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Highly sensitive troponin

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https://www.readbyqxmd.com/read/29793175/apolipoprotein-ciii-and-n-terminal-prohormone-b-type-natriuretic-peptide-as-independent-predictors-for-cardiovascular-disease-in-type-2-diabetes
#1
Marco Colombo, Helen C Looker, Bassam Farran, Felix Agakov, M Julia Brosnan, Paul Welsh, Naveed Sattar, Shona Livingstone, Paul N Durrington, D John Betteridge, Paul M McKeigue, Helen M Colhoun
BACKGROUND AND AIMS: Developing sparse panels of biomarkers for cardiovascular disease in type 2 diabetes would enable risk stratification for clinical decision making and selection into clinical trials. We examined the individual and joint performance of five candidate biomarkers for incident cardiovascular disease (CVD) in type 2 diabetes that an earlier discovery study had yielded. METHODS: Apolipoprotein CIII (apoCIII), N-terminal prohormone B-type natriuretic peptide (NT-proBNP), high sensitivity Troponin T (hsTnT), Interleukin-6, and Interleukin-15 were measured in baseline serum samples from the Collaborative Atorvastatin Diabetes trial (CARDS) of atorvastatin versus placebo...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29792862/the-reason-for-the-low-ca-2-sensitivity-of-thin-filaments-associated-with-the-glu41lys-mutation-in-the-tpm2-gene-is-freezing-of-tropomyosin-near-the-outer-domain-of-actin-and-inhibition-of-actin-monomer-switching-off-during-the-atpase-cycle
#2
Stanislava V Avrova, Olga E Karpicheva, Nikita A Rysev, Armen O Simonyan, Vladimir V Sirenko, Charles S Redwood, Yurii S Borovikov
The E41K mutation in TPM2 gene encoding muscle regulatory protein beta-tropomyosin is associated with nemaline myopathy and cap disease. The mutation results in a reduced Ca2+ -sensitivity of the thin filaments and in muscle weakness. To elucidate the structural basis of the reduced Ca2+ -sensitivity of the thin filaments, we studied multistep changes in spatial arrangement of tropomyosin (Tpm), actin and myosin heads during the ATPase cycle in reconstituted fibers, using the polarized fluorescence microscopy...
May 21, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29789900/associations-of-sensitive-cardiac-troponin-i-with-left-ventricular-morphology-function-and-prognosis-in-end-stage-renal-disease-patients-with-preserved-ejection-fraction
#3
Kenichiro Otsuka, Koki Nakanishi, Kenei Shimada, Haruo Nakamura, Hitoshi Inanami, Hiroki Nishioka, Kohei Fujimoto, Noriaki Kasayuki, Minoru Yoshiyama
Sensitive cardiac troponin I (cTnI) predicts all-cause and cardiovascular mortality in various clinical settings. However, its clinical significance in hemodialysis (HD) patients with preserved left ventricular ejection fraction (LVEF) has not been fully elucidated. This study investigated the association of cTnI with LV morphology and function, and its long-term outcome in HD patients with preserved LVEF. This prospective study consists of 96 HD patients with preserved LVEF (69 ± 8 years and 63% male) who underwent two-dimensional echocardiographic examination and biomarker tests including cTnI, brain natriuretic peptide, and high-sensitive C-reactive protein...
May 22, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29770799/heart-type-fatty-acid-binding-protein-h-fabp-as-a-biomarker-for-acute-myocardial-injury-and-long-term-post-ischemic-prognosis
#4
REVIEW
Xiao-Dong Ye, Yi He, Sheng Wang, Gordon T Wong, Michael G Irwin, Zhengyuan Xia
Acute myocardial infarction (AMI) is a life-threatening event. Even with timely treatment, acute ischemic myocardial injury and ensuing ischemia reperfusion injury (IRI) can still be difficult issues to tackle. Apart from radiological and other auxiliary examinations, laboratory tests of applicable cardiac biomarkers are also necessary for early diagnosis and close monitoring of this disorder. Heart-type fatty acid binding protein (H-FABP), which mainly exists inside cardiomyocytes, has recently emerged as a potentially promising biomarker for myocardial injury...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29770219/determinants-and-prognosis-of-high-sensitivity-cardiac-troponin-t-peak-plasma-concentration-in-patients-hospitalized-for-non-cardiogenic-shock
#5
Marie Caujolle, Jerome Allyn, Caroline Brulliard, Dorothée Valance, David Vandroux, Olivier Martinet, Nicolas Allou
Purpose: The aim of this study was to assess the determinants and prognostic value of high-sensitivity cardiac troponin T peak plasma concentration in intensive care unit patients with non-cardiogenic shock. Material and methods: A prospective observational cohort study was conducted in a single intensive care unit between November 2014 and December 2015. Results: During the study period, 206 patients were hospitalized in the intensive care unit for non-cardiogenic shock and the median peak high-sensitivity cardiac troponin T was 55...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29768313/the-incidence-of-myocardial-injury-after-loading-doses-of-clopidogrel-versus-prasugrel-in-the-candidates-for-percutaneous-coronary-intervention-a-randomized-controlled-trial
#6
Reza Rahmani, Laya Jiriaee, Zahra Jiriaee, Akbar Shafiee, Amir Farhang Zand Parsa
INTRODUCTION: Prevention of myocardial injury is an essential issue in percutaneous coronary intervention (PCI). We compared the incidence of myocardial injury after loading doses of clopidogrel versus prasugrel in the candidates for PCI. METHODS: In this randomized-controlled clinical trial, we enrolled 88 stable angina patients, candidate for PCI. Patients received either prasugrel (60 mg orally) (n = 42) or clopidogrel (600 mg orally) (n = 46). Serum levels of creatine phosphokinase muscle-brain type, cardiac troponin I, and high sensitive C-reactive protein were measured at baseline and 6 and 12 hours postprocedural...
June 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29764220/wide-range-crp-versus-high-sensitivity-crp-on-roche-analyzers-focus-on-low-grade-inflammation-ranges-and-high-sensitivity-cardiac-troponin-t-levels
#7
Denis Monneret, Fouzi Mestari, Shaedah Djiavoudine, Guillaume Bachelot, Maxime Cloison, Françoise Imbert-Bismut, Maguy Bernard, Pierre Hausfater, Jean-Marc Lacorte, Dominique Bonnefont-Rousselot
Wide-range C-reactive protein (wr-CRP) has been proposed as an economical alternative to high-sensitivity C-reactive protein (hs-CRP) for the evaluation of low-grade inflammation-associated cardiovascular risk (LGI-CVR). Concomitant values of serum hs-CRP and plasma wr-CRP ≤5 mg/L, and high-sensitivity cardiac troponin T (hs-cTnT), all assayed on Roche Diagnostics analyzers over a 1.8-year period, were extracted from a hospital laboratory database. Hs-CRP and wr-CRP values were compared (Bland-Altman method; Deming's correlation), then separately classified into low (<1 mg/L), moderate (1-3 mg/L) and high (>3 mg/L) LGI-CVR ranges for agreement test (κ), assessed before and after Deming's regression-based adjustment of wr-CRP (Adj-wr-CRP)...
May 15, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29760219/detectable-high-sensitivity-cardiac-troponin-within-the-population-reference-interval-conveys-high-5-year-cardiovascular-risk-an-observational-study
#8
Martin P Than, Sally J Aldous, Richard W Troughton, Christopher J Pemberton, A Mark Richards, Christopher M A Frampton, Christopher M Florkowski, Peter M George, Samantha Bailey, Joanna M Young, Louise Cullen, Jaimi H Greenslade, William A Parsonage, Brendan M Everett, W Frank Peacock, Allan S Jaffe, John W Pickering
BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit of detection and < upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality. METHODS: A prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29756512/profile-of-roche-s-elecsys-troponin-t-gen-5-stat-blood-test-a-high-sensitivity-cardiac-troponin-assay-for-diagnosing-myocardial-infarction-in-the-emergency-department
#9
Peter A Kavsak, James E Andruchow, Andrew D McRae, Andrew Worster
The Elecsys Troponin T Gen 5 STAT test (distributed in the United States (US) by Roche Diagnostics, Indianapolis, IN) is the first high-sensitivity cardiac troponin test approved for use by the FDA in the US (2017). Areas covered: The test offers clinicians the opportunity for more rapid decision-making for diagnosing myocardial infarction (MI) in the emergency department (ED). The Troponin T Gen 5 STAT test (labeled as TNT-G5ST on the reagent pack) is similar to the Troponin T hs STAT (TNT-HSST) and Troponin T hs (TNT-HS) tests that have been available outside the US since 2009...
May 12, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29755624/clinical-significance-of-skin-autofluorescence-in-patients-with-type-2-diabetes-mellitus-with-chronic-heart-failure
#10
Takashi Hitsumoto
Background: Recent clinical studies have shown that skin autofluorescence (AF) levels are significantly associated with diabetic complications. In contrast, data regarding the relationships between skin AF and chronic heart failure (CHF) are limited. The aim of this study was to clarify the clinical significance of skin AF in patients with type 2 diabetes mellitus (DM) with CHF. Methods: This cross-sectional study enrolled 257 outpatients with type 2 DM with CHF who were treated medically (96 men and 161 women; mean age, 79 ± 7 years)...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29753398/cardiovascular-risk-prediction-in-ckd
#11
REVIEW
Shoshana H Ballew, Kunihiro Matsushita
Cardiovascular disease is an important complication for patients with chronic kidney disease (CKD), warranting accurate risk prediction, but clinical guidelines are inconsistent regarding whether or how to use information on measures of CKD for predicting risk. Recent large meta-analyses have shown that key CKD measures (estimated glomerular filtration rate and albuminuria) improve cardiovascular risk prediction beyond traditional risk factors, especially when albuminuria is added to prediction models. In addition, several recent studies have shown that the use of filtration markers other than serum creatinine, cystatin C, and β2 -microglobulin can improve cardiovascular risk prediction...
May 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29750940/the-importance-of-low-level-qc-for-high-sensitivity-troponin-assays
#12
Peter E Hickman, Gus Koerbin, Tony Badrick, Carmen Oakman, Julia M Potter
BACKGROUND: With the advent of the new high-sensitivity troponin assays, it is becoming critical to measure troponin accurately to low concentrations. To ensure assay performance is acceptable, appropriate QC must be run. METHODS: In addition to the routine use of commercial QC material, we prepared pools of human QC material with low troponin concentrations close to the limit of quantitation, and ran these regularly on our laboratory analysers. RESULTS: Over 3 years we found no drift or shift in our hs-cTnI assay...
May 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29750939/first-high-sensitivity-cardiac-troponin-i-assay-cleared-by-the-united-states-food-and-drug-administration-validation-and-implications
#13
Robert H Christenson, Kristin Mullins, Show-Hong Duh
BACKGROUND: High-Sensitivity (hs) cardiac troponin (cTn) assays are categorized by two criteria: (i) cTn values above the limit of detection (LoD) for >50% of male and female healthy cohorts of ≥300 individuals; (ii) imprecision ≤10% total %CV for sex-specific 99th-percentile clinical decision values (CDVs). No documented hs-Tn assay has yet been FDA-cleared. METHODS: The PATHFAST cTnI-II assay's LoD was 2.3 ng/L using CLSI EP-17. The AACC Universal Sample Bank of 847 healthy men (50...
May 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29750937/the-potential-role-of-a-turbidimetric-heart-type-fatty-acid-binding-protein-assay-to-aid-in-the-interpretation-of-persistently-elevated-non-changing-cardiac-troponin-i-concentrations
#14
Peter A Kavsak, Craig Ainsworth, Donald M Arnold, Terry Scott, Lorna Clark, Josko Ivica, Katharine Mackett, Richard Whitlock, Andrew Worster
BACKGROUND: Elevated and non-changing high-sensitivity cardiac troponin (hs-cTn) concentrations may suggest a process other than acute injury, possibly due to chronic condition(s) causing the elevation, an analytical error/interference or the formation of macrocomplexes. Heart-type fatty acid binding protein (H-FABP) might be useful in this setting to identify the etiology of abnormally high and non-changing cTn concentrations which could aid clinical decision making in the hospital setting...
May 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29750698/peri-operative-copeptin-concentrations-and-their-association-with-myocardial-injury-after-vascular-surgery-a-prospective-observational-cohort-study
#15
Firmin Kamber, Eckhard Mauermann, Esther Seeberger, Lorenz Guerke, Christian Mueller, Daniel Bolliger, Giovanna A L Lurati Buse
BACKGROUND: Copeptin levels in conjunction with cardiac troponin may be used to rule out early myocardial infarction in patients presenting with chest pain. Raised pre-operative copeptin has been shown to be associated with postoperative cardiac events. However, very little is known about the peri-operative time course of copeptin or the feasibility of very early postoperative copeptin measurement to diagnose or rule-out myocardial injury. OBJECTIVES: In this preparatory analysis for a larger trial, we sought to examine the time course of peri-operative copeptin and identify the time at which concentrations returned to pre-operative levels...
May 9, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29748349/independent-prognostic-value-of-serum-soluble-st2-measurements-in-patients-with-heart-failure-and-a-reduced-ejection-fraction-in-the-paradigm-hf-trial-prospective-comparison-of-arni-with-acei-to-determine-impact-on-global-mortality-and-morbidity-in-heart-failure
#16
Eileen O'Meara, Margaret F Prescott, Brian Claggett, Jean L Rouleau, Lu-May Chiang, Scott D Solomon, Milton Packer, John J V McMurray, Michael R Zile
BACKGROUND: Soluble ST2 (sST2) is associated with cardiac remodeling and fibrosis. In chronic heart failure, the predictive value of sST2 has not been evaluated in a model that includes both NT-proBNP (N-terminal pro-B-type natriuretic peptide) and hs-TnT (high-sensitivity cardiac troponin T), in a trial in which treatment had a major impact. Therefore, the effects of treatment on sST2 levels in PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the relationships between sST2 and outcomes, and the prognostic utility of various sST2 partition values were examined...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29746826/high-sensitivity-cardiac-troponin-i-and-risk-of-incident-atrial-fibrillation-hospitalisation-in-an-australian-community-based-cohort-the-busselton-health-study
#17
Kun Zhu, Joseph Hung, Mark Divitini, Kevin Murray, Ee Mun Lim, Andrew St John, John P Walsh, Matthew Knuiman
OBJECTIVE: The identification of individuals at risk of atrial fibrillation (AF) remains a challenge. We investigated whether high-sensitive cardiac troponin I (hs-cTnI) is an independent predictor of incident atrial fibrillation (AF) hospitalisation in an Australian community-based cohort. METHODS: Serum hs-cTnI was measured in 1641 men and 2189 women in the Busselton Health Study 1994/1995 Cohort aged 25-84 years at baseline. Data on incident AF hospitalisation over 20 years follow-up were obtained by data linkage...
May 7, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29737871/circulating-biomarkers-of-hypertrophy-and-fibrosis-in-patients-with-hypertrophic-cardiomyopathy-assessed-by-cardiac-magnetic-resonance
#18
Monika Gawor, Mateusz Śpiewak, Agata Kubik, Aleksandra Wróbel, Anna Lutyńska, Magdalena Marczak, Jacek Grzybowski
PURPOSE: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. METHODS: Levels of biomarkers: soluble ST2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15), NT-proBNP, and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29735888/rapid-and-sensitive-detection-of-cardiac-troponin-i-for-point-of-care-tests-based-on-red-fluorescent-microspheres
#19
Yanxue Cai, Keren Kang, Qianru Li, Yu Wang, Xiaowei He
A reliable lateral flow immunoassay (LFIA) based on a facile one-step synthesis of single microspheres in combining with immunochromatography technique was developed to establish a new point-of-care test (POCT) for the rapid and early detection of cardiac troponin I (cTnI), a kind of cardiac specific biomarker for acute myocardial infarction (AMI). The double layered microspheres with clear core-shell structures were produced using soap-free emulsion polymerization method with inexpensive compounds (styrene and acrylic acid)...
May 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29735525/orthostatic-hypotension-and-risk-of-clinical-and-subclinical-cardiovascular-disease-in-middle-aged-adults
#20
Stephen P Juraschek, Natalie Daya, Lawrence J Appel, Edgar R Miller, John William McEvoy, Kunihiro Matsushita, Christie M Ballantyne, Elizabeth Selvin
BACKGROUND: Although orthostatic hypotension (OH) is a well-recognized manifestation of neuropathy and hypovolemia, its contribution to cardiovascular disease (CVD) risk is controversial. METHODS AND RESULTS: Participants with OH, defined as a decrease in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) from the supine to standing position, were identified during the first visit of the ARIC (Atherosclerosis Risk in Communities) Study (1987-1989) within 2 minutes of standing...
May 7, 2018: Journal of the American Heart Association
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