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https://www.readbyqxmd.com/read/29773827/cardiac-pacemaker-channel-hcn4-inhibition-and-atrial-arrhythmogenesis-after-releasing-cardiac-sympathetic-activation
#1
Kristine Chobanyan-Jürgens, Karsten Heusser, David Duncker, Christian Veltmann, Marcus May, Heidrun Mehling, Friedrich C Luft, Christoph Schröder, Jens Jordan, Jens Tank
Clinical trials and studies with ivabradine implicate cardiac pacemaker channels (HCN4) in the pathogenesis of atrial arrhythmias. Because acute changes in cardiac autonomic tone predispose to atrial arrhythmias, we studied humans in whom profound cardiac sympathetic activation was rapidly relieved to test influences of HCN4 inhibition with ivabradine on atrial arrhythmias. We tested 19 healthy participants with ivabradine, metoprolol, or placebo in a double blind, randomized, cross-over fashion on top of selective norepinephrine reuptake inhibition with reboxetine...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29759625/post-extrasystolic-potentiation-as-a-predictor-of-recovery-of-left-ventricular-dysfunction-after-radiofrequency-catheter-ablation
#2
Balaji Krishnan, Ashwini Sankar, Inder Anand, Selcuk Adabag, Jian-Ming Li, Edward O McFalls, David G Benditt, Kalyanam Shivkumar, Venkatakrishna N Tholakanahalli
OBJECTIVES: This study hypothesizes that post-extrasystolic potentiation reflects left ventricle contractile reserve and therefore may predict an improvement of premature ventricular contraction (PVC)-induced cardiomyopathy after PVC ablation. BACKGROUND: Post-extrasystolic potentiation is a physiologic phenomenon of blood pressure accentuation after a PVC beat. METHODS: We performed a retrospective study of patients with a PVC burden of ≥10% PVC/24 h and left ventricular ejection fraction (LVEF) of <50% who underwent successful ablation between January 1, 2009, to June 30, 2015...
November 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29753399/cardiovascular-disease-and-diabetic-kidney-disease
#3
REVIEW
Muhammad Maqbool, Mark E Cooper, Karin A M Jandeleit-Dahm
Diabetic kidney disease commonly is associated with an increased risk of cardiovascular disease. There are traditional common risk factors for both conditions including hypertension and poor glycemic control. However, it is likely that there are other pathophysiological mechanisms that explain the clinical phenomenon of increased cardiovascular disease in diabetic patients with chronic kidney and vice versa. Current management of both conditions includes aggressive glucose and blood pressure control. The protective role of treating dyslipidemia has been shown for cardiovascular disease, but the results for renal disease are not as clear...
May 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29747326/-current-status-and-the-consistency-analysis-of-using-two-criteria-for-decision-making-of-aspirin-use-for-the-primary-prevention-of-ischemic-cardiovascular-disease-in-outpatients
#4
H J Zuo, L Q Deng, J W Wang
Objective: To compare the consistency and accuracy of using 2 criteria for decision making of aspirin use for the primary prevention of ischemic cardiovascular disease (ISCVD) and explore the current status and related factors of aspirin use for the primary prevention of ISCVD in Chinese outpatients. Methods: This cross-sectional study enrolled 3 018 outpatients with hypertension, diabetes, or hypercholesterolemia, who visited the General Practice (GP) clinics of Anzhen hospital in Beijing from September to December 2015 were enrolled in...
April 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29735633/atrial-fibrillation-detection-during-24-hour-ambulatory-blood-pressure-monitoring-comparison-with-24-hour-electrocardiography
#5
Anastasios Kollias, Antonios Destounis, Petros Kalogeropoulos, Konstantinos G Kyriakoulis, Angeliki Ntineri, George S Stergiou
This study assessed the diagnostic accuracy of a novel 24-hour ambulatory blood pressure (ABP) monitor (Microlife WatchBP O3 Afib) with implemented algorithm for automated atrial fibrillation (AF) detection during each ABP measurement. One hundred subjects (mean age 70.6±8.2 [SD] years; men 53%; hypertensives 85%; 17 with permanent AF; 4 paroxysmal AF; and 79 non-AF) had simultaneous 24-hour ABP monitoring and 24-hour Holter monitoring. Among a total of 6410 valid ABP readings, 1091 (17%) were taken in ECG AF rhythm...
May 7, 2018: Hypertension
https://www.readbyqxmd.com/read/29734941/infective-endocarditis-due-to-burkholderia-cepacia-in-a-neonate-a-case-report
#6
Emir Yonas, Vito Damay, Raymond Pranata, Nuvi Nusarintowati
BACKGROUND: Burkholderia is a pathogen that is rarely seen in clinical cases. However, this organism is being found more commonly in hospitals. CASE PRESENTATION: A female Indonesian newborn was referred to our neonatal intensive care unit because of respiratory distress. The newborn had been delivered the previous night via cesarean section. A physical examination revealed intercostal retractions and weak cry. The newborn's gestational history was preterm, small for gestational age, and preterm premature ruptured membrane for 14 hours...
May 8, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29720161/evaluation-of-a-training-program-of-hypertension-for-accredited-social-health-activists-asha-in-rural-india
#7
Marwa Abdel-All, Amanda Gay Thrift, Michaela Riddell, Kavumpurathu Raman Thankappan Thankappan, Gomathyamma Krishnakurup Mini, Clara K Chow, Pallab Kumar Maulik, Ajay Mahal, Rama Guggilla, Kartik Kalyanram, Kamakshi Kartik, Oduru Suresh, Roger George Evans, Brian Oldenburg, Nihal Thomas, Rohina Joshi
BACKGROUND: Hypertension is a major risk factor for cardiovascular disease, a leading cause of premature death and disability in India. Since access to health services is poor in rural India and Accredited Social Health Activists (ASHAs) are available throughout India for maternal and child health, a potential solution for improving hypertension control is by utilising this available workforce. We aimed to develop and implement a training package for ASHAs to identify and control hypertension in the community, and evaluate the effectiveness of the training program using the Kirkpatrick Evaluation Model...
May 2, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29717098/effect-of-transcutaneous-electrode-temperature-on-accuracy-and-precision-of-carbon-dioxide-and-oxygen-measurements-in-the-preterm-infants
#8
Jessica F Jakubowicz, Shasha Bai, David N Matlock, Michelle L Jones, Zhuopei Hu, Betty Proffitt, Sherry E Courtney
BACKGROUND: High electrode temperature during transcutaneous monitoring is associated with skin burns in extremely premature infants. We evaluated the accuracy and precision of CO2 and O2 measurements using lower transcutaneous electrode temperatures below 42°C. METHODS: We enrolled 20 neonates. Two transcutaneous monitors were placed simultaneously on each neonate, with one electrode maintained at 42°C and the other randomized to temperatures of 38, 39, 40, 41, and 42°C...
May 1, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29697542/salt-and-hypertension-what-do-we-know
#9
James J DiNicolantonio, James H O'Keefe
PURPOSE OF REVIEW: To evaluate the evidence for population-wide sodium restriction. RECENT FINDINGS: The recommendations for population-wide sodium restriction largely rely on one surrogate marker (blood pressure). However, recent evidence suggests that when looking beyond blood pressure (e.g. heart rate, aldosterone, renin, cholesterol, triglycerides, noradrenaline and adrenaline), the net effect of sodium restriction is likely harmful. Prospective studies support the notion that those consuming the lowest amounts of salt are at the highest risk of cardiovascular events and premature death...
April 24, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29695206/efficacy-and-safety-of-oral-paracetamol-versus-oral-ibuprofen-for-closure-of-patent-ductus-arteriosus-in-preterm-infants-a-randomized-controlled-trial
#10
Rania A El-Farrash, Mohammed S El Shimy, Abeer S El-Sakka, Manal G Ahmed, Dina G Abdel-Moez
OBJECTIVE: To evaluate the efficacy and safety of oral paracetamol versus oral ibuprofen in the treatment of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. STUDY DESIGN: An interventional randomized case-control study, registered in ClinicalTrials.gov ( NCT03265782 ), was conducted on 60 preterm infants with gestational age ≤ 34 weeks, postnatal age of 2-7 days and color Doppler echocardiographic evidence of hsPDA. Neonates were randomly assigned to two groups; 30 received oral ibuprofen and 30 received oral paracetamol...
April 25, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29679628/long-and-short-term-outcomes-of-gestational-diabetes-mellitus-gdm-among-south-asian-women-a-community-based-study
#11
REVIEW
B H Sudasinghe, C N Wijeyaratne, P S Ginige
AIMS: To quantify short and long-term outcomes of Gestational Diabetes Mellitus (GDM) among South Asians METHODS: Prospective cohort-study in Gampaha District, Sri Lanka following a community-prevalence study (WHO 1999 criteria). All women with GDM (exposed) and within sample non-GDM (non-exposed) were recruited. Data was gathered at selected intervals until one-year post-partum by interviewer-administered questionnaire, anthropometry, blood pressure, post-partum 75gOGTT and cholesterol...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29664499/ambulatory-blood-pressure-monitoring-in-school-children-with-a-history-of-extreme-prematurity
#12
Andrea Solís, Jaime Cerda, Claudia González
INTRODUCTION: Extremely premature children have a higher incidence of High Blood Pressure (HBP) and risk of renal damage due to decreased glomerular count with consequent hyperfiltration of the remnants. OBJECTIVES: To assess the prevalence of altered blood pressure values in outpatient measurement and ambulatory blood pressure monitoring (ABPM) in preterm infants ≤ 32 weeks and/ or ≤ 1,500 g birth weight between 5 and 7 years of age, as well as the presence of early renal damage markers...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29643701/higher-ventricular-premature-complex-burden-is-associated-with-lower-systolic-blood-pressure-response
#13
Jing-Wei Kang, Wei-Hsiang Yang, Jia-En Chi, Wei-Ta Chen
Background: Ventricular premature complexes (VPCs) with a burden higher than 10% to 20% of total daily heart beats can cause VPC-induced cardiomyopathy. The systolic blood pressure response (SBPR) is the difference between the SBP during maximal exercise and rest. A low SBPR was recently identified to be a marker of cardiomyopathy. The aim of this manuscript was to clarify the association between VPC burden and SBPR. Methods: From January to December 2015, all patients with a VPC burden larger than 240 beats/day on Holter recordings and treadmill exercise tests were enrolled...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29626346/propofol-for-implantable-cardioverter-defibrillator-implantation-in-patients-with-brugada-syndrome
#14
Hye-Mee Kwon, Sung-Hoon Kim, Se-Ung Park, Jin-Ho Rhim, Hee-Sun Park, Wook-Jong Kim, Gi-Byoung Nam
AIMS: Avoiding propofol in patients with Brugada syndrome has been suggested because of the theoretical risk of provoking ventricular arrhythmias, although propofol may be selected for conscious sedation during electrophysiological procedures in catheterization laboratories. This study aimed to document periprocedural electrocardiographic changes and adverse events in patients with Brugada syndrome undergoing implantable cardioverter defibrillator (ICD) implantation using propofol sedation...
April 6, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29623136/the-effects-of-continuous-positive-airway-pressure-on-premature-ventricular-contractions-and-ventricular-wall-stress-in-patients-with-heart-failure-and-sleep-apnea
#15
Sabri Seyis, Adnan Kazım Usalan, Ibrahim Rencuzogullari, Özge Kurmuş, Adil Can Gungen
Background: We aimed to investigate the effects of continuous positive airway pressure (CPAP) treatment on electrocardiography (ECG), premature ventricular contraction load on 24-hour Holter recordings, and implantable cardioverter defibrillator (ICD) shocks in patients with obstructive sleep apnea syndrome (OSAS) and heart failure. Methods: Patients with heart failure and ICD and patients with newly diagnosed OSAS were divided into two groups according to CPAP treatment...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29611320/high-fibroblast-growth-factor-23-concentrations-in-experimental-renal-failure-impair-calcium-handling-in-cardiomyocytes
#16
Melissa Verkaik, Maarten Oranje, Desiree Abdurrachim, Max Goebel, Zeineb Gam, Jeanine J Prompers, Michiel Helmes, Pieter M Ter Wee, Jolanda van der Velden, Diederik W Kuster, Marc G Vervloet, Etto C Eringa
The overwhelming majority of patients with chronic kidney disease (CKD) die prematurely before reaching end-stage renal disease, mainly due to cardiovascular causes, of which heart failure is the predominant clinical presentation. We hypothesized that CKD-induced increases of plasma FGF23 impair cardiac diastolic and systolic function. To test this, mice were subjected to 5/6 nephrectomy (5/6Nx) or were injected with FGF23 for seven consecutive days. Six weeks after surgery, plasma FGF23 was higher in 5/6Nx mice compared to sham mice (720 ± 31 vs...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29609555/long-term-effects-on-cardiovascular-risk-of-a-structured-multidisciplinary-lifestyle-program-in-clinical-practice
#17
Matthias Lidin, Mai-Lis Hellénius, Monica Rydell-Karlsson, Elin Ekblom-Bak
BACKGROUND: Cardiovascular disease is still the leading cause of premature death world-wide with factors like abdominal obesity, hypertension and dyslipidemia being central risk factors in the etiology. The aim of the present study was to investigate the effects on cardiovascular risk factors and cardiovascular risk after 6 months and 1 year, in individuals with increased cardiovascular risk enrolled in a lifestyle multidisciplinary program in a clinical setting. METHOD: Individuals with increased cardiovascular risk were referred from primary health care and hospitals to a program at an outpatient clinic at a department of cardiology...
April 2, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29606108/prevalence-and-risk-factors-of-retinopathy-of-prematurity-in-iran-a-systematic-review-and-meta-analysis
#18
Milad Azami, Zahra Jaafari, Shoboo Rahmati, Afsar Dastjani Farahani, Gholamreza Badfar
BACKGROUND: Retinopathy of prematurity (ROP) refers to the developmental disorder of the retina in premature infants and is one of the most serious and most dangerous complications in premature infants. The prevalence of ROP in Iran is different in various parts of Iran and its prevalence is reported to be 1-70% in different regions. This study aims to determine the prevalence and risk factors of ROP in Iran. METHODS: This review article was conducted based on the preferred reporting items for systematic review and meta-analysis (PRISMA) protocols...
April 2, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29604124/risk-factors-and-mortality-rate-in-premature-babies-with-acute-kidney-injury
#19
Ahmet Taner Elmas, Yılmaz Tabel, Ramazan Özdemir
BACKGROUND: Acute kidney injury (AKI) is a common morbidity in neonatal intensive care units and associated with poor outcome. This study aimed to determine the prevalence of AKI and provide a demographic data and risk factors associated with the mortality and morbidity. METHODS: This is a retrospective study included 105 premature babies. Diagnosis of AKI was based on neonatal KDIGO classification criteria. The babies were stratified into two groups according to AKI status during the hospitalization...
March 31, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29596534/the-characteristics-of-premature-infants-with-transient-corneal-haze
#20
Yu-Hung Lai, Hsiu-Lin Chen, San-Nan Yang, Shun-Jen Chang, Lea-Yea Chuang, Wen-Chuan Wu
BACKGROUND: The etiology of transient corneal haze in premature infants is not known and how it relates to clinical outcomes in premature infants is not clear. OBJECTIVES: To study associated factors of transient corneal haze in premature infants. METHODS: We performed a retrospective study of 261 premature infants from retinopathy of prematurity (ROP) screening in the neonatal intensive care unit at a tertiary referral hospital. Characteristics of premature infants with and without corneal haze were analyzed by correlation tests, Chi-square tests, and logistic regressions were used for statistical analyses...
2018: PloS One
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