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https://www.readbyqxmd.com/read/28944863/microrna%C3%A2-509-acts-as-a-tumor-suppressor-in-tongue-squamous-cell-carcinoma-by-targeting-epidermal-growth-factor-receptor
#1
Chao Hou, Yan Dong, Fenghe Zhang, Bo Du
Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral carcinoma, and is characterized by high metastatic and growth capabilities. Previous studies have demonstrated that aberrantly expressed cancer‑associated microRNAs (miRs) may be associated with tumorigenesis and tumor development in various types of cancer, including TSCC. miR‑509 has been identified as a critical regulator in tumorigenesis and tumor development, via its tumor‑suppressing actions in several types of human cancer...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28943954/epigallocatechin-3-gallate-suppresses-cell-proliferation-and-promotes-apoptosis-in-ec9706-and-eca109-esophageal-carcinoma-cells
#2
Liang Liu, Jing Zuo, Guangda Wang
Epigallocatechin-3-gallate (EGCG) is a component of green tea with anticancer effects that have been demonstrated in multiple types of cancer, but few reports exist concerning its effect in esophageal squamous cell carcinoma cells. The present study investigated apoptosis induced by EGCG treatment and the underlying molecular mechanisms in Eca109 and Ec9706 human esophageal squamous cell carcinoma cells. The apoptosis rate following treatment with various concentration of EGCG for 24 h was detected by flow cytometry...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943930/downregulation-of-cytochrome-c-oxidase-1-induced-radioresistance-in-esophageal-squamous-cell-carcinoma
#3
Tomoko Takesue, Hirofumi Kawakubo, Tetsu Hayashida, Mai Tsutsui, Kazuhiro Miyao, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Hiroya Takeuchi, Yuko Kitagawa
Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another location in the genome at random. By inserting the cytomegalovirus promotor as a transcriptional activator in the transposon, the following gene in the new location becomes overexpressed and the gene located at the transposon insertion site is downregulated...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943917/mechanisms-of-cxcr7-induction-in-malignant-melanoma-development
#4
Xiao-Jing Li, Pai Liu, Wei-Wei Tian, Zhi-Feng Li, Bao-Guo Liu, Jian-Fang Sun
Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C-X-C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. The present study sought to investigate the effects of CXCR7 on MM development. First, CXCR7 expression levels were assessed in the skin tumor tissue of patients with MM. Then, CXCR7 small hairpin RNA was used in M14 melanoma cells in a Transwell culture model and in a transplanted mouse model to test the effects of CXCR7...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943462/dna-polymeric-films-as-a-support-for-cell-growth-as-a-new-material-for-regenerative-medicine-compatibility-and-applicability
#5
Cristiano Ceron Jayme, Leonardo Barcelos de Paula, Nayara Rezende, Italo Rodrigo Calori, Leonardo Pereira Franchi, Antonio Claudio Tedesco
DNA polymeric films (DNA-PFs) are a promising drug delivery system (DDS) in modern medicine. In this study, we evaluated the growth behavior of oral squamous cell carcinoma (OSCC) cells on DNA-PFs. The morphological, biochemical, and cytometric features of OSCC cell adhesion on DNA-PFs were also assessed. An initial, temporary alteration in cell morphology was observed at early time points owing to the inhibition of cell attachment to the film, which then returned to a normal morphological state at later time points...
September 21, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28943128/patterns-of-care-and-impact-of-brachytherapy-boost-utilization-for-squamous-cell-carcinoma-of-the-base-of-tongue-in-a-large-national-cohort
#6
Anna Lee, Babak Givi, S Peter Wu, Moses M Tam, Naamit K Gerber, Kenneth S Hu, Peter Han, David Schreiber
PURPOSE: The National Cancer Data Base was analyzed to evaluate the patterns of care and impact of brachytherapy (BT) boost on overall survival (OS) for patients with squamous cell carcinoma of the base of tongue. METHODS AND MATERIALS: Patients with nonmetastatic squamous cell carcinoma of the base of tongue between 2004 and 2012 who received concurrent external beam radiation therapy (EBRT) and chemotherapy with or without BT boost in the definitive setting were queried...
September 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28942182/mutational-signatures-efficiently-identify-different-mutational-processes-underlying-cancers-with-similar-somatic-mutation-spectra
#7
Nan Zhou, Yuan Yuan, Xin Long, Chuanfang Wu, Jinku Bao
Compared to analyzing mutations with conventional spectra, deciphering mutational signatures provides much greater resolution of biological processes that generate somatic mutations during cancer development. Previous studies of bladder urothelial cancer (BLCA) and cervical squamous cell carcinoma (CESC) mutational signatures failed to uncover different mutational processes underlying the two cancers, which diminishes the capability of mutational signature to differentiate between the two cancers. In this study, we deciphered and compared the mutational signatures of BLCA and CESC...
July 19, 2017: Mutation Research
https://www.readbyqxmd.com/read/28942036/polysaccharides-isolated-from-hedyotis-diffusa-inhibits-the-aggressive-phenotypes-of-laryngeal-squamous-carcinoma-cells-via-inhibition-of-bcl-2-mmp-2-and-%C3%AE-pa
#8
Caiqin Wu, Huanan Luo, Weijun Ma, Xiaoyong Ren, Chuangxin Lu, Ni Li, Zhenghui Wang
Hedyotis diffusa, a traditional Chinese herbal medicine, possesses anti-cancer, anti-oxidative, and anti-inflammatory effects. The aim of this study is to explore the anti-tumor potential of Hedyotis diffusa polysaccharides (HDP) in human larynx squamous carcinoma. High performance size-exclusion chromatography analysis indicated the homogeneous nature of HDP. Total carbohydrate content in HDP was 97.3%, without contamination of protein and nucleic acid. HDP suppressed the proliferation of Hep2 human larynx squamous carcinoma cells in a time- and dose-dependent manner...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28941722/upregulation-of-uc-189-in-patients-with-esophageal-squamous-cell-carcinoma-and-its-clinicopathologic-value
#9
Yan Guo, Chenghai Wang, Xin Miao, Siyu Chen, Yu Qian, Guoli Li, Ying Jiang
Ultraconserved elements (UCEs) encoding noncoding RNAs serve as important regulators in cancer biology. Until now, the role of the UCE uc.189 in human cancers remains undefined and the clinical significance of uc.189 in esophageal cancers remains unknown. This study was to identify the prognostic value of uc.189 expression in esophageal squamous cell carcinomas (ESCC). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of uc.189 in matched cancerous tissues and adjacent noncancerous tissues from 152 patients with ESCC...
September 7, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28941320/characteristics-of-the-local-recurrence-pattern-after-curative-resection-and-values-in-target-region-delineation-in-postoperative-radiotherapy-for-lower-thoracic-esophageal-squamous-cell-cancer
#10
Jun Liu, Xuwei Cai, Qi Liu, Hongxuan Li, Yan Cheng, Xiaolong Fu
BACKGROUND: The aim of this study was to investigate the patterns and influencing factors of local-regional recurrence of lower thoracic esophageal squamous cell carcinoma (TESCC) after curative resection and to delineate the clinical target volume (CTV) of postoperative radiotherapy (PORT). METHODS: From January 2009 to December 2013, the clinical data of patients who experienced local-regional recurrence after curative esophagectomy were collected and analyzed to determine local-regional recurrence patterns and to evaluate whether a proposed T-shaped PORT CTV could cover regions of local-regional failure...
September 23, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28941263/epidermodysplasia-verruciformis-three-case-reports-and-a-brief-review
#11
Sharma Shruti, Fouzia Siraj, Avninder Singh, V Ramesh
Epidermodyplasia verruciformis (EV) is a rare heritable disease that is characterized by an increased susceptibility to infection with specific human papillomavirus (HPV) types due to a defect in cell-mediated immune response to HPV infection. Widespread infection with HPV is responsible for the development of wart-like lesions and pityriasis versicolor-like spots. These individuals have a lifelong risk of developing cutaneous malignancies, especially Bowen's disease and squamous cell carcinoma, mainly in sun-exposed parts...
September 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28941018/role-of-non-coding-rnas-in-head-and-neck-squamous-cell-carcinoma-a-narrative-review
#12
REVIEW
M K Sannigrahi, Rajni Sharma, Naresh K Panda, Madhu Khullar
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non-coding RNA (ncRNA) might play critical role in regulating different types of cancer. MicroRNAs (miRs) are short ncRNAs (20-25 nucleotides), responsible for post-transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor-suppressors miRs. Long non-coding RNAs (lncRNAs) are heterogenous group of ncRNAs more than 200 nucleotides long, can act in cis and/or in trans, and, have been also implicated in carcinogenesis...
September 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28940738/macrophages-and-prognosis-of-oral-squamous-cell-carcinoma-a-systematic-review
#13
REVIEW
Alessandro Menna Alves, Leonardo Francisco Diel, Marcelo Lazzaron Lamers
Oral Squamous Cell Carcinoma (OSCC) presents a tumor microenvironment rich in inflammatory cells. Depending on the stimulus, macrophages can polarize in M1 or M2 profile, where M1 act as proinflammatory and antitumor and M2 is anti-inflammatory and shows protumor activity. Several studies have shown that macrophages are important to the prognosis of patients in different types of cancer. Our aim was to conduct a systematic review to evaluate the role of macrophages in the prognosis of OSCC patients. A search in the Pubmed, Scopus and ISI Web of Knowledge database was performed and it was included only studies that evaluated the importance of macrophages in the prognosis of OSCC patients...
September 21, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28940455/probability-of-cancer-in-high-risk-patients-predicted-by-the-protein-based-lung-cancer-biomarker-panel-in-china-lcbp-study
#14
Dawei Yang, Xiaoju Zhang, Charles A Powell, Jun Ni, Bin Wang, Jianya Zhang, Yafei Zhang, Lijie Wang, Zhihong Xu, Li Zhang, Guoming Wu, Yong Song, Wenhua Tian, Jia-An Hu, Yong Zhang, Jie Hu, Qunying Hong, Yuanlin Song, Jian Zhou, Chunxue Bai
BACKGROUND: The authors built a model for lung cancer diagnosis previously based on the blood biomarkers progastrin-releasing peptide (ProGRP), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), and cytokeratin 19 fragment (CYFRA21-1). In the current study, they examined whether modification of the model to include relevant clinical information, risk factors, and low-dose chest computed tomography screening would improve the performance of the biomarker panel in large cohorts of Chinese adults...
September 20, 2017: Cancer
https://www.readbyqxmd.com/read/28940194/a-new-model-system-identifies-egfr-her2-and-her2-her3-heterodimers-as-potent-inducers-of-oesophageal-epithelial-cell-invasion
#15
Christiane Daniela Fichter, Camilla Maria Przypadlo, Achim Buck, Nicola Herbener, Bianca Riedel, Luisa Schäfer, Hiroshi Nakagawa, Axel Walch, Thomas Reinheckel, Martin Werner, Silke Lassmann
Oesophageal squamous cell carcinomas and oesophageal adenocarcinomas display distinct patterns of ErbB expression and dimers. The functional effects of specific ErbB homo- or heterodimers on oesophageal (cancer) cell behaviour, particularly invasion of early carcinogenesis remains unknown. Here, a new cellular model system for controlled activation of EGFR or HER2 and EGFR/HER2 or HER2/HER3 homo- and heterodimers was studied in non-neoplastic squamous oesophageal epithelial Het-1A cells. EGFR, HER2 and HER3 intracellular domains (ICDs) were fused to dimerization domains (DmrA / DmrA and DmrC), and transduced into Het-1A cells lacking ErbB expression...
September 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28939985/l1cam-drives-oncogenicity-in-esophageal-squamous-cell-carcinoma-by-stimulation-of-ezrin-transcription
#16
Jin-Cheng Guo, Yang-Min Xie, Li-Qiang Ran, Hui-Hui Cao, Chun Sun, Jian-Yi Wu, Zhi-Yong Wu, Lian-Di Liao, Wei-Jiang Zhao, Wang-Kai Fang, En-Min Li, Li-Yan Xu, Melitta Schachner, Jian-Jun Xie
L1 cell adhesion molecule (L1CAM) is highly expressed in various types of human cancers, displaying yet unknown molecular mechanisms underlying their oncogenic potential. Here, we found that L1CAM expression was significantly increased in esophageal squamous cell carcinoma (ESCC; n = 157) lesions compared with non-cancerous tissues. High tumorous L1CAM expression significantly correlated with reduced overall survival. Experimentally, L1CAM knockdown led to decreased cell growth, migration, and invasiveness in vitro, whereas overexpression of L1CAM showed the opposite effect...
September 22, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28939847/dual-mab-her-family-blockade-in-head-and-neck-cancer-human-cell-lines-combined-with-photon-therapy
#17
Jean-Baptiste Guy, Benoîte Méry, Edouard Ollier, Sophie Espenel, Alexis Vallard, Anne-Sophie Wozny, Stéphanie Simonet, Alexandra Lauret, Priscillia Battiston-Montagne, Dominique Ardail, Gersende Alphonse, Chloé Rancoule, Claire Rodriguez-Lafrasse, Nicolas Magné
Head and neck cancer stem cells (CSCs) are highly resistant to treatment. When EGFR is overexpressed in head and neck squamous cell carcinoma (HNSCC), HER2 and HER3 are also expressed. The aim of the present study was to investigate the effect of HER1/2/3 blockade through a combination of cetuximab and pertuzumab, with or without photon irradiation, on the proliferation and migration/invasion capabilities of an HNSCC chemo- and radioresistant human cell line (SQ20B) and its corresponding stem cell subpopulation...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28939763/a-novel-long-noncoding-rna-linc00460-upregulated-by-cbp-p300-promotes-carcinogenesis-in-esophageal-squamous-cell-carcinoma
#18
Yan Liang, Yuanyuan Wu, Xuedan Chen, Shixin Zhang, Kai Wang, Xingying Guan, Kang Yang, Juan Li, Yun Bai
Esophageal cancer is one of the leading causes of cancer related mortality because of poor prognosis. Long noncoding RNAs (lncRNAs) have been gradually demonstrated to play critical roles in cancer development. We indentified a novel long noncoding RNA named linc00460 by microarray analysis using esophageal squamous cell carcinoma (ESCC) clinical samples, which has not been studied before. Our research indicated that linc00460 was overexpressed in the majority of tumor tissues and ESCC cell lines. Linc00460 expression was positively correlated with ESCC TNM stage, lymph node metastasis and predicted poor prognosis...
September 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28939082/epigenetic-therapy-regulates-the-expression-of-aldh1-and-immunologic-response-relevance-to-the-prognosis-of-oral-cancer
#19
Ming-Shao Tsai, Wen-Cheng Chen, Chia-Hsuan Lai, Yu-Yen Chen, Miao-Fen Chen
OBJECTIVES: Aldehyde dehydrogenase 1 (ALDH1) is associated with tumorigenesis, and shown to identify cancer stem cells (CSC)-like cells. We aimed to investigate the significance of ALDH1 in oral squamous cell carcinoma (OSCC) and its correlation with DNMT3b and immune evasion in the present study. METHODS: We retrospectively analyzed the clinical outcomes of OSCC patients and examined its correlation with the levels of ALDH1 in tumors and circulating myeloid-derived suppressor cells (MDSCs) in the peripheral blood...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28939080/prevalence-of-high-risk-human-papillomavirus-infection-and-cancer-gene-mutations-in-nonmalignant-tonsils
#20
Taru Ilmarinen, Pauliina Munne, Jaana Hagström, Caj Haglund, Eeva Auvinen, Elina I Virtanen, Annick Haesevoets, Ernst J M Speel, Leena-Maija Aaltonen
OBJECTIVES: To analyze the prevalence of high-risk HPV (human papillomavirus) and genetic alterations in nonmalignant tonsils. METHODS: We collected benign fresh tonsillar tissue specimens from 477 patients undergoing tonsillectomy because of chronic tonsillitis or tonsillar hypertrophy in 2012 (Group A, n=237) and in 2015 (Group B, n=240). Luminex xMAP technique served to detect E6/E7 DNA from 16 different high-risk HPV types. Tonsillar DNA and peripheral blood leukocyte DNA from the infected individuals were analyzed using Nimblegen SeqCap EZ Comprehensive Cancer Design panel...
October 2017: Oral Oncology
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