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Viable placental membrane

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https://www.readbyqxmd.com/read/28403020/understanding-the-impact-of-preservation-methods-on-the-integrity-and-functionality-of-placental-allografts
#1
Amy Johnson, Alexandra Gyurdieva, Sandeep Dhall, Alla Danilkovitch, Yi Duan-Arnold
INTRODUCTION: Human placental membranes (hPMs) have a long history in treating burns and wounds. The composition of hPMs includes structural matrix, growth factors, and neonatal cells, all of which contribute to their regenerative potential. However, most hPM products are devitalized after dehydration and irradiation. We compared the functionality of single-layer viable cryopreserved human amniotic membrane (vCHAM) with multilayer devitalized dehydrated human amnion/chorion membrane (dHACM) in wound-relevant models to determine the effect of different processing methods on hPMs...
April 12, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28293501/management-of-a-complex-excoriation-disorder-induced-wound-with-a-viable-cryopreserved-placental-membrane
#2
Michael A Bain, Jennifer Vincent
Excoriation disorder (ED), also known as dermatotillomania, is a condition characterized by repeated "skin picking" that leads to the formation of skin lesions. Because of the similarity of its symptoms to obsessive compulsive disorder, ED is classified as a subcategory of obsessive compulsive disorder by Diagnostic and Statistical Manual of Mental Disorders Fifth Edition. Although the majority of the self-inflicted wounds are not clinically significant, many wounds lead to social and occupational dysfunction by becoming infected, chronic, and life threatening...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27997744/a-comparative-outcomes-analysis-evaluating-clinical-effectiveness-in-two-different-human-placental-membrane-products-for-wound-management
#3
Eric L Johnson, James T Marshall, Georgina M Michael
Advances in tissue preservation have led to the commercialization of human placental membranes for the purposes of wound management with each product being characterized by different compositions and properties. The a priori specification of the research question in this investigator-initiated study focused on the clinical outcomes in two nonrandomized, however statistically equal and homogenous patient cohorts receiving either a viable intact cryopreserved human placental membrane (vCPM) or a dehydrated human amnion/chorion membrane (dHACM), for the management of wounds at a single center...
December 20, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27965171/human-placenta-hydrogel-reduces-scarring-in-a-rat-model-of-cardiac-ischemia-and-enhances-cardiomyocyte-and-stem-cell-cultures
#4
Michael P Francis, Erick Breathwaite, Anna A Bulysheva, Frency Varghese, Rudy U Rodriguez, Sucharita Dutta, Iurii Semenov, Rebecca Ogle, Alexander Huber, Alexandra-Madelaine Tichy, Silvia Chen, Christian Zemlin
INTRODUCTION: Xenogeneic extracellular matrix (ECM) hydrogels have shown promise in remediating cardiac ischemia damage in animal models, yet analogous human ECM hydrogels have not been well development. An original human placenta-derived hydrogel (hpECM) preparation was thus generated for assessment in cardiomyocyte cell culture and therapeutic cardiac injection applications. METHODS AND RESULTS: Hybrid orbitrap-quadrupole mass spectrometry and ELISAs showed hpECM to be rich in collagens, basement membrane proteins, and regenerative growth factors (e...
April 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27852883/wound-closure-in-smoking-peripheral-arterial-disease-patients-with-treatment-refractory-ulcerations-a-12-month-follow-up-case-series
#5
Jonathan Smedley, Georgina M Michael, Yeabsera G Tamire
Despite ongoing smoking cessation efforts and optimized perfusion, failed wound closure in the presence of peripheral arterial disease (PAD) and diabetes are common. A clinical effectiveness review was conducted in actively smoking diabetic patients diagnosed with PAD, treated with serial applications of a viable intact cryopreserved human placental membrane (vCPM) (Grafix, Osiris Therapeutics Inc, Columbia, MD) for recalcitrant lower extremity ulcerations (n = 6). More than half of the patients were not candidates for revascularization...
November 15, 2016: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/27847669/novel-approach-for-enterocutaneous-fistula-treatment-with-the-use-of-viable-cryopreserved-placental-membrane
#6
Frederick Nichols, Aaron Overly
Enterocutaneous fistulas (ECF) are a difficult and costly surgical complication to manage. The standard treatment of nil per os (NPO) and total paraenteral nutrition (TPN) is not well tolerated by patients. TPN is also known for complications associated with long term central venous catheterization and for high cost of prolonged hospital stay. We present two low output ECF cases successfully treated with viable cryopreserved placental membrane (vCPM) placed into the fistula tracts. One patient is a 59-year-old male with a low output ECF from a jejunostomy tube site four weeks after the surgery...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27681807/viable-intact-cryopreserved-human-placental-membrane-for-a-non-surgical-approach-to-closure-in-complex-wounds
#7
K Suzuki, G Michael, Y Tamire
OBJECTIVE: Advances in wound treatment have yielded successful approaches to complex wound closure through plastic surgery or other staged surgical methods. However, not all patients or wounds are candidates for such increasingly rigorous levels of interventions. The exploration of non-surgical treatment options that promote anatomical and functional tissue replacement on an outpatient basis without donor site morbidity is necessary to maximise opportunities for patient mobility and rehabilitation...
October 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27649406/comparing-the-efficacy-of-viable-cryopreserved-placental-membrane-for-the-treatment-of-wounds-of-diverse-etiologies
#8
Derek S Anselmo, Marc Karpo, Ebony Love, Tracey Vlahovic
INTRODUCTION AND OBJECTIVES: The benefits of using amniotic tissue in skin regeneration are well documented. Today, cryopreservation technology allows for better availability and maintenance of mesenchymal stem cells. This is of particular interest in treating the diabetic foot ulcer as this population has fewer mesenchymal stem cells. The objective of this case series investigation was to compare the efficacy of cryopreserved human amniotic stem cells in treating foot wounds of different etiologies...
September 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27489115/a-prospective-multicentre-open-label-single-arm-clinical-trial-for-treatment-of-chronic-complex-diabetic-foot-wounds-with-exposed-tendon-and-or-bone-positive-clinical-outcomes-of-viable-cryopreserved-human-placental-membrane
#9
Robert G Frykberg, Gary W Gibbons, Jodi L Walters, Dane K Wukich, Farrell C Milstein
Complex diabetic foot ulcers (DFUs) with exposed tendon or bone remain a challenge. They are more susceptible to complications such as infection and amputation and require treatments that promote rapid development of granulation tissue and, ultimately, reepithelialisation. The clinical effectiveness of viable cryopreserved human placental membrane (vCHPM) for DFUs has been established in a level 1 trial. However, complex wounds with exposed deeper structures are typically excluded from randomised controlled clinical trials despite being common in clinical practice...
August 3, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27385010/delineation-of-proteolytic-and-non-proteolytic-functions-of-the-membrane-anchored-serine-protease-prostasin
#10
Roman Szabo, Taliya Lantsman, Diane E Peters, Thomas H Bugge
The membrane-anchored serine proteases prostasin (PRSS8) and matriptase (ST14) initiate a cell surface proteolytic pathway essential for epithelial function. Mice expressing only catalytically inactive prostasin are viable, unlike prostasin null mice, indicating that at least some prostasin functions are non-proteolytic. Here we used knock-in mice expressing catalytically inactive prostasin (Prss8(Ki/Ki)) to show that the physiological and pathological functions of prostasin vary in their dependence on its catalytic activity...
August 1, 2016: Development
https://www.readbyqxmd.com/read/27375911/placenta-increta-complicating-persistent-cesarean-scar-ectopic-pregnancy-following-failed-excision-with-subsequent-preterm-cesarean-hysterectomy
#11
M F Malik, L R Hoyos, J Rodriguez-Kovacs, J Gillum, S C Johnson
Introduction. Cesarean scar pregnancies (CSPs) are one of the rarest forms of ectopic pregnancy. Given their rarity, there is lack of consensus regarding the management and natural course of CSPs. Case. A 37-year-old G10 P3063 female with a history of two prior cesarean deliveries was diagnosed with her second CSP at 6 weeks and 5 days in her tenth pregnancy. The patient underwent vertical hysterotomy, excision of a gestational sac implanted in the cesarean sac, and bilateral salpingectomy via a laparotomy incision...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26334607/guidelines-for-the-management-of-a-pregnant-trauma-patient
#12
Venu Jain, Radha Chari, Sharon Maslovitz, Dan Farine, Emmanuel Bujold, Robert Gagnon, Melanie Basso, Hayley Bos, Richard Brown, Stephanie Cooper, Katy Gouin, N Lynne McLeod, Savas Menticoglou, William Mundle, Christy Pylypjuk, Anne Roggensack, Frank Sanderson
OBJECTIVE: Physical trauma affects 1 in 12 pregnant women and has a major impact on maternal mortality and morbidity and on pregnancy outcome. A multidisciplinary approach is warranted to optimize outcome for both the mother and her fetus. The aim of this document is to provide the obstetric care provider with an evidence-based systematic approach to the pregnant trauma patient. OUTCOMES: Significant health and economic outcomes considered in comparing alternative practices...
June 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/26260700/the-rat-placental-renin-angiotensin-system-a-gestational-gene-expression-study
#13
Kanchan Vaswani, Hsiu-Wen Chan, Pali Verma, Marloes Dekker Nitert, Hassendrini N Peiris, Ryan J Wood-Bradley, James A Armitage, Gregory E Rice, Murray D Mitchell
BACKGROUND: The placenta is an essential organ that provides nutrients and oxygen to the developing fetus and removes toxic waste products from the fetal circulation. Maintaining placental blood osmotic pressure and blood flow is crucial for viable offspring. The renin-angiotensin system (RAS) in the placenta is a key player in the regulation of maternal-fetal blood flow during pregnancy. Therefore, the aim of this study was to determine if RAS genes are differentially expressed in mid to late gestation in rat placenta...
2015: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/26229539/in-vitro-differentiation-potential-of-human-placenta-derived-cells-into-skin-cells
#14
Ruhma Mahmood, Mahmood S Choudhery, Azra Mehmood, Shaheen N Khan, Sheikh Riazuddin
Skin autografting is the most viable and aesthetic technique for treatment of extensive burns; however, this practice has potential limitations. Harvesting cells from neonatal sources (such as placental tissue) is a simple, inexpensive, and noninvasive procedure. In the current study authors sought to evaluate in vitro potential of human placenta derived stem cells to develop into skin-like cells. After extensive washing, amniotic membrane and umbilical cord tissue were separated to harvest amniotic epithelial cells (AECs) and umbilical cord mesenchymal stem cells (UC-MSCs), respectively...
2015: Stem Cells International
https://www.readbyqxmd.com/read/24936442/genetically-induced-oxidative-stress-in-mice-causes-thrombocytosis-splenomegaly-and-placental-angiodysplasia-that-leads-to-recurrent-abortion
#15
Takamasa Ishii, Masaki Miyazawa, Yumi Takanashi, Maya Tanigawa, Kayo Yasuda, Hiromi Onouchi, Noboru Kawabe, Junji Mitsushita, Phil S Hartman, Naoaki Ishii
Historical data in the 1950s suggests that 7%, 11%, 33%, and 87% of couples were infertile by ages 30, 35, 40 and 45, respectively. Up to 22.3% of infertile couples have unexplained infertility. Oxidative stress is associated with male and female infertility. However, there is insufficient evidence relating to the influence of oxidative stress on the maintenance of a viable pregnancy, including pregnancy complications and fetal development. Recently, we have established Tet-mev-1 conditional transgenic mice, which can express the doxycycline-induced mutant SDHC(V69E) transgene and experience mitochondrial respiratory chain dysfunction leading to intracellular oxidative stress...
2014: Redox Biology
https://www.readbyqxmd.com/read/24467708/the-term-basal-plate-of-the-human-placenta-as-a-source-of-functional-extravillous-trophoblast-cells
#16
Alexandre U Borbely, Silvana Sandri, Isabella R Fernandes, Karen M Prado, Elaine C Cardoso, Simone Correa-Silva, Renata Albuquerque, Martin Knöfler, Patricia Beltrão-Braga, Ana Campa, Estela Bevilacqua
BACKGROUND: Extravillous trophoblast (EVT) cells are of pivotal importance in human embryo implantation and homeostasis of the maternal fetal interface. Invasion of the endometrium by EVT contributes to placental anchorage, spiral artery remodeling, immunological defense, tolerogenic responses, and several collaborative cross talks involved in establishing and maintaining a successful pregnancy. We report here an improved protocol for the isolation of fully differentiated EVT cells from the basal plate of the human term placenta...
2014: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/23764139/in-vitro-simulation-of-placental-transport-part-i-biological-model-of-the-placental-barrier
#17
R Levkovitz, U Zaretsky, Z Gordon, A J Jaffa, D Elad
INTRODUCTION: The placental barrier (PB) is the thin biological membrane made of endothelial cells (EC), trophoblast cells (TC) and basal membrane that separates between maternal and fetal blood circulations within the placenta and facilitates feto-maternal transport characteristics, which are not completely understood. METHODS: An in vitro biological model of the PB model was co-cultured of human TC (HTR8) and human umbilical vein EC (HUVEC) on both sides of a denuded amniotic membrane (AM) using custom designed wells...
August 2013: Placenta
https://www.readbyqxmd.com/read/23528884/extracorporeal-delivery-of-raav-with-metabolic-exchange-and-oxygenation
#18
Scott Bieber, Jeffrey B Halldorson, Eric Finn, Suhail Ahmad, Jeffrey S Chamberlain, Guy L Odom
Over the past decade much progress has been made towards the treatment of disease with recombinant adeno-associated viral vectors, ranging from cancer to muscular dystrophies, and autoimmune diseases to cystic fibrosis. Given inherent challenges of vector delivery we developed a system incorporating commercially available dialysis equipment. This concept was evaluated in vitro utilizing rAAV expressing the reporter gene human placental alkaline phosphatase. A number of pre-circulating conditions were assessed...
2013: Scientific Reports
https://www.readbyqxmd.com/read/23209569/mtrop1-epcam-knockout-mice-develop-congenital-tufting-enteropathy-through-dysregulation-of-intestinal-e-cadherin-%C3%AE-catenin
#19
Emanuela Guerra, Rossano Lattanzio, Rossana La Sorda, Francesca Dini, Gian Mario Tiboni, Mauro Piantelli, Saverio Alberti
Congenital tufting enteropathy (CTE) is a life-threatening hereditary disease that is characterized by enteric mucosa tufting degeneration and early onset, severe diarrhea. Loss-of-function mutations of the human EPCAM gene (TROP1, TACSTD1) have been indicated as the cause of CTE. However, loss of mTrop1/Epcam in mice appeared to lead to death in utero, due to placental malformation. This and indications of residual Trop-1/EpCAM expression in cases of CTE cast doubt on the role of mTrop1/Epcam in this disease...
2012: PloS One
https://www.readbyqxmd.com/read/22348351/gestational-weight-loss-has-adverse-effects-on-placental-development
#20
Junichi Hasegawa, Masamitsu Nakamura, Shoko Hamada, Ayumi Okuyama, Ryu Matsuoka, Kiyotake Ichizuka, Akihiko Sekizawa, Takashi Okai
OBJECTIVE: To clarify whether mothers with gestational weight loss (GWL) were likely to have adverse effects on the placenta. STUDY DESIGN: Subjects who delivered viable singleton infants after 24 weeks of gestation were enrolled. A retrospective analysis to evaluate cases of GWL in association with the findings of the placenta and amniotic membrane after delivery was conducted. After consideration of confounders, a case-control study with matched pairs (1:2) was performed...
October 2012: Journal of Maternal-fetal & Neonatal Medicine
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