randomized-double-blind-placebo-controlled-parallel-group-phase-ii-study
#12
T Yokota, T Ogawa, S Takahashi, K Okami, T Fujii, K Tanaka, S Iwae, I Ota, T Ueda, N Monden, K Matsuura, H Kojima, S Ueda, K Sasaki, Y Fujimoto, Y Hasegawa, T Beppu, H Nishimori, S Hirano, Y Naka, Y Matsushima, M Fujii, M Tahara
BACKGROUND: Recent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in patients with oral cancer. This placebo-controlled randomized phase II study assessed the clinical benefit of rebamipide in reducing the incidence of severe chemoradiotherapy-induced oral mucositis in patients with head and neck cancer (HNC). METHODS: Patients aged 20-75 years with HNC who were scheduled to receive chemoradiotherapy were enrolled...
May 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28463432/temporal-patterns-of-patient-reported-trismus-and-associated-mouth-opening-distances-in-radiotherapy-for-head-and-neck-cancer-a-prospective-cohort-study
#13
Maria Thor, Caroline E Olsson, Jung Hun Oh, Johanna Hedström, Nina Pauli, Mia Johansson, Joseph O Deasy, Caterina Finizia
OBJECTIVES: To identify temporal patterns of patient-reported trismus during the first year post-radiotherapy, and to study their associations with maximal interincisal opening distances (MIOs). DESIGN: Single institution case series. SETTING: University hospital ENT clinic. PARTICIPANTS: One hundred ninety six subjects who received radiotherapy (RT) for head and neck cancer (HNC) with or without chemotherapy in 2007-2012 to total dose of 64...
April 30, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28460212/outcome-of-head-and-neck-cancer-patients-who-did-not-receive-curative-intent-treatment
#14
Deegesh Shah, Gary R Hoffman
PURPOSE: There exists a subgroup of patients with head and neck cancer (HNC) who neither warrant nor request curative-intent treatment and who progress to a terminal-care paradigm. The purpose of this study was to determine the frequency of and reasons for an HNC terminal-care referral and the time to and place of death for such patients. MATERIALS AND METHODS: The authors undertook a retrospective cohort study of all attendees with HNC who had undergone multidisciplinary team (MDT) assessment at the Calvary Mater Hospital (Newcastle, Australia) from January 2013 through December 2014...
April 6, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28459393/physical-and-emotional-well-being-and-support-in-newly-diagnosed-head-and-neck-cancer-patient-caregiver-dyads
#15
Katherine R Sterba, Jane Zapka, Kent E Armeson, Keisuke Shirai, Amy Buchanan, Terry A Day, Anthony J Alberg
The purpose of this study was to characterize physical and emotional well-being and support in newly diagnosed head and neck (HNC) patients and caregivers and identify sociodemographic, clinical and behavioral risk factors for compromised well-being in patients, caregivers and dyads.. Newly diagnosed HNC patients and their primary caregivers (N = 72 dyads) completed questionnaires before treatment assessing physical and mental well-being, depression, cancer worry and open-ended support questions. We identified factors associated with compromised well-being in patients, caregivers and dyads...
May 1, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28453887/self-management-strategies-used-by-head-and-neck-cancer-survivors-following-completion-of-primary-treatment-a-directed-content-analysis
#16
Simon Dunne, Orla Mooney, Laura Coffey, Linda Sharp, Aileen Timmons, Deirdre Desmond, Rachael Gooberman-Hill, Eleanor O'Sullivan, Ivan Keogh, Conrad Timon, Pamela Gallagher
OBJECTIVE: Head & Neck Cancer (HNC) survivors encounter unique challenges following treatment. This study aimed to identify self-management strategies that HNC survivors use to overcome these post-treatment challenges. METHODS: Twenty-seven individuals from four designated cancer centres in Ireland were interviewed about self-management strategies that helped them overcome challenges following HNC treatment. Interviews were audio-recorded, transcribed and analysed using directed content analysis...
April 28, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28451881/theoretical-study-of-the-h-hcn-%C3%A2-h-hcn-process
#17
Eberth Correa, Washington Barbosa da Silva, Patricia R P Barreto, Alessandra F Albernaz
We present a theoretical study on the detailed mechanism and kinetics of the H + HCN → H + HNC process. The potential energy surface was calculated at the complete basis set quantum chemical method, CBS-QB3. The vibrational frequencies and geometries for four isomers (H 2CN, cis-HCNH, trans-HCNH, CNH 2), and seven saddle points (TSn where n = 1 - 7) are very important and must be considered during the process of formation of the HNC in the reaction were calculated at the B3LYP/6-311G(2d,d,p) level, within CBS-QB3 method...
May 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28449704/rapidplan-head-and-neck-model-the-objectives-and-possible-clinical-benefit
#18
A Fogliata, G Reggiori, A Stravato, F Lobefalo, C Franzese, D Franceschini, S Tomatis, P Mancosu, M Scorsetti, L Cozzi
BACKGROUND: To evaluate a knowledge based planning model for RapidPlan (RP) generated for advanced head and neck cancer (HNC) patient treatments, as well its ability to possibly improve the clinical plan quality. The stability of the model was assessed also for a different beam geometry, different dose fractionation and different management of bilateral structures (parotids). METHODS: Dosimetric and geometric data from plans of 83 patients presenting HNC were selected for the model training...
April 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28449698/setup-errors-in-patients-with-head-neck-cancer-hnc-treated-using-the-intensity-modulated-radiation-therapy-imrt-technique-how-it-influences-the-customised-immobilisation-systems-patient-s-pain-and-anxiety
#19
Massimiliano Contesini, Monica Guberti, Roberta Saccani, Luca Braglia, Cinzia Iotti, Andrea Botti, Emilio Abbati, Marina Iemmi
BACKGROUND: In patients with head-neck cancer treated with IMRT, immobility of the upper part of the body during radiation is maintained by means of customised immobilisation devices. The main purpose of this study was to determine how the procedures for preparation of customised immobilisation systems and the patients characteristics influence the extent of setup errors. METHODS: A longitudinal, prospective study involving 29 patients treated with IMRT. Data were collected before CT simulation and during all the treatment sessions (528 setup errors analysed overall); the correlation with possible risk factors for setup errors was explored using a linear mixed model...
April 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28445287/prognostic-value-of-pretreatment-18f-fdg-pet-ct-for-nasopharyngeal-carcinoma-patients
#20
Yecai Huang, Mei Feng, Qiao He, Jun Yin, Peng Xu, Qinghua Jiang, Jinyi Lang
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a special subtype of head and neck cancer (HNC). At present, there are no highly specific prognostic markers to aid in tumor grading and guide patient treatment modalities for NPC. The prognostic value of pretreatment F-fluorodeoxyglucose positron emission tomography-computed tomography (F-PET-CT) in NPC patients is controversial and no consensus exists as to its predictive capability. METHODS: To analyze the predictive efficacy of F-PET-CT imaging in NPC patients, data from MEDLINE, EMBASE, the Cochrane library, CBM, CNKI, and VIP (inception to July 2016) were accessed...
April 2017: Medicine (Baltimore)
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