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https://www.readbyqxmd.com/read/27919826/should-blood-pressure-goal-be-individualized-in-hypertensive-patients
#1
REVIEW
Alexandra Yannoutsos, Rania Kheder-Elfekih, Jean-Michel Halimi, Michel E Safar, Jacques Blacher
The aim of the present review is to consider the clinical relevance of individualized blood pressure (BP) goal under treatment in hypertensive patients according to their age, comorbidities or established cardiovascular (CV) disease. Evidence from large-scale randomized trials to support a lower BP goal, as initially recommended by guidelines in high-risk hypertensive patients, were lacking. Recently, the randomized intervention SPRINT trial studied two treatment targets for systolic BP (120mm Hg versus 140mm Hg in the intensive and standard treatment group, respectively) among high-risk hypertensive patients, without diabetes and without a history of prior stroke...
December 2, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27898415/hypotension-and-adverse-outcomes-in-prematurity-comparing-definitions
#2
Deidre St Peter, Christiana Gandy, Suma B Hoffman
BACKGROUND: In the premature neonate, there is no consensus regarding normal blood pressure (BP). The most common definition used is a mean arterial BP (MAP) less than the gestational age (GA); however, studies indicate that the neuroprotective mechanism of autoregulation is lost below a MAP of 30 mm Hg. OBJECTIVE: To determine whether hypotension defined as MAP <30 mm Hg or MAP less than the infant's GA better predicts adverse outcomes of intraventricular hemorrhage (IVH) and death...
November 30, 2016: Neonatology
https://www.readbyqxmd.com/read/27895487/combination-therapy-with-lercanidipine-and-enalapril-in-the-management-of-the-hypertensive-patient-an-update-of-the-evidence
#3
REVIEW
Christina Antza, Stella Stabouli, Vasilios Kotsis
Hypertension is an important risk factor for premature death as it increases the probability of stroke, myocardial infarction, and heart failure. Antihypertensive drugs can decrease cardiovascular (CV) morbidity and mortality. The majority of hypertensive patients need more than one antihypertensive agent to attain blood pressure (BP) targets. Monotherapy can effectively reduce BP only in 20%-40% of patients. Multiple mechanisms including increased peripheral vascular resistance, increased cardiac work, and hypervolemia are involved in the pathogenesis of hypertension...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27882768/-adrenocortical-oncocytoma-presenting-as-cushing%C3%A2-s-syndrome-in-pregnancy-with-spontaneous-postpartum-uterine-rupture
#4
M Kotoulová, I Mikysková, J Dušková, J Vláčil, M Dvořák, M Halaška
OBJECTIVE: The description of rare case of the Cushings syndrome in pregnancy resulting in the spontaneous rupture of uterus. DESIGNS: A case report. SETTING: Department of Gynecology and Obstetrics, 1st Medical Faculty of Charles University and Hospital Na Bulovce. CASE REPORT: The authors report the case of a 33 year old woman, who was admitted to the clinic in 30th week of pregnancy for elevated blood pressure and hypokalemia...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27872051/management-of-mild-hypertension-in-adults
#5
REVIEW
Anthony J Viera, Emily M Hawes
Elevated blood pressure is a common risk factor for cardiovascular disease and affects one in three adults. Blood pressure lowering drugs substantially reduce the risk of stroke, coronary heart disease, heart failure, and premature death, but most clinical trials showing benefits have primarily included patients with moderate to severe hypertension, known cardiovascular disease, or elevated risk of cardiovascular disease. The benefits of treating mild hypertension in patients without cardiovascular disease are less clear, but recent meta-analyses offer some insights...
November 21, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27869965/-new-century-new-challenges-changes-in-the-burden-of-disease-profile-in-brazil-1990-2010
#6
Fatima Marinho, Valéria Maria de Azeredo Passos, Elisabeth Barboza França
OBJECTIVE: to describe the burden of disease in Brazil from 1990 to 2010. METHODS: analysis of the estimates of the Global Burden of Disease Study 2010 - Years of Life Lost due to premature mortality (YLL), Years Lost due to Disability (YLD), Disability-Adjusted Life Year (DALY=YLL+YLD) and risk factors. RESULTS: there was a decrease in deaths due to diarrhea and an increase in deaths due to diabetes and kidney disease, whilst deaths due to homicides and traffic accidents remained stable; cardiovascular diseases continued to be the leading cause of death despite a 30% reduction; the largest increases in DALY were due to diabetes and musculoskeletal diseases in women and alcohol abuse and low back pain in men; the main risk factors were poor diet and high blood pressure; smoking, domestic pollution and insufficient breastfeeding were found to have reduced...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27865291/adiposity-and-cardiovascular-risk-factor-variables-in-childhood-are-associated-with-premature-death-from-coronary-heart-disease-in-adults-the-bogalusa-heart-study
#7
Gerald S Berenson, Sathanur R Srinivasan, Ji Hua Xu, Wei Chen
BACKGROUND: More than 600 deaths of all causes have been documented over the 40-year duration of the Bogalusa Heart Study. Of these, 97 deaths have been related to cardiovascular events, based on obituaries published in local newspapers, death certificates obtained from the State Health Department, information from the coroner and word of mouth by nursing staff from the community. METHODS: This study was a retrospective longitudinal cohort with several observations of each subject...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27864167/testing-the-feasibility-of-remote-patient-monitoring-in-prenatal-care-using-a-mobile-app-and-connected-devices-a-prospective-observational-trial
#8
Kathryn I Marko, Jill M Krapf, Andrew C Meltzer, Julia Oh, Nihar Ganju, Anjali G Martinez, Sheetal G Sheth, Nancy D Gaba
BACKGROUND: Excessive weight gain and elevated blood pressure are significant risk factors for adverse pregnancy outcomes such as gestational diabetes, premature birth, and preeclampsia. More effective strategies to facilitate adherence to gestational weight gain goals and monitor blood pressure may have a positive health benefit for pregnant women and their babies. The impact of utilizing a remote patient monitoring system to monitor blood pressure and weight gain as a component of prenatal care has not been previously assessed...
November 18, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27845713/novel-approaches-to-investigate-one-carbon-metabolism-and-related-b-vitamins-in-blood-pressure
#9
REVIEW
Amy McMahon, Helene McNulty, Catherine F Hughes, J J Strain, Mary Ward
Hypertension, a major risk factor for heart disease and stroke, is the world's leading cause of preventable, premature death. A common polymorphism (677C→T) in the gene encoding the folate metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) is associated with increased blood pressure, and there is accumulating evidence demonstrating that this phenotype can be modulated, specifically in individuals with the MTHFR 677TT genotype, by the B-vitamin riboflavin, an essential co-factor for MTHFR. The underlying mechanism that links this polymorphism, and the related gene-nutrient interaction, with hypertension is currently unknown...
November 11, 2016: Nutrients
https://www.readbyqxmd.com/read/27821757/nicotinamide-benefits-both-mothers-and-pups-in-two-contrasting-mouse-models-of-preeclampsia
#10
Feng Li, Tomofumi Fushima, Gen Oyanagi, H W Davin Townley-Tilson, Emiko Sato, Hironobu Nakada, Yuji Oe, John R Hagaman, Jennifer Wilder, Manyu Li, Akiyo Sekimoto, Daisuke Saigusa, Hiroshi Sato, Sadayoshi Ito, J Charles Jennette, Nobuyo Maeda, S Ananth Karumanchi, Oliver Smithies, Nobuyuki Takahashi
Preeclampsia (PE) complicates ∼5% of human pregnancies and is one of the leading causes of pregnancy-related maternal deaths. The only definitive treatment, induced delivery, invariably results in prematurity, and in severe early-onset cases may lead to fetal death. Many currently available antihypertensive drugs are teratogenic and therefore precluded from use. Nonteratogenic antihypertensives help control maternal blood pressure in PE, but results in preventing preterm delivery and correcting fetal growth restriction (FGR) that also occurs in PE have been disappointing...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27819152/blood-pressure-and-lipid-target-adherence-in-korean-patients-receiving-angiotensin-ii-receptor-blockers-statin-regimens
#11
Hyun-Jin Kim, Eugene Kim, Kyoung-Bok Min, Jin-Young Min
OBJECTIVES: Hypertension and dyslipidemia are important cardiovascular risk factors. Simultaneously controlling blood pressure (BP) and lipid levels is effective in preventing cardiovascular events and premature death. This study investigated the association between adherence to angiotensin II receptor blocker (ARB)/statin regimens and BP or low density lipoprotein-cholesterol (LDL-C) target attainment in Korean patients with concomitant hypertension and dyslipidemia. METHODS: In this retrospective, multicenter study, we collected case report forms (CRFs) of hypertensive patients with concomitant dyslipidemia who were prescribed an ARB/statin regimen between 1 April 2014 and 31 March 2015 from 51 outpatient clinics...
December 2, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27808645/getting-serious-about-prevention
#12
Jamie Waterall
An estimated two thirds of premature deaths could be prevented by addressing public health issues such as poor diet, being overweight, smoking and high blood pressure. The NHS Five Year Forward View strategy from NHS England and Public Health England's From Evidence into Action both call for a much greater focus on prevention.
October 19, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27805349/infantile-preductal-coarctation-of-aorta-presenting-as-cerebellar-infarct-a-rare-presentation
#13
A Sivaraman, Maniram Kumhar, Utsav Kimar Sahu, Manoj Kumar Mali
Coarctation of aorta is a common congenital heart defect. The diagnosis may be missed unless a highindex of suspicion is maintained, and is often delayed until the patient develops congestive heart failure (CHF), (common in infants) or hypertension (common in older children). It seldom goes undiagnosed till adulthood and frequently leads to complications as a result of long-standing high blood pressure. Intracranial haemorrhage, premature coronary artery disease, aortic aneurysms and rupture have all been reported...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27800597/racial-discrimination-and-stigma-consciousness-are-associated-with-higher-blood-pressure-and-hypertension-in-minority-men
#14
Heather Orom, Chaman Sharma, Gregory G Homish, Willie Underwood, D Lynn Homish
OBJECTIVE: We examined whether lifetime racial discrimination and stigma consciousness (expecting to be stigmatized) are associated with blood pressure in minority and White middle-aged and older adult men. DESIGN: Participants were 1533 men (mean age = 63.2 [SD = 7.9, range = 37.4-89.2]; 12.4 % Black, 7.8 % Hispanic, 2.0 % other) diagnosed with clinically localized prostate cancer. We separately modeled associations between discrimination/stigma consciousness and blood pressure outcomes for minorities and Whites controlling for education, income, employment status, age, marital status, BMI, and recruitment site...
October 31, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27799653/-reboa-is-it-really-safe-a-case-with-massive-intracranial-hemorrhage-possibly-due-to-endovascular-balloon-occlusion-of-the-aorta-reboa
#15
Hayaki Uchino, Nobuichiro Tamura, Ryosuke Echigoya, Tetsunori Ikegami, Toshio Fukuoka
BACKGROUND Non-compressible torso hemorrhage continues to be the leading cause of preventable death in trauma patients. Recent case series report that resuscitative endovascular balloon occlusion of the aorta (REBOA) in the trauma population is a technically feasible method to manage the patients with exsanguinating hemorrhage. On the other hand, it seems that REBOA is being widely promoted prematurely. Complications due to REBOA haven't been reported much in the literature, and they could have been underestimated...
November 1, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27793212/the-newfoundland-and-labrador-bariatric-surgery-cohort-study-rational-and-study-protocol
#16
Laurie K Twells, Deborah M Gregory, William K Midodzi, Carla Dillon, Christopher S Kovacs, Don MacDonald, Kendra K Lester, David Pace, Chris Smith, Darrell Boone, Raleen Murphy
BACKGROUND: In Canada, there has been a disproportionate increase in adults with Class II (BMI 35.0-39.9 kg/m(2)) or Class III obesity (BMI ≥ 40 kg/m(2)) affecting 9 % of Canadians with increases projected. Individuals affected by severe obesity (BMI ≥ 35) are at increased risk of high blood pressure, cardiovascular disease, diabetes, cancer, impaired quality of life, and premature mortality. Bariatric surgery is the most effective treatment for severe obesity. Laparoscopic sleeve gastrectomy (LSG), a relatively new type of bariatric surgery, is growing in popularity as a treatment...
October 28, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27790472/arterial-stiffness-and-trace-elements-in-apparently-healthy-population-a-cross-sectional-study
#17
Gangapatnam Subrahmanyam, Rama Mohan Pathapati, Krishnan Ramalingam, Selvam Armugam Indira, Katari Kantha, Bhemasen Soren
INTRODUCTION: Stiffening of arteries is a natural ageing process. Any diseases/disorders or risk factors that escalate oxidative stress, microvascular inflammation and endothelial damage may promote to premature vascular stiffening. Any imbalance in these trace element levels may independently contribute to the changes in the components in the arterial wall and thus, arterial stiffness via one or more mechanisms. AIM: To evaluate the severity of arterial stiffness in apparently healthy population and also to evaluate role of various risk factors and trace elements in the severity of arterial stiffness...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27788744/-clinical-analysis-of-19-cases-of-pregnant-women-with-rapid-arrhythmia-in-the-treatment-of-radiofrequency-catheter-ablation
#18
L Chu, J Zhang, Y N Li, D Y Long
: Objective: To investigate the risk of radiofrequency catheter ablation and maternal and infant in pregnant women with rapid arrhythmia during pregnancy. Methods: The clinical data of the 19 cases of pregnancy complicated with rapid arrhythmia were retrospectively analyzed and followed up, including the gestational week, the type of arrhythmia, the treatment, and the outcome of the mother and child in Beijing Anzhen Hospital of Capital Medical University from January 2002 to March 2016...
October 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27768660/identifying-potential-utility-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta-an-autopsy-study
#19
Bellal Joseph, Kareem Ibraheem, Ansab A Haider, Narong Kulvatunyou, Andrew Tang, Terence O'Keeffe, Zachary M Bauman, Donald J Green, Rifat Latifi, Peter Rhee
BACKGROUND: Resuscitative thoracotomy (RT) has been the standard therapy in patients with acute arrest due to hemorrhagic shock. However, with the development of resuscitative endovascular balloon occlusion of the aorta (REBOA), its role as a potential adjunct to a highly morbid intervention such as RT is being discussed. The aim of this study was to identify patients who most likely would have potentially benefited from REBOA use based on autopsy findings. METHODS: We performed a 4-year retrospective review of all RTs performed at our Level I trauma center...
November 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27759454/perinatal-outcome-in-pregnancies-complicated-with-gestational-diabetes-mellitus-and-very-preterm-birth-case-control-study
#20
E G Deryabina, G V Yakornova, L A Pestryaeva, N D Sandyreva
Preterm birth is defined as all births before 37 completed weeks of gestation. Preterm birth can be further sub-divided based on gestational age: extremely preterm (<28 weeks), very preterm (28 to <32 weeks) and moderate preterm (32 to <37 weeks). Retrospective observational case-control study review (1 year i.e., 2015) is to assess pregnancy outcome among women with gestational diabetes mellitus (GDM) delivering very preterm (28 + 0/7 to 31 + 6/7 weeks of gestation). The study group included all women diagnosed with GDM and were compared to a control group of women delivering at the same gestational age period but without GDM...
October 2016: Gynecological Endocrinology
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