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Diabetic Foot Ulcer Graft

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https://www.readbyqxmd.com/read/27826487/aseptically-processed-placental-membrane-improves-healing-of-diabetic-foot-ulcerations-prospective-randomized-clinical-trial
#1
Lawrence A DiDomenico, Dennis P Orgill, Robert D Galiano, Thomas E Serena, Marissa J Carter, Jarrod P Kaufman, Nathan J Young, Charles M Zelen
BACKGROUND: Allogeneic grafts derived from amnion/chorion are known to be efficacious in healing chronic diabetic foot ulcerations (DFUs). The goal of this study was to compare aseptically processed dehydrated human amnion and chorion allograft (dHACA) versus standard of care (SOC) in facilitating wound closure in nonhealing DFUs. METHODS: Patients with DFUs treated with SOC (off-loading, appropriate debridement, and moist wound care) after a 2-week screening period were randomized to either SOC or wound-size-specific dHACA (AmnioBand, Musculoskeletal Transplant Foundation, Edison, N...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27694302/combination-of-open-subtotal-calcanectomy-and-stabilization-with-external-fixation-as-limb-salvage-procedure-in-hindfoot-infected-diabetic-foot-ulcers
#2
Luca Dalla Paola, Anna Carone, Giulio Boscarino, Giuseppe Scavone, Lucian Vasilache
Diabetic hindfoot ulcers, complicated by osteomyelitis, are associated with a high risk of major amputation. Partial calcanectomy, preceded by an effective management of the infection and of the eventual peripheral artery disease, can be considered as valid therapeutic option. We have evaluated a therapeutic protocol for diabetic hindfoot ulcers complicated by osteomyelitis, which, besides an adequate surgical debridement, considers a reconstructive pathway assisted by the positioning of a circular external fixator...
September 29, 2016: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/27662892/single-stage-bipedicle-local-tissue-transfer-and-skin-graft-for-achilles-tendon-surgery-wound-complications
#3
Travis J Dekker, Yash Avashia, Suhail K Mithani, Andrew P Matson, Alexander J Lampley, Samuel B Adams
: Introduction Achilles tendon and posterior heel wound complications are difficult to treat. These typically require soft tissue coverage via microvascular free tissue transfer at a tertiary referral center. Here, we describe coverage of a series of posterior heel and Achilles wounds via simple, local tissue transfer, called a bipedicle fasciocutaneous flap. This flap can be performed by an orthopaedic foot and ankle surgeon, without resources of tertiary/specialized care or microvascular support...
September 23, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27649406/comparing-the-efficacy-of-viable-cryopreserved-placental-membrane-for-the-treatment-of-wounds-of-diverse-etiologies
#4
Derek S Anselmo, Marc Karpo, Ebony Love, Tracey Vlahovic
INTRODUCTION AND OBJECTIVES: The benefits of using amniotic tissue in skin regeneration are well documented. Today, cryopreservation technology allows for better availability and maintenance of mesenchymal stem cells. This is of particular interest in treating the diabetic foot ulcer as this population has fewer mesenchymal stem cells. The objective of this case series investigation was to compare the efficacy of cryopreserved human amniotic stem cells in treating foot wounds of different etiologies...
September 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27562158/-application-of-percutaneous-transluminal-angioplasty-in-the-surgical-treatment-of-patients-with-diabetic-feet
#5
Y Gao, Z J Cui, X Shi, P F Guo, Q N Meng, G Y Yang, R Q Yang
OBJECTIVE: To explore the application of percutaneous transluminal angioplasty (PTA) in the surgical treatment of patients with diabetic feet. METHODS: The clinical data of 83 patients with diabetic feet, 95 limbs (95 wounds) in total, hospitalized in our unit from September 2011 to September 2014, conforming to the study criteria, were retrospectively analyzed. Patients were divided into conventional treatment group (CT, n=43, 51 wounds) and PTA group (n=40, 44 wounds) according to whether receiving PTA treatment or not...
August 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27536489/plantar-fat-grafting-and-tendon-balancing-for-the-diabetic-foot-ulcer-in-remission
#6
Cynthia A Luu, Ethan Larson, Timothy M Rankin, Jennifer L Pappalardo, Marvin J Slepian, David G Armstrong
We report on the use of free fat grafting as a means of redistributing normal and shear stress after healing of plantar diabetic foot wounds. Although fat augmentation (lipofilling) has been described previously as an approach to supplement defects and prevent atrophy, including use as an adjunct to wound healing and to mitigate pain in the foot, we are unaware of any reports in the medical literature that have described its use in the high-risk diabetic foot in remission. An active 37-year-old man with type 2 diabetes and neuropathy presented with gangrene of his fifth ray, which was amputated...
July 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27458594/spontaneous-calcaneal-fracture-in-patients-with-diabetic-foot-ulcer-four-cases-report-and-review-of-literature
#7
Mehtap Evran, Murat Sert, Tamer Tetiker, Gamze Akkuş, Ömer Sunkar Biçer
Spontaneous calcaneal fractures in diabetic patients without obvious trauma may occur, sometimes accompanying diabetic foot ulcers. In the current study we report four cases who were hospitalized for diabetic foot ulcer with concomitant calcaneal fractures. There were four diabetic patients (one type 1 and three type 2) who registered with diabetic foot ulcers with coexisting calcaneal fractures, all of which were classified as Type A according to Essex Lopresti Calcaneal Fracture Classification. Two of the patients with renal failure were in a routine dialysis program, as well as vascular compromise and osteomyelitis in all of the patients...
July 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27446962/prevalence-and-risk-factors-for-diabetic-lower-limb-amputation-a-clinic-based-case-control-study
#8
Beverly T Rodrigues, Venkat N Vangaveti, Usman H Malabu
Objective. The aim of the study was to evaluate the prevalence of and risk factors for lower limb amputation in a specialist foot clinic-based setting. Methods. A retrospective quantitative study was conducted, using clinical and biochemical profiles of diabetic foot patients attending the High Risk Foot Clinic at The Townsville Hospital, Australia, between January 1, 2011, and December 31, 2013. Results. The total study sample included 129 subjects, comprising 81 males and 48 females with M : F ratio of 1...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27326940/acute-vascular-complications-flap-necrosis-and-congestion-with-one-stage-and-two-stage-distally-based-sural-flap-for-wound-coverage-around-the-ankle
#9
N M Yusof, A S Fadzli, W S Azman, M A Azril
INTRODUCTION: The understanding of the skin's vascular anatomy has improved in the last decade. It has lead to technique modification such as the staged procedure in performing sural flaps and improvement in the flap survival rate. The aim of this study was to evaluate the acute vascular complications (flap necrosis or congestion) of 29 patients who underwent distal base sural flap for coverage of wound around the ankle. METHODS: Twenty-four males and five females with a mean age of 37...
April 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/27084691/s100a8-a9-is-an-important-host-defence-mediator-in-neuropathic-foot-ulcers-in-patients-with-type-2-diabetes-mellitus
#10
Hannah Trøstrup, Per Holstein, Lars Christophersen, Bo Jørgensen, Tonny Karlsmark, Niels Høiby, Claus Moser, Magnus S Ågren
Chronic wounds and in particular diabetic foot ulcers (DFUs) are a growing clinical challenge, but the underlying molecular pathophysiological mechanisms are unclear. Recently, we reported reduced levels of the immunomodulating and antimicrobial S100A8/A9 in non-healing venous leg ulcers (VLUs), while another study found increased S100A8/A9 in DFUs. To clarify these apparently contradictory findings, we compared S100A8/A9 as well as an inducer, lipopolysaccharide (LPS) and selected innate immune response mediators in wound fluids from non-healing DFUs and VLUs with healing wounds...
July 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27073000/a-prospective-randomised-controlled-multicentre-clinical-trial-examining-healing-rates-safety-and-cost-to-closure-of-an-acellular-reticular-allogenic-human-dermis-versus-standard-of-care-in-the-treatment-of-chronic-diabetic-foot-ulcers
#11
Charles M Zelen, Dennis P Orgill, Thomas Serena, Robert Galiano, Marissa J Carter, Lawrence A DiDomenico, Jennifer Keller, Jarrod Kaufman, William W Li
Acellular dermal matrices can successfully heal wounds. This study's goal was to compare clinical outcomes of a novel, open-structure human reticular acellular dermis matrix (HR-ADM) to facilitate wound closure in non-healing diabetic foot ulcers (DFUs) versus DFUs treated with standard of care (SOC). Following a 2-week screening period in which DFUs were treated with offloading and moist wound care, patients were randomised to either SOC alone or HR-ADM plus SOC applied weekly for up to 12 weeks. At 6 weeks, the primary outcome time, 65% of the HR-ADM-treated DFUs healed (13/20) compared with 5% (1/20) of DFUs that received SOC alone...
April 12, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27068845/composite-skin-grafting-with-human-acellular-dermal-matrix-scaffold-for-treatment-of-diabetic-foot-ulcers-a-randomized-controlled-trial
#12
Zhicheng Hu, Jiayuan Zhu, Xiaoling Cao, Chufen Chen, Shuting Li, Dong Guo, Jian Zhang, Peng Liu, Fen Shi, Bing Tang
BACKGROUND: Composite split-thickness skin grafting (STSG) with acellular dermal matrix (ADM) has been used successfully in burn injuries and trauma, but its use in treating diabetic foot ulcers (DFUs) has not been reported to date. This study investigated the efficacy and safety of composite STSG with ADM in the treatment of DFUs. STUDY DESIGN: Fifty-two patients with DFUs were randomized into experimental and control groups. Patients in the experimental group received composite STSG over ADM; the control group received STSG alone...
June 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27068343/human-acellular-dermal-wound-matrix-for-complex-diabetic-wounds
#13
P Rupert
OBJECTIVE: Diabetic ulcers are the most common foot injuries leading to lower-extremity amputation and the most common cause of non-traumatic lower extremity amputations in the industrialised world. Approximately 85% of all diabetes-related lower-extremity amputations are preceded by foot ulcers. When foot ulcers develop despite preventive measures, early and appropriate treatment should be initiated to help reduce the burden of diabetes-related amputations. Recent advances now offer these patients a regenerative process of restoring the wound with human integument by replacing damaged or missing tissue with similar tissue rather than scar formation...
April 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27054051/epidermal-grafting-for-chronic-complex-wounds-in-india-a-case-series
#14
T V Prakash, Dr Ajay Chaudhary, Shyam Purushothaman, Smitha K V, Varada Arvind K
UNLABELLED: BACKGROUND : In India, the high cost of medical treatments and limited resources can deter patients from receiving available care, leading to the development of chronic wounds. We evaluated the use of epidermal grafting in patients with complex, long-term chronic wounds. METHODS: Eighteen patients with complex wounds were treated with epidermal micrografts between September 2014 and March 2015 at a state-run, community health center in Mahe, Puducherry, India...
2016: Curēus
https://www.readbyqxmd.com/read/27031550/dermacell-human-acellular-dermal-matrix-allograft-a-case-report
#15
Windy E Cole
Diabetes often causes ulcers on the feet of diabetic patients. A 56-year-old, insulin-dependent, diabetic woman presented to the wound care center with a Wagner grade 3 ulcer of the right heel. She reported a 3-week history of ulceration with moderate drainage and odor and had a history of ulceration and osteomyelitis in the contralateral limb. Rigorous wound care, including hospitalization; surgical incision and drainage; intravenous antibiotic drug therapy; vacuum-assisted therapy; and a new room temperature, sterile, human acellular dermal matrix graft were used to heal the wound, save her limb, and restore her activities of daily living...
March 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27015337/combination-of-vascular-intervention-surgery-and-free-tissue-transfer-for-critical-diabetic-limb-salvage
#16
Chieh Chou, Pao-Jen Kuo, Yen-Chou Chen, Shu-Hung Huang, Chih-Hau Chang, Yi-Chia Wu, Su-Shin Lee, Cheng-Sheng Lai, Sin-Daw Lin, Kao-Ping Chang, Yur-Ren Kuo
BACKGROUND: Complex, nontraumatic diabetic foot ulcers with peripheral vascular compromise often lead to extensive lower-limb amputation. The aim of this study is to determine the outcome of combined vascular intervention and free tissue transfer for critical diabetic limb salvage. MATERIALS AND METHODS: A total of 26 consecutive diabetic patients with 28 legs with diabetic foot ulcers who underwent limb salvage with a combination of revascularization (bypass surgery or endovascular angioplasty) and free flap transfers were reviewed...
February 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/26947695/epidermal-skin-grafting-in-patients-with-complex-wounds-a-case-series
#17
A Bhatia
OBJECTIVE: Complex wounds are often difficult to close and sometimes require a split-thickness skin graft (STSG). However, epidermal skin grafts, which contain only an epidermal layer of skin, are a viable option for wound coverage in these challenging wounds. We report our experience using an automated epidermal harvesting tool to harvest epidermal skin grafts for the treatment of complex wounds. METHOD: Epidermal skin grafts were harvested from the patient's thigh, which was first washed with isopropyl alcohol...
March 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/26933467/healing-rates-in-a-multicenter-assessment-of-a-sterile-room-temperature-acellular-dermal-matrix-versus-conventional-care-wound-management-and-an-active-comparator-in-the-treatment-of-full-thickness-diabetic-foot-ulcers
#18
Jodi Walters, Shawn Cazzell, Hau Pham, Dean Vayser, Alexander Reyzelman
OBJECTIVE: The purpose of this 16-week, multicenter, randomized, controlled trial was to assess the healed ulcer rate of a human acellular dermal matrix, DermACELL, compared with conventional care and a second acellular dermal matrix, Graftjacket, in the treatment of full-thickness diabetic foot ulcers. METHODS: One hundred sixty-eight patients were randomized into DermACELL, conventional care, and Graftjacket treatment arms in a 2:2:1 ratio. Patients in the acellular dermal matrix groups received either 1 or 2 applications of the graft at the discretion of the investigator...
2016: Eplasty
https://www.readbyqxmd.com/read/26927956/collagen-implant-with-gentamicin-sulphate-as-an-option-to-treat-a-neuroischaemic-diabetic-foot-ulcer-case-report
#19
C E Costa Almeida
INTRODUCTION: The ischaemic diabetic foot is associated with a faster evolving atherosclerosis affecting preferentially the bellow knee arteries. This distal ischemia associated with a wide distribution of multiple stenosis and occlusions throughout lower limb arteries, makes revascularization very hard or even impossible. This represents a major factor responsible for non-healing diabetic foot ulcer. In these cases all efforts should be made to find treatment alternatives that can promote ulcer healing...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26866804/skin-grafting-and-tissue-replacement-for-treating-foot-ulcers-in-people-with-diabetes
#20
REVIEW
Trientje B Santema, Paul P C Poyck, Dirk T Ubbink
BACKGROUND: Foot ulceration is a major problem in people with diabetes and is the leading cause of hospitalisation and limb amputations. Skin grafts and tissue replacements can be used to reconstruct skin defects for people with diabetic foot ulcers in addition to providing them with standard care. Skin substitutes can consist of bioengineered or artificial skin, autografts (taken from the patient), allografts (taken from another person) or xenografts (taken from animals). OBJECTIVES: To determine the benefits and harms of skin grafting and tissue replacement for treating foot ulcers in people with diabetes...
2016: Cochrane Database of Systematic Reviews
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