keyword
https://read.qxmd.com/read/38524772/cost-effectiveness-analysis-for-commonly-used-human-cell-and-tissue-products-in-the-management-of-diabetic-foot-ulcers
#1
JOURNAL ARTICLE
Leo M Nherera, Jaideep Banerjee
BACKGROUND AND AIMS: This study considers the cost-effectiveness of commonly used cellular, acellular, and matrix‑like products (CAMPs) of human origin also known as human cell and tissue products (HCT/Ps) in the management of diabetic foot ulcers. METHODS: We developed a 1-year economic model assessing six CAMPs [cryopreserved placental membrane with viable cells (vCPM), bioengineered bilayered living cellular construct (BLCC), human fibroblast dermal substitute (hFDS), dehydrated human amnion chorion membrane (dHACM), hypothermically stored amniotic membrane (HSAM) and human amnion membrane allograft (HAMA) which had randomized controlled trial evidence compared with standard of care (SoC)...
March 2024: Health Science Reports
https://read.qxmd.com/read/38502450/dissociation-of-placental-tissues-for-single-cell-techniques
#2
JOURNAL ARTICLE
Valeria Garcia-Flores, Derek Miller, Jose Galaz, Nardhy Gomez-Lopez
The dissociation of whole tissue into single-cell suspensions is a critical step for techniques focused on profiling of individual cells. Here, we describe a protocol for the preparation of high-quality single-cell suspensions from human placental tissues: the basal plate (BP), placental villi (PV), and chorioamniotic membranes (CAM). This protocol also provides guidance for the cryopreservation and recovery of single-cell suspensions for later use. The methods described here have been demonstrated to be suitable for downstream single-cell applications, such as single-cell RNA-sequencing, that require viable, high-quality cell suspensions...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38084271/twin-pregnancy-live-fetus-with-complete-hydatidiform-molar-a-case-report
#3
Georges Yared, Fatima Dahrouj, Charlotte El Hajjar, Khaled Habib, Mohammad El Jawad El Kazwini, Kariman Ghazal
Gestational trophoblastic disease encompasses a range of lesions, each culminating in varied clinical manifestations. Among these, the simultaneous occurrence of molar changes within the placenta and a viable fetus remains a particularly elusive and challenging presentation, posing intricate dilemmas for obstetricians. In this article, we delineate a distinct case involving a 21-year-old woman with a history of consanguineous marriage. She was referred from Médecins Sans Frontières to the Rafic Hariri University Hospital during her 19th week of gestation...
2023: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38029017/advancements-in-cell-based-therapies-for-the-treatment-of-pressure-injuries-a-systematic-review-of-interventional-studies
#4
REVIEW
Alianda Camesi, Reto Wettstein, Ezra Valido, Nicole Nyfeler, Stevan Stojic, Marija Glisic, Jivko Stoyanov, Alessandro Bertolo
The high recurrence and complications associated with severe pressure injuries (PI) necessitate the exploration of advanced treatments, such as cell-based therapies, to facilitate wound healing. Such techniques harness the ability of different cell types to promote angiogenesis, re-epithelialization of the skin, and tissue regeneration. This systematic review explores the efficacy of cell-based therapies and tissue engineering in treating deep PI. We searched for interventional studies using cells in the treatment of PI in adults in four online libraries (PubMed, Embase, Ovid Medline, and Cochrane; latest search 10th June 2023)...
2023: Journal of Tissue Engineering
https://read.qxmd.com/read/37942849/harnessing-human-placental-membrane-derived-bioinks-characterization-and-applications-in-bioprinting-and-vasculogenesis
#5
JOURNAL ARTICLE
Léo Comperat, Lise Chagot, Sarah Massot, Marie-Laure Stachowicz, Nathalie Dusserre, Chantal Médina, Théo Desigaux, Jean-William Dupuy, Jean-Christophe Fricain, Hugo Oliveira
Bioprinting applications in the clinical field generate great interest, but developing suitable biomaterial inks for medical settings is a challenge. Placental tissues offer a promising solution due to their abundance, stability, and status as medical waste. They contain basement membrane components, have a clinical history, and support angiogenesis. This study formulated bioinks from two placental tissues, amnion (AM) and chorion (CHO), and compared their unique extracellular matrix (ECM) and growth factor compositions...
November 9, 2023: Advanced Healthcare Materials
https://read.qxmd.com/read/37811353/a-prospective-multicenter-study-of-a-weekly-application-regimen-of-viable-human-amnion-membrane-allograft-in-the-management-of-nonhealing-diabetic-foot-ulcers
#6
JOURNAL ARTICLE
Robert D Galiano, Dennis P Orgill, David G Armstrong, Paul M Glat, Marissa J Carter, Charles M Zelen
BACKGROUND: Diabetic foot ulcers (DFUs) pose a significant clinical challenge for providers and patients, and often precede devastating complications such as infection, hospitalization, and amputation. Therefore, advanced treatment options are needed to facilitate the healing of chronic DFUs and improve outcomes in this high-risk population. Cryopreserved viable human amnion membrane allograft (vHAMA) has shown great promise in the treatment of recalcitrant DFUs as a supplement to standard of care (SOC)...
October 2023: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/37331462/pregnancy-outcomes-with-a-copper-380%C3%A2-mm-2-intrauterine-device-in-place-a-retrospective-cohort-study-in-turkey-2011-2021
#7
JOURNAL ARTICLE
Sultan Seren Karakuş, Resul Karakuş, Emine Eda Akalın, Münip Akalın
OBJECTIVES: To investigate pregnancy outcomes in patients with pregnancies with a copper 380 mm2 intrauterine device (IUD) in situ at conception. STUDY DESIGN: In this retrospective study, we identified patients with pregnancies with a copper 380 mm2 IUD between 2011 and 2021 from the electronic health record system. According to their initial diagnosis, we classified the patients as having nonviable intrauterine pregnancies (IUPs), viable IUPs, or ectopic pregnancies...
September 2023: Contraception
https://read.qxmd.com/read/37330009/pregnancy-with-retained-intrauterine-device-national-level-assessment-of-characteristics-and-outcomes
#8
JOURNAL ARTICLE
Viraj R Panchal, Alesandra R Rau, Rachel S Mandelbaum, Caroline J Violette, Chelsy A Harris, Doerthe Brueggmann, Shinya Matsuzaki, Joseph G Ouzounian, Koji Matsuo
BACKGROUND: Although intrauterine devices provide effective contraceptive protection, unintentional pregnancy can occur. Previous studies have shown that a retained intrauterine device during pregnancy is associated with adverse pregnancy outcomes but there is a paucity of nationwide data and analysis. OBJECTIVE: This study aimed to describe characteristics and outcomes of pregnancies with a retained intrauterine device. STUDY DESIGN: This serial cross-sectional study used data from the Healthcare Cost and Utilization Project's National Inpatient Sample...
September 2023: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/36799879/the-use-of-a-dehydrated-complete-human-placental-membrane-allograft-for-mohs-surgical-defects-of-the-nose
#9
JOURNAL ARTICLE
Kelly M Wilmas, Jigar Patel, Sirunya Silapunt, Hung Q Doan, Michael R Migden
BACKGROUND: Repair options for Mohs surgical defects include primary closure, flap or graft, or healing by second intention. These options may not be optimal in all cases. A dehydrated complete human placental membrane (dCHPM) allograft may serve as an alternative repair option. OBJECTIVE: To assess the aesthetic and functional outcomes of an alternative repair technique for Mohs surgical defects of the nose. METHODS: Twenty patients with Mohs surgical defects of the nose repaired with a dCHPM allograft were retrospectively identified...
February 13, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/36476252/dietary-supplementation-with-0-4-l-arginine-between-days-14-and-30-of-gestation-enhances-no-and-polyamine-syntheses-and-water-transport-in-porcine-placentae
#10
JOURNAL ARTICLE
Cassandra M Herring, Fuller W Bazer, Gregory A Johnson, Heewon Seo, Shengdi Hu, Mohammed Elmetwally, Wenliang He, Daniel B Long, Guoyao Wu
BACKGROUND: Most embryonic loss in pigs occurs before d 30 of gestation. Dietary supplementation with L-arginine (Arg) during early gestation can enhance the survival and development of conceptuses (embryo/fetus and its extra-embryonic membranes) in gilts. However, the underlying mechanisms remain largely unknown. METHODS: Between d 14 and 30 of gestation, each gilt was fed daily 2 kg of a corn- and soybean-meal based diet (12% crude protein) supplemented with either 0...
December 8, 2022: Journal of Animal Science and Biotechnology
https://read.qxmd.com/read/35461182/lactococcus-lactis-cremoris-intra-uterine-infection-about-an-uncommon-case-report
#11
JOURNAL ARTICLE
Aziz Slaoui, Imane Benmouna, Najia Zeraidi, Amina Lakhdar, Aicha Kharbach, Aziz Baydada
BACKGROUND: When intra-uterine infection (IUI) is suspected or confirmed, intravenous antibiotic therapy providing coverage against common organisms (S. agalactiae and E. coli) is recommended to be administered immediately in order to reduce the risk of maternal and neonatal infectious complications. Nevertheless, it happens that some infections are due to uncommon microorganisms that do not respond to probabilistic treatment. Therefore, samples with bacteriological examination remain systematic...
May 2022: International Journal of Surgery Case Reports
https://read.qxmd.com/read/35429809/opa-interacting-protein-5-promotes-proliferation-and-migration-of-trophoblast-cells-via-activating-stat3-pathway
#12
JOURNAL ARTICLE
Hui Xu, Jing Wang, Jiuying Liu, Juan Huang
Missed abortion, one of the leading causes of maternal and perinatal mortality, is associated with impaired trophoblast function. Opa interacting protein 5 (OIP5) interacts with outer membrane proteins, Opa, to play an important role in mitosis and tumorigenesis. The role of OIP5 in missed abortion was investigated in this study. Firstly, the expression of OIP5 in villous samples from patients with missed abortion was compared with women with normal pregnancies. Result showed that OIP5 was down-regulated in the placental villi from patients with missed abortion...
June 2022: Reproductive Biology
https://read.qxmd.com/read/35367779/porcine-reproductive-and-respiratory-syndrome-virus-induces-tight-junction-barrier-dysfunction-and-cell-death-in-porcine-glandular-endometrial-epithelial-cells
#13
JOURNAL ARTICLE
Dran Rukarcheep, Muttarin Lothong, Suphot Wattanaphansak, Chatsri Deachapunya, Sutthasinee Poonyachoti
Reproductive failure caused by porcine reproductive and respiratory syndrome virus (PRRSV) is characterized by embryonic death and weak-born piglets and is associated with placental cell apoptosis and impairment of endometrial integrity. Here, we aimed to determine whether endometrial epithelial barrier function and viability were altered following PRRSV type 1 or type 2 infection. PRRSV inoculation was examined at the apical or basolateral side of porcine glandular endometrial epithelial cell cultures isolated from 4- to 6-month-old PRRSV-free herd gilts (n = 7 pigs)...
June 2022: Theriogenology
https://read.qxmd.com/read/34882575/a-retrospective-analysis-of-clinical-use-and-outcomes-using-viable-placental-membrane-allografts-in-chronic-wounds
#14
JOURNAL ARTICLE
Laura Swoboda
INTRODUCTION: Viable placental membrane (vPM) has been shown to decrease time to healing, adverse wound events, and wound-related infections. Wound research exclusion criteria commonly exclude wound types other than diabetic foot ulcers and venous leg ulcers (VLUs), comorbidities including peripheral arterial disease (PAD) and uncontrolled diabetes mellitus (DM), and wounds with exposed bone or tendon. OBJECTIVE: This retrospective research study evaluated the clinical use and outcomes of the vPM with living mesenchymal stem cells used in chronic wound management in the community hospital outpatient department setting with the goal of comparing real-world use and outcomes of the product with use and outcomes described in the chronic wound literature...
December 2021: Wounds: a Compendium of Clinical Research and Practice
https://read.qxmd.com/read/34592649/trauma-and-pregnancy-is-flow-cytometry-detection-and-quantification-of-fetal-red-blood-cells-useful
#15
JOURNAL ARTICLE
Misgav Rottenstreich, Reut Meir, Itamar Glick, Heli Alexandroni, Alon D Schwarz, Ellen Broide, Sorina Grisaru-Granovsky, Hen Y Sela
OBJECTIVE: To assess whether positive flow cytometry quantification of fetal red blood cells is associated with adverse maternal and neonatal outcomes in cases of mild trauma during pregnancy. STUDY DESIGN: A retrospective database study was conducted at a single tertiary center between 2013 and 2019. All pregnant women with viable gestation involved in trauma who underwent flow cytometry quantification of fetal red blood cells were included in the study. Flow cytometry was considered positive (≥0...
November 2021: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/34172762/genes-and-pathways-associated-with-pregnancy-loss-in-dairy-cattle
#16
JOURNAL ARTICLE
Anil Sigdel, Rafael S Bisinotto, Francisco Peñagaricano
Pregnancy loss directly impairs reproductive performance in dairy cattle. Here, we investigated genetic factors associated with pregnancy loss following detection of a viable embryo around 42 days of gestation. The objectives of this study were to perform whole-genome scans and subsequent gene-set analyses for identifying candidate genes, functional gene-sets and gene signaling pathways implicated in pregnancy loss in US Holstein cows. Data consisted of about 58,000 pregnancy/abortion records distributed over nulliparous, primiparous, and multiparous cows...
June 25, 2021: Scientific Reports
https://read.qxmd.com/read/33591930/cryopreserved-placental-membranes-containing-viable-cells-result-in-high-closure-rate-of-nonhealing-upper-and-lower-extremity-wounds-of-non-diabetic-and-non-venous-pathophysiology
#17
JOURNAL ARTICLE
Eric L Johnson, Molly Saunders, Tanushree Thote, Alla Danilkovitch
INTRODUCTION: Higher closure rates for chronic diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) have been reported for placental products adjunct to standard of care (SOC) vs SOC alone; however, data for other types of wounds are limited. OBJECTIVE: This study aimed to evaluate the clinical outcomes of amnion-derived and chorion-derived cryopreserved placental membranes containing viable cells (vCPM) in the treatment of nonhealing upper-extremity and lower-extremity wounds of nondiabetic and nonvenous pathophysiology...
February 2021: Wounds: a Compendium of Clinical Research and Practice
https://read.qxmd.com/read/32819193/placental-mitochondria-therapy-for-cerebral-ischemia-reperfusion-injury-in-mice
#18
JOURNAL ARTICLE
Yoshihiko Nakamura, Eng H Lo, Kazuhide Hayakawa
BACKGROUND AND PURPOSE: There is an urgent need to develop adjunct therapies that can be added onto reperfusion for acute ischemic stroke. Recently, mitochondrial transplantation has emerged as a promising therapeutic approach for boosting brain tissue protection. In this proof-of-concept study, we investigate the feasibility of using placenta as a source for mitochondrial transplantation in a mouse model of transient focal cerebral ischemia-reperfusion. METHODS: Mitochondria-enriched fractions were isolated from cryopreserved mouse placenta...
October 2020: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/32776951/evidence-for-contamination-as-the-origin-for-bacteria-found-in-human-placenta-rather-than-a-microbiota
#19
JOURNAL ARTICLE
Rémi Gschwind, Thierry Fournier, Sean Kennedy, Vassilis Tsatsaris, Anne-Gaël Cordier, Frédéric Barbut, Marie-José Butel, Sandra Wydau-Dematteis
Until recently the in utero environment of pregnant women was considered sterile. Recent high-sensitivity molecular techniques and high-throughput sequencing lead to some evidence for a low-biomass microbiome associated with the healthy placenta. Other studies failed to reveal evidence for a consistent presence of bacteria using either culture or molecular based techniques. Comparing conflicting "placental microbiome" studies is complicated by the use of varied and inconsistent protocols. Given this situation, we undertook an evaluation of the in utero environment sterility using several controlled methods, in the same study, to evaluate the presence or absence of bacteria and to explain contradictions present in the literature...
2020: PloS One
https://read.qxmd.com/read/32274052/management-of-a-complex-scalp-defect-with-cryopreserved-placental-membrane-containing-viable-cells-resulted-in-rapid-wound-closure
#20
Tim A Fife, Tanushree Thote, Molly C Saunders
Reconstructive methods are most commonly used to treat scalp defects. However, patients with complex defects are often not good candidates for surgical procedures due to the severity of the wound, advanced patient age, and multiple comorbidities. In these instances, alternative nonsurgical advanced therapies should be considered.
April 2020: Clinical Case Reports
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