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L Bourgoin, L Caeymaex, F Decobert, C Jung, C Danan, X Durrmeyer
AIM: Less invasive surfactant administration (LISA) can avoid tracheal intubation for neonatal respiratory distress syndrome, but can be painful because it requires laryngoscopy. The aim of this study was to assess the efficacy and tolerance of intravenous atropine plus ketamine administration before LISA. METHODS: We conducted a prospective observational study of all premature infants hospitalised in our French neonatal intensive care unit treated with LISA between March 2015 and March 2016...
March 13, 2018: Acta Paediatrica
Danielle A Guimaraes, Madla A Dos Passos, Elen Rizzi, Lucas C Pinheiro, Jefferson H Amaral, Raquel F Gerlach, Michele M Castro, Jose E Tanus-Santos
Cardiac hypertrophy is a common consequence of chronic hypertension and leads to heart failure and premature death. The anion nitrite is now considered as a bioactive molecule able to exert beneficial cardiovascular effects. Previous results showed that nitrite attenuates hypertension-induced increases in reactive oxygen species (ROS) production in the vasculature. Whether antioxidant effects induced by nitrite block critical signaling pathways involved in cardiac hypertrophy induced by hypertension has not been determined yet...
March 9, 2018: Free Radical Biology & Medicine
Bian Liu, Kui Kai Lau, Linxin Li, Caroline Lovelock, Ming Liu, Wilhelm Kuker, Peter M Rothwell
BACKGROUND AND PURPOSE: It has been hypothesized that cerebral small vessel disease (SVD) and chronic renal impairment may be part of a multisystem small-vessel disorder, but their association may simply be as a result of shared risk factors (eg, hypertension) rather than to a systemic susceptibility to premature SVD. However, most previous studies were hospital based, most had inadequate adjustment for hypertension, many were confined to patients with lacunar stroke, and none stratified by age...
March 9, 2018: Stroke; a Journal of Cerebral Circulation
Tomoyuki Shimokaze, Katsuaki Toyoshima, Jun Shibasaki, Yasufumi Itani
OBJECTIVE: We often encounter infants who developed hypokalaemia following low-dose doxapram for apnea of prematurity (AOP). AIMS: To determine changes in blood potassium (K+) levels after doxapram administration. STUDY DESIGN: We studied infants born before 30 weeks gestation. Doxapram (0.1-0.3 mg/kg/h) in addition to methylxanthines was used to treat AOP refractory to methylxanthines. RESULTS: Twenty-five infants received doxapram were studied...
March 7, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Jennifer Yurkovich, Debra S Burns, Tondi Harrison
Background: Although evidence suggests music therapy lowers the heart rate of ill adults undergoing painful procedures and premature infants in the NICU, the effect of music therapy interventions on physiologic response in infants with congenital heart disease (CHD) being cared for in the cardiac intensive care unit (CICU) has not been explored. Objective: The purpose of this study was to explore the effect of the music therapy entrainment on physiologic responses of infants with CHD in the CICU...
March 5, 2018: Journal of Music Therapy
R Ivanovs, A Kivite, D Ziedonis, I Mintale, J Vrublevska, E Rancans
BACKGROUND: Cardiovascular (CV) diseases (CVDs) are the leading cause of mortality worldwide. Globally, there is a growing interest in understanding and addressing modifiable psychosocial risk factors, particularly depression and anxiety, to prevent CVDs and to reduce morbidity and mortality. Despite the high premature mortality rate from CVDs in Latvia, this is the first Latvian study to examine the association of depression and anxiety with CVD morbidity in a primary care population...
March 6, 2018: BMC Public Health
Marshall M Mrocki, Vivian B Nguyen, Paul Lombardo, Megan R Sutherland, Jonathan G Bensley, Ilias Nitsos, Beth J Allison, Richard Harding, Robert De Matteo, Michal Schneider, Graeme R Polglase, M Jane Black
Preterm birth prematurely exposes the immature heart to the haemodynamic transition at birth, which has the potential to induce abnormal cardiac remodelling. Magnetic resonance imaging studies in young adults born preterm have shown abnormalities in the gross structure of the ventricles (particularly the right ventricle; RV), but the cellular basis of these alterations is unknown. The aim of this study, conducted in sheep, was to determine the effect of moderate preterm birth on RV cellular structure and function in early adulthood...
March 6, 2018: Journal of Physiology
Irma Isordia-Salas, José A Alvarado-Moreno, Rosa M Jiménez-Alvarado, Jesús Hernández-Juárez, David Santiago-Germán, Alfredo Leaños-Miranda, Abraham Majluf-Cruz
: The renin-angiotensin system plays an important role in the regulation of blood pressure and the development of coronary artery disease. The aim was to examine the association of the insertion deletion in the angiotensin-converting enzyme gene, M235T and T174M polymorphisms in the angiotensinogen gene with ST elevation acute myocardial infarction (STEAMI) in young Mexican population. We analyzed 242 unrelated patients with STEAMI 45 or less years of age, admitted to a cardiovascular intense care unit, and 242 individuals without STEAMI matched by age and sex, recruited from January 2006 and June 2013...
February 22, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Don P Wilson, Luke Hamilton, Jose Gonzalez
BACKGROUND: Individuals diagnosed with diabetes mellitus have an increased risk of cardiovascular disease, often leading to morbidity and premature mortality. As the number of youth developing T1D and T2D continues to grow, this early onset predisposes patients to a longer burden of disease and earlier onset of cardiovascular complications. Early identification and effective management and treatment of these risk factors can lead to decreased cardiovascular events and improved quality of life...
February 21, 2018: Current Pediatric Reviews
Maryse C J Osté, António W Gomes-Neto, Eva Corpeleijn, Rijk O B Gans, Martin H de Borst, Else van den Berg, Sabita S Soedamah-Muthu, Daan Kromhout, Gerjan J Navis, Stephan J L Bakker
Renal transplant recipients (RTR) are at risk of decline of graft function and premature mortality, with high blood pressure as important risk factor for both. To study the association of the Dietary Approach to Stop Hypertension (DASH) diet with these adverse events, we conducted a prospective cohort study of adult RTR. Dietary data was collected using a validated 177-item food frequency questionnaire and an overall DASH-score was obtained. We included 632 stable RTR (mean±SD age: 53.0±12.7 y, 57% men). Mean DASH score was 23...
February 21, 2018: American Journal of Transplantation
Yuehong Li, Wei Wang, Yujuan Wang, Qi Chen
BACKGROUND Analysis the maternal and fetal risk predictors in pregnancy in conjunction with chronic glomerulonephritis (CGN) patients are helpful to understand the influence of kidney diseases on pregnancy and the effects of pregnancy on kidney diseases. The aim of this study was to determine the predictors of adverse maternal and fetal outcomes in CGN patients. MATERIAL AND METHODS Maternal and fetal outcomes in 64 pregnancies of CGN patients were retrospectively analyzed. We randomly selected 100 low-risk-pregnancy women without chronic kidney disease (CKD) at the same time as the control group...
February 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Chih-Cheng Hsu, Mark L Wahlqvist, I-Chien Wu, Yu-Hung Chang, I-Shou Chang, Yi-Fen Tsai, Ting-Ting Liu, Chwen Keng Tsao, Chao A Hsiung
BACKGROUND: The effect of cardio-metabolic profile on the relationship of body mass index (BMI) with mortality is unclear. The aim of this study was to explore association between BMI and mortality at all ages, taking account of cardio-metabolic disorders. METHODS: We followed 377,929 individuals (≥ 20 years), who registered for health checkups in 1996-2007, until 2008 and found 9490 deaths. From multivariable Cox proportional hazards models we estimated mortality hazard ratios (HR) for those in high blood pressure, hyperglycemia, high waist circumference, dyslipidemia, and different BMIs categories (the underweight [< 18...
February 14, 2018: BMC Public Health
Krithiga Shridhar, Ambika Satija, Preet K Dhillon, Sutapa Agrawal, Ruby Gupta, Liza Bowen, Sanjay Kinra, A V Bharathi, D Prabhakaran, K Srinath Reddy, Shah Ebrahim
BACKGROUND: Dietary patterns (DPs) in India are heterogenous. To date, data on association of indigenous DPs in India with risk factors of nutrition-related noncommunicable diseases (cardiovascular disease and diabetes), leading causes of premature death and disability, are limited. We aimed to evaluate the associations of empirically-derived DPs with blood lipids, fasting glucose and blood pressure levels in an adult Indian population recruited across four geographical regions of India...
February 8, 2018: Nutrition Journal
Fang-Fei Wei, Anke Raaijmakers, Zhen-Yu Zhang, Theun Pieter van Tienoven, Qi-Fang Huang, Wen-Yi Yang, Lutgarde Thijs, Harry A J Struijker-Boudier, Peter Verhamme, Karel Allegaert, Jan A Staessen
BACKGROUND: Retinal microvessels can be visualized non-invasively and mirror the status of the cerebral microvasculature. AIMS: To investigate whether in young children born prematurely or at term cognitive performance is related to retinal microvascular traits. STUDY DESIGN, SUBJECTS: In 93 prematurely born infants (birth weight < 1000 g) and 87 controls born at term, we measured head circumference (HC) and determined intelligence quotient (IQ) by combining matrix reasoning and spatial span (Wechsler Non-Verbal test, Dutch version) and post-processed retinal photographs using Singapore I Vessel Assessment software (version 3...
February 3, 2018: Early Human Development
Keun Her, Joon Yeong Kim, Ki Moo Lim, Seong Wook Choi
BACKGROUND: Counter-pulsation control (CPC) by ventricular assist devices (VADs) is believed to reduce cardiac load and increase coronary perfusion. However, patients with VADs have a higher risk of arrhythmia, which may cause the CPC to fail. Consequently, CPC has not been applied by VADs in clinical practice. The phase-locked loop (PLL) algorithm for CPC is readily implemented in VADs; however, it requires a normal, consistent heartbeat for adequate performance. When an arrhythmia occurs, the algorithm maintains a constant pumping rate despite the unstable heartbeat...
February 2, 2018: Biomedical Engineering Online
Hongwei Ji, Jiadela Teliewubai, Yuyan Lu, Jing Xiong, Shikai Yu, Chen Chi, Jue Li, Jacques Blacher, Yi Zhang, Yawei Xu
OBJECTIVES: Vascular aging represents a mediating step between risk factors and cardiovascular events, and preclinical target organ damage (TOD) integrates the cumulative effect of cardiovascular risk factors. This study is aimed at the relationships between vascular aging and TOD. METHODS: Two thousand and ninety-eight participants (45.52% men, aged 71.3 ± 6.1 years) were recruited from June 2014 to June 2017 from the communities in the northern Shanghai area...
January 31, 2018: Journal of Hypertension
Johan Björkqvist, Anu-Katriina Pesonen, Liisa Kuula, Hanna-Maria Matinolli, Aulikki Lano, Marika Sipola-Leppänen, Marjaana Tikanmäki, Dieter Wolke, Marjo-Riitta Järvelin, Johan G Eriksson, Sture Andersson, Marja Vääräsmäki, Kati Heinonen, Katri Räikkönen, Petteri Hovi, Eero Kajantie
A preference for eveningness (being a "night owl") and preterm birth (<37 weeks of gestation) are associated with similar adversities, such as elevated blood pressure, impaired glucose regulation, poorer physical fitness, and lower mood. Yet, it remains unclear if and how preterm birth is associated with circadian preference. The aim of this study was to assess this association across the whole gestation range, using both objective and subjective measurements of circadian preference. Circadian preference was measured among 594 young adults (mean age 24...
January 30, 2018: Chronobiology International
Emilie Agardh, Anna-Karin Danielsson, Peter Guban, Anton Lager, Rynaz Rabiee, Peter Allebeck
Previous studies in Sweden have focused on a number of indicators to assess and compare health conditions at regional levels over time. In this study we aimed to give a more complete picture of the health situation in Stockholm County compared to the rest of Sweden, by using the DALY measure (disability-adjusted life years). DALY combines life lost to premature death (YLL) and years lived with disability (YLD) in one measure, and also allow comparisons of fatal and non-fatal conditions. This approach reveals that low back and neck pain and ischemic heart disease dominated the disease burden in 2015...
January 22, 2018: Läkartidningen
Luiz Rodrigo Augustemak de Lima, Edio Luiz Petroski, Yara Maria Franco Moreno, Diego Augusto Santos Silva, Erasmo Benício de Moraes Santos Trindade, Aroldo Prohmann de Carvalho, Isabela de Carlos Back
HIV-infected children and adolescents may be at risk for cardiovascular disease due to chronic inflammation and exacerbation of risk factors. The aim of this study was as follows: 1) compare cardiovascular risk factors, chronic inflammation, and carotid intima-media thickness (IMTc) between the HIV and control groups; 2) determine the association of HIV and antiretroviral (ART) regimens with cardiovascular risk factors, chronic inflammation, and IMTc; and 3) identify variables associated with elevated IMTc...
2018: PloS One
L G Sisti, M Dajko, P Campanella, E Shkurti, W Ricciardi, C de Waure
Cardiovascular diseases (CVDs) are the leading cause of premature mortality and disability accounting for one third of all deaths worldwide with considerable impacts on economics and on the quality of life. The evidence suggests that a multifactorial lifestyle intervention might have a role in the CVDs risk reduction, especially in the risk populations, nonetheless the effects on modifiable CVDs risk factors have not been completely explored. Our work aimed at evaluating the impact of multifactorial lifestyle interventions on cardiovascular risk modification, both in the general and risk population...
December 29, 2017: Preventive Medicine
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