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Damage control surgery

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https://www.readbyqxmd.com/read/29775001/-expression-and-significance-of-serum-hepatocyte-growth-factor-and-myeloperoxidase-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#1
L B Liao, J M Zhai, G G Chen, Z E Ma, X B Yang, J G Zhang
Objective: The aim of this study is to explore the expression and significance of serum HGF and MPO in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) in adults. Method: Ninety-six cases of OSAHS patients diagnosed by PSG were divided into 3 groups: Heavy, medium and light according to the range of AHI; 32 cases of outpatients were healthy persons as the control group. The serum HGF and MPO were determined by ELISA; HGF and MPO were measured after comprehensive treat with CPAP in patients with severe OSAHS, and the correlation between HGF, MPO and PSG were analyzed...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29768493/remote-ischemic-preconditioning-stat3-dependently-ameliorates-pulmonary-ischemia-reperfusion-injury
#2
Nanfu Luo, Jin Liu, Yan Chen, Huan Li, Zhaoyang Hu, Geoffrey W Abbott
The lungs are highly susceptible to injury, including ischemia/reperfusion (I/R) injury. Pulmonary I/R injury can occur when correcting conditions such as primary pulmonary hypertension, and is also relatively common after lung transplantation or other cardiothoracic surgery. Methods to reduce pulmonary I/R injury are urgently needed to improve outcomes following procedures such as lung transplantation. Remote liver ischemic preconditioning (RLIPC) is an effective cardioprotective measure, reducing damage caused by subsequent cardiac I/R injury, but little is known about its potential role in pulmonary protection...
2018: PloS One
https://www.readbyqxmd.com/read/29761676/planned-re-laparotomy-in-a-non-trauma-setting-a-single-center-experience
#3
Yehuda Hershkovitz, Itamar Ashkenazi, Zahar Shapira, Oded Zmora, Igor Jeroukhimov
BACKGROUND: Damage control laparotomy (DCL) is the widely accepted procedure of choice in management of severely injured trauma patient. It has been implemented in non-trauma-related surgical pathology in the last decade. OBJECTIVES: To evaluate our experience with planned re-laparotomy (PRL) in non-trauma patients and compare it to other reports. METHODS: Charts of all patients admitted to Assaf Harofeh Medical Center who underwent PRL for non-trauma-related abdominal pathology during a 6 year period were reviewed...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29758052/decreased-circulating-t-regulatory-lymphocytes-in-obese-patients-undergoing-bariatric-surgery
#4
Claudia Agabiti-Rosei, Valentina Trapletti, Silvia Piantoni, Paolo Airò, Angela Tincani, Carolina De Ciuceis, Claudia Rossini, Francesco Mittempergher, Amin Titi, Nazario Portolani, Stefano Caletti, Maria Antonietta Coschignano, Enzo Porteri, Guido A M Tiberio, Paola Pileri, Leonardo Solaini, Rajesh Kumar, Silvia Ministrini, Enrico Agabiti Rosei, Damiano Rizzoni
OBJECTIVE: It has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, and that circulating T effector lymphocytes may be increased in hypertension. In particular, Th1 and Th 17 lymphocytes may contribute to the progression of hypertension and microvascular damage while T-regulatory (Treg) lymphocytes seem to be protective in this regard. However, no data is available about patients with severe obesity, in which pronounced microvascular alterations were observed...
2018: PloS One
https://www.readbyqxmd.com/read/29757195/resolvins-in-inflammation-emergence-of-the-pro-resolving-superfamily-of-mediators
#5
Charles N Serhan, Bruce D Levy
Countless times each day, the acute inflammatory response protects us from invading microbes, injuries, and insults from within, as in surgery-induced tissue injury. These challenges go unnoticed because they are self-limited and naturally resolve without progressing to chronic inflammation. Peripheral blood markers of inflammation are present in many common diseases, including inflammatory bowel disease, cardiovascular disease, neurodegenerative disease, and cancer. While acute inflammation is protective, excessive swarming of neutrophils amplifies collateral tissue damage and inflammation...
May 14, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29756637/withdrawal-of-immunosuppressant-or-biologic-therapy-for-patients-with-quiescent-crohn-s-disease
#6
REVIEW
Ray K Boyapati, Joana Torres, Carolina Palmela, Claire E Parker, Orli M Silverberg, Sonam D Upadhyaya, Tran M Nguyen, Jean-Frédéric Colombel
BACKGROUND: Crohn's disease (CD) is a chronic, relapsing and remitting disease of the gastrointestinal tract that can cause significant morbidity and disability. Current treatment guidelines recommend early intervention with immunosuppressant or biological therapy in high-risk patients with a severe disease phenotype at presentation. The feasibility of therapeutic de-escalation once remission is achieved is a commonly encountered question in clinical practice, driven by patient and clinician concerns regarding safety, adverse events, cost and national regulations...
May 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29755553/neuroprotective-effect-of-paroxetine-on-memory-deficit-induced-by-cerebral-ischemia-after-transient-bilateral-occlusion-of-common-carotid-arteries-in-rat
#7
Yazdan Naderi, Siavash Parvardeh, Taraneh Moini Zanjani, Masoumeh Sabetkasaei
Memory deficit is the most visible symptom of cerebral ischemia. The hippocampus is sensitive against cerebral ischemia. Oxidative stress and inflammation are involved in the pathological process after cerebral ischemic injury. Paroxetine has anti-oxidative and anti-inflammatory effects. In this study, the effect of paroxetine on memory deficit after cerebral ischemia was investigated. Cerebral ischemia/reperfusion (I/R) injury model was established using the bilateral occlusion of common carotid artery method...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29752770/one-carbon-cycle-support-rescues-sperm-damages-in-experimentally-induced-varicocele-in-rats
#8
Parisa Mohammadi, Hassan Hassani Bafrani, Marziyeh Tavalaee, Maurizio Dattilo, Mohammad Hossein Nasr-Esfahani
OBJECTIVES: To demonstrate that micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage following surgical varicocele in rats and that this effect is achieved without suffering a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS: Surgical varicocele was induced in adult male Wistar rats and resulted in significant damage to testis and sperm cells measured 2 and 4 months post-surgery...
May 11, 2018: BJU International
https://www.readbyqxmd.com/read/29752333/the-endocrinology-of-male-breast-cancer
#9
REVIEW
Ian S Fentiman
Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E2 ) levels from hepatic conversion of androgen...
June 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29747017/a-novel-association-between-intrathecal-drug-administration-and-arachnoiditis-ossificans
#10
Max Ward, Antonios Mammis, Maureen T Barry, Robert F Heary
We present a case of delayed progression of adhesive arachnoiditis to arachnoiditis ossificans (AO) in a patient being treated with a high dose polypharmaceutical intrathecal regimen. The patient is a 39-year-old Caucasian male who was implanted with an intrathecal pump in 2006 to control severe low back pain and administered intrathecal pain medication for a period of 10 years. In 2016, he developed new onset radicular pain and worsened sensation in his lower extremities. A CT scan of the lumbar spine at that time demonstrated profound calcification of the arachnoid consistent with a diagnosis of AO...
May 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29742889/intraoperative-neurophysiological-monitoring-a-review-of-techniques-used-for-brain-tumor-surgery-in-children
#11
REVIEW
Keewon Kim, Charles Cho, Moon-Suk Bang, Hyung-Ik Shin, Ji-Hoon Phi, Seung-Ki Kim
Intraoperative monitoring (IOM) utilizes electrophysiological techniques as a surrogate test and evaluation of nervous function while a patient is under general anesthesia. They are increasingly used for procedures, both surgical and endovascular, to avoid injury during an operation, examine neurological tissue to guide the surgery, or to test electrophysiological function to allow for more complete resection or corrections. The application of IOM during pediatric brain tumor resections encompasses a unique set of technical issues...
May 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29741715/forward-surgical-team-experience-fste-is-associated-with-increased-confidence-with-combat-surgeon-trauma-skills
#12
D Joshua Mancini, Brian P Smith, Travis M Polk, C William Schwab
Introduction: Little is known regarding the confidence of military surgeons prior to combat zone deployment. Military surgeons are frequently deployed without peers experienced in combat surgery. We hypothesized that forward surgical team experience (FSTE) increases surgeon confidence with critical skill sets. Methods: We conducted a national survey of military affiliated personnel. We used a novel survey instrument that was piloted and validated by experienced military surgeons to collect demographics, education, practice patterns, and confidence parameters for trauma and surgical critical care skills...
May 8, 2018: Military Medicine
https://www.readbyqxmd.com/read/29737234/biofabricated-structures-reconstruct-functional-urinary-bladders-in-radiation-injured-rat-bladders
#13
Tetsuya Imamura, Mitsuru Shimamura, Teruyuki Ogawa, Tomonori Minagawa, Takashi Nagai, Sudha Silwal Gautam, Osamu Ishizuka
The ability to repair damaged urinary bladders through the application of bone marrow-derived cells is in the earliest stages of development. We investigated the application of bone marrow-derived cells to repair radiation-injured bladders. We used a three-dimensional (3D) bioprinting robot system to biofabricate bone marrow-derived cell structures. We then determined if the biofabricated structures could restore the tissues and functions of radiation-injured bladders. The bladders of female 10-week-old Sprague-Dawley (SD) rats were irradiated with 2-Gy once a week for 5 weeks...
May 8, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29734915/metacarpal-locked-intramedullary-nail-surgical-technique-and-preliminary-outcome-report
#14
Sunyarn Niempoog, Thanapong Waitayawinyu, Chinnakart Boonyasirikool
In surgically indicated metacarpal fractures, the ideal fixation should provide an ample stability for early rehabilitation. Damage to surrounding tissue should be minimized as well, to prevent stiffness which determine the outcomes. We have created the metacarpal locked intramedullary nail (MCLN) that allows immediate motion even in unstable fractures. This preliminary report is objected to demonstrate the surgical technique and outcomes of novel metacarpal fixation. Three surgical indicated metacarpal fractures were treated by MCLN...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29731691/analysis-of-selected-pro-and-anti-inflammatory-cytokines-in-patients-with-multiple-injuries-in-the-early-period-after-trauma
#15
Katarzyna Gołąbek-Dropiewska, Justyna Pawłowska, Jacek Witkowski, Jerzy Lasek, Wojciech Marks, Mariusz Stasiak, Dawid Jaskólski, Aleksandra Kawecka, Piotr Łuczkiewicz, Bogusław Baczkowski
Introduction: Severe trauma causes damage to the protective barriers of the organism, and thus activates immunological reaction. Among substances secreted during this process pro-inflammatory cytokines are of high importance. The aim of the study: Severe trauma causing multiple injuries is more likely to lead to particularly intensive inflammatory reaction, which can sometimes lead to serious complications, even life-threatening. The aim of the study is to determine those parameters which may serve as predictors of infectious complications and to enable estimation of the patient's immunological status before the decision to introduce elective procedures...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29727865/prospective-study-on-several-urinary-biomarkers-as-indicators-of-renal-damage-in-children-with-cakut
#16
Fabio Bartoli, Valentina Pastore, Isabella Calè, Gabriella Aceto, Vittoria Campanella, Carla Lasalandra, Simona Magaldi, Francesco Niglio, Angela Basile, Raffaella Cocomazzi
PURPOSE:  The aim of the study was to investigate urinary levels of monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), β-2-microglobulin (β2M), and FAS-ligand (FAS-L) in children with congenital anomalies of kidney and urinary tract (CAKUT) disease at risk of developing glomerular hyperfiltration syndrome. For this reason, we selected patients with multicystic kidney, renal agenesia and renal hypodysplasia, or underwent single nephrectomy. MATERIALS AND METHODS:  This prospective, multicentric study was conducted in collaboration between the Pediatric Surgery Unit in Foggia and the Pediatric Nephrology Unit in Bari, Italy...
May 4, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29725381/soleus-muscle-h-reflex-monitoring-in-endoscopic-surgery-under-general-anesthesia-percutaneous-interlaminar-approach
#17
Huixue Wang, Yingji Gao, Lixin Ji, Wanshan Bai
The clinical value of soleus muscle H-reflex monitoring in general anesthesia percutaneous interlaminar approach was investigated. A total of 80 cases with unilateral L5-S1 disc herniation between January 2015 and October 2016 were randomly divided into control group (without soleus muscle H-reflex monitoring, n=40) and observation group (with soleus muscle H-reflex monitoring, n=40). Results showed that the operation time of the observation group was shorter than that of the control group (P<0.05), and the blood loss during the operation was less than that of the control group (P<0...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29724533/targeting-phosphodiesterase-5-by-vardenafil-improves-vascular-graft-function
#18
Gábor Veres, Martin Hagenhoff, Harald Schmidt, Tamás Radovits, Sivakkanan Loganathan, Yang Bai, Sevil Korkmaz-Icöz, Paige Brlecic, Alex Ali Sayour, Matthias Karck, Gábor Szabó
OBJECTIVES: Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis that the phosphodiesterase-5 inhibitor vardenafil would protect vascular grafts against IR injury by upregulating the nitric oxide-cGMP pathway in the vessel wall of the bypass graft was investigated...
May 1, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29717788/assessment-of-liver-ischemia-reperfusion-injury-in-mice-using-hepatic-t-2-mapping-comparison-with-histopathology
#19
Katja Hueper, Hannah Lang, Björn Hartleben, Marcel Gutberlet, Thorsten Derlin, Tobias Getzin, Rongjun Chen, Hassan Abou-Rebyeh, Frank Lehner, Martin Meier, Hermann Haller, Frank Wacker, Song Rong, Faikah Gueler
BACKGROUND: Liver ischemia reperfusion injury (IRI) occurs during liver surgery or transplantation resulting in an inflammatory response, tissue damage, and functional impairment of the organ. PURPOSE: To assess the feasibility of T2 mapping for noninvasive quantification of liver edema after partial liver IRI in mice. STUDY TYPE: Prospective, experimental study. ANIMAL MODEL: Partial liver IRI was induced in C57BL/6-mice by transient clamping of the left lateral and median liver lobes for 35 (n = 8), 45 (n = 6), 60 (n = 17), or 90 minutes (n = 5)...
May 2, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29717373/transpapillary-endopancreatic-surgery-decompression-of-duct-system-and-comparison-of-greenlight-laser-with-monopolar-electrosurgical-device-in-ex-vivo-and-in-vivo-animal-models
#20
Philip C Müller, Daniel C Steinemann, Lukas Chinczewski, Gencay Hatiboglu, Felix Nickel, Kaspar Z'graggen, Beat P Müller-Stich
BACKGROUND: Endopancreatic surgery (EPS) is an experimental minimally invasive technique for resection of pancreatic tissue from inside the pancreatic duct, accessed via the duodenum and papilla. It is proposed as an alternative to duodenum-preserving pancreatic head resection in benign diseases such as chronic pancreatitis (CP). This study evaluated the use of EPS for resection of pancreatic duct stenoses. Moreover, greenlight laser (GLL) and monopolar electrosurgical device (MES) were compared as resection tools for EPS...
May 1, 2018: Surgical Endoscopy
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